esophageal achalasia

Summary

Summary: A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).

Top Publications

  1. ncbi Peroral endoscopic myotomy (POEM) for esophageal achalasia
    H Inoue
    Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224 8503 Japan
    Endoscopy 42:265-71. 2010
  2. ncbi Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism
    Helen L Storr
    Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, United Kingdom
    Mol Endocrinol 23:2086-94. 2009
  3. ncbi The preoperative manometric pattern predicts the outcome of surgical treatment for esophageal achalasia
    Renato Salvador
    Department of Surgical and Gastroenterological Sciences, Clinica Chirurgica I, School of Medicine, University of Padova, Padova, Italy
    J Gastrointest Surg 14:1635-45. 2010
  4. ncbi [Per-oral endoscopic myotomy (POEM) for 43 consecutive cases of esophageal achalasia]
    Haruhiro Inoue
    Digestive Disease Center, Showa University Northern Yokohama Hospital
    Nihon Rinsho 68:1749-52. 2010
  5. ncbi Intracellular ROS level is increased in fibroblasts of triple A syndrome patients
    Barbara Kind
    Children s Hospital, Technical University Dresden, Fetscherstr 74, 01307, Dresden, Germany
    J Mol Med (Berl) 88:1233-42. 2010
  6. pmc Tissue-specific expression and subcellular localization of ALADIN, the absence of which causes human triple A syndrome
    A Ri Cho
    Department of Research Institute of Molecular Genetics, The Catholic University of Korea, Seoul 137 040, Korea
    Exp Mol Med 41:381-6. 2009
  7. ncbi Achalasia of the cardia in Allgrove's (triple A) syndrome: histopathologic study of 10 cases
    Karim Khelif
    Laboratoire de Neurophyisiologie, Faculte de Medecine, Universite Libre de Bruxelles, and Service de Chirurgie Pédiatrique, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium
    Am J Surg Pathol 27:667-72. 2003
  8. ncbi The risk of esophageal resection after esophagomyotomy for achalasia
    Shady M Eldaif
    Division of General Thoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Thorac Surg 87:1558-62; discussion 1562-3. 2009
  9. ncbi Neurological features in adult Triple-A (Allgrove) syndrome
    Anne Evelyne Vallet
    Service d ElectroNeuroMyographie et Pathologie Neuromusculaire, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, HCL, 59 Boulevard Pinel, 69677 Lyon, Bron Cedex, France
    J Neurol 259:39-46. 2012
  10. ncbi Triple A syndrome: 32 years experience of a single centre (1977-2008)
    Tatjana Milenkovic
    Mother and Child Healthcare Institute of Serbia Dr Vukan Cupic, Radoja Dakica 8, Belgrade, Serbia
    Eur J Pediatr 169:1323-8. 2010

Detail Information

Publications267 found, 100 shown here

  1. ncbi Peroral endoscopic myotomy (POEM) for esophageal achalasia
    H Inoue
    Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224 8503 Japan
    Endoscopy 42:265-71. 2010
    Peroral endoscopic myotomy (POEM) was developed by our group to provide a less invasive permanent treatment for esophageal achalasia.
  2. ncbi Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism
    Helen L Storr
    Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, United Kingdom
    Mol Endocrinol 23:2086-94. 2009
    ..Taken together, this work offers a plausible mechanism for the progressive clinical features of triple A syndrome...
  3. ncbi The preoperative manometric pattern predicts the outcome of surgical treatment for esophageal achalasia
    Renato Salvador
    Department of Surgical and Gastroenterological Sciences, Clinica Chirurgica I, School of Medicine, University of Padova, Padova, Italy
    J Gastrointest Surg 14:1635-45. 2010
    A new manometric classification of esophageal achalasia has recently been proposed that also suggests a correlation with the final outcome of treatment...
  4. ncbi [Per-oral endoscopic myotomy (POEM) for 43 consecutive cases of esophageal achalasia]
    Haruhiro Inoue
    Digestive Disease Center, Showa University Northern Yokohama Hospital
    Nihon Rinsho 68:1749-52. 2010
    To establish less invasive permanent treatment for esophageal achalasia, per-oral endoscopic myotomy (POEM) was addressed.
  5. ncbi Intracellular ROS level is increased in fibroblasts of triple A syndrome patients
    Barbara Kind
    Children s Hospital, Technical University Dresden, Fetscherstr 74, 01307, Dresden, Germany
    J Mol Med (Berl) 88:1233-42. 2010
    ..The increased sensitivity to oxidative stress may be a major mechanism for the neurodegeneration in triple A syndrome...
  6. pmc Tissue-specific expression and subcellular localization of ALADIN, the absence of which causes human triple A syndrome
    A Ri Cho
    Department of Research Institute of Molecular Genetics, The Catholic University of Korea, Seoul 137 040, Korea
    Exp Mol Med 41:381-6. 2009
    ..The mutations S544G and S544X show that alteration of S544 residue affects correct targeting of ALADIN to the nuclear membrane...
  7. ncbi Achalasia of the cardia in Allgrove's (triple A) syndrome: histopathologic study of 10 cases
    Karim Khelif
    Laboratoire de Neurophyisiologie, Faculte de Medecine, Universite Libre de Bruxelles, and Service de Chirurgie Pédiatrique, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium
    Am J Surg Pathol 27:667-72. 2003
    ..Other features were less constant and may reflect the variability of disease expression and progression among patients with Allgrove's syndrome...
  8. ncbi The risk of esophageal resection after esophagomyotomy for achalasia
    Shady M Eldaif
    Division of General Thoracic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Thorac Surg 87:1558-62; discussion 1562-3. 2009
    ..However, in patients with a significantly dilated esophagus, many advocate esophageal resection thus forgoing an esophagomyotomy. The purpose of this study is to determine the esophagomyotomy failure rate in patients with achalasia...
  9. ncbi Neurological features in adult Triple-A (Allgrove) syndrome
    Anne Evelyne Vallet
    Service d ElectroNeuroMyographie et Pathologie Neuromusculaire, Hopital Neurologique et Neurochirurgical Pierre Wertheimer, HCL, 59 Boulevard Pinel, 69677 Lyon, Bron Cedex, France
    J Neurol 259:39-46. 2012
    Triple-A or Allgrove syndrome is a rare multisystem disease classically associated with esophageal achalasia, adrenal insufficiency and alacrima...
  10. ncbi Triple A syndrome: 32 years experience of a single centre (1977-2008)
    Tatjana Milenkovic
    Mother and Child Healthcare Institute of Serbia Dr Vukan Cupic, Radoja Dakica 8, Belgrade, Serbia
    Eur J Pediatr 169:1323-8. 2010
    ..In all children with mutation in AAAS gene, regular follow up of adrenal function is necessary to avoid adrenal crisis and start substitution therapy as soon as adrenal insufficiency is noted...
  11. ncbi Restoration of nuclear-import failure caused by triple A syndrome and oxidative stress
    Takao Kiriyama
    Department of Neurology, Faculty of Medicine, Nara Medical University School of Medicine, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Biochem Biophys Res Commun 374:631-4. 2008
    ..These findings may help develop treatments for currently intractable triple A syndrome and other oxidative-stress-related neurological diseases, and contribute to nuclear compartmentalization study...
  12. pmc Classification of oesophageal motility abnormalities
    S J Spechler
    Department of Medicine Dallas VA Medical Center and University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Gut 49:145-51. 2001
    ..This should facilitate and improve comparisons among patients and studies. However, it is important to emphasise that fulfilment of the proposed criteria does not establish the clinical importance of the motility abnormalities...
  13. ncbi Clinical remission in endoscope-guided pneumatic dilation for the treatment of esophageal achalasia: 7-year follow-up results of a prospective investigation
    Seng Kee Chuah
    Division of Hepato Gastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung County, 833, Taiwan, Republic of China
    J Gastrointest Surg 13:862-7. 2009
    ..The aim of this prospective 7-year follow-up study is to report the efficacy of endoscope-guided pneumatic dilation and determine the possible confounding factors related to remission...
  14. pmc Pneumatic dilation for achalasia: late results of a prospective follow up investigation
    V F Eckardt
    Deutsche Klinik fur Diagnostik, Wiesbaden, Germany
    Gut 53:629-33. 2004
    ....
  15. ncbi Triple A syndrome is caused by mutations in AAAS, a new WD-repeat protein gene
    K Handschug
    Children s Hospital, Technical University Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Hum Mol Genet 10:283-90. 2001
    ..The predicted protein belongs to the family of WD repeat-containing proteins which exhibit a high degree of functional diversity including regulation of signal transduction, RNA processing and transcription...
  16. ncbi Long term results of pneumatic dilation in achalasia followed for more than 5 years
    R L West
    Department of Gastroenterology, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Gastroenterol 97:1346-51. 2002
    ..We aimed to evaluate the long term therapeutic outcome in achalasia patients treated with pneumatic dilation, specifically focusing on those patients treated more than 15 yr ago...
  17. ncbi Megaesophagus microbiota: a qualitative and quantitative analysis
    Denis Pajecki
    Department of Gastrointestinal Surgery, University of Sao Paulo School of Medicine, Brazil
    J Gastrointest Surg 6:723-9. 2002
    ..05). It was concluded that patients with megaesophagus have a variety of microbiota consisting mostly of aerobic gram-positive and anaerobic bacteria, in concentrations that varied according to the degree of esophageal dilation...
  18. ncbi Achalasia
    G E E Boeckxstaens
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 21:595-608. 2007
    ..The challenge for the coming years will undoubtedly be to get more insight into the underlying disease mechanisms and to develop a treatment to restore function...
  19. ncbi Cellular localization of 17 natural mutant variants of ALADIN protein in triple A syndrome - shedding light on an unexpected splice mutation
    M Krumbholz
    Children s Hospital, Technical University Dresden, Germany
    Biochem Cell Biol 84:243-9. 2006
    ..Using a patient cell line, we show that the mutation 43C>A in exon 1 does not cause a missense mutation Q15K but, rather, results in aberrant splicing...
  20. ncbi A stepwise approach and early clinical experience in peroral endoscopic myotomy for the treatment of achalasia and esophageal motility disorders
    Lee L Swanstrom
    The Oregon Clinic, Division of GI and Minimally Invasive Surgery, Portland, OR, USA
    J Am Coll Surg 213:751-6. 2011
    ..We describe our approach as well as our initial clinical experience as part of an ongoing study treating achalasia patients with POEM...
  21. pmc Antineuronal antibodies in idiopathic achalasia and gastro-oesophageal reflux disease
    P L Moses
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05401, USA
    Gut 52:629-36. 2003
    ..We screened sera from patients with achalasia or gastro-oesophageal reflux disease (GORD) to test for circulating antimyenteric neuronal antibodies...
  22. ncbi Squamous mucosal alterations in esophagectomy specimens from patients with end-stage achalasia
    M B Lehman
    Center for Swallowing and Esophageal Disorders and the Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Surg Pathol 25:1413-8. 2001
    ..These changes may be related to the increased risk of squamous cell carcinoma in these patients...
  23. ncbi Laparoscopic cardiomyotomy for achalasia: clinical outcomes beyond 5 years
    Zhen Chen
    Department of Surgery, Flinders University, Flinders Medical Centre, Room 3D211, Bedford Park, SA 5042, Australia
    J Gastrointest Surg 14:594-600. 2010
    ..Laparoscopic cardiomyotomy is the most common surgical procedure for the treatment of achalasia, although few reports describe long-term surgical outcomes...
  24. ncbi Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice
    D V Sivarao
    Center for Swallowing and Motility Disorders, Department of Veterans Affairs Medical Center, 1400 VFW Parkway, West Roxbury, Massachusetts 02132, USA
    Gastroenterology 121:34-42. 2001
    ..We determined whether mice with neuronal nitric oxide synthase gene disruption (nNOS(-/-)) and W/W(v) mice lacking ICC-IM have achalasia-like LES dysfunction...
  25. ncbi Review article: an analysis of the efficacy, perforation rates and methods used in pneumatic dilation for achalasia
    D A Katzka
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Aliment Pharmacol Ther 34:832-9. 2011
    ..Pneumatic dilation has re-emerged as a first line treatment for achalasia, but conclusions are limited by the relatively small numbers of patients studied and the lack of long term follow-up...
  26. ncbi New insights into the molecular basis of the triple A syndrome
    A Huebner
    Children s Hospital, Technical University, Fetscherstrasse 74, 01307 Dresden, Germany
    Endocr Res 28:733-9. 2002
    ..The subcellular localization of the protein and the determination of its putative binding partners will shed light on the role of the AAAS protein for the development and function of the adrenal gland and other neuroendocrine structures...
  27. ncbi [Peroral endoscopic myotomy for esophageal achalasia: report of 42 cases]
    Ping Hong Zhou
    Endoscopy Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Wei Chang Wai Ke Za Zhi 14:705-8. 2011
    To evaluate the efficacy and the feasibility of peroral endoscopic myotomy (POEM) for esophageal achalasia (AC).
  28. ncbi Long-term outcome of pneumatic dilation in the treatment of achalasia
    Michael Hulselmans
    Center for Gastroenterological Research, K U Leuven, Leuven, Belgium
    Clin Gastroenterol Hepatol 8:30-5. 2010
    ..Achalasia is treated with pneumatic dilation or Heller myotomy, but studies suggest poor long-term outcomes. We analyzed long-term outcomes after initial pneumatic dilation and studied factors associated with failure...
  29. pmc Triple-A syndrome with prominent ophthalmic features and a novel mutation in the AAAS gene: a case report
    Brian P Brooks
    National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    BMC Ophthalmol 4:7. 2004
    ..Triple-A syndrome (Allgrove syndrome) is an autosomal recessive disorder characterized by adrenal insufficiency, alacrima, achalasia, and - occasionally - autonomic instability. Mutations have been found in the AAAS gene on 12q13...
  30. ncbi Esophageal achalasia in the Veneto region: epidemiology and treatment. Epidemiology and treatment of achalasia
    Nicola Gennaro
    Innovation and Research Unit, Health and Social Agency of Veneto Region, Venice, Italy
    J Gastrointest Surg 15:423-8. 2011
    ..e., endoscopic pneumatic dilation (PD) and surgical myotomy (SM)...
  31. ncbi Functional analysis of long-term outcome after Heller's myotomy for achalasia
    L Yu
    Department of Thoracic Surgery, Beijing Tongren Hospital, Capital Medical University, Bijing, China
    Dis Esophagus 23:277-83. 2010
    ..Surgical intervention does not lead to the return of esophageal peristalsis. Functional damage of LES in patients with achalasia is irreversible...
  32. ncbi Does illness severity matter? A comparison of laparoscopic esophagomyotomy with fundoplication and esophageal dilation for achalasia
    Jason F Reynoso
    Department of Surgery, University of Nebraska, University of Nebraska Medical Center, Omaha, NE, USA
    Surg Endosc 25:1466-71. 2011
    ..The objective of this study was to evaluate and compare outcomes with laparoscopic esophagomyotomy with fundoplication (LM) and esophageal dilation (ED) for hospitalized patients with different illness severity...
  33. pmc Outcomes of treatment of childhood achalasia
    Constance W Lee
    Division of Pediatric Surgery, University of Florida College of Medicine, PO Box 100119, Gainesville, FL 32610, USA
    J Pediatr Surg 45:1173-7. 2010
    ..The optimal management of achalasia in children and adolescents remains unclear. The aim of this study was to review a single institution's experience with endoscopic and surgical interventions in children with achalasia...
  34. ncbi A pneumatic dilation strategy in achalasia: prospective outcome and effects on oesophageal motor function in the long term
    I Bravi
    Cattedra di Gastroenterologia, Dipartimento di Scienze Mediche and Istituto di Biometria e Statistica Medica, Università degli Studi and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Milan, Italy
    Aliment Pharmacol Ther 31:658-65. 2010
    ..Long-term follow-up studies of achalasia after pneumatic dilation, mostly retrospective, have shown variable results...
  35. ncbi Chromosomal fragility in patients with triple A syndrome
    Shalini Reshmi-Skarja
    Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet A 117:30-6. 2003
    ..Our study raises the possibility of an association between chromosomal fragility in band 9q12 and triple A syndrome. Further investigation is necessary to understand the biologic basis of this finding in the context of triple A syndrome...
  36. ncbi A single institution's experience with more than 500 laparoscopic Heller myotomies for achalasia
    Alexander S Rosemurgy
    Department of Surgery, University of South Florida College of Medicine, Tampa General Hospital, Tampa, FL, USA
    J Am Coll Surg 210:637-45, 645-7. 2010
    ..Long-term symptom relief and patient satisfaction after Heller myotomy are being reported. Herein, we report the largest experience of laparoscopic Heller myotomy for the treatment of achalasia...
  37. ncbi Achalasia: botox, dilatation or laparoscopic surgery in 2006
    N Pehlivanov
    Neurogastroenterol Motil 18:799-804. 2006
  38. ncbi Long-term outcome and risk of oesophageal cancer after surgery for achalasia
    G Zaninotto
    Department of General Surgery, S Giovanni e Paolo Hospital, Venice, Padua, Italy
    Br J Surg 95:1488-94. 2008
    ..The aim of the present study was to assess long-term subjective outcomes after cardiomyotomy and partial fundoplication, focusing specifically on the risk of oesophageal cancer...
  39. ncbi Quantitative methods to determine efficacy of treatment in achalasia
    M F Vaezi
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Gastrointest Endosc Clin N Am 11:409-24, viii-ix. 2001
    ..Recent data suggest that barium esophagram may be most practical and informative compared to manometry and scintigraphy in predicting treatment success in achalasia patients after therapy...
  40. pmc Mice lacking the nuclear pore complex protein ALADIN show female infertility but fail to develop a phenotype resembling human triple A syndrome
    Angela Huebner
    Children s Hospital, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Mol Cell Biol 26:1879-87. 2006
    ..Thus, in mice either the function of ALADIN differs from that in humans, its loss can be readily compensated for, or additional factors, such as environmental conditions or genetic modifiers, contribute to the disease...
  41. ncbi The role of barium esophagogram measurements in assessing achalasia patients after endoscope-guided pneumatic dilation
    S K Chuah
    Division of Hepatogastroenterology, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan
    Dis Esophagus 22:163-8. 2009
    ..An additional objective parameter like esophagogram to the subjective symptom scores may be more optimal in assessing clinical remissions...
  42. ncbi Multiple preoperative endoscopic interventions are associated with worse outcomes after laparoscopic Heller myotomy for achalasia
    Christopher W Snyder
    Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA
    J Gastrointest Surg 13:2095-103. 2009
    ..We compared outcomes in patients with and without multiple preoperative endoscopic interventions...
  43. ncbi Esophagectomy for achalasia: patient selection and clinical experience
    E J Devaney
    Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109, USA
    Ann Thorac Surg 72:854-8. 2001
    ....
  44. ncbi Thoracoscopic versus laparoscopic modified Heller Myotomy for achalasia: efficacy and safety in 87 patients
    K C Stewart
    Department of Surgery, Vancouver General Hospital, University of British Columbia, Canada
    J Am Coll Surg 189:164-9; discussion 169-70. 1999
    ..Controversy exists concerning whether the thoracoscopic Heller Myotomy (THM) or laparoscopic Heller myotomy (LHM) technique is the best approach to a modified Heller myotomy for achalasia...
  45. ncbi A single center 26-year experience with treatment of esophageal achalasia: is there an optimal method?
    Aimee C Pastor
    Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Surg 44:1349-54. 2009
    ..Treatment modalities for achalasia are evolving and remain controversial. Herein, we report the relative efficacy and outcomes after dilatation or myotomy in children with achalasia...
  46. ncbi Conservative management of esophageal perforations during pneumatic dilation for idiopathic esophageal achalasia
    Tim Vanuytsel
    Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven, Leuven, Belgium
    Clin Gastroenterol Hepatol 10:142-9. 2012
    ..We investigated risk factors for esophageal perforation after PD and evaluated safety and long-term outcome of nonsurgical management strategies...
  47. pmc Achalasia--a disease of unknown cause that is often diagnosed too late
    Ines Gockel
    Department of General and Abdominal Surgery, University Medical Center of the Johannes Gutenberg University Mainz
    Dtsch Arztebl Int 109:209-14. 2012
    ..Many physicians are inadequately familiar with the clinical features of achalasia. Often, it is not diagnosed until years after the symptoms arise. This is unfortunate, because a delay in diagnosis worsens the prognosis...
  48. ncbi Mutant WD-repeat protein in triple-A syndrome
    A Tullio-Pelet
    Unité de Recherches sur les Handicaps Génétiques de l Enfant INSERM U 393, Paris, France
    Nat Genet 26:332-5. 2000
    ..The expression of the gene in both neuroendocrine and cerebral structures points to a role in the normal development of the peripheral and central nervous systems...
  49. ncbi Pneumatic balloon dilation for esophageal achalasia
    S C Kadakia
    Gastroenterology Service, Department of Medicine, Brooke Army Medical Center, San Antonio, Texas 78234, USA
    Gastrointest Endosc Clin N Am 11:325-46, vii. 2001
    ..The overall complication rate for Rigiflex dilation is about 3% and for Witzel dilation is about 6%. Some patients will develop GER when measured by 24-hour esophageal pH monitoring, but most patients remain asymptomatic...
  50. ncbi A physiologic clinical study of achalasia: should Dor fundoplication be added to Heller myotomy?
    Thomas W Rice
    Center for Swallowing and Esophageal Disorders and the Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 130:1593-600. 2005
    ..Therefore, we objectively studied the physiologic effects of adding Dor fundoplication to Heller myotomy...
  51. ncbi Esophageal achalasia: intrasphincteric injection of botulinum toxin A versus balloon dilation
    S M Muehldorfer
    Department of Medicine I and Medical Informatics, Biometry and Epidemiology, University of Erlangen Nuremberg, Erlangen, Germany
    Endoscopy 31:517-21. 1999
    In patients with esophageal achalasia, pneumatic dilation is the treatment of choice, but it bears the risk of perforation in about 4% of cases...
  52. ncbi Thoracoscopy-assisted Heller myotomy for the treatment of achalasia: results of a minimally invasive technique
    Kenneth A Kesler
    Department of Surgery, Thoracic Division, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Ann Thorac Surg 77:385-91; discussion 391-2. 2004
    ..Since 1998 our institution has utilized a minimally invasive thoracoscopy-assisted technique (ThAM) that allows a myotomy to be performed under direct visualization...
  53. ncbi Expression of p53 as predictor for the development of esophageal cancer in achalasia patients
    I Leeuwenburgh
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre Rotterdam, The Netherlands
    Dis Esophagus 23:506-11. 2010
    ..Further study is needed to determine if patients with p53 overexpression would benefit from intensive surveillance to detect esophageal neoplasia at a potential curable stage...
  54. pmc 2011 update on esophageal achalasia
    Seng Kee Chuah
    Division of Gastroenterology, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 833, Taiwan
    World J Gastroenterol 18:1573-8. 2012
    There have been some breakthroughs in the diagnosis and treatment of esophageal achalasia in the past few years...
  55. ncbi Long-term esophageal cancer risk in patients with primary achalasia: a prospective study
    I Leeuwenburgh
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Am J Gastroenterol 105:2144-9. 2010
    ..Identification of this risk is relevant for patient management. We performed a prospective evaluation of the esophageal cancer risk in a large cohort of achalasia patients with long-term follow-up...
  56. ncbi A short 4-cm oesophageal myotomy relieves the obstructive symptoms of achalasia
    Yahya Almarhabi
    Department of Surgery, Division of Thoracic Surgery, Universite de Montreal, Centre Hospitalier de l Universite de Montreal, Pavillon Lachapelle, Suite D 8051, 1580 rue Sherbrooke Est, Montreal, QC, CH2L 4M1, Canada
    Eur J Cardiothorac Surg 36:894-900. 2009
    ..Controversy still persists regarding the ideal length of myotomy to treat oesophageal achalasia. This investigation reports the effects of a short myotomy with an added partial fundoplication for reflux prevention...
  57. ncbi Long-term effects of myotomy and partial fundoplication for esophageal achalasia
    L Q Chen
    Department of Surgery, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    Dis Esophagus 15:171-9. 2002
    Controversy persists in the surgical approach to treat esophageal achalasia. This investigation reports the long-term effects of esophageal myotomy and partial fundoplication in treating this disorder...
  58. ncbi Treatment of achalasia: botulinum toxin injection vs. pneumatic balloon dilation. A prospective study with long-term follow-Up
    H D Allescher
    Department of Internal Medicine II, Technical University of Munich, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 Munich, Germany
    Endoscopy 33:1007-17. 2001
    ..The aim of the present study was to test the effectiveness, the long-term outcome and the cumulative costs of BTX injection in consecutive patients with symptomatic achalasia in comparison with pneumatic balloon dilation...
  59. ncbi Perioperative management and treatment for complications during and after peroral endoscopic myotomy (POEM) for esophageal achalasia (EA) (data from 119 cases)
    Zhong Ren
    Endoscopy Center, Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
    Surg Endosc 26:3267-72. 2012
    The aim of this study was to investigate the management and treatment for complications during and after peroral endoscopic myotomy (POEM) for patients suffering from esophageal achalasia (EA).
  60. ncbi Risk of esophageal adenocarcinoma in achalasia patients, a retrospective cohort study in Sweden
    Kazem Zendehdel
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Am J Gastroenterol 106:57-61. 2011
    ..Although a greater risk of esophageal squamous cell carcinoma among achalasia patients is fairly well established, no epidemiological study has evaluated the risk of esophageal adenocarcinoma in these patients...
  61. ncbi Electrical stimulation of the vagus nerve restores motility in an animal model of achalasia
    Yashodhan S Khajanchee
    Department of Minimally Invasive Surgery and Surgical Research, Legacy Health System, Portland, Oregon 97227, USA
    J Gastrointest Surg 7:843-9; discussion 849. 2003
    ..Removal of the functional esophageal outlet obstruction, as with a surgical myotomy, may be necessary to obtain significant peristalsis with vagal pacing in severe achalasia...
  62. ncbi Peroral endoscopic myotomy for esophageal achalasia: technique, indication, and outcomes
    Haruhiro Inoue
    Digestive Disease Center, Showa University Northern Yokohama Hospital, Chigasaki Chuo 35 1, Tsuzuki ku, Yokohama 224 8503, Japan
    Thorac Surg Clin 21:519-25. 2011
    ..been developed as an incisionless, minimally invasive endoscopic treatment intending a permanent cure for esophageal achalasia. The concept of endoscopic myotomy was first reported about 3 decades ago, but the direct incision method ..
  63. ncbi Risk and surveillance intervals for squamous cell carcinoma in achalasia
    P M Dunaway
    Department of Gastroenterology, Walter Reed Army Medical Center, Washinghton, DC 20307-5001, USA
    Gastrointest Endosc Clin N Am 11:425-34, ix. 2001
    ..Information is also provided on how different treatment methods impact this disease. Finally, recommendations on surveillance intervals are made, based on an evidence-based approach...
  64. ncbi Laparoscopic Heller myotomy and Dor fundoplication for achalasia: analysis of successes and failures
    M G Patti
    Department of Surgery, University of California, 533 Parnassus Ave, Room U 122, San Francisco, CA 94143 0788, USA
    Arch Surg 136:870-7. 2001
    ..The results of laparoscopic Heller myotomy have proven to be so good, however, that most experts now consider surgery the primary treatment...
  65. ncbi Familial glucocorticoid deficiency with achalasia of the cardia associated with mixed neuropathy, long-tract degeneration and mild dementia
    D B Grant
    Hospital for Sick Children, London, United Kingdom
    Eur J Pediatr 151:85-9. 1992
    ..The cause of the neurological disorder, low red-cell folate concentrations, and amine disturbance remains unknown, as does the pathogenesis of the adrenocortical failure...
  66. ncbi Oesophagitis is common in patients with achalasia after pneumatic dilatation
    I Leeuwenburgh
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 23:1197-203. 2006
    ..Treatment aims at lowering of the lower oesophageal sphincter pressure, enhancing the risk of gastro-oesophageal reflux. Nevertheless, the incidence of oesophagitis after achalasia treatment is unknown...
  67. ncbi Attenuated nitrergic inhibitory neurotransmission to interstitial cells of Cajal in the lower esophageal sphincter with esophageal achalasia in children
    Yoshio Watanabe
    Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Pediatr Int 44:145-8. 2002
    b>Esophageal achalasia (EA) is a rare disease in children, the etiology and pathogenesis of which remain controversial...
  68. ncbi Esophageal achalasia and alacrima in siblings
    Amar Singh
    Amardeep Multispeciality Childrens Hospital and Research Center, Gujarat College Cricket Ground Road, Ellisbridge, Ahmedabad 380006, Gujarat, India
    Indian Pediatr 43:161-3. 2006
    ..We present two siblings with familial achalasia and alacrima treated at 3 months and 9 years respectively...
  69. ncbi Laparoscopic esophagomyotomy for achalasia without a complementary antireflux procedure
    Theodoros Diamantis
    First Department of Surgery, Laikon Hospital, Athens, Greece
    J Laparoendosc Adv Surg Tech A 16:345-9. 2006
    ..We analyzed the 5-year experience at our institution with laparoscopic Heller myotomy without an antireflux procedure to determine its results, particularly regarding postoperative gastroesophageal reflux...
  70. ncbi Pneumatic dilatation and surgical myotomy for achalasia
    Steven R Lopushinsky
    Department of Surgery, University of Toronto, Toronto, Ontario
    JAMA 296:2227-33. 2006
    ..Pneumatic dilatation and surgical (Heller) myotomy are the 2 principal methods for treatment of achalasia. There are no population-based studies comparing outcomes of these 2 treatments in typical practice settings...
  71. ncbi Pneumatic balloon dilatation in achalasia: a prospective comparison of safety and efficacy with different balloon diameters
    J Mikaeli
    Digestive Disease Research Centre DDRC, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Aliment Pharmacol Ther 20:431-6. 2004
    ..There is also no consensus on the optimal method for performing pneumatic dilation as regard to balloon diameter, amount and the rate inflation pressure...
  72. ncbi Repeated pneumatic dilations as long-term maintenance therapy for esophageal achalasia
    Frank Zerbib
    Department of Gastroenterology, Hôpital Saint André, Bordeaux, France
    Am J Gastroenterol 101:692-7. 2006
    In esophageal achalasia, pneumatic dilations (PD) provide short-term and long-term remission rates of 60-90% and 40-50%, respectively...
  73. ncbi [Surgically treated megaesophagus: epidemiological profile of patients operated in the Clinical Hospital of the State University of Campinas between 1989 and 2005]
    Gustavo Carvalho de Oliveira
    Departamento de Cirurgia, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, SP
    Rev Soc Bras Med Trop 41:183-8. 2008
    ..8% of the patients underwent cardiomyotomy; and e) there were frequent associations with gastritis, esophagitis, megacolon, arterial hypertension and cardiopathy...
  74. ncbi [Digital videofluorography and esophageal achalasia: from diagnosis to follow-up]
    Eugenio Fiorentino
    Dipartimento di Scienze Radiologiche, Universita degli Studi di Palermo
    Chir Ital 57:59-64. 2005
    ..was to evaluate the use of digital videofluorography in the preoperative and postoperative management of esophageal achalasia surgical treatment...
  75. ncbi Laparoscopic Heller myotomy for achalasia
    Robert N Cacchione
    Department of Surgery, University of Louisville School of Medicine, 2nd Floor ACB, Louisville, KY 40202, USA
    Am J Surg 190:191-5. 2005
    ..There is evidence to suggest viral, autoimmune, and hereditary etiologies. There are many treatment options available including medications, botulinum toxin injection, pneumatic dilation, and surgical myotomy...
  76. pmc The "learning curve" in videoscopic Heller myotomy
    Mark Bloomston
    Department of Surgery, University of South Florida College of Medicine, Tampa, USA
    JSLS 6:41-7. 2002
    ..We sought to determine whether the outcome following videoscopic Heller myotomy is influenced by surgeon experience...
  77. pmc Achalasia: a new clinically relevant classification by high-resolution manometry
    John E Pandolfino
    Northwestern University, The Feinberg School of Medicine, Department of Medicine, Chicago, Illinois, USA
    Gastroenterology 135:1526-33. 2008
    ..This study aimed to compare the clinical characteristics and treatment response of these 3 subtypes...
  78. pmc Timed barium oesophagram: better predictor of long term success after pneumatic dilation in achalasia than symptom assessment
    M F Vaezi
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Gut 50:765-70. 2002
    ..Recently, we showed that symptom relief and objective oesophageal emptying are concordant in about 70% of patients, while up to 30% of achalasia patients report near complete symptom relief despite poor oesophageal emptying of barium...
  79. ncbi Pseudoachalasia: a case series and analysis of the literature
    Ines Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University Mainz, Germany
    Scand J Gastroenterol 40:378-85. 2005
    ..Mechanisms proposed to explain the clinical features of pseudoachalasia include a circumferential mechanical obstruction of the distal esophagus or a malignant infiltration of inhibitory neurons within the myenteric plexus...
  80. ncbi Long-term functional results after laparoscopic surgery for esophageal achalasia
    John Tsiaoussis
    Gastrointestinal Motility Unit, Department of General Surgery, University Hospital of Heraklion, Heraklion, Crete, GR 711 10 Greece
    Am J Surg 193:26-31. 2007
    ..The aim of this study was to assess the long-term outcome of achalasic patients after surgery, particularly in relation to the radiologic preoperative stage of the disease...
  81. ncbi Laparoscopic management of idiopathic esophageal achalasia
    Ketan M Desai
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Rev Gastroenterol Mex 69:7-13. 2004
    Idiopathic esophageal achalasia was described in 1682 as a motor disorder of smooth muscle...
  82. ncbi Achalasia: physiology and etiopathogenesis
    R E Kraichely
    Enteric Neuroscience Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Dis Esophagus 19:213-23. 2006
    ....
  83. ncbi Treatment of achalasia: lessons learned with Chagas' disease
    F A M Herbella
    Department of Surgery, Division of Esophagus and Stomach, Federal University of Sao Paulo, Sao Paulo, Brazil
    Dis Esophagus 21:461-7. 2008
    ..Minimally invasive approach to esophageal resection may change this concept, although few centers perform the procedure routinely...
  84. ncbi Etiology and pathogenesis of achalasia: the current understanding
    Woosuk Park
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 100:1404-14. 2005
    ..Further studies are needed to better understand the etiology and pathogenesis of achalasia-such an understanding will be important in developing safe, effective, and possibly curative therapy for achalasia...
  85. ncbi Early results of laparoscopic Heller myotomy do not necessarily predict long-term outcome
    Mark Bloomston
    Department of Surgery, University of South Florida, P O Box 1289, Room F 145, Tampa, FL 33601, USA
    Am J Surg 187:403-7. 2004
    ..We sought to evaluate how patients' symptoms evolve after laparoscopic Heller myotomy...
  86. ncbi Functional results after laparoscopic Heller myotomy for achalasia: A comparative study to open surgery
    Richard Douard
    Department of Surgery, Cochin University Hospital, Paris, France
    Surgery 136:16-24. 2004
    Prospective studies comparing laparoscopic to open Heller myotomy for esophageal achalasia are lacking. The aim of this study was to compare functional outcome after laparoscopic and open Heller myotomy for esophageal achalasia.
  87. pmc A total fundoplication is not an obstacle to esophageal emptying after heller myotomy for achalasia: results of a long-term follow up
    Gianluca Rossetti
    I Division of General and Gastrointestinal Surgery, Second University of Naples, Naples, Italy
    Ann Surg 241:614-21. 2005
    The aim of this study was to evaluate the role and efficacy of a total 360 degrees wrap, Nissen-Rossetti fundoplication, after esophagogastromyotomy in the treatment of esophageal achalasia.
  88. ncbi Relief of dysphagia after laparoscopic Heller myotomy improves long-term quality of life
    Yassar Youssef
    Department of Surgery, Vanderbilt University School of Medicine, D 5203 MCN, Nashville, Tennessee 37232, USA
    J Gastrointest Surg 11:309-13. 2007
    ..The aim of the study was to assess the impact of residual dysphagia on QoL after laparoscopic Heller myotomy for achalasia...
  89. pmc Etiology, diagnosis, and treatment of failures after laparoscopic Heller myotomy for achalasia
    Giovanni Zaninotto
    Department of Medical and Surgical Sciences, Clinica Chirurgica IV, University of Padova School of Medicine, Padova, Italy
    Ann Surg 235:186-92. 2002
    ..To assess the causes of failure of laparoscopic Heller myotomy and to verify whether endoscopic pneumatic dilation is a feasible treatment...
  90. ncbi Minimally invasive surgery for esophageal achalasia
    G Zaninotto
    Department of Medical and Surgical Sciences, Clinica Chirurgica IV, University of Padua, School of Medicine, Italy
    J Laparoendosc Adv Surg Tech A 11:351-9. 2001
    b>Esophageal achalasia is characterized by loss of peristaltic activity and failure of relaxation of the lower esophageal sphincter (LES). The characteristic dysphagia may be alleviated by surgery, dilations, or botulinum toxin injections...
  91. ncbi Current trends in the management of achalasia
    S Bruley des Varannes
    Department of Gastroenterology and Hepatology, Faculty of Medicine, University of Nantes, France
    Dig Liver Dis 33:266-77. 2001
    ..Future approaches to achalasia may markedly change from the suggested algorithm depending on the long-term efficacy and safety as well as cost analysis of BoTox injection and of minimally invasive surgery...
  92. ncbi Robot-assisted laparoscopic Heller cardiomyotomy: preliminary UK results
    S Undre
    Department of Surgical Oncology and Technology, Imperial College, St Mary s Hospital, London, UK
    Dig Surg 21:396-400. 2004
    ..We present our initial experience in robot-assisted laparoscopic Heller cardiomyotomy without addition of an antireflux procedure and discuss the relative merits and disadvantages of the procedure...
  93. ncbi Laparoscopic Heller myotomy with or without partial fundoplication: a matter of debate
    G Ramacciato
    Facolta di Medicina e Chirurgia, Universita degli Studi di Roma La Sapienza, Ospedale Sant Andrea, UOC Chirurgia D, Via di Grottarossa no 1035 1037, 00189 Rome, Italy
    World J Gastroenterol 11:1558-61. 2005
    To present our experience of laparoscopic Heller stretching myotomy followed by His angle reconstruction as surgical approach to esophageal achalasia.
  94. ncbi Laparoscopic cardiomyotomy for achalasia: long-term outcomes
    Justin R Bessell
    Flinders University Department of Surgery, Flinders Medical Centre, Bedford Park, SA, Australia
    ANZ J Surg 76:558-62. 2006
    ..In addition, we sought to identify preoperative factors predicting a good postoperative outcome...
  95. ncbi Self-expanding metal stents for endoscopic treatment of esophageal achalasia unresponsive to conventional treatments. Long-term results in eight patients
    G D De Palma
    Digestive Endoscopy Service, Dept of Surgery and Advanced Technologies, School of Medicine, University Federico II, Via De Gasperi, n 7, 80033 Cicciano, Naples, Italy
    Endoscopy 33:1027-30. 2001
    The successful use of self-expanding metal stents has been demonstrated in the management of malignant esophagocardial strictures. This report assesses the role stents may play in the treatment of esophageal achalasia in selected patients.
  96. pmc Recurrent achalasia treated with Heller myotomy: a review of the literature
    Lan Wang
    The First Affiliated Hospital, Medical College, Zhejiang University, Zhejiang Province, China
    World J Gastroenterol 14:7122-6. 2008
    ..To evaluate the efficacy and safety of Heller myotomy (HM) for recurrent achlasia, performed after different methods of first-line treatment...
  97. ncbi Treatment of esophageal achalasia with laparoscopic Heller myotomy and Dor partial anterior fundoplication: prospective evaluation of 100 consecutive patients
    G Zaninotto
    Department of Medical and Surgical Sciences Clinica Chirurgica IV, University of Padua School of Medicine, Italy
    J Gastrointest Surg 4:282-9. 2000
    ..It was concluded that laparoscopic Heller myotomy with Dor fundoplication is a feasible and effective treatment for achalasia, with an actuarial success rate of 90% at 5 years...
  98. ncbi Randomized controlled trial of laparoscopic Heller myotomy plus Dor fundoplication versus Nissen fundoplication for achalasia: long-term results
    Fabrizio Rebecchi
    General Surgery and Center for Minimal Invasive Surgery, University of Turin, Turin, Italy
    Ann Surg 248:1023-30. 2008
    ..To compare in a prospective, randomized trial the long-term results of laparoscopic Heller myotomy plus Dor fundoplication versus laparoscopic Heller myotomy plus floppy-Nissen for achalasia...
  99. pmc Gender effect on clinical features of achalasia: a prospective study
    Javad Mikaeli
    Achalasia Research Unit, Digestive Disease Research Center, Tehran University of Medical Sciences, Shariati Hospital, Tehran 14114, Iran
    BMC Gastroenterol 6:12. 2006
    ..Achalasia is a well-characterized esophageal motor disorder but the rarity of the disease limits performing large studies on its demographic and clinical features...
  100. ncbi Robotic-assisted Heller myotomy versus laparoscopic Heller myotomy for the treatment of esophageal achalasia: multicenter study
    Santiago Horgan
    Minimally Invasive Surgery, University of Illinois, Chicago, Illinois 60612, USA
    J Gastrointest Surg 9:1020-9; discussion 1029-30. 2005
    ..At short-term follow-up, relief of dysphagia was equally achieved in both groups..
  101. ncbi Laparoscopic Heller myotomy with Toupet fundoplication: outcomes predictors in 121 consecutive patients
    Yashodhan S Khajanchee
    Minimally Invasive Surgery Department, Legacy Health System, Portland, Ore, USA
    Arch Surg 140:827-33; discussion 833-4. 2005
    ....

Research Grants11

  1. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  2. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..These methods will be employed pre- and post-therapy on all patients to assess their potential clinical utility, especially in those unresponsive to medical therapy after aggressive acid suppression. ..
  3. Use of Quantitative RT-PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2009
    ..In addition, we believe that this research will answer some very interesting questions about tumor biology and metastasis in esophageal cancer. ..
  4. Micro RNA expression in esophageal adenocarcinoma
    Virginia Litle; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. Research Symposium on Functional Abdoninal Pain in Children
    Samuel Nurko; Fiscal Year: 2007
    ..7. To educate the NASPGHAN membership on the state of the art of functional abdominal pain and IBS in children. [unreadable] [unreadable] [unreadable]..
  6. PLACEBO CONTROLLED STUDY OF BACLOFEN FOR GERD IN CHILDREN WITH CEREBRAL PALSY
    Samuel Nurko; Fiscal Year: 2008
    ..This study will serve as a basis to test the medication in otherwise healthy children with GERD. [unreadable] [unreadable] [unreadable]..
  7. MOLECULAR BIOLOGY OF THE HEPATITIS B TYPE VIRUSES
    Don Ganem; Fiscal Year: 2002
    ..In addition, detailed studies of the mechanisms of HDV RNA replication will be conducted, with emphasis on the involvement of host factors in this important reaction. ..
  8. The acd mouse: a model for congenital adrenal hypoplasia
    Catherine Keegan; Fiscal Year: 2006
    ..Ultimately, through this additional training I will be poised to continue my long-term career goal of becoming an Independent Investigator. ..
  9. Pathophysiology of lytic reactivation and spread of KSHV
    Don Ganem; Fiscal Year: 2006
    ....
  10. Herpresviral Gene Expression in Kaposis Sarcoma
    Don Ganem; Fiscal Year: 2010
    ..By determining how viral infection leads to KS, we hope to identify molecular targets that can explain how the disease arises;these could also serve as targets for the therapies of the future. ..