deglutition disorders

Summary

Summary: Difficulty in SWALLOWING which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the PHARYNX and UPPER ESOPHAGEAL SPHINCTER; and esophageal dysphagia due to malfunction of the ESOPHAGUS.

Top Publications

  1. ncbi The effects of lingual exercise on swallowing in older adults
    Joanne Robbins
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Am Geriatr Soc 53:1483-9. 2005
  2. pmc Alarm symptoms in early diagnosis of cancer in primary care: cohort study using General Practice Research Database
    Roger Jones
    Department of General Practice and Primary Care, Division of Health and Social Care Research, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London SE1 6SP
    BMJ 334:1040. 2007
  3. ncbi Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship
    Peter C Levendag
    Department of Radiation Oncology, Erasmus Medical Center Daniel den Hoed, Rotterdam, The Netherlands
    Radiother Oncol 85:64-73. 2007
  4. ncbi Aspiration pneumonia and dysphagia in the elderly
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 124:328-36. 2003
  5. ncbi Prevalence and prognostic implications of dysphagia in elderly patients with pneumonia
    Mateu Cabre
    Department of Internal Medicine, Hospital de Mataro, Barcelona, Spain
    Age Ageing 39:39-45. 2010
  6. pmc Alarm symptoms and identification of non-cancer diagnoses in primary care: cohort study
    Roger Jones
    Department of General Practice and Primary Care, Division of Health and Social Care Research, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London SE11 6SP
    BMJ 339:b3094. 2009
  7. ncbi Pathophysiology of oropharyngeal dysphagia in the frail elderly
    L Rofes
    Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Instituto de Salud Carlos III, Spain
    Neurogastroenterol Motil 22:851-8, e230. 2010
  8. ncbi The effects of lingual exercise in stroke patients with dysphagia
    Joanne Robbins
    William S Middleton Memorial Veterans Hospital, Geriatric Research, Education and Clinical Center, Madison, WI 53705, USA
    Arch Phys Med Rehabil 88:150-8. 2007
  9. ncbi Reliability and validity of cervical auscultation
    Christiane Borr
    Department of Clinical Linguistics, Faculty of Linguistics and Literary Studies, Bielefeld University, Germany
    Dysphagia 22:225-34. 2007
  10. ncbi Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes
    Joke Werbrouck
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 73:1187-95. 2009

Research Grants

Detail Information

Publications323 found, 100 shown here

  1. ncbi The effects of lingual exercise on swallowing in older adults
    Joanne Robbins
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Am Geriatr Soc 53:1483-9. 2005
    ..To determine the effects of an 8-week progressive lingual resistance exercise program on swallowing in older individuals, the most "at risk" group for dysphagia...
  2. pmc Alarm symptoms in early diagnosis of cancer in primary care: cohort study using General Practice Research Database
    Roger Jones
    Department of General Practice and Primary Care, Division of Health and Social Care Research, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London SE1 6SP
    BMJ 334:1040. 2007
    ..To evaluate the association between alarm symptoms and the subsequent diagnosis of cancer in a large population based study in primary care...
  3. ncbi Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: a dose-effect relationship
    Peter C Levendag
    Department of Radiation Oncology, Erasmus Medical Center Daniel den Hoed, Rotterdam, The Netherlands
    Radiother Oncol 85:64-73. 2007
    ..To assess the relationship between the radiation therapy (RT) dose received by the muscular components of the swallowing (sw) apparatus and - dysphagia related - quality of life (QoL) in oropharyngeal cancer...
  4. ncbi Aspiration pneumonia and dysphagia in the elderly
    Paul E Marik
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Chest 124:328-36. 2003
    ..This may include swallow therapy, dietary modification, aggressive oral care, and consideration for treatment with an angiotensin-converting enzyme inhibitor...
  5. ncbi Prevalence and prognostic implications of dysphagia in elderly patients with pneumonia
    Mateu Cabre
    Department of Internal Medicine, Hospital de Mataro, Barcelona, Spain
    Age Ageing 39:39-45. 2010
    ..oropharyngeal dysphagia is a common condition among the elderly but not systematically explored...
  6. pmc Alarm symptoms and identification of non-cancer diagnoses in primary care: cohort study
    Roger Jones
    Department of General Practice and Primary Care, Division of Health and Social Care Research, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London SE11 6SP
    BMJ 339:b3094. 2009
    ..To evaluate the predictive value of alarm symptoms for specified non-cancer diagnoses and cancer diagnoses in primary care...
  7. ncbi Pathophysiology of oropharyngeal dysphagia in the frail elderly
    L Rofes
    Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Instituto de Salud Carlos III, Spain
    Neurogastroenterol Motil 22:851-8, e230. 2010
    ..Oropharyngeal dysphagia is a major complaint among the elderly. Our aim was to assess the pathophysiology of oropharyngeal dysphagia in frail elderly patients (FEP)...
  8. ncbi The effects of lingual exercise in stroke patients with dysphagia
    Joanne Robbins
    William S Middleton Memorial Veterans Hospital, Geriatric Research, Education and Clinical Center, Madison, WI 53705, USA
    Arch Phys Med Rehabil 88:150-8. 2007
    ..To examine the effects of lingual exercise on swallowing recovery poststroke...
  9. ncbi Reliability and validity of cervical auscultation
    Christiane Borr
    Department of Clinical Linguistics, Faculty of Linguistics and Literary Studies, Bielefeld University, Germany
    Dysphagia 22:225-34. 2007
    ....
  10. ncbi Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes
    Joke Werbrouck
    Department of Basic Medical Sciences, Ghent University, Ghent, Belgium
    Int J Radiat Oncol Biol Phys 73:1187-95. 2009
    ..1843A>G, c.562-14A>G, c.722C>T), Rad51 (c.-3429G>C, c.-3392G>T), Lig4 (c.26C>T, c.1704T>C), Ku70 (c.-1310C>G), and Ku80 (c.2110-2408G>A) and the occurrence of acute reactions after radiotherapy...
  11. ncbi Viscosity and non-Newtonian features of thickened fluids used for dysphagia therapy
    Mark O'Leary
    Dept of Mechanical Engineering, University College London, Torrington Place, London, UK
    J Food Sci 75:E330-8. 2010
    ..This research aims to further understanding of the flow properties of thickened drinks and bring a quantified measure of thickness closer to being a practical reality...
  12. ncbi An acoustic profile of normal swallowing
    Scott R Youmans
    Department of Communication Sciences and Disorders, Long Island University, Brooklyn Campus, 1 University Plaza, Brooklyn, NY 11201, USA
    Dysphagia 20:195-209. 2005
    ..These results could serve as a reference point for future studies into normal swallowing across multiple bolus consistencies and volumes and eventually be compared with disordered swallowing...
  13. ncbi Relationship between swallowing problems and tooth loss in community-dwelling independent elderly adults: the Fujiwara-kyo study
    Nozomi Okamoto
    Department of Community Health and Epidemiology, Nara Medical University, Nara, Japan
    J Am Geriatr Soc 60:849-53. 2012
    ..To investigate the relationship between swallowing problems and the number of remaining teeth in healthy elderly people...
  14. ncbi Reduced tongue pressure against the hard palate on the paralyzed side during swallowing predicts Dysphagia in patients with acute stroke
    Nobuko Hirota
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan
    Stroke 41:2982-4. 2010
    ..The present study investigated the relationship between tongue motor deficits and dysphagia in patients with acute stroke...
  15. ncbi Targeting unlesioned pharyngeal motor cortex improves swallowing in healthy individuals and after dysphagic stroke
    Emilia Michou
    School of Translational Medicine Inflammation Sciences, University of Manchester part of the Manchester Academic Health Sciences Centre, Salford Royal Hospital, Salford, England
    Gastroenterology 142:29-38. 2012
    ....
  16. ncbi Formal dysphagia screening protocols prevent pneumonia
    Judith A Hinchey
    Department of Neurology, Saint Elizabeth s Medical Center, Boston, MA, USA
    Stroke 36:1972-6. 2005
    ..Five guidelines recommend a dysphagia screen before oral intake. What constitutes an adequate dysphagia screen and which patients should receive it remain unclear...
  17. pmc Role of videofluoroscopy in evaluation of neurologic dysphagia
    M G Rugiu
    Otorhinolaryngology Unit, Universiy Hospital S ta Maria della Misericordia, Udine, Italy
    Acta Otorhinolaryngol Ital 27:306-16. 2007
    ....
  18. pmc Aspiration and swallowing in Parkinson disease and rehabilitation with EMST: a randomized trial
    M S Troche
    PO Box 117420, University of Florida, Gainesville, FL 32611, USA
    Neurology 75:1912-9. 2010
    ..The current study's objective was to test the treatment outcome of a 4-week device-driven EMST program on swallow safety and define the physiologic mechanisms through measures of swallow timing and hyoid displacement...
  19. ncbi Electrical stimulation for swallowing disorders caused by stroke
    M L Freed
    Respiratory Care Department, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland OH 44106, USA
    Respir Care 46:466-74. 2001
    ..We describe an alternative treatment consisting of transcutaneous electrical stimulation (ES) applied through electrodes placed on the neck...
  20. ncbi Swallowing dysfunction--preventative and rehabilitation strategies in patients with head-and-neck cancers treated with surgery, radiotherapy, and chemotherapy: a critical review
    Bharat B Mittal
    Department of Radiology, Section of Radiation Oncology, Northwestern University Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA
    Int J Radiat Oncol Biol Phys 57:1219-30. 2003
  21. ncbi Analysis of the relations between the shape of the reconstructed tongue and postoperative functions after subtotal or total glossectomy
    Yoshihiro Kimata
    Division of Plastic and Reconstructive Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    Laryngoscope 113:905-9. 2003
    ..The objective was to investigate the relations of the shape of the reconstructed tongue to postoperative swallowing and speech functions...
  22. pmc Dysphagia in the elderly: management and nutritional considerations
    Livia Sura
    Swallowing Research Laboratory, College of Public Health and Health Professions, Gainesville, FL, USA
    Clin Interv Aging 7:287-98. 2012
    ..We conclude with a discussion on the positive impact of swallowing rehabilitation on malnutrition and pneumonia in elderly who either present with dysphagia or are at risk for dysphagia...
  23. ncbi The rheology of liquids: a comparison of clinicians' subjective impressions and objective measurement
    Catriona M Steele
    Oral Dynamics Laboratory, Graduate Department of Speech Language Pathology, University of Toronto, Toronto, Ontario, Canada
    Dysphagia 18:182-95. 2003
    ..Physical sampling of these two products enabled clinicians to reliably perceive relative viscosity and density differences between the nectar- and honey-thick items...
  24. ncbi Assessment of pediatric dysphagia and feeding disorders: clinical and instrumental approaches
    Joan C Arvedson
    Children s Hospital of Wisconsin Milwaukee, Medical College of Wisconsin Milwaukee, Milwaukee, Wisconsin, USA
    Dev Disabil Res Rev 14:118-27. 2008
    ..Successful oral feeding must be measured in quality of meal time experiences with best possible oral sensorimotor skills and safe swallowing while not jeopardizing a child's functional health status or the parent-child relationship...
  25. ncbi Dysphagia following chemoradiation for locally advanced head and neck cancer
    N P Nguyen
    Radiation Oncology, VA North Texas Health Care System, Dallas 75216, USA
    Ann Oncol 15:383-8. 2004
    ..To assess the prevalence, severity and morbidity of dysphagia following concurrent chemoradiation for head and neck cancer...
  26. ncbi Tongue movements during water swallowing in healthy young and older adults
    Catriona M Steele
    Toronto Rehabilitation Institute, Toronto, Ontario, Canada
    J Speech Lang Hear Res 52:1255-67. 2009
    ..In addition, changes were quantified in healthy tongue movements in response to specific differences in the nature of the swallowing task (discrete vs. sequential swallows)...
  27. ncbi Quantifying fluid intake in dysphagic stroke patients: a preliminary comparison of oral and nonoral strategies
    H M Finestone
    Department of Physical Medicine and Rehabilitation, University of Ottawa, Sisters of Charity Health Sciences Service, Ottawa, Ontario, Canada
    Arch Phys Med Rehabil 82:1744-6. 2001
    ..To determine whether dysphagic stroke patients receiving oral (thickened-fluid dysphagia) diets or nonoral (enteral feedings supplemented with intravenous fluids) diets met their estimated fluid requirements...
  28. ncbi Videofluoroscopic studies of swallowing dysfunction and the relative risk of pneumonia
    Lana Pikus
    Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia 19104, USA
    AJR Am J Roentgenol 180:1613-6. 2003
    ..The purpose of our investigation was to determine the relationship between the degree of swallowing dysfunction observed on barium studies and the likelihood of developing pneumonia in a large series of patients...
  29. ncbi Effect of citric acid and citric acid-sucrose mixtures on swallowing in neurogenic oropharyngeal dysphagia
    Cathy A Pelletier
    Department of Food Science and Technology, Cornell University, Ithaca, New York, USA
    Dysphagia 18:231-41. 2003
    ..The mechanisms for improved swallowing due to citric acid are not understood but may be due to increased gustatory and trigeminal stimulation of acid to the brainstem in neurologically impaired subjects...
  30. ncbi Social and psychological burden of dysphagia: its impact on diagnosis and treatment
    Olle Ekberg
    Department of Diagnostic Radiology, Malmo University Hospital, Sweden
    Dysphagia 17:139-46. 2002
    ..Awareness of the condition, diagnostic procedures, and treatment options must be increased in society and among the medical profession...
  31. ncbi Accuracy of the volume-viscosity swallow test for clinical screening of oropharyngeal dysphagia and aspiration
    Pere Clave
    Unitat d Exploracions Funcionals Digestives, Department of Surgery, Hospital de Mataro, Universitat Autonoma de Barcelona, Carretera de Cirera s n, 08304 Mataró, Spain
    Clin Nutr 27:806-15. 2008
    ..To determine the accuracy of the bedside volume-viscosity swallow test (V-VST) for clinical screening of impaired safety and efficacy of deglutition...
  32. ncbi Validity and reliability of the Eating Assessment Tool (EAT-10)
    Peter C Belafsky
    Center for Voice and Swallowing, Department of Otolaryngology Head and Neck Surgery, University of California Davis, 2521 Stockton Blvd, Suite 7200, Sacramento, CA 95825, USA
    Ann Otol Rhinol Laryngol 117:919-24. 2008
    ..The Eating Assessment Tool is a self-administered, symptom-specific outcome instrument for dysphagia. The purpose of this study was to assess the validity and reliability of the 10-item Eating Assessment Tool (EAT-10)...
  33. ncbi Validation in French of the SWAL-QOL scale in patients with oropharyngeal dysphagia
    E Khaldoun
    Service de physiologie digestive urinaire respiratoire et sportive, Rouen University Hospital, 76031 Rouen, France
    Gastroenterol Clin Biol 33:167-71. 2009
    ..This study also demonstrated the linguistic and psychometric validity of the French version of the SWAL-QOL questionnaire...
  34. pmc A randomized study of three interventions for aspiration of thin liquids in patients with dementia or Parkinson's disease
    Jeri A Logemann
    Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, 3 358, Evanston, IL 60208, USA
    J Speech Lang Hear Res 51:173-83. 2008
    ....
  35. ncbi Effects of functional training of dysphagia to prevent pneumonia for patients on tube feeding
    Koichiro Ueda
    Division of Dysphagia Rehabilitation, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Gerodontology 21:108-11. 2004
    ..The purpose of this study was to evaluate the effects of functional training on outbreak frequency of pneumonia for the elderly dysphagia patients who were being tube fed...
  36. ncbi Evaluation of oropharyngeal dysphagia: which diagnostic tool is superior?
    Susan E Langmore
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, USA
    Curr Opin Otolaryngol Head Neck Surg 11:485-9. 2003
    ....
  37. ncbi The validation of the Chinese version of the Swallow Quality-of-Life Questionnaire (SWAL-QOL) using exploratory and confirmatory factor analysis
    Pui Mei Lam
    The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
    Dysphagia 26:117-24. 2011
    ..It is a clinically valid and reliable tool for assessing the quality of life in dysphagic Chinese patients in Hong Kong, regardless of the causes of dysphagia...
  38. ncbi Effects of treatment intensification on acute local toxicity during radiotherapy for head and neck cancer: prospective observational study validating CTCAE, version 3.0, scoring system
    Mauro Palazzi
    Unit of Radiotherapy, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 70:330-7. 2008
    ..0 (CTCAE v3.0), scoring system...
  39. ncbi Late swallowing dysfunction and dysphagia after radiotherapy for pharynx cancer: frequency, intensity and correlation with dose and volume parameters
    Kenneth Jensen
    Department of Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 85:74-82. 2007
    ..The aim of the current study was to describe swallowing function after radiotherapy and examine its correlation with irradiated volume and dose...
  40. ncbi The influence of orolingual pressure on the timing of pharyngeal pressure events
    Catriona M Steele
    Toronto Rehabilitation Institute, Toronto, Canada
    Dysphagia 22:30-6. 2007
    ....
  41. pmc Adult-onset dysphagia lusoria secondary to a dissecting aberrant right subclavian artery associated with type B acute aortic dissection
    Sarabjeet Singh
    Department of Medicine, Division of Cardiology, Chicago Medical School North Chicago Veterans Administration Medical Center, Chicago, Illinois 60064, USA
    Can J Cardiol 24:63-5. 2008
    ..Because the patient had multiple underlying comorbidities and the dysphagia was mild and intermittent, surgery was deferred. The patient was discharged home after complete stabilization and was scheduled for a follow-up appointment...
  42. ncbi Reliability and validity of cervical auscultation: a controlled comparison using videofluoroscopy
    Paula Leslie
    School of Surgical and Reproductive Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Dysphagia 19:231-40. 2004
    ..The group consensus correctly identified 17 of the 20 clips so we may speculate that the swallow sound contains audible cues that should in principle permit reliable classification...
  43. ncbi Utility of clinical swallowing examination measures for detecting aspiration post-stroke
    G H McCullough
    University of Arkansas for Medical Sciences Medical Center, Little Rock 72205, USA
    J Speech Lang Hear Res 48:1280-93. 2005
    ..At present, there are no data to suggest that CSEs can be used to quantify aspiration or make adequate recommendations regarding patient care...
  44. ncbi Prevalence of perceived dysphagia and quality-of-life impairment in a geriatric population
    Po Hung Chen
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Dysphagia 24:1-6. 2009
    ..Finally, individuals may inaccurately ascribe swallowing problems to normal aging, supporting the role of community education about dysphagia in the elderly...
  45. pmc Dysphagia in the elderly
    Ianessa A Humbert
    Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 98 North Broadway, Suite 413, Baltimore, MD 21231, USA
    Phys Med Rehabil Clin N Am 19:853-66, ix-x. 2008
    ..Upward of 40% of people in institutionalized settings are dysphagic. There is a need to address dysphagia in ambulatory, acute care, and long-term care settings...
  46. pmc Postsurgical recurrence of osteophytes causing dysphagia in patients with diffuse idiopathic skeletal hyperostosis
    Kei Miyamoto
    Department of Orthopaedic Surgery, Gifu University School of Medicine, Gifu 500 1194, Japan
    Eur Spine J 18:1652-8. 2009
    ..Therefore, attending surgeons should continue to follow these patients postoperatively for more than 10 years in order to assess the regrowth of osteophytes that may contribute to recurrent symptoms...
  47. ncbi Predicting aspiration after hemispheric stroke from timing measures of oropharyngeal bolus flow and laryngeal closure
    Maxine L Power
    Department of Rehabilitation and Human Performance Research, University of Salford, Salford, Greater Manchester M5 4WT, UK
    Dysphagia 24:257-64. 2009
    ..These measurements, if translatable into clinical bedside evaluation, may assist with the development of novel measurement and intervention techniques to detect and treat poststroke aspiration...
  48. ncbi Oropharyngeal aspiration and pneumonia in children
    Kelly Weir
    Department of Paediatrics and Child Health, University of Queensland, Herston, Queensland, Australia
    Pediatr Pulmonol 42:1024-31. 2007
    ..We conclude that the impact of OPA on development of pneumonia is considerably reduced once other factors in children with multisystem involvement are taken into account...
  49. pmc Improvements in tongue strength and pressure-generation precision following a tongue-pressure training protocol in older individuals with dysphagia: three case reports
    Erin M Yeates
    Toronto Rehabilitation Institute, 550 University Avenue, 11th Floor, Toronto, ON, M5G 2A2, Canada
    Clin Interv Aging 3:735-47. 2008
    ..The experimental treatment protocol holds promise as a rehabilitative tool for various dysphagia populations...
  50. ncbi The effectiveness of targeted feeding assistance to improve the nutritional intake of elderly dysphagic patients in hospital
    L Wright
    Department of Nutrition and Dietetics, Imperial College Healthcare NHS Trust, Charing Cross Hospital, Fulham Palace Road, London, UK
    J Hum Nutr Diet 21:555-62; quiz 564-5. 2008
    ..Dysphagic older patients are prescribed texture modified food or fluids as treatment. The present study aimed to determine whether targeted feeding assistance using trained volunteers increased oral intake in elderly dysphagic patients...
  51. ncbi Failure of self-expanding plastic stents in treatment of refractory benign esophageal strictures
    S L Triester
    Division of Gastroenterology and Hepatology, Mayo Clinic, Arizona, Scottsdale, Arizona 85259, USA
    Endoscopy 38:533-7. 2006
  52. ncbi Managing dysphagia in older people with dementia
    Gaye Kyle
    Thames Valley University
    Br J Community Nurs 16:6-10. 2011
    ..Food and drink are fundamental to living. Consequently observing individuals struggling with eating and drinking not only poses difficulties for professionals but also raises emotional issues for the individual and their family...
  53. ncbi The coordination of breathing and swallowing in Parkinson's disease
    Roxann Diez Gross
    Division of Otolaryngology, University of Pittsburgh, Eye and Ear Institute, Suite 500, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Dysphagia 23:136-45. 2008
    ..The high incidence of oropharyngeal dysphagia and risk of aspiration pneumonia found in Parkinson's disease patients may be partially attributable to impaired coordination of breathing and swallowing...
  54. pmc Senescent swallowing: impact, strategies, and interventions
    Denise M Ney
    University of Wisconsin, Department of Nutritional Sciences, and the William S Middleton Memorial VA Hospital GRECC, 2500 Overlook Terrace, GRECC 11G, Madison, WI 53705, USA
    Nutr Clin Pract 24:395-413. 2009
    ....
  55. ncbi Temporal measurements of pharyngeal swallowing in normal populations
    Youngsun Kim
    School of Hearing, Speech and Language Sciences, College of Health and Human Services, Ohio University, Athens, Ohio 45701 2979, USA
    Dysphagia 20:290-6. 2005
    ..No gender differences were observed. These data on normal subjects will be used for comparisons with stroke patients in future research...
  56. ncbi McNeill dysphagia therapy program: a case-control study
    Giselle D Carnaby-Mann
    Department of Behavioral Science and Community Health, University of Florida Health Center, University of Florida, Gainesville, FL 32610, USA
    Arch Phys Med Rehabil 91:743-9. 2010
    ....
  57. ncbi Botulinum toxin assessment, intervention and aftercare for paediatric and adult drooling: international consensus statement
    D Reddihough
    Developmental Medicine, Royal Children s Hospital, Parkville, Victoria, Australia
    Eur J Neurol 17:109-21. 2010
    ..BoNT-A is usually well tolerated, although potential side effects should be discussed with the patient and carer...
  58. ncbi Effects of therapy for dysphagia in Parkinson's disease: systematic review
    Laura W J Baijens
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Dysphagia 24:91-102. 2009
    ..Further research based on randomized controlled trials to determine the effectiveness of different therapies for dysphagia in Parkinson's disease is required...
  59. ncbi Pediatric dysphagia
    Maureen A Lefton-Greif
    Department of Pediatrics, Eudowood Division of Pediatric Respiratory Sciences, The Johns Hopkins University School of Medicine, The David M Rubenstein Child Health Building, Baltimore, MD 21287, USA
    Phys Med Rehabil Clin N Am 19:837-51, ix. 2008
    ....
  60. ncbi Is drooling secondary to a swallowing disorder in patients with Parkinson's disease?
    Ana Caline Nóbrega
    Division of Neurology and Epidemiology, Federal University of Bahia, Brazil
    Parkinsonism Relat Disord 14:243-5. 2008
    ..The results showed a correlation between the drooling scale score and the level of dysphagia (-0.426; p<0.05). Patients with the worst dysphagia had the worst drooling...
  61. ncbi An overview of pediatric dysphagia
    Jane E Prasse
    Department of Speech Language Pathology and Audiology, Steinhardt School of Culture, Education and Human Development, New York University, New York, NY 10003, USA
    Clin Pediatr (Phila) 48:247-51. 2009
    ..This article provides a review of symptoms, etiologies, and resources available regarding management of this condition to help the primary care physician and the families of young children and infants in its management...
  62. ncbi Long-term follow-up of oropharyngeal dysphagia in children without apparent risk factors
    Maureen A Lefton-Greif
    Eudowood Division of Pediatric Respiratory Sciences at Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Pediatr Pulmonol 41:1040-8. 2006
    ..Early identification and prompt initiation of appropriate treatments are critical for reduction of morbidities associated with dysphagia...
  63. ncbi Removable, fully covered, self-expandable metal stents for the treatment of refractory benign esophagogastric anastomotic strictures
    Jingeng Liu
    Department of Thoracic Oncology, Cancer Center, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou, People s Republic of China
    Dysphagia 27:260-4. 2012
    ..Given that effective methods for treating refractory stricture have not been found, RFCSEMSs could be considered for treating refractory benign esophagogastric anastomotic stricture...
  64. ncbi Pretreatment, preoperative swallowing exercises may improve dysphagia quality of life
    Brian Daniel Kulbersh
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Laryngoscope 116:883-6. 2006
    ..Traditional dysphagia management strategies focus on post-treatment therapy. This study evaluated the utility of pretreatment swallowing exercises in improving post-treatment swallowing quality of life (QOL)...
  65. pmc Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results
    Felix Y Feng
    Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    J Clin Oncol 28:2732-8. 2010
    ..To assess clinical and functional results of chemoradiotherapy for oropharyngeal cancer (OPC), utilizing intensity-modulated radiotherapy (IMRT) to spare the important swallowing structures to reduce post-therapy dysphagia...
  66. ncbi Chewing and food consistency: effects on bolus transport and swallow initiation
    Eiichi Saitoh
    Department of Rehabilitation Medicine, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    Dysphagia 22:100-7. 2007
    ..Consuming two-phase foods with both solid and liquid phases may increase the risk of aspiration in dysphagic individuals with impaired airway protective reflexes...
  67. ncbi Neuroleptic-induced dysphagia: case report and literature review
    Rainer Dziewas
    Department of Neurology, University Hospital of Munster, Munster, Germany
    Dysphagia 22:63-7. 2007
    ..After changing medication to fluphenazin, dysphagic symptoms resolved. The literature on EPS-related dysphagia, its demographic features, typical symptoms, diagnostic modalities, clinical course, and treatment options is reviewed...
  68. pmc Swallowing disorders in the first year after radiation and chemoradiation
    Jeri A Logemann
    Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois, USA
    Head Neck 30:148-58. 2008
    ..Radiation alone or concurrent chemoradiation can result in severe swallowing disorders. This manuscript defines the swallowing disorders occurring at pretreatment and 3 and 12 months after completion of radiation or chemoradiation...
  69. ncbi Swallowing dysfunction after chemoradiation for advanced squamous cell carcinoma of the head and neck
    Tamar Kotz
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Head Neck 26:365-72. 2004
    ..Swallowing dysfunction is a common side effect of chemoradiation...
  70. ncbi High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry
    M Fox
    Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
    Neurogastroenterol Motil 16:533-42. 2004
    ..ii) The clinical value of HRM was assessed in a series of patients with endoscopy-negative dysphagia in whom conventional investigations had been non-diagnostic...
  71. ncbi Three tests for predicting aspiration without videofluorography
    Haruka Tohara
    Department of Rehabilitation Medicine, Fujita Health University, Aichi, Japan
    Dysphagia 18:126-34. 2003
    ..These non-VFG tests have limitations but may be useful for assessing patients when VFSS is not feasible. They may also be useful as screening procedures to determine which dysphagia patients need a VFSS...
  72. ncbi Standard values of maximum tongue pressure taken using newly developed disposable tongue pressure measurement device
    Yuri Utanohara
    Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, 734 8553, Japan
    Dysphagia 23:286-90. 2008
    ..It may be concluded that maximum tongue pressures were reduced with primary aging. Males may become weaker with age at a faster rate than females; however, further decreases in strength were in parallel for male and female subjects...
  73. ncbi Thickened liquids: practice patterns of speech-language pathologists
    Jane Mertz Garcia
    Program in Communication Science and Disorders, Kansas State University, Manhattan 66506 1403, USA
    Am J Speech Lang Pathol 14:4-13. 2005
    ..Results highlight issues related to products and staff training, as well as perceptions concerning the factors that might affect patients' acceptance of and compliance with use of the products...
  74. ncbi Effects of decreasing endotracheal tube cuff pressures during neck retraction for anterior cervical spine surgery
    Jebadurai Ratnaraj
    Department of Anesthesiology, Washington University School of Medicine, Saint Louis, Missouri, USA
    J Neurosurg 97:176-9. 2002
    ....
  75. ncbi The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reliability and validity
    Colleen A McHorney
    Roudebush VA Medical Center, Department of Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, USA
    Dysphagia 17:97-114. 2002
    ....
  76. ncbi Screening swallowing function of patients with acute stroke. Part two: Detailed evaluation of the tool used by nurses
    L Perry
    Mayday Healthcare NHS Trust and Faculty of Health and Social Care Sciences, Kingston University St George s Hospital Medical School, Kingston upon Thames, Surrey, UK
    J Clin Nurs 10:474-81. 2001
    ..As a component of evidence-based guidelines for nutritional support in acute stroke, the screening initiative contributed to improved patient outcomes...
  77. ncbi Dysphagia in head and neck cancer patients treated with radiation: assessment, sequelae, and rehabilitation
    Barbara A Murphy
    Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232 6307, USA
    Semin Radiat Oncol 19:35-42. 2009
    ....
  78. ncbi Videofluoroscopic assessment of patients with dysphagia: pharyngeal retention is a predictive factor for aspiration
    Edith Eisenhuber
    Department of Radiology and Ludwig Boltzmann Institute for Clinical and Experimental Radiologic Research, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    AJR Am J Roentgenol 178:393-8. 2002
    ..This study evaluated the clinical significance of pharyngeal retention to predict aspiration in patients with dysphagia...
  79. ncbi Clinical utility of the modified barium swallow
    B Martin-Harris
    The Evelyn Trammell Voice and Swallowing Center, Saint Joseph s Hospital of Atlanta, Atlanta, Georgia 30342, USA
    Dysphagia 15:136-41. 2000
    ....
  80. ncbi Incidence of dysphagia after anterior cervical spine surgery: a prospective study
    Rajesh Bazaz
    Spine Institute and Department of Orthopaedic Surgery, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Spine (Phila Pa 1976) 27:2453-8. 2002
    ..A prospective longitudinal study was conducted to evaluate dysphagia after anterior cervical spine surgery...
  81. ncbi Electrophysiological evaluation of pharyngeal phase of swallowing in patients with Parkinson's disease
    Cumhur Ertekin
    Department of Neurology, Ege University Medical School Hospital, Bornova, Izmir, Turkey
    Mov Disord 17:942-9. 2002
    ..Similarly, the swallowing problems of PD are not only related with the dopamine deficiency; some other nondopaminergic mechanisms may also be involved...
  82. ncbi Dysphagia after anterior cervical decompression and fusion: prevalence and risk factors from a longitudinal cohort study
    Lee H Riley
    Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Spine (Phila Pa 1976) 30:2564-9. 2005
    ..Retrospective analysis of the incidence and prevalence of dysphagia after anterior cervical decompression and fusion (ACDF)...
  83. pmc Comparison of 2 interventions for liquid aspiration on pneumonia incidence: a randomized trial
    Joanne Robbins
    William S Middleton Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, and University of Wisconsin, Madison, Wisconsin 53705, USA
    Ann Intern Med 148:509-18. 2008
    ..Aspiration pneumonia is common among frail elderly persons with dysphagia. Although interventions to prevent aspiration are routinely used in these patients, little is known about the effectiveness of those interventions...
  84. ncbi Impact of swallowing therapy on aspiration rate following treatment for locally advanced head and neck cancer
    Nam P Nguyen
    Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA
    Oral Oncol 43:352-7. 2007
    ..However, a significant number of patients still suffered from chronic severe aspiration. New strategies must be devised to improve their outcome...
  85. ncbi The evaluation of dysphagia following radical surgery for oral and pharyngeal carcinomas by cine-magnetic resonance imaging (Cine-MRI)
    Hiroya Kitano
    Department of Otolaryngology, Head and Neck Surgery, Shiga University of Medical Science, Otsu, Japan
    Dysphagia 17:187-91. 2002
    ..These variables were markedly different in patients with dysphagia than they were in healthy controls. Cine-MRI not only provides dynamic images of swallowing but can generate objective measures of swallowing ability as well...
  86. ncbi Aspiration with dysphagia: the interaction between oropharyngeal and respiratory impairments
    Richard Morton
    Department of Paediatrics, Ronnie MacKeith Child Development Centre, Derbyshire Children s Hospital, Derby, United Kingdom
    Dysphagia 17:192-6. 2002
    ..Aspiration results from oropharyngeal impairments with inadequate respiratory integration. Further research is needed to investigate whether intervention to improve respiratory control can reduce aspiration in people with dysphagia...
  87. ncbi Self-expanding metal esophageal stent with anti-reflux mechanism
    K S Dua
    M.C.W. Dysphagia Institute, Medical College of Wisconsin and V.A. Medical Center, Milwaukee, USA
    Gastrointest Endosc 53:603-13. 2001
    ..Karnofsky performance status scale did not improve significantly. CONCLUSIONS: The efficacy of the modified stent in relieving dysphagia is comparable with a standard stent. It also effectively prevents gastroesophageal reflux...
  88. ncbi Neuromuscular electrical stimulation (NMES) in stroke patients with oral and pharyngeal dysfunction
    Margareta Bülow
    Diagnostic Centre of Imaging and Functional Medicine, Malmo University Hospital, Malmo, Sweden
    Dysphagia 23:302-9. 2008
    ..The correlations between measurements were low. The patient's subjective experience of improvement had low correlation with the outcome from the objective evaluation...
  89. ncbi Dysphagia in a patient with lateral medullary syndrome: insight into the central control of swallowing
    R Martino
    Department of Speech Language Pathology, Toronto Western Hospital, University Health Network, Fell Pavilion 4th Floor, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
    Gastroenterology 121:420-6. 2001
    ..This case provides insight into the central control of swallowing...
  90. ncbi Dysphagia after stroke: incidence, diagnosis, and pulmonary complications
    Rosemary Martino
    Graduate Department of Speech Language Pathology, University of Toronto, Ontario, Canada
    Stroke 36:2756-63. 2005
    ..To determine the incidence of dysphagia and associated pulmonary compromise in stroke patients through a systematic review of the published literature...
  91. ncbi Comparison of effortful and noneffortful swallows in healthy middle-aged and older adults
    J A Hind
    Department of Medicine, University of Wisconsin Madison, USA
    Arch Phys Med Rehabil 82:1661-5. 2001
    ..To assess the effects of effortful swallowing, a common compensatory strategy for dysphagia, on the bolus and swallowing mechanism of middle-aged and older men and women...
  92. ncbi National Institutes of Health stroke scale assists in predicting the need for percutaneous endoscopic gastrostomy tube placement in acute ischemic stroke
    Amer Alshekhlee
    Neurological Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106 5040, USA
    J Stroke Cerebrovasc Dis 19:347-52. 2010
    ..These findings may have benefits in terms of early decision making, shorter hospitalization, and possible cost savings...
  93. ncbi Effects of bolus consistency on timing and safety of swallow in patients with Parkinson's disease
    Michelle S Troche
    Department of Communication Sciences and Disorders, University of Florida, Gainesville, PO Box 117420, Florida 32611, USA
    Dysphagia 23:26-32. 2008
    ..The results demonstrated various significant differences and relationships among the dependent variables. Implications for further research and clinical practice are discussed...
  94. ncbi Oropharyngeal dysphagia in infants and children with infantile Pompe disease
    Harrison N Jones
    Division of Speech Pathology and Audiology, Department of Surgery, Duke University, 155 Baker House, Trent Drive, DUMC 3887, Durham, NC 27710, USA
    Dysphagia 25:277-83. 2010
    ..9% of subjects, including penetration in five (38.46%) and silent aspiration in an additional five (38.46%). No relationship in the relative involvement of swallowing, gross motor function, and cardiac disease appeared to be present...
  95. ncbi Prospective evaluation of quality of life and nutrition before and after treatment for nasopharyngeal carcinoma
    Justine E Oates
    Sydney Head and Neck Cancer Institute, Level 6, Gloucester House, Royal Prince Alfred Hospital, Missenden Road, Camperdown, Sydney, New South Wales 2047, Australia
    Arch Otolaryngol Head Neck Surg 133:533-40. 2007
    ..Concurrent chemoradiotherapy is standard for advanced nasopharyngeal cancer; however, the toxic effects of this treatment are substantial...
  96. ncbi Movement of the hyoid bone and the epiglottis during swallowing in patients with dysphagia from different etiologies
    Nam Jong Paik
    Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi dong Bundang gu, Seongnam 463 707, Republic of Korea
    J Electromyogr Kinesiol 18:329-35. 2008
    ....
  97. ncbi Screening for dysphagia and aspiration in acute stroke: a systematic review
    L Perry
    Mayday Healthcare, Faculty of Health and Social Care Sciences, Kingston University and St George s Hospital Medical School, Kingston upon Thames, Surrey, England
    Dysphagia 16:7-18. 2001
    ..While studies indicate current "best practice," in this important area of patient care further work is urgently required...
  98. ncbi Risk factors for chest infection in acute stroke: a prospective cohort study
    Cameron Sellars
    Academic Section of Geriatric Medicine, Glasgow Royal Infirmary, Glasgow, UK
    Stroke 38:2284-91. 2007
    ..Pneumonia is a major cause of morbidity and mortality after stroke. We aimed to determine key characteristics that would allow prediction of those patients who are at highest risk for poststroke pneumonia...
  99. ncbi Consequence of dysphagia in the hospitalized patient: impact on prognosis and hospital resources
    Kenneth W Altman
    Department of Otolaryngology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY 10029, USA
    Arch Otolaryngol Head Neck Surg 136:784-9. 2010
    ..Dysphagia is increasingly prevalent with age and comorbid medical conditions. Our research group has previously shown that dysphagia is a bad prognostic indicator in patients with stroke...
  100. ncbi Dysphagic independent feeders' justifications for noncompliance with recommendations by a speech-language pathologist
    Nancy Colodny
    Department of Speech, Communication Sciences, and Theater, Graduate School of Arts and Sciences, St John s University, Jamaica, NY 11439, USA
    Am J Speech Lang Pathol 14:61-70. 2005
    ..Implications were drawn for SLP practice in dealing with noncompliant independent-feeding patients with dysphagia...
  101. ncbi Cross-cultural adaptation and validation of the Dutch version of SWAL-QoL
    H C A Bogaardt
    Department of Otorhinolaryngology D2 313, Academic Medical Center, Amsterdam, The Netherlands
    Dysphagia 24:66-70. 2009
    ..Internal consistency allows the use of nine subscales of SWAL-QoL-NL for comparisons on a group level (0.80 < alpha < 0.92) only. Also a Symptom score can be derived from the raw data...

Research Grants52

  1. Manual Control of the Upper Esophageal Sphincter
    Peter Belafsky; Fiscal Year: 2013
    ..We propose to study a novel medical device, the swallow expansion device, to treat this devastating disorder in a sheep model of oropharyngeal dysphagia, which if successful, will establish the basis for human clinical trials. ..
  2. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2012
    ..The data are critical for a better understanding of the pathophysiological mechanisms of dysphagia in PD and for the development of novel therapies to treat this life-threatening disorder. ..
  3. CHEMOSENSORY TRANSDUCTION IN TASTE CELLS
    Stephen D Roper; Fiscal Year: 2012
    ..Secondarily, understanding acid taste transduction may shed light on pain mechanisms associated with inflammation and tissue acidosis. ..
  4. VOLITIONAL, BOLUS, AND AGE EFFECTS ON HUMAN SWALLOWING
    Peter Kahrilas; Fiscal Year: 2000
    ..The analysis tool of the 3-dimensional graphics program can quantify instantaneous intrapharyngeal volume, which coupled with pressure data from the pharyngeal outlet, may yield a useful parameter of swallow efficacy. ..
  5. Lingual Mechanical Function During Swallowing
    Richard Gilbert; Fiscal Year: 2005
    ..It is anticipated that this understanding will result in novel hypotheses of pathological lingual function for patients with oropharyngeal dysphagia. ..
  6. Realtime Internet Evaluation of Oropharyngeal Swallowing
    ADRIENNE PERLMAN; Fiscal Year: 2007
    ..Confirmation of the reliability of the telefluoroscopic evaluation can result in equity of access for underserved groups for whom SLPs with expertise in dysphagia diagnosis are locally unavailable. [unreadable] [unreadable] [unreadable]..
  7. A randomized trial of NMES vs. traditional dysphagia therapy after stroke
    Giselle Mann; Fiscal Year: 2009
    ..These results will be invaluable in developing effective management strategies and directing appropriate health care resources for the treatment of dysphagia following stroke. ..
  8. Effects of Swallowing Therapy in Head and Neck Cancer
    Jerilyn Logemann; Fiscal Year: 2006
    ....
  9. Oropharyngeal Function After Radiotherapy with IMRT
    Jerilyn A Logemann; Fiscal Year: 2010
    ..This project attempts to quantify the swallow problems associated with this specific treatment and the effects of interventions for these swallow problems. ..
  10. Effects of LSVT on Dysphagia in Parkinson's Disease
    Jerilyn Logemann; Fiscal Year: 2003
    ..This application proposes to generate pilot data on the effects of LSVT on aspiration, a potentially dangerous and costly side effect of dysphagia in Parkinson's disease. ..
  11. Coordination of Respiration with Deglutition & Phonation in Ataxia-Telangiectasia
    Maureen Lefton Greif; Fiscal Year: 2007
    ..Furthermore, developing A- T as a model will form the basis for applying this non-invasive technology to other children with dysphagia. [unreadable] [unreadable] [unreadable]..
  12. Reinnervation of Paralyzed Muscle by Nerve-Muscle-Endplate Band Grafting
    Liancai Mu; Fiscal Year: 2011
    ..Our preliminary work showed that this technique results in better outcomes than currently used methods. The data obtained from this research is useful for future clinical application to treat muscle paralysis. ..
  13. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  14. Measurement model for respiratory-swallowing impairment
    Bonnie Martin Harris; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  15. Stadardized Assesment of Swallowing Impairment
    Bonnie Martin Harris; Fiscal Year: 2007
    ..abstract_text> ..
  16. RESPIRATORY AND LARYNGEAL DYNAMICS DURING SWALLOW
    Bonnie Martin Harris; Fiscal Year: 2002
    ..Cluster analysis will be applied to identify critical clusters of respiratory-swallowing dynamics. Mixed- effects analysis of variance will estimate the key study parameters of age group specific durations and variability. ..
  17. Hospice Pain Control: Developing an Opioid Order Sheet
    Barbara Murphy; Fiscal Year: 2006
    ..Once the modifications lave been made, we will conduct a pilot study to assess feasibility, utility and efficacy of the order sheet in the outpatient hospice setting. [unreadable] [unreadable]..
  18. Peripheral Nerve Implementation of Functional Neuroprostheses
    DUSTIN TYLER; Fiscal Year: 2008
    ..We expect this work will make a significant impact in upper extremity FES applications and pave the path to other applications, such as neural interfaces for amputee prosthetics. [unreadable] [unreadable] [unreadable]..
  19. Regulation of CD80 Molecule in Oral Cancer
    GIOVANA THOMAS; Fiscal Year: 2008
    ..Such action may, potentially, increase anti-tumor immune responses and, therefore, survival of patients with this disease. ..
  20. Biochemical markers of bone turnover in metastatic prostate cancer
    Primo N Lara; Fiscal Year: 2010
    ....
  21. Lesch-Nyhan disease: dissecting the functions of HGprt
    HYDER JINNAH; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Measuring Quality - The Impact of Patient Complexity
    Robert Centor; Fiscal Year: 2007
    ..Finally, we hope to present an economical research agenda to the research community and AHRQ at the national meeting. [unreadable] [unreadable] [unreadable]..
  23. PLACEBO CONTROLLED STUDY OF BACLOFEN FOR GERD IN CHILDREN WITH CEREBRAL PALSY
    Samuel Nurko; Fiscal Year: 2008
    ..This study will serve as a basis to test the medication in otherwise healthy children with GERD. [unreadable] [unreadable] [unreadable]..
  24. Early Treatment of ALS with Nutrition and NIPPV
    Edward Kasarskis; Fiscal Year: 2007
    ..In addition, our results will be immediately applicable for use by clinicians in practice and will provide the basis to re-formulate the experimental design of future drug trials in ALS. ..
  25. Neuropeptide Y for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2003
    ..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..
  26. PRO-Surveyor: Device for Capturing Patient Reported Outcome Data in Children
    Nadine Connor; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  27. Research Symposium on Functional Abdoninal Pain in Children
    Samuel Nurko; Fiscal Year: 2007
    ..7. To educate the NASPGHAN membership on the state of the art of functional abdominal pain and IBS in children. [unreadable] [unreadable] [unreadable]..
  28. NEUROMUSCULAR STRATEGIES FOR HUMAN TONGUE MOVEMENT
    ALAN SOKOLOFF; Fiscal Year: 2007
    ..These studies will provide important information on the neurobiology of the tongue motor system and will provide the first direct tests of the molecular and physiological bases of aging of the human tongue motor system. ..
  29. Long-term White Matter Changes Resulting from Delirium after Surgery
    James Rudolph; Fiscal Year: 2008
    ..If the hypotheses are confirmed, this will alter our fundamental understanding of delirium as a short-term disorder and future studies can use imaging to prevent, identify, and treat delirium. [unreadable] [unreadable] [unreadable]..
  30. Oropharyngeal Bolus Flow Dynamics
    Mark Nicosia; Fiscal Year: 2008
    ..This will lead naturally to an optimization tool, which could be added to the current arsenal of tools with which to analyze available diagnostic and therapeutic procedures and to develop new ones. [unreadable] [unreadable] [unreadable]..
  31. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  32. Treatment of Dysphagia Using the Mendelsohn Maneuver
    GARY MCCULLOUGH; Fiscal Year: 2004
    ..Specific Aim 3: To determine the effect of the Mendelsohn Maneuver on an overall dysphagia severity scale (Dysphagia Oral Severity Scale - DOSS). Specific Aim 4: To determine the most appropriate dose of treatment. ..
  33. Comparison of Two Therapies for UES Dysphagia
    Reza Shaker; Fiscal Year: 2004
    ..anteroposterior and lateral diameter of maximum deglutitive UES opening, and b. maximum deglutitive laryngeal anterior and superior excursions. ..
  34. Creatine: Is It a Body Builder for Cancer Patients?
    Aminah Jatoi; Fiscal Year: 2004
    ..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
  35. Mechanisms and Therapeutics in Cancer Anorexia/Cachexia
    Aminah Jatoi; Fiscal Year: 2004
    ..This K23 grant application will serve as a springboard to allow her to delve into the pathophysiology of this syndrome and to develop into an independent clinical investigator. ..
  36. DEVELOPMENT OF A STOKE OUTCOME PREDICTION MODEL
    Judith Hinchey; Fiscal Year: 2004
    ..Supervision for this project will be by a multi disciplinary team at the University of Rochester, University of California and the Cleveland Clinic Foundation with experience in fostering the development of clinical researches. ..
  37. The Epidemiology of Barrett's Esophagus in Children
    Mark Gilger; Fiscal Year: 2005
    ....
  38. Reflux Disease in Patients with Throat Signs/Symptoms
    Michael Vaezi; Fiscal Year: 2005
    ..These methods will be employed pre- and post-therapy on all patients to assess their potential clinical utility, especially in those unresponsive to medical therapy after aggressive acid suppression. ..
  39. Regulation of the Cough Reflex
    Donald Bolser; Fiscal Year: 2006
    ..Furthermore, this project will test the proposed roles of medullary and spinal cellular elements that contribute to the generation and control of expiratory motor discharge during cough. ..
  40. Physiology of Swallowing and Airway Protection
    David Paydarfar; Fiscal Year: 2006
    ..We will stimulate the ISLN (using optimum parameters from Aim 3) in patients with neurogenic dysphagia caused by focal cerebral damage, and we will test for improvement in swallowing and decrease in aspiration. ..
  41. NY Stroke Rehabilitation Clinical Trials Network
    Michael Reding; Fiscal Year: 2003
    ....
  42. DYSRHYTHMIAS OF THE RESPIRATORY OSCILLATOR
    David Paydarfar; Fiscal Year: 2002
    ....
  43. CLINICAL TRIALS FOR PEDIATRIC SPINAL MUSCULAR ATROPHY
    Susan Iannaccone; Fiscal Year: 2005
    ..This continuing project is an important step toward our ultimate goal of finding an effective treatment for SMA. ..
  44. Oral Care and Respiratory Pathogen Colonization
    Ozan Akca; Fiscal Year: 2004
    ..Reducing respiratory pathogen colonization in the mouth could significantly reduce the morbidity and cost of VAP. ..
  45. DIVERGENT CAUSAL PATHWAYS TO MELANOMA: A COMBINED ANALYSIS OF 12 CASE-CONTROL STU
    David Whiteman; Fiscal Year: 2008
    ..Ultimately, the results of this research may contribute to better preventive strategies to reduce the number of people who die from melanoma (currently 8000 people each year in the United States). [unreadable] [unreadable] [unreadable]..
  46. Molecular epidemiology of Barretts esophagus and cancer
    David Whiteman; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  47. Pimecrolius on T cell Responses in Atopic March
    Jonathan Spergel; Fiscal Year: 2008
    ..In third aim of the trial, we explore the effects of pimecrolimus as a disease-modifying agent in the prevention of asthma. Asthma phenotype will be examined by spirometry per and post-beta-2-agonist and exhaled nitric oxide. ..
  48. A randomized trial of influenza vaccination of Hutterite children
    Mark Loeb; Fiscal Year: 2006
    ..We believe that the trial we propose will lead to important data that can inform policy on influenza immunization strategy. [unreadable] [unreadable] [unreadable]..