dental caries

Summary

Summary: Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp. The three most prominent theories used to explain the etiology of the disease are that acids produced by bacteria lead to decalcification; that micro-organisms destroy the enamel protein; or that keratolytic micro-organisms produce chelates that lead to decalcification.

Top Publications

  1. ncbi Tuftelin, mutans streptococci, and dental caries susceptibility
    R L Slayton
    Department of Pediatric Dentistry, University of Washington School of Dentistry, Box 357136, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Dent Res 84:711-4. 2005
  2. pmc Bacteria of dental caries in primary and permanent teeth in children and young adults
    Jørn A Aas
    Institute of Oral Biology, University of Oslo, Post Box 1052 Blindern, 0316 Oslo, Norway
    J Clin Microbiol 46:1407-17. 2008
  3. ncbi Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencing
    Zongxin Ling
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
    Microb Ecol 60:677-90. 2010
  4. ncbi The role of bacteria in the caries process: ecological perspectives
    N Takahashi
    Division of Oral Ecology and Biochemistry, Department of Oral Biology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    J Dent Res 90:294-303. 2011
  5. ncbi Dental caries
    Robert H Selwitz
    College of Dentistry, Department of Community Dentistry and Behavioral Science, University of Florida, FL, USA
    Lancet 369:51-9. 2007
  6. ncbi The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries
    A I Ismail
    Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1978, USA
    Community Dent Oral Epidemiol 35:170-8. 2007
  7. pmc Bacterial 16S sequence analysis of severe caries in young permanent teeth
    Erin L Gross
    Division of Oral Biology, The Ohio State University, College of Dentistry, Columbus, Ohio 43210, USA
    J Clin Microbiol 48:4121-8. 2010
  8. ncbi Effective use of fluorides for the prevention of dental caries in the 21st century: the WHO approach
    Poul Erik Petersen
    Oral Health Programme, World Health Organization, Geneva, Switzerland
    Community Dent Oral Epidemiol 32:319-21. 2004
  9. pmc Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis
    Erin L Gross
    Division of Oral Biology, College of Dentistry, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e47722. 2012
  10. ncbi Pro-inflammatory cytokines in saliva of adolescents with dental caries disease
    Agnieszka Gornowicz
    Department of Biotechnology, Medical University, Bialystok, Poland
    Ann Agric Environ Med 19:711-6. 2012

Detail Information

Publications315 found, 100 shown here

  1. ncbi Tuftelin, mutans streptococci, and dental caries susceptibility
    R L Slayton
    Department of Pediatric Dentistry, University of Washington School of Dentistry, Box 357136, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Dent Res 84:711-4. 2005
    The purpose of this study was to identify genetic factors that contribute to dental caries susceptibility, either alone or in combination with environmental factors...
  2. pmc Bacteria of dental caries in primary and permanent teeth in children and young adults
    Jørn A Aas
    Institute of Oral Biology, University of Oslo, Post Box 1052 Blindern, 0316 Oslo, Norway
    J Clin Microbiol 46:1407-17. 2008
    Although Streptococcus mutans has been implicated as a major etiological agent of dental caries, our cross-sectional preliminary study indicated that 10% of subjects with rampant caries in permanent teeth do not have detectable levels of ..
  3. ncbi Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencing
    Zongxin Ling
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
    Microb Ecol 60:677-90. 2010
    Oral microbiota plays a vital role in maintaining the homeostasis of oral cavity. Dental caries are among the most common oral diseases in children and pathogenic bacteria contribute to the development of the disease...
  4. ncbi The role of bacteria in the caries process: ecological perspectives
    N Takahashi
    Division of Oral Ecology and Biochemistry, Department of Oral Biology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    J Dent Res 90:294-303. 2011
    ..the demineralization/remineralization balance toward net mineral loss, leading to initiation/progression of dental caries (acidogenic stage)...
  5. ncbi Dental caries
    Robert H Selwitz
    College of Dentistry, Department of Community Dentistry and Behavioral Science, University of Florida, FL, USA
    Lancet 369:51-9. 2007
    b>Dental caries, otherwise known as tooth decay, is one of the most prevalent chronic diseases of people worldwide; individuals are susceptible to this disease throughout their lifetime...
  6. ncbi The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries
    A I Ismail
    Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1978, USA
    Community Dent Oral Epidemiol 35:170-8. 2007
    ..found to have discriminatory validity in analyses of social, behavioral and dietary factors associated with dental caries. The reliability of six examiners to classify tooth surfaces by their ICDAS carious status ranged between good ..
  7. pmc Bacterial 16S sequence analysis of severe caries in young permanent teeth
    Erin L Gross
    Division of Oral Biology, The Ohio State University, College of Dentistry, Columbus, Ohio 43210, USA
    J Clin Microbiol 48:4121-8. 2010
    ....
  8. ncbi Effective use of fluorides for the prevention of dental caries in the 21st century: the WHO approach
    Poul Erik Petersen
    Oral Health Programme, World Health Organization, Geneva, Switzerland
    Community Dent Oral Epidemiol 32:319-21. 2004
    ..According to the World Oral Health Report 2003, dental caries remains a major public health problem in most industrialized countries, affecting 60-90% of schoolchildren and ..
  9. pmc Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis
    Erin L Gross
    Division of Oral Biology, College of Dentistry, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e47722. 2012
    b>Dental caries in very young children may be severe, result in serious infection, and require general anesthesia for treatment...
  10. ncbi Pro-inflammatory cytokines in saliva of adolescents with dental caries disease
    Agnieszka Gornowicz
    Department of Biotechnology, Medical University, Bialystok, Poland
    Ann Agric Environ Med 19:711-6. 2012
    b>Dental caries is an inflammatory disease with multifactorial etiology...
  11. ncbi Dental caries affects body weight, growth and quality of life in pre-school children
    A Sheiham
    Department of Epidemiology and Public Health, University College London, 1 19 Torrington Place, London, WC1E 6BT
    Br Dent J 201:625-6. 2006
    The effect of a relatively common chronic disease, severe dental caries, affects young childrens' growth and well-being...
  12. pmc Quantitative analysis of diverse Lactobacillus species present in advanced dental caries
    Roy Byun
    Institute of Dental Research, Westmead Centre for Oral Health, P O Box 533, Wentworthville, NSW 2145, Australia
    J Clin Microbiol 42:3128-36. 2004
    Our previous analysis of 65 advanced dental caries lesions by traditional culture techniques indicated that lactobacilli were numerous in the advancing front of the progressive lesion...
  13. ncbi The global increase in dental caries. A pending public health crisis
    Robert A Bagramian
    School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Am J Dent 22:3-8. 2009
    ..data from many countries clearly indicates that there is a marked increase in the prevalence of dental caries. This global increase in dental caries prevalence affects children as well as adults, primary as well as ..
  14. ncbi Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans
    Keisuke Ito
    Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Mol Biol 408:177-86. 2011
    Glucansucrase (GSase) from Streptococcus mutans is an essential agent in dental caries pathogenesis. Here, we report the crystal structure of S...
  15. ncbi Exploring the association of dental caries with social factors and nutritional status in Brazilian preschool children
    Luciana B Oliveira
    Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Universidade de Sao Paulo, Sao Paulo, Brazil
    Eur J Oral Sci 116:37-43. 2008
    The main objective of this study was to assess whether dental caries status was related to nutritional status in preschool urban Brazilian children aged 12-59 months...
  16. ncbi Influence of family structure on dental caries experience of preschool children in Sri Lanka
    N Wellappuli
    Ministry of Health, Colombo, Sri Lanka
    Caries Res 46:208-12. 2012
    The prevalence of dental caries in preschool children has not been declining in the recent past. A growing body of research suggests that social and behavioural factors may play a considerable role in the aetiology of dental caries.
  17. ncbi Use of fluorides in dental caries management
    C H Chu
    Faculty of Dentistry, University of Hong Kong, China
    Gen Dent 58:37-43; quiz 44-5, 79-80. 2010
    ..Fluorosis has been reported in conjunction with increased doses of fluoride. A coordinated approach to fluoride delivery is essential to avoid the risk of fluorosis...
  18. ncbi Alkali production by oral bacteria and protection against dental caries
    R A Burne
    Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Box 611, 601 Elmwood Ave, Rochester, NY 14642, USA
    FEMS Microbiol Lett 193:1-6. 2000
    ..and urea, plays major roles in pH homeostasis in oral biofilms and may moderate initiation and progression of dental caries. This short review highlights recent progress on understanding molecular genetic and physiologic aspects of ..
  19. ncbi Efficacy of silver diamine fluoride for Arresting Caries Treatment
    R Yee
    Department of Global Oral Health, Radboud University Nijmegen Medical Centre, College of Dental Sciences, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Dent Res 88:644-7. 2009
    Arresting Caries Treatment (ACT) has been proposed to manage untreated dental caries in children...
  20. ncbi Dental caries experience and its relationship to social and behavioural factors among 3-5-year-old children in Uganda
    S N Kiwanuka
    Centre for International Health, University of Bergen, Bergen, Norway
    Int J Paediatr Dent 14:336-46. 2004
    ..The aim of this study was to assess the socio-demographic and behavioural correlates of caries experience and sugar intake patterns among pre-school children in Uganda...
  21. ncbi Validation of the Child Perceptions Questionnaire (CPQ 11-14)
    L A Foster Page
    Department of Oral Sciences, School of Dentistry, University of Otago, PO Box 647, Dunedin, New Zealand
    J Dent Res 84:649-52. 2005
    ..Children (N = 430) completed the CPQ(11-14) and were examined for malocclusion (Dental Aesthetic Index) and dental caries. There was a distinct gradient in mean CPQ(11-14) scores by malocclusion severity, but there were differences ..
  22. ncbi Disparities in oral health and access to care: findings of national surveys
    Burton L Edelstein
    Children s Dental Health Project, Washington, DC 20036, USA
    Ambul Pediatr 2:141-7. 2002
    ..Because tooth decay, or dental caries, remains the preeminent oral disease of childhood and national data is available on dental office visits, ..
  23. ncbi The microbiology of primary dental caries in humans
    J M Tanzer
    School of Dental Medicine, University of Connecticut, Farmington 06030 1605, USA
    J Dent Educ 65:1028-37. 2001
    ..review from 1966 to 2000 revealed 2,730 English-language publications on the role of bacteria in human primary dental caries in vivo. The most pertinent 313 papers were analyzed in evidence tables accessible online (http://www.nidcr...
  24. ncbi Long-term effectiveness of a nutritional program in reducing early childhood caries: a randomized trial
    Carlos Alberto Feldens
    Department of Pediatric Dentistry, Universidade Luterana do Brasil, Canoas, Brazil
    Community Dent Oral Epidemiol 38:324-32. 2010
    ..To investigate the effectiveness of home visits advising mothers about healthy feeding practices during the first year of life on the occurrence of early childhood caries and severe early childhood caries at 4 years of age...
  25. pmc Trends in oral health by poverty status as measured by Healthy People 2010 objectives
    Bruce A Dye
    Centers for Disease Control and Prevention, National Center for Health Statistics, 3311 Toledo Rd, Room 4416, Hyattsville, MD 20782, USA
    Public Health Rep 125:817-30. 2010
    ..Poverty is a significant social determinant for oral health, yet Healthy People 2010 (HP 2010) does not monitor changes in oral health status by poverty. We assessed recent trends for six HP 2010 oral health objectives by poverty status...
  26. pmc Dental caries status of Dai preschool children in Yunnan Province, China
    Shinan Zhang
    Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China
    BMC Oral Health 13:68. 2013
    ..This study aimed to describe the oral health status of Dai preschool children in China and the factors that influence their oral health status...
  27. ncbi MMP13 polymorphism decreases risk for dental caries
    P N Tannure
    Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Rio de Janeiro, Brazil
    Caries Res 46:401-7. 2012
    ..Genetic variations in MMP13 may contribute to individual differences in caries susceptibility. Our findings reinforce that susceptibility to caries results from gene-environment interactions...
  28. ncbi National pathfinder survey on children's oral health in Italy: pattern and severity of caries disease in 4-year-olds
    G Campus
    Dental Institute, University of Sassari, Sassari, Italy
    Caries Res 43:155-62. 2009
    ..22. The results suggest a need to plan preventive programs to reduce oral health disparities among Italian preschool children, based on educational intervention with parents and children concerning oral health and caries prevention...
  29. ncbi Beyond the dmft: the human and economic cost of early childhood caries
    Paul S Casamassimo
    Department of Dentistry, Nationwide Children s Hospital, 700 Children s Drive, Columbus, Ohio 43205, USA
    J Am Dent Assoc 140:650-7. 2009
    ..This report describes morbidity and mortality associated with ECC and its treatment...
  30. ncbi The impact of dental caries and trauma in children on family quality of life
    Jenny Abanto
    Department of Pediatric Dentistry and Orthodontics, Dental School, University of Sao Paulo USP, Sao Paulo, SP, Brazil
    Community Dent Oral Epidemiol 40:323-31. 2012
    To assess the impact of children's dental caries (DC) and traumatic dental injuries (TDI) on parents' quality of life (QoL), adjusted by family income.
  31. ncbi Environmental, maternal, and child factors which contribute to early childhood caries: a unifying conceptual model
    W Kim Seow
    Centre for Paediatric Dentistry, School of Dentistry, University of Queensland, Brisbane, Queensland, Australia
    Int J Paediatr Dent 22:157-68. 2012
    ..The aim of this paper is to propose a unifying conceptual model that ties together the broad social environmental, maternal, and child factors that are commonly associated with ECC...
  32. pmc Nanotechnology-based restorative materials for dental caries management
    Mary A S Melo
    Biomaterials and Tissue Engineering Division, Dept of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA
    Trends Biotechnol 31:459-67. 2013
    ..applications of functional nanoparticles incorporated in dental restorative materials as useful strategies to dental caries management. We also overview proposed antimicrobial and remineralizing mechanisms...
  33. pmc Dental caries experience, oral health status and treatment needs of dental patients with autism
    Mohamed Abdullah Jaber
    Dental School, Ajman University of Science and Technology, Al Jurf campus, Ajman, United Arab Emirates
    J Appl Oral Sci 19:212-7. 2011
    ....
  34. ncbi Changes in parent-assessed oral health-related quality of life among young children following dental treatment under general anaesthetic
    P E Malden
    Capital and Coast District Health Board, Wellington, New Zealand
    Community Dent Oral Epidemiol 36:108-17. 2008
    ....
  35. pmc GWAS of dental caries patterns in the permanent dentition
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 92:38-44. 2013
    The importance of susceptibility genes in the risk for dental caries has been clearly established...
  36. ncbi Metabolic syndrome, periodontal infection, and dental caries
    P Timonen
    Institute of Dentistry, University of Oulu, PO Box 5281, 90014 Oulu, Finland
    J Dent Res 89:1068-73. 2010
    Only a few studies have examined the association of metabolic syndrome with periodontal infection and dental caries. The aim in this study was to examine the association of metabolic syndrome with periodontal infection and dental caries ..
  37. ncbi [Experience, prevalence and severity of dental caries and its association with nutritional status in Mexican infants 17-47 months]
    Ana Gabriela Zúñiga-Manríquez
    Area Académica de Odontología, Instituto de Ciencias de la Salud, Universidad Autonoma del Estado de Hidalgo
    Rev Invest Clin 65:228-36. 2013
    To determine the experience, prevalence and severity of dental caries and its relationship with nutritional status in nursery infants 17 to 47 months of age.
  38. pmc Genome-wide association scan for childhood caries implicates novel genes
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 90:1457-62. 2011
    b>Dental caries is the most common chronic disease in children and a major public health concern due to its increasing incidence, serious health and social co-morbidities, and socio-demographic disparities in disease burden...
  39. pmc Untreated severe dental decay: a neglected determinant of low Body Mass Index in 12-year-old Filipino children
    Habib Benzian
    Fit for School Inc, Salcedo Village, Makati City, Manila, Philippines
    BMC Public Health 11:558. 2011
    ..Elementary school children suffer from high prevalence of stunting and underweight.The present study aimed to investigate the association between untreated dental decay and Body Mass Index (BMI) among 12-year-old Filipino children...
  40. ncbi Effect of a school-based oral health education programme in Wuhan City, Peoples Republic of China
    Poul Erik Petersen
    World Health Organisation, 20 Avenue Appia, CH 1221 Geneva 27, Switzerland
    Int Dent J 54:33-41. 2004
    ..To assess oral health outcomes of a school-based oral health education (OHE) programme on children, mothers and schoolteachers in China, and to evaluate the methods applied and materials used...
  41. ncbi The microbiological profiles of saliva, supragingival and subgingival plaque and dental caries in adults with and without type 2 diabetes mellitus
    J Hintao
    Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Thailand
    Oral Microbiol Immunol 22:175-81. 2007
    ..The relationships between suspected bacteria in saliva, yeasts in oral rinse, and supragingival and subgingival plaque versus root surface and coronal caries in adults with type 2 diabetes mellitus and a non-diabetic group were explored...
  42. ncbi Association between level of education and oral health status in 35-, 50-, 65- and 75-year-olds
    J Paulander
    Department of Periodontology, Faculty of Odontology, The Sahlgrenska Academy of Göteborg University, Sweden
    J Clin Periodontol 30:697-704. 2003
    ..The aim of the present study was to evaluate the association between educational level and dental disease, treatment needs and oral hygiene habits...
  43. ncbi Caries in populations--a theoretical, causal approach
    D Holst
    Community Dentistry, Dental Faculty University of Oslo, Norway
    Eur J Oral Sci 109:143-8. 2001
    ..The image proposed in this paper is intended to spur discussion about important aspects of the epidemiology of caries in populations...
  44. ncbi Clinical applications and outcomes of using indicators of risk in caries management
    D Zero
    Department of Preventive and Community Dentistry, Indiana University School of Dentistry, USA
    J Dent Educ 65:1126-32. 2001
    ..In many instances, the use of a single predictor gave equally good results as the use of a combination of predictors. Previous caries experience was an important predictor for all tooth types...
  45. ncbi Sugars and dental caries
    Riva Touger-Decker
    University of Medicine and Dentistry of New Jersey, School of Health Related Professions, New Jersey Dental School, Newark 07107, USA
    Am J Clin Nutr 78:881S-892S. 2003
    ..Studies have confirmed the direct relation between intake of dietary sugars and dental caries across the life span...
  46. pmc Cultivable anaerobic microbiota of severe early childhood caries
    A C R Tanner
    Department of Molecular Genetics, The Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA
    J Clin Microbiol 49:1464-74. 2011
    ..The major caries-associated species were S. mutans and S. wiggsiae, the latter of which is a candidate as a newly recognized caries pathogen...
  47. ncbi Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis--United States, 1988-1994 and 1999-2002
    Eugenio D Beltran-Aguilar
    Division of Oral Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, USA
    MMWR Surveill Summ 54:1-43. 2005
    b>Dental caries is a common chronic disease that causes pain and disability across all age groups. If left untreated, dental caries can lead to pain and infection, tooth loss, and edentulism (total tooth loss)...
  48. ncbi A mixed-bacteria ecological approach to understanding the role of the oral bacteria in dental caries causation: an alternative to Streptococcus mutans and the specific-plaque hypothesis
    I Kleinberg
    Department of Oral Biology and Pathology, State University of New York, Stony Brook, New York 11794 8702, USA
    Crit Rev Oral Biol Med 13:108-25. 2002
    For more than 100 years, investigators have tried to identify the bacteria responsible for dental caries formation and to determine whether their role is one of specificity...
  49. ncbi The complex oral microflora of high-risk individuals and groups and its role in the caries process
    David Beighton
    Department of Microbiology, Dental Institute, King s College London, London, UK
    Community Dent Oral Epidemiol 33:248-55. 2005
    ..A combination of conventional and molecular approaches are required to elucidate the involvement of an individual taxon and of microbial populations with particular traits in the caries process...
  50. ncbi Dental caries in 0- to 5-year-old Brazilian children: prevalence, severity, and associated factors
    Simone Helena Ferreira
    Department of Paediatric Dentistry, Lutheran University of Brazil, Canoas, Brazil
    Int J Paediatr Dent 17:289-96. 2007
    This cross-sectional study investigated the prevalence and severity of dental caries and their association with demographic and socio-economic variables in Brazilian preschoolers.
  51. ncbi PUFA--an index of clinical consequences of untreated dental caries
    B Monse
    Department of Education, Health and Nutrition Centre, City Division, Cagayan de Oro, Philippines
    Community Dent Oral Epidemiol 38:77-82. 2010
    b>Dental caries is a global public health problem, especially in children. Most caries in developing countries remains untreated...
  52. ncbi Changes in dental caries 1953-2003
    T M Marthaler
    Center for Dentistry, University of Zurich, Zurich, Switzerland
    Caries Res 38:173-81. 2004
    ..For this and other reasons, caries epidemiology will remain an indispensable part of dental public health...
  53. pmc Microbial risk markers for childhood caries in pediatricians' offices
    E Kanasi
    Department of Molecular Genetics, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA
    J Dent Res 89:378-83. 2010
    b>Dental caries in pre-school children has significant public health and health disparity implications...
  54. ncbi A DNA vaccine encoding a cell-surface protein antigen of Streptococcus mutans protects gnotobiotic rats from caries
    M W Fan
    School of Stomatology, Wuhan University, People s Republic of China
    J Dent Res 81:784-7. 2002
    ..Thus, inhibiting PAc is predicted to provide protection against caries. To develop vaccines against dental caries, we constructed a DNA vaccine, pCIA-P, which encodes two high-conservative regions of PAc...
  55. ncbi Factors associated with dental admissions for children aged under 5 years in Western Australia
    L Slack-Smith
    School of Population Health, The University of Western Australia, Crawley, Western Australia, Australia
    Arch Dis Child 94:517-23. 2009
    ..There is limited literature describing dental admissions in preschool children. This paper describes dental hospital admissions and associated factors in children aged under 5 years...
  56. ncbi Case definition, aetiology and risk assessment of early childhood caries (ECC): a revisited review
    G Vadiakas
    Dept of Paediatric Dentistry, Dental School, University of Athens, Greece
    Eur Arch Paediatr Dent 9:114-25. 2008
    ..To provide a review of the existing literature on early childhood caries (ECC) with particular reference on the nomenclature, case definition, epidemiology, etiology and risk assessment...
  57. ncbi Sensitivity and responsiveness of the Chinese ECOHIS to dental treatment under general anaesthesia
    Gillian H M Lee
    Paediatric Dentistry, University of Hong Kong, Hong Kong SAR, China
    Community Dent Oral Epidemiol 39:372-7. 2011
    ..This study aimed to investigate the sensitivity and responsiveness of the Chinese version of the Early Childhood Oral Health Impact Scale (ECOHIS) to dental treatment under general anaesthesia (GA)...
  58. pmc Molecular analysis of bacterial species associated with childhood caries
    Mitzi R Becker
    Department of Pediatric Dentistry, College of Dentistry, The Ohio State University, Columbus, Ohio 43218 2357, USA
    J Clin Microbiol 40:1001-9. 2002
    ..identification and enumeration now make it possible to more precisely study the microbiota associated with dental caries. The purpose of this study was to compare the bacteria found in early childhood caries (ECC) to those found in ..
  59. pmc Global oral health inequalities: dental caries task group--research agenda
    N Pitts
    IADR Cariology Group and Evidence based Dentistry Network, European Organisation for Caries Research, International Caries Detection and Assessment System, European Association for Dental Public Health, Centre for Clinical Innovations, University of Dundee, Scotland, UK
    Adv Dent Res 23:211-20. 2011
    The IADR Global Oral Health Inequalities Task Group on Dental Caries has synthesized current evidence and opinion to identify a five-year implementation and research agenda which should lead to improvements in global oral health, with ..
  60. ncbi Dental caries and its association with sociodemographics, erosion, and diet in schoolchildren from southeast Brazil
    Sheyla Marcia Auad
    Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Pediatr Dent 31:229-35. 2009
    ....
  61. pmc Microbial risk indicators of early childhood caries
    P M Corby
    University of Pittsburgh, School of Dental Medicine, Division of Pediatric and Developmental Dental Sciences, 3501 Terrace St, Room 386, Pittsburgh, PA 15261, USA
    J Clin Microbiol 43:5753-9. 2005
    ..sequence and reverse-capture checkerboard hybridization, for identification of the bacteria associated with dental caries and with dental health in a subset of 204 twins aged 1.5 to 7 years old...
  62. ncbi Prevalence and severity of dental caries among American Indian and Alaska Native preschool children
    KATHY R PHIPPS
    Oral Health Surveillance Consultant, Morro Bay, CA 93442, USA
    J Public Health Dent 72:208-15. 2012
    ..To describe the Indian Health Service (IHS) oral health surveillance system and the oral health status of American Indian and Alaska Native (AI/AN) children aged 1-5 years...
  63. ncbi Association between AMELX polymorphisms and dental caries in Koreans
    S W Kang
    Department of Oral Pathology and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea
    Oral Dis 17:399-406. 2011
    b>Dental caries is greatly influenced disease by environmental factors, but recently there are increasing evidences for a genetic component in caries susceptibility...
  64. ncbi Relationships between oral diseases and impacts on Thai schoolchildren's quality of life: evidence from a Thai national oral health survey of 12- and 15-year-olds
    Sudaduang Krisdapong
    Department of Community Dentistry, Chulalongkorn University, Bangkok, Thailand
    Community Dent Oral Epidemiol 40:550-9. 2012
    ..To assess the associations between oral disease and oral health-related quality of life (OHRQoL) in a nationally representative sample of 12- and 15-year-old Thai populations...
  65. pmc Molecular analysis of microbial diversity in advanced caries
    Kim Ly Chhour
    Institute of Dental Research, Westmead Centre for Oral Health, Wentworthville, NSW 2145, Australia
    J Clin Microbiol 43:843-9. 2005
    ..Propionibacterium sp., and Pseudoramibacter alactolyticus. The mechanisms by which such diverse patterns of bacteria extend carious lesions, including the aspect of infection of the vital dental pulp, remain unclear...
  66. ncbi Randomized trial on fluorides and sealants for fissure caries prevention
    B Y Liu
    Faculty of Dentistry, University of Hong Kong, 3 F, Prince Philip Dental Hospital, Hong Kong SAR
    J Dent Res 91:753-8. 2012
    ..gov number CT01446107)...
  67. pmc Impact of treating dental caries on schoolchildren's anthropometric, dental, satisfaction and appetite outcomes: a randomized controlled trial
    Heba A Alkarimi
    King Fahad Armed Forces Hospital, PO Box 54146, Jeddah 21514, Saudi Arabia
    BMC Public Health 12:706. 2012
    There are no randomized controlled trials to assess the impact of treating dental caries on various aspects of children's health...
  68. ncbi The antimicrobial peptide DEFB1 is associated with caries
    A Ozturk
    Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 89:631-6. 2010
    ..No association between DEFB1 genetic markers and periodontal disease was found. Our results suggest that functional polymorphisms of DEFB1 are potential markers for caries...
  69. pmc Molecular analysis of the microflora associated with dental caries
    M A Munson
    Infection Research Group, The Dental Institute, King s College London, United Kingdom
    J Clin Microbiol 42:3023-9. 2004
    ..05, Wilcoxon matched pairs, signed ranks test). In conclusion, combined cultural and molecular analyses have shown that a diverse bacterial community is found in dentinal caries and that numerous novel taxa are present...
  70. pmc A systematic review of socioeconomic indicators and dental caries in adults
    Simone M Costa
    School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte 31270 901, Brazil
    Int J Environ Res Public Health 9:3540-74. 2012
    Increasing evidence suggests that socioeconomic factors may be associated with an increased risk of dental caries. To provide better evidence of the association between dental caries in adults and socioeconomic indicators, we evaluated ..
  71. ncbi Dental caries and its relationship to bacterial infection, hypoplasia, diet, and oral hygiene in 6- to 36-month-old children
    P Milgrom
    Department of Dental Public Health Sciences, University of Washington, Seattle 98195, USA
    Community Dent Oral Epidemiol 28:295-306. 2000
    ..Caufield et al. (1) have suggested that the acquisition of mutans streptococci in young children most likely takes place during a "window of infectivity" from 19 to 31 months of age...
  72. pmc Survival of atraumatic restorative treatment (ART) sealants and restorations: a meta-analysis
    Rodrigo G de Amorim
    Department of Dentistry, Faculty of Health Science, University of Brasilia, Brasilia, Federal District, Brazil
    Clin Oral Investig 16:429-41. 2012
    ..The short-term survival rates of single-surface ART restorations in primary and permanent teeth, and the caries-preventive effect of ART sealants were high...
  73. ncbi Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans
    S Slawik
    Department of Prosthetic Dentistry and Biomedical Materials Science, Hanover Medical School, Hanover, Germany
    Eur J Clin Nutr 65:857-63. 2011
    ..To determine the effects of a probiotic milk drink consumed over a period of 28 days, regarding the expression of clinical inflammatory parameters of the oral gingiva during various phases of plaque-induced gingivitis...
  74. ncbi Caries prevalence and severity, and quality of life in Brazilian 2- to 4-year-old children
    Cristina M F Gradella
    Faculdade de Macapá, Department of Pediatric Dentistry, School of Dentistry, Macapá, Brazil
    Community Dent Oral Epidemiol 39:498-504. 2011
    ..The purpose of this study was to assess the impact of caries and severe caries on preschool children's quality of life...
  75. ncbi Fluoride: its role in dentistry
    Livia Maria Andalo Tenuta
    Biochemistry and Cariology Piracicaba Dental School, University of Campinas UNICAMP, Piracicaba, SP, Brazil
    Braz Oral Res 24:9-17. 2010
    In spite of decades of research on fluoride and the recognition of its role as the cornerstone of dental caries reduction in the last fifty years, questions still arise on its use at community, self-applied and professional application ..
  76. ncbi Caries risk profiles in Sardinian schoolchildren using Cariogram
    Guglielmo Campus
    Dental Institute, University of Sassari, Sassari, Italy
    Acta Odontol Scand 67:146-52. 2009
    ..The aim of our study was to assess the caries risk profile in a group of Sardinian schoolchildren and to compare the outcome with their history of caries...
  77. ncbi Young children's Oral Health-Related Quality of Life and dental fear after treatment under general anaesthesia: a randomized controlled trial
    Marleen A Klaassen
    Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam ACTA, Amsterdam, The Netherlands
    Eur J Oral Sci 117:273-8. 2009
    ..In the total CFSS-DS scores no effects were found. The results of this study showed that the child's OHRQoL improved after treatment under GA. Furthermore, children need guidance in reducing dental fear after treatment under GA...
  78. ncbi Effect of long-term consumption of milk supplemented with probiotic lactobacilli and fluoride on dental caries and general health in preschool children: a cluster-randomized study
    C Stecksen-Blicks
    Department of Odontology, Paediatric Dentistry, Faculty of Medicine, Umea University, Umea, Sweden
    Caries Res 43:374-81. 2009
    ..It is concluded that daily consumption of milk containing probiotic bacteria and fluoride reduced caries in preschool children with a prevented fraction of 75%. Additional beneficial health effects were evident...
  79. pmc Taste genes associated with dental caries
    S Wendell
    Center for Oral Health Research in Appalachia, University of Pittsburgh, PA, USA
    J Dent Res 89:1198-202. 2010
    b>Dental caries is influenced by a complex interplay of genetic and environmental factors, including dietary habits. Previous reports have characterized the influence of genetic variation on taste preferences and dietary habits...
  80. pmc Association between enamel hypoplasia and dental caries in primary second molars: a cohort study
    L Hong
    Department of Dental Public Health and Behavioral Science, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108 2784, USA
    Caries Res 43:345-53. 2009
    ..Enamel hypoplasia appears to be a significant risk factor for caries and should be considered in caries risk assessment...
  81. ncbi Effects of silver diamine fluoride on dentine carious lesions induced by Streptococcus mutans and Actinomyces naeslundii biofilms
    Chun Hung Chu
    The University of Hong Kong, China
    Int J Paediatr Dent 22:2-10. 2012
    ..mutans or A. naeslundii formed on dentine surfaces. SDF slowed down demineralization of dentine. This dual activity could be the reason behind clinical success of SDF...
  82. pmc Elevated incidence of dental caries in a mouse model of cystic fibrosis
    Marcelo A Catalán
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 6:e16549. 2011
    b>Dental caries is the single most prevalent and costly infectious disease worldwide, affecting more than 90% of the population in the U.S...
  83. ncbi The correct use of the ART approach
    Jo E Frencken
    Nijmegen International Centre for Oral Health, Radboud University Nijmegen Medical Centre, College of Dental Sciences, The Netherlands, Nijmegen
    J Appl Oral Sci 18:1-4. 2010
    ..Adherence to its original description is suggested and two major aspects were addressed: the use of hand instruments only and the use of adhesive materials and systems...
  84. ncbi Income, income inequality, dental caries and dental care levels: an ecological study in rich countries
    E Bernabe
    Department of Epidemiology and Public Health, University College London, London, UK
    Caries Res 43:294-301. 2009
    ..The objective of this study was to assess the relationships of income and income inequality with dental caries and dental care levels in 35- to 44-year-old adults among rich countries...
  85. ncbi Dental health and disease determinants among 35-year-olds in Oslo, Norway
    Rasa Skudutyte-Rysstad
    Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway
    Acta Odontol Scand 67:50-6. 2009
    ..The aim of the present study was to identify non-biological determinants associated with the number of sound teeth (ST) and presence of decayed surfaces (DS) among 35-year-old Oslo citizens...
  86. ncbi Oral health during pregnancy
    Hugh Silk
    University of Massachusetts Medical School and Family Medicine Residency Program, Worcester, MA, USA
    Am Fam Physician 77:1139-44. 2008
    ..preterm birth and low birth weight, and high levels of cariogenic bacteria in mothers can lead to increased dental caries in the infant...
  87. ncbi [Caries prevalence in preschool children with overweight and obesity]
    María Lilia Adriana Juárez-López
    Departamentos de Estomatologia Pediátrica y Odontología
    Rev Invest Clin 62:115-20. 2010
    ....
  88. ncbi Sociobehavioural risk factors in dental caries - international perspectives
    Poul Erik Petersen
    Oral Health Programme, Department of Chronic Disease and Health Promotion, World Health Organization, Geneva, Switzerland
    Community Dent Oral Epidemiol 33:274-9. 2005
    ..Most studies of sociobehavioural risk factors in dental caries have been carried out in industrialized countries, but such reports from low- and middle-income countries have ..
  89. ncbi The influence of a novel propolis on mutans streptococci biofilms and caries development in rats
    Simone Duarte
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, NY 14620, USA
    Arch Oral Biol 51:15-22. 2006
    ..propolis (EEP) and its purified hexane fraction (EEH) on mutans streptococci biofilms and the development of dental caries in rats...
  90. ncbi Social deprivation, income inequality, social cohesion and dental caries in Brazilian school children
    M P Pattussi
    Community Dental Officer in Brasilia, Taguatinga
    Soc Sci Med 53:915-25. 2001
    ..study investigated the associations between social deprivation, income inequality and social cohesion and dental caries levels in school children of the Distrito Federal, Brazil...
  91. ncbi Pit and fissure sealants in the prevention of dental caries in children and adolescents: a systematic review
    Amir Azarpazhooh
    Department of Endodontics, Community Dental Health Services Research Unit, Faculty of Dentistry, University of Toronto, Toronto, Ontario
    J Can Dent Assoc 74:171-7. 2008
    ..To investigate the evidence for sealants as a means to prevent caries in children and adolescents and, in the presence of suitable supporting evidence, to develop a protocol for the application of sealants...
  92. ncbi Mechanisms of action of fluoride for caries control
    Marilia Afonso Rabelo Buzalaf
    Department of Biological Sciences, Orthodontics and Public Health, Bauru Dental School, University of Sao Paulo, Bauru, Brazil
    Monogr Oral Sci 22:97-114. 2011
    ..Evidence also supports fluoride's systemic mechanism of caries inhibition in pit and fissure surfaces of permanent first molars when it is incorporated into these teeth pre-eruptively...
  93. ncbi Acquired enamel pellicle and its potential role in oral diagnostics
    W L Siqueira
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    Ann N Y Acad Sci 1098:504-9. 2007
    ..Recent developments in both pellicle collection methods and nanoscale sensing technologies have brought the exploitation of pellicle analysis into the realm of point-of-care oral diagnostics...
  94. ncbi A critical review: an overview of genetic influence on dental caries
    R I Werneck
    Center for Health and Biological Sciences, Pontifical Catholic University of Parana PUCPR, Curitiba, Parana, Brazil
    Oral Dis 16:613-23. 2010
    ..from several biological and environmental factors, and the small number of genetic studies related to dental caries, the genetic basis still requires further study...
  95. pmc Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivo
    H Koo
    Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA hyun_koo urmc rochester edu
    Caries Res 44:116-26. 2010
    ..mutans biofilm formation on saliva-coated hydroxyapatite surface, and on dental caries development in Sprague-Dawley rats...
  96. ncbi Association between infant breastfeeding and early childhood caries in the United States
    Hiroko Iida
    Department of Dentistry, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA
    Pediatrics 120:e944-52. 2007
    ..The objective of this study was to assess the potential association of breastfeeding and other factors with the risk for early childhood caries among young children in the United States...
  97. ncbi Twenty-four month incidence of root caries among a diverse group of adults
    G H Gilbert
    School of Dentistry, University of Alabama at Birmingham, Ala 35294 0007, USA
    Caries Res 35:366-75. 2001
    ..1) Describe for a diverse sample the 24-month incidence of root caries, and (2) test its association with a broad range of clinical, behavioral, financial, and sociodemographic factors...
  98. ncbi Dental caries in six, 12 and 15 year old Venda children in South Africa
    A S Bajomo
    Division of Public Oral Health, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa
    East Afr Med J 81:236-43. 2004
    ..The emerging district health system with decentralisation of health services to address past inequity in health care in South Africa also provides compelling case for data collection at regional levels...
  99. ncbi Nursing caries, linear hypoplasia, and nursing and weaning habits in Tanzanian infants
    M Matee
    Department of Microbiology, Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania
    Community Dent Oral Epidemiol 22:289-93. 1994
    ....
  100. ncbi The oral health of psychiatric in-patients in South Wales
    S Lewis
    Department of Adult Dental Health, University of Wales College of Medicine, Heath Park, Cardiff CF144XY, Wales, UK
    Spec Care Dentist 21:182-6. 2001
    ..The oral hygiene of the dentate population was poor, and there was little periodontal disease. Treatment needs were mainly for scaling and polishing. There were no significant differences found between subgroups within the population...
  101. ncbi Cochrane reviews of randomized trials of fluoride therapies for preventing dental caries
    V C C Marinho
    Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Institute of Dentistry, Turner Street, London, UK
    Eur Arch Paediatr Dent 10:183-91. 2009
    ..To present the evidence summarized in the Cochrane fluoride reviews...

Research Grants73

  1. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..biofilms include bacterial endocarditis, cystic fibrosis lung infections, deep wound healing, the current dental caries epidemic, periodontal disease, vaginosis, urinary tract infections, and chronic middle ear infections...
  2. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dental caries (tooth decay) remains a significant national and international health problem, especially in low- income and disadvantaged populations...
  3. MEMBRANES OF THE DENTAL PATHOGEN STREPTOCOCCUS MUTANS
    L Jeannine Brady; Fiscal Year: 2013
    b>Dental caries results in 25-30 billion dollars in annual health care costs in the US and is caused by the pathogenic bacterium Streptococcus mutans...
  4. Development and Validation of an Instrument to Assess Cognitive Function Regulati
    Xi Chen; Fiscal Year: 2013
    ..decisions, performing oral hygiene care, and following homecare instructions), remarkably increasing risk of dental caries, periodontal disease and other oral health issues...
  5. Multivariate CART for survival with dental applications
    Martha E Nunn; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tooth loss from periodontal disease or dental caries afflicts most adults over the course of their lives...
  6. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..Xylitol has been shown to prevent progression of dental caries, and decrease the incidence of acute otitis media...
  7. Contribution of the Streptococcus mutans cid and lrg Murein Hydrolase Regulator H
    KELLY CHRISTINE RICE; Fiscal Year: 2010
    Streptococcus mutans is the primary causative agent of dental caries, which remains the most common chronic disease among children and is untreated in up to 30% of adults over 35 yrs-old...
  8. Transforming Women's Health: Discovery, Development, and Delivery
    Ellen M Daley; Fiscal Year: 2012
    ..Moreover, several oral-systemic linkages associated with poor oral health (i.e. periodontitis;oral bone loss;dental caries) that solely or disproportionally affect women include various infectious (HIV/AIDS), chronic (cardiovascular ..
  9. Expression of clp genes in Streptococcus mutans
    Indranil Biswas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans is considered as the major etiological agent in dental caries. S. mutans is also an important agent of infective endocarditis...
  10. Genetics and Genomics of the yidC paralogs in Streptococcus mutans
    SARA MARIE RASER PALMER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans is the primary etiological agent of dental caries (cavities), but the bacterium also causes endocarditis and is strongly associated with cardiovascular disease and stroke...
  11. Individual Predoctoral Dental Scientist Fellowship
    Angela Gullard; Fiscal Year: 2013
    ..studies will facilitate the development of novel diagnostic tools and therapeutic treatments for patients with dental caries, various tooth/bone mineralization disorders, or syndromes with altered dentin formation...
  12. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace A Spatafora; Fiscal Year: 2013
    ..health in the United States, recent reports reveal no significant improvement in the prevalence or severity of dental caries in the primary dentition (64, 120)...
  13. The effect of inter-species interactions on the virulence of Streptococcus mutans
    Bing yan Wang; Fiscal Year: 2009
    ..iv) We will determine if the proteinases of P. gingivalis inactivate the S. mutans CSP. Project Narrative: Dental caries is a common chronic infectious disease affecting much of the worldwide population. The S...
  14. Dental Caries: Whole Genome Association and Gene x Environment Studies
    Mary L Marazita; Fiscal Year: 2010
    b>Dental caries (also known as tooth decay) remains the most common chronic disease of childhood...
  15. Investigating SloR virulence gene metalloregulation in S. mutans.
    Grace Spatafora; Fiscal Year: 2009
    ..health in the United States, recent reports reveal no significant improvement in the prevalence or severity of dental caries in the primary dentition (62, 115)...
  16. Functional Amyloid Formation in Streptococcus mutans
    L Jeannine Brady; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dental caries is the most common infectious disease in the world caused in large part by the Gram-positive bacterium Streptococcus mutans...
  17. Role of the Spx Regulator in Streptococcus mutans
    JOSE A LEMOS; Fiscal Year: 2013
    ..clinical and basic research have implicated Streptococcus mutans as the primary microbial etiologic agent of dental caries, one of the most common infectious diseases afflicting humans. The virulence of S...
  18. Studies of YlxM of Streptococcus mutans, a newly identified component of the Sign
    MATTHEW LAWRENCE WILLIAMS; Fiscal Year: 2013
    ..Human dental caries is a ubiquitous infectious disease that represents 5-10% of healthcare expenditures in industrialized nations...
  19. Combinatorial Imaging of the Oral Microbiome
    Floyd E Dewhirst; Fiscal Year: 2010
    ..and the oral microbial community is involved in the development of several infectious diseases such as dental caries, periodontal disease, alveolar osteitis, tonsillitis, strep throat and otitis media...
  20. Effects on Caffeine on Adolescent Behavior and Physiology
    Jennifer L Temple; Fiscal Year: 2010
    ..risks from consuming caffeine, soda tends to contain high levels of sugar, which puts children at risk for dental caries and overweight...
  21. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Dental caries, commonly known as tooth decay, is a serious health problem all over the world, and is one of the most common infectious diseases in humans...
  22. A qualitative description of a pilot project to improve access to care in one Den
    SARAH ELAINE RASKIN; Fiscal Year: 2011
    ..Page 1 of 1 Qualitative description of a dental health pilot project ..
  23. Oral Health in Breast Cancer Survivors on Aromatase Inhibitors
    Linda Susan Taichman; Fiscal Year: 2013
    ..Comprehensive oral examinations (including assessment of mucosal lesions, periodontal measures, dental caries, oral x-rays, oral fluid, and tooth loss examination will be performed)...
  24. Northwest/Alaska/Hawaii Center to Reduce Oral Health Disparities
    PETER M MILGROM; Fiscal Year: 2012
    ..research plan are to: 1) Conduct human trials to evaluate the efficacy of interventions to prevent and treat dental caries in children and their caretakers;2) Develop community-based research that translates existing knowledge and ..
  25. Leveraging Opportunities to Improve Oral Health in Older Adults
    MARY EVELYN NORTHRIDGE; Fiscal Year: 2011
    ..chronic illness) may be particularly important in influencing dental health outcomes such as tooth retention, dental caries, and periodontal disease...
  26. Making a quantum leap in plaque research with modern sciences
    Wenyuan Shi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Current tooth decay (dental caries) prevention methods include enamel hardening with fluoride and bacterial removal via mechanical and general antimicrobial approaches...
  27. Development of targeted photodynamic therapy for treatment of dental caries
    Randal Eckert; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dental caries (tooth decay) is one of the most prevalent and costly infectious diseases in the United States...
  28. Oxidative Stress in Oral Streptococci
    Robert E Marquis; Fiscal Year: 2010
    ..to develop effective antimicrobial for control of Dental plaque pathogenicity, primarily related to Dental caries. The Specific Aims of the project are the following...
  29. Proteomics and Genetics of Enamel and Dentin
    James P Simmer; Fiscal Year: 2013
    ..Future genetic analyses may link genetic changes in these genes to susceptibility for dental caries and provide insights into mechanisms of tooth formation.
  30. Longitudinal Study of Dental Caries in VLBW Infants
    Suchitra S Nelson; Fiscal Year: 2013
    ..It is also of public health interest since interventions to target knowledge, attitude, beliefs, and oral health practices can be implemented in programs for special needs children, and there by improve both oral and systemic health. ..
  31. Caregiver Illness Perception and Childs Early Childhood Caries Status
    Mary Beth Slusar; Fiscal Year: 2013
    ..predisposing and enabling factors, and need influence parents'illness perception of their child's dental caries (tooth decay)...
  32. Inhibition of oral bacterial biofilm formation using natural products-inspired or
    NATHANIEL CHARLES CADY; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Oral bacterial biofilms are major contributors to tooth decay (dental caries) and are a potential conduit for infection and disease...
  33. SIPsmartER: A nutrition literacy approach to reducing sugar-sweetened beverages
    Jamie Zoellner; Fiscal Year: 2013
    ..e. obesity, type II diabetes, coronary heart disease, dental caries, and cancer), bridge the conceptual gap among concepts in health behavior theory and health literacy, expand ..
  34. Regulation of Oral Bacteria by Pattern Recognition Receptors
    Naohiro Inohara; Fiscal Year: 2012
    ..community of bacteria, some of which have been implicated as etiological agents of common diseases such as dental caries and periodontitis...
  35. Internalization of S. mutans in vascular endothelial cells
    Ann Progulske-Fox; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Streptococcus mutans (Sm) has long been recognized as a major pathogen of dental caries, the most common infectious disease in humans...
  36. GENETICALLY ENGINEERED ORAL VACCINES AND CARIES IMMUNITY
    Suzanne M Michalek; Fiscal Year: 2012
    ..potential use in the development of mucosal vaccines protective against various infectious diseases including dental caries. However, the mechanism(s) by which these safe, live vector vaccines mediate host responses are still poorly ..
  37. Intracellular Invasion by Streptococcus mutans: Significance in Disease
    JOSE A LEMOS; Fiscal Year: 2013
    ..Streptococcus mutans, a major etiologic agent of dental caries, is also a leading causative agent of infective endocarditis (IE) and has been implicated in the development ..
  38. Dentin Fluoride as a Biomarker for Childhood Fluoride Intake
    JAMES STERN WEFEL; Fiscal Year: 2010
    The reduction in dental caries over the past 30+ years has been remarkable and started largely with the introduction of fluoride to the water supply...
  39. Roles of Streptococcus mutans YidC1 and YidC2 in membrane biogenesis
    SARA RASER PALMER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Streptococcus mutans is the etiological agent of dental caries costing billions of dollars annually in associated health care...
  40. Prevention of Dental Caries in Early Head Start Children
    RICHARD GARY ROZIER; Fiscal Year: 2012
    ..The result of successful implementation of preventive dental programs should be less disease and improved quality of life among children and their families. ..
  41. Validation of New Diagnostic Technologies for Dental Caries
    JAMES STERN WEFEL; Fiscal Year: 2010
    During the past 40 years there has been a remarkable decline in the prevalence of dental caries in children and adults due to the widespread use of fluoride in public health programs, such as communal water fluoridation, dental practice ..
  42. Probing oral pathogen interactions in picoliter-scale enclosures
    AIMEE KATHERINE WESSEL; Fiscal Year: 2013
    ..mutans, the primary causative agent of dental caries in humans...
  43. NIDCR Dentist Scientist K99;Function and Regulation of Perp in Amelogenesis
    Andrew H Jheon; Fiscal Year: 2013
    ..amelogenesis is important to devise new and improved strategies in the prevention, diagnosis, and treatment of dental caries and inherited disorders such as amelogenesis imperfecta...
  44. Oral Home Telecare for Tetraplegics
    Hon K Yuen; Fiscal Year: 2010
    ..dry mouth from xerostomia-causing medications (commonly used in this population) increase the likelihood of dental caries and periodontal disease...
  45. NIDCR Dentist Scientist K99;Function and Regulation of Perp in Amelogenesis
    Andrew H Jheon; Fiscal Year: 2012
    ..amelogenesis is important to devise new and improved strategies in the prevention, diagnosis, and treatment of dental caries and inherited disorders such as amelogenesis imperfecta...
  46. Epidemiology of Dental Caries and Immunity in Children
    Noel K Childers; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dental caries is an infectious and transmissible disease that is multifactorial &complex, however, the mutans streptococci (MS) are consistently implicated in the etiology...
  47. A novel glycosylation-associated protein is required for fimbriae biogenesis
    Haley L Echlin; Fiscal Year: 2013
    ..The most far-reaching example of disease is dental caries and inflammatory periodontal disease since the main portal of entry into the human body is through the oral ..
  48. CHD1, Chromatin Dynamics, and Salivary Gland Differentiation
    JOSEPH ADAM HALL; Fiscal Year: 2010
    ..by difficulty in phonation and deglutition, mucosal ulcerations, and an increase in the frequency of dental caries. One of the major contributors to xerostomia is an autoimmune disorder known as Sjogren's Syndrome which ..
  49. Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients
    Rajesh V Lalla; Fiscal Year: 2013
    ..adverse effects, including irreversible hyposalivation and xerostomia, which result in increased rates of dental caries and tooth loss...
  50. MicroRNAs and Parotid Acinar Cell Differentiation
    Melissa A Metzler; Fiscal Year: 2013
    ..in quality of life for these patients as well as a reduction in overall oral health as the incidence of dental caries and periodontal disease increases...
  51. Oral Health of Latino and Ethiopian Children and Their Mothers
    Olivia Carter Pokras; Fiscal Year: 2009
    ..b>Dental caries and its complications are specifically targeted by the National Institute of Dental and Craniofacial Research&..
  52. Microfluidic devices for studying genetic competence in Streptococcus mutans
    STEPHEN JAMES HAGEN; Fiscal Year: 2010
    ..such as Streptococcus mutans generates acid waste products that accumulate near the tooth surface, leading to dental caries. This project focuses on the genetic competence of Streptococcus mutans in oral biofilms...
  53. Novel Antibacterial Fluoride-releasing Dental Materials
    Xiaoming Xu; Fiscal Year: 2012
    ..b>Dental caries continues to be a worldwide pandemic disease...
  54. Oral care treatment for mobility-impaired patients
    Sheldon E Broedel; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Biofilm infections are a major cause of mortality and morbidity. Dental caries occur as a result of an infectious disease in the oral cavity that is characterized by localized demineralization of ..
  55. Moving Beyond Diversity by Revealing Biological Functions of Uncultured Bacteria
    JEFFREY SCOTT MCLEAN; Fiscal Year: 2013
    ..This will have a great impact on the future clinical management of dental caries and provide a comprehensive approach for characterizing the function of species and their interactions for ..
  56. Factors Contributing to Oral Health Disparities in Appalachia
    Daniel W McNeil; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dental caries is a very different disease than it was forty years ago. While caries is declining in general, caries rates in young children (ages 2-5) in the US have been increasing (US GAO, 2008)...
  57. Microbiome analysis of human oral bacteriophage communities
    DAVID TEVIS PRIDE; Fiscal Year: 2013
    ..analysis of bacteriophages may provide important clues as to the development of both periodontitis and dental caries in our human subjects...
  58. Family intervention with caregivers of children with urgent dental needs
    Suchitra S Nelson; Fiscal Year: 2012
    ..in two phases: (1) pilot phase to validate the modified illness perception questionnaire -Revised (IPQ-RD) for dental caries, acceptability and delivery of the intervention, mediators and moderators for accessing care;focus groups of ..
  59. Characterization of a unique two-component system in streptococci
    Indranil Biswas; Fiscal Year: 2013
    ..S. mutans is considered to be the primary etiological agent of dental caries and sometimes in infective endocarditis...
  60. High-resolution ex vivo micro-computerized tomography system
    Mary F Barbe; Fiscal Year: 2010
    ..3) Detection of the earliest stages of dental caries and the development of preventative and treatment interventions...
  61. Engineering Functioning Salivary Glands Using Micropatterned Scaffolds
    Melinda Larsen; Fiscal Year: 2010
    ..patients, lack of saliva production causes significant morbidity due to dry mouth that results in dysphasia, dental caries, oropharyngeal infections, mucositis, and loss of taste...
  62. Targeting Oral Biofilms with 2-Aminoimidazole/Triazole Conjugates
    Eva Garland; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dental caries, or tooth decay, affects hundreds of millions of people each year, and is second only to the common cold in its prevalence world-wide...
  63. PREVENT TRANSMIS OF MUTANS STREPTOC FR MOTHER TO CHILD
    Walter Bretz; Fiscal Year: 2004
    ..abstract_text> ..
  64. REGULATION OF IMMUNE RESPONSE IN THE ORAL CAVITY
    Suzanne Michalek; Fiscal Year: 2003
    ..antibodies in saliva are important in protection against oral diseases, including Streptococcus mutans-induced dental caries, and are induced following stimulation of the common mucosal immune system (CMIS)...
  65. Developing acid-activated antimicrobial peptides to control dental caries
    Maxwell Anderson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Dental caries (tooth decay) is one of the most prevalent and costly infectious diseases in the United States...
  66. Hyperbaric O2 Stimulation of Salivary Flow in Radiation -induced Xerostomia
    Michael Martin; Fiscal Year: 2009
    ..important health problem contributing to poor nutrition (inability to eat), significantly increased rates of dental caries and other oral infections, inability to wear dentures due to decreased oral moisture, diminished gustatory ..
  67. Xylitol Adult Caries Trial (X-ACT)--UNC Clinical Center
    Daniel A Shugars; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dental caries incidence is higher in adults than children...
  68. Xylitol Adult Caries Trial (X-ACT)--Study Chair application
    James D Bader; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dental caries incidence is higher in adults than children...
  69. Xylitol Adult Caries Trial (X-ACT): UAB Clinical Center
    Gregg H Gilbert; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dental caries incidence is higher in adults than children...
  70. Xylitol Adult Caries Trial (X-ACT) UTHSC San Antonio Clinical Center
    Bennett Tochukwu Amaechi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dental caries incidence is higher in adults than children...
  71. Statistical Methods for Complex Dependent Dental Data
    David Todem; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): Despite numerous statistical analyses to assess the pattern of dental caries in primary dentition, there are still some fundamental questions that remain unanswered...
  72. Oral Health Problems of BPD and VLBW adolescents
    Suchitra Nelson; Fiscal Year: 2005
    ..literature about the relationship between very low birth weight (VLBW), bronchopulmonary dysplasia (BPD) and dental caries in the permanent dentition, due to the fact that only recently are increasing numbers surviving to adolescence ..
  73. Xylitol Adult Caries Trial (X-ACT) Data Coordinating Center
    WILLIAM MARION VOLLMER; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Dental caries incidence is higher in adults than children...