dental enamel hypoplasia

Summary

Summary: A form of AMELOGENESIS IMPERFECTA characterized by incomplete formation of the dental enamel and transmitted as an X-linked or autosomal dominant trait. It is also associated with vitamin A, C, or D deficiency, infectious disease, prematurity, birth injury, Rh incompatibility, trauma, or local infection. Small grooves, pits, and fissures are seen in mild cases, deep horizontal rows of pits in severe cases, or absence of enamel in extreme cases. (Dorland, 27th ed)

Top Publications

  1. ncbi Prevalence and distribution of developmental enamel defects in primary dentition of Chinese children 3-5 years old
    Y Li
    School of Dentistry, University of Alabama at Birmingham 35294, USA
    Community Dent Oral Epidemiol 23:72-9. 1995
  2. ncbi Oral manifestations in 22q11 deletion syndrome
    G Klingberg
    Mun H Center, National Orofacial Resource Centre for Rare Disorders, Goteborg, Sweden
    Int J Paediatr Dent 12:14-23. 2002
  3. ncbi [The study on the clinical manifestation of developmental enamel defects in primary dentition]
    Shuguo Zheng
    Department of Pediatric Dentistry, School of Stomatology, Peking University, Beijing 100081, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 21:200-1, 204. 2003
  4. ncbi Nursing caries, linear hypoplasia, and nursing and weaning habits in Tanzanian infants
    M Matee
    Department of Microbiology, Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania
    Community Dent Oral Epidemiol 22:289-93. 1994
  5. ncbi Molar incisor hypomineralisation in Bosnia and Herzegovina: aetiology and clinical consequences in medium caries activity population
    A Muratbegovic
    Dept Preventive and Paediatric Dentistry, Faculty of Dentistry, University of Sarajevo, Bosnia and Herzegovina
    Eur Arch Paediatr Dent 8:189-94. 2007
  6. ncbi Comparison of enamel defects in the primary and permanent dentitions of children from a low-fluoride District in Australia
    W Kim Seow
    Professor and Director, Centre for Paediatric Dentistry Research and Training, School of Dentistry, University of Queensland, Brisbane, Australia
    Pediatr Dent 33:207-12. 2011
  7. ncbi Prenatal and neonatal risk factors for the development of enamel defects in low birth weight children
    M A Velló
    Department of Pediatric Dentistry, School of Dentistry, University of Valencia, Valencia, Spain
    Oral Dis 16:257-62. 2010
  8. ncbi Enamel defects and its relation to life course events in primary dentition of Brazilian children: a longitudinal study
    A M B Chaves
    Department of Paediatric Dentistry, Faculty of Dentistry of Pernambuco, Camaragibe, Brazil
    Community Dent Health 24:31-6. 2007
  9. pmc Prevalence of enamel defects in primary and permanent teeth in a group of schoolchildren from Granada (Spain)
    Maria Jesús Robles
    University of Granada, Campus de Cartuja, Colegio Maximo s n, Granada, Spain
    Med Oral Patol Oral Cir Bucal 18:e187-93. 2013
  10. ncbi Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis
    Adrianna Mostowska
    Department of Biochemistry and Molecular Biology, University of Medical Sciences in Poznan, Swiecickiego St 6, 60 781 Poznan, Poland
    J Hum Genet 51:262-6. 2006

Detail Information

Publications208 found, 100 shown here

  1. ncbi Prevalence and distribution of developmental enamel defects in primary dentition of Chinese children 3-5 years old
    Y Li
    School of Dentistry, University of Alabama at Birmingham 35294, USA
    Community Dent Oral Epidemiol 23:72-9. 1995
    ..05), and mean EDS (P < 0.05). Children born prematurely were shown to have four times more enamel lesions than children who were full term (P < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)..
  2. ncbi Oral manifestations in 22q11 deletion syndrome
    G Klingberg
    Mun H Center, National Orofacial Resource Centre for Rare Disorders, Goteborg, Sweden
    Int J Paediatr Dent 12:14-23. 2002
    ..The aims of this study were to investigate and describe oral manifestations in 22q11 deletion syndrome, and to relate the findings to medical conditions...
  3. ncbi [The study on the clinical manifestation of developmental enamel defects in primary dentition]
    Shuguo Zheng
    Department of Pediatric Dentistry, School of Stomatology, Peking University, Beijing 100081, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 21:200-1, 204. 2003
    ..To study the clinical manifestation and its pathogenesis of the developmental enamel defects in primary dentition of children with low birth weight and premature birth history...
  4. ncbi Nursing caries, linear hypoplasia, and nursing and weaning habits in Tanzanian infants
    M Matee
    Department of Microbiology, Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania
    Community Dent Oral Epidemiol 22:289-93. 1994
    ....
  5. ncbi Molar incisor hypomineralisation in Bosnia and Herzegovina: aetiology and clinical consequences in medium caries activity population
    A Muratbegovic
    Dept Preventive and Paediatric Dentistry, Faculty of Dentistry, University of Sarajevo, Bosnia and Herzegovina
    Eur Arch Paediatr Dent 8:189-94. 2007
    ..This was to establish the prevalence of MIH among 12-year-old children in Bosnia and Herzegovina, and to investigate its aetiological background and clinical consequences of MIH in a population with medium caries activity...
  6. ncbi Comparison of enamel defects in the primary and permanent dentitions of children from a low-fluoride District in Australia
    W Kim Seow
    Professor and Director, Centre for Paediatric Dentistry Research and Training, School of Dentistry, University of Queensland, Brisbane, Australia
    Pediatr Dent 33:207-12. 2011
    ..The purpose of this study was to compare developmental defects of enamel (DDE) in the primary and permanent dentitions of children from a low-fluoride district...
  7. ncbi Prenatal and neonatal risk factors for the development of enamel defects in low birth weight children
    M A Velló
    Department of Pediatric Dentistry, School of Dentistry, University of Valencia, Valencia, Spain
    Oral Dis 16:257-62. 2010
    ..To analyse the influence of several prenatal and neonatal risk factors in the development of enamel defects in low birth weight children...
  8. ncbi Enamel defects and its relation to life course events in primary dentition of Brazilian children: a longitudinal study
    A M B Chaves
    Department of Paediatric Dentistry, Faculty of Dentistry of Pernambuco, Camaragibe, Brazil
    Community Dent Health 24:31-6. 2007
    ..To evaluate the cumulative incidence of enamel defects (ED) and its correlation with life course events such as malnutrition and pre- and postnatal infections, in a cohort of children of low socioeconomic status...
  9. pmc Prevalence of enamel defects in primary and permanent teeth in a group of schoolchildren from Granada (Spain)
    Maria Jesús Robles
    University of Granada, Campus de Cartuja, Colegio Maximo s n, Granada, Spain
    Med Oral Patol Oral Cir Bucal 18:e187-93. 2013
    ..The purpose of this study was to determine and compare the prevalence and presentations of developmental defects of the enamel (DDE) in the primary and permanent dentitions of a group of healthy schoolchildren residing in Granada (Spain)...
  10. ncbi Axis inhibition protein 2 (AXIN2) polymorphisms may be a risk factor for selective tooth agenesis
    Adrianna Mostowska
    Department of Biochemistry and Molecular Biology, University of Medical Sciences in Poznan, Swiecickiego St 6, 60 781 Poznan, Poland
    J Hum Genet 51:262-6. 2006
    ..This alternation may negatively affect the splicing process and cellular concentration of AXIN2 protein. Our findings suggest that AXIN2 polymorphic variants may be associated with both hypodontia and oligodontia...
  11. ncbi A controlled study of risk factors for enamel hypoplasia in the permanent dentition
    D Ford
    Northside Specialist Centre, Alderley, Queensland, Australia
    Pediatr Dent 31:382-8. 2009
    ..The purpose of this study was to investigate risk factors for enamel hypoplasia (EH) and enamel opacity (EO) in the permanent teeth of healthy schoolchildren from a nonfluoridated community in Australia...
  12. ncbi Prevalence and Diagnosis of Molar-Incisor- Hypomineralisation (MIH): A systematic review
    B Jälevik
    Centre of Orthodontics and Paediatric Dentistry, S 581 85 Linkoping, Sweden
    Eur Arch Paediatr Dent 11:59-64. 2010
    ..This was to review the literature published, to point out shortcomings and to suggest areas in need of improvement concerning the diagnosis and prevalence of MIH...
  13. ncbi Prevalence of enamel hypoplasia and isolated opacities in the primary dentition
    R L Slayton
    Department of Pediatric Dentistry, University of Iowa, College of Dentistry, USA
    Pediatr Dent 23:32-6. 2001
    ..The purpose of this paper is to report the prevalence of enamel hypoplasia and isolated enamel opacities in a cohort of healthy, well-nourished children in Iowa...
  14. pmc Association between enamel hypoplasia and dental caries in primary second molars: a cohort study
    L Hong
    Department of Dental Public Health and Behavioral Science, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108 2784, USA
    Caries Res 43:345-53. 2009
    ..Enamel hypoplasia appears to be a significant risk factor for caries and should be considered in caries risk assessment...
  15. ncbi Enamel defects and dental caries in 9-year-old children living in fluoridated and nonfluoridated areas of Auckland, New Zealand
    Sathananthan Kanagaratnam
    Waitemata District Health Board, Auckland Regional Dental Service, Auckland, New Zealand
    Community Dent Oral Epidemiol 37:250-9. 2009
    ..This epidemiological study aims to investigate the developmental enamel defects and dental caries among 9-year-old children resident in fluoridated and nonfluoridated regions in Auckland, New Zealand...
  16. ncbi Association between developmental enamel defects in the primary and permanent dentitions
    A J Casanova-Rosado
    Faculty of Dentistry, Autonomous University of Campeche, Campeche, Mexico
    Eur J Paediatr Dent 12:155-8. 2011
    ..To determine if the presence of developmental enamel defects (DED) in the primary dentition is a risk indicator for the presence of DED in the permanent dentition in children with mixed dentition, as well as others factors...
  17. ncbi The relationship of enamel defects and caries: a cohort study
    A G R Targino
    Department of Clinical and Social Dentistry, Federal University of Paraiba, Joao Pessoa, Brazil
    Oral Dis 17:420-6. 2011
    ..Is there a relationship between enamel defects and early childhood caries?..
  18. ncbi Developmental enamel defects and their association with dental caries in preschoolers in Jeddah, Saudi Arabia
    Najat Farsi
    Department of Preventive Dental Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
    Oral Health Prev Dent 8:85-92. 2010
    ..The aim of the present study was to examine the prevalence, severity and association of developmental enamel defects (DED) and dental caries in a sample of 4- and 5-year-old children living in Jeddah, Saudi Arabia...
  19. ncbi Common dental conditions associated with dental erosion in schoolchildren in Australia
    Stauros Kazoullis
    School of Dentistry, University of Queensland, Brisbane, Australia
    Pediatr Dent 29:33-9. 2007
    ..The purpose of the investigation was to determine factors associated with dental erosion in a group of schoolchildren in Queensland, Australia...
  20. ncbi NF1 microduplication first clinical report: association with mild mental retardation, early onset of baldness and dental enamel hypoplasia?
    Bernard Grisart
    Centre de Genetique Humaine, Institut de Pathologie et de Génétique, Gosselies, Belgium
    Eur J Hum Genet 16:305-11. 2008
    ..Main phenotypic features are mental deficiency, early onset of baldness (15 years old), dental enamel hypoplasia and minor facial dysmorphism...
  21. ncbi Developmental defects of enamel in primary teeth: prevalence and associated factors
    Patrícia Corrêa-Faria
    Federal University of Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil
    Int J Paediatr Dent 23:173-9. 2013
    ..Studies on the prevalence of enamel defects in the primary dentition as a whole are scarce, as most investigations examine specific population groups...
  22. ncbi The prevalence of demarcated opacities in permanent first molars in a group of Swedish children
    B Jälevik
    Department of Pedodontics, Faculty of Odontology, Goteborg University, Sweden
    Acta Odontol Scand 59:255-60. 2001
    ..5% had severe defects, 5% had moderate defects, whereas 7% had only mildly hypomineralized teeth. In conclusion, hypomineralized first molars appeared to be common and require considerable treatment in the Swedish child population...
  23. ncbi Prevalence of enamel defects/fluorosis in fluoridated and non-fluoridated areas in Ireland
    J J Clarkson
    Department of Health, Dublin, Ireland
    Community Dent Oral Epidemiol 20:196-9. 1992
    ..The prevalence of enamel fluorosis/defects was similar in children living in fluoridated and non-fluoridated areas but the prevalence of diffuse opacities (DDE) was higher in the fluoridated areas...
  24. ncbi Prevalence of dental caries and enamel defects in Connecticut Head Start children
    Marilia J Montero
    Department of Pediatric Dentistry, University of Illinois, Chicago, IL, USA
    Pediatr Dent 25:235-9. 2003
    ..The aim of this study was to determine the prevalence of dental caries and enamel defects in a sample of predominantly African American and Hispanic children from an inner city Head Start program located in Connecticut...
  25. ncbi The influence of enamel defects on the development of early childhood caries in a population with low socioeconomic status: a longitudinal study
    A F B Oliveira
    Department of Morphology, Federal University of Paraiba, Joao Pessoa, Brazil
    Caries Res 40:296-302. 2006
    ..0001). Enamel defects are strongly associated with early childhood caries and, therefore, this correlation must be considered when focussing on low-socioeconomic communities...
  26. pmc Prevalence and socio-behavioral influence of early childhood caries, ECC, and feeding habits among 6-36 months old children in Uganda and Tanzania
    Ray Masumo
    Department of Clinical Dentistry, Community Dentistry, University of Bergen, Bergen, Norway
    BMC Oral Health 12:24. 2012
    ..Early childhood caries (ECC) is a serious problem that has remained unexplored in sub-Saharan Africa. This study aimed to identify possible socio-behavioral correlates of ECC focusing 6-36 months old children and their caretakers...
  27. pmc Prevalence of enamel defects and associated risk factors in both dentitions in preterm and full term born children
    Vanessa Resende Nogueira Cruvinel
    Department of Pediatric Dentistry, School of Dentistry, Catholic University of Brasilia, Brasilia, DF, Brazil
    J Appl Oral Sci 20:310-7. 2012
    ....
  28. ncbi An epidemiological comparison of Dean's index and the Developmental Defects of Enamel (DDE) index
    A Rizan Mohamed
    Ministry of Health, Brunei Darussalam
    J Public Health Dent 70:344-7. 2010
    ..To compare the Dean's and DDE indices in examining dental fluorosis and diffuse opacities...
  29. ncbi Breast-feeding and other mother-child factors associated with developmental enamel defects in the primary teeth of Brazilian children
    Sandra Espíndola Lunardelli
    Municipal Health Authority, Itajai, Santa Catarina, Brazil
    J Dent Child (Chic) 73:70-8. 2006
    ..The purpose of this study was to examine the association between developmental defects in the enamel (DDE) of the primary teeth and low birth weight or prematurity...
  30. ncbi Prevalence of developmental defects of enamel in children and adolescents with asthma
    Rodrigho Pelisson Guergolette
    Londrina State University, Londrina, Brazil
    J Bras Pneumol 35:295-300. 2009
    ..This study aimed to evaluate the prevalence of developmental defects of enamel (DDEs) in relation to asthma severity, symptom onset and pharmacological treatment in pediatric asthma patients...
  31. ncbi [Prevalence of enamel defects and the relationship to dental caries in deciduous and permanent dentition in Indaiatuba, São Paulo, Brazil]
    Rosana H Schlittler Hoffmann
    Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, Brasil
    Cad Saude Publica 23:435-44. 2007
    ..The results of this study indicated that children had increased odds of dental caries when enamel defect was present, both in deciduous and permanent dentition; further studies are needed to give evidence to this association...
  32. ncbi The contribution of life course determinants to early childhood caries: a 2-year cohort study
    Y Zhou
    Department of Preventive Dentistry, Guanghua School of Stomatology, Guangzhou, China
    Caries Res 46:87-94. 2012
    ..There are few data available on the risk factors contributing to ECC in children under the age of 3 years. In this study we investigate the risk factors for ECC in the life course of a cohort of 8-month-old children...
  33. ncbi Dental health of aboriginal pre-school children in Brisbane, Australia
    W K Seow
    Department of Dentistry, University of Queensland, Brisbane, Australia
    Community Dent Oral Epidemiol 24:187-90. 1996
    ..It is hypothesized that the high levels of underlying developmental enamel defects, compounded by low fluoride exposure, poor oral hygiene and a diet high in refined sugars pose an important caries risk factor in this group of children...
  34. ncbi Enamel defects and dental caries among Southland children
    Timothy D Mackay
    Southland District Health Board, Invercargill
    N Z Dent J 101:35-43. 2005
    ....
  35. ncbi Prevalence of molar-incisor hypomineralisation observed using transillumination in a group of children from Barcelona (Spain)
    Teresita Patricia Martínez Gómez
    Department of Paediatric Dentistry, Faculty of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain
    Int J Paediatr Dent 22:100-9. 2012
    ..The objectives were to investigate the prevalence of the condition, by using transillumination, in a group of children. Analysed the prevalence with regard to gender, jaw affected, and the teeth that exhibited dysplasia most commonly...
  36. ncbi Risk factors in the occurrence of enamel defects of the first permanent molars among schoolchildren in Western Australia
    Peter Arrow
    Dental Health Services, Health Department of Western Australia and The Dental School, University of Western Australia, Perth, WA, Australia
    Community Dent Oral Epidemiol 37:405-15. 2009
    ..The aim of this study was to examine the possible risk factors for enamel defects in the first permanent molars among children in Western Australia...
  37. ncbi Prevalence of dental enamel defects in celiac patients with deciduous dentition: a pilot study
    E Ortega Páez
    Department of Pediatrics, Virgen de las Nieves University Hospital, University of Granada, Granada, Spain
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:74-8. 2008
    ..To describe the prevalence of unspecific and systematic enamel defects in children with deciduous dentition diagnosed with celiac disease compared with a control group...
  38. ncbi Prevalence of developmental enamel defects of the first permanent molars among school children in Western Australia
    P Arrow
    Department of Health, Western Australia, The University of Western Australia
    Aust Dent J 53:250-9. 2008
    ..The aim of this study was to describe the prevalence of enamel defects in the first permanent molars among school children in Western Australia...
  39. ncbi Developmental enamel defects of the primary dentition in a group of Californian children
    W A Nation
    Department of Pediatric Dentistry, Loma Linda University Dental School
    ASDC J Dent Child 54:330-4. 1987
    ..The most frequently given was hyperbilirubinemia...
  40. ncbi Enamel hypoplasia in the primary dentition: a review
    W K Seow
    University of Queensland Dental School, Brisbane, Australia
    ASDC J Dent Child 58:441-52. 1991
    ..It is likely that many of these individual factors may in fact act through a central mechanism: mineral deficiency...
  41. ncbi Prevalence and distribution of developmental enamel defects in the primary dentition of pre-school children
    Sandra Espíndola Lunardelli
    Department of Public Health, Federal University of Santa Catarina
    Braz Oral Res 19:144-9. 2005
    ..1% (CI 95% 11.7-18.5) was observed, with the most affected teeth being the canines (33.6%) and second molars (33.6%). One quarter of the pre-school children presented enamel defects, with diffuse opacities being the most prevalent ones...
  42. ncbi Photographs as a means of assessing developmental defects of enamel
    Hai Ming Wong
    Paediatric Dentistry and Orthodontics, Faculty of Dentistry, University of Hong Kong, China
    Community Dent Oral Epidemiol 33:438-46. 2005
    ..To evaluate the validity and reliability of photographic examinations for developmental defects of enamel (DDE) in maxillary and mandibular incisors and canines using a standardized process...
  43. ncbi A detailed study of enamel hypoplasia in a post-medieval adolescent of known age and sex
    T King
    Human Origins Group, Department of Palaeontology, The Natural History Museum, Cromwell Road, SW7 5BD, London, UK
    Arch Oral Biol 47:29-39. 2002
    ..5 years and the last growth disruption occurred when she was 4.6 years of age. The distribution of the defects was examined to identify any seasonal pattern in the occurrence of the growth disturbances...
  44. ncbi Does caries in primary teeth predict enamel defects in permanent teeth? A longitudinal study
    J M Broadbent
    Faculty of Dentistry, University of Otago, PO Box 647, Dunedin, New Zealand
    J Dent Res 84:260-4. 2005
    ..3, 95% CI 1.3, 4.1; adjusted OR = 2.2, 95% CI 1.1, 4.3). These findings support a time-ordered association between dental caries in primary maxillary incisors and demarcated opacities in their permanent successors...
  45. ncbi Risk indicators for early childhood caries in 2-year-old children in southern China
    Y Zhou
    Department of Preventive Dentistry, Guanghua School of Stomatology, Sun Yat Sen University, Guangzhou, China
    Aust Dent J 56:33-9. 2011
    ..The aim of this study was to explore the relationship between early childhood caries (ECC) and relevant socio-economic, behavioural and biological experiences in the life course of children...
  46. ncbi Esthetic perception and psychosocial impact of developmental enamel defects among Malaysian adolescents
    Sharol Lail Sujak
    Kuala Lumpur Dental Division, Ministry of Health Malaysia
    J Oral Sci 46:221-6. 2004
    ..Two-thirds of the subjects were affected by enamel defects involving at least one tooth; however, the esthetic perception and psychosocial impact of those affected were minor...
  47. ncbi Otodental syndrome: a case report and genetic considerations
    H O Sedano
    University of Minnesota, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92:312-7. 2001
    ..The parents of the child were not aware of any similarly affected relatives. Suggestions with respect to possible genetic mechanisms and gene participation in the etiology of this syndrome are offered...
  48. ncbi Molar incisor hypomineralization (MIH): clinical presentation, aetiology and management
    K L Weerheijm
    Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry ACTA, Amsterdam, The Netherlands
    Dent Update 31:9-12. 2004
    ..Children at risk should be monitored very carefully during the period of eruption of their first permanent molars. Treatment planning should consider the long-term prognosis of these teeth...
  49. ncbi Otodental syndrome: a case report
    J Diane Colter
    School of Dentistry, University of California Los Angeles, Los Angeles, Calif, USA
    Pediatr Dent 27:482-5. 2005
    ..Radiographs revealed the abnormal molars to possibly be the product of fusion of multiple tooth buds. The pulp chambers appeared to be duplicated, and possibly a supernumerary tooth or complex odontoma is present...
  50. ncbi Prevalence of developmental enamel defects in mentally retarded children
    Alejandra Martinez
    Department of Pathology and Diagnosis, School of Dentistry, University of Concepcion, Chile
    ASDC J Dent Child 69:151-5, 124. 2002
    ..No statistically significant relation was found between presence of DDE and sex, nutritional status of the mother, use of alcohol and tobacco during pregnancy, presence of syndromes, neonatal disturbances and viral diseases...
  51. ncbi ENAM mutations in autosomal-dominant amelogenesis imperfecta
    J W Kim
    Department of Orthodontics and Pediatric Dentistry, University of Michigan Dental Research Lab, 1210 Eisenhower Place, Ann Arbor, MI 48108, USA
    J Dent Res 84:278-82. 2005
    ..In general, mutations in the human enamelin gene cause hypoplastic enamel, often with horizontal grooves, but the severity of the enamel defects is variable, even among individuals with the same mutation...
  52. ncbi Health of infants in an Imperial Roman skeletal sample: perspective from dental microstructure
    Charles Fitzgerald
    Department of Anthropology, McMaster University, Hamilton, Ontario L8S 4L9, Canada
    Am J Phys Anthropol 130:179-89. 2006
    ..These results are discussed in light of historical records of Roman childhood rearing practices...
  53. ncbi Association between developmental defects of enamel and different concentrations of fluoride in the public water supply
    H M Wong
    Paediatric Dentistry and Orthodontics, Faculty of Dentistry, University of Hong Kong, Hong Kong, SAR, China
    Caries Res 40:481-6. 2006
    ..To compare the prevalence and severity of developmental defects of enamel (DDE) among subjects whose maxillary incisors developed during periods with different concentrations of fluoride in the public water supply...
  54. ncbi Transmission electron microscope characterisation of molar-incisor-hypomineralisation
    Zonghan Xie
    School of Engineering, Edith Cowan University, Joondalup, WA, Australia
    J Mater Sci Mater Med 19:3187-92. 2008
    ..An enhanced knowledge of the degradation of structural integrity in hypomineralised enamel could shed light on more appropriate management strategies for these developmental defects...
  55. ncbi Phenotypic diversity and revision of the nomenclature for autosomal recessive amelogenesis imperfecta
    Mohamad Nusier
    Department of Biochemistry and Molecular Biology, Jordan University of Science and Technology, School of Medicine, Irbid, Jordan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:220-30. 2004
    ..The purpose of this study was to characterize the phenotype in 9 families with autosomal recessive amelogenesis imperfecta (ARAI), and to propose a classification system allowing inclusion and delineation of diverse ARAI phenotypes...
  56. ncbi [Diagnosis and treatment of developmental defects of enamel and dentin in young children]
    S Sapir
    Dept of Pediatric Dentistry, The Hebrew University Hadassah School of Dental Medicine, Israel
    Refuat Hapeh Vehashinayim 22:60-74, 91. 2005
    ..This article presents the clinical management of some common dental defects: hypoplasia, diffuse and demarcated opacities, amelogenesis imperfecta and dentinogenesis imperfecta...
  57. ncbi Amelogenin p.M1T and p.W4S mutations underlying hypoplastic X-linked amelogenesis imperfecta
    J W Kim
    Department of Orthodontics and Pediatric Dentistry, University of Michigan Dental Research Lab, 1210 Eisenhower Place, Ann Arbor, MI 48108, USA
    J Dent Res 83:378-83. 2004
    ..Dentin was normal. The severity of the enamel phenotype correlated with the predicted effects of the mutations on amelogenin expression and secretion...
  58. ncbi Prevalence and location of enamel opacities in children after anti-neoplastic therapy
    U Pajari
    Institute of Dentistry, University of Oulu, Finland
    Community Dent Oral Epidemiol 16:222-6. 1988
    ..The results show that childhood cancer and/or the therapy provided for this can affect the developing dentition, involving all teeth in leukemia cases and the permanent teeth of the mixed dentition period in other cancer diseases...
  59. pmc Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpression
    Isabelle Bolon
    Department of Morphology, University of Geneva Medical School, Geneva, Switzerland
    Am J Pathol 164:2299-304. 2004
    ..They also support the hypothesis that plasminogen could play a part in certain skin diseases...
  60. ncbi Long-term effect of different treatment modalities for traumatized primary incisors presenting dark coronal discoloration with no other signs of injury
    Gideon Holan
    Department of Pediatric Dentistry, The Hebrew University Hadassah School of Dental Medicine, founded by the Alpha Omega Fraternity, Jerusalem, Israel
    Dent Traumatol 22:14-7. 2006
    ....
  61. ncbi Amelogenesis imperfecta: enamel ultra structure and molecular studies
    V K Gopinath
    School of Dental Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
    J Clin Pediatr Dent 28:319-22. 2004
    ..Hence, it is probable that the AI of this patient is not X-linked. It is more likely to be an autosomal mutation...
  62. ncbi Molar incisor hypomineralization: review and recommendations for clinical management
    Vanessa William
    Royal Children s Hospital, Melbourne, Australia
    Pediatr Dent 28:224-32. 2006
    ..The purpose of this paper was to describe the diagnosis, prevalence, putative etiological factors, and features of hypomineralized enamel in molar incisor hypomineralization and to present a sequential approach to management...
  63. ncbi Enamel defects in children with coeliac disease
    E Farmakis
    Dept Paediatric Dentistry, University of Leeds, England
    Eur J Paediatr Dent 6:129-32. 2005
    ..This was to investigate the prevalence of enamel developmental defects in a group of children with a history of coeliac disease...
  64. ncbi Epidemiologic study of idiopathic enamel hypomineralization in permanent teeth of Swedish children
    G Koch
    Department of Pedodontics, Institute for Postgraduate Dental Education, , Sweden
    Community Dent Oral Epidemiol 15:279-85. 1987
    ..It was found that 15.4% of the children born in 1970 showed such changes. The corresponding figures for children born in 1966, 1969, 1971, 1972 and 1974 were 6.3, 7.3, 7.1, 5.2 and 4.4, respectively...
  65. ncbi Dental health and treatment in a group of children with congenital heart disease
    Vasiliki Tasioula
    Leeds Dental Institute, Leeds, UK
    Pediatr Dent 30:323-8. 2008
    ..The purposes of this study were to: (1) determine the prevalence of dental caries and developmental enamel defects in children with congenital heart (CHD) disease; and (2) evaluate previous dental treatment...
  66. ncbi Can enamel serve as a useful clinical marker of childhood stress?
    H Stefan Bracha
    National Center for PTSD, Department of Veterans Affairs, Spark M Matsunaga Medical and Regional Office Center, Honolulu, Hawaii, USA
    Hawaii Dent J 33:9-10. 2002
  67. ncbi Molar-incisor hypomineralization (MIH) in a group of school-aged children in Benghazi, Libya
    D Fteita
    Pediatric and Preventive Dentistry, Institute of Dentistry, University of Helsinki, Helsinki, Finland
    Eur Arch Paediatr Dent 7:92-5. 2006
    ..The aim of the present study was to assess developmental enamel defects with an emphasis to MIH in children from four primary schools in Benghazi, Libya...
  68. ncbi Long-term effects of chemotherapy on caries formation, dental development, and salivary factors in childhood cancer survivors
    Aysun Avsar
    Department of Pediatric Dentistry, Faculty of Dentistry, University of Ondokuz Mayis, Samsun, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:781-9. 2007
    ..The aim of this study was to investigate the long-term effects of chemotherapy on oral health and dental development in childhood cancer survivors (CCS)...
  69. ncbi Root development in mice lacking functional tissue non-specific alkaline phosphatase gene: inhibition of acellular cementum formation
    W Beertsen
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Dent Res 78:1221-9. 1999
    ..It is concluded that TNAP represents an essential factor in mantle dentin mineralization and in the formation of acellular cementum...
  70. ncbi Prevalence of cheese molars in eleven-year-old Dutch children
    K L Weerheijm
    Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry ACTA, Amsterdam, The Netherlands
    ASDC J Dent Child 68:259-62, 229. 2001
    ..The cause for the phenomenon called cheese molars appears to be child centered. Further studies on prevalence, causes and prevention are mandatory...
  71. ncbi Dental health status in children with acute lymphoblastic leukemia
    V S Nasim
    Department of Pedodontics and Preventive Children Dentistry, A B Shetty Memorial Institute of Dental Sciences, Nithyananda Nagar P O, Deralakatte, Mangalore 575 018, Kamataka, India
    J Clin Pediatr Dent 31:210-3. 2007
    ..History of halitosis before diagnosis of ALL was a predominant feature in a statistically significant number of children...
  72. ncbi The oral health of children with clefts of the lip, palate, or both
    J R Chapple
    Dental Hospital, Newcastle upon Tyne, NE2 4BW, United Kingdom
    Cleft Palate Craniofac J 38:525-8. 2001
    ..These assessments not only provide a baseline on oral health parameters in young people with clefts but underline the need for a more aggressive approach to prevention of oral disease to optimize clinical outcome...
  73. ncbi Caries experience of leukemic children during intensive course of chemotherapy
    Cigdem Elbek Cubukcu
    Pediatric Dental Care Unit, Uluda University, Medical Faculty, Bursa, Turkey
    J Clin Pediatr Dent 32:155-8. 2008
    ..To determine the incidence of dental caries in 64 leukemic children who received dental treatment before the initiation of chemotherapy and had intensive oral care during the course...
  74. ncbi Pulpal expression of TRPV1 in molar incisor hypomineralisation
    H D Rodd
    Dept Oral Health and Development, School of Clinical Dentistry, University of Sheffield, Sheffield England
    Eur Arch Paediatr Dent 8:184-8. 2007
    ..The rationale for the investigation was to gain further insight into pulpal changes in hypomineralised teeth and the possible biological mechanisms underlying thermal hypersensitivity...
  75. ncbi Molar incisor hypomineralization: a study of aetiological factors in a group of UK children
    Rosemary Whatling
    Department of Paediatric Dentistry, Royal London Hospital, London, UK
    Int J Paediatr Dent 18:155-62. 2008
    ..The objectives were to investigate the aetiology of molar incisor hypomineralization (MIH), and to discuss previously published studies...
  76. ncbi Insights from the inside: histological analysis of abnormal enamel microstructure associated with hypoplastic enamel defects in human teeth
    C Witzel
    Department of Biology, University of Hildesheim, D 31141 Hildesheim, Germany
    Am J Phys Anthropol 136:400-14. 2008
    ....
  77. ncbi Amelogenesis imperfecta: a scanning electron microscopic and histopathologic study
    Figen Seymen
    University of Istanbul, Faculty of Dentistry, Department of Pedodontics, Turkey
    J Clin Pediatr Dent 26:327-35. 2002
    ..Conclusively, in amelogenesis imperfecta, enamel tissue is mostly affected besides minor defects in dentinal and pulpal tissue...
  78. ncbi Oral and clinical characteristics of a group of patients with Turner syndrome
    Maria Elena López
    Cátedra de Química Biológia, Faculdad de Odontología, Universidad Nacional de Tucuman, Argentinia
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:196-204. 2002
    ..Records of odontologic alterations of 23 Argentinian patients with TS were compared with those of 25 girls in a control group, and associations were made with medical indications...
  79. ncbi Presence of developmental defects of enamel in cystic fibrosis patients
    Tatiana Degani Paes Leme Azevedo
    School of Dentistry, Catholic University of Brasilia CUB, Brasilia, Brazil
    J Dent Child (Chic) 73:159-63. 2006
    ....
  80. ncbi Difference in the prevalence of enamel alterations affecting central incisors of children with complete unilateral cleft lip and palate
    Suzana Papile Maciel
    Pediatric Dentistry, Hospital for Rehabilitation of Craniofacial Anomalies HRAC USP, Bauru, Sao Paulo, Brazil
    Cleft Palate Craniofac J 42:392-5. 2005
    ..To evaluate the prevalence of enamel alterations affecting the deciduous and permanent central maxillary incisors of children with complete unilateral cleft lip and palate and to verify their characteristics...
  81. ncbi Enamel hypoplasia in coeliac children: a potential clinical marker of early diagnosis
    M Bossu
    Department of Pediatric Dentistry, University La Sapienza, Rome, Italy
    Eur J Paediatr Dent 8:31-7. 2007
    ..If the presence of specific features of the EH associated with CD were demonstrated, these findings would represent for the dentist early non-invasive clinical markers of diagnosis of CD in case of suspected disease...
  82. ncbi Molar incisor hypomineralization: a questionnaire inventory of its occurrence in member countries of the European Academy of Paediatric Dentistry (EAPD)
    K L Weerheijm
    Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry ACTA, Amsterdam, The Netherlands
    Int J Paediatr Dent 13:411-6. 2003
    ....
  83. ncbi Gross enamel hypoplasia in molars from subadults in a 16th-18th century London graveyard
    A R Ogden
    Biological Anthropology Research Centre, Archaeological Sciences, University of Bradford, West Yorkshire BD7 1DP, UK
    Am J Phys Anthropol 133:957-66. 2007
    b>Dental Enamel Hypoplasia has long been used as a common nonspecific stress indicator in teeth from archaeological samples. Most researchers report relatively minor linear and pitted hypoplastic defects on tooth crown surfaces...
  84. ncbi Molar incisor hypomineralisation: restorative management
    S A Fayle
    Department of Paediatric Dentistry, Leeds Dental Institute, Leeds, England
    Eur J Paediatr Dent 4:121-6. 2003
    ..The various options for restoration are outlined and recommendations made as to the appropriate types of restoration...
  85. ncbi Prevalence of enamel mineralisation disturbances in an area with 1-1.2 ppm F in drinking water. Review and summary of a report published in Sweden in 1981
    G Koch
    The Institute for Postgraduate Dental Education, Jonkoping, Sweden
    Eur J Paediatr Dent 4:127-8. 2003
    ....
  86. ncbi Disturbed enamel formation in wild boars (Sus scrofa L.) from fluoride polluted areas in Central Europe
    H Kierdorf
    Zoological Institute, University of Cologne, 50923 Koln, Germany
    Anat Rec 259:12-24. 2000
    ..The results indicate that the wild boars had been exposed to a particularly severe fluoride impact during autumn and winter of their first year of life...
  87. ncbi Patterns of dental enamel defects at ancient Mendes, Egypt
    N C Lovell
    Department of Anthropology, University of Alberta, Edmonton, Alberta T6G 2H4, Canada
    Am J Phys Anthropol 110:69-80. 1999
    ..and Greco-Roman periods at the ancient Egyptian site of Mendes (Tell er-Rub(c)a) were examined for dental enamel hypoplasia, and the results reported here provide some of the first comparative data on enamel defects in ancient ..
  88. ncbi Amelogenin-deficient mice display an amelogenesis imperfecta phenotype
    C W Gibson
    Department of Anatomy and Histology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:31871-5. 2001
    ..These null mice will be useful for understanding the functions of amelogenin proteins during enamel formation and for developing therapeutic approaches for treating this developmental defect that affects the enamel...
  89. ncbi A clinical and histological study of dental defects in a 10-year-old girl with pseudoxanthoma elasticum and amelogenesis imperfecta
    Jean Jacques Morrier
    Département d odontologie pédiatrique, Faculté d Odontologie, Université Lyon1, Universite de Lyon, Lyon, France
    Int J Paediatr Dent 18:389-95. 2008
    ..The prominent dental feature of a 10-year-old girl was severely hypoplastic enamel in permanent teeth...
  90. ncbi A new frameshift mutation encoding a truncated amelogenin leads to X-linked amelogenesis imperfecta
    S R Greene
    Department of Anatomy and Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Oral Biol 47:211-7. 2002
    ..While greater than 60% of the protein is predicted to be intact, the severity of this phenotype illustrates the importance of the C-terminal region of the amelogenin protein for the formation of enamel with normal thickness...
  91. ncbi Amelogenesis imperfecta phenotype-genotype correlations with two amelogenin gene mutations
    P S Hart
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Oral Biol 47:261-5. 2002
    ..g. the mutation seen in family 1). This difference suggests that the C-terminus of the normal amelogenin protein is important for controlling enamel thickness...
  92. ncbi Autosomal dominant spondylocarpotarsal synostosis syndrome: phenotypic homogeneity and genetic heterogeneity
    B Isidor
    Service de Genetique Medicale, Nantes University Hospital, Nantes, France
    Am J Med Genet A 146:1593-7. 2008
    ..Cleft palate, sensorineural or mixed hearing loss, joint limitation, clinodactyly, and dental enamel hypoplasia are variable manifestations. Twenty-five patients have been reported...
  93. ncbi Amelogenesis imperfecta and nephrocalcinosis: a new case of this rare syndrome
    Isabelle Normand de la Tranchade
    Université d Odontologie de Bordeaux II, Service d Odontologie Pédiatrique, 16 cours de la Marne, 33000 Bordeaux, France
    J Clin Pediatr Dent 27:171-5. 2003
    ..The early diagnosis provided by the oral symptoms leads to a better renal prognosis. As a consequence, pediatric dentists should be aware of this pathology...
  94. ncbi Effect of acid etching time on bond strength of an etch-and-rinse adhesive to primary tooth dentine affected by amelogenesis imperfecta
    Noriko Hiraishi
    Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong
    Int J Paediatr Dent 18:224-30. 2008
    ..Dentine affected by amelogenesis imperfecta (AI) is histologically altered following loss of the hypoplastic enamel and becomes hypermineralized, which would make bonding less predictable...
  95. ncbi Autosomal-dominant hypoplastic form of amelogenesis imperfecta caused by an enamelin gene mutation at the exon-intron boundary
    M Kida
    Research Group of Human Gene Therapy, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo, 060 8638, Hokkaido, Japan
    J Dent Res 81:738-42. 2002
    ..Thus, heterogeneous mutations in the enamelin gene are responsible for an autosomal-dominant hypoplastic form of AI...
  96. ncbi Severely hypoplastic amelogenesis imperfecta with taurodontism
    Alenka Pavlic
    Department of Paediatric and Preventive Dentistry, University of Ljubljana, Ljubljana, Slovenia
    Int J Paediatr Dent 17:259-66. 2007
    ..The prominent dental feature of a boy was severely hypoplastic enamel in both primary and permanent teeth...
  97. ncbi Health and disease in a Roman walled city: an example of Colonia Iulia Iader
    Mario Novak
    Department of Archaeology, Croatian Academy of Sciences and Arts, Ante Kovacica 5, Zagreb, Croatia
    J Anthropol Sci 88:189-206. 2010
    ..skeletal sample from Zadar, Croatia with the focus on subadult stress indicators (cribra orbitalia and dental enamel hypoplasia) and indicators of non-specific infectious diseases (periostitis)...
  98. ncbi Life stress on the Roman limes in continental Croatia
    M Slaus
    Department of Archaeology, Croatian Academy of Sciences and Arts, Zagreb
    Homo 54:240-63. 2004
    ..All skeletons were also analyzed for the presence of dental pathology, dental enamel hypoplasia, cribra orbitalia, trauma, and physical stress...
  99. ncbi Enamelysin (matrix metalloproteinase 20)-deficient mice display an amelogenesis imperfecta phenotype
    John J Caterina
    Matrix Metalloproteinase Unit, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:49598-604. 2002
    ..Our findings demonstrate that enamelysin activity is essential for proper enamel development...
  100. pmc Natal teeth: a review
    Alexander K C Leung
    The University of Calgary, Alberta, Canada
    J Natl Med Assoc 98:226-8. 2006
    ..Tooth extraction is indicated if the tooth is supernumerary or excessively mobile. If the tooth does not interfere with breastfeeding and is otherwise asymptomatic, no treatment is necessary...
  101. ncbi Evidence for genetic anticipation in the oculodentodigital syndrome
    R E Shapiro
    Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Am J Med Genet 71:36-41. 1997
    ..D.) is an autosomal dominant disorder comprising facial anomalies, syndactyly, microcorneae, dental enamel hypoplasia, and leukodystrophy. We describe a four generation family with O.D...

Research Grants14

  1. Analysis of the Role of Ras Signaling in Amelogenesis
    ALICE FITZGERALD GOODWIN; Fiscal Year: 2012
    ..In addition, exploring the effect of Ras on ameloblast cell polarity will further reveal the general role of Ras in epithelial cell polarity. ..
  2. ENAMEL MATRIX SERINE PROTEINASE 1
    James Simmer; Fiscal Year: 2004
    ..Accomplishing these aims will gain important insights into the action of EMSP1 in the organization, processing, turnover, and degradation of enamel matrix proteins during enamel biomineralization. ..
  3. S MUTANS--CHARACTERIZATION OF ITS MUTACIN ANTIBIOTIC
    PAGE CAUFIELD; Fiscal Year: 2001
    ....
  4. THE GENOTYPE AND PHENOTYPE AMELOGENESIS IMPERFECTA
    John Wright; Fiscal Year: 2004
    ..Knowledge of the molecular determinants of morphogenesis and tissue formation will allow novel and more effective treatments and more accurate diagnosis of the diverse hereditary conditions affecting teeth. ..
  5. Phenotype and Gene Expression in Odontogenic Tumors
    JOHN T WRIGHT; Fiscal Year: 2010
    ..Gene data will be placed on our web site in a timely fashion for data sharing. These studies will provide the first detailed mutational and gene profile studies of human odontogenic tumors. ..
  6. Ameloblast Differentiation In Vitro: A Step Closer to Enamel Engineering
    Pamela DenBesten; Fiscal Year: 2008
    ..In this proposal we propose to identify key factors that direct ameloblast lineage cell fate decisions as they form an enamel matrix. [unreadable] [unreadable] [unreadable]..
  7. MODIFYING GENE DETERMINANTS OF TOOTH AND BONE PHENOTYPES
    John Wright; Fiscal Year: 2007
    ..abstract_text> ..
  8. The Impact of Fluoride on the Rho Signaling Pathway and the Actin Cytoskeleton
    CAROLYN GIBSON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Fluoride Varnish to Prevent Caries in Toddlers - An Expanded Immunization Program
    Peter Milgrom; Fiscal Year: 2008
    ..Keywords: fluoride varnish, dental caries, oral health, early prevention, multi-center, toddlers. [unreadable] [unreadable] [unreadable]..
  10. REGULATION OF EXPRESSION OF THE AMELOGENIN GENES
    CAROLYN GIBSON; Fiscal Year: 2001
    ..This is a unique opportunity to study regulation of a sexually dimorphic gene that has a completely tissue specific pattern of expression. ..
  11. Oral Health Outcomes of Early Childhood Malnutrition
    Walter Psoter; Fiscal Year: 2006
    ..Given the universality of PEM pathophysiology, this study's findings will be generalizable to subsets of U.S. children having 9 oral health disparities. [unreadable] [unreadable]..
  12. Biotech & Materials Research to Reduce Caries Disparity
    Peter Milgrom; Fiscal Year: 2005
    ..The conference will be co-sponsored by the Northwest/Alaska Center to Reduce Oral Health Disparities, the University of Washington UWeb Bioengineering Center, and the Salivary Diagnostics Project. ..
  13. Longitudinal Study of Fluoride, Diet, Caries & Fluorosis
    Steven Levy; Fiscal Year: 2008
    ..As studies involving recruitment and successful retention of a cohort from birth are extremely rare, the Iowa Fluoride Study offers a unique opportunity to study these relationships in unprecedented detail. ..
  14. Eda/Edar Regulation of Embryonic SMG Development
    Tina Jaskoll; Fiscal Year: 2007
    ....