periodontal diseases

Summary

Top Publications

  1. ncbi Periodontal diseases and health: Consensus Report of the Sixth European Workshop on Periodontology
    Denis Kinane
    Center for Oral Health and Systematic Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202, USA
    J Clin Periodontol 35:333-7. 2008
  2. pmc Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis
    Linda L Humphrey
    Oregon Evidence Based Practice Center, Veterans Affairs Medical Center, Portland, OR, USA
    J Gen Intern Med 23:2079-86. 2008
  3. ncbi Periodontal diseases
    Bruce L Pihlstrom
    Center for Clinical Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 6401, USA
    Lancet 366:1809-20. 2005
  4. ncbi Development of a classification system for periodontal diseases and conditions
    G C Armitage
    School of Dentistry, University of California San Francisco 94143 0650, USA
    Ann Periodontol 4:1-6. 1999
  5. ncbi Periodontal diagnoses and classification of periodontal diseases
    Gary C Armitage
    Department of Stomatology, School of Dentistry, University of California, San Francisco, California, USA
    Periodontol 2000 34:9-21. 2004
  6. ncbi Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective
    G W Taylor
    Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
    Ann Periodontol 6:99-112. 2001
  7. ncbi The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis
    Nilo Guliberto Martins Chávarry
    Division of Graduate Periodontics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Oral Health Prev Dent 7:107-27. 2009
  8. ncbi Diabetes mellitus and periodontal diseases
    Brian L Mealey
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 77:1289-303. 2006
  9. pmc Interspecies interactions within oral microbial communities
    Howard K Kuramitsu
    Department of Oral Boiology, School of Dental Medicine, State University of New York, Buffalo, New York, USA
    Microbiol Mol Biol Rev 71:653-70. 2007
  10. ncbi Systematic review of the association between respiratory diseases and oral health
    Amir Azarpazhooh
    Department of Community Dentistry, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    J Periodontol 77:1465-82. 2006

Detail Information

Publications364 found, 100 shown here

  1. ncbi Periodontal diseases and health: Consensus Report of the Sixth European Workshop on Periodontology
    Denis Kinane
    Center for Oral Health and Systematic Diseases, School of Dentistry, University of Louisville, Louisville, KY 40202, USA
    J Clin Periodontol 35:333-7. 2008
    The remit of this group was to update the knowledge base on periodontal diseases and health.
  2. pmc Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis
    Linda L Humphrey
    Oregon Evidence Based Practice Center, Veterans Affairs Medical Center, Portland, OR, USA
    J Gen Intern Med 23:2079-86. 2008
    ..Periodontal disease is common among adults in the US and is a potential source of chronic inflammation. Recent data have suggested an important role for chronic inflammation in the development of coronary heart disease (CHD)...
  3. ncbi Periodontal diseases
    Bruce L Pihlstrom
    Center for Clinical Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 6401, USA
    Lancet 366:1809-20. 2005
    The periodontal diseases are highly prevalent and can affect up to 90% of the worldwide population...
  4. ncbi Development of a classification system for periodontal diseases and conditions
    G C Armitage
    School of Dentistry, University of California San Francisco 94143 0650, USA
    Ann Periodontol 4:1-6. 1999
    ..and clinicians in the field of periodontology and related areas agreed upon a classification system for periodontal diseases was in 1989 at the World Workshop in Clinical Periodontics...
  5. ncbi Periodontal diagnoses and classification of periodontal diseases
    Gary C Armitage
    Department of Stomatology, School of Dentistry, University of California, San Francisco, California, USA
    Periodontol 2000 34:9-21. 2004
  6. ncbi Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective
    G W Taylor
    Department of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
    Ann Periodontol 6:99-112. 2001
    This review evaluates evidence for a bidirectional relationship between diabetes and periodontal diseases. A comprehensive Medline search of the post-1960 English language literature was employed to identify primary research reports of ..
  7. ncbi The relationship between diabetes mellitus and destructive periodontal disease: a meta-analysis
    Nilo Guliberto Martins Chávarry
    Division of Graduate Periodontics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Oral Health Prev Dent 7:107-27. 2009
    ..The aim of this study was to systematically review the studies on the association between diabetes mellitus (DM) and destructive periodontal disease...
  8. ncbi Diabetes mellitus and periodontal diseases
    Brian L Mealey
    Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Periodontol 77:1289-303. 2006
    ..is to provide the reader with practical knowledge concerning the relationship between diabetes mellitus and periodontal diseases. Over 200 articles have been published in the English literature over the past 50 years examining the ..
  9. pmc Interspecies interactions within oral microbial communities
    Howard K Kuramitsu
    Department of Oral Boiology, School of Dental Medicine, State University of New York, Buffalo, New York, USA
    Microbiol Mol Biol Rev 71:653-70. 2007
    ..This review describes some of these interesting interspecies-interaction scenarios...
  10. ncbi Systematic review of the association between respiratory diseases and oral health
    Amir Azarpazhooh
    Department of Community Dentistry, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    J Periodontol 77:1465-82. 2006
    ..The purpose of this review was to investigate evidence for a possible etiological association between oral health and pneumonia or other respiratory diseases...
  11. ncbi Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994
    J M Albandar
    National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    J Periodontol 70:13-29. 1999
    Accurate information on the prevalence and extent of periodontal diseases in the United States adult population is lacking...
  12. pmc Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST)
    Moise Desvarieux
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn, USA
    Circulation 111:576-82. 2005
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and subclinical atherosclerosis...
  13. ncbi Periodontal disease: associations with diabetes, glycemic control and complications
    G W Taylor
    School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
    Oral Dis 14:191-203. 2008
    ..This report reviews the evidence for adverse effects of diabetes on periodontal health and periodontal disease on glycemic control and complications of diabetes...
  14. ncbi Cytokines that promote periodontal tissue destruction
    Dana Graves
    Division of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, 100 E Newton Street, Boston, MA 02118, USA
    J Periodontol 79:1585-91. 2008
    Although periodontal diseases are initiated by bacteria that colonize the tooth surface and gingival sulcus, the host response is believed to play an essential role in the breakdown of connective tissue and bone, key features of the ..
  15. ncbi Periodontal disease and coronary heart disease: a reappraisal of the exposure
    James D Beck
    Department of Dental Ecology, University of North Carolina, Chapel Hill, NC 27599, USA
    Circulation 112:19-24. 2005
    ....
  16. ncbi Periodontal disease and adverse pregnancy outcomes: a systematic review
    X Xiong
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA
    BJOG 113:135-43. 2006
    ..Recent studies suggest that periodontal disease, as a source of subclinical and persistent infection, may induce systemic inflammatory responses that increase the risk of adverse pregnancy outcomes...
  17. ncbi Metabolic syndrome, periodontal infection, and dental caries
    P Timonen
    Institute of Dentistry, University of Oulu, PO Box 5281, 90014 Oulu, Finland
    J Dent Res 89:1068-73. 2010
    ..50 (95% CI 0.96-2.36)], and carious teeth [adjusted RR 1.25 (95% CI 0.93-1.70)]. The results suggest that metabolic syndrome or some of its components are associated weakly with periodontal infection...
  18. ncbi Environmental and other modifying factors of the periodontal diseases
    Denis F Kinane
    University of Louisville School of Dentistry, Kentucky, USA
    Periodontol 2000 40:107-19. 2006
  19. ncbi Periodontal disease as a risk factor for pre-eclampsia: a case control study
    Varol Canakci
    Department of Periodontology, School of Dentistry, Ataturk University, Erzurum, Turkey
    Aust N Z J Obstet Gynaecol 44:568-73. 2004
    ..To investigate the association between periodontal disease and pre-eclampsia, while controlling known risk factors for pre-eclampsia...
  20. pmc The use of rodent models to investigate host-bacteria interactions related to periodontal diseases
    Dana T Graves
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA
    J Clin Periodontol 35:89-105. 2008
    ....
  21. pmc Association between chronic periodontal disease and obesity: a systematic review and meta-analysis
    Benjamin W Chaffee
    Division of Epidemiology, School of Public Health, University of California Berkeley, Berkeley, CA 94720 7358, USA
    J Periodontol 81:1708-24. 2010
    ..This review aims to systematically compile the evidence of an obesity-periodontal disease relationship from epidemiologic studies and to derive a quantitative summary of the association between these disease states...
  22. ncbi Inflammation and Alzheimer's disease: possible role of periodontal diseases
    Angela R Kamer
    Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY, USA
    Alzheimers Dement 4:242-50. 2008
    ..Because chronic periodontitis is a treatable infection, it might be a readily modifiable risk factor for AD...
  23. ncbi Prevalence and distribution of principal periodontal pathogens worldwide
    Mette Rylev
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Clin Periodontol 35:346-61. 2008
    ..There is evidence that some evolutionary lineages of bacteria have adapted to particular ethnic groups...
  24. ncbi Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors
    P L Wang
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka 573 1121, Japan
    Crit Rev Oral Biol Med 13:132-42. 2002
    ..In this article, we review recent findings on the signaling pathways induced by the binding of P. gingivalis LPS to CD14 and Toll-like receptors (TLRs) in gingival fibroblasts...
  25. ncbi Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study
    J D Beck
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Arterioscler Thromb Vasc Biol 21:1816-22. 2001
    ..These results provide the first indication that periodontitis may play a role in the pathogenesis of atheroma formation, as well as in cardiovascular events...
  26. pmc Diagnostic biomarkers for oral and periodontal diseases
    Mario Taba
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Dent Clin North Am 49:551-71, vi. 2005
    ..Future prospects for oral fluid-based diagnostics that use micro-array and microfluidic technologies are presented...
  27. ncbi Periodontal diseases and the risk of coronary heart and cerebrovascular diseases: a meta-analysis
    Yousef S Khader
    Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
    J Periodontol 75:1046-53. 2004
    This meta-analysis was conducted to examine the relationship between periodontal diseases and coronary heart diseases (CHD) and cerebrovascular diseases (CVD) in observational studies.
  28. ncbi Cytokine pattern determines the progression of experimental periodontal disease induced by Actinobacillus actinomycetemcomitans through the modulation of MMPs, RANKL, and their physiological inhibitors
    G P Garlet
    Department of Biochemistry and Immunology, School of Medicine USP, Ribeirao Preto, SP, Brazil
    Oral Microbiol Immunol 21:12-20. 2006
    ....
  29. pmc CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease
    Y Hosokawa
    Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Clin Exp Immunol 141:467-74. 2005
    ..This fact means that P. gingivalis may inhibit CXCR4+ cells infiltration and neovascularization in periodontal tissue and escape from the immune response...
  30. ncbi Validity and limitations of self-reported periodontal health
    Kåre Buhlin
    Department of Periodontology, Institute of Odontology, Karolinska Institutet, Huddinge, National Social Insurance Board, Stockholm, Sweden
    Community Dent Oral Epidemiol 30:431-7. 2002
    ....
  31. ncbi The impact of periodontal infection on systemic diseases
    Salomon Amar
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, U S A
    Med Sci Monit 9:RA291-9. 2003
    ..Indeed, animal and population-based studies now suggest that periodontal diseases may be linked with systemic diseases and conditions including cardiovascular diseases, diabetes, ..
  32. ncbi Relationship between metabolic syndrome and periodontal disease in Japanese adults
    Mitoshi Kushiyama
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    J Periodontol 80:1610-5. 2009
    ..Metabolic syndrome is becoming a common disorder worldwide. Studies have shown a relationship between metabolic syndrome and periodontal disease, although information on the relationship is limited...
  33. ncbi Dental biofilms: difficult therapeutic targets
    Sigmund S Socransky
    Department of Periodontology, The Forsyth Institute, Boston, Massachusetts, USA
    Periodontol 2000 28:12-55. 2002
  34. ncbi The severity of periodontal disease is associated with the development of glucose intolerance in non-diabetics: the Hisayama study
    T Saito
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    J Dent Res 83:485-90. 2004
    ..Deep pockets were closely related to current glucose tolerance status and the development of glucose intolerance...
  35. ncbi Diabetes and periodontal disease: a case-control study
    Guglielmo Campus
    Dental Institute, University of Sassari, Sassari, Italy
    J Periodontol 76:418-25. 2005
    ..This case-control study was designed to evaluate the possible association between non-insulin-dependent diabetes (T2DM) and clinical and microbiological periodontal disease among adult Sardinians...
  36. pmc Diabetes and tooth loss in a national sample of dentate adults reporting annual dental visits
    Julie M Kapp
    Department of Health Management and Informatics, University of Missouri Columbia, Columbia, MO 65211 3737, USA
    Prev Chronic Dis 4:A59. 2007
    ..Having an annual dental examination is a national goal of Healthy People 2010. Our objective was to examine whether an association exists between diabetes and tooth loss among a population reporting an annual dental visit...
  37. ncbi Diabetes and periodontal diseases: interplay and links
    Flavia Lakschevitz
    Matrix Dynamics Group, University of Toronto, Canada
    Curr Diabetes Rev 7:433-9. 2011
    The association between diabetes and periodontal diseases is well-established...
  38. ncbi Periodontal inflammation in relation to cognitive function in an older adult Danish population
    Angela R Kamer
    Department of Periodontology and Implant Dentistry, New York University College of Dentistry, New York, NY, USA
    J Alzheimers Dis 28:613-24. 2012
    ..No difference in the adjusted DST and BDT scores was seen between subjects with many missing teeth compared to those with few missing teeth. These results support the hypothesis that PI may affect cognition...
  39. ncbi Kindler syndrome: extension of FERMT1 mutational spectrum and natural history
    Cristina Has
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    Hum Mutat 32:1204-12. 2011
    ..Environmental factors and yet unidentified modifiers may play a role. Better understanding of the molecular pathogenesis of KS should enable the development of prevention strategies for disease complications...
  40. ncbi Periodontal disease increases the risk of severe pre-eclampsia among pregnant women
    Varol Canakci
    Department of Periodontology, School of Dentistry, Ataturk University, Erzurum, Turkey
    J Clin Periodontol 34:639-45. 2007
    ....
  41. ncbi HIV infection and periodontal diseases: an overview of the post-HAART era
    M Mataftsi
    Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Greece
    Oral Dis 17:13-25. 2011
    ..b>Periodontal diseases strongly associated with HIV infection are classified as linear gingival erythema, necrotizing ulcerative ..
  42. ncbi Association between metabolic syndrome and periodontal disease
    O M Andriankaja
    Center for Clinical Research and Health Promotion, School of Dental Medicine, University of Puerto Rico, San Juan, Puerto Rico
    Aust Dent J 55:252-9. 2010
    ....
  43. ncbi Periodontal diseases and the risk of preterm birth and low birth weight: a meta-analysis
    Yousef S Khader
    Department of Community Medicine, Public Health, and Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
    J Periodontol 76:161-5. 2005
    ..This meta-analysis of periodontal disease in relation to the risk of preterm birth/low birth weight (PTB/ LBW) is based on two case-control studies and three prospective cohort studies that met pre-stated inclusion criteria...
  44. ncbi Controlled release of metronidazole benzoate from poly epsilon-caprolactone electrospun nanofibers for periodontal diseases
    Maedeh Zamani
    Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
    Eur J Pharm Biopharm 75:179-85. 2010
    ..PCL) nanofibers containing metronidazole benzoate (MET) were successfully electrospun and evaluated for periodontal diseases. Solutions of 10...
  45. ncbi Relation between chronic periodontal disease and plasmatic levels of triglycerides, total cholesterol and fractions
    Ana Cristina Posch Machado
    Discipline of Oral Pathology and Oral Diagnosis, Department of Dentistry, University of Taubate
    Braz Oral Res 19:284-9. 2005
    ..4 and 117.5 mg/dl +/- 68, respectively). Therefore, this study has demonstrated that there is no significant relationship between periodontal disease, regardless of its intensity, and blood lipid levels in the studied population...
  46. pmc Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies
    S J Janket
    Department of General Dentistry, Boston University, Goldman School of Dental Medicine, 100 East Newton Street, Boston, MA 02118, USA
    J Dent Res 84:1154-9. 2005
    ..The weighted average decrease in actual HbA1c level was 0.38% for all studies, 0.66% when restricted to type 2 diabetic patients, and 0.71% if antibiotics were given to them. However, none was statistically significant...
  47. ncbi Relationship of periodontal disease and edentulism to stroke/TIA
    J R Elter
    School of Dentistry, CB7450, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    J Dent Res 82:998-1001. 2003
    ..5% of periodontal examinees, 15.6% of dentate non-examinees, and 22.5% of edentulous persons. The highest quartile of AL (OR 1.3, CI 1.02-1.7) and edentulism (OR 1.4, CI 1.5-2.0) were associated with Stroke/TIA...
  48. ncbi Relations of serum ascorbic acid and α-tocopherol to periodontal disease
    M Iwasaki
    Division of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, 2 5274 Gakkocho dori, Chuo Ku, Niigata 951 8514, Japan
    J Dent Res 91:167-72. 2012
    ..09 (0.98-1.21), and 1.15 (1.04-1.28) for α-tocopherol, respectively. Our findings support the hypothesis that low serum levels of ascorbic acid and α-tocopherol may be a risk factor for periodontal disease in Japanese elderly...
  49. ncbi Immediate efficacy of diode laser application in the treatment of dentine hypersensitivity in periodontal maintenance patients: a randomized clinical trial
    Alberto Sicilia
    Clinica Sicilia, Oviedo, Spain
    J Clin Periodontol 36:650-60. 2009
    ..To evaluate the immediate efficacy in the reduction of dentine hypersensitivity (DH) when applying an 810 nm diode laser (DL), and a 10% potassium nitrate bioadhesive gel (NK10%)...
  50. ncbi The effect of written information on pain experience during periodontal probing
    Arjen J van Wijk
    Department of Social Dentistry and Dental Health Education, Academic Centre for Dentistry Amsterdam ACTA, The Netherlands
    J Clin Periodontol 31:282-5. 2004
    ..To study the effect of providing written information prior to periodontal treatment on the pain experience during periodontal probing...
  51. ncbi Local delivery of antimicrobial agents for the treatment of periodontal diseases
    K Schwach-Abdellaoui
    School of Pharmacy, University of Geneva, Geneva, Switzerland
    Eur J Pharm Biopharm 50:83-99. 2000
    ..Despite the large number of studies showing an enhanced effectiveness of local antibiotherapy, there are insufficient comparative data to support any of the local delivery system...
  52. ncbi Maternal periodontal disease in early pregnancy and risk for a small-for-gestational-age infant
    Kim A Boggess
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA
    Am J Obstet Gynecol 194:1316-22. 2006
    ..The objective of the study was to determine whether periodontal disease is associated with delivery of a small-for-gestational-age infant...
  53. ncbi Bactericidal effect of malachite green and red laser on Actinobacillus actinomycetemcomitans
    Renato Araujo Prates
    Center for Lasers and Applications, IPEN CNEN SP, Av Prof Lineu Prestes, 2242, Cidade Universitaria, São Paulo SP 05508 000, Brazil
    J Photochem Photobiol B 86:70-6. 2007
    ..Optical absorption showed that MG is photobleached after irradiation. These results indicate that A. actinomycetemcomitans can be photosensitized by red laser combined with MG and that the dye is photodegraded following irradiation...
  54. ncbi The oral health of psychiatric in-patients in South Wales
    S Lewis
    Department of Adult Dental Health, University of Wales College of Medicine, Heath Park, Cardiff CF144XY, Wales, UK
    Spec Care Dentist 21:182-6. 2001
    ..The oral hygiene of the dentate population was poor, and there was little periodontal disease. Treatment needs were mainly for scaling and polishing. There were no significant differences found between subgroups within the population...
  55. pmc Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats
    Brian Bainbridge
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    Infect Immun 78:4560-9. 2010
    ..In conclusion, in a rat model of periodontal disease, the SerB phosphatase of P. gingivalis is required for maximal alveolar bone resorption, and in the absence of SerB, more PMNs are recruited into the gingival tissues...
  56. ncbi Update on general health risk of periodontal disease
    Jørgen Slots
    University of Southern California, School of Dentistry, Los Angeles 90089 0641, USA
    Int Dent J 53:200-7. 2003
    ..To review the potential of periodontal infections to cause nonoral diseases. Therapeutic recommendations are provided to help patients and dental practitioners prevent systemic complications from periodontal infections...
  57. ncbi Preterm low birth weight and maternal periodontal status: a meta-analysis
    Jean Noel Vergnes
    Department of Epidemiology, Dental School, Toulouse, France
    Am J Obstet Gynecol 196:135.e1-7. 2007
    ..This study was undertaken to assess the effect of maternal periodontal disease on preterm delivery and/or birth of low-weight infants...
  58. ncbi The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes
    Y Iwamoto
    Department of Periodontology and Endodontology, Okayama University Dental School, Japan
    J Periodontol 72:774-8. 2001
    ..49 pg/ml and 0.8%, respectively. CONCLUSION: The results indicate that anti-infectious treatment is effective in improving metabolic control in diabetics, possibly through reduced serum TNF-alpha and improved insulin resistance...
  59. ncbi Potential associations between chronic respiratory disease and periodontal disease: analysis of National Health and Nutrition Examination Survey III
    F A Scannapieco
    Department of Oral Biology, University at Buffalo, State University of New York, 14214, USA
    J Periodontol 72:50-6. 2001
    ....
  60. ncbi Calprotectin in gingival crevicular fluid correlates with clinical and biochemical markers of periodontal disease
    J Kido
    Department of Periodontology and Endodontology, Tokushima University School of Dentistry, Kuramoto, Japan
    J Clin Periodontol 26:653-7. 1999
    ..These results indicate that the calprotectin level in GCF correlates well with clinical and biochemical markers of periodontal disease and suggest that calprotectin may be useful for evaluating the extent of periodontal inflammation...
  61. ncbi Periodontal health, oral health behaviours, and chronic obstructive pulmonary disease
    Zuomin Wang
    Department of Stomatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
    J Clin Periodontol 36:750-5. 2009
    ..To evaluate the associations of periodontal health status and oral health behaviours with chronic obstructive pulmonary disease (COPD)...
  62. pmc The relationship of the oral microbiotia to periodontal health and disease
    Michael A Curtis
    Centre for Immunology and Infectious Disease, Blizard Institute, Barts and The London, Queen Mary University of London, London E1 2AT, UK
    Cell Host Microbe 10:302-6. 2011
    ..However, additional studies are needed to elucidate the mechanisms that define these microbial/host relationships...
  63. ncbi Cigarette smoking and periodontal diseases: etiology and management of disease
    M S Tonetti
    Department of Periodontal and Fixed Prosthodontics, School of Dental Medicine, University of Berne, Switzerland
    Ann Periodontol 3:88-101. 1998
    Cigarette smoking has long been suspected to be associated with a variety of oral conditions including periodontal diseases. Experimental evidence accumulated over the last 2 decades has indicated that cigarette smoking is probably a true ..
  64. ncbi Melatonin in diseases of the oral cavity
    G Gomez-Moreno
    School of Dentistry, University of Granada, Granada, Spain
    Oral Dis 16:242-7. 2010
    ..As a result of these actions, melatonin may be useful as a co-adjuvant in the treatment of certain conditions of the oral cavity...
  65. ncbi Periodontal disease and mortality in type 2 diabetes
    Aramesh Saremi
    National Institute of Diabetes and Digestive and Kidney Disease, Phoenix, Arizona, USA
    Diabetes Care 28:27-32. 2005
    ..Periodontal disease may contribute to the increased mortality associated with diabetes...
  66. ncbi A systematic review of stress and psychological factors as possible risk factors for periodontal disease
    Daiane C Peruzzo
    Division of Periodontics, School of Dentistry at Piracicaba, State University of Campinas, Piracicaba, SP, Brazil
    J Periodontol 78:1491-504. 2007
    ..The focused question addressed in this systematic review was whether the scientific evidence is enough to consider stress and psychological factors as risk factors for periodontal disease...
  67. ncbi Melatonin: potential functions in the oral cavity
    Antonio Cutando
    Department of Special Care in Dentistry, School of Dentistry, University of Granada, Granada, Spain
    J Periodontol 78:1094-102. 2007
    ..Melatonin has powerful antioxidant effects, functions in an immunomodulatory role, may protect against certain cancers, delays some age-related processes, stimulates the synthesis of type I collagen fibers, and promotes bone formation...
  68. ncbi Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation
    Salomon Amar
    Department of Periodontology, Boston University School of Dental Medicine, Mass, USA
    Arterioscler Thromb Vasc Biol 23:1245-9. 2003
    ..Epidemiological studies suggest that severe periodontal disease is associated with increased cardiovascular disease risk, but the mechanisms remain unknown...
  69. ncbi Associations between periodontal diseases and systemic diseases: a review of the inter-relationships and interactions with diabetes, respiratory diseases, cardiovascular diseases and osteoporosis
    Lan Chen Kuo
    School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Public Health 122:417-33. 2008
    The aim of this review article is to examine the associations between periodontal diseases and common systemic diseases, namely diabetes, respiratory diseases, cardiovascular diseases and osteoporosis...
  70. ncbi Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease
    L Montebugnoli
    Department of Oral Science, University of Bologna, Bologna, Italy
    J Clin Periodontol 32:188-92. 2005
    ..The present study was performed to assess whether intensive dental care may produce a periodontal improvement along with a change in systemic inflammatory and haemostatic factors...
  71. ncbi Maternal periodontal disease is associated with an increased risk for preeclampsia
    Kim A Boggess
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Obstet Gynecol 101:227-31. 2003
    ..To determine if maternal periodontal disease is associated with the development of preeclampsia...
  72. pmc Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study
    Ryan T Demmer
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA
    Diabetes Care 31:1373-9. 2008
    ..We investigated whether baseline periodontal disease independently predicts incident diabetes over two decades of follow-up...
  73. ncbi Potential for gingival crevice fluid measures as predictors of risk for periodontal diseases
    Catherine M E Champagne
    Periodontol 2000 31:167-80. 2003
  74. pmc Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST)
    Moise Desvarieux
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    J Hypertens 28:1413-21. 2010
    ..Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and hypertension...
  75. pmc Tooth loss and periodontal disease predict poor cognitive function in older men
    Elizabeth Krall Kaye
    Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    J Am Geriatr Soc 58:713-8. 2010
    ..To determine whether rates of tooth loss, periodontal disease progression, and caries incidence predict cognitive decline in men...
  76. ncbi The miniature pig: a useful large animal model for dental and orofacial research
    S Wang
    Salivary Gland Disease Center and Molecular Laboratory for Gene Therapy, Capital Medical University School of Stomatology, Beijing, China
    Oral Dis 13:530-7. 2007
    ..In this review, we describe the anatomical characteristics of the oral maxillofacial system of the miniature pig, established models of oral diseases in this animal, and other uses of the miniature pig in orofacial research...
  77. ncbi Matrix metalloproteinases, their physiological inhibitors and osteoclast factors are differentially regulated by the cytokine profile in human periodontal disease
    Gustavo P Garlet
    Department of Biochemistry and Immunology, University of Ribeirao Preto UNAERP, Dentistry School, Av Bandeirantes 3900, 14049 900 Ribeirao Preto, SP, Brazil
    J Clin Periodontol 31:671-9. 2004
    ..their respective tissue inhibitors of metalloproteinases (TIMPs) and osteoprotegerin (OPG) in different forms of human periodontal diseases (PDs), and the possible correlation with the expression of inflammatory and regulatory cytokines.
  78. ncbi Comparison of body composition and periodontal disease using nutritional assessment techniques: Third National Health and Nutrition Examination Survey (NHANES III)
    Nelson Wood
    Department of Periodontics, University of Mississippi School of Dentistry, 2500 North State Street, Jackson, MS 39216 4505, USA
    J Clin Periodontol 30:321-7. 2003
    ....
  79. ncbi Association between periodontal disease and acute myocardial infarction
    G Emingil
    School of Dentistry, Department of Periodontology, Ege University, Izmir, Turkey
    J Periodontol 71:1882-6. 2000
    ..The aim of the present study was to investigate the possible association between periodontal health and coronary heart disease in patients with acute myocardial infarction and chronic coronary heart disease...
  80. ncbi Treatment of periodontal disease and control of diabetes: an assessment of the evidence and need for future research
    S G Grossi
    Periodontal Disease Research Center, Department of Oral Biology, School of Dental Medicine, The University at Buffalo, Buffalo, New York, USA
    Ann Periodontol 6:138-45. 2001
    ..The evidence supports the notion that treatment of chronic periodontal infection is essential in the diabetic patient. Assessment of infection status in diabetic patients is fundamental for appropriate treatment decisions...
  81. ncbi Global risk factors and risk indicators for periodontal diseases
    Jasim M Albandar
    Periodontol 2000 29:177-206. 2002
  82. ncbi Oral health needs among adults in the United States with chronic diseases
    Susan O Griffin
    Surveillance, Investigations, and Research Branch, Division of Oral Health, Centers for Disease Control and Prevention, Chamblee, GA 30341, USA
    J Am Dent Assoc 140:1266-74. 2009
    ..Oral and dental diseases may be associated with other chronic diseases...
  83. ncbi Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review
    Frank A Scannapieco
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, New York, USA
    Ann Periodontol 8:54-69. 2003
    ..Several recent studies provide evidence that the oral cavity may influence the initiation and/or the progression of lung diseases such as pneumonia and chronic obstructive pulmonary disease (COPD)...
  84. ncbi Periodontal disease and systemic health: current status
    M P Cullinan
    Faculty of Dentistry, University of Otago, Dunedin, New Zealand
    Aust Dent J 54:S62-9. 2009
    ..This review provides an update on current understanding of the contribution of poor oral health to systemic diseases, the possible mechanisms involved and the relevance of this for general dental practitioners...
  85. ncbi Periodontal diseases and osteoporosis: association and mechanisms
    J Wactawski-Wende
    Departments of Social and Preventive Medicine and Gynecology and Obstetrics, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA
    Ann Periodontol 6:197-208. 2001
    ..This paper reviews the current evidence on the association between periodontal disease and osteoporosis...
  86. ncbi Role of bacteria in health and disease of periodontal tissues
    Zhimin Feng
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Periodontol 2000 40:50-76. 2006
  87. ncbi Cigar, pipe, and cigarette smoking as risk factors for periodontal disease and tooth loss
    J M Albandar
    Department of Periodontology, Temple University School of Dentistry, Philadelphia, PA 19140, USA
    J Periodontol 71:1874-81. 2000
    ..We also investigated whether a history of smoking habits cessation may affect the risk of periodontal disease and tooth loss...
  88. ncbi Quantitative real-time PCR using TaqMan and SYBR Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, tetQ gene and total bacteria
    Hiroshi Maeda
    Department of Patho physiology, Division of Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    FEMS Immunol Med Microbiol 39:81-6. 2003
    Accurate quantification of bacterial species in dental plaque is needed for microbiological diagnosis of periodontal diseases. The present study was designed to assess the sensitivity, specificity and quantitativity of the real-time PCR ..
  89. ncbi Clinical and serologic markers of periodontal infection and chronic kidney disease
    Monica A Fisher
    Department of Orthodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA
    J Periodontol 79:1670-8. 2008
    ..Chronic kidney disease and its concomitant sequelae represent a major public health problem. Recent data suggest periodontal infection contributes to chronic kidney disease...
  90. ncbi Periodontal regeneration techniques for treatment of periodontal diseases
    Hom Lay Wang
    Department of Periodontics Prevention Geriatrics, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Dent Clin North Am 49:637-59, vii. 2005
    ..Various materials/agents such as bone replacement grafts, barrier membranes, and biologic modifiers currently used for the regeneration of periodontal infrabony and furcation defects are discussed...
  91. ncbi The relationship between infections and chronic respiratory diseases: an overview
    M S Terpenning
    Department of Internal Medicine, Department of Veterans Affairs, Ann Arbor, Michigan, USA
    Ann Periodontol 6:66-70. 2001
    ..An overview of respiratory disease and some of the factors that can contribute to respiratory infection is presented below, with special reference to infections related to aspiration...
  92. ncbi Clinical studies on the management of periodontal diseases utilizing subantimicrobial dose doxycycline (SDD)
    Jack Caton
    Department of Periodontology, Eastman Institute for Oral Health, University of Rochester, 625 Elmwood Avenue, Rochester, NY 14620, USA
    Pharmacol Res 63:114-20. 2011
    ....
  93. ncbi Diagnosis and classification of periodontal disease
    J Highfield
    Discipline of Periodontics, Faculty of Dentistry, The University of Sydney, New South Wales, Sydney, Australia
    Aust Dent J 54:S11-26. 2009
    b>Periodontal diseases have been recognized and treated for at least 5000 years...
  94. ncbi Relationship between periodontal disease and osteoporosis
    Emma Megson
    Colgate Australian Clinical Dental Research Centre, Dental School, University of Adelaide, Adelaide, South Australia, Australia
    Int J Evid Based Healthc 8:129-39. 2010
    ..For many years an association between the low bone density of osteoporosis and increased risk of periodontal bone loss has been suspected. In this review the relationship between osteoporosis and periodontal disease is considered...
  95. ncbi Priorities for research for oral health in the 21st century--the approach of the WHO Global Oral Health Programme
    Poul Erik Petersen
    Oral Health Programme, World Health Organization, Department for Chronic Disease and Health Promotion, Geneva, Switzerland
    Community Dent Health 22:71-4. 2005
    ..Building and strengthening research capacity in public health are highly recommended by WHO for effective control of disease and the socioeconomic development of any given country...
  96. ncbi Understanding and managing periodontal diseases: a notable past, a promising future
    Ray C Williams
    Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Periodontol 79:1552-9. 2008
    ..Clearly, the 21st century has arrived with a new understanding of the nature of periodontal diseases based on a notable era of discovery...
  97. ncbi Pain experienced by patients during periodontal maintenance treatment
    Hildur Karadottir
    Advanced Education Program in Periodontics and Implant Surgery, School of Dentistry, Loma Linda University, CA, USA
    J Periodontol 73:536-42. 2002
    ....
  98. ncbi Microbiology of periodontal diseases: introduction
    Anne D Haffajee
    Department of Periodontology, The Forsyth Institute, Boston, MA, USA
    Periodontol 2000 38:9-12. 2005
  99. ncbi Periodontal disease and pregnancy outcomes: state-of-the-science
    Xu Xiong
    Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA
    Obstet Gynecol Surv 62:605-15. 2007
    ....
  100. ncbi Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases
    Bhimrao K Jadhav
    Department of Pharmacognosy, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra State, India
    Drug Dev Ind Pharm 30:195-203. 2004
    ..The release kinetics of eugenol in vitro correlates with the in vivo results. This indicates the increased potential of eugenol as antibacterial, local analgesic, and anaesthetic treatment...
  101. ncbi Association between periodontal diseases and systemic diseases
    Patricia Weidlich
    Department of Periodontology, Federal University of Rio Grande do Sul, Brazil
    Braz Oral Res 22:32-43. 2008
    ..Further studies, particularly interventional well-designed investigations, with larger sample sizes, need to be conducted in Brazilian populations...

Research Grants63

  1. CONTROL OF PERIODONTAL INFECTIONS
    Sigmund Socransky; Fiscal Year: 2003
    b>Periodontal diseases are infectious diseases caused by the microorganisms that exist at or below the gingival margin. As such, the optimum method for their control logically lies in the elimination or suppression of the etiologic species...
  2. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..First, we will test the ability of SAGEs to inhibit inflammatory events relevant to periodontal diseases in vitro, including biofilm formation by Porphyromonas gingivalis, cytokine production by LPS- or AGE-..
  3. Studies on the virulence of Fillifactor alocis
    Hansel M Fletcher; Fiscal Year: 2013
    ..emerging from the oral microbiome project is facilitating a shift in the paradigm for infection-induced periodontal diseases. Bacteria like Porphyromonas gingivalis, Prevotella intermedia, Aggregatibacter (Actinobacillus) ..
  4. Click chemistry for novel antimicrobials against periodontal pathogens
    Valery V Fokin; Fiscal Year: 2010
    ..b>Periodontal diseases affect a large segment of the American public, with over 50% of adults having gingivitis and 5-15% having a ..
  5. Periodontal Pathogens and Cardiovascular Disease
    KESAVALU NAIDU LAKSHMYYA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontal diseases are among the most common chronic polymicrobial infections of mankind and a substantial amount of epidemiological data is accumulating linking periodontal disease with increased ..
  6. Inhibited Intramembranous Bone Healing in Diabetes
    Philip C Trackman; Fiscal Year: 2013
    ..become weak, resulting in diminished mobility, increased risk of foot and other fractures, more severe periodontal diseases, and a generally diminished quality of life...
  7. INTERPLAYS BETWEEN THE JAW MESENCHYMAL STEM CELLS AND T LYMPHOCYTES
    Yufang Shi; Fiscal Year: 2010
    ..Immune diseases target the orofacial bones with specific phenotypes as seen in periodontal diseases, cherubism, and hyperparathyroid jaw tumor syndrome...
  8. Tannerella forsythia intercations with host cells and other bacteria
    Ashu Sharma; Fiscal Year: 2012
    ..The studies proposed in this application are aimed at understanding the mechanisms of BspA-induced pathogenesis in periodontal disease and will be vital in developing therapeutic strategies against periodontal diseases in future.
  9. Modulation of epithelial cell response by P. gingivalis
    Ozlem Yilmaz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontal diseases are prevalent destructive oral polymicrobial infections that remain a significant public health burden...
  10. Biomarkers of Periodontal Disease Progression
    Ricardo P Teles; Fiscal Year: 2013
    ..b>Periodontal diseases are the most common cause of tooth loss among adults in the United States and recent studies suggested that ..
  11. New Technologies to Identify Novel Periodontal Pathogens
    FLAVIA ROCHA TELES; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Periodontal diseases affect 35% of US adults and lead to bone and tooth loss. Treatment costs reach U$ 4.4 billion per year to American taxpayers...
  12. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2009
    ..in the periodontal pocket, and (ii) acting as a cytotoxin to produce some of the tissue damage seen in periodontal diseases. To begin to test these hypotheses, we propose (Aim 1) to complete the purification and enzymatic ..
  13. MOLECULAR BIOLOGY OF VIRULENCE IN PERIODONTAL DISEASE
    EDWARD THOMAS LALLY; Fiscal Year: 2012
    ..actinomycetemcomitans (Aa) is a facultative anaerobe that has been implicated in a variety of periodontal diseases. Its presence is most closely associated with localized aggressive periodontitis (LAP), a disease which ..
  14. Low pH-mediated membrane biosynthesis in S. mutans.
    Robert G Quivey; Fiscal Year: 2010
    ..Caries and periodontal diseases are considered to be the most prevalent diseases in the industrialized world...
  15. A novel glycosylation-associated protein is required for fimbriae biogenesis
    Haley L Echlin; Fiscal Year: 2013
    ..as a necessary platform for other microbial cells to attac and form a biofilm, including those that cause periodontal diseases. Therefore, the initial binding of sanguis streptococci to the oral cavity has significant implications for ..
  16. Nanoparticle-based Antimicrobial Photochemotherapy in Biofilms
    NIKOLAOS SOUKOS; Fiscal Year: 2010
    ..sulcus (subgingival dental plaques) are among the most complex biofilms that exist in nature and lead to periodontal diseases. Our long-term goal is to develop a clinically appropriate way to enhance the penetration and effectiveness ..
  17. Two-way Interrelationships: Periodontal Disease, Diabetes and its Complications
    George Taylor; Fiscal Year: 2009
    ..in the VANAS/DLS data analyses, to evaluate the bidirectional relationships between diabetes and periodontal diseases as well as the relationship between periodontal disease and the prevalence and incidence of poorer glycemic ..
  18. Small non-coding RNAs in Porphyromonas gingivalis
    JANINA P contact LEWIS; Fiscal Year: 2010
    ..clues how the bacterium tolerates various environments and ultimately, we predict that this work will lead to identification of targets for the design of novel and specific therapeutic agents for treatment of periodontal diseases.
  19. A Dual-drug Delivery to Inhibit Causes of Periodontal Diseases
    RAJIV KUMAR SATSANGI; Fiscal Year: 2012
    ..Thus, the chances of success of this product in successfully treating the periodontal disease are high. ..
  20. Porphyromonas gingivalis lipids mediate bone loss through TLR2
    Frank C Nichols; Fiscal Year: 2013
    ..gingivalis promotes bone loss in periodontal diseases and may provide another mechanistic explanation for bone loss associated with common systemic diseases such ..
  21. MMP-2 and Fibronectin Fragmentation in Periodontal Diseases and Oral Cancer
    Bjorn Steffensen; Fiscal Year: 2010
    ..Successful inhibition of fibronectin fragmentation could be of significant benefit for the management of both periodontal disease and oral cancer. ..
  22. Protein-protein covalent bonding and Treponema motility
    Michael R Miller; Fiscal Year: 2013
    ..provided by applicant): Treponema denticola (Td) is strongly implicated as a major participant in periodontal diseases, which cause tooth loss and are implicated in systemic diseases including cardiovascular disease...
  23. Investigation of FadA adhesin from Fusobacterium nucleatum
    Yiping Han; Fiscal Year: 2013
    Fusobacterium nucleatum is a Gram-negative anaerobe implicated in various forms of periodontal diseases. It is also associated with infections in other parts of the body and is one of the most prevalent species in intra- amniotic ..
  24. Role of JAK2 in Innate Immunity
    Richard J Lamont; Fiscal Year: 2013
    ..provided by applicant): Porphyromonas gingivalis is considered to be one of the major etiologic agents of periodontal diseases. Studies assessing the host inflammatory response to P...
  25. Therapeutic Strategies for Treating Type 2 Diabetes Mellitus -Associated Periodon
    Jake Jinkun Chen; Fiscal Year: 2013
    ..Diabetic periodontal diseases are more severe and refractory because T2DM and obesity trigger the release of excess inflammatory factors, ..
  26. Exploring New Virulence Factors of the Oral Spirochete Treponema denticola
    Chunhao Li; Fiscal Year: 2013
    ..project will advance our current understanding of the pathogenicity of Td, in particular, the mechanisms involved in the innate immune evasion, which could potentially lead to new therapeutic interventions against periodontal diseases.
  27. Inhibition of P. gingivalis Biofilm Formation by a Streptococcal Effector Protein
    Carla Cugini; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontal diseases are biofilm-induced pathologies mediated by out-growth of commensal pathogens that live within a complex microbial community in the oral cavity...
  28. AI-2-dependent quorum sensing in Aggregatibacter actinomycetemcomitans
    ELIZABETH ANN NOVAK; Fiscal Year: 2012
    ..actinomycetemcomitans. Since periodontal diseases are mixed bacterial infections of the oral cavity, it is theorized that populational shifts in the biofilm ..
  29. Carbohydrate Receptors, Preterm Labor, and Periodontitis
    Wenge Ma; Fiscal Year: 2009
    ..information could be used to design novel therapies for the prevention or treatment of preterm labor and periodontal diseases. By carrying out this research plan and completing a program in Periodontology, the candidate will receive ..
  30. The Effect of Statin on Diabetes-Associated Peridontal Disease
    Yan Huang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The recent workshop on inflammation and periodontal diseases organized by American Academy of Periodontology (AAP) has proposed "use of statins and targeted anti-inflammatory therapies in patients ..
  31. Interaction of Colonizer and Pathogen In Oral Biofilm
    Ping Xu; Fiscal Year: 2013
    ..Oral biofilm is important for periodontal diseases in which pioneers provide substrates allowing colonization of subsequent pathogens...
  32. Raman/OCT probe for real-time assessment of oral health status
    Nicusor Iftimia; Fiscal Year: 2013
    ..Coherence Tomography (OCT) imaging for in vivo diagnosis of tooth decay, cracks, and periodontal diseases. Both Raman and OCT are powerful technologies with proven success in human tissue diagnosis while avoiding ..
  33. P.gingivalis Interactions with Gingival Epithelial Cells
    Richard J Lamont; Fiscal Year: 2013
    b>Periodontal diseases are one of the most common bacterial infections of humans and impose a significant burden on the health care system. One of the predominant pathogens in periodontal disease is the gram- negative anaerobe P...
  34. Developing Inhibitors of LuxS-dependent Quorum Sensing Systems in Oral Bacteria
    Chunhao Li; Fiscal Year: 2013
    ..Thus, LuxS can be a potential target for developing therapeutic agents to prevent or treat periodontal diseases. The goal of this application is to develop LuxS-based therapeutic compounds that specifically inhibit the ..
  35. Epithelial Cell Function in the Progression of Periodontal Disease
    SHANNON MARGARET WALLET; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontal diseases are a class of inflammatory diseases which if left untreated can result in soft and hard tissue destruction...
  36. MicroRNA expression in gingival tissues in periodontal health and disease
    Panos N Papapanou; Fiscal Year: 2013
    ..The proposed studies will address a significant gap in knowledge in a cost-effective manner and in a short period of time, and will advance our understanding of the pathobiology of periodontal diseases.
  37. Impact of Oral bacterial interactions on periodontitis
    Eric Reynolds; Fiscal Year: 2004
    b>Periodontal diseases are bacterial-associated inflammatory diseases of the supporting tissues of the teeth, and one of the more aggressive forms of chronic periodontitis is characterized by the destruction of the tooth's supporting ..
  38. Developmental Disabilities Dentistry Online
    Richard K Fleming; Fiscal Year: 2013
    ..disabilities (I/DD) have "more untreated caries and a higher prevalence of gingivitis and other periodontal diseases than the general population" (NIDCR, 2009)...
  39. Specialized Center for Oral Inflammation and Resolution
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    Oral infections lead to local persistent inflammation that when "uncontrolled" gives rise to periodontal diseases (PD), a costly public health burden...
  40. IDENTIFY ANTIGENIC DETERMINANTS OF HUMAN PERIODONTITIS
    YEN TUNG TENG; Fiscal Year: 2001
    Human periodontal diseases (e.g., periodontitis) are heterogeneous and result from specific bacteria-host immune interactions...
  41. Molecular analysis of F. nucleatum interspecies interactions in biofilms
    Wenyuan Shi; Fiscal Year: 2013
    ..microbial biofilm community capable of mediating acute and chronic polymicrobial infections including periodontal diseases which are still the most common reason for tooth loss worldwide...
  42. Surface protein complexes of oral treponemes: assembly and host cell interactions
    J Christopher Fenno; Fiscal Year: 2010
    ..molecular biology and to understanding of microbe-host interactions in chronic infections such as periodontal diseases. Public Health Significance: This project will provide information on how a key bacterium involved in ..
  43. T-COHR: Summer Undergraduate Research Program
    Keith L Kirkwood; Fiscal Year: 2013
    ..The Program Faculty have been selected on the basis of their active research programs in the areas of periodontal diseases, oral infectious diseases, craniofacial development, oral cancer biology and oral microbiology...
  44. Pathogenic mechanisms of F. alocis
    Richard J Lamont; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontal diseases are one of the most common bacterial infections of humans and impose a significant burden on the health care system...
  45. Biofilm Architecture of Subgingival Plaque
    Renate Lux; Fiscal Year: 2009
    A significant number of the adult population world-wide is affected by periodontal diseases. These chronic biofilm infections of the tooth-supporting tissues that are the major cause of tooth loss have also been associated with systemic ..
  46. In situ analysis of bacterial biosynthetic activity in subgingival plaque
    Gerard A Cangelosi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Periodontal diseases are induced by communities of subgingival bacteria and result in destruction of supporting structures of the teeth...
  47. Oral Microbial Biomarkers in Periodontal Disease Progression
    Bruce J Paster; Fiscal Year: 2013
    ..This addresses a significant health-related problem in that periodontal diseases are bacterial infections that affect over half of the US adult population and are responsible for half of ..
  48. DIABETES AND PERIODONTITIS MICROBIOLOGY AND IMMUNOLOGY
    JEROME HABER; Fiscal Year: 1990
    b>Periodontal diseases afflict many individuals and are the major cause of tooth loss in adults...
  49. Individual Predoctoral Dental Scientist Fellowship
    Jeremy A Horst; Fiscal Year: 2010
    The overarching goal of the thesis project is to develop technologies to infer pathways implicated in periodontal diseases and tissue regeneration...
  50. PERIODONTAL DISEASES: B CELLS ACTIVATED BY MITOGENS
    JAMES CLAGETT; Fiscal Year: 1980
    ....
  51. Importance of Periostin in Periodontal Homeostasis and Pathogenesis
    Hector F Rios; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Periodontal diseases affect a large proportion of the world's population...
  52. GENETICS OF ANTIBODIES TO PERIODONTAL PATHOGENS
    JEROME HABER; Fiscal Year: 1990
    Caries and periodontal diseases afflict most individuals at some time during life and are the major causes of tooth loss in all age groups. The factors which determine resistance or susceptibility to these diseases are unknown...
  53. ORAL INFECTIONS AND VASCULAR RISK IN SEVEN COUNTRIES
    Moise Desvarieux; Fiscal Year: 2001
    ..is unique in that it will allow parallel testing of hypothesis in populations, with varying degrees of periodontal diseases and cardiovascular diseases, using a standard protocol for measurements of putative exposures and outcomes, ..
  54. CULTIVABLE & UNCULTIVABLE PERIODONTAL SPIROCHETES
    Floyd Dewhirst; Fiscal Year: 2003
    ..There is substantial evidence implicating spirochetes, particularly T denticola, as etiologic agents in periodontal diseases. In acute necrotizing ulcerative gingivitis (ANUG) and some forms of periodontal disease, spirochetes may ..
  55. Role of Zonula Occludens Toxin in the Pathogenesis of Treponema denticola
    Chunhao Li; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Periodontal diseases are a group of infections that affect the structures surrounding teeth, mainly including gingivitis and periodontitis...
  56. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2007
    ..as an important member of a consortium of microorganisms as etiologic in the initiation and progression of periodontal diseases. In addition, the existence of volatile sulfur compounds produced at destructive sites is a characteristic ..
  57. Treatment of Periodontitis and Inflammatory Changes in Diabetes
    Hatice Hasturk; Fiscal Year: 2012
    ..of life outcomes, with a special focus on the study of clinical interventional study of the relationship of periodontal diseases and diabetes and especially the impact of periodontal treatment on the control of the diabetic ..
  58. T CELL REGULATION OF CARIES IMMUNITY/PERIODONTAL DISEASE
    Hiroshi Kiyono; Fiscal Year: 1992
    ..actinomycetemcomitans (Ha) play important roles in the development of gingival tissue destruction in periodontal diseases. It has also been shown that oral administration of Streptococcus mutans vaccine to human induces antigen-..
  59. BIOSENSOR FOR DIAGNOSIS OF PERIODONTAL DISEASES
    Bill Colston; Fiscal Year: 2001
    ..The applicability is, therefore, not solely limited to dentistry and the device would be important both for clinical diagnostics and as a research tool. ..
  60. INTERACTION OF ORAL BACTERIA WITH PERIODONTAL TISSUES
    Jorgen Slots; Fiscal Year: 1990
    In order to effectively and efficiently control periodontal diseases on an individual and a public health level, a better understanding of the specific etiology and pathogenesis of the disorders must be obtained...
  61. The OppA PEPTIDE Permease HOMOLOGUE OF ORAL SPIROCHETES
    J Fenno; Fiscal Year: 2001
    ..proteins of Treponema denticola mediate interactions between the spirochete and sub-gingival tissues in periodontal diseases. Proteins having direct cytopathic effects have been a primary focus of research...
  62. Innate Immune Response Genes and P. Gingivalis
    Jenny Ting; Fiscal Year: 2009
    DESCRIPTION: Periodontal diseases are associated with pathogenic bacteria which colonize the subgingival area. Inflammatory responses mediated by cells of the innate immune system are critical determinants of periodontal diseases...
  63. GINGIVAL EPITHELIAL CELL ANTIMICROBIAL PEPTIDES
    Aaron Weinberg; Fiscal Year: 2002
    ..oral cavity are constantly exposed to a variety of microbial challenges that lead to bacterially induced periodontal diseases and other infections...