female infertility

Summary

Summary: Diminished or absent ability of a female to achieve conception.

Top Publications

  1. ncbi Fertility preservation in female patients
    Murat Sonmezer
    Ankara University School of Medicine, Ankara, Turkey and The Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    Hum Reprod Update 10:251-66. 2004
  2. pmc Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility
    Cory R Nicholas
    Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA 94304, USA
    Hum Mol Genet 18:4376-89. 2009
  3. ncbi Oxidative stress and its implications in female infertility - a clinician's perspective
    Ashok Agarwal
    Centre for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Department of Obstetrics Gynecology and Glickman Urological Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Reprod Biomed Online 11:641-50. 2005
  4. pmc Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function
    David Barad
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    J Assist Reprod Genet 24:629-34. 2007
  5. ncbi 'Men leave me as I cannot have children': women's experiences with involuntary childlessness
    S J Dyer
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa
    Hum Reprod 17:1663-8. 2002
  6. ncbi Female infertility in mice lacking connexin 37
    A M Simon
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 385:525-9. 1997
  7. ncbi Chlamydia trachomatis infection & female infertility
    Abida Malik
    Department of Microbiology, Aligarh Muslim University, Aligarh, India
    Indian J Med Res 123:770-5. 2006
  8. ncbi The effect of cancer treatment on female fertility and strategies for preserving fertility
    Theodoros Maltaris
    Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany
    Eur J Obstet Gynecol Reprod Biol 130:148-55. 2007
  9. ncbi Female subfertility
    Johannes L H Evers
    Department of Obstetrics and Gynaecology, Research Institute GROW, Academisch Ziekenhuis Maastricht, and Maastricht University, Maastricht, Netherlands
    Lancet 360:151-9. 2002
  10. ncbi Association between fertility drugs and gynecologic cancers, breast cancer, and childhood cancers
    Ali Ayhan
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Hacettepe, Ankara, Turkey
    Acta Obstet Gynecol Scand 83:1104-11. 2004

Detail Information

Publications261 found, 100 shown here

  1. ncbi Fertility preservation in female patients
    Murat Sonmezer
    Ankara University School of Medicine, Ankara, Turkey and The Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    Hum Reprod Update 10:251-66. 2004
    ..All current, emerging, experimental as well as controversial approaches are reviewed. A comprehensive algorithm to manage fertility preservation through an individualized approach is presented...
  2. pmc Transplantation directs oocyte maturation from embryonic stem cells and provides a therapeutic strategy for female infertility
    Cory R Nicholas
    Department of Obstetrics and Gynecology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Palo Alto, CA 94304, USA
    Hum Mol Genet 18:4376-89. 2009
    ..Embryonic stem cells (ESCs) provide an in vitro system to study oocyte development and potentially treat female infertility. However, most studies of ESC differentiation to oocytes have not documented fundamental properties of ..
  3. ncbi Oxidative stress and its implications in female infertility - a clinician's perspective
    Ashok Agarwal
    Centre for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Department of Obstetrics Gynecology and Glickman Urological Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Reprod Biomed Online 11:641-50. 2005
    ..This review discusses the sources of ROS in media used in IVF-embryo transfer and strategies to overcome OS in oocyte in-vitro maturation, in-vitro culture and sperm preparation techniques...
  4. pmc Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function
    David Barad
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    J Assist Reprod Genet 24:629-34. 2007
    ..We assessed the role of DHEA supplementation on pregnancy rates in women with diminished ovarian function...
  5. ncbi 'Men leave me as I cannot have children': women's experiences with involuntary childlessness
    S J Dyer
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, Observatory, 7925, South Africa
    Hum Reprod 17:1663-8. 2002
    ..This study explores the concerns and experiences related to involuntary childlessness of infertile women living in a diverse cultural urban community in South Africa...
  6. ncbi Female infertility in mice lacking connexin 37
    A M Simon
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 385:525-9. 1997
    ..Thus, cell-cell signalling through intercellular channels critically regulates the highly coordinated set of cellular interactions required for successful oogenesis and ovulation...
  7. ncbi Chlamydia trachomatis infection & female infertility
    Abida Malik
    Department of Microbiology, Aligarh Muslim University, Aligarh, India
    Indian J Med Res 123:770-5. 2006
    ..trachomatis is increasingly being associated with long-term complications like infertility. The present study was undertaken to assess the role of C. trachomatis in female infertility as such data are lacking.
  8. ncbi The effect of cancer treatment on female fertility and strategies for preserving fertility
    Theodoros Maltaris
    Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany
    Eur J Obstet Gynecol Reprod Biol 130:148-55. 2007
    ....
  9. ncbi Female subfertility
    Johannes L H Evers
    Department of Obstetrics and Gynaecology, Research Institute GROW, Academisch Ziekenhuis Maastricht, and Maastricht University, Maastricht, Netherlands
    Lancet 360:151-9. 2002
    ..has sufficient exposure to the chance of conception taken place? Are cost-effective, safe, and reliable treatments available for the disorder diagnosed? And, should the couple be referred straightaway for assisted reproduction?..
  10. ncbi Association between fertility drugs and gynecologic cancers, breast cancer, and childhood cancers
    Ali Ayhan
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Hacettepe, Ankara, Turkey
    Acta Obstet Gynecol Scand 83:1104-11. 2004
    ..Although it is still early to state the last words on this topic, the possible association should be addressed when obtaining an informed consent before starting treatment...
  11. ncbi Aromatase inhibitors for female infertility: a systematic review of the literature
    Nikolaos P Polyzos
    PACMeR Panhellenic Association for Continual Medical Research, Section of Obstetrics and Gynaecology and Public Health, Athens 10438, Greece
    Reprod Biomed Online 19:456-71. 2009
    ..A systematic review of the literature was conducted in order to highlight the efficacy and safety of AI in female infertility. Current data from randomized and non-randomized trials suggest that AI may have a role in ovulation ..
  12. ncbi Psychological impact of infertility
    Tara M Cousineau
    Domar Center for Complementary Healthcare, Boston IVF, Beth Israel Deaconess Medical Center, Harvard Medical School, 130 Second Avenue, Waltham, Massachusetts 02451, USA
    Best Pract Res Clin Obstet Gynaecol 21:293-308. 2007
    ..Further research is needed to understand the association between distress and fertility outcome, as well as effective psychosocial interventions...
  13. ncbi The economic impact of assisted reproductive technology: a review of selected developed countries
    Georgina M Chambers
    Perinatal and Reproductive Epidemiology Research Unit, School of Women s and Children s Health, University of New South Wales, Randwick, New South Wales, Australia
    Fertil Steril 91:2281-94. 2009
    ..To compare regulatory and economic aspects of assisted reproductive technologies (ART) in developed countries...
  14. ncbi Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF?
    Simon Fishel
    CARE Fertility, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom
    Fertil Steril 93:1006.e7-1006.e10. 2010
    ....
  15. ncbi The variability of female reproductive ageing
    Egbert R te Velde
    Department of Reproductive Medicine, University Medical Centre, Utrecht, The Netherlands
    Hum Reprod Update 8:141-54. 2002
    ..Some of those genes must carry heritable variants which modulate the rate of ovarian ageing and give rise to the wide age variations for the various phases of reproductive ageing...
  16. ncbi Chlamydia trachomatis infection in women with secondary infertility
    Abida Malik
    Department of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
    Fertil Steril 91:91-5. 2009
    ..To assess the role of Chlamydia in secondary infertility in a prospective study...
  17. ncbi Defect in SHAP-hyaluronan complex causes severe female infertility. A study by inactivation of the bikunin gene in mice
    L Zhuo
    Institute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi, 480 1195, Japan
    J Biol Chem 276:7693-6. 2001
    ..The ovulated oocytes were completely devoid of matrix and were unfertilized, leading to severe female infertility. Intraperitoneal administration of ITI, accompanied by the formation of the SHAP-HA complex, fully rescued ..
  18. ncbi Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate
    Togas Tulandi
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Fertil Steril 85:1761-5. 2006
    ..To evaluate the incidence of congenital malformations among offspring of mothers who conceived with clomiphene citrate (CC) or with letrozole treatment for infertility...
  19. ncbi Aberrant integrin expression in the endometrium of women with endometriosis
    B A Lessey
    Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599
    J Clin Endocrinol Metab 79:643-9. 1994
    ..In conclusion, aberrant integrin expression in the native endometrium is associated with the finding of endometriosis and may identify some women with decreased cycle fecundity due to defects in uterine receptivity...
  20. ncbi Psychiatric morbidity amongst infertile Chinese women undergoing treatment with assisted reproductive technology and the impact of treatment failure
    Iingrid Hung Lok
    Department of Obstetrics and Gynecology, Prince of Wales Hospital, Chinese University of Hong Kong, People s Republic of China
    Gynecol Obstet Invest 53:195-9. 2002
    ..Proper psychological care and counseling should be an integral part of infertility management among the Chinese population...
  21. pmc Conditional deletion of beta-catenin mediated by Amhr2cre in mice causes female infertility
    Jennifer A Hernandez Gifford
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4660, USA
    Biol Reprod 80:1282-92. 2009
    ..Collectively, these data suggest that FSH regulation of steroidogenesis requires beta-catenin, a role that remains hidden when tested through Amhr2cre-mediated recombination in vivo...
  22. ncbi Effects of ascorbic acid supplementation on serum progesterone levels in patients with a luteal phase defect
    Hirofumi Henmi
    Fertil Steril 80:459-61. 2003
  23. ncbi Ovulation induction management of PCOS
    David S Guzick
    University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Clin Obstet Gynecol 50:255-67. 2007
    ..If there is no pregnancy despite several cycles of successful ovulation induction, gonadotropin treatment should be considered, in which case in vitro fertilization is recommended as the safest and most effective strategy...
  24. ncbi Variations in folate pathway genes are associated with unexplained female infertility
    Signe Altmäe
    Department of Clinical Science, Division of Obstetrics and Gynecology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Fertil Steril 94:130-7. 2010
    To investigate associations between folate-metabolizing gene variations, folate status, and unexplained female infertility.
  25. ncbi Differential growth of human embryos in vitro: role of reactive oxygen species
    Mohamed A Bedaiwy
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Fertil Steril 82:593-600. 2004
    ..To examine the relationship of early human embryonic development with the level of reactive oxygen species (ROS) in the culture media on the first day (day 1 ROS) after insemination...
  26. ncbi Aromatase inhibition reduces gonadotrophin dose required for controlled ovarian stimulation in women with unexplained infertility
    M F M Mitwally
    Samuel Lunenfeld Research Institute and Mount Sinai Hospital, Reproductive Sciences Division, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada
    Hum Reprod 18:1588-97. 2003
    ..Previously, we reported the success of aromatase inhibition in inducing ovulation without antiestrogenic effects...
  27. ncbi Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization-embryo transfer who repeatedly cannot conceive
    Flavio G Oliveira
    Clinica e Centro de Pesquisa em Reproducao Humana Roger Abdelmassih, Sao Paulo, SP, Brazil
    Fertil Steril 80:1371-5. 2003
    ..To assess hysteroscopic findings in patients undergoing IVF-ET who repeatedly failed to conceive despite transfer of good-quality embryos...
  28. ncbi Efficiency of oocyte cryopreservation: a meta-analysis
    Kutluk Oktay
    Fertility Preservation Program at Center for Reproductive Medicine and Infertility, New York, New York, USA
    Fertil Steril 86:70-80. 2006
    ..To determine the efficiency of oocyte cryopreservation relative to IVF with unfrozen oocytes...
  29. ncbi What are the implications of myomas on fertility? A need for a debate?
    J Donnez
    Department of Gynecology, Catholic University of Louvain, Cliniques Universitaires St Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium
    Hum Reprod 17:1424-30. 2002
    ..The absence of an answer to this crucial question is probably due to the fact that we have not yet conducted the appropriate prospective studies required to obtain any clear results...
  30. ncbi Prevalence of female infertility and its socio-economic factors in tribal communities of Central India
    Dinesh Kumar
    Banaras Hindu University, Regional Medical Research Centre for Tribals ICMR, Jabalpur M P, India
    Rural Remote Health 7:456. 2007
    ..The objective of the study was to determine for the first time the prevalence of infertility in these two tribal groups...
  31. ncbi Ovarian cancer risk associated with varying causes of infertility
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20852, USA
    Fertil Steril 82:405-14. 2004
    ..To evaluate the risk of ovarian cancer as related to underlying causes of infertility...
  32. ncbi Levothyroxine treatment in thyroid peroxidase antibody-positive women undergoing assisted reproduction technologies: a prospective study
    Roberto Negro
    Department of Internal Medicine, Division of Physiopathology of Human Reproduction, Casa di Cura Salus, Brindisi
    Hum Reprod 20:1529-33. 2005
    ..Our objective was to investigate if levothyroxine (LT4) exerts any effect on pregnancy and/or delivery rates in thyroid peroxidase antibody (TPOAb)-positive (+) women undergoing assisted reproductive technologies...
  33. ncbi Increased nitric oxide in peritoneal fluid from women with idiopathic infertility and endometriosis
    M Dong
    Women s Hospital, School of Medicine, Zhejiang University, 2 Xueshi Road, Hangzhou, Zhejiang 310006, P R C
    J Reprod Med 46:887-91. 2001
    ..To verify whether nitric oxide in peritoneal fluid is associated with endometriosis and infertility...
  34. pmc Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility
    Silvia Masciarelli
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 114:196-205. 2004
    ..Pde3a(-/-) mice represent an in vivo model where meiotic maturation and ovulation are dissociated, which underscores inhibition of oocyte maturation as a potential strategy for contraception...
  35. ncbi A randomized trial of letrozole versus clomiphene citrate in women undergoing superovulation
    Haya Al-Fozan
    Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
    Fertil Steril 82:1561-3. 2004
    ..To compare the effects of the aromatase inhibitor letrozole (7.5 mg) and clomiphene citrate (CC; 100 mg) in women undergoing superovulation and IUI...
  36. ncbi Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors
    Hisako Muramatsu
    Department of Biochemistry, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Genes Cells 11:1405-17. 2006
    ..These abnormalities in combination resulted in female infertility. Therefore, midkine and pleiotrophin, together with their signaling receptors, play important roles in the ..
  37. ncbi Fertility in female cancer survivors: pathophysiology, preservation and the role of ovarian reserve testing
    Kerryn Lutchman Singh
    Department of Obstetrics and Gynaecology, Reproductive Medicine Unit, Elizabeth Garrett Anderson and Obstetric Hospital, University College London Hospital, Huntley Street, London WC1E 6DH, UK
    Hum Reprod Update 11:69-89. 2005
    ..Large, prospective, randomized, adequately controlled studies specific to different geographical areas are required in a control population of comparable reproductive age to determine the potential role of ORT in clinical practice...
  38. ncbi Role of reactive oxygen species in the pathophysiology of human reproduction
    Ashok Agarwal
    Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Urological Institute and Department of Obstetrics Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Fertil Steril 79:829-43. 2003
    ..To summarize the role of reactive oxygen species (ROS) in the pathophysiology of human reproduction...
  39. ncbi Livebirth after orthotopic transplantation of cryopreserved ovarian tissue
    J Donnez
    Department of Gynaecology, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Avenue Hippocrate 10, B 1200, Brussels, Belgium
    Lancet 364:1405-10. 2004
    ..In 1997, biopsy samples of ovarian cortex were taken from a woman with stage IV Hodgkin's lymphoma and cryopreserved before chemotherapy was initiated. After her cancer treatment, the patient had premature ovarian failure...
  40. ncbi Mood disorders and fertility in women: a critical review of the literature and implications for future research
    Katherine E Williams
    Stanford Center for Neuroscience in Women s Health, Department of Psychiatry and Behavioural Sciences, Stanford University and Hospitals, Stanford, CA 94305, USA
    Hum Reprod Update 13:607-16. 2007
    ....
  41. ncbi Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
    S Teglund
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell 93:841-50. 1998
    ..Conversely, the responses to a variety of cytokines that activate the Stat5 proteins, including erythropoietin, are largely unaffected...
  42. ncbi HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: a case-control study
    A H Kinnunen
    National Public Health Institute, 90101 Oulu, Finland
    Hum Reprod 17:2073-8. 2002
    ..The relationship between Chlamydia trachomatis tubal factor infertility (TFI) and the host's immunoregulatory genes was studied...
  43. ncbi Mutations affecting cell division in Drosophila
    M Gatti
    Dipartimento di Genetica e Biologia Molecolare, Universita di Roma, La Sapienza, Italy
    Methods Cell Biol 35:543-86. 1991
  44. ncbi Physical activity, body mass index, and ovulatory disorder infertility
    Janet W Rich-Edwards
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02115, USA
    Epidemiology 13:184-90. 2002
    ..These data suggest that, among American women, more ovulatory infertility is attributable to overweight and a sedentary lifestyle than to underweight and overexertion...
  45. ncbi Ovulation induction with urinary FSH or recombinant FSH in polycystic ovary syndrome patients: a prospective randomized analysis of cost-effectiveness
    Sandro Gerli
    Centre of Reproductive and Perinatal Medicine, Department of Gynecological, Obstetrical and Pediatric Sciences, University of Perugia, Italy
    Reprod Biomed Online 9:494-9. 2004
    ..37 in the rFSH group. In conclusion, uFSH and rFSH demonstrated the same effectiveness in ovarian stimulation in IUI cycles in PCOS patients. The urinary preparation is more cost-effective due to the difference of its cost per IU...
  46. ncbi The impact of lifestyle risk factors on female infertility
    Susan Kelly-Weeder
    Boston College, William F Connell School of Nursing, Cushing Hall 420, 140 Commonwealth Ave, Chestnut Hill, MA 02467, and St Jude Faculty, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Women Health 44:1-23. 2006
    ..With knowledge of the importance of behavioral threats to fertility, women's health care providers will be in a better position to screen and assist women to modify their fertility risks...
  47. ncbi Cytomegalovirus (CMV) infection--related to male and/or female infertility factors?
    Waltraud Eggert-Kruse
    Department of Gynecological Endocrinology and Reproductive Medicine, Women s Hospital, University of Heidelberg, Heidelberg, Germany
    Fertil Steril 91:67-82. 2009
    ..To screen for cytomegalovirus (CMV) infection in male and female partners of subfertile couples and to analyze a potential relationship with clinically relevant parameters of male and female factor fertility...
  48. ncbi Putative predictors of antibodies against follicle-stimulating hormone in female infertility: a study based on in vitro fertilization patients
    Kadri Haller
    Department of Immunology, Institute of General and Molecular Pathology, Centre of Molecular and Clinical Medicine, University of Tartu, Biomedicum, Ravila Str 19, Tartu 50411, Estonia
    Am J Reprod Immunol 57:193-200. 2007
    ..Here, we investigated the parameters associated with anti-FSH antibodies in in vitro fertilization (IVF) patients...
  49. ncbi Roadmap to embryo implantation: clues from mouse models
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Rev Genet 7:185-99. 2006
    ..A better understanding of periimplantation biology could alleviate female infertility and help to develop novel contraceptives.
  50. pmc Hurp deficiency in mice leads to female infertility caused by an implantation defect
    Ching Yen Tsai
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, Taipei 112, Taiwan
    J Biol Chem 283:26302-6. 2008
    ..Our results demonstrate for the first time that HURP affects endometrial stromal proliferation during implantation but is dispensable during normal development in mice; specifically, HURP has an essential function in uterine biology...
  51. ncbi Ovarian reserve
    Maria Elisabetta Coccia
    Department of Gynaecology, Perinatology and Human Reproduction, University of Florence, 50100 Florence, Italy
    Ann N Y Acad Sci 1127:27-30. 2008
    ..But the simultaneous evaluation of a combination of tests could be used as a marker of diminished ovarian reserve and a sensitive predictor of response to ovarian stimulation in patients undergoing in vitro fertilization treatment...
  52. ncbi Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility
    L C Kao
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Stanford University, Stanford, CA 94305 5317, USA
    Endocrinology 144:2870-81. 2003
    ....
  53. ncbi Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF
    J Y H Kwak-Kim
    Reproductive Medicine, Department of Obstetrics and Gynecology, Finch University of Health Sciences The Chicago Medical School, 3333 Green Bay Road, N Chicago, IL 60064, USA
    Hum Reprod 18:767-73. 2003
    ..We aimed to study T-helper 1 (Th1) and Th2 intracellular cytokine expression in peripheral blood lymphocytes of women with recurrent spontaneous abortions (RSA) or infertility with multiple implantation failures after IVF cycles...
  54. pmc Mice lacking the nuclear pore complex protein ALADIN show female infertility but fail to develop a phenotype resembling human triple A syndrome
    Angela Huebner
    Children s Hospital, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Mol Cell Biol 26:1879-87. 2006
    ..Thus, in mice either the function of ALADIN differs from that in humans, its loss can be readily compensated for, or additional factors, such as environmental conditions or genetic modifiers, contribute to the disease...
  55. ncbi Fertility preservation options for female patients with malignancies
    Emre Seli
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Curr Opin Obstet Gynecol 17:299-308. 2005
    ..This review summarizes available options and discusses recently published data concerning experimental methods. Specific strategies for fertility preservation in women with gynecologic malignancies are also presented...
  56. ncbi Ascorbic acid and infertility treatment
    I Crha
    Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University, Obilni trh 11, 602 00 Brno, Czech Republic
    Cent Eur J Public Health 11:63-7. 2003
    ..To assess the ascorbic acid (AA) in the follicular fluid in women treated by in vitro fertilization and embryonic transfer levels (IVF/ET) and to analyse the influence of vitamin C supplementation on the results of infertility treatment...
  57. ncbi Hysteroscopic resection of the septum improves the pregnancy rate of women with unexplained infertility: a prospective controlled trial
    Antonio Mollo
    Department of Obstetrics, Gynecology, Urology, and Reproductive Medicine, Federico II University of Naples, Italy
    Fertil Steril 91:2628-31. 2009
    ..To assess fecundity of infertile women after surgical correction of uterine septum...
  58. ncbi Domestic violence against infertile women in a Turkish setting
    Recep Yildizhan
    Department of Obstetrics and Gynecology, Training and Research Hospital, School of Medicine, Yuzuncu Yil University, Van, Turkey
    Int J Gynaecol Obstet 104:110-2. 2009
    ..To investigate the prevalence of domestic violence against infertile women in a Turkish setting...
  59. pmc Replete vitamin D stores predict reproductive success following in vitro fertilization
    Sebiha Ozkan
    Kocaeli University, School of Medicine, Department of Obstetrics and Gynecology, Kocaeli, Turkey
    Fertil Steril 94:1314-9. 2010
    ....
  60. ncbi Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART)
    A La Marca
    Mother Infant Department, University of Modena and Reggio Emilia, Policlinico of Modena, Modena, Italy
    Hum Reprod Update 16:113-30. 2010
    ..In men AMH is secreted in both the serum and seminal fluid. Its measurement may be useful in clinical evaluation of the infertile male...
  61. ncbi Economic consequences of overweight and obesity in infertility: a framework for evaluating the costs and outcomes of fertility care
    A M H Koning
    Department of Obstetrics and Gynaecology, Meander Medical Centre, Ringweg Randenbroek 110, Amersfoort, The Netherlands
    Hum Reprod Update 16:246-54. 2010
    ..We studied the consequences of overweight and obesity with respect to fecundity, costs of fertility treatment and pregnancy outcome in subfertile women...
  62. ncbi Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility
    Barbara H Osborn
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27705, USA
    Fertil Steril 77:46-51. 2002
    ..Determine whether peritoneal macrophages from women with endometriosis-associated infertility express more inducible nitric oxide synthase (NOS2) and produce more NO than fertile controls...
  63. ncbi Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome
    John E Nestler
    Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0111, USA
    Fertil Steril 77:209-15. 2002
    ....
  64. ncbi Fluid accumulation within the uterine cavity reduces pregnancy rates in women undergoing IVF
    Li Wei Chien
    Department of Obstetrics and Gynaecology, Taipei Medical University Hospital, Taipei, Taiwan
    Hum Reprod 17:351-6. 2002
    ..The occurrence of fluid accumulation within the uterine cavity was examined in women undergoing IVF to investigate its correlation with tubal disease and impact on the pregnancy outcome...
  65. ncbi Fertility and adjuvant treatment in young women with breast cancer
    Ann H Partridge
    Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, D1210 Boston, MA 02115, USA
    Breast 16:S175-81. 2007
    ..Ongoing and future prospective studies evaluating fertility and pregnancy issues for young breast cancer survivors are warranted for this vulnerable population facing this difficult issue...
  66. ncbi The direct medical cost of cardiovascular diseases, hypertension, diabetes, cancer, pregnancy and female infertility in a large HMO in Israel
    Gabriel Chodick
    Medical Division, Maccabi Healthcare Services, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Health Policy 95:271-6. 2010
    ..The aim of this study was to assess the direct medical cost of treating major chronic illnesses in Maccabi Healthcare Services, a 1.8 million member health maintenance organization in Israel...
  67. ncbi Declining estimates of infertility in the United States: 1982-2002
    Elizabeth Hervey Stephen
    School of Foreign Service, Georgetown University, Washington, DC 20057, USA
    Fertil Steril 86:516-23. 2006
    ..To determine if the decline in infertility has been uniform across subgroups...
  68. ncbi Reproduction beyond cancer: a message of hope for young women
    Theodoros Maltaris
    Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz University Hospital, Langenbeckstrasse 1, 55124 Mainz, Germany
    Gynecol Oncol 103:1109-21. 2006
    ..The objective of this review is to discuss the effect of the various cancer treatments on fertility and present the various fertility sparing operations and fertility preservation strategies...
  69. ncbi Leukaemia inhibitory factor and interleukin 11 levels in uterine flushings of infertile patients with endometriosis
    M Mikolajczyk
    Department of Obstetrics and Gynecology, Division of Reproduction, University of Medical Sciences, Poznan, Poland
    Hum Reprod 21:3054-8. 2006
    ..We decided to test whether there is an altered secretion of these factors, which could explain receptivity defect in patients with minimal endometriosis...
  70. ncbi Cetrorelix in the treatment of female infertility and endometriosis
    Dominique Finas
    Department of Andrology and the Out Patient Clinic, Department of Obstetrics and Gynaecology, University Clinic of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Expert Opin Pharmacother 7:2155-68. 2006
    ..In the future, new nonpeptic GnRH antagonists are expected to be available for oral administration. Although they are still under investigation, these agents have the potential to improve patients' comfort and compliance...
  71. ncbi Abnormally up-regulated cystic fibrosis transmembrane conductance regulator expression and uterine fluid accumulation contribute to Chlamydia trachomatis-induced female infertility
    Qiong He
    Epithelial Cell Biology Research Center, Key Laboratory for Regenerative Medicine of Ministry of Education of China, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People s Republic of China
    Fertil Steril 93:2608-14. 2010
    ..trachomatis-induced female infertility.
  72. ncbi High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis
    N Sinaii
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, NIH, 10 Center Drive, Building 10, Room 9D42, MSC 1583, Bethesda, MD 20892 1583, USA
    Hum Reprod 17:2715-24. 2002
    ..This study examined whether the prevalence of autoimmune, chronic pain and fatigue and atopic disorders is higher in women with endometriosis than in the general female population...
  73. ncbi Aromatase gene (CYP19A1) variants, female infertility and ovarian stimulation outcome: a preliminary report
    Signe Altmäe
    Department of Biotechnology, Institute of Molecular and Cell Biology, Estonian Genome Foundation, University of Tartu, Estonia
    Reprod Biomed Online 18:651-7. 2009
    ..and (TTTA)(n) microsatellite intronic polymorphisms on ovarian stimulation outcome and aetiology of female infertility. IVF patients (n = 152) underwent ovarian stimulation according to recombinant FSH and gonadotrophin ..
  74. ncbi Difference in physiogenomics between male and female infertility
    V Wiwanitkit
    Wiwanitkit House, Bangkhae, Bangkok, Thailand Hainan Medical College, Hainan, China
    Andrologia 40:158-60. 2008
    ..Although it has been determined for a long time, there is no clear cut genetic difference between male and female infertility. Systemic approach on the pathophysiology and genomics might provide useful information to better understand ..
  75. ncbi Indices of oxidative stress in eutopic and ectopic endometria of women with endometriosis
    Yıldız Oner-Iyidogan
    Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Gynecol Obstet Invest 57:214-7. 2004
    ..It is suggested that various factors, such as cytokines released by activated macrophages in the peritoneal fluid and 17beta-estradiol itself synthesized by the ovaries, may locally affect the oxidant status of ectopic endometria...
  76. ncbi A nutritional supplement for improving fertility in women: a pilot study
    Lynn M Westphal
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Reprod Med 49:289-93. 2004
    ..To determine the impact of nutritional supplementation on optimization of reproductive health in women...
  77. ncbi Increased depression and anxiety in infertile Japanese women resulting from lack of husband's support and feelings of stress
    Hidehiko Matsubayashi
    Department of Obstetrics and Gynecology, Center for Specialized Clinical Science, Tokai University School of Medicine, Isehara, Kanagawa 259 1193, Japan
    Gen Hosp Psychiatry 26:398-404. 2004
    ..Psychological interventions to relieve or diminish these conditions might have significant therapeutic benefits for women attending infertility clinics in Japan...
  78. ncbi Peritoneal fluid environment in endometriosis. Clinicopathological implications
    M A Bedaiwy
    Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Minerva Ginecol 55:333-45. 2003
    ....
  79. ncbi An evidence-based evaluation of endometriosis-associated infertility
    Elizabeth A Pritts
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Wisconsin, H4 630 CSC, 600 Highland Avenue, Madison, WI 53792 6188, USA
    Endocrinol Metab Clin North Am 32:653-67. 2003
    ..As the data from these scientific inquiries emerge, clinicians will have a clearer view of effective treatment regimens for endometriosis...
  80. pmc Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation
    Femke A T de Vries
    Department of Toxicogenetics, Leiden University Medical Centre, The Netherlands
    Genes Dev 19:1376-89. 2005
    ..Crossovers were rare in metaphase I of Sycp1(-/-) mice. We propose that SYCP1 has a coordinating role, and ensures formation of crossovers. Unexpectedly, Sycp1(-/-) spermatocytes did not form XY bodies...
  81. ncbi Use of the internet as the only outlet for talking about infertility
    Yakov M Epstein
    Center for Mathematics, Science, and Computer Education, Piscataway, New Jersey 08855, USA
    Fertil Steril 78:507-14. 2002
    ....
  82. ncbi Time elapsed from onset of symptoms to diagnosis of endometriosis in a cohort study of Brazilian women
    M S Arruda
    Department of Obstetrics and Gynaecology, Universidade Estadual de Campinas, Campinas, Brazil
    Hum Reprod 18:756-9. 2003
    ..The study aim was to assess the time elapsed between onset of symptoms and diagnosis of endometriosis, and to identify the factors associated with diagnostic delay in a group of Brazilian women...
  83. ncbi Investigation of the infertile couple: when is the appropriate time to explore female infertility?
    Ivo Brosens
    Leuven Institute for Fertility and Embryology, Tiensevest 168, B 3000, Leuven, Belgium
    Hum Reprod 19:1689-92. 2004
    While the appropriate method for the investigation of female infertility continues to be debated, the timing of the investigation has received less attention...
  84. ncbi Female infertility and free radicals: potential role in adhesions and endometriosis
    Zeynep Alpay
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan 48201, USA
    J Soc Gynecol Investig 13:390-8. 2006
    ..As our knowledge of both conditions expands, we believe there will be opportunities for specific steps to intervention in free radical metabolism to reduce and/or prevent further development of endometriosis and adhesions...
  85. ncbi The endometrium as a cause of implantation failure
    Andrew M Sharkey
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Best Pract Res Clin Obstet Gynaecol 17:289-307. 2003
    ..The potential impact of these tools on clinical practice will be discussed...
  86. ncbi Genetic dissection of mammalian fertility pathways
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Nat Cell Biol 4:s41-9. 2002
    ....
  87. ncbi Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    P Sicinski
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Nature 384:470-4. 1996
    ..The hypoplasia seen in cyclin D2(-/-) ovaries and testes prompted us to examine human cancers deriving from corresponding tissues. We find that some human ovarian and testicular tumours contain high levels of cyclin D2 messenger RNA...
  88. ncbi Female infertility--effect of perinatal xenoestrogen exposure on reproductive functions in animals and humans
    F Gotz
    Institute of Experimental Endocrinology, Humboldt University Medical School Charité, Berlin, Germany
    Folia Histochem Cytobiol 39:40-3. 2001
    ..Epidemiological and experimental data speak in favour of environmental estrogens to be one cause for the development of polycystic ovaries, being the most important reason for female infertility in the human.
  89. ncbi Concurrent ganirelix and follitropin beta therapy is an effective and safe regimen for ovulation induction in women with polycystic ovary syndrome
    Karen E Elkind-Hirsch
    Woman s Health Research Institute, Woman s Hospital, Baton Rouge, Louisiana 70810, USA
    Fertil Steril 79:603-7. 2003
    ..To evaluate controlled ovarian stimulation cycles using the GnRH antagonist ganirelix in combination with the recombinant FSH, follitropin-beta, in women with polycystic ovary syndrome (PCOS)...
  90. ncbi Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary
    Jacob Tangir
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Obstet Gynecol 101:251-7. 2003
    ..To analyze the long-term effects on reproductive function of fertility-preserving treatment for malignant germ cell tumors of the ovary...
  91. ncbi Stress of female infertility: relations to length of treatment
    H Chiba
    Department of Nursing, Yamagata University School of Medicine, Japan
    Gynecol Obstet Invest 43:171-7. 1997
    ..According to STAI, CES-D and CMI, infertile women are considered to become more depressive the longer treatment persists. Therefore, counseling for infertile women should be adapted to long-term treatment...
  92. pmc 1000 office-based hysteroscopies prior to in vitro fertilization: feasibility and findings
    Mary D Hinckley
    Stanford University School of Medicine, Stanford, California 94305, USA
    JSLS 8:103-7. 2004
    ..This study reviews the findings and feasibility of office-based diagnostic and operative hysteroscopy in an unselected in vitro fertilization (IVF) population to evaluate whether first-line hysteroscopy should be recommended...
  93. pmc Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse
    Heather L Franco
    Department of Molecular and Cellular Biology, Department of Molecular and Human Genetics, The Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Biol Reprod 82:991-9. 2010
    ..Thus, constitutive activation of Smo in the mouse uterus alters postnatal uterine differentiation which interferes with early pregnancy. These results provide new insight into the role of Hedgehog signaling during embryo implantation...
  94. ncbi Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility
    Atsutaka Kubosaki
    Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 147:811-5. 2006
    b>Female infertility is a worldwide problem affecting 10-15% of the population. The cause of the infertility in many cases is not known...
  95. ncbi Screening for uterine abnormalities by three-dimensional ultrasound improves perinatal outcome
    Sanja Kupesic
    Department of Obstetrics and Gynecology, Medical School University of Zagreb, Sveti Duh Hospital, Zagreb, Croatia
    J Perinat Med 30:9-17. 2002
    ..We found significant improvement in reproductive outcome after operative hysteroscopy in secondary infertile patients with septate uterus and/or other uterine abnormalities...
  96. ncbi Risk of cancer after use of fertility drugs with in-vitro fertilisation
    A Venn
    Centre for the Study of Mothers and Children s Health, La Trobe University, Carlton, Victoria, Australia
    Lancet 354:1586-90. 1999
    ....
  97. ncbi A comparative randomized multicentric study comparing the step-up versus step-down protocol in polycystic ovary syndrome
    S Christin-Maitre
    Reproductive Endocrine Unit, EA 1533, Hopital Saint Antoine, 75012 Paris, France
    Hum Reprod 18:1626-31. 2003
    ..The aim of the study was to evaluate follicular development and ovulation comparing the low-dose step-up and the step-down protocols, in women with clomiphene citrate (CC)-resistant polycystic ovaries...
  98. pmc Antibodies to the chlamydial 60 kilodalton heat shock protein in women with tubal factor infertility
    K A Ault
    Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, USA
    Infect Dis Obstet Gynecol 6:163-7. 1998
    ..Our objective was to study the relationship between antibody response to 60 kilodalton chlamydial hsp and tubal factor infertility (TFI)...
  99. ncbi Total antioxidant status of peritoneal fluid in infertile women
    G Polak
    Department of Medical Microbiology, University School of Medicine, ul Lubartowska 85, 20 123 Lublin, Poland
    Eur J Obstet Gynecol Reprod Biol 94:261-3. 2001
    ..To determine whether impairment of the antioxidant systems of peritoneal fluid might be a factor responsible for infertility...
  100. ncbi Fertility preservation in young women undergoing breast cancer therapy
    Murat Sonmezer
    Fertility Preservation Program, Center for Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, Joan and Sanford I Weill Medical College of Cornell University, New York, New York, USA
    Oncologist 11:422-34. 2006
    ..The benefit of ovarian protection by gonadotropin-releasing hormone analogues is unproven and unlikely, and thus this treatment should not be offered as the sole method of fertility preservation...
  101. ncbi Morphometric analysis of peri-implantation endometrium in patients having excessively high oestradiol concentrations after ovarian stimulation
    G S Basir
    Department of Obstetrics and Gynaecology, 6/ F Professorial Block, Queen Mary Hospital, PokfulamRoad, Hong Kong
    Hum Reprod 16:435-40. 2001
    ..This substantiates our previous clinical observation of significantly lower pregnancy rates in IVF cycles of women with high oestradiol concentrations (> or =20,000 pmol/l)...

Research Grants62

  1. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    ..methoxychlor, during in utero or early postnatal developmental periods, may cause ovarian dysfunction and female infertility in adulthood via epigenetic mechanisms (e.g., DNA methylation)...
  2. Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone
    AARON JW HSUEH; Fiscal Year: 2013
    ..Although FSH has been used extensively for the treatment of female infertility, a sub-population of patients showed low FSH responses and has no alternative therapeutic options...
  3. Receptor/Ligand Signals for Ovarian Follicular Angiogenesis
    Leon J Spicer; Fiscal Year: 2010
    ..to newly discovered markers for cystic follicles and may also lead to new options for improved treatment of female infertility and ovarian pathologies such as polycystic ovarian disease and ovarian cancer...
  4. Effects of Lactational Exposure to Chromium (VI) on Ovarian Development
    SAKHILA BANU; Fiscal Year: 2010
    ..b>Female infertility has increased in industrialized countries...
  5. DEVELOPMENT OF MAMMALIAN OOCYTE-GRANULOSA CELL COMPLEX
    John J Eppig; Fiscal Year: 2012
    ..Although the etiologies causing female infertility are diverse, poor development of oocytes and follicles, ovulatory failure, and premature menopause are ..
  6. Ovarian-specific transcription networks regulated by the TFIID subunit TAF4b
    RICHARD NEIL FREIMAN; Fiscal Year: 2013
    ..of TAF4b-deficient mouse ovaries revealed several reproductive deficits that collectively result in female infertility. By assessing estrous cyclicity, ovarian pathology and gene expression changes in young TAF4b-deficient ..
  7. INTRAFLAGELLAR TRANSPORT IN CHLAMYDOMONAS REINHARDTII
    DOUGLAS COLE; Fiscal Year: 2009
    ..of human diseases including retinal degeneration, immotilie cilia and Kartagener's syndromes, male and female infertility, hydrocephalus and anosmia, Bardet- Beidl syndrome and one of the most commongenetic diseases in man, ..
  8. Follicular and endometrial pathology in polycystic ovary syndrome
    ANNE ELIZABETH NEWELL-FUGATE; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is the most common cause of female infertility and results in a substantial financial burden to the American healthcare system...
  9. Determining the role of RFRP-3 in stress-related female infertility
    MOLLY JOANNE DICKENS; Fiscal Year: 2013
    ..Ultimately, the goal of this research is to help define a mode of dysregulation underlying stress-induced infertility in women. ..
  10. The Aging Pituitary-Gonadal Axis
    George R Bousfield; Fiscal Year: 2013
    ..This line will be crossed with FSH null mice to see if it can rescue female infertility. Purified hFSH glycoforms will also be tested in vivo using FSH null mice...
  11. Role of Serotonin in Mediating Stress-Induced Infertility
    Judy L Cameron; Fiscal Year: 2013
    ..women with Functional Hypothalamic Amenorrhea (FHA;a clinical condition which accounts for as much as 30% of female infertility) in which monkeys are exposed to a mild psychological stress (moving to a new room) and a moderate metabolic ..
  12. Prenatal androgen exposure: adverse effects and novel treatment strategies.
    FARAH H MORGAN; Fiscal Year: 2010
    ..disorders, such as polycystic ovarian syndrome (PCOS) affect 7-8% of women and are a leading cause of female infertility. PCOS is a complex heterogeneous disorder, characterized by excess activation of the reproductive ..
  13. Follicular and endometrial pathology in polycystic ovary syndrome
    ANNE ELIZABETH NEWELL-FUGATE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polycystic ovary syndrome (PCOS) is the most common cause of female infertility and results in a substantial financial burden to the American healthcare system...
  14. Progesterone control of diurnal GnRH pulses in puberty: impact of androgen excess
    Ruchi Bhabhra; Fiscal Year: 2013
    ..frequency LH (GnRH) pulse secretion, insulin resistance, metabolic syndrome and is the leading cause of female infertility. We propose the following aims to test our hypotheses...
  15. Insulin and Androgen Interactions in the Infertility of Obesity
    Sheng Wu; Fiscal Year: 2013
    ..Our laboratory has developed a diet-induced obesity (DIO) model of female infertility that shares many of the features of PCOS, infertility and hyperandrogenism in the setting of obesity...
  16. p63-Dependent Checkpoints in Oocytes
    Frank D McKeon; Fiscal Year: 2010
    ..will reveal much about how the oocyte maintains a high degree of genomic fidelity, how chemotherapy leads to female infertility, and insights into how the p53 family acts to eliminate cells with DNA damage to promote tumor suppression...
  17. Mitochondrial generation of superoxide in male reproduction
    Baisong Lu; Fiscal Year: 2010
    ..cl and affects the mitochondrial function such that the mutants develop normally but show male and female infertility. Al though the main mechanism for the infertility of mutant males is erectile dysfunction, mutant males ..
  18. GPR30 Mediated-Estrogen Action on Ovarian Physiology and Ovarian Cancer
    Cheng Wang; Fiscal Year: 2011
    ..However, many pathological conditions in the ovary result in female infertility and diseases such as ovarian cancer...
  19. Bisphenol A and Ovotoxicity
    Jodi A Flaws; Fiscal Year: 2013
    ..use of BPA raises concerns because developmental and postnatal exposures to BPA have been linked to female infertility in a variety of species...
  20. INSULIN AND THE POLYCYSTIC OVARY SYNDROME
    Kai I Cheang; Fiscal Year: 2010
    ..Relevance: PCOS is a major cause of female infertility. Insulin resistance plays an important role in the disorder...
  21. Sutureless Resorbable Anti-Adhesion Films
    MICHAEL J DANILICH; Fiscal Year: 2010
    ..Complications caused by adhesions include small bowel obstruction, female infertility, chronic debilitating pain, and difficulty in future operations...
  22. THE ROLE OF HORMAD1 IN GERM CELL DEVELOPMENT AND MEIOSIS
    Aleksandar Rajkovic; Fiscal Year: 2010
    ..the newly created Hormad1 knock-out mouse to delineate the onset of gonadal pathology that leads to male and female infertility. These studies will be important to begin understanding the function of the highly conserved HORMAD1 protein ..
  23. GPR30 Mediated-Estrogen Action on Ovarian Physiology and Ovarian Cancer
    Cheng Wang; Fiscal Year: 2013
    ..However, many pathological conditions in the ovary result in female infertility and diseases such as ovarian cancer...
  24. Cyclic AMP and the Control of the Meiotic Cell Cycle
    Marco Conti; Fiscal Year: 2010
    ..in vivo show that disruption in cAMP signaling in the oocytes is associated with reduced or complete female infertility and blockade in G2/M transition...
  25. Mechanisms of phthalate-induced ovarian follicle toxicity
    ZELIEANN RIVERA CRAIG; Fiscal Year: 2013
    ..Finally, results from this project will also contribute to research aimed at the identification of new treatments to reverse female infertility caused by environmental chemical exposure.
  26. Endothelin-2 in Ovarian Follicle Rupture
    Chemyong Ko; Fiscal Year: 2010
    ..The proposed experiments will provide clinical direction in identifying the therapeutic target for the cure of annovulatory symptoms, one of the leading causes of female infertility.
  27. Low-Cost Sprayable Barrier for the Prevention of Surgical Adhesions
    PATRICK STEVEN COTTLER; Fiscal Year: 2013
    ..surgery poses a significant health risk, cited as a leading cause of small bowel obstruction and female infertility. Methods to prevent these adhesions are currently limited to barrier films which are difficult to place and ..
  28. Coupling of D-chiro-inositol to insulin in PCOS women
    MARIA IUORNO; Fiscal Year: 2004
    ..PCOS) is characterized by hyperandrogenism and chronic anovulation and it is the most common form of female infertility in the U.S...
  29. Combination metformin and oral contraceptive for PCOS
    PAULINA ESSAH; Fiscal Year: 2006
    Polycystic ovary syndrome (PCOS) is the most common cause of female infertility in the United States...
  30. IMMUNOLOGIC MECHANISMS IN HUMAN FEMALE INFERTILITY
    John Herr; Fiscal Year: 2002
    ....
  31. UNDERSTANDING OVARIAN CONTROL IN RARE BIOMEDICAL MODELS
    KATHARINE PELICAN; Fiscal Year: 2006
    ..gonadotropin stimulation, 3) developing a research strategy for investigating complex mechanisms of female infertility, and 4) enhancing the efficiency of feline model propagation to ensure continued availability of cats for ..
  32. Ovarian Primordial Follicle Development
    Michael K Skinner; Fiscal Year: 2010
    ..therapeutic treatments for abnormal ovarian conditions such as premature ovarian failure (POF) and forms of female infertility. An example of a future experiment proposed is to determine if mutation(s) exist in any of the repertoire of ..
  33. Constitutively active LH receptors in transgenic mice
    Prema Narayan; Fiscal Year: 2007
    ..These studies will contribute new information on testicular and ovarian physiology and pathophysiology and provide insight into the molecular mechanisms of FMPP, female infertility and premature ovarian failure. [unreadable] [unreadable]
  34. DATA COORDINATING CENTER REPRODUCTIVE MEDICINE NETWORK
    Robert Canfield; Fiscal Year: 2000
    ..Medicine Network is designed to carry out large, multicenter clinical trials in the areas of male and female infertility and reproductive diseases and disorders...
  35. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    Joseph Hill; Fiscal Year: 1999
    ..Medicine Network is designed to carry out large, multicenter clinical trials in the areas of male and female infertility and reproductive diseases and disorders...
  36. Physiology & Action of a New Follistatin-Related Protein
    Alan Schneyer; Fiscal Year: 2005
    ..Overexpression of FSRP in transgenic mice disrupts follicular development, resulting in female infertility. Thus, the broad goal of this proposal is to determine the biological functions of FSRP in normal and ..
  37. PITUITARY TUMORS--PATHOGENESIS AND CELLULAR FUNCTION
    THOMAS CROXTON; Fiscal Year: 1993
    Excess secretion of prolactin (PRL) a common cause of female infertility, is usually associated with an anterior pituitary prolactinoma...
  38. INOSITOL GLYCAN MEDIATORS IN POLYCYSTIC OVARY SYNDROME
    Geoffrey Allan; Fiscal Year: 1999
    ..PCOS is characterized by hyperandrogenism and anovulation, and is the primary cause of female infertility in the United States...
  39. GONADAL AND ENDOMETRIAL FUNCTION IN HUMAN REPRODUCTION
    Renee Reijo Pera; Fiscal Year: 2007
    ..Issues of female infertility and fertility are critical to the national agenda to improve women's health care...
  40. Inflammation: Effect on Insulin Resistance in PCOS
    Frank Gonzalez; Fiscal Year: 2007
    ..of unknown etiology that affects as many as 8% of the female population and is the most common cause of female infertility. The chronic anovulation and hyperandrogenism characteristic of PCOS is promulgated by insulin resistance ..
  41. Bioabsorbable Membranes for Prevention of Adhesions
    Dufei Fang; Fiscal Year: 2007
    ..the trauma of surgery and can lead to serious complications, including pelvic pain, small bowel obstruction, female infertility, chronic debilitating pain and difficulty with future operations...
  42. BIOLOGY OF PHAGE INFECTION IN CHLAMYDIA
    Patrik Bavoil; Fiscal Year: 2005
    ..predominant ocular, genital and respiratory tract infections, with sequelae ranging from blindness, to female infertility, arthritis and asthma...
  43. ABSORBABLE STENT FOR REANASTOMOSIS OF THE FALLOPIAN TUBE
    JOHN JESSEN; Fiscal Year: 1993
    ..Our overall goal is to provide devices that will improve the effectiveness and reduce the skill, time and cost of tubal reconstructive surgery, thereby contributing to overall improvement of female infertility therapy.
  44. Transdermal GnRH Delivery System to Treat Infertility
    Kenneth Swartz; Fiscal Year: 2006
    ..One of the most common causes of female infertility is anovulation, or the inability to stimulate and release an egg from the ovary...
  45. BIOPSYCHOSOCIAL PREDICTORS OF ADOLESCENT SEXUAL BEHAVIOR
    Mary Ann Shafer; Fiscal Year: 1990
    ..of ectopic pregnancy and pelvic inflammatory disease (PID) have been documented as the major cause of female infertility. Sexually active adolescent females are recognized as the most at risk population for PID and STDs including ..
  46. Regulation of Ovarian Follicle Activation
    DIEGO CASTRILLON; Fiscal Year: 2009
    ..An improved understanding of this pathway will lead to insights into the biological and genetic basis of female infertility, create significant opportunities to develop predictive genetic tests for hereditary forms of female ..
  47. Psychosocial Impact of Cancer-Related Female Infertility
    ANDREA CANADA; Fiscal Year: 2005
    ..We plan to use these data to create an intervention to reduce distress and provide information to women whose childbearing is interrupted by cancer. ..
  48. IMMUNOBIOLOGY OF REPRODUCTION
    JOAN HUNT; Fiscal Year: 1993
    ..histocompatibility complex genes, (V) experimental models, and (VI) auto- and alloimmune aspects of male and female infertility. The format is designed so as to integrate recent findings in basic and clinical research...
  49. Neuroendo Signal Transduction in Reproductive Physiology
    KAREN GREGERSON; Fiscal Year: 2007
    ..Hypersecretion of PRL is the major neuroendocrine-related pathology associated with female infertility. Isolated PRL deficiency, while rare, also results in reduced fertility and lactational failure in women...
  50. Molecular Aspects of Implantation
    Kelle Moley; Fiscal Year: 2006
    ..studies will provide novel information regarding the unique role of PPARdelta and will advance our understanding in human reproduction with potentials in alleviating female infertility and development of contraceptives.
  51. Identification of the chlamydial anti-apoptosis factor
    Ana Gervassi; Fiscal Year: 2006
    ..are responsible for several diseases of public health importance, including pelvic inflammatory disease, female infertility, blindness, arthritis and possibly cancer, asthma, and coronary heart disease...
  52. INSULIN RESISTANCE IN PCOS--SEQUELAE AND TREATMENT
    RICHARD LEGRO; Fiscal Year: 2005
    ..Improving insulin action through diet and exercise, with and without weight loss, will result in lowered circulating insulin levels, lowered androgens and increased ovulatory frequency rate in PCOS women. ..
  53. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2004
    ..Therefore, the risks and benefits of a CCOCP regimen are an important women's health issue that warrant investigation. ..
  54. Role of integrins and activin in granulosa cell growth
    Kutluk Oktay; Fiscal Year: 2007
    ..Cell proliferation and survival will be determined before and after transfection with the dominant-negative mutants. ..
  55. COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK
    PETER MCGOVERN; Fiscal Year: 2004
    ..We will then test the hypothesis that this novel protocol, by preventing the hypersecretion of luteal products in gonadotropin-induced pregnancies, will result in safer infertility therapy. ..
  56. A Community Study of Infertility in Northern Tanzania
    Ulla Larsen; Fiscal Year: 2004
    ..A basic protocol for the recommended treatment of infertility will be developed. 6. To analyze the social implications of infertility. 7. To assess the demographic implications of infertility. ..
  57. A prospective study of diet and endometriosis
    Stacey Missmer; Fiscal Year: 2006
    ..These analyses will be the first to evaluate the relation between these dietary factors and this important and understudied cause of morbidity among premenopausal women. [unreadable] [unreadable]..
  58. HORMONES, BRAIN FUNCTION, AND BEHAVIOR
    George Wade; Fiscal Year: 2007
    ..A third proposed line of research examines the effects of metabolic fuel availability on matern',_ behavior in hamsters. ..
  59. Immunobiological Role of Fertilization Antigen(FA-1)
    RAJESH NAZ; Fiscal Year: 2007
    ..unreadable] [unreadable]..