esophageal motility disorders

Summary

Summary: Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).

Top Publications

  1. pmc Evaluation of esophageal function in patients with esophageal motor abnormalities using multichannel intraluminal impedance esophageal manometry
    Yu Kyung Cho
    Department of Internal Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, Banpodong 505, Seochogu, Seoul, Korea
    World J Gastroenterol 12:6349-54. 2006
  2. ncbi Selective use of esophageal manometry and 24-Hour pH monitoring before laparoscopic fundoplication
    Constantine T Frantzides
    Department of Surgery, Rush University, Chicago, IL 60612, USA
    J Am Coll Surg 197:358-63; discussion 363-4. 2003
  3. ncbi Spectrum of esophageal motility disorders: implications for diagnosis and treatment
    Marco G Patti
    Department of Surgery, University of California, San Francisco 94143 0788, USA
    Arch Surg 140:442-8; discussion 448-9. 2005
  4. pmc Ineffective oesophageal motility: manometric subsets exhibit different symptom profiles
    Horst Gunter Haack
    Department of Gastroenterology, Gastrointestinal Investigation Unit, Royal North Shore Hospital, University of Sydney, Australia
    World J Gastroenterol 14:3719-24. 2008
  5. pmc Chicago classification criteria of esophageal motility disorders defined in high resolution esophageal pressure topography
    A J Bredenoord
    Department of Gastroenterology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Neurogastroenterol Motil 24:57-65. 2012
  6. pmc Classification of oesophageal motility abnormalities
    S J Spechler
    Department of Medicine Dallas VA Medical Center and University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Gut 49:145-51. 2001
  7. pmc Abnormal oesophageal motility in patients with chronic cough
    J A Kastelik
    Division of Academic Medicine, Postgraduate Medical Institute, University of Hull, Hull, UK
    Thorax 58:699-702. 2003
  8. pmc Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis
    Florian Rieder
    Dept of Gastroenterology and Hepatology, NC22, Cleveland Clinic Foundation 9500 Euclid Ave, Cleveland, OH, 44195
    Am J Physiol Gastrointest Liver Physiol 298:G571-81. 2010
  9. pmc Relevance of ineffective oesophageal motility during oesophageal acid clearance
    M Simren
    Centre for Gastroenterological Research, Catholic University of Leuven, Belgium
    Gut 52:784-90. 2003
  10. ncbi Gastro-esophageal reflux and esophageal motility disorders in morbidly obese patients
    M Suter
    Department of Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Obes Surg 14:959-66. 2004

Detail Information

Publications202 found, 100 shown here

  1. pmc Evaluation of esophageal function in patients with esophageal motor abnormalities using multichannel intraluminal impedance esophageal manometry
    Yu Kyung Cho
    Department of Internal Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, Banpodong 505, Seochogu, Seoul, Korea
    World J Gastroenterol 12:6349-54. 2006
    ....
  2. ncbi Selective use of esophageal manometry and 24-Hour pH monitoring before laparoscopic fundoplication
    Constantine T Frantzides
    Department of Surgery, Rush University, Chicago, IL 60612, USA
    J Am Coll Surg 197:358-63; discussion 363-4. 2003
    ..Here we review our experience with the selective preoperative workup of patients undergoing fundoplication to treat gastroesophageal reflux disease...
  3. ncbi Spectrum of esophageal motility disorders: implications for diagnosis and treatment
    Marco G Patti
    Department of Surgery, University of California, San Francisco 94143 0788, USA
    Arch Surg 140:442-8; discussion 448-9. 2005
    The named primary esophageal motility disorders (PEMDs) are achalasia, diffuse esophageal spasm (DES), nutcracker esophagus (NE), and hypertensive lower esophageal sphincter (HTN-LES)...
  4. pmc Ineffective oesophageal motility: manometric subsets exhibit different symptom profiles
    Horst Gunter Haack
    Department of Gastroenterology, Gastrointestinal Investigation Unit, Royal North Shore Hospital, University of Sydney, Australia
    World J Gastroenterol 14:3719-24. 2008
    ....
  5. pmc Chicago classification criteria of esophageal motility disorders defined in high resolution esophageal pressure topography
    A J Bredenoord
    Department of Gastroenterology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Neurogastroenterol Motil 24:57-65. 2012
    ....
  6. pmc Classification of oesophageal motility abnormalities
    S J Spechler
    Department of Medicine Dallas VA Medical Center and University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Gut 49:145-51. 2001
    ..This should facilitate and improve comparisons among patients and studies. However, it is important to emphasise that fulfilment of the proposed criteria does not establish the clinical importance of the motility abnormalities...
  7. pmc Abnormal oesophageal motility in patients with chronic cough
    J A Kastelik
    Division of Academic Medicine, Postgraduate Medical Institute, University of Hull, Hull, UK
    Thorax 58:699-702. 2003
    ..The aim of this study was to determine the prevalence of abnormal oesophageal motility in a selected group of patients with chronic cough...
  8. pmc Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis
    Florian Rieder
    Dept of Gastroenterology and Hepatology, NC22, Cleveland Clinic Foundation 9500 Euclid Ave, Cleveland, OH, 44195
    Am J Physiol Gastrointest Liver Physiol 298:G571-81. 2010
    ..Novel findings regarding the pathophysiology of esophageal inflammation should enhance our understanding of GERD and its complications and provide new treatment insights...
  9. pmc Relevance of ineffective oesophageal motility during oesophageal acid clearance
    M Simren
    Centre for Gastroenterological Research, Catholic University of Leuven, Belgium
    Gut 52:784-90. 2003
    ..Intraluminal impedance allows non-radiological monitoring of movement of oesophageal liquids...
  10. ncbi Gastro-esophageal reflux and esophageal motility disorders in morbidly obese patients
    M Suter
    Department of Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Obes Surg 14:959-66. 2004
    ..studied a large number of morbidly obese candidates for bariatric surgery with objective means, in order to better define the incidence of gastro-esophageal reflux disease (GERD) and esophageal motility disorders in this population.
  11. ncbi Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis
    B Ohlsson
    Department of Clinical Sciences, Gastroenterology Division, Malmo University Hospital, Lund University, Malmo, Sweden
    Diabetologia 49:2010-4. 2006
    ..This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis...
  12. pmc Esophageal motility disorders in terms of pressure topography: the Chicago Classification
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 2951, USA
    J Clin Gastroenterol 42:627-35. 2008
    ..experience will be the judge, but it is our expectation that pressure topography analysis of HRM data, along with its well-defined functional implications, will prove valuable in the clinical management of esophageal motility disorders.
  13. ncbi Effects of bronchial obstruction on lower esophageal sphincter motility and gastroesophageal reflux in patients with asthma
    Frank Zerbib
    Service d Hepato Gastroenterologie, Hôpital Saint André, Bordeaux
    Am J Respir Crit Care Med 166:1206-11. 2002
    ..These results support the belief that, in asthma, bronchial obstruction may be responsible for reflux or may aggravate reflux through a mechanism that remains to be further clarified...
  14. ncbi Deterioration of muscle function in the human esophagus with age
    Hans Gregersen
    Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital, Aalborg, Denmark
    Dig Dis Sci 53:3065-70. 2008
    ..Such changes may contribute to the high prevalence of reflux disease in elderly...
  15. ncbi Esophageal motility disorders in the morbidly obese population
    J S Koppman
    The Bariatric Institute and Section of Minimally Invasive Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA
    Surg Endosc 21:761-4. 2007
    ..This study aimed to determine the prevalence of esophageal motility disorders in obese patients selected for bariatric surgery.
  16. ncbi Myenteric plexus in spastic motility disorders
    J K Champion
    Department of Surgery, Mercer University School of Medicine, Atlanta, GA, U S A
    J Gastrointest Surg 5:514-6. 2001
    ..There was no significant correlation in our series between the presence of ganglia and an elevated lower esophageal sphincter pressure in spastic motility disorders...
  17. ncbi [Aging and esophageal motility in patients with gastroesophageal reflux disease]
    Roberto Oliveira Dantas
    Departamento de Clinica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP
    Arq Gastroenterol 43:107-11. 2006
    ..The impairment of the contractions may be localized only in the distal esophagus or in the entire esophageal body, and may be worse with the aging process...
  18. ncbi Oesophageal dysmotility, delayed gastric emptying and gastrointestinal symptoms in patients with diabetes mellitus
    J Faraj
    Gastroenterology Division, Department of Clinical Sciences, Malmo University Hospital, Lund University, Lund, Sweden
    Diabet Med 24:1235-9. 2007
    ..The aim of this study was to examine whether diabetic patients with gastrointestinal symptoms also have motility disturbances in the oesophagus and stomach and, if so, whether there are any associations between these disturbances...
  19. ncbi Surgical management of esophageal motility disorders
    Todd A Woltman
    Department of Surgery, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195 6410, USA
    J Surg Res 117:34-43. 2004
  20. ncbi Small intestinal manometry in patients with systemic sclerosis
    Kristina Sjolund
    Department of Internal Medicine, Lund University Hospital, Sweden
    Eur J Gastroenterol Hepatol 17:1205-12. 2005
    ....
  21. ncbi Esophageal motility disorders in critically ill patients: a 24-hour manometric study
    C B Kölbel
    IV Medical Clinic, University Hospital of Heidelberg at Mannheim, Germany
    Intensive Care Med 26:1421-7. 2000
    ....
  22. ncbi Treatment of spastic esophageal motility disorders
    Sami R Achem
    Department of Gastroenterology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Gastroenterol Clin North Am 33:107-24. 2004
    ..Recent trials with Botox, nitric oxide derivatives, and SSRIs offer promising results. Rigorous study design that includes large placebo-controlled trials is needed in this area...
  23. ncbi Minimally invasive surgery for esophageal motility disorders
    Nagammapudur S Balaji
    Department of Surgery, University of Southern California, 1510 San Pablo Street, HCC 514, Los Angeles, CA 90033, USA
    Surg Clin North Am 82:763-82. 2002
    ..Endoscopic stapled diverticulotomy is a safe and effective procedure for Zenker's diverticulum and has potential advantages over the open approach...
  24. ncbi Ineffective motility is not a marker for gastroesophageal reflux disease
    Elango Vinjirayer
    Division of Gastroenterology, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 98:771-6. 2003
    ..We evaluated the relationship between esophageal acid exposure and esophageal body motility in patients undergoing both esophageal manometry and 24-h pH metry in the absence of antisecretory therapy...
  25. ncbi [Esophageal transit and esophageal motility disorders in patients with nontoxic goiter and recurrent dysphagia]
    Salvatore Pustorino
    Dipartimento Clinico Sperimentale di Medicina e Farmacologia, Universita, Policlinico G Martino, Messina
    Recenti Prog Med 93:235-9. 2002
    ..It is concluded that esophageal transit delay, early in the upper and prolonged in the lower part of the esophagus, represents the main findings of the esophageal dysfunction in the patients with nontoxic goiter and dysphagia...
  26. ncbi Recent developments in esophageal motor disorders
    Nam Q Nguyen
    Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, South Australia
    Curr Opin Gastroenterol 21:478-84. 2005
    ..This review outlines the major developments in these areas...
  27. ncbi Use of radioisotopic esophageal transit in the assessment of patients with symptoms of reflux and non-specific esophageal motor disorders
    C Iascone
    Dipartimento di Chirurgia, Pietro Valdoni Università degli Studi di Roma La Sapienza, Rome, Italy
    Dis Esophagus 17:218-22. 2004
    ..Radioisotopic esophageal clearance abnormalities are frequently observed in patients with reflux symptoms and are more likely to be associated to hypomotility disorders, i.e. nonpropagated motor activity or low-amplitude contractions...
  28. ncbi Esophageal motility disorders: medical therapy
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Clin Gastroenterol 42:652-8. 2008
    ..This review will briefly discuss the impact, etiology, and diagnosis of esophageal motility disorders, and then focus on the medical management of these disorders using evidence from well-designed, ..
  29. pmc High-resolution manometry: an atlas of esophageal motility disorders and findings of GERD using esophageal pressure topography
    John E Pandolfino
    Department of Medicine, Feinberg School of Medicine, Northwestern University, 676 St Clair Street, Suite 1400, Chicago, IL 60611 2951, USA
    Thorac Surg Clin 21:465-75. 2011
    ..This article provides an HRM-related atlas of esophageal motility disorders focused on dysphagia and gastroesophageal reflux disease (GERD)...
  30. pmc Is ineffective esophageal motility associated with gastropharyngeal reflux disease?
    Kyung Yup Kim
    Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan 602 739, South Korea
    World J Gastroenterol 14:6030-5. 2008
    ..To evaluate the association between ineffective esophageal motility (IEM) and gastropharyngeal reflux disease (GPRD) in patients who underwent ambulatory 24-h dual-probe pH monitoring for the evaluation of supraesophageal symptoms...
  31. ncbi Oesophageal motility disorders
    J E Richter
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lancet 358:823-8. 2001
    ..Secondary oesophageal motility disorders can be caused by collagen vascular diseases, diabetes, Chagas' disease, amyloidosis, alcoholism, myxo-oedema, multiple sclerosis, idiopathic pseudo-obstruction, or the ageing process...
  32. ncbi An analysis of distal esophageal impedance in individuals with and without esophageal motility abnormalities
    Wojciech Blonski
    Division of Gastroenterology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Gastroenterol 42:776-81. 2008
    ..The aim of this study was to analyze and to compare distal esophageal impedance values between healthy volunteers and patients with normal and abnormal esophageal manometry...
  33. ncbi Ineffective oesophageal motility does not affect the clinical outcome of open Nissen fundoplication
    V Munitiz
    Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain
    Br J Surg 91:1010-4. 2004
    ..Nissen fundoplication is considered the 'gold standard' in antireflux surgery but some surgeons employ a different surgical strategy when gastro-oesophageal reflux disease (GORD) is associated with motor disorders of the oesophageal body...
  34. pmc Esophageal dysmotility in patients who have eosinophilic esophagitis
    Samuel Nurko
    Center for Motility and Functional Gastrointestinal Disorders, Children s Hospital Boston, Hunnewell Ground, 300 Longwood Avenue, Boston, MA 02115, USA
    Gastrointest Endosc Clin N Am 18:73-89; ix. 2008
    ..Some evidence suggests that treatment of EE will improve motility. Technological advances such as high-resolution manometry and combined manometry with impedance may provide new insight into more subtle motility abnormalities...
  35. ncbi Laparoscopic fundoplication: Nissen versus Toupet two-year outcome of a prospective randomized study of 200 patients regarding preoperative esophageal motility
    U Strate
    Department of General Surgery, Israelitischen Krankenhaus, Hamburg, Germany
    Surg Endosc 22:21-30. 2008
    ..We performed a randomized trial to evaluate this tailored concept and to compare the two operative techniques concerning reflux control and complication rate (dysphagia)...
  36. ncbi Effects of manometrically discovered nonspecific motility disorders of the esophagus on the outcomes of antireflux surgery
    Vic Velanovich
    Division of General Surgery K 8, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 2689, USA
    J Gastrointest Surg 8:335-41. 2004
    ..Manometrically discovered NMDs do not appear to affect preoperative symptoms or symptomatic outcomes of patients surgically treated for GERD. These findings my reflect the severity of GERD and may improve with antireflux surgery...
  37. pmc High-resolution manometry and impedance-pH/manometry: valuable tools in clinical and investigational esophagology
    Peter J Kahrilas
    Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 2951, USA
    Gastroenterology 135:756-69. 2008
    ..Ultimately, however, both technologies will be strengthened as outcome studies evaluating their utilization become available...
  38. ncbi Comparison of esophageal motility impairment caused by Chagas' disease in two age groups
    Roberto Oliveira Dantas
    Department of Internal Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Arq Gastroenterol 43:196-200. 2006
    ..Chagas' disease and the aging process cause loss of neurons of the esophageal myenteric plexus...
  39. ncbi [Pathophysiology of gastroesophageal reflux disease: motility factors]
    Katsuhiko Iwakiri
    Third Department of Internal Medicine, Nippon Medical School
    Nihon Shokakibyo Gakkai Zasshi 100:1084-94. 2003
  40. ncbi [Ineffective motility in lower third of esophagus. Length of involved esophagus and severity of gastroesophageal reflux disease]
    María Eugenia Icaza
    Laboratorio de Motilidad Gastrointestinal, Departamento de Gastroenterologia, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Seccion XVI, Tlalpan, C P 14000, Mexico, D F
    Rev Gastroenterol Mex 68:34-40. 2003
    ..Traditionally, IEM is identified by manometry at 3 and 8 cm above lower esophageal sphincter. Studies evaluating each cm of distal third of esophagus to detect IEM have not been carried out to date...
  41. ncbi Esophageal body and upper esophageal sphincter motor responses to esophageal provocation during maturation in preterm newborns
    Sudarshan Rao Jadcherla
    Section of Neonatology, Columbus Children s Hospital and Children s Research Institute, Department of Pediatrics, The Ohio State University College of Medicine and Public Health, 43205, USA
    J Pediatr 143:31-8. 2003
    ..We studied the maturation of esophageal body and upper esophageal sphincter (UES) motor responses that protect against reflux in newborns...
  42. ncbi Influence of bolus consistency and position on esophageal high-resolution manometry findings
    Anita Bernhard
    Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland
    Dig Dis Sci 53:1198-205. 2008
    ..Conventional esophageal manometry evaluating liquid swallows in the recumbent position measures pressure changes at a limited number of sites and does not assess motility during solid swallows in the physiologic upright position...
  43. ncbi Esophageal function testing: role of combined multichannel intraluminal impedance and manometry
    Radu Tutuian
    Division of Gastroenterology Hepatology, Medical University of South Carolina, 96 Jonathan Lucas Street, 210 CSB, Charleston, SC 29425, USA
    Gastrointest Endosc Clin N Am 15:265-75. 2005
    ....
  44. ncbi Preoperative esophageal manometry does not predict postoperative dysphagia following anti-reflux surgery
    S J Cole
    Department of Surgery, University of Pretoria, Pretoria, South Africa
    Dis Esophagus 18:51-6. 2005
    ..In conclusion, preoperative manometry does not predict postoperative dysphagia following laparoscopic Toupet partial fundoplication...
  45. pmc Technological insights: combined impedance manometry for esophageal motility testing-current results and further implications
    Huan Nam Nguyen
    Department of Internal Medicine, University of Technology RWTH Aachen, Germany
    World J Gastroenterol 12:6266-73. 2006
    ..However, several important issues remain to be standardized to make the technique suitable for widely clinical use...
  46. ncbi Double swallow
    Gregory N Postma
    Center for Voice and Swallowing Disorders, Department of Otolaryngology, Medical College of Georgia, Augusta, USA
    Ear Nose Throat J 85:488. 2006
  47. ncbi Effect of an acute intraluminal administration of capsaicin on oesophageal motor pattern in GORD patients with ineffective oesophageal motility
    L Grossi
    Department of Medicine and Sciences of Aging, School of Gastroenterology, c o Unit of Medicine I, Ospedale Spirito Santo, G D Annunzio University of Chieti, Pescara, Italy
    Neurogastroenterol Motil 18:632-6. 2006
    ..Whether this could represent the basis for further therapeutic approaches of GORD patients needs further study...
  48. ncbi Clinical relevance of the nutcracker esophagus: suggested revision of criteria for diagnosis
    Amit Agrawal
    Digestive Diseases Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Clin Gastroenterol 40:504-9. 2006
    ..This threshold has been selected as it exceeds the average DEA in healthy volunteers by 2 SDs. Since its introduction the clinical significance of this finding has been challenged, as many patients with NE are asymptomatic...
  49. ncbi Laparoscopic fundoplication in patients with an aperistaltic esophagus and gastroesophageal reflux
    D I Watson
    Flinders University Department of Surgery, Flinders Medical Center, Bedford Park, South Australia, Australia
    Dis Esophagus 19:94-8. 2006
    ..Patients with troublesome reflux and an aperistaltic esophagus can be effectively treated by laparoscopic fundoplication. An acceptable outcome will be achieved in the majority of patients...
  50. ncbi [Esophageal abnormalities in patients with chest pain and normal coronary angiograms]
    Sami Karoui
    Service de gastro entérologie A Hôpital la Rabta, Tunis
    Tunis Med 84:705-10. 2006
    ..To evaluate the frequency and the variety of esophageal abnormalities in patients with chest pain and normal coronary angiograms...
  51. ncbi Manometric findings in adult eosinophilic oesophagitis: a study of 12 cases
    Alfredo J Lucendo
    Department of Gastroenterology, La Paz University Hospital, Autonoma University of Madrid, Madrid, Spain
    Eur J Gastroenterol Hepatol 19:417-24. 2007
    ..To describe the manometric findings detected in adult patients with dysphagia that were diagnosed of eosinophilic oesophagitis, and to compare with the cases of eosinophilic infiltration of the oesophagus reported in the literature...
  52. ncbi Impaired esophageal function in morbidly obese patients with gastroesophageal reflux disease: evaluation with multichannel intraluminal impedance
    E Quiroga
    The Swallowing Center, Department of Surgery, University of Washington, 1959 NE Pacific Street, Box 356410, Seattle, WA 98195 6410, USA
    Surg Endosc 20:739-43. 2006
    ....
  53. ncbi Development of esophageal peristalsis in preterm and term neonates
    Annamaria Staiano
    Department of Pediatrics, University Federico II, Naples, Italy
    Gastroenterology 132:1718-25. 2007
    ..We performed high-resolution manometry in preterm and term neonates to determine the ontogenesis of esophageal motility with regard to this segmental architecture...
  54. ncbi Esophagography predicts favorable outcomes after laparoscopic Nissen fundoplication for patients with esophageal dysmotility
    Matthew J D'Alessio
    Department of Surgery, University of South Florida College of Medicine, Tampa, FL, USA
    J Am Coll Surg 201:335-42. 2005
    ..We undertook this study to determine if clearance of a food bolus at preoperative esophagography predicts acceptable outcomes after laparoscopic Nissen fundoplication for patients with manometrically abnormal esophageal motility...
  55. ncbi Does this patient have oesophageal motility abnormality or pathological acid reflux?
    S N Hong
    Division of Gastroenterology, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Dig Liver Dis 37:475-84. 2005
    ..According to their principal complaints, the patients were divided into the dysphagia category, the non-cardiac chest pain category, the gastrooesophageal reflux disease-related symptom category and the extraoesophageal symptom category...
  56. ncbi [Dilemmas arising from surgical treatment of epiphrenic diverticulum]
    Aron Altorjay
    Fejér Megyei Szent György Kórház Sebészeti Osztály, Szekesfehervar
    Orv Hetil 146:959-63. 2005
    ..Epiphrenic diverticulum cannot be considered a primary anatomical alteration, there is a manometrically verifiable motility disturbance in the background...
  57. ncbi The effect of an effortful swallow on the normal adult esophagus
    Teresa E Lever
    Department of Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Greenville, North Carolina 27858, USA
    Dysphagia 22:312-25. 2007
    ....
  58. ncbi Oesophageal high-resolution manometry: moving from research into clinical practice
    M R Fox
    Clinic for Gastroenterology and Hepatology, University Hospital Zurich, CH 4103 Zürich, Switzerland
    Gut 57:405-23. 2008
    ..Looking ahead the potential of this technology to guide more effective medical and surgical treatment of oesophageal disease is considered because, ultimately, it is this that will define the success of HRM in clinical practice...
  59. ncbi [Esophageal motor function in nonachalasia motility disorders]
    Motoyasu Kusano
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 100:1095-105. 2003
  60. ncbi Oesophageal motor and sensitivity abnormalities in non-obstructive dysphagia
    Benoit Bohn
    Département d Hépato Gastroentérologie, C H U de Grenoble, Grenoble, France
    Eur J Gastroenterol Hepatol 14:271-7. 2002
    ..To evaluate oesophageal sensitivity to balloon distension in patients with non-obstructive dysphagia (NOD), and to determine its relationship with the motility pattern in response to food ingestion...
  61. ncbi [Obesity and gastroesophageal reflux disease]
    Octavio Gómez Escudero
    Departamentos de Gastroenterología y Cirugía Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, D F
    Rev Invest Clin 54:320-7. 2002
    ..Obesity is a condition that has been associated with gastroesophageal reflux disease (GERD), however, a cause-effect relationship has not been established...
  62. ncbi Complete fundoplication has similar long-term results in patients with and without esophageal body dysmotility
    B Goss
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel 04239
    Surg Endosc 17:567-70. 2003
    ..We hypothesized that a complete floppy wrap may be just as safe in patients with poor esophageal motility...
  63. ncbi Acute food bolus impaction without stricture in children with gastroesophageal reflux
    Y Vicente
    Department of Surgery, Hospital Infantil Universitario La Paz, Madrid, Spain
    J Pediatr Surg 36:1397-400. 2001
    ..It should be differentiated from dysphagia and reveals motor dysfunction, sometimes severe, of the esophageal body in the absence of sphincteric obstruction. Antireflux medication or surgery were uniformly successful in our patients...
  64. ncbi Mechanisms of gastroesophageal reflux and gastroesophageal reflux disease
    Yvan Vandenplas
    Acacemic Children s Hospital of Brussels, Vancouber, British Columbia, Canada
    J Pediatr Gastroenterol Nutr 35:119-36. 2002
    ..In addition to development of new forms of treatment, research should address better use of currently available medical and surgical treatments...
  65. ncbi Esophageal motility in the assessment of esophageal function
    T Adhami
    Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH 44195-5164, USA
    Semin Thorac Cardiovasc Surg 13:234-40. 2001
    ..Manometry is indicated in the subset of patients with gastroesophageal reflux disease (GERD) who are being considered for antireflux surgery or have symptoms after antireflux surgery...
  66. ncbi [Primary esophageal motor disorders in childhood, genuine achalasia excluded]
    E Devouge
    Unité de Gastroentérologie, Hepatologie et nutrition, Clinique de Pediatrie, Hopital Jeanne de Flandre, 2, Avenue Oscar Lambret, 59037 Lille, France
    Arch Pediatr 9:664-70. 2002
    ..The aim of this retrospective study was to describe clinical manifestations of partial achalasia, to look for their specificities and to follow clinical and manometric evolution in response to treatment...
  67. ncbi [Nitroglycerin and angina with angiographically normal coronary vessels. Clinical effects and effects on esophageal motility]
    A Millaire
    Service de Cardiologie C, , CHR de Lille
    Arch Mal Coeur Vaiss 82:63-8. 1989
    ..abstract truncated at 250 words)..
  68. ncbi Abnormal esophageal acid exposure is common in morbidly obese patients and improves after a successful Lap-band system implantation
    P Iovino
    Dipartimento di Chirurgia Generale, Geriatrica, Oncologica e Tecnologic Avanzate e, Universita Federico II, Napoli, Italy
    Surg Endosc 16:1631-5. 2002
    ..Its indication in the presence of GERD, however, is still debated. This study aimed to investigate esophageal symptoms, motility patterns, and acid exposure in morbidly obese patients before and after LAGB placement...
  69. ncbi Oroesophageal motor disorders in Pierre Robin syndrome
    G Baujat
    Department of Pediatrics, H pital Necker-Enfants Malades, Paris, France
    J Pediatr Gastroenterol Nutr 32:297-302. 2001
    ..It could reflect dysregulation of the control of the central pattern generators of swallowing in the brain stem...
  70. ncbi Nissen vs Toupet laparoscopic fundoplication
    C Zornig
    Department of General Surgery, Israelitisches Krankenhaus, Orchideenstieg 14, 22297 Hamburg, Germany
    Surg Endosc 16:758-66. 2002
    ..Our objective was to determine the impact of preoperative esophageal motility on the clinical and objective outcome, following Toupet vs Nissen fundoplication and to evaluate the success rate of these procedures...
  71. ncbi How long should a long-term esophageal motility study be?
    S M Freys
    Department of Surgery, University of Wurzburg, Germany
    Dig Dis Sci 46:1186-93. 2001
    ..an investigation on normal volunteers (n = 10), patients with gastroesophageal reflux disease without esophageal motility disorders (n = 13), and patients with esophageal motility disorders (n = 14), a comparison was performed between ..
  72. ncbi Esophagitis-related esophageal shortening in opossum is associated with longitudinal muscle hyperresponsiveness
    R J White
    Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada K7L 3N6
    Am J Physiol Gastrointest Liver Physiol 280:G463-9. 2001
    ....
  73. ncbi Esophageal motility in reflux disease before and after fundoplication: a prospective, randomized, clinical, and manometric study
    C Fibbe
    Department of Medicine, Israelitic Hospital, Orchideenstieg 14, 22297 Hamburg, Germany
    Gastroenterology 121:5-14. 2001
    ....
  74. ncbi Fundoplication improves disordered esophageal motility
    T Ryan Heider
    Division of Gastrointestinal Surgery and Digestive Diseases, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7210, USA
    J Gastrointest Surg 7:159-63. 2003
    ..These data, along with prior data showing that postoperative dysphagia is not common, imply that surgeons should apply complete fundoplication liberally in patients with disordered preoperative esophageal motility...
  75. ncbi Influence of spastic motor disorders of the esophageal body on outcomes from laparoscopic antireflux surgery
    E R Winslow
    Department of Surgery, Washington University School of Medicine, 660 South Euclid, WUMS Box 8109, St Louis, MO 63110, USA
    Surg Endosc 17:738-45. 2003
    ..The clinical outcomes of laparoscopic antireflux surgery (LARS) in patients with the spectrum of nonspecific spastic esophageal motor disorders (NSSDs) are not known...
  76. ncbi Prospective evaluation of esophageal motor dysfunction in Down's syndrome
    N Zarate
    Radiology Department, Hospital General Vall d Hebron, Barcelona, Spain
    Am J Gastroenterol 96:1718-24. 2001
    ..The aim of this study was to determine the prevalence and way of presentation of esophageal motor dysfunction in a nonselected population of subjects with Down's syndrome...
  77. ncbi Effect of the 5-HT1 agonist sumatriptan on oesophageal motor pattern in patients with ineffective oesophageal motility
    L Grossi
    Department of Medicine and Sciences of Aging, School of Gastroenterology, c o Pierangeli Clinic, G D Annunzio University of Chieti, Pescara, Italy
    Neurogastroenterol Motil 15:9-14. 2003
    ..c. improves only the numbers but not the amplitude or propagation of oesophageal motility of patients with IOM. The 5-HT1 pathway and its acute stimulation seem to play only a minor role in the pathogenesis of such a disease...
  78. ncbi Dyskinesia of the superior oesophageal sphincter: assessment and treatment
    M Remacle
    ORL, Cliniques Universitaires UCL de Mont-Godinne, Yvoir
    Acta Otorhinolaryngol Belg 48:45-53. 1994
    ..Extramucosal myotomy of the OSS concerns incomplete or uncoordinated relaxation, preferentially by left cervical approach. The preliminary results, both clinical and manometric, are very satisfactory...
  79. ncbi Standard acid reflux testing revisited
    C G Schowengerdt
    Genesis HealthCare Systems, Zanesville, Ohio, USA
    Dig Dis Sci 46:603-5. 2001
    ..When combined with an EGD, complete testing for acid reflux disease can be performed at one setting. Further study is needed comparing dynamic acid reflux testing to 24-h pH testing...
  80. ncbi Complete fundoplication is not associated with increased dysphagia in patients with abnormal esophageal motility
    T R Heider
    Section of Gastrointestinal Surgery, Department of Surgery, University of North Carolina, Chapel Hill, NC 27599-7210, USA
    J Gastrointest Surg 5:36-41. 2001
    ....
  81. ncbi [Antireflux surgery, comperative study of three laparascopic techniques]
    Xavier Gómez Cárdenas
    Departamento de Cirugia General, Centro Medico ABC, Mexico, D F
    Rev Gastroenterol Mex 70:402-10. 2005
    ..Laparoscopic fundoplication for the surgical treatment of gastroesophageal reflux disease is widely accepted all over the world...
  82. ncbi Use of endoluminal ultrasound to evaluate gastrointestinal motility
    Larry Miller
    Temple University Hospital, Gastroenterology Section, Philadelphia, PA 19043, USA
    Dig Dis 24:319-41. 2006
    ..Various esophageal motility disorders have been investigated including achalasia, scleroderma, Barrett's esophagus and diffuse esophageal ..
  83. ncbi Combination therapy with oral sildenafil and beraprost for pulmonary arterial hypertension associated with CREST syndrome
    Kenji Miwa
    Department of Cardiology, Ishikawa Prefectural Central Hospital, Ishikawa, Japan
    Int Heart J 48:417-22. 2007
    ..Pulmonary arterial hypertension (PAH) is commonly associated with CREST (Calcinosis, Raynaud phenomenon, Esophageal motility disorders, Sclerodactyly, and Telangiectasia) syndrome...
  84. ncbi Which is the better method for location of the gastro-esophageal junction: radiography or manometry?
    K Aksglaede
    Motility Laboratory, Aarhus University Hospital, Aarhus, Denmark
    Acta Radiol 44:121-6. 2003
    ..To evaluate whether location of the gastro-esophageal junction (GEJ) could be determined with the same accuracy on radiography as by manometry with special reference to pH probe positioning...
  85. ncbi Esophageal motility disorders (distal esophageal spasm, nutcracker esophagus, and hypertensive lower esophageal sphincter): modern management
    Radu Tutuian
    Division of Gastroenterology Hepatology, University Hospital Zurich, Ramistr 100, A HOF 109, CH 8091, Zurich, Switzerland
    Curr Treat Options Gastroenterol 9:283-94. 2006
    The group of hypercontractile esophageal motility disorders includes distal esophageal spasm (DES), nutcracker esophagus (NE), and hypertensive lower esophageal sphincter (LES)...
  86. ncbi Effectiveness of esophageal manometry in predicting the outcome of children with primary GER after floppy Nissen-Rossetti wrap
    G Mattioli
    Department of Pediatric Surgery, Giannina Gaslini Research Institute, University of Genova, Italy
    Surg Endosc 18:1504-8. 2004
    ..The aim of our study was to define the effectiveness of esophageal manometry in predicting the outcome of children who need fundoplication because of refractory primary gastroesophageal reflux...
  87. ncbi Esophageal achalasia--manometric patterns
    D L Dumitrascu
    Iuliu Hatieganu University of Medicine and Pharmacy, 2nd Department of Internal Medicine, Cluj Napoca, Romania
    Rom J Intern Med 47:243-7. 2009
    ..A number of 41 patients had other esophageal motility disorders and 8 patients had normal esophageal manometry...
  88. ncbi Primary localized cutaneous nodular amyloidosis and CREST syndrome: a case report and review of the literature
    Erika M Summers
    Department of Internal Medicine, Harvard Medical Faculty Physicians, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cutis 82:55-9. 2008
    ..We report the case of a patient with PLCNA and CREST (calcinosis, Raynaud phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome...
  89. ncbi Effect of lower esophageal sphincter distension and acidification on esophageal pressure and electromyographic activity: the identification of the "sphinctero-esophageal excitatory reflex"
    Ahmed Shafik
    Department of Surgery and Experimental Research, Faculty of Medicine, Cairo University, Cairo, Egypt
    Ann Thorac Surg 79:1126-31; discussion 1131. 2005
    ..We investigated the hypothesis that lower esophageal sphincter (LES) dilatation rather than the refluxed acid affected reflex increase in the esophageal peristaltic activity aiming at clearing the esophagus of the refluxed acid...
  90. ncbi Multicenter, prospective, double-blind, randomized trial of laparoscopic nissen vs anterior 90 degrees partial fundoplication
    David I Watson
    Department of Surgery, k Flinders University of South Australia, Adelaide, Australia
    Arch Surg 139:1160-7. 2004
    ..Laparoscopic anterior 90 degrees partial fundoplication for gastroesophageal reflux is associated with a lower incidence of postoperative dysphagia and other adverse effects compared with laparoscopic Nissen fundoplication...
  91. ncbi A prospective randomized trial of laparoscopic Nissen fundoplication with anterior vs posterior hiatal repair
    D I Watson
    University of Adelaide, Department of Surgery, Royal Adelaide Hospital, South Australia 5000, Australia
    Arch Surg 136:745-51. 2001
    ..The technique used for repair of the esophageal hiatus during laparoscopic Nissen fundoplication can influence the likelihood of postoperative dysphagia...
  92. ncbi Diseases of the esophagus: diagnosis with esophagography
    Marc S Levine
    Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Radiology 237:414-27. 2005
    ..reflux disease, other types of esophagitis, benign and malignant esophageal tumors, varices, lower esophageal rings, diverticula, and esophageal motility disorders, all of which can be diagnosed with the aid of esophagography.
  93. pmc Diagnosis of chest pain with foregut symptoms in Chinese patients
    Bo Deng
    Thoracic Surgery Department, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing 400042, China
    World J Gastroenterol 15:742-7. 2009
    ..To evaluate the diagnosis of chest pain with foregut symptoms in Chinese patients...
  94. ncbi Gastrointestinal motility disorders: an update
    Brian E Lacy
    Division of Gastroenterology and Hepatology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Dig Dis 24:228-42. 2006
    ..will focus on seven of the most common gastrointestinal motility disorders (achalasia, non-achalasia esophageal motility disorders, dyspepsia, gastroparesis, chronic intestinal pseudo-obstruction, irritable bowel syndrome, and ..
  95. ncbi Pathogenesis of simultaneous esophageal contractions in patients with motility disorders
    J Behar
    Department of Medicine, Rhode Island Hospital, Providence
    Gastroenterology 105:111-8. 1993
    Simultaneous and spontaneous contractions are frequently recorded in patients with esophageal motility disorders. The aim was to investigate the pathogenesis of swallow-induced simultaneous and spontaneous contractions.
  96. ncbi [Disorders affecting the digestive system during sleep]
    A Galdón Castillo
    Hospital Universitario Virgen de las Nieves, Granada, Espana
    Rev Neurol 38:757-65. 2004
    ..tract, that is, the teeth and teeth grinding, and we then went on to look at gastroesophageal reflux, esophageal motility disorders, peptic ulcer disease, cholelithiasis, gastric ulcer, irritable bowel, proctalgia, the extent to which ..
  97. ncbi [Aplication of a 3D reconstruction model for the analysis of nitrofen induced intrathoracic malformations]
    L Martinez
    Departamentos de Cirugía Pediátrica y Anatomía Patológica, Hospital Infantil La Paz, Madrid
    Cir Pediatr 18:165-9. 2005
    ..The goal of this study is to analyse by a 3-D reconstruction software the malformations in the extrinsic innervation of the esophagus in this model...
  98. pmc New diagnostic techniques for esophageal disorders
    A Lazarescu
    Division of Gastroenterology, University of Alberta, Edmonton, Canada
    Can J Gastroenterol 22:903-8. 2008
    ..This has led to improved diagnosis of various esophageal motility disorders. Impedance measures the movement of liquid and gas in the esophagus...
  99. ncbi Endoscopic full-thickness plication (Plicator) with two serially placed implants improves esophagitis and reduces PPI use and esophageal acid exposure
    D von Renteln
    Medizinische Klinik I, Klinikum Ludwigsburg, Ludwigsburg, Germany
    Endoscopy 40:173-8. 2008
    ..In all previous studies, only a single implant was used. The aim of the present pilot study was to determine the safety and efficacy of two serially placed Plicator implants...
  100. ncbi Diffuse oesophageal spasm masking achalasia
    John Griniatsos
    Upper GI and Laparoscopic Unit, Ealing Hospital, London, United Kingdom
    Int Surg 89:32-4. 2004
    Several reports have suggested that esophageal motility disorders may progress from one type to another...
  101. ncbi Refractory heartburn to proton pump inhibitors: epidemiology, etiology and management
    Spiros N Sgouros
    Department of Gastroenterology, Athens Naval Hospital, GR 15341 Athens, Greece
    Digestion 73:218-27. 2006
    ..In such cases, compliance to therapy, duodeno-gastroesophageal reflux, gastro-esophageal motility disorders and eradication of Helicobacter pylori infection may contribute to symptoms...

Research Grants9

  1. NOVEL ESOPHAGEAL MOTOR FUNCTION ASSESSMENT SYSTEM
    JianFeng Chen; Fiscal Year: 2006
    ..Relevance: Esophageal motility disorders are seen in about 40% of clinical gastroenterology patients...
  2. An Intelligent 32-Site Esophageal Manometry System
    COLLIN RICH; Fiscal Year: 2001
    This project will develop an innovative system for analyzing esophageal motility disorders, the most prevalent of which is gastrointestinal reflux disorder (GERD)...
  3. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  4. PHARYNGEAL RECEPTORS AND REFLUX DISEASE
    RAVINDER MITTAL; Fiscal Year: 2001
    ..Effects of atropine on the frequency of TLESR and GER in patients with reflux esophagitis. ..
  5. ROLE OF PUBORECTALIS MUSCLE IN FECAL CONTINENCE
    RAVINDER MITTAL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. PLACEBO CONTROLLED STUDY OF BACLOFEN FOR GERD IN CHILDREN WITH CEREBRAL PALSY
    Samuel Nurko; Fiscal Year: 2008
    ..This study will serve as a basis to test the medication in otherwise healthy children with GERD. [unreadable] [unreadable] [unreadable]..
  7. Research Symposium on Functional Abdoninal Pain in Children
    Samuel Nurko; Fiscal Year: 2007
    ..7. To educate the NASPGHAN membership on the state of the art of functional abdominal pain and IBS in children. [unreadable] [unreadable] [unreadable]..
  8. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..These methods will be employed pre- and post-therapy on all patients to assess their potential clinical utility, especially in those unresponsive to medical therapy after aggressive acid suppression. ..