tongue neoplasms

Summary

Summary: Tumors or cancer of the TONGUE.

Top Publications

  1. ncbi Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer
    Ibrahim O Bello
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu FI 90014, Finland
    Oral Oncol 47:33-8. 2011
  2. ncbi Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma
    Marilena Vered
    Institute of Pathology Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
    Int J Cancer 127:1356-62. 2010
  3. ncbi MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor
    Jinsong Li
    Oral and Maxillofacial Surgery, and Breast Tumor Center, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    Clin Cancer Res 15:3998-4008. 2009
  4. ncbi Metastasis of squamous cell carcinoma of the oral tongue
    Daisuke Sano
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Unit 441, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Cancer Metastasis Rev 26:645-62. 2007
  5. ncbi Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice
    Xiao Han Tang
    Departments of Pharmacology and Pathology, Weill Medical College of Cornell University, New York, New York
    Clin Cancer Res 10:301-13. 2004
  6. pmc A novel organotypic model mimics the tumor microenvironment
    Sini Nurmenniemi
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
    Am J Pathol 175:1281-91. 2009
  7. ncbi Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both
    James T Parsons
    Department of Radiation Oncology, Bethesda Memorial Hospital, Boynton Beach, Florida, USA
    Cancer 94:2967-80. 2002
  8. ncbi The mushroom-shaped anterolateral thigh perforator flap for subtotal tongue reconstruction
    Benedetto Longo
    Plastic Surgery Unit, Sant Andrea Hospital, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
    Plast Reconstr Surg 132:656-65. 2013
  9. ncbi Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production
    K Sumitani
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan
    J Oral Pathol Med 30:41-7. 2001
  10. ncbi The incidence of oropharyngeal cancer in Taiwan: an endemic betel quid chewing area
    Pei Shian Ho
    Graduate Institute of Dental Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Oral Pathol Med 31:213-9. 2002

Research Grants

  1. Origins of Spontaneous Mutagenesis
    Joseph Guttenplan; Fiscal Year: 2005
  2. HPV Oral-Pharyngeal Study
    Laura A Koutsky; Fiscal Year: 2010
  3. Fiber Optic In Vivo Confocal Microscopy
    Rebecca Richards Kortum; Fiscal Year: 2005
  4. Fiber Optic In Vivo Confocal Microscopy
    Rebecca Richards Kortum; Fiscal Year: 2002
  5. The 7th International Conference on Head and Neck Cancer
    Jeffrey Myers; Fiscal Year: 2008
  6. HYPOXIC IMAGING GUIDED INTENSITY MODULATED RADIOTHERAPY
    KS CLIFFORD CHAO; Fiscal Year: 2003
  7. Early Prediction of Pathological Response of Chemoradiotherapy with FLT PET
    KS CLIFFORD CHAO; Fiscal Year: 2007
  8. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2004
  9. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
  10. Adenoviral GFP targeting of metastatic human tumors using multiple delivery route
    Hiroyuki Kishimoto; Fiscal Year: 2008

Detail Information

Publications261 found, 100 shown here

  1. ncbi Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer
    Ibrahim O Bello
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu FI 90014, Finland
    Oral Oncol 47:33-8. 2011
    ..Given the strong association between increased CAF density and higher mortality in MTSCC, routine assessment of CAF density for disease course prognosis and inclusion as an integral part of treatment protocols are recommended...
  2. ncbi Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma
    Marilena Vered
    Institute of Pathology Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel
    Int J Cancer 127:1356-62. 2010
    ..Evidence of EMT is common within primary tumors and metastatic SCC and may be further modulated by CAFs...
  3. ncbi MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor
    Jinsong Li
    Oral and Maxillofacial Surgery, and Breast Tumor Center, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, People s Republic of China
    Clin Cancer Res 15:3998-4008. 2009
    ..We aim to examine miR-21 expression in tongue squamous cell carcinomas (TSCC) and correlate it with patient clinical status, and to investigate its contribution to TSCC cell growth, apoptosis, and tumorigenesis...
  4. ncbi Metastasis of squamous cell carcinoma of the oral tongue
    Daisuke Sano
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Unit 441, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Cancer Metastasis Rev 26:645-62. 2007
    ..Here we summarize the current status of investigations of SCCOT metastases and the potential of these studies to have a positive impact on the clinical management of SCCOT in the future...
  5. ncbi Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice
    Xiao Han Tang
    Departments of Pharmacology and Pathology, Weill Medical College of Cornell University, New York, New York
    Clin Cancer Res 10:301-13. 2004
    ..We have developed a mouse model using the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in the drinking water to induce tumorigenesis in the mouse oral cavity...
  6. pmc A novel organotypic model mimics the tumor microenvironment
    Sini Nurmenniemi
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
    Am J Pathol 175:1281-91. 2009
    ..Thus, the myoma model provides a promising tool for analyzing the behavior of carcinoma cells...
  7. ncbi Squamous cell carcinoma of the oropharynx: surgery, radiation therapy, or both
    James T Parsons
    Department of Radiation Oncology, Bethesda Memorial Hospital, Boynton Beach, Florida, USA
    Cancer 94:2967-80. 2002
    ..No randomized trial has addressed adequately the question of whether surgery (S), radiation therapy (RT), or combined treatment is most effective...
  8. ncbi The mushroom-shaped anterolateral thigh perforator flap for subtotal tongue reconstruction
    Benedetto Longo
    Plastic Surgery Unit, Sant Andrea Hospital, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
    Plast Reconstr Surg 132:656-65. 2013
    ..The authors describe the reinnervated mushroom-shaped anterolateral thigh perforator flap for subtotal tongue reconstruction...
  9. ncbi Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production
    K Sumitani
    Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan
    J Oral Pathol Med 30:41-7. 2001
    ..These results suggest that specific inhibition of COX-2 inhibits proliferation of cancer cells expressing COX-2 mRNA via suppression of PGE2 production...
  10. ncbi The incidence of oropharyngeal cancer in Taiwan: an endemic betel quid chewing area
    Pei Shian Ho
    Graduate Institute of Dental Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Oral Pathol Med 31:213-9. 2002
    ..Oropharyngeal cancer is the one of the most common cancers in the world. The purpose of this study was to examine the trends in oropharyngeal cancer from 1979 to 1996 in Taiwan...
  11. ncbi Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer
    Stimson P Schantz
    Department of Otolaryngology, The New York Eye and Ear Infirmary, 310 E 14th St, New York, NY 10003, USA
    Arch Otolaryngol Head Neck Surg 128:268-74. 2002
    ..To examine the temporal changes in head and neck cancer in young adults in the United States...
  12. ncbi Apoptosis of SAS cells induced by sonodynamic therapy using 5-aminolevulinic acid sonosensitizer
    Wei Song
    Department of Physics and Laboratory of Sono and Photo theranostic Technologies, Harbin Institute of Technology, Harbin, Heilongjiang, PR China
    Anticancer Res 31:39-45. 2011
    ..It is desirable to kill the cancer cells via apoptosis rather than necrosis, and therefore, it is necessary to gain a better understanding of the mechanisms of treating cancer using SDT...
  13. ncbi Expression of Bcl-2 but not Bax has a prognostic significance in tongue carcinoma
    Juan Carlos de Vicente
    Servicio de Cirugia Maxilofacial, Hospital Universitario Central de Asturias, Facultad de Medicina y Odontologia, Instituto Universitario de Oncologia del Principado de Asturias IUOPA, Oviedo, Spain
    J Oral Pathol Med 35:140-5. 2006
    ..The aim of this study was to determine the spectrum of Bax and Bcl-2 expression, and to correlate these findings with clinicopathologic variables and prognosis...
  14. ncbi Efficacy of high-dose-rate interstitial brachytherapy in patients with oral tongue carcinoma
    Jose Luis Guinot
    Department of Radiation Oncology, Fundación Instituto Valenciano de Oncología IVO, Valencia, Spain
    Brachytherapy 9:227-34. 2010
    ..To evaluate the results of high-dose-rate (HDR)-interstitial brachytherapy (ISBT) in oral tongue carcinomas...
  15. ncbi COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway
    Yan Hong Wang
    Department of Head and Neck Surgery, Sun Yat sen University Cancer Center, No 651 Dongfeng East Road, Guangzhou, Guangdong, People s Republic of China
    Med Oncol 28:S360-6. 2011
    ..Our results suggested that COX-2 played essential roles in the proliferation and metastasis of tongue cancer, and COX-2 could serve as a potential chemotherapy target for tongue cancer...
  16. ncbi Sox2 nuclear expression is closely associated with poor prognosis in patients with histologically node-negative oral tongue squamous cell carcinoma
    Lutao Du
    Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, PR China
    Oral Oncol 47:709-13. 2011
    ..According to our results, Sox2 positive expression was frequent in pN0 OTSCC and involved in tumor progression. The measurement of Sox2 expression may be helpful in predicting relapse and prognosis of patients with pN0 OTSCC...
  17. ncbi Tumor-host histopathologic variables, stromal myofibroblasts and risk score, are significantly associated with recurrent disease in tongue cancer
    Marilena Vered
    Institute of Pathology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Cancer Sci 101:274-80. 2010
    ..Therefore, the treatment concept should be adjusted accordingly and target concomitantly the epithelial malignancy and its allied stroma...
  18. ncbi Prognostic evaluation of oral tongue cancer: means, markers and perspectives (I)
    Ibrahim O Bello
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
    Oral Oncol 46:630-5. 2010
    ..In this first part, we discuss the relative merits of the methods used in prognostic studies and the clinicopathologic prognostic factors...
  19. ncbi Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue
    R J Bova
    Cancer Research Program, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales, Australia
    Clin Cancer Res 5:2810-9. 1999
    ..Simultaneous assessment of cyclin D1 and p16INK4A protein levels define subgroups of patients at increased risk of relapse and may be of clinical utility in optimizing therapy...
  20. ncbi The role of human papillomavirus in the increased incidence of base of tongue cancer
    Per Attner
    Department of Oto Rhino Laryngology, Head and Neck Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Int J Cancer 126:2879-84. 2010
    ..The incidence of base of tongue cancer, as well as the proportion of HPV-positive tumors, has increased in Sweden during the study period, suggesting that HPV may contribute to this increase...
  21. ncbi Tumour thickness predicts cervical nodal metastases and survival in early oral tongue cancer
    P O-charoenrat
    Division of Head and Neck Surgery, Department of Surgery, Siriraj Hospital Medical School, Bangkok, 10700, Thailand
    Oral Oncol 39:386-90. 2003
    ..Thus, elective neck treatment (surgery or irradiation) is indicated for tumours exceeding 5 mm thickness...
  22. ncbi Neck treatment of patients with early stage oral tongue cancer: comparison between observation, supraomohyoid dissection, and extended dissection
    Shiang Fu Huang
    Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan
    Cancer 112:1066-75. 2008
    ..The role of elective and therapeutic selective neck dissection in patients with early stage cancer of the oral tongue remains controversial. The purpose was to investigate the role of neck treatment in the management of this condition...
  23. pmc Human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy
    A M Hong
    Department of Radiation Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Building 27, Missenden Road, Camperdown, Sydney, New South Wales 2050, Australia
    Br J Cancer 103:1510-7. 2010
    ..This study examines the prognostic significance of human papillomavirus (HPV) in patients with locally advanced oropharyngeal squamous cell carcinoma (SCC) treated primarily with surgery or definitive radiotherapy...
  24. pmc Abnormal expression of bcl-2 and bax in rat tongue mucosa during the development of squamous cell carcinoma induced by 4-nitroquinoline 1-oxide
    Daniel A Ribeiro
    Department of Pathology, Center for Genotoxins and Carcinogens Evaluation, TOXICAN, Botucatu Medical School, UNESP, SP, Brazil
    Int J Exp Pathol 86:375-81. 2005
    ..Bcl-2 and bax expression appears to be associated with a risk factor in the progression of oral cancer...
  25. ncbi High dose rate versus low dose rate brachytherapy in the treatment of tongue carcinoma - a radiobiological study
    J Petera
    Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Czech Republic
    Neoplasma 56:163-8. 2009
    ..All differences were statistically highly significant. Our radiobiological study supported the hypothesis that HDR has a higher risk of complication in comparison with LDR brachytherapy for the same tumor control probability...
  26. pmc Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue
    V Häyry
    Department of Otolaryngology and Head and Neck Surgery, Helsinki University Central Hospital, Haartmaninkatu 4E, Helsinki, Finland
    Br J Cancer 102:892-7. 2010
    ..The expression of these markers has been connected to prognosis in many cancer types...
  27. ncbi Focal adhesion kinase serves as a marker of cervical lymph node metastasis and is a potential therapeutic target in tongue cancer
    Hongbing Jiang
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Nanjing Medical University, Nanjing, 210029, Jiangsu, People s Republic of China
    J Cancer Res Clin Oncol 136:1295-302. 2010
    ....
  28. ncbi Significance of galectins-1, -3, -4 and -7 in the progression of squamous cell carcinoma of the tongue
    Pollianna M Alves
    Dentistry Department, State s University of Paraíba, Campina Grande, PB, Brazil
    Pathol Res Pract 207:236-40. 2011
    ....
  29. ncbi Schwannoma of the tongue in a child
    Cigdem Tepe Karaca
    Department of Otolaryngology Head and Neck Surgery, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
    Am J Otolaryngol 31:46-8. 2010
    ..Diagnosis was confirmed by excisional biopsy. Histologic identification of Antoni A and B areas along with strong and diffuse staining with S-100 stain pathologically completed the diagnosis of schwannoma...
  30. ncbi Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell carcinoma
    Danielle Resende Camisasca
    Pathology Graduate Program, Fluminense Federal University UFF, RJ, Brazil
    Oral Oncol 45:225-33. 2009
    ..Lymphocytic infiltrate was the most meaningful histopathologic parameter in survival analysis, whereas expression of Bcl-2 family members seems to be an important marker of a favorable prognosis in OSCC...
  31. ncbi High dose rate brachytherapy for early stage oral tongue cancer
    To Wai Leung
    Department of Clinical Oncology, Tuen Mun Hospital, Hong Kong, China
    Head Neck 24:274-81. 2002
    ..High dose rate (HDR) interstitial brachytherapy of the oral tongue is a new treatment modality. Our study evaluates the outcomes of patients with early stage oral tongue cancer as treated by HDR interstitial implant...
  32. pmc Schwannoma of the tongue: two case reports and review of the literature
    Marc Cohen
    Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Eur Arch Otorhinolaryngol 266:1823-9. 2009
    ..Transoral resection allows for removal of this tumor in a manner that precludes recurrence, avoids causing morbidity of tongue function, and remains the standard approach for the treatment of the vast majority of these tumors...
  33. pmc Molecular crosstalk between cancer cells and tumor microenvironment components suggests potential targets for new therapeutic approaches in mobile tongue cancer
    Dan Dayan
    Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    Cancer Med 1:128-40. 2012
    ..Collectively, these results highlighted the emerging need of new therapies targeting this crosstalk between the cancer cells and TME components in MT cancer...
  34. ncbi The importance of stromal inflammation in squamous cell carcinoma of the tongue
    Lotta Lundqvist
    Department of Medical Biosciences Pathology, Umea University, Umea, Sweden
    J Oral Pathol Med 41:379-83. 2012
    ..SCCHN is a heterogeneous group of tumours including tumours located in the oral cavity, of which the majority is located in the tongue...
  35. ncbi Prognostic evaluation of oral tongue cancer: means, markers and perspectives (II)
    Ibrahim O Bello
    Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland
    Oral Oncol 46:636-43. 2010
    ..We conclude with future direction of prognostic studies of OTSCC...
  36. ncbi Metabolic tumor volumes by [18F]-fluorodeoxyglucose PET/CT correlate with occult metastasis in oral squamous cell carcinoma of the tongue
    Man Ki Chung
    Department of Otorhinolaryngology Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Ann Surg Oncol 16:3111-7. 2009
    ....
  37. ncbi Bcl-2 expression in oral squamous cell carcinoma
    B Popovic
    Institute of Biology and Human Genetics, School of Dentistry, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia and Montenegro
    Ann N Y Acad Sci 1095:19-25. 2007
    ..21, lip-floor of the mouth, P = 0.50) there was no significant difference. However, our results suggest that the level of bcl-2 expression could be a valuable predictor of tumor behavior and disease outcome...
  38. ncbi Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: need for a randomized controlled trial
    Anil K D'Cruz
    Division of Head Neck Surgery, Tata Memorial Hospital, Mumbai, India
    Head Neck 31:618-24. 2009
    ..The aim of this study is to determine the need for a randomized controlled trial in order to define the role of an elective neck dissection (END) in the treatment of early tongue cancers...
  39. ncbi Combined-modality treatment for advanced oral tongue squamous cell carcinoma
    Kang Hsing Fan
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taiwan
    Int J Radiat Oncol Biol Phys 67:453-61. 2007
    ..The aim of this study was to investigate prognostic factors in advanced-stage oral tongue cancer treated with postoperative adjuvant therapy and to identify indications for adjuvant concomitant chemoradiotherapy (CCRT)...
  40. ncbi Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20-44 years
    Caroline H Shiboski
    Department of Stomatology, Division of Oral Pathology, Oral Medicine, Oral Radiology, School of Dentistry, University of California San Francisco, San Francisco, California 94143 0422
    Cancer 103:1843-9. 2005
    ..The objective of the current study was to explore the trends in both oral cavity and pharyngeal squamous cell carcinoma (SCC) in younger U.S. populations, in particular tongue and tonsillar SCC...
  41. ncbi Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma
    Kyle Rusthoven
    Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado 80045 0508, USA
    Cancer 112:345-51. 2008
    ..The objective of this study was to compare survival in patients with squamous cell carcinoma (SCC) of the oral tongue with that in patients with SCC in other oral cavity subsites...
  42. ncbi Transoral robotic surgery (TORS) for base of tongue neoplasms
    BERT W O'MALLEY
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Laryngoscope 116:1465-72. 2006
    To develop a minimally invasive surgical technique for the treatment of base of tongue neoplasms using the optical and technical advantages of robotic surgical instrumentation.
  43. ncbi Phase III trial of high- vs. low-dose-rate interstitial radiotherapy for early mobile tongue cancer
    T Inoue
    Division of Multidisciplinary Radiotherapy, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Int J Radiat Oncol Biol Phys 51:171-5. 2001
    ..CONCLUSION: Hyperfractionated HDR-ISRT for early mobile tongue cancer has the same local control compared with continuous LDR-ISRT. Hyperfractionated HDR-ISRT is an alternative treatment for continuous LDR-ISRT...
  44. ncbi Results of low- and high-dose-rate interstitial brachytherapy for T3 mobile tongue cancer
    Naoya Kakimoto
    Department of Oral and Maxillofacial Radiology, Division of Oral Developmental Biology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Radiother Oncol 68:123-8. 2003
    ..To evaluate the treatment results of low-dose-rate (LDR) and high-dose-rate (HDR) interstitial brachytherapy (ISBT) for T3 mobile tongue cancer...
  45. ncbi Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma
    Morio Kusayama
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Osaka, Japan
    Cancer Sci 102:1128-36. 2011
    ..These results imply a potentially important and novel role for the inhibition of AQP3 function via the use of specific siRNA in the treatment of SCC...
  46. ncbi Immunoexpression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the metastasis of squamous cell carcinoma of the human tongue
    C X Zhou
    School of Dentistry and Oral Health and Griffith Health Institute, Gold Coast Campus, Griffith University, Southport, Gold Coast, Queensland, Australia
    Aust Dent J 55:385-9. 2010
    ..This study determined the expression of MMP-2/MMP-9 in primary tongue cancer with or without cervical metastases and analysed the significance of such expression in relation to the presence or absence of metastases...
  47. ncbi Rigid confocal endoscopy for in vivo imaging of experimental oral squamous intra-epithelial lesions
    Behnaz Farahati
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Rostock, Rostock, Germany
    J Oral Pathol Med 39:318-27. 2010
    ..A rigid confocal endoscope has been developed to assess the oral squamous epithelium of mice and to determine sensitivity, specificity, and accuracy of this new technology...
  48. ncbi Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites
    Avraham Zini
    Department of Community Dentistry, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
    J Oral Pathol Med 39:299-305. 2010
    ..The subtypes and different sites of oral cancer has different etiology epidemiology and survival rate. Prevalence of the various anatomical oral sites provided potential baseline for improvement of clinical approach...
  49. ncbi Comparison of three major radioactive sources for brachytherapy used in the treatment of node negative T1-T3 oral tongue cancer: influence of age on outcome
    Hideya Yamazaki
    Department of Radiology, National Hospital Organization Osaka National Hospital, Hoenzaka 2 1 14 Chuo ku, Osaka City, Osaka 540 0006 Japan
    Anticancer Res 27:491-7. 2007
    ..To examine the efficacy of major radioactive sources used in brachytherapy and the influence of age...
  50. ncbi Oral tongue cancer in patients less than 45 years old: institutional experience and comparison with older patients
    N Siegelmann-Danieli
    Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
    J Clin Oncol 16:745-53. 1998
    ..To evaluate the demographics, differential risk profile, and treatment outcome in patients with squamous cell carcinomas (SCCs) of the oral tongue according to age at diagnosis...
  51. ncbi Correlations of bcl-2 and p53 expression with the clinicopathological features in tongue squamous cell carcinomas
    L Yao
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Oral Oncol 35:56-62. 1999
    ....
  52. pmc Prognostic factors in tongue cancer - relative importance of demographic, clinical and histopathological factors
    S Kantola
    Departments of Oral and Maxillofacial Surgery, Diagnostics and Oral Medicine, Institute of Dentistry, Oulu University Hospital, University of Oulu, Aapistie 3, Oulu, 90220, Finland
    Br J Cancer 83:614-9. 2000
    ..Such cases may require more aggressive treatment. Among patients with stage III-IV carcinomas, heavy use of alcohol was significantly associated with a poor disease-specific survival time...
  53. ncbi An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 27:619-30. 2006
    ....
  54. ncbi Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue
    J N Myers
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 92:3030-6. 2001
    ....
  55. ncbi Current status and perspectives of brachytherapy for head and neck cancer
    Hitoshi Shibuya
    Department of Radiology, Tokyo Medical and Dental University Hospital, Tokyo, Japan
    Int J Clin Oncol 14:2-6. 2009
    ..The major problems are neck node metastasis and a second primary cancer of the respiratory tract or upper digestive tract, and the minor problem is radiation-induced cancer...
  56. ncbi Genomic instability in non-neoplastic oral mucosa cells can predict risk during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
    Daniel Araki Ribeiro
    Departamento de Patologia, Núcleo de Avaliação Toxicogenética e Cancerígena, TOXICAN, Faculdade de Medicina de Botucatu, UNESP, Distrito de Rubiao Jr s n, 18618 000, SP, Brazil
    Oral Oncol 40:910-5. 2004
    ..Genomic instability appears to be associated with the risk and progression of oral cancer...
  57. ncbi Two cases of neurilemmoma of the tongue
    Kadambari Batra
    Department of Otolaryngology, Safdarjung Hospital, New Delhi, India
    Ear Nose Throat J 86:679-81. 2007
    ..We describe our management of these 2 cases, and we discuss what has been published in the literature regarding the presentation, diagnosis, histopathology, treatment, and prognosis for patients with glossal neurilemmoma...
  58. ncbi Tongue base schwannoma: report, review, and unique surgical approach
    Raja Sawhney
    Wayne State University School of Medicine, Detroit, MI 48201, USA
    Am J Otolaryngol 29:119-22. 2008
    ..Histologic identification of Antoni A and B areas along with strong and diffuse staining with S-100 stain pathologically completed the diagnosis of schwannoma...
  59. ncbi Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance
    Nobuyuki Fujii
    Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Tottori, Japan
    J Oral Pathol Med 41:444-51. 2012
    ....
  60. ncbi Schwannoma of tongue - a case report and short review of literature
    Rashmi Patnayak
    Acta Oncol 46:265-6. 2007
  61. ncbi Brachytherapy for early oral tongue cancer: low dose rate to high dose rate
    Hideya Yamazaki
    Department of Radiology, Toyonaka Municipal Hospital, Shibahara 4 14 1, Toyonaka, 560 8565 Osaka, Japan
    J Radiat Res 44:37-40. 2003
    ..HDR brachytherapy achieved the same locoregional result as did LDR brachytherapy. A converting factor of 0.86 is applicable for HDR in the treatment of early oral tongue cancer...
  62. ncbi Base of tongue neurilemmoma: excision by transoral laser microsurgery
    Ferran Ballesteros
    Department of Otolaryngology Head and Neck Surgery, University of Barcelona, Spain
    Acta Otolaryngol 127:1005-7. 2007
    ..In this case, fiberoptic examination and magnetic resonance imaging were crucial as first step studies to elucidate the biology of the lesion...
  63. ncbi Multinodular neurilemmoma of the tongue: a case report with differential immunohistochemical profile
    P R Ferreti Bonan
    Department of Oral Diagnosis, School of Dentistry, State University of Montes Claros, UNIMONTES, Montes Claros, MG, Brazil
    Minerva Stomatol 57:71-5. 2008
    ..Immunostaining was strongly positive for S-100 protein and negative for neurofilament. The lesion was excised and after 12 months of follow-up there was no recurrence...
  64. ncbi Predictive value of histopathologic parameters in early squamous cell carcinoma of oral tongue
    Harri Keski-Säntti
    Department of Otorhinolaryngology Head and Neck Surgery, Helsinki University Central Hospital, P O Box 220, FIN 00029 HUCH, Helsinki, Finland
    Oral Oncol 43:1007-13. 2007
    ..The risk for occult metastases and local recurrence was high in patients with pT2 tumours...
  65. ncbi Transoral robotic surgery using the thulium:YAG laser: a prospective study
    Kathryn M Van Abel
    Department of Otolaryngology Head and Neck Surgery, Mayo Clinic School of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Arch Otolaryngol Head Neck Surg 138:158-66. 2012
    ..To compare thulium:YAG laser-assisted transoral robotic surgery (TY:TORS) and conventional electrocautery-equipped TORS (EC:TORS) in patients undergoing transoral resection of upper aerodigestive tract malignant neoplasms...
  66. ncbi Prognostic factors for local control and survival of cancer of the oral tongue. A retrospective analysis of 230 cases in western Sweden
    J Nyman
    Department of Oncology, , Sahlgrenska Hospital, Sweden
    Acta Oncol 32:667-73. 1993
    ..Extension to the tonsillar region, extension to the floor of the mouth and level of neck nodes were significantly associated with local-regional control...
  67. ncbi Clinical application of free anterolateral thigh flap in the reconstruction of intraoral defects
    Guowen Sun
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Nanjing University Medical Center, Nanjing University, Stomatological Hospital of Nanjing, Nanjing, China
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:34-41. 2011
    ..The purpose of this study was to assess the clinical features and therapeutic efficacy of the intraoral defects reconstruction with 3 types of anterolateral thigh flaps...
  68. ncbi Atypical lipoma of the tongue
    P L Moore
    Department of Otolaryngology Head and Neck Surgery, Warwick Hospital, Warwick, UK
    J Laryngol Otol 115:859-61. 2001
    ..Atypical lipoma should be completely excised with a cuff of normal tissue in order to prevent repeated local recurrence and the possibility of de-differentiation...
  69. ncbi Prognostic factors for T1-T2 squamous cell carcinomas of the mobile tongue: A retrospective cohort study
    Laurent Bonnardot
    Department of Otorhinolaryngology Head and Neck Surgery, Hotel Dieu Hospital, University of Nantes, Nantes, France
    Head Neck 33:928-34. 2011
    ..The aim of this study was to identify factors predicting poor prognosis at the time of early oral tongue carcinoma diagnosis...
  70. ncbi Stomal metastases complicating percutaneous endoscopic gastrostomy: CT findings and the argument for radiologic tube placement
    Perry J Pickhardt
    Department of Radiology, National Naval Medical Center, 8901 Wisconsin Ave, Bethesda, MD 20889 5600, USA
    AJR Am J Roentgenol 179:735-9. 2002
    ..Cumulative data from previous case reports are also considered for insight into causes of metastasis and the implications for gastrostomy placement in these patients...
  71. pmc Brachytherapy of stage II mobile tongue carcinoma. Prediction of local control and QOL
    Sayako Oota
    Department of Radiology, Asahi General Hospital, I 1326, Asahi, Chiba, Japan
    Radiat Oncol 1:21. 2006
    ..There is no consensus as to the prognostic model for brachytherapy of tongue carcinoma. This study was designed to evaluate the prognostic factors for local control based on a large population under a unified treatment policy...
  72. ncbi Different expression patterns of pAkt, NF-κB and cyclin D1 proteins during the invasion process of head and neck squamous cell carcinoma: an in vitro approach
    Fernanda Salgueiredo Giudice
    Department of Oral Pathology, School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil
    J Oral Pathol Med 40:405-11. 2011
    ..This study sought to evaluate the expression of pAkt, NF-κB and cyclin D1 proteins in head and neck squamous cell carcinoma cell lines and their respective in vitro-obtained invasive clones...
  73. ncbi Epidemiological analysis of tongue cancer in South Australia for the 24-year period, 1977-2001
    L Lam
    Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide
    Aust Dent J 51:16-22. 2006
    ..This study aimed to determine the epidemiology and survival trends of tongue cancer in South Australia over the 24-year period from 1977 to 2001...
  74. pmc Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older
    Hideya Yamazaki
    Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566 Japan
    Radiat Oncol 5:116. 2010
    ..To examine the role of brachytherapy for aged patients 80 or more in the trend of rapidly increasing number...
  75. ncbi Tongue cancer patients have a high frequency of allelic loss at the von Hippel-Lindau gene and other loci on 3p
    Takeshi Asakawa
    Department of Otolaryngology Head and Neck Surgery, Nihon University School of Medicine, Japan
    Cancer 112:527-34. 2008
    ..In addition, the coding region of the intact VHL allele was screened for sequence mutations...
  76. ncbi Trends in the epidemiology of oral squamous cell carcinoma in Western UP: an institutional study
    Preeti Sharma
    Department of Oral Pathology and Microbiology, Subharti Dental College, Meerut UP, India
    Indian J Dent Res 21:316-9. 2010
    ..The purpose of the study was to identify trends in incidence rates of oral squamous cell carcinoma (OSCC) at specific anatomic sites or within specific age or sex groups in the Western Uttar Pradesh population...
  77. ncbi High-dose rate interstitial brachytherapy for stage I-II tongue cancer
    M Umeda
    Department of Oral and Maxillofacial Surgery, Kobe University School of Medicine, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90:667-70. 2000
    ..This retrospective clinical study evaluated the usefulness of high-dose rate (HDR) brachytherapy for stage I-II tongue cancer in comparison with traditional low-dose rate (LDR) brachytherapy...
  78. ncbi [Treatment and prognostic analysis of 92 cases with advanced mobile tongue squamous cell carcinoma]
    Chuan Zheng Sun
    Departmemt of Head and Neck Surgery, The Third Affiliated Hospital of Kunming Medical College, Kunming 650118, China
    Zhonghua Kou Qiang Yi Xue Za Zhi 41:650-3. 2006
    ..To compare the results of different treatment modalities for the advanced tongue squamous cell carcinoma and investigate the factors that influence its prognosis...
  79. pmc Transcriptomic dissection of tongue squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    BMC Genomics 9:69. 2008
    ..It is significantly more aggressive than other forms of HNOSCC, in terms of local invasion and spread. In this study, we aim to identify specific transcriptomic signatures that associated with OTSCC...
  80. ncbi Survival time and prognostic factors of oral cancer in Ubon Ratchathani Cancer Center
    Watcharin Kruaysawat
    Srimuangmai Hospital, Ubon Ratchathani, Thailand
    J Med Assoc Thai 93:278-84. 2010
    ..To characterize the survival time and prognostic factors of oral cancer in Ubon Ratchathani, Thailand...
  81. ncbi Squamous cell carcinoma of the oral tongue in patients younger than 30 years: clinicopathologic features and outcome
    E Soudry
    Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tiqwa, Israel
    Clin Otolaryngol 35:307-12. 2010
    ..To assess the possible effect of young age on clinical behaviour and survival outcome of squamous cell carcinoma of the oral tongue...
  82. ncbi Survey of risk factors contributed to lymphatic metastasis in patients with oral tongue cancer by immunohistochemistry
    Zhuang Zhang
    State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
    J Oral Pathol Med 40:127-34. 2011
    ..Here, we investigated the expression levels of seven biomarkers in oral squamous cell carcinoma (OSCC) tissues as well as their associations with the clinicopathologic features of OTSCC patients...
  83. ncbi Microarray gene expression profiling of cell lines from primary and metastatic tongue squamous cell carcinoma: possible insights from emerging technology
    Nadarajah Vigneswaran
    Department of Diagnostic Sciences, University of Texas Houston Dental Branch, Houston, TX, USA
    J Oral Pathol Med 34:77-86. 2005
    ..To identify common gene expression patterns among two uniquely matched pairs of primary and metastatic oral squamous cell carcinoma (OSCC) cell lines derived from the same two patient donors...
  84. ncbi Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats
    Hiroyuki Tsuda
    Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Food Chem Toxicol 45:1013-9. 2007
    ..Tongue SCC induction of wild males and all females was not significant. The present results suggest that DAG oil may have enhancing and/or promotion potential for tongue carcinogenesis in male Tg featuring elevated ras expression...
  85. pmc Muscle invasion in oral tongue squamous cell carcinoma as a predictor of nodal status and local recurrence: just as effective as depth of invasion?
    Katherine Chandler
    Department of Pathology and Laboratory Medicine, Emory University, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
    Head Neck Pathol 5:359-63. 2011
    ..Interestingly, the PPV of local recurrence was higher with muscle invasion than DOI, and may represent an important indicator for extent of resection...
  86. ncbi Squamous cell carcinoma of tongue in a 19-year-old female
    T Randhawa
    Department of Oral Pathology and Microbiology, Government Dental College, Calicut 673 008, Kerala, India
    Indian J Cancer 45:128-30. 2008
    ..This report focuses on the etiological factors and prognosis related to the case. Additionally, a brief literature review regarding squamous cell carcinoma in young patients is also included...
  87. ncbi Scutellarin inhibits cell migration by regulating production of αvβ6 integrin and E-cadherin in human tongue cancer cells
    Haixia Li
    Department of Anatomy, Basic Medical Science College, the Second Clinical College, Harbin Medical University, Harbin 150081, PR China
    Oncol Rep 24:1153-60. 2010
    ..This study shows that scutellarin inhibits tumor cell proliferation and migration and regulates cell adhesion in OSCC cells; this may be closely related to up-regulation of E-cadherin and down-regulation of αvβ6 integrin...
  88. ncbi Prognostic importance of site in squamous cell carcinoma of the buccal mucosa
    R J Shaw
    Department of Surgery and Oncology, University of Liverpool, Liverpool, UK
    Br J Oral Maxillofac Surg 47:356-9. 2009
    ..34). We conclude that site had little influence on prognosis, and that the poor outcome of buccal cancers reported from other centres has not been replicated in our series...
  89. ncbi Carcinoma of tongue and the buccal mucosa represent different biological subentities of the oral carcinoma
    K M Sathyan
    Laboratory of Cell Cycle Regulation and Molecular Oncology, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, 695 011, India
    J Cancer Res Clin Oncol 132:601-9. 2006
    ..However, studies identifying the reason for such difference are lacking in the literature...
  90. ncbi Elective management of the clinically negative neck by otolaryngologists in patients with oral tongue cancer
    John W Werning
    Department of Otolaryngology, University of Florida, 1600 SW Archer Rd, Room M 228, Gainesville, FL 32610 0264, USA
    Arch Otolaryngol Head Neck Surg 129:83-8. 2003
    ..Furthermore, the treatment delivered to patients with a cN0 neck by practicing otolaryngologists is not known...
  91. ncbi Dysphagia secondary to head and neck cancer surgery
    F M McConnel
    Emory University Medical School, Atlanta, Georgia
    Acta Otorhinolaryngol Belg 48:165-70. 1994
    ..Recommendations are made for the most functional types of reconstruction based upon the experience of the senior author...
  92. ncbi Role of myeloid cell leukemia-1 in cell growth of squamous cell carcinoma
    Masahide Nagata
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Japan
    J Pharmacol Sci 110:344-53. 2009
    ..These results imply a potentially important and novel role of the inhibition of Mcl-1 function by the use of specific siRNA in the treatment of SCC...
  93. ncbi Well-differentiated liposarcoma of the tongue
    F D Nunes
    Disciplina de Patologia Bucal, Faculdade de Odontologia, Universidade de Sao Paulo, Av Prof Lineu Prestes, 2227, Butanta, CEP 05508 900, Brazil
    Oral Oncol 38:117-9. 2002
    ..Lipoma, spindle-cell lipoma, myxoma, hibernoma, angiolipoma, fibrolipoma, pseudosarcomatous faciitis and malignant hysticytoma were considered in the diagnosis process. The patient was treated surgically and so far is free of disease...
  94. ncbi Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats
    Louise Y Y Fong
    Kimmel Cancer Center, Thomas Jefferson University, 1020 Locust St, Philadelphia, PA 19107
    J Natl Cancer Inst 97:40-50. 2005
    ..Using rat models, we examined whether zinc regulates COX-2 expression in these cancers...
  95. ncbi [Squamous-cell carcinoma of the tongue: treatment results and prognosis]
    N Zwetyenga
    Service de Chirurgie Maxillo faciale, Centre Hospitalier Universitaire, Hopital Pellegrin, 33076 Bordeaux Cedex
    Rev Stomatol Chir Maxillofac 104:10-7. 2003
    ..The aim of the study was to assess the results of curative treatment of patients with squamous cell carcinoma of the tongue and to evaluate survival and predictive factors of recurrence...
  96. ncbi Prediction of delayed neck metastasis in patients with stage I/II squamous cell carcinoma of the tongue
    Masumi Okamoto
    Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan
    J Oral Pathol Med 31:227-33. 2002
    ..The aim of this study was to evaluate the clinicopathological and immunohistochemical parameters associated with DNM in patients with stage I/II SCC...
  97. pmc Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2
    Louise Y Y Fong
    Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Int J Cancer 122:978-89. 2008
    ..Thus, targeting only the COX-2 pathway in zinc-deficient animals did not prevent UADT carcinogenesis. Our data suggest zinc supplementation should be more thoroughly explored in human prevention clinical trials for UADT cancer...
  98. ncbi Expression of cyclo-oxygenase-2 in human tongue carcinoma and its precursor lesions
    Jutta Renkonen
    Transplantion Laboratory, Haarman Institute and Helsinki University Central Hospital, P O Box 21, Haarmaninkatu 3, 00014 Helsinki, Finland
    Virchows Arch 440:594-7. 2002
    ..The presence of Cox-2 in squamous cell carcinomas of the oral mucosa and its precursor lesions indicate that Cox-2 could participate in the carcinogenic process of these oral malignancies...
  99. ncbi Sentinel node mapping for node positive oral cancer: potential to predict multiple metastasis
    Takashi Matsuzuka
    Department of Otolaryngology, Fukushima Medical University School of Medicine, Fukushima, Japan
    Laryngoscope 118:646-9. 2008
    ..The objective of this study is to evaluate lymph node mapping for clinically positive neck metastasis using a sentinel node navigation technique...
  100. ncbi [Multivariate analysis of prognosis of patients with clinical stage I and II carcinoma of mobile tongue]
    Hui Hua
    Department of Head and Neck Surgery, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, 510060, PR China
    Ai Zheng 22:210-3. 2003
    ..There are many factors affecting the prognosis of the patients with clinical stage I and II carcinoma of mobile tongue. This study was designed to analyze the most important factors affecting the prognosis...
  101. pmc Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer
    J T Korpi
    Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Oulu and Oulu University Hospital, Oulu, Finland
    Br J Cancer 98:766-75. 2008
    ..According to these data, we propose that, contrary to the role of most proteases produced by human carcinomas, MMP-8 has a protective, probably oestrogen-related role in the growth of mobile tongue SCCs...

Research Grants25

  1. Origins of Spontaneous Mutagenesis
    Joseph Guttenplan; Fiscal Year: 2005
    ..abstract_text> ..
  2. HPV Oral-Pharyngeal Study
    Laura A Koutsky; Fiscal Year: 2010
    ..The proposed cohort study of young men will provide new scientific knowledge that is essential for developing preventative strategies to reduce the global burden of HPV-related cancer of the tongue, throat, and tonsils. ..
  3. Fiber Optic In Vivo Confocal Microscopy
    Rebecca Richards Kortum; Fiscal Year: 2005
    ..The fifth aim of this proposal is to design and construct inexpensive, injection-modeled optical elements that can be easily integrated with the inexpensive fiber optic imaging bundles used in current prototypes. ..
  4. Fiber Optic In Vivo Confocal Microscopy
    Rebecca Richards Kortum; Fiscal Year: 2002
    ..The fifth aim of this proposal is to design and construct inexpensive, injection-modeled optical elements that can be easily integrated with the inexpensive fiber optic imaging bundles used in current prototypes. ..
  5. The 7th International Conference on Head and Neck Cancer
    Jeffrey Myers; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. HYPOXIC IMAGING GUIDED INTENSITY MODULATED RADIOTHERAPY
    KS CLIFFORD CHAO; Fiscal Year: 2003
    ..They will test the hypothesis by performing multiple Cu-60 ATSM PET scans during the course of irradiation to understand the spatial evolution of hypoxic tumor. ..
  7. Early Prediction of Pathological Response of Chemoradiotherapy with FLT PET
    KS CLIFFORD CHAO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2004
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  9. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
    ..abstract_text> ..
  10. Adenoviral GFP targeting of metastatic human tumors using multiple delivery route
    Hiroyuki Kishimoto; Fiscal Year: 2008
    ..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
  11. Orthotopic models of tumor angiogenesis and blood flow
    Meng Yang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Use of Serum HPV16 DNA as a Marker for Oropharyngeal Cancer Recurrence
    Erich Sturgis; Fiscal Year: 2008
    ..abstract_text> ..
  13. Multiattribute decision theory for IMRT plan selection
    Mark Phillips; Fiscal Year: 2009
    ..We will develop and evaluate influence diagrams for prostate cancer and for head &neck cancer. ..
  14. Oxidative Stress, DNA Repair & Colorectal Adenoma Risk
    Michael Goodman; Fiscal Year: 2009
    ..The resulting data will be analyzed using multivariate unconditional logistic regression models. Particular attention will be paid to identification of potential gene- gene, gene-lifestyle, and gene-phenotype interactions. ..
  15. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
  16. Mutagenicity of tobacco smoke in human cell co-cultures
    Joseph Guttenplan; Fiscal Year: 2007
    ..Clearly, it is preferable to determine their potential risk prospectively, rather than retrospectively. [unreadable] [unreadable] [unreadable]..
  17. Periodontal Disease and the Incidence of Oral Cancer
    Mine Tezal; Fiscal Year: 2007
    ..Prevention of oral cancer could begin with prevention and early treatment of periodontitis. [unreadable] [unreadable] [unreadable]..
  18. RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 2002
    ..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  19. Rheumatoid Arthritis: Predictors of Therapeutic Response
    JAMES O DELL; Fiscal Year: 2002
    ..Retrospective analysis of this information can be utilized to plan prospective clinical trials using potentially predictive patterns of cytokine, matrix metalloproteinases, and genetic factors. ..
  20. Discovery of novel fluorescent reporter genes
    Ming Zhao; Fiscal Year: 2004
    ..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
  21. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    ..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
  22. Imageable tumor-targeting bacteria
    Ming Zhao; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  23. Targeted tumoricidal bacteria
    Ming Zhao; Fiscal Year: 2007
    ..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
  24. Dual-color tumor-host imaging models
    Meng Yang; Fiscal Year: 2007
    ..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
  25. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..