periodontitis

Summary

Summary: Inflammatory reaction of the tissues surrounding a tooth (periodontium), usually resulting from the extension of gingival inflammation (gingivitis) into the periodontium. (From Dorland, 27th ed)

Top Publications

  1. ncbi Periodontitis: a polymicrobial disruption of host homeostasis
    Richard P Darveau
    University of Washington, Seattle, Washington 98195, USA
    Nat Rev Microbiol 8:481-90. 2010
  2. ncbi Prevalence of periodontitis in adults in the United States: 2009 and 2010
    P I Eke
    Division of Population Health, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention CDC, Atlanta, GA 30341, USA
    J Dent Res 91:914-20. 2012
  3. ncbi Treatment of periodontitis and endothelial function
    Maurizio S Tonetti
    Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, USA
    N Engl J Med 356:911-20. 2007
  4. pmc Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray
    Ana Paula V Colombo
    Department of Medical Microbiology, Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    J Periodontol 80:1421-32. 2009
  5. pmc Bacterial community shift in treated periodontitis patients revealed by ion torrent 16S rRNA gene amplicon sequencing
    Sebastian Jünemann
    Department for Periodontology, University of Munster, Munster, Germany
    PLoS ONE 7:e41606. 2012
  6. ncbi Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis
    Stanley C Holt
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:72-122. 2005
  7. ncbi Underestimation of periodontitis in NHANES surveys
    Jasim M Albandar
    Periodontal Diagnostics Research Laboratory, Department of Periodontology and Oral Implantology, Temple University School of Dentistry, Philadelphia, PA, USA
    J Periodontol 82:337-41. 2011
  8. ncbi Clinical review: Association between metabolic syndrome and periodontitis: a systematic review and meta-analysis
    Luigi Nibali
    Periodontology Unit and Department of Clinical Research, University College London Eastman Dental Institute, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    J Clin Endocrinol Metab 98:913-20. 2013
  9. ncbi Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients
    B G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Periodontol 71:1528-34. 2000
  10. ncbi MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis
    Yali Liu
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Stem Cells 29:1804-16. 2011

Detail Information

Publications320 found, 100 shown here

  1. ncbi Periodontitis: a polymicrobial disruption of host homeostasis
    Richard P Darveau
    University of Washington, Seattle, Washington 98195, USA
    Nat Rev Microbiol 8:481-90. 2010
    b>Periodontitis, or gum disease, affects millions of people each year...
  2. ncbi Prevalence of periodontitis in adults in the United States: 2009 and 2010
    P I Eke
    Division of Population Health, National Center for Chronic Disease and Health Promotion, Centers for Disease Control and Prevention CDC, Atlanta, GA 30341, USA
    J Dent Res 91:914-20. 2012
    This study estimated the prevalence, severity, and extent of periodontitis in the adult U.S. population, with data from the 2009 and 2010 National Health and Nutrition Examination Survey (NHANES) cycle...
  3. ncbi Treatment of periodontitis and endothelial function
    Maurizio S Tonetti
    Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, USA
    N Engl J Med 356:911-20. 2007
    Systemic inflammation may impair vascular function, and epidemiologic data suggest a possible link between periodontitis and cardiovascular disease.
  4. pmc Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray
    Ana Paula V Colombo
    Department of Medical Microbiology, Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    J Periodontol 80:1421-32. 2009
    This study compared the subgingival microbiota of subjects with refractory periodontitis (RP) to those in subjects with treatable periodontitis (GRs = good responders) or periodontal health (PH) using the Human Oral Microbe ..
  5. pmc Bacterial community shift in treated periodontitis patients revealed by ion torrent 16S rRNA gene amplicon sequencing
    Sebastian Jünemann
    Department for Periodontology, University of Munster, Munster, Germany
    PLoS ONE 7:e41606. 2012
    b>Periodontitis, one of the most common diseases in the world, is caused by a mixture of pathogenic bacteria and inflammatory host responses and often treated by antimicrobials as an adjunct to scaling and root planing (SRP)...
  6. ncbi Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the "red complex", a prototype polybacterial pathogenic consortium in periodontitis
    Stanley C Holt
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:72-122. 2005
  7. ncbi Underestimation of periodontitis in NHANES surveys
    Jasim M Albandar
    Periodontal Diagnostics Research Laboratory, Department of Periodontology and Oral Implantology, Temple University School of Dentistry, Philadelphia, PA, USA
    J Periodontol 82:337-41. 2011
    ..Studies show that surveys that use partial examination protocols underestimate the prevalence of periodontitis, and the amount of underestimation varies depending on the number and type of sites examined, the case-..
  8. ncbi Clinical review: Association between metabolic syndrome and periodontitis: a systematic review and meta-analysis
    Luigi Nibali
    Periodontology Unit and Department of Clinical Research, University College London Eastman Dental Institute, 256 Gray s Inn Road, London WC1X 8LD, United Kingdom
    J Clin Endocrinol Metab 98:913-20. 2013
    ..Several epidemiological studies have reported an association between metabolic syndrome (MetS) and periodontal diseases (PDs). The aim of this systematic review was to investigate the existence and magnitude of this association...
  9. ncbi Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients
    B G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, The Netherlands
    J Periodontol 71:1528-34. 2000
    b>Periodontitis is a common, often undiagnosed, chronic infection of the supporting tissues of the teeth, epidemiologically associated with cardiovascular diseases...
  10. ncbi MiR-17 modulates osteogenic differentiation through a coherent feed-forward loop in mesenchymal stem cells isolated from periodontal ligaments of patients with periodontitis
    Yali Liu
    Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, China
    Stem Cells 29:1804-16. 2011
    Chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis, are the most common causes of bone tissue destruction...
  11. ncbi Inflammation and bone loss in periodontal disease
    David L Cochran
    Department of Periodontics, The University of Texas Health Science Center at San Antonio, 7702 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Periodontol 79:1569-76. 2008
    ..OPG mRNA expression and protein production do not generally seem to be increased in the periodontitis lesion...
  12. ncbi Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective
    G W Taylor
    Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
    Ann Periodontol 6:99-112. 2001
    ..Additional evidence to support the effect of severe periodontitis on increased risk for poorer glycemic control comes from 2 follow-up observational studies...
  13. ncbi Periodontal microbial ecology
    Sigmund S Socransky
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:135-87. 2005
  14. ncbi The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis
    Nilo Guliberto Martins Chávarry
    Division of Graduate Periodontics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Oral Health Prev Dent 7:107-27. 2009
    ..The aim of this study was to systematically review the studies on the association between diabetes mellitus (DM) and destructive periodontal disease...
  15. ncbi Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    Natalia Wegner
    The Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Immunol Rev 233:34-54. 2010
    ..b>Periodontitis, in which Porphyromonas gingivalis is a major pathogenic bacterium, has been linked to RA in epidemiological ..
  16. pmc Periodontitis and diabetes: a two-way relationship
    P M Preshaw
    School of Dental Sciences and Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK
    Diabetologia 55:21-31. 2012
    b>Periodontitis is a common chronic inflammatory disease characterised by destruction of the supporting structures of the teeth (the periodontal ligament and alveolar bone)...
  17. ncbi Relationship between periodontal infections and systemic disease
    G J Seymour
    Faculty of Dentistry, University of Otago, Dunedin, New Zealand
    Clin Microbiol Infect 13:3-10. 2007
    Oral conditions such as gingivitis and chronic periodontitis are found worldwide and are among the most prevalent microbial diseases of mankind...
  18. pmc Systemic diseases caused by oral infection
    X Li
    Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    Clin Microbiol Rev 13:547-58. 2000
    Recently, it has been recognized that oral infection, especially periodontitis, may affect the course and pathogenesis of a number of systemic diseases, such as cardiovascular disease, bacterial pneumonia, diabetes mellitus, and low ..
  19. ncbi Case definitions for use in population-based surveillance of periodontitis
    Roy C Page
    Regional Clinical Dental Research Center, Schools of Dentistry and Medicine, University of Washington, Seattle, WA 98195, USA
    J Periodontol 78:1387-99. 2007
    Many definitions of periodontitis have been used in the literature for population-based studies, but there is no accepted standard...
  20. ncbi Association between overweight/obesity and periodontitis in adults. A systematic review
    Jean Suvan
    Unit of Periodontology, University College London UCL, Eastman Dental Institute, London, UK
    Obes Rev 12:e381-404. 2011
    Overweight and obesity have been suggested to be associated with periodontitis as published in studies and narrative summaries...
  21. ncbi The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction
    D T Graves
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Periodontol 74:391-401. 2003
    ..The use of antagonists to IL-1 and TNF in experimental periodontitis have demonstrated a cause-and-effect relationship between the activity of these cytokines and the spread of an ..
  22. ncbi RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis
    H Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, Massachusetts, USA
    FASEB J 20:401-3. 2006
    b>Periodontitis is a well-appreciated example of leukocyte-mediated bone loss and inflammation that has pathogenic features similar to those observed in other inflammatory diseases such as arthritis...
  23. ncbi T cells support osteoclastogenesis in an in vitro model derived from human periodontitis patients
    G Brunetti
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    J Periodontol 76:1675-80. 2005
    b>Periodontitis is characterized by alveolar bone destruction; however, the mechanisms responsible for bone damage are poorly understood. It has been reported that T cells are implicated in the pathogenesis of periodontitis...
  24. ncbi Gingival crevicular fluid levels of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in patients with chronic and aggressive periodontitis
    Bulent Kurtis
    Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey
    J Periodontol 76:1849-55. 2005
    ..to investigate the presence of MCP-1 in gingival crevicular fluid (GCF) samples from patients with chronic periodontitis (CP) and aggressive periodontitis (AgP) and to examine the possible correlations between the GCF levels of MCP-..
  25. ncbi Update of the case definitions for population-based surveillance of periodontitis
    Paul I Eke
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Periodontol 83:1449-54. 2012
    This report adds a new definition for mild periodontitis that allows for better descriptions of the overall prevalence of periodontitis in populations...
  26. ncbi Alteration of activity and survival of osteoblasts obtained from human periodontitis patients: role of TRAIL
    G Mori
    Department of Human Anatomy and Histology, University of Bari, Italy
    J Biol Regul Homeost Agents 21:105-14. 2007
    ..In conclusion, we show for the first time that the alveolar bone loss in Pd patients could be due to the increased TRAIL-mediated apoptosis of OBs...
  27. ncbi Oxidative damage of periodontal tissue in the rat periodontitis model: effects of a high-cholesterol diet
    Takaaki Tomofuji
    Department of Oral Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    FEBS Lett 580:3601-4. 2006
    Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model...
  28. ncbi Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints
    G P Garlet
    OSTEOimmunology Laboratory, Department of Biological Sciences, School of Dentistry of Bauru, Sao Paulo University, FOB USP, Al Octávio Pinheiro Brisola, 9 75 CEP 17012 901, Bauru, SP, Brazil
    J Dent Res 89:1349-63. 2010
    ....
  29. ncbi Maternal periodontitis as a potential risk variable for preeclampsia: a case-control study
    Fernanda Mafra Siqueira
    Department of Periodontology, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    J Periodontol 79:207-15. 2008
    Association studies between maternal periodontitis and an elevated risk for preeclampsia have shown conflicting results...
  30. ncbi Aspects of adaptive host response in periodontitis
    Tord Berglundh
    Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Clin Periodontol 32:87-107. 2005
    To review host response in periodontitis with respect to cellular composition of lesions, T cell receptor (TCR) gene expression, cytokine profiles of T-helper (Th) cells and autoimmune components.
  31. ncbi Gingival crevicular fluid alkaline phosphatase activity reflects periodontal healing/recurrent inflammation phases in chronic periodontitis patients
    Giuseppe Perinetti
    Department of Oral Sciences, University G D Annunzio, Chieti, Italy
    J Periodontol 79:1200-7. 2008
    ..Thus, the present study aimed to improve our understanding of how the healing of chronic periodontitis following scaling and root planing (SRP) affects GCF ALP activity after 15 and 60 days.
  32. ncbi The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis
    Amol Ashok Bahekar
    Department of Cardiology, Chicago Medical School North Chicago Veterans Affairs Medical Center, Chicago, IL 60064, USA
    Am Heart J 154:830-7. 2007
    Previous studies have shown conflicting results as to whether periodontitis (PD) is associated with increased risk of coronary heart disease (CHD). The aim of the current study was to evaluate whether such an association exists.
  33. ncbi Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994
    J M Albandar
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    J Periodontol 70:13-29. 1999
    ..This study estimated the prevalence and extent of periodontal disease in the United States using data from the third National Health and Nutrition Examination Survey (NHANES III)...
  34. ncbi Chronic periodontitis and the risk of tongue cancer
    Mine Tezal
    Department of Periodontics, State University of New York at Buffalo, NY, USA
    Arch Otolaryngol Head Neck Surg 133:450-4. 2007
    To assess the association between the history of chronic periodontitis and the risk of tongue cancer.
  35. ncbi Diabetes mellitus and periodontitis: a tale of two common interrelated diseases
    Evanthia Lalla
    Division of Periodontics, College of Dental Medicine, Columbia University, 630 West 168th Street, PH7E 110, New York, NY 10032, USA
    Nat Rev Endocrinol 7:738-48. 2011
    Diabetes mellitus (a group of metabolic disorders characterized by hyperglycemia) and periodontitis (a microbially induced inflammatory disorder that affects the supporting structures of teeth) are both common, chronic conditions...
  36. ncbi Periodontitis in RA-the citrullinated enolase connection
    Karin Lundberg
    The Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London W6 8LH, UK
    Nat Rev Rheumatol 6:727-30. 2010
    ..Two of the risk factors for RA-HLA-DRB1 shared epitope alleles and smoking-are also associated with periodontitis, which is largely, but not exclusively, caused by Porphyromonas gingivalis infection...
  37. pmc Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease
    Thomas Dietrich
    Department of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine, Boston, Mass, USA
    Circulation 117:1668-74. 2008
    Several epidemiological studies have suggested periodontitis as a risk factor for coronary heart disease (CHD), but results have been inconsistent.
  38. pmc Distribution and molecular characterization of Porphyromonas gingivalis carrying a new type of fimA gene
    I Nakagawa
    Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita Osaka 565 0871, Japan
    J Clin Microbiol 38:1909-14. 2000
    ..We previously examined the distribution of P. gingivalis in terms of fimA genotypes in periodontitis patients using a fimA type-specific PCR assay. However, some patients harbored P...
  39. ncbi Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation
    Lone Forner
    Department of Periodontology, University of Copenhagen, Copenhagen, Denmark
    J Clin Periodontol 33:401-7. 2006
    ..PRINCIPLE FINDINGS: The incidence and magnitude of bacteremia after scaling was significantly higher in periodontitis than in gingivitis patients and healthy control individuals...
  40. ncbi Systemic markers of inflammation in periodontitis
    Bruno G Loos
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Periodontol 76:2106-15. 2005
    ..literature review summarizes current knowledge on the systemic levels of selected markers of inflammation in periodontitis. From samples of peripheral blood the following cellular factors are discussed: total number of white blood ..
  41. ncbi New bacterial species associated with chronic periodontitis
    P S Kumar
    Department of Periodontology, School of Public Health, College of Medicine and Public Health, The Ohio State University, Columbus 43218, USA
    J Dent Res 82:338-44. 2003
    ..Associations with chronic periodontitis were observed for several new species or phylotypes, including uncultivated clones D084 and BH017 from the ..
  42. pmc Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase
    W T McGraw
    Department of Biochemistry, University of Georgia, Athens, Georgia 30602, USA
    Infect Immun 67:3248-56. 1999
    The initiation and progression of adult-onset periodontitis has been associated with infection of the gingival sulcus by Porphyromonas gingivalis...
  43. ncbi Physical activity, inflammatory biomarkers in gingival crevicular fluid and periodontitis
    Anne E Sanders
    Australian Research Centre for Population Oral Health, School of Dentistry, The University of Adelaide, Adelaide, Australia
    J Clin Periodontol 36:388-95. 2009
    ..examine the associations of physical activity with interleukin 1-beta (IL-1beta), C-reactive protein (CRP) and periodontitis and to investigate whether any relationship between physical activity and inflammatory mediators differs ..
  44. ncbi Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug
    Hsi Ming Lee
    Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Periodontol 75:453-63. 2004
    Administration of subantimicrobial dose doxycycline (SDD) to chronic periodontitis (CP) patients has repeatedly been found to reduce mammalian collagenase and other matrix metalloproteinase (MMP) activity in gingival tissues and ..
  45. ncbi Morphometric, histomorphometric, and microcomputed tomographic analysis of periodontal inflammatory lesions in a murine model
    Chung Hsing Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA, USA
    J Periodontol 78:1120-8. 2007
    Porphyromonas gingivalis is recognized as one of the major periodontal pathogens in chronic periodontitis, a common infectious disease characterized by inflammation and destruction of periodontal tissues. Several animal models with P...
  46. ncbi Autopathogenic correlation of periodontitis and rheumatoid arthritis
    John G Routsias
    Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
    Rheumatology (Oxford) 50:1189-93. 2011
    Recently, a number of studies have pointed to a potential relationship between periodontitis (PO) and RA and vice versa...
  47. ncbi Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue
    Takehiko Kubota
    Division of Periodontology, Department of Oral Biological Science, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Periodontol 79:166-73. 2008
    ..The purpose of this study was to examine the effect of different expression levels of MMPs and their inhibitors, the tissue inhibitors of matrix metalloproteinases (TIMPs), in periodontitis.
  48. ncbi Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells
    Nora Silva
    Area de Microbiologia, Dentistry School, University of Chile, Santiago, Chile
    J Clin Periodontol 35:206-14. 2008
    b>Periodontitis is an infection with an episodic nature of tissue support destruction...
  49. ncbi Receptor activator NF kappaB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis
    Tania Crotti
    Department of Pathology, University of Adelaide, Adelaide, Australia
    J Periodontal Res 38:380-7. 2003
    ..activator of nuclear factor kappaB ligand (RANKL), and its natural inhibitor, osteoprotegerin (OPG), in periodontitis. We aimed to compare the levels of the RANKL and OPG in the granulomatous tissue adjacent to areas of alveolar ..
  50. ncbi A systematic review and meta-analyses on C-reactive protein in relation to periodontitis
    Spiros Paraskevas
    Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Clin Periodontol 35:277-90. 2008
    ..This systematic review explored the robustness of observations that CRP is elevated in periodontitis. Similarly, the effect of periodontal therapy on CRP levels was investigated.
  51. ncbi The relationship between periodontitis and metabolic syndrome among a Korean nationally representative sample of adults
    Young Eun Kwon
    Department of Preventive and Public Health Dentistry, School of Dentistry, Seoul National University, Seoul, Korea
    J Clin Periodontol 38:781-6. 2011
    The aim of this study was to examine whether metabolic syndrome (MS) is associated with periodontitis in a representative sample of Korean adults, who were involved in the Fourth Korea National Health and Nutrition Examination Survey (..
  52. ncbi Periodontal pathogen carriage, rather than periodontitis, determines the serum antibody levels
    Pirkko J Pussinen
    Department of Oral and Maxillofacial Diseases, Institute of Dentistry, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    J Clin Periodontol 38:405-11. 2011
    We investigated in a nationally representative sample, how periodontitis modifies the association between the carriage of periodontal pathogens and serology.
  53. ncbi Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis
    Nurcan Buduneli
    Department of Periodontology, School of Dentistry, Ege University, Izmir, Turkey
    J Clin Periodontol 38:85-105. 2011
    ..A major challenge in clinical periodontics is to find a reliable molecular marker of periodontal tissue destruction with high sensitivity, specificity and utility...
  54. pmc n-3 fatty acids and periodontitis in US adults
    Asghar Z Naqvi
    Harvard Medical School, and a hospitalist, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Am Diet Assoc 110:1669-75. 2010
    b>Periodontitis is a common, chronic inflammatory disease. Although n-3 fatty acids have anti-inflammatory properties, it is unclear whether n-3 fatty acids can treat or prevent periodontitis.
  55. ncbi Periodontitis and diabetes associations with measures of atherosclerosis and CHD
    Janet H Southerland
    School of Dentistry, Meharry Medical College, Nashville, TN 37208, USA
    Atherosclerosis 222:196-201. 2012
    ....
  56. pmc fimA genotypes and multilocus sequence types of Porphyromonas gingivalis from patients with periodontitis
    Morten Enersen
    Institute of Oral Biology, Faculty of Dentistry, University of Oslo, P O Box 1052, NO 0316 Oslo, Norway
    J Clin Microbiol 46:31-42. 2008
    ..different nucleotide sequences, with fimA genotypes II and IV being prevalent in isolates from patients with periodontitis. The aims of this study were to examine the distribution of fimA genotypes in a collection of 82 P...
  57. ncbi Periodontitis and risk of diabetes mellitus
    Abhijit Gurav
    Department of Periodontics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India
    J Diabetes 3:21-8. 2011
    ..Diabetes is a pandemic in both developed and developing countries. In recent years, a link between periodontitis and diabetes mellitus has been postulated...
  58. ncbi Increased physical activity decreases periodontitis risk in men
    Anwar T Merchant
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Epidemiol 18:891-8. 2003
    Increased physical activity improves insulin sensitivity and glucose metabolism, and may therefore affect incidence of periodontitis.
  59. ncbi Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis
    Elliot D Rosenstein
    Arthritis and Rheumatic Disease Center, St Barnabas Medical Center, 200 South Orange Avenue, Livingston, NJ 07039, USA
    Prostaglandins Leukot Essent Fatty Acids 68:213-8. 2003
    ..eicosapentaenoic acid, and borage oil as a source of the n-6 PUFA, gamma-linolenic acid (GLA), to adults with periodontitis. Thirty adult human subjects with periodontitis were administered either fish oil 3000 mg daily; borage oil ..
  60. ncbi Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases
    T E Van Dyke
    Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
    J Dent Res 82:82-90. 2003
    ..and molecular mediators that are responsible for regulation of the inflammatory response in diseases such as periodontitis, with a focus on lipid mediators of inflammation...
  61. pmc Oxidative stress, systemic inflammation, and severe periodontitis
    F D'Aiuto
    Periodontology Unit, Division of Clinical Research, UCL Eastman Dental Institute and Hospital, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Dent Res 89:1241-6. 2010
    Periodontal infections have been associated with a state of chronic inflammation. To ascertain whether severe periodontitis and its treatment are associated with oxidative stress, we recruited 145 cases (periodontitis) and 56 controls in ..
  62. ncbi Periodontitis as a potential risk factor for peri-implantitis
    Stefan Renvert
    Department of Health Sciences, Kristianstad University, Kristianstad, Sweden
    J Clin Periodontol 36:9-14. 2009
    To review the literature regarding the possible association between a previous history of periodontitis and peri-implantitis.
  63. ncbi Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis
    M Mogi
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
    J Dent Res 83:166-9. 2004
    ..increased concentration of RANKL and a decreased concentration of OPG were detected in GCF from patients with periodontitis (*p < 0.05 vs. control subjects)...
  64. pmc Effect of periodontal treatment on glycemic control of diabetic patients: a systematic review and meta-analysis
    Wijnand J Teeuw
    Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam, The Netherlands
    Diabetes Care 33:421-7. 2010
    There is growing evidence that periodontitis may affect general health. This study was assigned to explore the robustness of observations that periodontal therapy leads to the improvement of glycemic control in diabetic patients.
  65. ncbi Toll-like receptors and their role in periodontal health and disease
    Rangsini Mahanonda
    Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
    Periodontol 2000 43:41-55. 2007
  66. ncbi Severe chronic obstructive pulmonary disease: association with marginal bone loss in periodontitis
    I Leuckfeld
    Institute of Oral Biology, University of Oslo, Oslo, Norway
    Respir Med 102:488-94. 2008
    An association between chronic marginal periodontitis and chronic obstructive pulmonary disease (COPD) has been suggested...
  67. ncbi Position paper: epidemiology of periodontal diseases
    Brian Burt
    J Periodontol 76:1406-19. 2005
  68. ncbi Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis
    A J Delima
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, MA, USA
    J Clin Periodontol 28:233-40. 2001
    ..and TNF in the loss of connective tissue attachment in a Macaca fascicularis primate model of experimental periodontitis. Silk ligatures impregnated with the periodontal pathogen, Porphyromonas gingivalis were wrapped around the ..
  69. pmc Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine
    Yi Liu
    Salivary Gland Disease Center and the Molecular Laboratory for Gene Therapy, Capital Medical University School of Stomatology, Beijing 100050, China
    Stem Cells 26:1065-73. 2008
    b>Periodontitis is a periodontal tissue infectious disease and the most common cause for tooth loss in adults. It has been linked to many systemic disorders, such as coronary artery disease, stroke, and diabetes...
  70. ncbi Periodontitis and diabetes interrelationships: role of inflammation
    A M Iacopino
    Division of Prosthodontics, Marquette University School of Dentistry, Milwaukee, Wisconsin, USA
    Ann Periodontol 6:125-37. 2001
    ..One of these complications is periodontal disease (periodontitis). Periodontitis is much more than a localized oral infection...
  71. ncbi Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo
    Hatice Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, MA 02118, USA
    J Immunol 179:7021-9. 2007
    ..In this study, we report the treatment of established periodontitis using RvE1 as a monotherapy in rabbits compared with structurally related lipids PGE(2) and leukotriene B(4)...
  72. ncbi Bacteraemia following periodontal procedures
    Denis F Kinane
    University of Louisville School of Dentistry, Louisville, KY 40292, USA
    J Clin Periodontol 32:708-13. 2005
    ..These systemic conditions could be initiated or detrimentally influenced by the repeated entry of bacteria into the bloodstream...
  73. pmc B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease
    Toshihisa Kawai
    Department of Immunology, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA
    Am J Pathol 169:987-98. 2006
    ..These results suggest that activated T and B cells can be the cellular source of RANKL for bone resorption in periodontal diseased gingival tissue...
  74. ncbi Mapping the pathogenesis of periodontitis: a new look
    Kenneth S Kornman
    Interleukin Genetics, 135 Beaver Street, Waltham, MA 02452, USA
    J Periodontol 79:1560-8. 2008
    Chronic adult periodontitis is a bacterially induced chronic inflammatory disease that destroys the connective tissue and bone that support teeth...
  75. ncbi Metabolic syndrome and periodontitis: is oxidative stress a common link?
    P Bullon
    Deptartment of Periodontology, Dental School, University of Sevilla, Spain
    J Dent Res 88:503-18. 2009
    A review of pathological mechanisms that can explain the relationship between periodontitis and cardiovascular disease (CVD) is necessary to improve the management of both conditions...
  76. pmc The dual role of p55 tumour necrosis factor-alpha receptor in Actinobacillus actinomycetemcomitans-induced experimental periodontitis: host protection and tissue destruction
    G P Garlet
    Department of Biological Sciences, School of Dentistry of Bauru, Bauru, Brazil
    Clin Exp Immunol 147:128-38. 2007
    ..Our results showed that TNF-alpha receptor p55-deficient mice [p55TNF-knock-out (KO)] developed a less severe periodontitis in response to A...
  77. ncbi Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population
    Carlene Tsai
    Harvard School of Dental Medicine, Boston, MA, USA
    Community Dent Oral Epidemiol 30:182-92. 2002
    ..We investigated the association between glycemic control of type 2 diabetes mellitus (type 2 DM) and severe periodontal disease in the US adult population ages 45 years and older...
  78. ncbi Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks
    Giovanni E Salvi
    Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland
    J Clin Periodontol 35:398-409. 2008
    ..To review the evidence for the association between diabetes and periodontal and peri-implant conditions and the impact of periodontal therapy in subjects with diabetes...
  79. ncbi Periodontal diseases and cardiovascular events: meta-analysis of observational studies
    Alessandra Blaizot
    Faculte de Chirurgie Dentaire, 3 chemin des Maraichers, Toulouse 04, France
    Int Dent J 59:197-209. 2009
    ..Meta-analyses were conducted to examine the association between exposure to periodontitis and cardiovascular diseases.
  80. pmc Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis
    Natalia Wegner
    Imperial College London, London, UK
    Arthritis Rheum 62:2662-72. 2010
    ..To investigate protein citrullination by the periodontal pathogen Porphyromonas gingivalis as a potential mechanism for breaking tolerance to citrullinated proteins in rheumatoid arthritis (RA)...
  81. ncbi Gram-negative periodontal bacteria induce the activation of Toll-like receptors 2 and 4, and cytokine production in human periodontal ligament cells
    Ying Sun
    Department of Periodontology, Ninth People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    J Periodontol 81:1488-96. 2010
    b>Periodontitis is a bacterially induced chronic inflammatory disease. Toll-like receptors (TLRs), which could recognize microbial pathogens, are important components in the innate and adaptive immune systems...
  82. ncbi Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease
    James D Beck
    Department of Dental Ecology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Periodontol 76:2089-100. 2005
    ..Principal component analyses illustrate the complexity of the interactions among risk factors, exposures, and outcomes. These analyses provide an initial clustering that describes and suggests the presence of specific syndromes...
  83. ncbi Systemic anti-infective periodontal therapy. A systematic review
    Anne D Haffajee
    Department of Periodontology, Forsyth Institute, Boston, Massachusetts, USA
    Ann Periodontol 8:115-81. 2003
    ..Periodontal diseases are infections and thus systemically administered antibiotics are often employed as adjuncts for their control. There are conflicting reports as to whether these agents provide a therapeutic benefit...
  84. ncbi Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice
    Evanthia Lalla
    Division of Periodontics, School of Dental and Oral Surgery, Columbia University, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 23:1405-11. 2003
    ....
  85. ncbi Local and systemic total antioxidant capacity in periodontitis and health
    G R Brock
    Periodontal Research Group, School of Dentistry, University of Birmingham, Birmingham, UK
    J Clin Periodontol 31:515-21. 2004
    ..The aim of this cross-sectional study was to determine both local (saliva and gingival crevicular fluid (GCF) and peripheral (plasma and serum) antioxidant capacity in periodontal health and disease...
  86. ncbi Clinical and microbiological effects of topical subgingival application of hyaluronic acid gel adjunctive to scaling and root planing in the treatment of chronic periodontitis
    Yi Xu
    Department of Operative Dentistry and Periodontology, Dental School, Hua Xi Medical Center, Sichuan University, Chengdu, China
    J Periodontol 75:1114-8. 2004
    ..Hyaluronic acid (HA) has shown anti-inflammatory effects in gingivitis therapy. The potential benefits of local subgingival application of HA adjunctive to scaling and root planing (SRP) were evaluated in this study...
  87. ncbi Comparative proteomic analysis of whole saliva from chronic periodontitis patients
    Lorena Da Rós Gonçalves
    Laboratório de Genética Aplicada, Instituto Nacional de Cancer, INCA, Rio de Janeiro, Brazil
    J Proteomics 73:1334-41. 2010
    ..There is some evidence for changes in the protein composition of whole saliva from chronic periodontitis patients, but there have been no studies using a proteomic approach...
  88. ncbi Assessment of single nucleotide polymorphism at IL-1A+4845 and IL-1B+3954 as genetic susceptibility test for chronic periodontitis in Maharashtrian ethnicity
    Amit A Agrawal
    Department of Periodontics, Government Dental College and Hospital, Gandhi Medical College, Nagpur, Maharashtra, India
    J Periodontol 77:1515-21. 2006
    ....
  89. ncbi Identification of the osteoprotegerin/receptor activator of nuclear factor-kappa B ligand system in gingival crevicular fluid and tissue of patients with chronic periodontitis
    H K Lu
    College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    J Periodontal Res 41:354-60. 2006
    ..study aimed to identify and quantify OPG/RANKL in the gingival crevicular fluid (GCF) and connective tissue of patients with periodontitis, and to clarify possible correlations with disease severity and interleukin-6 (IL-6) cytokines.
  90. ncbi The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes
    Y Iwamoto
    Department of Periodontology and Endodontology, Okayama University Dental School, Japan
    J Periodontol 72:774-8. 2001
    ..49 pg/ml and 0.8%, respectively. CONCLUSION: The results indicate that anti-infectious treatment is effective in improving metabolic control in diabetics, possibly through reduced serum TNF-alpha and improved insulin resistance...
  91. ncbi Bioabsorbable membrane and bioactive glass in the treatment of intrabony defects in patients with generalized aggressive periodontitis: results of a 5-year clinical and radiological study
    Reiner Mengel
    Department of Periodontology, Philipps University Marburg, Marburg, Germany
    J Periodontol 77:1781-7. 2006
    ..clinical and radiological prospective 5-year study was to compare the long-term effectiveness of a bioabsorbable membrane and a bioactive glass in the treatment of intrabony defects in patients with generalized aggressive periodontitis.
  92. ncbi Rheumatoid arthritis and periodontal disease
    Jean Marie Berthelot
    Service de Rhumatologie, Hotel Dieu, CHU de Nantes, Place Alexis Ricordeau, 44093 Nantes Cedex 01, France
    Joint Bone Spine 77:537-41. 2010
    ..B-cell responses, with plasma cells being the predominant cell type found within gingival tissue affected with periodontitis and B cells being twice as numerous as T cells; RANK overexpression; and an increase in the ratio of RANK-L ..
  93. ncbi Identification of a new variant of fimA gene of Porphyromonas gingivalis and its distribution in adults and disabled populations with periodontitis
    I Nakagawa
    Department of Oral Microbiology, Osaka University Graduate School of Dentistry, Suita Osaka, Japan
    J Periodontal Res 37:425-32. 2002
    ..gingivalis possessing type II and type IV fimA genes and adult periodontitis. In that study, some clinical specimens were found to be positive for both types I- and II- fimA specific ..
  94. ncbi The relationship between body mass index and periodontitis in the Copenhagen City Heart Study
    Johanne Kongstad
    Periodontology Section, Department of Odontology, University of Copenhagen, Copenhagen, Denmark
    J Periodontol 80:1246-53. 2009
    ..to involve immunoinflammatory alterations, and the condition has been related to increased susceptibility to periodontitis. The present study analyzed the association between overweight/obesity and periodontitis assessed as clinical ..
  95. ncbi Microbiologic and immunologic characteristics of periodontal disease in Hispanic americans with type 2 diabetes
    Jeffrey L Ebersole
    Center for Oral Health Research, University of Kentucky, Lexington, KY, USA
    J Periodontol 79:637-46. 2008
    The microbiology of periodontitis in type 1 diabetes has been reported, but less is known about type 2 diabetes...
  96. ncbi The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial)
    Una M El-Shinnawi
    Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
    J Int Acad Periodontol 5:5-10. 2003
    ..was to investigate the effect of alendronate sodium, systemically induced in the treatment of patients with periodontitis. Twenty-four adult periodontitis patients were included in the study (for six months) and were divided into ..
  97. pmc Oral fluid-based biomarkers of alveolar bone loss in periodontitis
    Janet S Kinney
    Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, Ann Arbor, Michigan 48106, USA
    Ann N Y Acad Sci 1098:230-51. 2007
    ..Timely detection and diagnosis of disease may significantly affect the clinical management of periodontal patients by offering earlier, less invasive, and more cost-effective treatment therapies...
  98. ncbi Periodontitis and risk for atherosclerosis: an update on intervention trials
    Maurizio S Tonetti
    European Research Group on Periodontology ERGOPERIO, Berne, Switzerland
    J Clin Periodontol 36:15-9. 2009
    b>Periodontitis has been associated with an increased risk of cardiovascular events. The nature of the association is unclear because both periodontitis and cardiovascular disease (CVD) share a host of risk factors...
  99. ncbi Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions
    A Ashimoto
    Department of Periodontology, School of Dentistry, University of Southern California, Los Angeles 90089 0641, USA
    Oral Microbiol Immunol 11:266-73. 1996
    ..Prevotella nigrescens and Treponema denticola in subgingival specimens of 50 advanced periodontitis, 50 adult gingivitis and 50 pediatric gingivitis subjects...
  100. ncbi Microbial etiology of periodontitis
    Tatsuji Nishihara
    Department of Oral Microbiology, Kyushu Dental College, Fukuoka, Japan
    Periodontol 2000 36:14-26. 2004
  101. ncbi Genetic risk factors for periodontitis in a Japanese population
    T Kobayashi
    General Dentistry and Clinical Education Unit, Niigata University Medical and Dental Hospital, 2 5274 Gakkocho dori, Chuo Ku, Niigata 951 8514, Japan
    J Dent Res 88:1137-41. 2009
    Genetic variants at multiple loci have been shown to be associated with susceptibility to periodontitis. To better assess the genetic risk factors for periodontitis, we performed a case-control study in 319 Japanese individuals with ..

Research Grants76

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..b>Periodontitis is initiated by bacterial infection of the gingival tissues through a subgingival microbial biofilm on the ..
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..Chronic periodontitis is an inflammatory disease of the supporting tissues of the teeth leading to resorption of alveolar bone and ..
  3. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..adults 55 years and older. Metsyn is a putative factor for modified host immune response and acceleration of periodontitis. Physical activity and weight loss ameliorate risk of certain Metsyn-related complications, but it is unknown ..
  4. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
    ..Gingivitis and periodontitis are initiated by chronic infection of the gingival crevice with bacteria such as Porphryomonas gingivalis...
  5. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..In addition, A. baumannii biofilms have been implicated in cystic fibrosis, periodontitis and urinary tract infections, due to the bacteria's ability to colonize indwelling medical devices...
  6. Effects of periodontitis on insulin target organs and glucose homeostasis
    Keiko Watanabe; Fiscal Year: 2013
    ..provided by applicant): Epidemiological and clinical studies have established an association between periodontitis and Type 2 Diabetes Mellitus (T2DM)/obesity...
  7. A Novel Murine Model of Chronic Inflammatory Periodontitus
    Helieh S Oz; Fiscal Year: 2010
    ..e. periodontitis)...
  8. Studies on the virulence of Fillifactor alocis
    Hansel M Fletcher; Fiscal Year: 2013
    ..have allowed the identification of as-yet-culturable and fastidious organisms in patients suffering from periodontitis. Collectively, these studies have demonstrated that changes in periodontal status are associated with shifts ..
  9. Click chemistry for novel antimicrobials against periodontal pathogens
    Valery V Fokin; Fiscal Year: 2010
    ..the American public, with over 50% of adults having gingivitis and 5-15% having a moderate or severe form of periodontitis. Advanced stages of the disease lead to bone resorption and diminished tooth attachment...
  10. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..of MS, T1DM, RA, contact dermatitis, delayed type hypersensitivity (DTH) and bone resorption associated with periodontitis. These blockers have excellent safety profiles in animal models...
  11. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..may arise in the dental pulp (pulpitis), connective tissues supporting the dentition (gingivitis and periodontitis), muscles involved in mastication (myositis), or temporomandibular joint (arthritis or temporomandibular ..
  12. Transcriptional Regulation by a Deacetylase, CobB, in a Periodontopathogen
    DAVID J KOLODRUBETZ; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontitis is a disease of the subgingival crevice that leads to soft tissue degeneration and tooth loss...
  13. Metabolic Syndrome and Periodontitis
    ELIZABETH A KAYE; Fiscal Year: 2013
    ..This proposed epidemiologic study is a timely and cost-effective means to better understand the relationship between periodontal disease and the metabolic syndrome. ..
  14. Delivery of Polyphenols in Gum for Treatment of Gingivitis
    Craig S Miller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontitis represents a polymicrobial disease, in which a complex microbial ecology that matures in biofilms in the subgingival sulcus triggers a chronic immune-inflammatory lesion that destroys ..
  15. Transforming Women's Health: Discovery, Development, and Delivery
    Ellen M Daley; Fiscal Year: 2012
    ..Moreover, several oral-systemic linkages associated with poor oral health (i.e. periodontitis;oral bone loss;dental caries) that solely or disproportionally affect women include various infectious (HIV/..
  16. Optimal Prevention and Control of Periodontal Disease: The Periodontal Pocket Irr
    Thomas E Van Dyke; Fiscal Year: 2011
    ..efficacy of supra- and sub-gingival irrigation with chemotherapeutic agents for the control of gingivitis and periodontitis. The subject of optimal delivery systems, particularly for oral home care, is also an important factor in any ..
  17. Saliva and Serum Inflammatory Biomarkers in Periodontitis: A Study in Older Women
    Jean Wactawski Wende; Fiscal Year: 2010
    ..Ultimately, this information can be used to inform our understanding of the role of inflammation as one mechanism by which periodontal and other chronic diseases occur and progress. ..
  18. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..Furthermore, periodontitis is associated with systemic disorders such as diabetes mellitus, preterm low birth weight, and cardiovascular ..
  19. Bc12 regulates osteoclast survival
    Junro Yamashita; Fiscal Year: 2010
    Bone degenerative diseases such as osteoporosis, periodontitis, and rheumatoid arthritis are major health care concerns for the elderly population that is rapidly increasing in the US...
  20. Epigenetic regulation of viral infection and replication by periodontal bacteria
    Fengchun Ye; Fiscal Year: 2013
    ..It s well established that HIV patients exhibit increased prevalence and severity of chronic periodontitis and endure more frequent infections by herpesviruses such as herpes simplex virus (HSV), Epstein Barr virus (..
  21. Effect of MIP-1 delta on Osteoclast Development and Pathological Bone Resorption
    Scott L Kominsky; Fiscal Year: 2010
    ..macrophage inflammatory protein (MIP)-3a, whose expression has been reported in both rheumatoid arthritis and periodontitis, has been shown to enhance the development of bone-destroying cells called osteoclasts (OCL)...
  22. Fibronectin-binding Protein of Treponema Denticola in Periodontal Disease
    Xiaoping Xu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Periodontitis is the second most common disease worldwide and is induced by microorganisms including Treponema denticola...
  23. Bacterial peptidylarginine deiminase, a link between gums and joint disease
    JAN S POTEMPA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of tissues that support the teeth...
  24. Regulatory Mechanisms Controlling Expression of P. gingivalis Surface Structures
    MARY ELLEN DAVEY; Fiscal Year: 2013
    b>Periodontitis is a biofilm-mediated disease that afflicts 35% of the adult population in the US, and persistent infections are associated with systemic disease, including cardiovascular disease and stroke...
  25. Telomere Attrition Rate and Periodontitis: a nested case control study in the ARI
    ANNE ELIZABETH SANDERS; Fiscal Year: 2013
    ..provided by applicant): The biological mechanisms underlying racial and socioeconomic disparities in periodontitis are inadequately conceptualized, rarely investigated and poorly understood...
  26. Combinatorial Imaging of the Oral Microbiome
    Floyd E Dewhirst; Fiscal Year: 2010
    ..the oral microbial community is involved in the development of many oral diseases including dental caries and periodontitis. This proposal is to develop innovative, "combinatorial imaging" technology to study the precise spatial ..
  27. Tannerella forsythia intercations with host cells and other bacteria
    Ashu Sharma; Fiscal Year: 2012
    ..Moreover, the immune response to the BspA protein in patients with periodontitis will be determined to address the importance of BspA in pathogenesis...
  28. Molecular interactions: oral bacteria & matrix proteins
    Keith Mintz; Fiscal Year: 2010
    ..This bacterium is strongly associated with localized aggressive periodontitis (LAP) and with cases of adult periodontitis...
  29. Periodontal Pathogens-induced Atherosclerosis in ApoE-/- and Integrin Beta6-/- mi
    IRINA MARIE VELSKO; Fiscal Year: 2013
    ..Atherosclerosis-prone ApoEnull mice and periodontitis-prone integrin [unreadable]6-/- mice will be chronically orally infected with Pg+Td+Tf+Fn for 24 weeks, and ..
  30. Amelioration of Immune Cell-Mediated Periodontal Disease
    Toshihisa Kawai; Fiscal Year: 2012
    ..b>Periodontitis, which is responsible for half of all tooth loss in adults, occurs in moderate form in 30% of American adults ..
  31. Periodontitis and pre-clinical diabetes
    CYNTHIA MADELINE PEREZ; Fiscal Year: 2013
    ..Given the high prevalence of periodontal disease and type 2 diabetes, this study is highly significant as periodontal disease could be a modifiable risk factor for type 2 diabetes. ..
  32. Peripheral blood dendritic cells and periodontitis
    CHRISTOPHER WILLIAM CUTLER; Fiscal Year: 2012
    ..Chronic periodontitis (CP), initiated by P...
  33. NON-INVASIVE HIGH-RESOLUTION DIAGNOSIS OF PERIODONTAL ATTACHMENT LEVELS USING REA
    SAM M MUKDADI; Fiscal Year: 2010
    ..More advanced periodontal disease called periodontitis has recently been linked to the increased risk of systemic diseases including cardiovascular, diabetes, ..
  34. Minor fimbriae of P. gingivalis and dendritic cells
    AMIR EMANUEL ZEITUNI; Fiscal Year: 2010
    ..is a black pigmented, anaerobic, gram negative bacterium that is associated with most cases of chronic periodontitis (1). P...
  35. Counteracting microbial immune evasion for the treatment of periodontitis
    MEGAN LAVONNE MCINTOSH; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Periodontitis is a destructive inflammatory disease instigated by a number of microbial pathogens which have evolved mechanisms to manipulate the innate immune response for their own benefit...
  36. Dissection of the ACPA response in African-Americans with Rheumatoid Arthritis
    S Louis Bridges; Fiscal Year: 2013
    ..To examine associations of periodontitis and exposure to P...
  37. P. gingivalis-specific T cells in mice prone and resistant to periodontitis
    Massimo Costalonga; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontitis is a chronic inflammatory disease that affects 30-40% of the U.S. population. It is the leading cause of periodontal tissue destruction and tooth loss...
  38. Regeneration of periodontal structures through the recruitment of regulatory lymp
    ANDREW JASON GLOWACKI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): It is becoming clear that periodontitis is not only characterized by pathogenic infection, but even more so by a loss of immunological homeostasis...
  39. Immunodominant Stress Proteins of Porphyromonas gingivalis
    Dennis E Lopatin; Fiscal Year: 2010
    ..The long-term goals of this work is to deliniate the mechanisms of chaperone involvement in periodontitis and periodontitis-related systemic disease and to develop strategies for medicinal treatment for those ..
  40. Neutrophil and Dendritic Cell Interactions
    Elizabeth Scisci; Fiscal Year: 2013
    ..and may progress to a necrotic state causing collateral damage to surrounding tissues, eventually exacerbating periodontitis. These effete PMNs are, in turn, cleared by antigen presenting cells such as macrophages and via largely ..
  41. A novel strategy in antimicrobial drug discovery against Porphyromonas gingivalis
    VICTORIA NANETTE STONE; Fiscal Year: 2013
    ..By specifically targeting one of the primary pathogens, one could reduce the destructive factors triggering periodontitis while maintaining a person's healthy flora...
  42. Assessment of outcomes and cost-effectiveness in early orthodontic treatment
    James J Chen; Fiscal Year: 2013
    ..Chair of Preventive and Restorative Sciences and conducts public-health-related research on diabetes and periodontitis, and three co-mentors with one consultant: Dr...
  43. Regulation of Oral Bacteria by Pattern Recognition Receptors
    Naohiro Inohara; Fiscal Year: 2012
    ..some of which have been implicated as etiological agents of common diseases such as dental caries and periodontitis. Epithelial cells lining the oral cavity and gingival tissue are known to be involved in immune responses ..
  44. Effects of saliva on herpes simplex virus infection of oralcells
    CLAUDE F KRUMMENACHER; Fiscal Year: 2013
    ..This agent will provide an accessible target for therapeutic interventions to prevent HSV spread in the oral cavity and limit its potential aggravating activity in periodontitis.
  45. How interactions of oral bacteria enhance resistance to innate immunity
    Matthew Ramsey; Fiscal Year: 2010
    ..Aggregatibacter actinomycetemcomitans (Aa) grows in the human oral cavity and is a causitive agent of periodontitis. In the oral cavity, Aa must grow in close proximity to oral microbial flora, the most numerous of which are ..
  46. Vitamin D induction of antibacterial activity in gingival cells
    Gill Diamond; Fiscal Year: 2009
    ..has demonstrated an association between polymorphisms of the vitamin D receptor (VDR) gene and early-onset periodontitis. Based upon these results, we hypothesize that physiological doses of Vitamin D can increase antimicrobial ..
  47. Role of Obesity in Infection
    Salomon Amar; Fiscal Year: 2012
    ..The possible causal relationship(s) between obesity and periodontitis, and the underlying biological mechanisms warrant a robust investigation...
  48. Identification of anti-inflammatory compounds from chocolate for the treatment of
    Andy McShea; Fiscal Year: 2012
    ..compounds in chocolate that could be used to treat tissue inflammation associated with gingivitis and periodontitis. Previous studies have demonstrated that water soluble extracts of cocoa bean husks and chocolate can contain ..
  49. Mechanisms of Complement Evasion by Treponema denticola
    DANIEL PATRICK MILLER; Fiscal Year: 2013
    ..Treponema denticola is an oral, bacterial species that is strongly associated with the development of periodontitis. The periodontal pocket, the site of infection between the tooth and the gums, is bathed in crevicular fluid ..
  50. Is Mitf the Missing Puzzle Linking NFATc1 to Osteoclastogenesis
    Yi Ling Lin; Fiscal Year: 2010
    ..in preventing metabolic bone loss associated with menopause, it is not effective in preventing bone loss in periodontitis [8]...
  51. Mechanobiological Mechanism for Inflammaory Bone Loss
    Francis Young In Lee; Fiscal Year: 2013
    ..do not always effectively prevent or treat osteoporosis and inflammatory bone loss in rheumatoid arthritis, periodontitis, and implant loosening. Therefore, there is a barrier t developing effective therapeutics to preserve bone...
  52. Biosynthesis and Function of Treponema denticola Lipooligosaccharide
    Hui Wu; Fiscal Year: 2013
    ..species from the "red complex" bacterial community that is strongly associated with onset and progression of periodontitis. Periodontal disease is prevalent in humans, and has been associated with a variety of systemic diseases ..
  53. Immunological response, Viral Factors and Helminth Infections in Disease Expressi
    Edgar M Carvalho; Fiscal Year: 2012
    ..Disease Expression in HTLV-1" awarded by the NIH, we documented that neurological and joint manifestations, periodontitis, sicca syndrome, urinary manifestations and erectile dysfunction were higher among HTLV-1 carriers than in ..
  54. Social Stress Modulates Neuropeptide Y in a Model fo Periodontal Inflammation
    BRENDA FAYE READER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontitis is an infectious disease caused by the formation of bacterial plaque on teeth. Porphyromonas gingivalis (P...
  55. Biomarkers of Periodontal Disease Progression
    Ricardo P Teles; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Despite advances in our knowledge of the causes and risk factors associated with periodontitis, there are no signs of a decline in periodontal disease prevalence...
  56. MOLECULAR BASIS OF TOOTH ERUPTION
    Shaomian Yao; Fiscal Year: 2012
    ..because the periodontal ligament (PDL) is derived from the DF, the molecular regulation of osteoclastogenesis by the DF may suggest a similar role for the PDL in regulating alveolar bone loss seen in periodontitis.
  57. SGK1 is a Central Regulator of P. gingivalis-Induced Inflammation
    Huizhi Wang; Fiscal Year: 2013
    ..gingivalis) is a Gram-negative anaerobic bacterium and a causative agent of periodontitis. Studies assessing the host inflammatory response to P...
  58. Probing oral pathogen interactions in picoliter-scale enclosures
    AIMEE KATHERINE WESSEL; Fiscal Year: 2013
    ..and opportunistic pathogen, and colonizes adjacent to both Aa, the etiologic agent of localized aggressive periodontitis, and S. mutans, the primary causative agent of dental caries in humans...
  59. Regulation of Osteoclastogenesis and Arthritic Bone Resorption by RBP-J
    Baohong Zhao; Fiscal Year: 2013
    ..diseases characterized by inflammatory osteolysis, including rheumatoid arthritis (RA), psoriatic arthritis, periodontitis an peri-prosthetic loosening...
  60. Pathophysiology of Biphosphonate-Induced ONJ in a Novel Animal Model
    J Ignacio Aguirre; Fiscal Year: 2010
    ..We plan to test our central hypothesis by utilizing rice rats (Oryzomys palustris) with established periodontitis and determine the effects of ZOL and ALN on: 1) the progression of the periodontal damage by performing an ex-..
  61. Mechanism of ITAM Signal Regulation in Osteoclasts
    Mary Beth Humphrey; Fiscal Year: 2012
    ..throughout life and imbalances in formation and resorption lead to human diseases including osteoporosis and periodontitis, a mission of the agency. We are studying the negative regulation of ITAM-adapter signals in osteoclasts...
  62. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2009
    ..an important member of a consortium of microorganisms that are etiologic in the initiation and progression of periodontitis. In diseased sites, the local periodontal environment has low levels of oxygen and often has high ..
  63. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    ..inflammatory diseases of the supporting tissues of the teeth, and one of the more aggressive forms of chronic periodontitis is characterized by the destruction of the tooth's supporting structures...
  64. IDENTIFY ANTIGENIC DETERMINANTS OF HUMAN PERIODONTITIS
    YEN TUNG TENG; Fiscal Year: 2001
    Human periodontal diseases (e.g., periodontitis) are heterogeneous and result from specific bacteria-host immune interactions...
  65. Subgingival Drug Delivery for Periodontitis Prevention and Treatment
    MARTYN DARBY; Fiscal Year: 2009
    In addition to the role oral infections play in promoting tooth loss, periodontitis has also been associated with increasing the risk of other medical conditions such as coronary artery disease, stroke and myocardial infarction...
  66. Dose-dependent anti-inflammatory effects of vitamin D in a human gingivitis model
    Raul Garcia; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The burden of chronic gingivitis and periodontitis in the US is disproportionately high among Non-Hispanic Blacks compared to Non-Hispanic Whites...
  67. Role of Zonula Occludens Toxin in the Pathogenesis of Treponema denticola
    Chunhao Li; Fiscal Year: 2009
    ..are a group of infections that affect the structures surrounding teeth, mainly including gingivitis and periodontitis. The most common form of periodontal diseases is gingivitis, which is highly prevalent and can affect up to 90%..
  68. Lysine decarboxylase in periodontitis patients
    Martin Levine; Fiscal Year: 2004
    In chronic (formerly adult) periodontitis, bacteria destroy the dento-gingival junction, especially its Dentally attached (DAT) cells, keratinocytes that are activated by persistent trauma from mastication and oral hygiene...
  69. Transcriptional Regulation of Matrix Metalloproteinase-3 (MMP-3)
    RUTH BORGHAEI; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): In periodontitis, as well as rheumatoid arthritis and several other chronic inflammatory conditions, levels of inflammatory cytokine IL-1 are high and correlate with disease severity, ..
  70. DIABETES AND PERIODONTITIS MICROBIOLOGY AND IMMUNOLOGY
    JEROME HABER; Fiscal Year: 1990
    ..has indicated that specific bacterial species are responsible for the initiation and progression of periodontitis. A recent large scale study of patients with insulin dependent diabetes mellitus (IDDM) has shown that the ..
  71. The Role of Stress Induced Hypoxia in Periodontitis
    PRAVEEN GAJENDRAREDDY; Fiscal Year: 2009
    ..Previous studies have also shown decreased oxygenation of the tissues during periodontitis, and hyperbaric oxygen therapy to be of benefit in its treatment...
  72. EFFECTS OF TREATMENT ON EARLY ONSET PERIODONTITIS
    Frank Roberts; Fiscal Year: 2003
    ..research component involves an investigation of treatment effects on early onset (rapidly progressive) periodontitis patients and understanding the host response mechanisms involved in tooth debridement in this patient group...
  73. ANTIGENIC STUDIES OF A. ACTINOMYCETEMCOMITANS
    Joseph Zambon; Fiscal Year: 1990
    ..Intra-orally, this organism has recently been implicated in the etiology of localized juvenile periodontitis and rapidly progressing adult periodontitis. We have reported three serotypes of oral A...
  74. DEVELOPMENT OF A VACCINE FOR HUMAN PERIODONTITIS
    ROY PAGE; Fiscal Year: 2001
    DESCRIPTION (adapted from the Investigator's abstract): Periodontitis is a major cause of tooth loss in adults in the US and worldwide. There is a compelling need for new approaches to prevention and control...
  75. Vascular Tissue Invasion by Porphyromonas gingivalis
    Ling Li; Fiscal Year: 2005
    ..g.), a Gram-negative anaerobe is known to play a critical role in the development of periodontitis. Several lines of evidence had also indicated its role in the development of cardiovascular disease (CVD)...
  76. Effects of Formyl Peptide Receptor variants on function
    John Mills; Fiscal Year: 2005
    ..Evaluations of patients with aggressive periodontitis have indicated that their neutrophils demonstrated poor chemotactic response toward the formyl peptide, ..