infertility

Summary

Summary: Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility.

Top Publications

  1. ncbi Infertility and assisted reproduction in Denmark. Epidemiology and psychosocial consequences
    Lone Schmidt
    University of Copenhagen, Faculty of Health Sciences, Institute of Public Health, Department of Social Medicine, Denmark
    Dan Med Bull 53:390-417. 2006
  2. ncbi Definition and prevalence of subfertility and infertility
    C Gnoth
    Center for Family Planning, Gynaecological Endocrinology and Reproductive Medicine Grevenbroich, Heinrich Heine University of Duesseldorf, Germany
    Hum Reprod 20:1144-7. 2005
  3. pmc The biology of infertility: research advances and clinical challenges
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Nat Med 14:1197-213. 2008
  4. pmc Late-acting dominant lethal genetic systems and mosquito control
    Hoang Kim Phuc
    Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
    BMC Biol 5:11. 2007
  5. pmc National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys
    Maya N Mascarenhas
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    PLoS Med 9:e1001356. 2012
  6. pmc Infertility, infertility treatment, and congenital malformations: Danish national birth cohort
    Jin Liang Zhu
    Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMJ 333:679. 2006
  7. ncbi Pathogenesis of infertility and recurrent pregnancy loss in thyroid autoimmunity
    Gilad Twig
    Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    J Autoimmun 38:J275-81. 2012
  8. ncbi Positional cloning and characterization of mouse mei8, a disrupted allelle of the meiotic cohesin Rec8
    Laura A Bannister
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Genesis 40:184-94. 2004
  9. ncbi Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination
    Ekaterina Revenkova
    Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Cell Biol 6:555-62. 2004
  10. ncbi Tackling burden in ART: an integrated approach for medical staff
    Jacky Boivin
    Cardiff Fertility Studies Research Group, School of Psychology, Cardiff University, Tower Building, Park Place, CF10 3AT, Cardiff, Wales, UK
    Hum Reprod 27:941-50. 2012

Detail Information

Publications311 found, 100 shown here

  1. ncbi Infertility and assisted reproduction in Denmark. Epidemiology and psychosocial consequences
    Lone Schmidt
    University of Copenhagen, Faculty of Health Sciences, Institute of Public Health, Department of Social Medicine, Denmark
    Dan Med Bull 53:390-417. 2006
    ..There was scant knowledge about the prevalences of infertility, involuntary childlessness and the seeking of fertility treatment and only few longitudinal studies about the ..
  2. ncbi Definition and prevalence of subfertility and infertility
    C Gnoth
    Center for Family Planning, Gynaecological Endocrinology and Reproductive Medicine Grevenbroich, Heinrich Heine University of Duesseldorf, Germany
    Hum Reprod 20:1144-7. 2005
    A common definition of sub- and infertility is very important for the appropriate management of infertility. Subfertility generally describes any form of reduced fertility with prolonged time of unwanted non-conception...
  3. pmc The biology of infertility: research advances and clinical challenges
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA
    Nat Med 14:1197-213. 2008
    ..However, many infertile couples continue to be labeled with the diagnosis of idiopathic infertility or given descriptive diagnoses that do not provide a cause for their defect...
  4. pmc Late-acting dominant lethal genetic systems and mosquito control
    Hoang Kim Phuc
    Department of Zoology, University of Oxford, South Parks Road, Oxford, UK
    BMC Biol 5:11. 2007
    ..Additionally, vector populations with strong density-dependent effects will tend to be resistant to SIT-based control as the population-reducing effect of induced sterility will tend to be offset by reduced density-dependent mortality...
  5. pmc National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys
    Maya N Mascarenhas
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    PLoS Med 9:e1001356. 2012
    Global, regional, and national estimates of prevalence of and tends in infertility are needed to target prevention and treatment efforts...
  6. pmc Infertility, infertility treatment, and congenital malformations: Danish national birth cohort
    Jin Liang Zhu
    Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, DK 8000 Aarhus C, Denmark
    BMJ 333:679. 2006
    ..To examine whether infertile couples (with a time to pregnancy of > 12 months), who conceive naturally or after treatment, give birth to children with an increased prevalence of congenital malformations...
  7. ncbi Pathogenesis of infertility and recurrent pregnancy loss in thyroid autoimmunity
    Gilad Twig
    Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    J Autoimmun 38:J275-81. 2012
    ..A growing body of clinical studies links thyroid autoimmunity as a cause of infertility and adverse pregnancy outcomes that includes miscarriage or preterm deliveries...
  8. ncbi Positional cloning and characterization of mouse mei8, a disrupted allelle of the meiotic cohesin Rec8
    Laura A Bannister
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Genesis 40:184-94. 2004
    A novel mutation, mei8, was isolated in a forward genetic screen for infertility mutations induced by chemical mutagenesis of ES cells. Homozygous mutant mice are sterile...
  9. ncbi Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination
    Ekaterina Revenkova
    Center for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Nat Cell Biol 6:555-62. 2004
    ..Thus, SMC1 beta has a key role in meiotic cohesion, the assembly of AEs, synapsis, recombination, and chromosome movements...
  10. ncbi Tackling burden in ART: an integrated approach for medical staff
    Jacky Boivin
    Cardiff Fertility Studies Research Group, School of Psychology, Cardiff University, Tower Building, Park Place, CF10 3AT, Cardiff, Wales, UK
    Hum Reprod 27:941-50. 2012
    ..Reducing the burden of treatment should lead to improved outcomes, namely better quality of life during treatment and lower discontinuation rates...
  11. ncbi Chlamydia infection, pelvic inflammatory disease, ectopic pregnancy and infertility: cross-national study
    Nicole Bender
    Institute of Social and Preventive Medicine, University of Bern, Bern CH 3012, Switzerland
    Sex Transm Infect 87:601-8. 2011
    ..countries, chlamydia control activities and rates of chlamydia infection, pelvic inflammatory disease (PID), ectopic pregnancy and infertility and to compare trends in chlamydia positivity with rates of PID and ectopic pregnancy.
  12. pmc Mechanistic basis of infertility of mouse intersubspecific hybrids
    Tanmoy Bhattacharyya
    Mouse Molecular Genetics Group, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic
    Proc Natl Acad Sci U S A 110:E468-77. 2013
    ..It is tempting to speculate that a fast-evolving subset of the noncoding genomic sequence important for chromosome pairing and synapsis may be the culprit...
  13. pmc The use of complementary and alternative fertility treatment in couples seeking fertility care: data from a prospective cohort in the United States
    James F Smith
    Department of Urology, University of California, San Francisco, California 94143 1695, USA
    Fertil Steril 93:2169-74. 2010
    ..To determine the prevalence of complementary and alternative medicine (CAM) use among couples seeking fertility care and to identify the predictors of CAM use in this population...
  14. ncbi Defining infertility--a systematic review of prevalence studies
    S Gurunath
    Obstetrics and Gynaecology, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK
    Hum Reprod Update 17:575-88. 2011
    Existing definitions of infertility lack uniformity, rendering comparisons in prevalence between countries or over time problematic...
  15. ncbi 'You are a man because you have children': experiences, reproductive health knowledge and treatment-seeking behaviour among men suffering from couple infertility in South Africa
    S J Dyer
    Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa
    Hum Reprod 19:960-7. 2004
    In Africa, infertility traditionally has been viewed as a female problem...
  16. pmc Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis
    Eric Manheimer
    Center for Integrative Medicine, University of Maryland School of Medicine, 2200 Kernan Drive, Kernan Hospital Mansion, Baltimore, MD 21207, USA
    BMJ 336:545-9. 2008
    ..To evaluate whether acupuncture improves rates of pregnancy and live birth when used as an adjuvant treatment to embryo transfer in women undergoing in vitro fertilisation...
  17. pmc Wolbachia and cytoplasmic incompatibility in the California Culex pipiens mosquito species complex: parameter estimates and infection dynamics in natural populations
    Jason L Rasgon
    Department of Entomology, University of California, Davis, California 95616, USA
    Genetics 165:2029-38. 2003
    ..If certain technical hurdles can be overcome, our data indicate that Wolbachia can invade vector populations as part of an applied transgenic strategy for vector-borne disease reduction...
  18. pmc Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?
    Leigh R Guerin
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, SA 5005, Australia
    Hum Reprod Update 15:517-35. 2009
    ..fetus is necessary for pregnancy success, and disturbances in maternal tolerance are implicated in infertility and reproductive pathologies...
  19. ncbi Investigation into effectiveness of counseling on assisted reproductive techniques in Turkey
    F Terzioglu
    Hacettepe University School of Nursing, Department of Obstetrics and Women s Health Nursing, Ankara, Turkey
    J Psychosom Obstet Gynaecol 22:133-41. 2001
    ....
  20. pmc Complementary and alternative medicine utilization by a sample of infertile couples in Jordan for infertility treatment: clinics-based survey
    Sanaa K Bardaweel
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Queen Rania Street, Amman 11942, Jordan
    BMC Complement Altern Med 13:35. 2013
    ..and alternative medicine (CAM), growing evidence suggests that CAM prevalence among patients seeking infertility treatment is increasing worldwide...
  21. ncbi The fertility myth: Israeli students' knowledge regarding age-related fertility decline and late pregnancies in an era of assisted reproduction technology
    Yael Hashiloni-Dolev
    School of Government and Society, The Academic College of Tel Aviv Yaffo, Rabenu Yeruham St, POB 8401, 61083 Yaffo, Israel
    Hum Reprod 26:3045-53. 2011
    ....
  22. ncbi Using focus groups with minority ethnic communities: Researching infertility in British South Asian communities
    Lorraine Culley
    De Montfort University, Leicester, United Kingdom
    Qual Health Res 17:102-12. 2007
    ..In this article, the authors discuss the use of this method in a study of the provision of infertility services to South Asian communities in three English cities...
  23. ncbi Lysophospholipids: potential markers of diseases and infertility?
    B Fuchs
    Institute of Medical Physics and Biophysics, University of Leipzig, Leipzig, Germany
    Mini Rev Med Chem 12:74-86. 2012
    ..Finally, the effects of LPL as signaling molecules and their roles in different pathologies such as infertility, cancer, atherosclerosis or inflammatory diseases are discussed...
  24. ncbi Time to pregnancy: results of the German prospective study and impact on the management of infertility
    C Gnoth
    Department of Reproductive Medicine and Gynaecological Endocrinology, Staedtische Kliniken Duesseldorf gGmbH, Frauenklinik Benrath, Germany
    Hum Reprod 18:1959-66. 2003
    The likelihood of spontaneous conception in subsequent cycles is important for a balanced management of infertility. Previous studies on time to pregnancy are mostly retrospective and biased because of exclusion of truly infertile ..
  25. pmc Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
    Carl De Luca
    Department of Medicine, Division of Preventative Medicine, Columbia University, New York, New York, USA
    J Clin Invest 115:3484-93. 2005
    ..In summary, we show that brain-specific leptin signaling is sufficient to reverse the obesity, diabetes, and infertility of db/db mice.
  26. doi ESHRE Task Force on Ethics and Law 14: equity of access to assisted reproductive technology
    G Pennings
    Hum Reprod 23:772-4. 2008
    ..This paper analyses this question not only for people suffering from infertility, but also for people who need assistance to prevent the birth of a child with a specific genetic disorder...
  27. pmc Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility
    Xiaoping Ma
    Departments of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:17294-9. 2004
    ..LHbeta-null mice are viable but demonstrate postnatal defects in gonadal growth and function resulting in infertility. Mutant males have decreased testes size, prominent Leydig cell hypoplasia, defects in expression of genes ..
  28. ncbi Crossing borders for fertility treatment: motivations, destinations and outcomes of UK fertility travellers
    L Culley
    School of Applied Social Sciences, De Montfort University, Hawthorn Building, The Gateway, Leicester LE1 9BH, UK
    Hum Reprod 26:2373-81. 2011
    ....
  29. pmc Asymmetric postmating isolation: Darwin's corollary to Haldane's rule
    Michael Turelli
    Section of Evolution and Ecology, University of California, Davis, California 95616, USA
    Genetics 176:1059-88. 2007
    ..Comparing our predictions to data from diverse taxa indicates that unidirectional DMIs, specifically involving sex chromosomes, cytoplasmic elements, and maternal effects, are likely to play an important role in postmating isolation...
  30. pmc Estimating the prevalence of infertility in Canada
    Tracey Bushnik
    Health Analysis Division, Statistics Canada, Ottawa, Canada K1A 0T6
    Hum Reprod 27:738-46. 2012
    ..use of assisted reproductive technologies in Canada, however, little is known about the overall prevalence of infertility in the population...
  31. ncbi Right to assisted reproductive technology: overcoming infertility in low-resource countries
    Marcia C Inhorn
    Department of Anthropology, Yale University, New Haven, CT 06520, USA
    Int J Gynaecol Obstet 106:172-4. 2009
    This article examines the high prevalence of primary and secondary infertility in low-resource countries...
  32. ncbi Reproductive healthcare systems should include accessible infertility diagnosis and treatment: an important challenge for resource-poor countries
    Willem Ombelet
    Department of Obstetrics and Gynecology, Genk Institute for Fertility Technology, 3600 Genk, Belgium
    Int J Gynaecol Obstet 106:168-71. 2009
    b>Infertility is a central issue in the lives of many couples who suffer from it...
  33. ncbi Current Internet use and preferences of IVF and ICSI patients
    E C Haagen
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Hum Reprod 18:2073-8. 2003
    ..The study aim was to characterize current Internet use by IVF and ICSI patients and to identify their preferences regarding Internet applications in fertility care...
  34. pmc Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples
    M Ludwig
    Endokrinologikum Hamburg, Hamburg, Germany
    J Med Genet 42:289-91. 2005
    Recent case reports have suggested that infertility treatment with intracytoplasmic sperm injection (ICSI) may increase the risk of imprinting defects leading to Angelman syndrome (AS)...
  35. ncbi Measuring patient-centredness, the neglected outcome in fertility care: a random multicentre validation study
    Inge W H van Empel
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Reprod 25:2516-26. 2010
    ..This study aims to develop and validate an instrument that can reliably measure patient-centredness in fertility care: patient-centredness questionnaire-infertility (PCQ-infertility).
  36. ncbi Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility
    Cheng Wang
    Department of Clinical Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing, China
    Clin Chem 57:1722-31. 2011
    ..We investigated the profile of seminal plasma miRNAs in infertile men to identify miRNAs that are altered in infertility; we then evaluated their diagnostic value.
  37. pmc The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders
    Emily Northrup
    Institute of Laboratory Animal Science, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e38001. 2012
    ..Teratocarcinogenesis was accompanied by infertility and the underlying mutation was termed ter...
  38. ncbi Distress and concerns in couples referred to a specialist infertility clinic
    K M Anderson
    Department of Psychiatry, Royal Victoria Hospital, 13 Craigleith Road, Edinburgh EH4 2DN, UK
    J Psychosom Res 54:353-5. 2003
    The aims of this study were to examine emotional distress and infertility-related concerns in male and female members of couples referred to a specialist infertility clinic and to determine changes in these over time.
  39. ncbi Assisted reproductive technologies (ART) in Canada: 2007 results from the Canadian ART Register
    Joanne Gunby
    Pegasus Technologies, Burlington, Ontario, Canada
    Fertil Steril 95:542-7.e1-10. 2011
    ..To present a report on assisted reproductive technologies (ART) cycles performed in 2007 in Canada and show trends in outcomes over time. This is the seventh annual report from the Canadian ART Register (CARTR)...
  40. pmc Behavioral and spermatogenic hybrid male breakdown in Nasonia
    M E Clark
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Heredity (Edinb) 104:289-301. 2010
    ..add to previous studies of F2 hybrid inviability and behavioral sterility, and indicate that Wolbachia-induced hybrid incompatibility has arisen early in species divergence, relative to behavioral sterility and spermatogenic infertility.
  41. ncbi Extent of acupuncture practice for infertility in the United Kingdom: experiences and perceptions of the practitioners
    Mark Bovey
    Acupuncture Research Resource Centre, Thames Valley University, Brentford, Middlesex, United Kingdom
    Fertil Steril 94:2569-73. 2010
    ..To investigate acupuncture practitioners' experience and perceptions of supporting patients presenting with fertility issues...
  42. ncbi Infertility patients' beliefs about their embryos and their disposition preferences
    V Provoost
    Bioethics Institute Ghent, Ghent University, Blandijnberg 2 B 9000 Ghent, Belgium
    Hum Reprod 24:896-905. 2009
    Little research has been done on how beliefs of infertility patients about their embryos are related to their disposition decisions. The objective of this study was to describe how patients speak about their embryos, in moral (e.g...
  43. pmc Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely
    Sungeun Lee
    Division of Reproductive Sciences, Department of Clinical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    Endocrinology 150:3855-62. 2009
    ..Taken together, this study demonstrates that theca Esr1 plays a critical role in regulating female reproduction...
  44. ncbi External validation of nomogram for the decline in serum anti-Müllerian hormone in women: a population study of 15,834 infertility patients
    Scott M Nelson
    Centre for Population and Health Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Reprod Biomed Online 23:204-6. 2011
    ..This nomogram can therefore be used with confidence for the interpretation of AMH in clinical populations...
  45. ncbi Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue
    Claus Yding Andersen
    Laboratory of Reproductive Biology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 23:2266-72. 2008
    ..The present study reports ovarian activity and pregnancies following autotransplantation of frozen/thawed ovarian tissue...
  46. ncbi Quality of infertility care in poor-resource areas and the introduction of new reproductive technologies
    F van Balen
    Department of Education, Faculty of Social and Behavioural Sciences, University of Amsterdam, PO Box 94208 1090 GE Amsterdam, The Netherlands
    Hum Reprod 16:215-9. 2001
    The quality of infertility care is dependent upon adequate material resources and the appropriate use of it. In addition, a mutual understanding between physicians and patients is necessary...
  47. ncbi Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation
    Jan Tesarik
    MAR and Gen, Molecular Assisted Reproduction and Genetics, Gracia 36, 18002 Granada, Spain
    Hum Reprod 19:611-5. 2004
    ..It is known that repeated failure of assisted reproduction treatment (ART) can be due to a paternal effect. This study was undertaken to analyse the possible relationship between ART failure and sperm DNA fragmentation...
  48. ncbi Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility
    Michail Nomikos
    Cell Signalling Laboratory, WHRI, Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, UK
    Bioessays 34:126-34. 2012
    ..Recent advances have refined our understanding of how PLCζ induces Ca(2+) oscillations in the egg and also suggest its potential dysfunction as a cause of male infertility.
  49. pmc Infertility and the provision of infertility medical services in developing countries
    Willem Ombelet
    Department of Obstetrics and Gynaecology, Genk Institute for Fertility Technology, Schiepse Bos 6, 3600 Genk, Belgium
    Hum Reprod Update 14:605-21. 2008
    Worldwide more than 70 million couples suffer from infertility, the majority being residents of developing countries...
  50. ncbi The use of complementary medicine and therapies by patients attending a reproductive medicine unit in South Australia: a prospective survey
    Marcin Stankiewicz
    Department of Obstetrics Gynaecology and Reproductive Medicine, Flinders Medical Centre, South Australia, Australia
    Aust N Z J Obstet Gynaecol 47:145-9. 2007
    There is limited research describing the use of complementary medicines (CM) and therapies among patients with infertility.
  51. ncbi Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis
    L L van Loendersloot
    Department of Obstetrics and Gynaecology, Centre for Reproductive Medicine, Meibergdreef 9, Amsterdam, The Netherlands
    Hum Reprod Update 16:577-89. 2010
    ..These models differ from one another in the predictors they include. We performed a systematic review and meta-analysis to identify the most relevant predictors for success in IVF...
  52. ncbi Reasons for discontinuation of IVF treatment: a questionnaire study
    M Rajkhowa
    Assisted Conception Unit, Ninewells Hospital and Medical School, Dundee, UK
    Hum Reprod 21:358-63. 2006
    IVF and embryo transfer has become an established and increasingly successful form of treatment for infertility, yet significant numbers of couples discontinue treatment without achieving a live birth...
  53. pmc A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory
    David J Katz
    Biology Department, Emory University, Atlanta, GA 30322, USA
    Cell 137:308-20. 2009
    ..Thus, our results provide direct mechanistic insights into the processes that are required for epigenetic reprogramming between generations...
  54. ncbi Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death
    M T Wiekowski
    Department of Immunology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    J Immunol 166:7563-70. 2001
    ..tissues of transgenic mice induced a striking phenotype characterized by runting, systemic inflammation, infertility, and death before 3 mo of age...
  55. ncbi Real-time fine morphology of motile human sperm cells is associated with IVF-ICSI outcome
    Benjamin Bartoov
    Male Fertility Laboratory, Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Androl 23:1-8. 2002
    ..These findings indicate that ICSI-associated pregnancy rate may be affected by subtle morphological malformations of the sperm nucleus, which may remain undetected by the embryologist during the routine selection procedure...
  56. ncbi Pregnancy is predictable: a large-scale prospective external validation of the prediction of spontaneous pregnancy in subfertile couples
    J W van der Steeg
    Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Hum Reprod 22:536-42. 2007
    ..We assessed the accuracy of a recently published prediction model for spontaneous pregnancy in a large prospective validation study...
  57. pmc Sex chromosomes and speciation in Drosophila
    Daven C Presgraves
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Trends Genet 24:336-43. 2008
    ..Several other new findings -- on faster X evolution, X chromosome meiotic drive and the regulation of the X chromosome in the male-germline -- provide plausible evolutionary explanations for the large X-effect...
  58. ncbi When and why do subfertile couples discontinue their fertility care? A longitudinal cohort study in a secondary care subfertility population
    M Brandes
    Department of Obstetrics and Gynaecology, Jeroen Bosch Ziekenhuis, PO Box 90153, 5200 ME s Hertogenbosch, The Netherlands
    Hum Reprod 24:3127-35. 2009
    ..A substantial number of subfertile couples discontinues fertility care before achieving pregnancy. Most studies on dropouts are related to IVF. The aim here is to examine dropout rates at all stages of fertility care...
  59. ncbi A review of psychosocial interventions in infertility
    J Boivin
    School of Psychology, Cardiff University, Cardiff CF10 3YG, UK
    Soc Sci Med 57:2325-41. 2003
    ..which emphasised emotional expression and support and/or discussion about thoughts and feelings related to infertility. Men and women were found to benefit equally from psychosocial interventions...
  60. ncbi Health seeking behaviour of childless women in Bangladesh: an ethnographic exploration for the special issue on: loss in child bearing
    Papreen Nahar
    Department of Anthropology, Durham University, Durham, UK
    Soc Sci Med 71:1780-7. 2010
    ..Consequently the childless women have to suffer in various ways as a result of their health seeking behaviour...
  61. pmc Cumulative ongoing pregnancy rate achieved with oocyte vitrification and cleavage stage transfer without embryo selection in a standard infertility program
    Filippo Ubaldi
    G EN E R A Centre for Reproductive Medicine, Clinica Valle Giulia, Via G De Notaris 2, 00197 Rome, Italy
    Hum Reprod 25:1199-205. 2010
    ....
  62. ncbi Environmental contaminants and human infertility: hypothesis or cause for concern?
    Warren G Foster
    Centre for Reproductive Care and Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    J Toxicol Environ Health B Crit Rev 11:162-76. 2008
    ..tissues, together with reports of a global decline in semen quality, further fueled speculation that human infertility rates are increasing and environmental toxicants are potentially important causal agents associated with this ..
  63. ncbi Discussion of fertility preservation with newly diagnosed patients: oncologists' views
    Gwendolyn P Quinn
    Department of Interdisciplinary Oncology, College of Medicine, University of South Florida, Tampa, FL, USA
    J Cancer Surviv 1:146-55. 2007
    ..This qualitative study sought to identify current physician FP communication practices and determine factors that may impact communication efforts regarding FP...
  64. ncbi Infertility knowledge and attitudes in urban high school students
    Susan Quach
    Create IVF Program, The Sunnybrook and Women s College Hospital Fertility Centre, Toronto, Ontario, Canada
    Fertil Steril 90:2099-106. 2008
    To assess knowledge and attitudes about infertility through a survey.
  65. ncbi Insurance mandates and trends in infertility treatments
    Melinda B Henne
    Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Washington, DC 20307, USA
    Fertil Steril 89:66-73. 2008
    ..To examine the relationship between insurance mandates and the utilization and outcomes of assisted reproductive technologies (ART)...
  66. ncbi Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia
    M Chen
    Department of Genetics, Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Genet 12:448-51. 1996
    ..Homozygous male and female mice also had compromised gametogenesis, leading to markedly impaired fertility, a characteristic of FA patients. Thus, inactivation of Fac replicates some of the features of the human disease...
  67. ncbi Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity
    Meen Yau Thum
    Lister Fertility Clinic, Lister Hospital, London, UK
    Am J Reprod Immunol 59:259-65. 2008
    ..To evaluate the effect of prednisolone on NK cell cytotoxicity in vitro environment and also to compare the effect of prednisolone versus immunoglobulin-G (IVIG) on NK cell cytotoxicity using in vitro co-culture with K562 cells...
  68. ncbi Genomic imprinting and its relevance to congenital disease, infertility, molar pregnancy and induced pluripotent stem cell
    Shin Ichi Tomizawa
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    J Hum Genet 57:84-91. 2012
    ..More severe disruptions can lead to recurrent molar pregnancy, miscarriage or infertility. Imprinting defects may also occur during assisted reproductive technology or cell reprogramming...
  69. ncbi Nomogram for the decline in serum antimüllerian hormone: a population study of 9,601 infertility patients
    Scott M Nelson
    Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, Scotland
    Fertil Steril 95:736-41.e1-3. 2011
    ..To define an optimal model for the decline in circulating antimüllerian hormone (AMH) with age and develop a validated age-related nomogram...
  70. ncbi Bioethical dilemmas of assisted reproduction in the opinions of Polish women in infertility treatment: a research report
    Aleksandra Dembinska
    Social Sciences Institute, Katowice School of Economics, Harcerzy Września 3, Katowice 40 659, Poland
    J Med Ethics 38:731-4. 2012
    b>Infertility Accepted treatment is replete with bioethical dilemmas regarding the limits of available medical therapies...
  71. pmc Infertility, infertility treatment and twinning: the Danish National Birth Cohort
    Jin Liang Zhu
    Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus C, Denmark
    Hum Reprod 22:1086-90. 2007
    ..time to pregnancy (TTP) is associated with a reduced frequency of twin deliveries in couples not receiving infertility treatment...
  72. ncbi Psychosocial characteristics of infertile couples: a study by the 'Heidelberg Fertility Consultation Service'
    T Wischmann
    Department of Medical Psychology, Psychosomatic Hospital, University of Heidelberg, Heidelberg, Germany
    Hum Reprod 16:1753-61. 2001
    The aim of the study was to identify differences in psychological characteristics between couples with fertility disorders, especially idiopathic infertility, and a representative sample.
  73. pmc History and challenges surrounding ovarian stimulation in the treatment of infertility
    Stephanie A Beall
    Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1109, USA
    Fertil Steril 97:795-801. 2012
    ..To examine the history of superovulation for ovulation induction, its contributions to reproductive medicine, and its impact on multiple births...
  74. ncbi Genetic investigations of CFTR mutations in congenital absence of vas deferens, uterus, and vagina as a cause of infertility
    Ramin Radpour
    Laboratory for Prenatal Medicine and Gynecologic Oncolocy, Women s Hospital Department of Medicine, University of Basel, Switzerland
    J Androl 29:506-13. 2008
    A qualitative diagnosis of infertility requires attention to male and female physical abnormalities including endocrine anomalies and genetic conditions that interfere with reproduction...
  75. ncbi Physicians underestimate the importance of patient-centredness to patients: a discrete choice experiment in fertility care
    Inge W H van Empel
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Reprod 26:584-93. 2011
    ..This study aimed to determine and compare the importance of patient-centredness, relative to pregnancy rates, to patients and physicians...
  76. ncbi 'Mama and papa nothing': living with infertility among an urban population in Kigali, Rwanda
    N Dhont
    International Centre for Reproductive Health, Ghent University, Ghent, Belgium
    Hum Reprod 26:623-9. 2011
    Not being able to procreate has severe social and economic repercussions in resource-poor countries. The purpose of this research was to explore the consequences of female and/or male factor infertility for men and women in Rwanda.
  77. ncbi Serum unconjugated bisphenol A concentrations in women may adversely influence oocyte quality during in vitro fertilization
    Victor Y Fujimoto
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94115 0916, USA
    Fertil Steril 95:1816-9. 2011
    ..Our data indicate that BPA exposure in female patients may interfere with oocyte quality during IVF, as suggested by the inverse association between serum unconjugated BPA concentration and normal fertilization...
  78. ncbi Attitudes of couples with stored frozen embryos toward conditional embryo donation
    Catherine A McMahon
    Psychology Department, Macquarie University, North Ryde, New South Wales, Australia
    Fertil Steril 91:140-7. 2009
    ..To survey clients with stored frozen embryos regarding intention to donate embryos to other couples and attitudes toward conditional donation...
  79. ncbi Patients' attitudes towards donation of surplus cryopreserved embryos for treatment or research
    S Bangsbøll
    The Fertility Clinic and Laboratory of Reproductive Biology, Copenhagen University Hospital, Copenhagen, Denmark
    Hum Reprod 19:2415-9. 2004
    ..The aim of the study was 2-fold: first, to investigate couples' reasons for not using cryopreserved embryos within the maximum storage period; second, to study their attitudes towards potential embryo donation for specific purposes...
  80. ncbi Ex vivo early embryo development and effects on gene expression and imprinting
    David K Gardner
    Colorado Center for Reproductive Medicine, Englewood, 80113, USA
    Reprod Fertil Dev 17:361-70. 2005
    ..Alternatively, it may be that epigenetic alterations are associated with infertility and symptoms are subsequently revealed through ART...
  81. ncbi Micronuclei and their association with sperm abnormalities, infertility, pregnancy loss, pre-eclampsia and intra-uterine growth restriction in humans
    Michael Fenech
    CSIRO Food and Nutritional Sciences, Gate 13, Kintore Avenue, Adelaide SA 5000, Australia
    Mutagenesis 26:63-7. 2011
    The micronucleus (MN) assay is increasingly being used to study the association between DNA damage and infertility or pregnancy complications in humans. This review provides a brief overview of the studies published to date...
  82. ncbi Acupuncture on the day of embryo transfer: a randomized controlled trial of 635 patients
    Dorthe Andersen
    The Fertility Clinics, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
    Reprod Biomed Online 21:366-72. 2010
    ..The differences were not statistically significant. These results suggest that acupuncture administered in relation to embryo transfer has no effect on the outcome of IVF and ICSI...
  83. ncbi Assisted reproductive technologies (ART) in Canada: 2006 results from the Canadian ART Register
    Joanne Gunby
    Pegasus Technologies, Burlington, Ontario, Canada
    Fertil Steril 93:2189-201. 2010
    ..To present a report on assisted reproductive technologies (ART) cycles performed in 2006 in Canada and show trends in outcomes over time. This is the sixth annual report from the Canadian ART Register (CARTR)...
  84. ncbi American Society of Clinical Oncology recommendations on fertility preservation in cancer patients
    Stephanie J Lee
    Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 24:2917-31. 2006
    ..To develop guidance to practicing oncologists about available fertility preservation methods and related issues in people treated for cancer...
  85. ncbi Information provision and decision-making in assisted reproduction treatment: results from a survey in Germany
    O Rauprich
    Institute for Medical Ethics and History of Medicine, Ruhr Universitat Bochum, Bochum, Germany
    Hum Reprod 26:2382-91. 2011
    ..The objective of this study was to investigate the views of patients and experts in Germany on information provision and decision-making in assisted reproduction treatment (ART)...
  86. ncbi Development and validation of the Infertility Self-Efficacy scale
    Tara M Cousineau
    Inflexxion, Newton, Massachusetts 02464, USA
    Fertil Steril 85:1684-96. 2006
    To develop and validate a scale of perceived self-efficacy for people coping with infertility treatment.
  87. ncbi A longitudinal, prospective study on emotional adjustment before, during and after consecutive fertility treatment cycles
    C M Verhaak
    Department of Medical Psychology, Department of Obstetrics and Gynaecology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Hum Reprod 20:2253-60. 2005
    ..A longitudinal study into the course of the emotional response to IVF from pre-treatment to 6 months post-treatment and factors that contributed to that course...
  88. pmc Predictors of not pursuing infertility treatment after an infertility diagnosis: examination of a prospective U.S. cohort
    Michael L Eisenberg
    Department of Urology, University of California San Francisco, San Francisco, California 94143 0738, USA
    Fertil Steril 94:2369-71. 2010
    ..a prospective cohort of 434 couples in Northern California and found that 13% did not pursue any form of infertility treatment after their initial consultation...
  89. ncbi Professionals' perceptions of their patients' experiences with fertility care
    J W M Aarts
    Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    Hum Reprod 26:1119-27. 2011
    ..The objective of the present study was to determine to what extent gynaecologists, physicians specializing in infertility and nurses can estimate the level of patient-centredness of their clinic.
  90. ncbi Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion
    Reza Behjati
    Reproductive Biology, Biotechnology and Infertility Research Center, Avesina Research Institute, Tehran, Iran
    Ann Hematol 85:268-71. 2006
    ..II (FII) G20210A mutations are three important causes of thrombophilia, the condition that might be related to infertility and recurrent spontaneous abortion (RSA)...
  91. ncbi A prospective investigation into the reasons why insured United States patients drop out of in vitro fertilization treatment
    Alice D Domar
    Boston IVF, Beth Israel Deaconess Medical Center, Harvard Medical School, Waltham, Massachusetts 02451, USA
    Fertil Steril 94:1457-9. 2010
    ..To determine the primary reason why insured patients drop out of IVF treatment in the United States and to identify methods to decrease such behavior...
  92. ncbi Assisted reproductive technologies in Canada: 2005 results from the Canadian Assisted Reproductive Technologies Register
    Joanne Gunby
    Pegasus Technologies, Burlington, Ontario, Canada
    Fertil Steril 91:1721-30. 2009
    ..To present a report on assisted reproductive technologies (ART) cycles performed in 2005 in Canada. This is the fifth annual report from the Canadian ART Register (CARTR)...
  93. ncbi A multi-faceted strategy to improve the use of national fertility guidelines; a cluster-randomized controlled trial
    Selma M Mourad
    Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Reprod 26:817-26. 2011
    ..This study therefore contributes to an increased understanding of fertility guideline implementation in general, and the role of patients in particular...
  94. ncbi Reducing the incidence of twins from IVF treatments: predictive modelling from a retrospective cohort
    Stephen A Roberts
    Health Sciences Methodology, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, UK
    Hum Reprod 26:569-75. 2011
    ..We aimed to utilize a previously published data set and statistical model based on routinely collected clinical data to predict the outcomes of policies that increase the proportion of eSET...
  95. ncbi Gender differences and factors associated with treatment-seeking behaviour for infertility in Rwanda
    N Dhont
    International Centre for Reproductive Health, Ghent University, Ghent, Belgium
    Hum Reprod 25:2024-30. 2010
    This study examines perceptions of infertility causes, treatment-seeking behaviour and factors associated with seeking medical care in an urban infertile population in Rwanda, as well as the response of health providers.
  96. ncbi Prevalence and predictors of sexual problems, relationship stress, and depression in female partners of infertile couples
    Christian J Nelson
    Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York City, New York, USA
    J Sex Med 5:1907-14. 2008
    b>Infertility has been associated with anxiety, stress, and sexual problems in both men and women.
  97. ncbi Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients
    K Oktay
    Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hum Reprod Update 7:526-34. 2001
    ..With the addition of promising data from humans, ovarian tissue cryopreservation from selected patients before cancer treatment, and in those requiring oophorectomy for benign causes, is now advocated...
  98. ncbi The autoimmune bases of infertility and pregnancy loss
    Howard J A Carp
    Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer and Tel Aviv University, Tel Hashomer, Israel
    J Autoimmun 38:J266-74. 2012
    ..autoimmune mechanisms may influence the reproductive life and fertility of both sexes, commonly manifesting as infertility or pregnancy loss...
  99. ncbi Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin
    Susana B Rulli
    Department of Physiology, University of Turku, Finland
    Endocrinology 143:4084-95. 2002
    ..The TG females presented with precocious puberty, infertility, enhanced ovarian steroidogenesis, and abnormal uterine structure...
  100. ncbi The non-independence of treatment outcomes from repeat IVF cycles: estimates and consequences
    Stephen A Roberts
    Health Sciences Methodology, Manchester Academic Health Science Centre MAHSC, University of Manchester, Manchester M13 9WL, UK
    Hum Reprod 27:436-43. 2012
    ..However, there are few studies that have attempted to estimate the magnitude of these effects or their clinical consequences...

Research Grants73

  1. Physiology of Hypothalamic Neurosteroidal Progesterone
    Paul E Micevych; Fiscal Year: 2013
    ..hormone (LH) surge and ovulation which are important for both regulating fertility as well as treating infertility. Approximately 12% of women (7...
  2. Interdisciplinary Research Training in Reproduction for Indian Fellows
    John C Herr; Fiscal Year: 2010
    ..will be placed on training in cell and molecular biology of reproduction with translational components aimed at infertility and the discovery of new leads for contraceptives...
  3. Functional Analysis of the Dual Specificity Kinase NEK1 in Mammalian Meiosis
    JOANNA KIM HOLLOWAY; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Infertility affects about 15% of the reproductive population of the United States, with many of the underlying causes being ..
  4. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    ..Errors in gametogenesis have consequences that range from infertility to the transmission of chromosome abnormalities to the next generation...
  5. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..cachexia, and excessive exercise can all decrease gonadotropins secretion resulting in abnormal cyclicity and infertility. Obesity and diabetes can also negatively affect fertility...
  6. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    ..during in utero or early postnatal developmental periods, may cause ovarian dysfunction and female infertility in adulthood via epigenetic mechanisms (e.g., DNA methylation)...
  7. Transcriptional control of pituitary gonadotropin genes
    Varykina G Thackray; Fiscal Year: 2013
    ..expression in the gonadotrope is necessary for fertility and whether FoxO1 plays a role in obesity-related infertility. In Specific Aim 2, biochemical and tissue cell culture models will be used to characterize mechanisms of FoxO1 ..
  8. The role of novel, uncultivable bacteria in incident PID
    CATHERINE L contact HAGGERTY; Fiscal Year: 2011
    ..infection and inflammation of the female upper genital tract, often results in long-term sequelae, including infertility, chronic pelvic pain, ectopic pregnancy, and recurrent PID...
  9. Analysis of epigenetic regulation in early mammalian embryos via RNA interference
    Charles R Long; Fiscal Year: 2010
    ..Failed epigenetic programming is a primary suspect in the search for causes of unexplained infertility, congenital abnormalities and increased susceptibility to disease associated with both human assisted ..
  10. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ..Several recent clinical and laboratory studies documenting either subfertility or frank infertility in vitamin D3 deficient states suggest that vitamin D3 may be essential for normal reproductive physiology and ..
  11. Outcomes of Infertility Treatments in Clinic and Population-Based Cohorts
    Joseph B Stanford; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Infertility, defined as inability to conceive within one year of intercourse without contraception, is a common health condition for couples...
  12. GENETICS OF DELAYED PUBERTY
    Lawrence C Layman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Reproductive dysfunction manifested as infertility, early embryonic loss, or congenital anomalies afflicts 10- 15% of reproductive aged individuals and results in high economic and psychological ..
  13. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    ..to a better understanding the role of environmental toxins in paternal transmission of malformations and male infertility. If successful in completing these aims, we will have elucidated a novel major downstream effect of activation ..
  14. A Rapid Point-of-care Diagnostic for C.trachomitis STDs
    RICHARD F contact SELDEN; Fiscal Year: 2010
    ..trachomatis is an obligate intracellular pathogen of humans that causes blindness, pelvic inflammatory disease, infertility, and is an important cofactor in transmission of human immunodeficiency virus (HIV)...
  15. Cooperative Multicenter Reproductive Medicine Network (U10)
    MARCELLE IVONNE CEDARS; Fiscal Year: 2013
    ..Older infertility patients appear to have abnormal mitochondrial activity in oocytes and reduced production of ATP, which limits ..
  16. Simultaneous Insulin and Leptin Signaling in POMC Neurons Promotes Fertility and
    LATRICE DOREEN FAULKNER; Fiscal Year: 2013
    ..most frequent endocrine disorder seen in reproductive-aged women and is characterized by chronic anovulation, infertility, insulin resistance, and hyperandrogenism...
  17. Validation of Novel Infertility Biomarker
    PETER SUTOVSKY SUTOVSKY; Fiscal Year: 2012
    ..medicine, namely the lack of reliable, objective methodology for accurate diagnostics of human male infertility. Our goal is to validate the sperm-specific thioredoxin SPTRX3 as a novel biomarker of human sperm quality...
  18. Chromosomal Control of Segregation of C. Elegans
    Abby F Dernburg; Fiscal Year: 2013
    ..Errors in meiosis are a major cause of human miscarriages, infertility, and mental retardation arising from chromosomal birth defects such as Down syndrome...
  19. Klotho regulation and aging
    Gwendalyn D King; Fiscal Year: 2010
    ..atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  20. MRNA PROCESSING IN REPRODUCTION AND FERTILIZATION
    Clinton C MacDonald; Fiscal Year: 2013
    ..of DCstF-64, we will perform a genetic test to determine whether CstF-64 will complement the Cstf2ttm1Ccma infertility phenotype, purify DCstF-64 complexes to look for germ cell-specific components, and test functions of DCstF-64 ..
  21. Transposons in Female Reproductive Health and Disease
    Zev Williams; Fiscal Year: 2013
    ..the purpose of establishing a career as an NIH funded independent investigator in reproductive medicine and infertility. Dr...
  22. Progesterone's Role in Pubertal Maturation in Normal and Hyperandrogenemic Adoles
    JESSICAH S P COLLINS; Fiscal Year: 2011
    ..PCOS is associated with hirsutism, acne, irregular menstrual cycles and infertility and causes an increased risk for obesity, the metabolic syndrome, and type 2 diabetes mellitus...
  23. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility.
  24. New Investigation Initiatives for the Prevention of Complications of Thalassemia
    Ellis J Neufeld; Fiscal Year: 2011
    ..iron-related complications including heart failure, arrhythmia, cirrhosis, diabetes, as well as infertility and other reproductive endocrine disorders...
  25. Model of the Human Testis for Reproductive Toxicology
    PAUL JACOB TUREK; Fiscal Year: 2011
    ..toxins could help protect developing fetuses from unwanted toxic exposures, reduce the incidence of male infertility, potentially lower rates of testis cancer, and create safer drugs for the marketplace...
  26. Human Decidual Leukocytes and Their Placental Ligands
    JACK STROMINGER; Fiscal Year: 2009
    ..e. recurrent spontaneous abortion (RSA), some forms of infertility due to failure of implantation of the blastocyst, preeclampsia and fetal growth restriction due to the failure ..
  27. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ..anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP);(2) menstrual disorders;(3) infertility;(4) EPL and SAB;and (5) adverse birth outcomes? Aim 2...
  28. Experimental engineering of ovarian grafting to promote angiogenesis for fertilit
    GLENN LEWIS SCHATTMAN; Fiscal Year: 2010
    ..Women have had fewer options for avoiding iatrogenic infertility and menopause compared with men, and prepubertal girls have virtually none...
  29. Calcium Signaling in the Pubertal Activation of the GnRH Pulse Generator
    Daniel J Spergel; Fiscal Year: 2011
    ..The knowledge obtained may aid in developing new leads for contraception, as well as treatments for infertility and the pubertal disorders polycystic ovary syndrome, hypogonadism, precocious puberty, and delayed puberty, ..
  30. Enzymology of Chlamydia Pathogenesis
    Dewey G McCafferty; Fiscal Year: 2013
    ..cause numerous disease-related complications including pelvic inflammatory disease, ectopic pregnancy, infertility, and blindness...
  31. AAA ATPases linking mitochondria with microtubule processing in flies and yeast
    Karen G Hales; Fiscal Year: 2012
    ..further gene families that may ultimately be associated with human mitochondrial neuropathies, myopathies, and infertility syndromes...
  32. Molecular Analysis of GnRH Action
    Mark S Roberson; Fiscal Year: 2012
    ..Alternatively, a significant number of couples in the US and other developed countries confront issues of infertility. The impact of infertility and unintended pregnancy-related health and social issues strains US health care ..
  33. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility among women, and women with PCOS are at increased risk for pregnancy complications such as gestational diabetes and pre-eclampsia...
  34. A Novel Target for the Treatment of Endometriosis
    Paul D Crowe; Fiscal Year: 2011
    ..by applicant): Endometriosis is a major cause of severe pelvic pain, pain during menstruation, dyspareunia and infertility in women of child-bearing age with an estimated $22 billion cost of diagnosis and treatment in the U.S...
  35. Transcriptional Networks Regulating Luminal Environment in the Epididymis
    Ann Harris; Fiscal Year: 2013
    ..a small conductance, cAMP activated chloride ion channel, leads to developmental defects that cause male infertility in humans...
  36. ANALYSIS OF MEIOTIC CHROMOSOME SYNAPSIS IN YEAST
    Nancy M Hollingsworth; Fiscal Year: 2013
    ..In humans, failures in meiosis result in infertility and birth defects such as Trisomy 21 or Down Syndrome...
  37. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ..generated FKBP52-deficient mice, which are viable at birth and apparently normal into adulthood (except for infertility). Yet, cells derived from FKBP52 KO mice have reduced GR activity...
  38. The Role of Cks Proteins in Mammalian Meiosis
    Charles H Spruck; Fiscal Year: 2010
    ..regarding how meiosis is regulated at the molecular level and how dysregulation of this process leads to human infertility. The metaphase-to- anaphase transition of Ml is particularly relevant clinically because its dysregulation is ..
  39. An internet based prospective study of time to pregnancy
    Elizabeth E Hatch; Fiscal Year: 2013
    ..About 10-15 per cent of couples suffer from infertility, and the prevalence may be increasing...
  40. Response of Rhesus Sperm to Freezing: Recovery from Osmotic and Oxidative Stress
    Stuart A Meyers; Fiscal Year: 2010
    ..NHPs), especially genetically unique macaques, are important models of human disease with applications to infertility and contraception, infectious diseases and vaccine development, drug and alcohol addiction, neurological ..
  41. PTIP as an epigenetic regulator in male meiosis
    Guo Zhang Zhu; Fiscal Year: 2013
    ..Furthermore, collected information may offer insights into unexplained (or idiopathic) infertility in men and may lead to new strategies for male contraception and assisted reproduction.
  42. ALCOHOL AND HYPERPROLACTINEMIA
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    ..is known to be one of the major reasons for reproductive dysfunction such as amenorrhea, galactorrhea and infertility in women...
  43. North Carolina Birth Defects Study To Evaluate Pregnancy Exposures (NC BD-STEPS)
    Andrew Olshan; Fiscal Year: 2013
    ..targeted online modules related to early pregnancy exposures such as diet, obesity, physical activity, infertility, occupation and chronic medical conditions;(3) Develop innovative study questions and proposals using BD-STEPS ..
  44. Klotho regulation and aging
    GWENDALYN DIANN KING; Fiscal Year: 2013
    ..atherosclerosis, ectopic calcification, emphysema, osteoporosis, skin atrophy and hair loss, thymic involution, infertility and decreased bone mineral density)...
  45. CELL CYCLE CONTROL IN EARLY DROSOPHILA DEVELOPMENT
    Terry L Orr-Weaver; Fiscal Year: 2013
    ..Thus these studies will provide fundamental insights into regulatory defects leading to birth defects, infertility and cancer...
  46. Meiosis, SUMOylation and the ZIP3 Protein: Parallel Studies in Mouse and Yeast.
    Neil Hunter; Fiscal Year: 2012
    ..Relevance: Defects in recombination and post-translational modification have been linked to human infertility, miscarriage and genetic diseases, particularly cancer...
  47. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..Systematic and detailed characterizations of such events are necessary for advancing infertility treatments and developing novel, non-hormonal forms of contraception...
  48. Adverse Outcomes of Assisted Reproductive Technologies: Genetics or Epigenetics?
    Margareta Pisarska; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Infertility affects about 6.1 million people in the U.S., equivalent to 10% of the reproductive age population...
  49. Environmental Endocrine Disruptors and Human Sperm Chromosomal Abnormalities
    Melissa Perry; Fiscal Year: 2012
    ..About 40 percent of cases of human infertility are due to male factors...
  50. The evolutionary and molecular mechanisms underlying sperm performance in an emer
    Heidi S Fisher; Fiscal Year: 2013
    ..and physiological processes underlying mammalian reproduction and have served as models for studies of human infertility. Traditional strains of laboratory mice, however, are limited in the degree of variation in reproductive traits ..
  51. Mechanics and regulation of chromosome dynamics in meiotic prophase
    MICHAEL EDWARD DRESSER; Fiscal Year: 2012
    ..Inheritance of incorrect numbers of chromosomes or parts of chromosomes is a significant source of human infertility, morbidity and mortality resulting from genetic disease...
  52. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2013
    ..The phenotypes of our genetic models range from neonatal lethality to infertility to cancer...
  53. WNT and gonadotropin mediated regulation of ovarian steroidogenesis
    JENNIFER HERNANDEZ GIFFORD; Fiscal Year: 2010
    ..our knowledge about hormonal regulation of folliculogenesis and could improve treatments for female factor infertility and ovarian pathologies...
  54. MOLECULAR GENETIC ANALYSIS OF CHLAMYDIA PATHOGENICITY
    Anthony T Maurelli; Fiscal Year: 2012
    ..wide range of sexually transmitted diseases including cervicitis, salpingitis, pelvic inflammatory disease, and infertility in females and non-gonococcal arthritis and acute epididymitis in males...
  55. Oocyte-derived R-spondin2 as a Follicle Stimulating Hormone
    AARON JW HSUEH; Fiscal Year: 2013
    ..Although FSH has been used extensively for the treatment of female infertility, a sub-population of patients showed low FSH responses and has no alternative therapeutic options...
  56. Integration of PR and FoxO Signaling in Pituitary Gonadotropes
    Varykina G Thackray; Fiscal Year: 2010
    ..to new directions in treating a range of physiological disorders that can result from malfunction in gonadotropin production such as amenorrhea, precocious puberty, ideopathic hypogonadism, polycystic ovarian syndrome and infertility.
  57. Germ cell specifications and differentiation in planarians.
    Phillip A Newmark; Fiscal Year: 2013
    ..the mechanisms by which germ cells develop will help illuminate the nature of totipotency, the causes of infertility, and the origins of germ cell tumors...
  58. The influence of negative regulators of inflammation on C. trachomatis infections
    DAVID MARCELO OJCIUS; Fiscal Year: 2010
    ..is also responsible for pelvic inflammatory disease and scarring of fallopian tubes that can lead to infertility, ectopic pregnancy and chronic pelvic pain...
  59. The Kiss1 system in the neuroendocrine control of reproduction
    VICTOR MANUEL NAVARRO; Fiscal Year: 2013
    ..humans and rodents bearing inactivating mutations in this gene or its receptor (Kiss1r) exhibit impuberism and infertility. The objective of this proposal is to use genetic mouse models in combination with viral-dependent gene therapy ..
  60. Mouse model for eyelid disease: Congenital blepharophimosis
    Chia Yang Liu; Fiscal Year: 2013
    ..blepharophimosis, ptosis, epicanthus inversus, and telecanthus plus premature ovarian failure (POF), leading to infertility in woman. Type II consists of only the eyelid malformations without gender preference...
  61. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
    ..Accomplishment of these goals will lead to novel insights in clinical diagnosis of male infertility and provide tools for evaluating pharmacological contraceptive targets.
  62. Catenins: A role in spertmatogenesis and sperm maturation
    MANJEET KUMAR RAO; Fiscal Year: 2010
    ..male fertility and a better understanding of the mechanisms by which defects in these critical pathways lead to infertility. In addition, these studies could lead to new insights for therapeutically compromising germ cell movement in ..
  63. Cisplatin and Mechanisms of Long-term Male Infertility
    JOHN RICHBURG; Fiscal Year: 2007
    ..historically believed that loss of stem spermatogonia during chemotherapeutic treatment accounts for long-term infertility and/or delayed recovery of spermatogenesis...
  64. Role of mineralocorticoid receptor in primate ovarian function
    CHARLES CHAFFIN; Fiscal Year: 2009
    ..The formation, function, and demise of the primate corpus luteum are critical aspects of menstrual cyclicity, infertility, and contraceptive intervention...
  65. INCREASED TESTICULAR CD2+ & INFERTILITY WITH VARICOCELE
    Susan Benoff; Fiscal Year: 2004
    DESCRIPTION: Varicocele-associated human male infertility (VAI) represents greater then 20 percent of male infertility in the US. Surgical repair of varicocele restores fertility only 1/3 of time...
  66. BIOCHEMICAL MARKERS OF SPERM FERTILITY
    Gabor Huszar; Fiscal Year: 1999
    he central theme of our research is idiopathic or unexplained male infertility which affects about 1.5 million American men. For the present proposal we have identified a fertIle control population...
  67. REGULATION OF ENDOMETRIAL PROSTAGLANDIN F-2A SECRETION
    MARK MIRANDO; Fiscal Year: 1999
    b>Infertility is a medical problem of major importance int he United States. A major portion of infertility in humans is due to embryonic and fetal wastage which occurs in at least 70-80% of all conceptions...
  68. MALE INFERTILITY: SPERM MOTILITY AND AXONEMAL STABILITY
    REGINA TURNER; Fiscal Year: 2001
    ..of the Department of Obstetrics and Gynecology to apply basic research in reproductive biology to human infertility. Dr...
  69. CONVENTIONAL INFERTILITY THERAPY VS FAST TRACK TO IVF
    Richard Reindollar; Fiscal Year: 2004
    This study is designed to determine the cost-effectiveness of a fast track to in vitro fertilization (IVF) infertility therapy by conducting a randomized prospective clinical trial to compare its success rates and costs to that of ..
  70. MECHANISMS OF INFERTILITY IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2002
    The long-range objective is to develop a clinically useful primate model for endometriosis-associated infertility in order to define underlying molecular biological and physiologic mechanisms and to test the efficacy of experimental ..
  71. PERITONEAL MACROPHAGE MIGRATION IN ENDOMETRIOSIS
    CECIL LYTTLE; Fiscal Year: 1993
    ..of this research is to advance our understanding of the occurrence of endometriosis and the associated infertility. The research will focus on the cause of the infertility associated with this disease...
  72. ANALYSIS OF THE ROLE OF GCNF IN SPERMATOGENESIS
    Austin Cooney; Fiscal Year: 1999
    Male idiopathic sterility is the form of male infertility about which least is known because it is due to multiple causes. Generally, affected males display gross or subtle abnormalities in sperm function...
  73. CENTROSOME DEFECTS AS CAUSES OF MALE INFERTILITY
    Gerald Schatten; Fiscal Year: 1999
    ..investigates the microtubule organizing capacity of the human sperm centrosome as causes of idiopathic male infertility . Eighteen questions are posed in four specific aims using sperm from fertile and infertile men...