dental plaque

Summary

Summary: A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.

Top Publications

  1. ncbi Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions
    A Ashimoto
    Department of Periodontology, School of Dentistry, University of Southern California, Los Angeles 90089 0641, USA
    Oral Microbiol Immunol 11:266-73. 1996
  2. ncbi Periodontal diseases
    Bruce L Pihlstrom
    Center for Clinical Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 6401, USA
    Lancet 366:1809-20. 2005
  3. ncbi Pyrosequencing analysis of the oral microflora of healthy adults
    B J F Keijser
    TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Zeist, The Netherlands
    J Dent Res 87:1016-20. 2008
  4. pmc Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions
    Christina J Adler
    Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, The University of Adelaide, Adelaide, South Australia, Australia
    Nat Genet 45:450-5, 455e1. 2013
  5. ncbi Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencing
    Zongxin Ling
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
    Microb Ecol 60:677-90. 2010
  6. pmc Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray
    Ana Paula V Colombo
    Department of Medical Microbiology, Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    J Periodontol 80:1421-32. 2009
  7. ncbi The breadth of bacterial diversity in the human periodontal pocket and other oral sites
    Bruce J Paster
    Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts, USA
    Periodontol 2000 42:80-7. 2006
  8. ncbi Periodontal microbial ecology
    Sigmund S Socransky
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:135-87. 2005
  9. pmc The dental plaque microbiome in health and disease
    Scott N Peterson
    J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS ONE 8:e58487. 2013
  10. pmc Interspecies interactions within oral microbial communities
    Howard K Kuramitsu
    Department of Oral Boiology, School of Dental Medicine, State University of New York, Buffalo, New York, USA
    Microbiol Mol Biol Rev 71:653-70. 2007

Detail Information

Publications319 found, 100 shown here

  1. ncbi Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions
    A Ashimoto
    Department of Periodontology, School of Dentistry, University of Southern California, Los Angeles 90089 0641, USA
    Oral Microbiol Immunol 11:266-73. 1996
    ..The results indicated a strong association between the study species and periodontitis. Several previously unreported symbiotic relationships were found between the 8 species tested...
  2. ncbi Periodontal diseases
    Bruce L Pihlstrom
    Center for Clinical Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 6401, USA
    Lancet 366:1809-20. 2005
    ..Gingivitis, the mildest form of periodontal disease, is caused by the bacterial biofilm (dental plaque) that accumulates on teeth adjacent to the gingiva (gums)...
  3. ncbi Pyrosequencing analysis of the oral microflora of healthy adults
    B J F Keijser
    TNO Quality of Life, Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, Zeist, The Netherlands
    J Dent Res 87:1016-20. 2008
    ..This work gives a radically new insight into the diversity of human oral microflora, which, with an estimated number of 19,000 phylotypes, is considerably higher than previously reported...
  4. pmc Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions
    Christina J Adler
    Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, The University of Adelaide, Adelaide, South Australia, Australia
    Nat Genet 45:450-5, 455e1. 2013
    ..Here, we show that calcified dental plaque (dental calculus) on ancient teeth preserves a detailed genetic record throughout this period...
  5. ncbi Analysis of oral microbiota in children with dental caries by PCR-DGGE and barcoded pyrosequencing
    Zongxin Ling
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
    Microb Ecol 60:677-90. 2010
    ....
  6. pmc Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray
    Ana Paula V Colombo
    Department of Medical Microbiology, Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    J Periodontol 80:1421-32. 2009
    ....
  7. ncbi The breadth of bacterial diversity in the human periodontal pocket and other oral sites
    Bruce J Paster
    Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts, USA
    Periodontol 2000 42:80-7. 2006
  8. ncbi Periodontal microbial ecology
    Sigmund S Socransky
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:135-87. 2005
  9. pmc The dental plaque microbiome in health and disease
    Scott N Peterson
    J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS ONE 8:e58487. 2013
    ..microbial species involved in dental caries and health by performing a comprehensive 16S rDNA profiling of the dental plaque microbiome of both caries-free and caries-active subjects...
  10. pmc Interspecies interactions within oral microbial communities
    Howard K Kuramitsu
    Department of Oral Boiology, School of Dental Medicine, State University of New York, Buffalo, New York, USA
    Microbiol Mol Biol Rev 71:653-70. 2007
    ..With the common name "dental plaque," oral microbial communities are some of the most complex microbial floras in the human body, consisting ..
  11. pmc Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)
    Moise Desvarieux
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn, USA
    Circulation 111:576-82. 2005
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and subclinical atherosclerosis...
  12. ncbi Bacterial interactions and successions during plaque development
    Paul E Kolenbrander
    Oral Infection and Immunity Branch, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Periodontol 2000 42:47-79. 2006
  13. pmc Virulence factors of the oral spirochete Treponema denticola
    S G Dashper
    Cooperative Research Centre for Oral Health, Melbourne Dental School and Bio21 Institute, The University of Melbourne, 720 Swanston Street, Victoria 3010, Australia
    J Dent Res 90:691-703. 2011
    ..Recent advances, especially in molecular-based methodologies, have greatly improved our knowledge of this bacterium and its role in disease...
  14. ncbi Dental plaque, platelets, and cardiovascular diseases
    M C Herzberg
    School of Dentistry, University of Minnesota, Minneapolis, USA
    Ann Periodontol 3:151-60. 1998
    ..During periodontitis, dental plaque microorganisms may disseminate through the blood to infect the vascular endothelium and contribute to the ..
  15. pmc Drinking habits are associated with changes in the dental plaque microbial community
    Caterina Signoretto
    Dipartimento di Patologia, Sezione di Microbiologia, Universita di Verona, Strada Le Grazie, 8, Verona 37134, Italy
    J Clin Microbiol 48:347-56. 2010
    ..and gingivitis are the most prevalent oral infectious diseases of humans and are due to the accumulation of dental plaque (a microbial biofilm) on the tooth surface and at the gingival margin, respectively...
  16. ncbi Effect of a mouthrinse containing selected propolis on 3-day dental plaque accumulation and polysaccharide formation
    Hyung Koo
    Department of Dentistry, University of Rochester Medical Center, Rochester, NY, USA
    Caries Res 36:445-8. 2002
    The aim of this study was to evaluate the effect of a mouthrinse containing propolis SNB-RS on 3-day dental plaque accumulation. Six volunteers took part in a double-blind crossover study performed in two phases of 3 days...
  17. ncbi A mixed-bacteria ecological approach to understanding the role of the oral bacteria in dental caries causation: an alternative to Streptococcus mutans and the specific-plaque hypothesis
    I Kleinberg
    Department of Oral Biology and Pathology, State University of New York, Stony Brook, New York 11794 8702, USA
    Crit Rev Oral Biol Med 13:108-25. 2002
    ..In the 1940s, Stephan found that the mixed bacteria in dental plaque produced a rapid drop in pH following a sugar rinse and a slow pH return toward baseline...
  18. pmc Genetic profiling of the oral microbiota associated with severe early-childhood caries
    Y Li
    Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA
    J Clin Microbiol 45:81-7. 2007
    ..cavity is usually based on cultivation methods; however, nearly half of the bacteria in the saliva and the dental plaque are not cultivable...
  19. pmc Bacterial diversity in human subgingival plaque
    B J Paster
    Department of Molecular Genetics, The Forsyth Institute, Boston, Massachusetts 02115, USA
    J Bacteriol 183:3770-83. 2001
    ..When organisms found on other oral surfaces such as the cheek, tongue, and teeth are added to this number, the best estimate of the total species diversity in the oral cavity is approximately 500 species, as previously proposed...
  20. ncbi Dental plaque: biological significance of a biofilm and community life-style
    P D Marsh
    Leeds Dental Institute, and Health Protection Agency, Centre for Emergency Preparedness and Response, Porton Down, UK
    J Clin Periodontol 32:7-15. 2005
    ..Microbial gene expression alters markedly in biofilms; organisms communicate by gene transfer and by secretion of diffusible signalling molecules. Cells in biofilms are less susceptible to antimicrobial agents...
  21. ncbi The effect of adjunctive chlorhexidine mouthrinse on clinical parameters and gingival crevicular fluid cytokine levels in untreated plaque-associated gingivitis
    O Turkoglu
    School of Dentistry, Department of Periodontology, Ege University, Izmir, Turkey
    Inflamm Res 58:277-83. 2009
    ..To examine the effectiveness of chlorhexidine mouthrinse (CHX) in addition to daily plaque control on gingival inflammation...
  22. ncbi Feeding and oral hygiene habits of preschool children in Hong Kong and their caregivers' dental knowledge and attitudes
    S C L Chan
    Tang Shiu Kin Dental Therapist Training School, MacLehose Dental Centre, Hong Kong SAR, People s Republic of China
    Int J Paediatr Dent 12:322-31. 2002
    ....
  23. ncbi Dental biofilms: difficult therapeutic targets
    Sigmund S Socransky
    Department of Periodontology, The Forsyth Institute, Boston, Massachusetts, USA
    Periodontol 2000 28:12-55. 2002
  24. pmc Characterization of a Streptococcus sp.-Veillonella sp. community micromanipulated from dental plaque
    Natalia I Chalmers
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    J Bacteriol 190:8145-54. 2008
    Streptococci and veillonellae occur in mixed-species colonies during formation of early dental plaque. One factor hypothesized to be important in assembly of these initial communities is coaggregation (cell-cell recognition by ..
  25. pmc Epithelial cell pro-inflammatory cytokine response differs across dental plaque bacterial species
    Panagiota G Stathopoulou
    Center for Oral Health and Systemic Disease, University of Louisville School of Dentistry, University of Louisville, Louisville, KY, USA
    J Clin Periodontol 37:24-9. 2010
    The dental plaque is comprised of numerous bacterial species, which may or may not be pathogenic...
  26. ncbi The in vivo dynamics of Streptococcus spp., Actinomyces naeslundii, Fusobacterium nucleatum and Veillonella spp. in dental plaque biofilm as analysed by five-colour multiplex fluorescence in situ hybridization
    Ali Al-Ahmad
    Department of Operative Dentistry and Periodontology, Albert Ludwigs University, Freiburg, Germany
    J Med Microbiol 56:681-7. 2007
    The formation and composition of dental plaque biofilm in vivo are important factors which influence the development of gingivitis, caries and periodontitis...
  27. ncbi Association of red complex, A. actinomycetemcomitans and non-oral bacteria with periodontal diseases
    Carina Maciel da Silva-Boghossian
    Department of Dental Clinic, Division of Graduate Periodontics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Arch Oral Biol 56:899-906. 2011
    ..This study evaluated the association amongst red complex, A. actinomycetemcomitans (A.a) and non-oral pathogenic bacteria in subjects with good periodontal health (PH), gingivitis (G), chronic (CP) and aggressive (AP) periodontitis...
  28. ncbi Relationship of Actinobacillus actinomycetemcomitans serotype b to aggressive periodontitis: frequency in pure cultured isolates
    H W Yang
    School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, Taiwan
    J Periodontol 75:592-9. 2004
    ..actinomycetemcomitans in A. actinomycetemcomitans isolates from various forms of periodontitis using both old and new diagnostic classifications and to determine the relationships between serotype and age and clinical diagnosis...
  29. ncbi Live/dead real-time polymerase chain reaction to assess new therapies against dental plaque-related pathologies
    G Loozen
    Department of Periodontology, Catholic University of Leuven, Leuven, Belgium
    Mol Oral Microbiol 26:253-61. 2011
    DNA-based methodology for the identification and detection of specific bacteria in dental plaque offers advantages over culturing techniques...
  30. pmc Dental plaque microcosm biofilm behavior on calcium phosphate nanocomposite with quaternary ammonium
    Lei Cheng
    Biomaterials and Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA
    Dent Mater 28:853-62. 2012
    ..to a composite with nanoparticles of amorphous calcium phosphate (NACP); and (2) investigate the effect of quaternary ammonium dimethacrylate (QADM) on mechanical and dental plaque microcosm biofilm properties for the first time.
  31. ncbi Variation in bacterial DGGE patterns from human saliva: over time, between individuals and in corresponding dental plaque microcosms
    Indira A Rasiah
    Dental Research Group, Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, P O Box 7343, Wellington 6039, New Zealand
    Arch Oral Biol 50:779-87. 2005
    Eubacterial 16S rDNA fingerprints of human saliva and dental plaque microcosm biofilms grown in the multi-plaque artificial mouth (MAM) were characterised using denaturing gradient gel electrophoresis (DGGE).
  32. pmc Improved PCR for detection of the highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans in subgingival plaque samples
    Knud Poulsen
    Department of Medical Microbiology and Immunology, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Clin Microbiol 41:4829-32. 2003
    ..Here, we describe and evaluate a set of primers for PCR to assay for the presence of A. actinomycetemcomitans and to discriminate between JP2-like strains and other genotypes in subgingival plaque samples...
  33. ncbi Quantitative detection of periodontopathogens by real-time PCR
    Claudia Nonnenmacher
    Institute of Medical Microbiology and Hygiene, Philipps University, Pilgrimstein 2, Marburg D 35037, Germany
    J Microbiol Methods 59:117-25. 2004
    ..Quantitative real-time PCR thus provides a reliable and valuable method for quantification of periodontopathogens in subgingival plaque samples...
  34. ncbi Genomic library screening for viruses from the human dental plaque revealed pathogen-specific lytic phage sequences
    Ahmed Nasser Al-Jarbou
    Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah, Saudi Arabia
    Curr Microbiol 64:1-6. 2012
    ..However, little is known about virus diversity in human dental plaque which is an important reservoir...
  35. ncbi The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes
    Y Iwamoto
    Department of Periodontology and Endodontology, Okayama University Dental School, Japan
    J Periodontol 72:774-8. 2001
    ..49 pg/ml and 0.8%, respectively. CONCLUSION: The results indicate that anti-infectious treatment is effective in improving metabolic control in diabetics, possibly through reduced serum TNF-alpha and improved insulin resistance...
  36. ncbi Probiotics affect the clinical inflammatory parameters of experimental gingivitis in humans
    S Slawik
    Department of Prosthetic Dentistry and Biomedical Materials Science, Hanover Medical School, Hanover, Germany
    Eur J Clin Nutr 65:857-63. 2011
    ..To determine the effects of a probiotic milk drink consumed over a period of 28 days, regarding the expression of clinical inflammatory parameters of the oral gingiva during various phases of plaque-induced gingivitis...
  37. ncbi Distribution of selected bacterial species on intraoral surfaces
    Donna L Mager
    Department of Periodontology, The Forsyth Institute, Boston, MA 02115, USA
    J Clin Periodontol 30:644-54. 2003
    ..To examine the proportions of 40 bacterial species in samples from 8 oral soft tissue surfaces and saliva in systemically healthy adult subjects and to compare these microbiotas with those of supra- and subgingival plaque...
  38. ncbi Colonization of dental plaque by respiratory pathogens in dependent elderly
    Yasunori Sumi
    Division of Oral and Dental Surgery, Department of Advanced Medicine, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Japan
    Arch Gerontol Geriatr 44:119-24. 2007
    ..Therefore, dental plaques must be considered a specific reservoir of colonization and subsequent aspiration pneumonia in dependent elderly...
  39. ncbi Isolation and characterization of Streptococcus mutans in heart valve and dental plaque specimens from a patient with infective endocarditis
    Ryota Nomura
    Departments of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka 565 0871, Japan
    J Med Microbiol 55:1135-40. 2006
    ..In the present study, infected heart valve and dental plaque samples from a patient with IE were analysed...
  40. pmc Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST)
    Moise Desvarieux
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    J Hypertens 28:1413-21. 2010
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and hypertension...
  41. ncbi Oral microbial communities: biofilms, interactions, and genetic systems
    P E Kolenbrander
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Microbiol 54:413-37. 2000
    ..Identification of contact-inducible genes in streptococci offers an avenue to explore bacterial responses to their environment and leads the way toward understanding communication among inhabitants of a multispecies biofilm...
  42. pmc Microbial risk markers for childhood caries in pediatricians' offices
    E Kanasi
    Department of Molecular Genetics, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA
    J Dent Res 89:378-83. 2010
    ..05) significantly associated with caries by the 'false discovery' rate. Analysis of the data suggests that selected Lactobacillus species, in addition to mutans streptococci, are risk markers for early childhood caries...
  43. ncbi Fluorescence microscopic visualization and quantification of initial bacterial colonization on enamel in situ
    C Hannig
    Department of Operative Dentistry and Periodontology, University of Freiburg, Hugstetter Street 55, D 79106 Freiburg, Germany
    Arch Oral Biol 52:1048-56. 2007
    ..The aim of this in situ study was to visualize and to quantify these bacteria...
  44. pmc Community and gene composition of a human dental plaque microbiota obtained by metagenomic sequencing
    G Xie
    Oralgen Database, Genome Science Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Mol Oral Microbiol 25:391-405. 2010
    Human dental plaque is a complex microbial community containing an estimated 700 to 19,000 species/phylotypes...
  45. ncbi Biochemical composition and cariogenicity of dental plaque formed in the presence of sucrose or glucose and fructose
    J A Cury
    Faculty of Dentistry of Piracicaba, State University of Campinas, SP, Brazil
    Caries Res 34:491-7. 2000
    The composition of dental plaque formed in the presence of sucrose or glucose and fructose and its relation to cariogenicity was evaluated. Twelve adult volunteers took part in this crossover study done in three phases of 28 days each...
  46. ncbi An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses
    S Shapiro
    Institute for Oral Microbiology and General Immunology, Center for Dentistry, Oral Medicine, and Maxillofacial Surgery, University of Zurich, Switzerland
    Caries Res 36:93-100. 2002
    ..This polyspecies biofilm model can be a valuable tool for preclinical testing of antiplaque formulations, particularly during the product development stage...
  47. pmc The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms
    C R Fontana
    Applied Molecular Photomedicine Laboratory, The Forsyth Institute, Boston, MA 02115, USA
    J Periodontal Res 44:751-9. 2009
    ..Bacteria located within dense biofilms, such as those encountered in dental plaque, have been found to be relatively resistant to antimicrobial therapy...
  48. ncbi Plasminogen binding by oral streptococci from dental plaque and inflammatory lesions
    Bertil Kinnby
    Department of Oral Biology, Malmo University, S 20506 Malmö, Sweden
    Microbiology 154:924-31. 2008
    ..to examine the characteristics of plasminogen binding by six clinical isolates of oral streptococci from both dental plaque and inflammatory lesions...
  49. pmc Coaggregation-mediated interactions of streptococci and actinomyces detected in initial human dental plaque
    Robert J Palmer
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
    J Bacteriol 185:3400-9. 2003
    ..Further, these results demonstrate the spatiotemporal development and prevalence of mixed-species communities in early dental plaque.
  50. ncbi Comparison of microbial cultivation and a commercial PCR based method for detection of periodontopathogenic species in subgingival plaque samples
    Sigrun Eick
    Department of Microbiological Microbiology, University Hospital of Jena, Germany
    J Clin Periodontol 29:638-44. 2002
    ..The purpose of this study was to validate the commercially available micro-Dent(R) test which employs probes for A. actinomycetemcomitans, P. gingivalis, P. intermedia, B. forsythus and T. denticola...
  51. ncbi Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease
    James D Beck
    Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Periodontol 76:2089-100. 2005
    ..Principal component analyses illustrate the complexity of the interactions among risk factors, exposures, and outcomes. These analyses provide an initial clustering that describes and suggests the presence of specific syndromes...
  52. ncbi Validation of an in vitro biofilm model of supragingival plaque
    B Guggenheim
    Institute for Oral Microbiology and General Immunology, Center for Dentistry, Oral Medicine, and Maxillofacial Surgery, University of Zurich, Switzerland
    J Dent Res 80:363-70. 2001
    ..This biofilm model should prove very useful for pre-clinical testing of prospective anti-plaque agents at clinically relevant concentrations...
  53. pmc Clonal analysis of the microbiota of severe early childhood caries
    E Kanasi
    Department of Molecular Genetics, The Forsyth Institute, Boston, MA 02115, USA
    Caries Res 44:485-97. 2010
    ..Severe early childhood caries is a microbial infection that severely compromises the dentition of young children. The aim of this study was to characterize the microbiota of severe early childhood caries...
  54. ncbi Architecture of intact natural human plaque biofilms studied by confocal laser scanning microscopy
    S R Wood
    Division of Oral Biology, Leeds Dental Institute, University of Leeds, United Kingdom
    J Dent Res 79:21-7. 2000
    ..In this study, we used an in situ device for the in vivo generation of intact dental plaque biofilms on natural tooth surfaces in human subjects...
  55. ncbi Strain-related acid production by oral streptococci
    J J de Soet
    Oral Microbiology Section, Department of Oral Biology, Academic Centre for Dentistry, Amsterdam, The Netherlands
    Caries Res 34:486-90. 2000
    ..capability at different pH levels of 47 streptococcal strains, representing 9 species, isolated from human dental plaque. The bacteria were grown until mid log-phase under anaerobic conditions and acid production was measured in a ..
  56. pmc Multispecies communities: interspecies interactions influence growth on saliva as sole nutritional source
    Paul E Kolenbrander
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Int J Oral Sci 3:49-54. 2011
    Human oral bacteria live in multispecies communities in the biofilm called dental plaque. This review focuses on the interactions of seven species and the ability of each species individually and together with other species to grow on ..
  57. pmc Genetic relationships between respiratory pathogens isolated from dental plaque and bronchoalveolar lavage fluid from patients in the intensive care unit undergoing mechanical ventilation
    Seok Mo Heo
    Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA
    Clin Infect Dis 47:1562-70. 2008
    ..Recent studies suggest that dental plaque biofilms serve as a reservoir for respiratory pathogens...
  58. ncbi Conofocal microscopy study of undisturbed and chlorhexidine-treated dental biofilm
    E Zaura-Arite
    Department of Cariology/Endodontology/Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA, The Netherlands
    J Dent Res 80:1436-40. 2001
    ..staining of plaque smears are the most commonly used methods for evaluating the effects of antimicrobials on dental plaque. The visualization of the antimicrobial action on oral biofilm present on the substrate surface (in situ) ..
  59. ncbi Dental plaque as a microbial biofilm
    P D Marsh
    Leeds Dental Institute and Health Protection Agency, Porton Down, Salisbury, UK
    Caries Res 38:204-11. 2004
    New technologies have provided novel insights into how dental plaque functions as a biofilm. Confocal microscopy has confirmed that plaque has an open architecture similar to other biofilms, with channels and voids...
  60. ncbi The numerous microbial species in oral biofilms: how could antibacterial therapy be effective?
    J M Ten Cate
    Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands
    Adv Dent Res 24:108-11. 2012
    ..This article addresses some of the questions that can be raised and serves to identify research opportunities and needs to leverage the prevention of oral diseases through novel antimicrobial strategies...
  61. ncbi Dental plaque biofilm in oral health and disease
    Chaminda Jayampath Seneviratne
    Department of Oral BioSciences, The University of Hong Kong, Hong Kong, People s Republic of China
    Chin J Dent Res 14:87-94. 2011
    b>Dental plaque is an archetypical biofilm composed of a complex microbial community. It is the aetiological agent for major dental diseases such as dental caries and periodontal disease...
  62. ncbi A fluorescence assay to determine the viable biomass of microcosm dental plaque biofilms
    Sara K Filoche
    Dental Research Group, Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Mein Street, 6242, Wellington, New Zealand
    J Microbiol Methods 69:489-96. 2007
    b>Dental plaque bacteria form complex and robust cell aggregates which cannot be counted accurately using epifluorescence microscopy. This causes a significant problem for quantifying their viability...
  63. ncbi Relationship among dental plaque composition, daily sugar exposure and caries in the primary dentition
    M Nobre dos Santos
    Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    Caries Res 36:347-52. 2002
    The relationship among daily sugar exposure, dental plaque composition and caries patterns in the primary dentition is not known...
  64. pmc Effect of quaternary ammonium and silver nanoparticle-containing adhesives on dentin bond strength and dental plaque microcosm biofilms
    Ke Zhang
    Biomaterials and Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA
    Dent Mater 28:842-52. 2012
    ....
  65. ncbi Molecular analysis of bacteria in periodontitis: evaluation of clone libraries, novel phylotypes and putative pathogens
    Gerhard Hutter
    Institute for Hygiene, University of Wurzburg, Germany
    Microbiology 149:67-75. 2003
    ....
  66. pmc Endotoxemia and the host systemic response during experimental gingivitis
    Vivian Y Wahaidi
    Department of Periodontics and Allied Dental Programs, Indiana University School of Dentistry, Indianapolis, IN, USA
    J Clin Periodontol 38:412-7. 2011
    ..To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model...
  67. pmc Dental plaque, preventive care, and tooth brushing associated with dental caries in primary teeth in schoolchildren ages 6-9 years of Leon, Nicaragua
    Miriam del Socorro Herrera
    Faculty of Dentistry, National Autonomous University of Nicaragua, Leon, Nicaragua
    Med Sci Monit 19:1019-26. 2013
    ..Our study aimed to evaluate the effect of various risk indicators for dental caries on primary teeth of Nicaraguan children (from Leon, Nicaragua) ages 6 to 9, using the negative binomial regression model...
  68. ncbi Bacteriostatic effect of Piper betle and Psidium guajava extracts on dental plaque bacteria
    A R Fathilah
    Department of Oral Biology, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Pak J Biol Sci 12:518-21. 2009
    In this study, the bacteriostatic effect of Piper betle and Psidium guajava extracts on selected early dental plaque bacteria was investigated based on changes in the doubling time (g) and specific growth rates (micro)...
  69. ncbi Quantitative real-time polymerase chain reaction for Streptococcus mutans and Streptococcus sobrinus in dental plaque samples and its association with early childhood caries
    Eun Jung Choi
    Department of Pediatric Dentistry, School of Dentistry, Seoul National University, Seoul, South Korea
    Int J Paediatr Dent 19:141-7. 2009
    ..Recently, quantitative real-time polymerase chain reaction (qRT-PCR) has been used for rapid and accurate quantification of these bacterial species...
  70. ncbi The interleukin-10 promoter haplotype ATA is a putative risk factor for aggressive periodontitis
    S Reichert
    University School of Dental Medicine, Department of Operative Dentistry and Periodontology, Martin Luther University Hall Wittenberg, Halle Saale, Germany
    J Periodontal Res 43:40-7. 2008
    ....
  71. ncbi Quantitative detection of Porphyromonas gingivalis fimA genotypes in dental plaque
    Jan R van der Ploeg
    Institute for Oral Biology, Section for Oral Microbiology and General Immunology, Center for Dental, Oral Medicine and Maxillofacial Surgery, University of Zurich, Plattenstrasse 11, CH 8028 Zurich, Switzerland
    FEMS Microbiol Lett 232:31-7. 2004
    ..Genotypes I, III and V were of much lower prevalence and cell densities of the latter two remained sparse. Our results suggest marked differences among the fimA genotypes' ability to colonize host sites with high cell numbers...
  72. ncbi A method for the quantitative site-specific study of the biochemistry within dental plaque biofilms formed in vivo
    C Robinson
    Division of Oral Biology, Leeds Dental Institute, UK
    Caries Res 31:194-200. 1997
    ..been shown to vary with plaque depth and in vitro short-term exposure to radiolabelled components may be carried out, permitting important conclusions to be drawn regarding the site-specific composition and dynamics of dental plaque.
  73. ncbi Gingival changes during pregnancy: II. Influence of hormonal variations on the subgingival biofilm
    Ana Carrillo-de-Albornoz
    Department of Periodontology, School of Dentistry, Complutense University of Madrid, Spain
    J Clin Periodontol 37:230-40. 2010
    ..To determine whether the exacerbated gingival inflammation that develops in pregnant women is related to a change in the subgingival biofilm induced by the increase in hormone levels during pregnancy...
  74. pmc Acid production in dental plaque after exposure to probiotic bacteria
    Mette K Keller
    Department of Odontology, Section of Cariology, Endodontics, Pediatric Dentistry and Clinical Genetics, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    BMC Oral Health 12:44. 2012
    ..One possible side effect could be an increased acidogenicity in dental plaque. The aim of this study was to investigate the effect of probiotic lactobacilli on plaque lactic acid (LA) ..
  75. ncbi The predominant microflora of nursing caries lesions
    S Marchant
    Department of Oral Microbiology, Guy's, King's and St Thomas' Dental Institute, London, England
    Caries Res 35:397-406. 2001
    ....
  76. ncbi Clustering of subgingival microbial species in adolescents with periodontitis
    Rodrigo Lopez
    Department of Periodontology, Faculty of Health Sciences, Aarhus University, Denmark
    Eur J Oral Sci 119:141-50. 2011
    ..These findings confirm the occurrence of clustering of subgingival bacteria according to case status also among young individuals...
  77. ncbi Genome-genome interactions: bacterial communities in initial dental plaque
    Paul E Kolenbrander
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20902, USA
    Trends Microbiol 13:11-5. 2005
    ..We propose that dental plaque communities originate as a result of intimate interactions between cells (genomes) of different species and ..
  78. ncbi Serum levels of cytokines in subjects with generalized chronic and aggressive periodontitis before and after non-surgical periodontal therapy: a pilot study
    Poliana Mendes Duarte
    Dental Research Division, Department of Periodontics, Guarulhos University, Guarulhos, Sao Paulo, Brazil
    J Periodontol 81:1056-63. 2010
    ....
  79. ncbi Periodontal microbiota in patients with coronary artery disease measured by real-time polymerase chain reaction: a case-control study
    Claudia Nonnenmacher
    Institute of Medical Microbiology and Hygiene, Philipps University Marburg, Marburg, Germany
    J Periodontol 78:1724-30. 2007
    ..This case-control study aimed at studying the relationship between periodontal disease and coronary artery disease (CAD) based on clinical and periodontal microbiologic parameters...
  80. ncbi Quantitative detection of periodontal pathogens using real-time polymerase chain reaction with TaqMan probes
    M Kuboniwa
    Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    Oral Microbiol Immunol 19:168-76. 2004
    ..These results suggest that the present real-time PCR method with the designed probe/primer sets enabled sensitive detection of the six periodontal bacteria, and may also assist future microbial studies of periodontal diseases...
  81. ncbi Measuring plaque in clinical trials: index or weight?
    G I McCracken
    School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Clin Periodontol 33:172-6. 2006
    ..To explore the possibility of using plaque weight rather than plaque index as a more objective, clinical outcome measure in periodontal clinical trials...
  82. ncbi Glucan-binding proteins of the oral streptococci
    J A Banas
    Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA
    Crit Rev Oral Biol Med 14:89-99. 2003
    ..Future studies will greatly advance the understanding of the distribution, function, and regulation of the GBPs and place into perspective the facets of their contributions to the biology of the oral streptococci...
  83. ncbi Effects of mouthrinses with triclosan, zinc ions, copolymer, and sodium lauryl sulphate combined with fluoride on acid formation by dental plaque in vivo
    Elin Giertsen
    Department of Odontology Cariology, Faculty of Dentistry, University of Bergen, Arstadveien 17, NO 5009 Bergen, Norway
    Caries Res 38:430-5. 2004
    ..Neither triclosan incorporated into a mouthrinse containing SLS plus fluoride, nor the addition of zinc ions or copolymer affected acid formation by dental plaque in vivo.
  84. ncbi Quantitative real-time PCR using TaqMan and SYBR Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, tetQ gene and total bacteria
    Hiroshi Maeda
    Department of Patho physiology, Division of Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    FEMS Immunol Med Microbiol 39:81-6. 2003
    Accurate quantification of bacterial species in dental plaque is needed for microbiological diagnosis of periodontal diseases...
  85. ncbi Effects of intensity-modulated radiotherapy on human oral microflora
    Zi yang Shao
    Division of Radiation Oncology, Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China
    J Radiat Res 52:834-9. 2011
    ..Pooled dental plaque samples were collected during the radiation treatment from patients receiving IMRT (n = 13) and CRT (n = 12)...
  86. ncbi Polymerase chain reaction-based denaturing gradient gel electrophoresis in the evaluation of oral microbiota
    Y Li
    Department of Basic Science and Craniofacial Biology, College of Dentistry, New York University, New York, NY 10010, USA
    Oral Microbiol Immunol 21:333-9. 2006
    ..However, not all microbes in saliva or dental plaque can be cultivated...
  87. pmc Effects of triclosan-containing rinse on the dynamics and antimicrobial susceptibility of in vitro plaque ecosystems
    Andrew J McBain
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, United Kingdom
    Antimicrob Agents Chemother 47:3531-8. 2003
    b>Dental plaque microcosms were established under a feast-famine regimen within constant-depth film fermentors and exposed four times daily postfeeding to a triclosan (TR)-containing rinse (dentifrice) (TRD)...
  88. ncbi Strategies to enhance the biological effects of fluoride on dental biofilms
    H Koo
    Eastman Department of Dentistry and Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Adv Dent Res 20:17-21. 2008
  89. ncbi Reversal of primary root caries lesions after daily intake of milk supplemented with fluoride and probiotic lactobacilli in older adults
    Lars G Petersson
    Department of Community and Preventive Dentistry, Maxillofacial Unit, County Hospital, Halmstad, Sweden
    Acta Odontol Scand 69:321-7. 2011
    ..To evaluate the effect of milk supplemented with fluoride and/or probiotic bacteria on primary root caries lesions (PRCL) in older adults...
  90. ncbi Prevention. Part 4: Toothbrushing: what advice should be given to patients?
    R M Davies
    Dental Health Unit, Manchester Science Park, Lloyd Street North, Manchester M15 6SH, UK
    Br Dent J 195:135-41. 2003
  91. ncbi Salivary parameters of relevance for assessing caries activity in individuals and populations
    J Tenovuo
    Turku Immunology Centre, University of Turku, Finland
    Community Dent Oral Epidemiol 25:82-6. 1997
    ..Since the decisive processes in caries attack occur within or under the dental plaque, the buffering effect of saliva is limited and obviously more important to screen for erosion-than caries-..
  92. ncbi The effect of Piper betle and Psidium guajava extracts on the cell-surface hydrophobicity of selected early settlers of dental plaque
    Fathilah Abdul Razak
    Department of Oral Biology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
    J Oral Sci 48:71-5. 2006
    The adhesion of early settlers of dental plaque to the tooth surface has a role in the initiation of the development of dental plaque...
  93. ncbi Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1)
    John Hicks
    Department of Pathology, Texas Children s Hospital, Baylor College of Medicine, Houston Tx 77030 2313, USA
    J Clin Pediatr Dent 28:47-52. 2003
    ..The process of dental caries is dependent upon biological factors that are present within the saliva and dental plaque. There are many different agents within saliva and plaque that serve to protect the tooth surface against ..
  94. ncbi Microbiological profiles in saliva and supragingival plaque from caries-active adolescents before and after a short-term daily intake of milk supplemented with probiotic bacteria - a pilot study
    Michala Oron Lexner
    University of Copenhagen, Copenhagen, Denmark
    Oral Health Prev Dent 8:383-8. 2010
    ....
  95. ncbi Artificial mouth model systems and their contribution to caries research: a review
    Gaoyan Tang
    Oral Biosciences, The Prince Philip Dental Hospital, 34 Hospital Road, The University of Hong Kong, Hong Kong, People s Republic of China
    J Dent 31:161-71. 2003
    ..carious process to the present designs that evaluate growth, pathogenicity, metabolism and mineralization of dental plaque under highly controlled conditions...
  96. ncbi Dental plaque-induced gingival diseases
    A Mariotti
    Ohio State University School of Dentistry, Columbus, USA
    Ann Periodontol 4:7-19. 1999
    ..The classification of gingival diseases that depends on dental plaque to initiate the disease process(es) has been categorized into two groups...
  97. ncbi Microbial complexes in supragingival plaque
    A D Haffajee
    Department of Periodontology, The Forsyth Institute, Boston, MA 02115, USA
    Oral Microbiol Immunol 23:196-205. 2008
    ..To examine microbial communities in supragingival biofilm samples...
  98. ncbi Plaque inhibition of two commercially available chlorhexidine mouthrinses
    D A C Van Strydonck
    Department of Periodontology, Academic Centre for Dentistry, Amsterdam, The Netherlands
    J Clin Periodontol 32:305-9. 2005
    ..12% CHX non-alcohol base with 0.05% cetyl pyridinium chloride (Cpc) versus 0.2% CHX alcohol base)...
  99. pmc Increased atherogenesis during Streptococcus mutans infection in ApoE-null mice
    L Kesavalu
    Department of Periodontology, University of Florida, Gainesville, FL 32610 0424, USA
    J Dent Res 91:255-60. 2012
    ..In conclusion, S. mutans infection accelerated plaque growth, macrophage invasion, and TLR4 expression after angioplasty. S. mutans may also be associated with atherosclerotic plaque growth in non-injured arteries...
  100. ncbi The quantification of dental plaque using an image analysis system: reliability and validation
    R N Smith
    Department of Child Dental Health, University of Sheffield, School of Clinical Dentistry, Claremont Crescent, Sheffield, S10 2TA, UK
    J Clin Periodontol 28:1158-62. 2001
    Established clinical indices used to measure dental plaque have limitations...
  101. ncbi Action of agents on glucosyltransferases from Streptococcus mutans in solution and adsorbed to experimental pellicle
    D Wunder
    University of Rochester, Center for Oral Biology, NY 14642, USA
    Arch Oral Biol 44:203-14. 1999
    ..These data indicate that the nature of the inhibitor is important, and also whether the Gtf enzyme is in solution or adsorbed to saliva-coated hydroxylapatite...

Research Grants66

  1. Biology and Drug Resistance of Candida Biofilms
    Mahmoud Ghannoum; Fiscal Year: 2005
    ..The etiology of denture stomatitis involves dental plaque. Dental plaque consists of a complex biofilm of bacteria and yeasts, predominantly Candida albicans. C...
  2. Clinical , Mechanical and Chemical Evaluation of Amalgam and ART Restorations
    Lilliam Marie Pinzon; Fiscal Year: 2013
    ..Dental caries occurs when bacterial dental plaque combines with consumed, fermentable carbohydrates...
  3. Contribution of the Streptococcus mutans cid and lrg Murein Hydrolase Regulator H
    KELLY CHRISTINE RICE; Fiscal Year: 2010
    ..autolysis in the oral streptococci, and how these processes contribute to their ability to grow and survive in dental plaque as well as their ability to colonize heart valves during endocarditis...
  4. Expression of clp genes in Streptococcus mutans
    Indranil Biswas; Fiscal Year: 2013
    ..organism colonizes the oral cavity by forming diverse, multispecies biofilms on the tooth surface, known as dental plaque. This pathogen has developed multiple mechanisms to adapt and to flourish in the hostile environment of the ..
  5. The effect of inter-species interactions on the virulence of Streptococcus mutans
    Bing yan Wang; Fiscal Year: 2009
    ..mutans with oral bacteria in the dental plaque biofilm. We hypothesize that it is not merely colonization by S...
  6. Functional Amyloid Formation in Streptococcus mutans
    L Jeannine Brady; Fiscal Year: 2013
    ..Amyloid is present in human dental plaque and is produced by both lab strains and clinical isolates...
  7. Combinatorial Imaging of the Oral Microbiome
    Floyd E Dewhirst; Fiscal Year: 2010
    ..b>Dental plaque is a biofilm constructed and inhabited by microbes, and the oral microbial community is involved in the ..
  8. Novel aryl-rhodanine inhibitors of Streptococcus mutans biofilms
    TIMOTHY J OPPERMAN; Fiscal Year: 2012
    ..b>Dental plaque, a biofilm community growing on the tooth surface, can harbor organisms that cause dental caries...
  9. Daily Mouth Care to Prevent Pneumonia in Nursing Homes: A Systems-Level Approach
    Sheryl Zimmerman; Fiscal Year: 2013
    ..and attitudes related to mouth care;improved tooth brushing and flossing;and most importantly, reduced dental plaque and gingivitis that harbor the bacteria that can cause pneumonia...
  10. Development of targeted photodynamic therapy for treatment of dental caries
    Randal Eckert; Fiscal Year: 2010
    ..The current antimicrobial strategies used to treat dental caries consist primarily of mechanical removal of dental plaque or a generalized killing of oral bacteria with broad-spectrum antimicrobial compounds...
  11. Oxidative Stress in Oral Streptococci
    Robert E Marquis; Fiscal Year: 2010
    ..damage to oral streptococci and to use this information to develop effective antimicrobial for control of Dental plaque pathogenicity, primarily related to Dental caries. The Specific Aims of the project are the following...
  12. Making a quantum leap in plaque research with modern sciences
    Wenyuan Shi; Fiscal Year: 2013
    ..This will require a detailed picture of dental plaque organisms, their metabolic activities and interactions...
  13. A novel strategy in antimicrobial drug discovery against Porphyromonas gingivalis
    VICTORIA NANETTE STONE; Fiscal Year: 2013
    ..and initiates with the establishment of a poly-microbial complex on the tooth surface more commonly known as dental plaque. Coupled with various immunological factors bacterial pathogens can trigger the deterioration of tooth ..
  14. The competence regulon in Streptococcus mutans biofilms
    Dennis G Cvitkovitch; Fiscal Year: 2011
    Streptococcus mutans resides in the biofilm of dental plaque where it produces acid from dietary carbohydrate to cause caries. S...
  15. Identification of anti-inflammatory compounds from chocolate for the treatment of
    Andy McShea; Fiscal Year: 2012
    ..extracts of cocoa bean husks and chocolate can contain activity that is either anti-inflammatory and/or dental plaque inhibiting...
  16. Probing oral pathogen interactions in picoliter-scale enclosures
    AIMEE KATHERINE WESSEL; Fiscal Year: 2013
    ..by multiple environmental factors, such as population size and flow of saliva or crevicular fluid across dental plaque, however it is not yet fully understood which factors regulate QS...
  17. Molecular Assembly on the Cell Surface of Actinomyces
    Hung Ton-That; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dental plaque represents one of the most complex microbial communities or biofilms known to afflict man...
  18. Microfluidic devices for studying genetic competence in Streptococcus mutans
    STEPHEN JAMES HAGEN; Fiscal Year: 2010
    ..Biofilms can pose significant threats to human health. In oral biofilms (i.e. dental plaque), for example, the metabolic activity of acid-tolerant bacteria such as Streptococcus mutans generates acid ..
  19. Gastro-intestinal microbes degrading dietary gluten
    EVA JOSEPHINE HELMERHORST; Fiscal Year: 2013
    ..The specific aims are: (1) To identify gluten-degrading microorganism(s) in dental plaque and fecal specimens;(2) To define protease cleavage site specificity and assess the abolishment of immunogenic ..
  20. Nanoparticle-based Antimicrobial Photochemotherapy in Biofilms
    NIKOLAOS SOUKOS; Fiscal Year: 2010
    ..way to enhance the penetration and effectiveness of photoactive compounds (or photosensitizers) in human dental plaque for prevention, control and/or treatment of periodontitis...
  21. Oral care treatment for mobility-impaired patients
    Sheldon E Broedel; Fiscal Year: 2011
    ..However, for mobility-impaired patients, there are no effective alternative options for preventing or removing dental plaque. Consequently, dental caries in approximately 26 million geriatric patients has grown to epidemic proportions ..
  22. Oxygen and Streptococcus mutans Virulence
    Robert A Burne; Fiscal Year: 2010
    ..studies will lead directly to a better understanding of the behavior of this pathogen in immature and mature dental plaque. This line of investigation has already discovered, and will continue to disclose, novel pathways that may ..
  23. Unique Anti-microbial Rinse to Reduce Oral Inflammation
    Charles J Gauntt; Fiscal Year: 2012
    ..It is well established that periodontal disease results from microorganisms in dental plaque biofilm...
  24. Proton Sponge Adhesives, Interfacial Milieu: Molecular Structure-Mechanics
    Paulette Spencer; Fiscal Year: 2013
    ..e., a biofilm. Dental plaque biofilm cannot be eliminated, but the pathogenic impact of the biofilm at the gingival margin could be reduced ..
  25. Developing genetic transformation system in veillonellae
    Fengxia Qi; Fiscal Year: 2012
    ..Holistic or probiotic approaches based on understanding the ecology of the microorganisms in the dental plaque could provide viable options for disease prevention and management...
  26. GENE REGULATION AND PHYSIOLOGY OF STREPTOCOCCUS MUTANS
    Robert A Burne; Fiscal Year: 2013
    ..be the single most important environmental factor affecting the composition and pathogenic potential of human dental plaque. The goals of this research are to provide a comprehensive understanding of the molecular basis for how the ..
  27. Investigation of the role of AI-2 in the development of dental plaque biofilms
    ALEXANDER HAMMOND RICKARD; Fiscal Year: 2010
    b>Dental plaque is an example of a bacterial multi-species biofilm community...
  28. Modulation of Oral Biofilm Development by Secretory IgA and IgA1 Proteases
    Thomas A Brown; Fiscal Year: 2010
    ..b>Dental plaque is a complex biofilm on the tooth surface that is subject to fluctuations in environmental factors in the oral ..
  29. Oral H. pylori Prevalence in Intellectually/Developmentally Disabled Adults
    Catherine Binkley; Fiscal Year: 2009
    ..Numerous studies have identified H. pylori in dental plaque, an environment that is relatively resistant to systemic antibiotics. Systemic antibiotics are used to treat H...
  30. AI-2-dependent quorum sensing in Aggregatibacter actinomycetemcomitans
    ELIZABETH ANN NOVAK; Fiscal Year: 2012
    b>Dental plaque is a complex oral biofilm comprised of a diverse microbial community, which necessitates that bacteria coordinate their behavior and function based on the environment and other organisms in the biofilm...
  31. Distribution correlation of P. gingivalis and S. cristatus in dental plaque
    Hua Xie; Fiscal Year: 2013
    ..Microbial samples from dental plaque will be collected. The prevalence of S. cristatus and P...
  32. AMYLASE BINDING STREPTOCOCCI, DENTAL PLAQUE AND CARIES
    FRANK ANDREW SCANNAPIECO; Fiscal Year: 2011
    ..commensal oral streptococci that are early colonizers of the salivacoated tooth and numerous in supragingival dental plaque. Interestingly, amylase-binding streptococcal (ABS) colonization is restricted to hosts with detectable ..
  33. Amylase binding and gene expression in S. gordonii
    FRANK ANDREW SCANNAPIECO; Fiscal Year: 2013
    ..commensal oral streptococci that are early colonizers of the saliva-coated tooth and numerous in supragingival dental plaque. Amylase-binding streptococci (ABS) colonize only hosts with detectable salivary amylase activity suggesting ..
  34. Analysis for Incomplete Data in Oral Health/Ventilator-Associated Pneumonia Study
    Jihnhee Yu; Fiscal Year: 2012
    ..Outcome variables include oral colonization by target micro-organisms, the dental Plaque Index score and diagnostic variables for pneumonia...
  35. Spatial Organization of the Oral Microbiome
    Floyd E Dewhirst; Fiscal Year: 2013
    ..two laboratories, supported by an ARRA Challenge Grant, applied the CLASI strategy to the analysis of human dental plaque, a microbial biofilm, and led to a "proof-of-principle" publication that characterized the proximity ..
  36. CLONING AND PURIFICATION OF A VEILLONELLA ADHESIN
    Christopher Hughes; Fiscal Year: 1993
    Adherence of one bacterial cell type to another has been proposed as an important mechanism for dental plaque formation...
  37. 5th ASM Conference on Biofilms
    HAVVA FITNAT YILDIZ; Fiscal Year: 2010
    ..ways, ranging all the way from global cycling to wastewater treatment to fighting infected implants and dental plaque. This diversity is reflected in the multidisciplinary approach that is required to understand and control ..
  38. Developing acid-activated antimicrobial peptides to control dental caries
    Maxwell Anderson; Fiscal Year: 2009
    ..The current anti-microbial strategies used to treat dental caries consist primarily of mechanical removal of dental plaque or a generalized killing of oral bacteria with broad-spectrum anti-microbial compounds...
  39. STRUCTURE OF THE RECEPTORS FOR ORAL BACTERIAL ADHESINS
    C Bush; Fiscal Year: 1991
    ..The molecular basis of the interbacterial adherence leading to the formation of dental plaque and subsequent initiation of gingivitis and periodontal disease will be investigated...
  40. PERIODONTAL DISEASES: B CELLS ACTIVATED BY MITOGENS
    JAMES CLAGETT; Fiscal Year: 1980
    ..data from our laboratory suggest that nonspecific polyclonal activation of host B-cells by substances from the dental plaque bacterium, Actinomyces viscosus (AVIS) may play an important role in the recruitment, maturation and ..
  41. WHOLE GENOME SHOTGUN SEQUENCING OF STREPTOCOCCUS MITIS
    Herve Tettelin; Fiscal Year: 2001
    ..strain of Streptococcus mitis, the predominant pioneer colonizer of tooth surfaces, and thus an initiator of dental plaque formation relevant to caries and periodontal disease...
  42. IN VIVO STUDIES OF SALIVA ANTIMICROBIAL PROTEINS
    JOEL RUDNEY; Fiscal Year: 2001
    Salivary proteins may influence dental plaque through mechanisms such as cell killing, bacterial aggregation, and adherence to pellicle. In vitro studies have identified saliva proteins involved in each process...
  43. STREPTOCOCCUS SANGUIS MICROBIAL GENOME PROJECT
    FRANCIS MACRINA; Fiscal Year: 2002
    ..a tether for the attachment of a variety of other oral microorganisms which colonize the tooth surface, form dental plaque, and contribute to the etiology of both caries and periodontal disease. Furthermore, S...
  44. Validation of chair-side biochemical screening instruments for dental caries
    EVANGELIA MOROU-BERMUDEZ; Fiscal Year: 2012
    ..HYPOTHESIS: Based on the CRP model, we hypothesize that measuring the ability of dental plaque and/or saliva to generate alkali from urea, or other salivary substrates, together with the ability to ..
  45. Intra-Oral Biofilm Formation
    Sigmund Socransky; Fiscal Year: 2004
    ..While much has been learned about mature Dental plaque, little is known about the sequence of changes in microbial species that occurs during supra or subgingival ..
  46. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Removing dental plaque may thus reduce recolonization following antibacterial rinse...
  47. GENETICS OF ANTIBODIES TO PERIODONTAL PATHOGENS
    JEROME HABER; Fiscal Year: 1990
    ..These diseases are caused by dental plaque associated microorganisms, which colonize the tooth surface and gingival sulcus...
  48. Alkali production in human dental plaque and saliva as predictor of caries risk
    VALERIA GORDAN; Fiscal Year: 2009
    ..AD and urease activities will be measured in dental plaque and saliva samples from caries free subjects, caries experienced subjects, and subjects with at least 4 teeth ..
  49. DENTAL PLAQUE REDUCTION BY GENETIC ENGINEERING
    ROBERT QUIVEY; Fiscal Year: 1993
    b>Dental plaque constitutes an ecological niche, activities of which are highly correlated with the onset and development of dental caries. Insoluble glucan, termed mutan, provides the molecular framework around which plaque accumulates...
  50. Specificity of Streptococcus mutans sugar transporters
    Dragana Ajdic; Fiscal Year: 2009
    Sugar transport and metabolism by Streptococcus mutans is directly related to the onset and development dental plaque, leading to the formation of human dental caries (tooth decay). In S...
  51. CHILDHOOD IMMUNIZATION FOR DENTAL CARIES
    DEBRA TRANTOLO; Fiscal Year: 2000
    ..streptococci by providing binding sites for cariogenic mutans streptococci as well as changing the porosity of dental plaque. GTF from MS can induce an immune response that inhibits GTF catalytic activity, protect rodents from dental ..
  52. REGULATION OF STREPTOCOCCUS GORDONII GLUCOSYLTRANSFERASE
    M Vickerman; Fiscal Year: 1999
    ..Since S. gordonii cells and their products are present in early dental plaque, they act as a substratum for the attachment of other oral organisms, including potential pathogens, and ..
  53. Metagenomics of the Microbiome in Oral Health and Disease
    Karen E Nelson; Fiscal Year: 2013
    ..Dental caries has a well established link to discrete, but only partially characterized changes in the dental plaque microbiome...
  54. ASM Conference on Biofilms 2007
    Paul Stoodley; Fiscal Year: 2007
    ..ways, ranging all the way from global cycling to wastewater treatment to fighting infected implants and dental plaque. This diversity is reflected in the multidisciplinary approach that is required to understand and control ..
  55. LOW PH INDUCIBLE DNA REPAIR IN STREPTOCOCCUS MUTANS
    ROBERT QUIVEY; Fiscal Year: 2005
    ..is a primary mechanism that Streptococcus mutans employs to survive the low pH environments that can occur in dental plaque. As part of that adaptive ability, the organism increases production of an enzyme, known as an exonuclease, ..
  56. Stationary Phase Behavior in Oral Streptococci
    PATRICK PIGGOT; Fiscal Year: 2006
    ..We think that stationary-phase bacteria are critical to the behavior and survival of S. mutans in the Dental plaque biofilm, and hence to its role in Dental caries...
  57. Prevention and Treatment of Oral Biofilms and Related Oral Disease by Soluble Chi
    SHENDA BAKER; Fiscal Year: 2009
    ..for safe and effective, prophylactic and therapeutic treatments for controlling bacterial populations in dental plaque and treating periodontal disease...
  58. NEW SALICYLANILIDES FOR CONTROL OF ORAL DISEASE
    ROBERT COBURN; Fiscal Year: 1999
    ..However, many individuals, due to lack of ability of poor compliance, do not remove sufficient dental plaque to adequately control periodontal infections...
  59. Dental Plaque Accumulation as a Risk Factor for CHD
    Michael Kowolik; Fiscal Year: 2005
    ..This study will employ an acute disease model to determine whether dental plaque accumulation and the resultant gingivitis have systemic consequences with the potential to increase risk for ..
  60. GENOME ANALYSIS OF STREPTOCOCCUS GORDONII
    Steven Gill; Fiscal Year: 2001
    ..this project is to determine the complete genome sequence of Streptococcus gordonii, a pioneering colonizer of dental plaque and significant causative bacterium for infective endocarditis...
  61. MICROBIOLOGIC STUDIES OF HUMAN ORAL STREPTOCOCCI
    JOSEPH DIRIENZO; Fiscal Year: 2001
    b>Dental plaque is a complex biofilm characterized by a pioneer community that is dominated by streptococci. As plaque reaches its final climax community it acquires and increasingly more filamentous composition...
  62. LuxS-Mediated Quorum Sensing in Streptococcus mutans
    ZEZHANG WEN; Fiscal Year: 2004
    ..mutans lives primarily on the tooth surface at high cell-density in a high diversity ecosystem better known as dental plaque, the structure and composition of which is known to be largely influenced by such factors as the source and ..
  63. LYSIS OF CARIOGENIC BACTERIA BY PHAGE-ENCODED ENZYMES
    ALLAN DELISLE; Fiscal Year: 2002
    ..naeslundii (A. viscosus), an early colonizer of dental plaque, has long been believed to be involved in gingivitis and root surface (cementum) caries...
  64. CARIOGENIC POTENTIAL OF DENTAL PLAQUE FLUID
    HENRY MARGOLIS; Fiscal Year: 2001
    ..which influence the degree of saturation with respect to enamel mineral of the extracellular aqueous phase of dental plaque, plaque fluid...
  65. Salivary Amylase: Role in Dental Caries Pathogenesis
    Narayanan Ramasubbu; Fiscal Year: 2007
    ..in solution may result in bacterial clearance (protective) its presence in the enamel pellicle may facilitate Dental plaque formation (harmful)...
  66. Research-Grade Cranberry Product Development
    Cheryl Robinson; Fiscal Year: 2010
    ..in the prevention and treatment of urinary tract infections (UTIs) and other infections or conditions such as dental plaque. In addition, products will be used to examine bioavailability and interaction of cranberry with antibiotics...