mouth neoplasms

Summary

Summary: Tumors or cancer of the MOUTH.

Top Publications

  1. ncbi Profiling early head and neck cancer
    Keith D Hunter
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland
    Nat Rev Cancer 5:127-35. 2005
  2. ncbi Global epidemiology of oral and oropharyngeal cancer
    Saman Warnakulasuriya
    Department of Oral Medicine and Experimental Oral Pathology, King s College Dental Institute, Bessemer Road, London SE5 9RS, UK
    Oral Oncol 45:309-16. 2009
  3. ncbi Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer
    Ken ichi Kozaki
    Department of Genome Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Res 68:2094-105. 2008
  4. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
  5. ncbi Nomenclature and classification of potentially malignant disorders of the oral mucosa
    S Warnakulasuriya
    Department of Oral Medicine, King s College London Dental Institute at Guy s, Denmark Hill Campus, Caldecot Road, London, UK
    J Oral Pathol Med 36:575-80. 2007
  6. ncbi Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy
    S Choi
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 441, corrected Houston, TX 77030 4009, USA
    J Dent Res 87:14-32. 2008
  7. ncbi Lifestyle risk factors for oral cancer
    Stefano Petti
    Department of Public Health Sciences G Sanarelli, Sapienza University, P le Aldo Moro 5, 00185 Rome, Italy
    Oral Oncol 45:340-50. 2009
  8. ncbi Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States
    Anil K Chaturvedi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Clin Oncol 26:612-9. 2008
  9. pmc Current concepts in management of oral cancer--surgery
    Jatin P Shah
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Oral Oncol 45:394-401. 2009
  10. pmc A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma
    Chien Hua Peng
    Resource Center for Clinical Research, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, Republic of China
    PLoS ONE 6:e23452. 2011

Detail Information

Publications355 found, 100 shown here

  1. ncbi Profiling early head and neck cancer
    Keith D Hunter
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland
    Nat Rev Cancer 5:127-35. 2005
    ..Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy...
  2. ncbi Global epidemiology of oral and oropharyngeal cancer
    Saman Warnakulasuriya
    Department of Oral Medicine and Experimental Oral Pathology, King s College Dental Institute, Bessemer Road, London SE5 9RS, UK
    Oral Oncol 45:309-16. 2009
    ....
  3. ncbi Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer
    Ken ichi Kozaki
    Department of Genome Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Res 68:2094-105. 2008
    ..Taken together, our results clearly show that miR-137 and miR-193a are tumor suppressor miRNAs epigenetically silenced during oral carcinogenesis...
  4. ncbi Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    Aimee R Kreimer
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:467-75. 2005
    ..Small sample size and publication bias complicate the assessment of the prevalence of HPV in head and neck sites beyond the oropharynx...
  5. ncbi Nomenclature and classification of potentially malignant disorders of the oral mucosa
    S Warnakulasuriya
    Department of Oral Medicine, King s College London Dental Institute at Guy s, Denmark Hill Campus, Caldecot Road, London, UK
    J Oral Pathol Med 36:575-80. 2007
    ..The terminology presented in this report reflects our best understanding of multi-step carcinogenesis in the oral mucosa, and aspires to engender consistency in use...
  6. ncbi Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy
    S Choi
    Department of Head and Neck Surgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 441, corrected Houston, TX 77030 4009, USA
    J Dent Res 87:14-32. 2008
    ....
  7. ncbi Lifestyle risk factors for oral cancer
    Stefano Petti
    Department of Public Health Sciences G Sanarelli, Sapienza University, P le Aldo Moro 5, 00185 Rome, Italy
    Oral Oncol 45:340-50. 2009
    ....
  8. ncbi Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States
    Anil K Chaturvedi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Clin Oncol 26:612-9. 2008
    ....
  9. pmc Current concepts in management of oral cancer--surgery
    Jatin P Shah
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Oral Oncol 45:394-401. 2009
    ....
  10. pmc A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma
    Chien Hua Peng
    Resource Center for Clinical Research, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan, Republic of China
    PLoS ONE 6:e23452. 2011
    ..This study identified a candidate molecular signature associated with poor prognosis in OSCC patients, which may ultimately facilitate patient-tailored selection of therapeutic strategies...
  11. ncbi Genome-wide profiling of oral squamous cell carcinoma
    Yann Jang Chen
    Department of Life Science, National Yang Ming University, Taipei, Taiwan
    J Pathol 204:326-32. 2004
    ..These data demonstrate that genomic profiling can be useful in analysing pathogenetic events involved in the genesis or progression of OSCC...
  12. ncbi Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators
    Mousumi Majumder
    Human Genetics Unit, Biological Sciences Division, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India
    Int J Cancer 120:2148-56. 2007
    ..4, respectively) among slow acetylators. Although none of the 3 loci could modulate the risk of the diseases independently but 2 loci in combination, working in 2 different biochemical pathways, could do so in these patient populations...
  13. ncbi Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement
    S Warnakulasuriya
    Department of Oral Medicine, King s College Dental Institute at Guy s, King s and St Thomas Hospitals, London, UK
    J Oral Pathol Med 37:127-33. 2008
    ....
  14. ncbi Oral cancer: clinical features
    Jose Bagan
    Valencia University, Department of Stomatology, University General Hospital, Valencia, Spain
    Oral Oncol 46:414-7. 2010
    ..The different diagnosis should be established with other oral malignant diseases such as lymphomas, sarcomas and metastasis, which have rapid growth rates as opposed to the typical OSCC...
  15. ncbi Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
    Yin Ju Chen
    Graduate Institute of Biomedical Science, Chang Gung University, 259 Wen hwa 1 Road, Taoyuan 333, Taiwan
    Cancer Sci 99:1507-14. 2008
    ..Knowledge of molecular carcinogenesis of HNC may provide critical clues for diagnosis, prognosis, individualization of therapy and molecular therapeutics...
  16. ncbi Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma
    Anak Iamaroon
    Department of Odontology and Oral Pathology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand 50200
    J Oral Pathol Med 32:195-9. 2003
    ..Although mast cells (MCs) have been implicated in promoting angiogenesis in some malignant tumors, especially of the aerodigestive tract, little is known in oral squamous cell carcinoma (SCC)...
  17. ncbi Increase of microRNA miR-31 level in plasma could be a potential marker of oral cancer
    C J Liu
    Institute of Oral Biology, School of Dentistry, National Yang Ming University, Taipei, Taiwan
    Oral Dis 16:360-4. 2010
    ..miR-31 was found markedly up-regulated in OSCC and several other malignancies. However, miR-31 expression was also down-regulated in the metastasis process of breast carcinoma...
  18. ncbi Oral cancer prevention and control--the approach of the World Health Organization
    Poul Erik Petersen
    Global Oral Health Programme, World Health Organization, 20 Avenue Appia, CH1211 Geneva 27, Switzerland
    Oral Oncol 45:454-60. 2009
    ..who.int/oral_health...
  19. ncbi Oral squamous cell carcinoma: review of prognostic and predictive factors
    João Massano
    Faculty of Medicine, University of Coimbra, Coimbra University Hospital, Coimbra, Portugal
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:67-76. 2006
    ....
  20. ncbi Descriptive epidemiology of upper aerodigestive tract cancers in France: incidence over 1980-2005 and projection to 2010
    Karine Ligier
    Registre général des cancers de Lille et de sa région, F 59120 Loos, France
    Oral Oncol 47:302-7. 2011
    ..This urges actions towards reducing the major risk factors for those cancers, namely alcohol and tobacco consumption, especially among young people, and reducing exposure to risk factors due to social inequalities...
  21. pmc Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices
    Pawadee Lohavanichbutr
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Mail Stop M5 C800, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Arch Otolaryngol Head Neck Surg 135:180-8. 2009
    ..To study the difference in gene expression between human papillomavirus (HPV)-positive and HPV-negative oral cavity and oropharyngeal squamous cell carcinoma (OSCC)...
  22. ncbi Impact of RECK gene polymorphisms and environmental factors on oral cancer susceptibility and clinicopathologic characteristics in Taiwan
    Tsung Te Chung
    Institute of Medicine, Chung Shan Medical University, No 110, Section 1, Chien Kuo North Road, Taichung 402, Taiwan
    Carcinogenesis 32:1063-8. 2011
    ..These results support that gene-environment interactions between the RECK polymorphisms, smoking and betel quid may alter oral cancer susceptibility and metastasis...
  23. pmc Tumor cell and carcinoma-associated fibroblast interaction regulates matrix metalloproteinases and their inhibitors in oral squamous cell carcinoma
    Alexandra Fullár
    1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi ut 26, 1085 Budapest, Hungary
    Exp Cell Res 318:1517-27. 2012
    ..The crosstalk between cancer- and the surrounding fibroblast stromal-cells is essential for the fine tuning of cancer cells invasivity...
  24. ncbi Expression and clinical significance of matrix metalloproteinase-2 and matrix metalloproteinase-9 in oral squamous cell carcinoma
    Juan Carlos de Vicente
    Department of Oral and Maxillofacial Surgery, University Hospital of Oviedo, Oviedo, Spain
    Oral Oncol 41:283-93. 2005
    ..Ethanol could enhance the carcinogenetic process in oral cavity through its influence in the expression of MMP-2 and -9...
  25. ncbi Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome
    Lai Kui Liu
    Department of Oral Pathology, College of Stomatology, Nanjing Medical University, Jiangsu 210029, China
    Mod Pathol 23:213-24. 2010
    ..The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma...
  26. ncbi Stromal features are predictive of disease mortality in oral cancer patients
    Daniel Marsh
    Centre for Tumour Biology, Bart s and The London School of Medicine and Dentistry, London, UK
    J Pathol 223:470-81. 2011
    ..Whether used independently or as part of a prognostic model, SMA identifies a significant group of patients with aggressive tumours, regardless of disease stage...
  27. ncbi The epigenetics of oral cancer
    R Shaw
    Regional Maxillofacial Unit, University Hospital Aintree, Liverpool, UK
    Int J Oral Maxillofac Surg 35:101-8. 2006
    ..In addition, current trials are evaluating the safety and efficacy of agents affecting epigenetic changes in cancer patients which hold some therapeutic promise...
  28. ncbi A subpopulation of CD133(+) cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy
    Qunzhou Zhang
    Center for Craniofacial Molecular Biology, University of Southern California, School of Dentistry, Los Angeles, CA 90033, USA
    Cancer Lett 289:151-60. 2010
    ..Our data suggest that CD133(+) cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC...
  29. pmc Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations
    Brian B Tuch
    Life Technologies Inc, Foster City, California, United States of America
    PLoS ONE 5:e9317. 2010
    ..These results support a model in which allele-specific deletions and duplications drive allele-specific changes in gene expression in the developing tumor...
  30. ncbi Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity: a meta-analysis of reported studies
    Shao Hui Huang
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 115:1489-97. 2009
    ..To address this question, the authors conducted a meta-analysis...
  31. ncbi Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases
    Daisuke Uchida
    Department of Oral Surgery, Subdivision of Molecular Oral Medicine, Division of Integrated Sciences of Translational Research, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima, Japan
    Eur J Cancer 47:452-9. 2011
    ..These results suggest that blockade of CXCR4 may be a potent anti-metastatic therapy against lymph node metastases in cases of CXCR4-related OSCC...
  32. ncbi High stromal carbonic anhydrase IX expression is associated with nodal metastasis and decreased survival in patients with surgically-treated oral cavity squamous cell carcinoma
    Nigel T Brockton
    Division of Preventive Oncology, Department of Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Oral Oncol 48:615-22. 2012
    ..Assessment of stromal CAIX expression could identify patients with the least favorable prognosis and inform therapeutic strategies in OCSCC...
  33. ncbi Over-expression of integrin-linked kinase correlates with aberrant expression of Snail, E-cadherin and N-cadherin in oral squamous cell carcinoma: implications in tumor progression and metastasis
    Dan Zhao
    Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, China
    Clin Exp Metastasis 29:957-69. 2012
    ..ILK should be considered as a critical prognostic indicator for patients with OSCC...
  34. ncbi Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management
    Isaac van der Waal
    VU University Medical Center Academic Centre for Dentistry Amsterdam, Department of Oral and Maxillofacial Surgery Pathology, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Oral Oncol 45:317-23. 2009
    ..Finally, brief attention has been paid to oral submucous fibrosis, actinic cheilitis, some inherited cancer syndromes and immunodeficiency in relation to cancer predisposition...
  35. ncbi Intercountry prevalences and practices of betel-quid use in south, southeast and eastern Asia regions and associated oral preneoplastic disorders: an international collaborative study by Asian betel-quid consortium of south and east Asia
    Chien Hung Lee
    Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Int J Cancer 129:1741-51. 2011
    ..In conclusion, the ABC study reveals the significant cultural and demographic differences contributing to practice patterns of BQ usage and the great health risks that such practices pose in the Asian region...
  36. ncbi Evaluation of an autofluorescence based imaging system (VELscope™) in the detection of oral potentially malignant disorders and benign keratoses
    K H Awan
    Oral Medicine, Department of Clinical and Diagnostic Sciences, King s College London Dental Institute, United Kingdom
    Oral Oncol 47:274-7. 2011
    ..1% and 15.3% respectively. While VELscope was useful in confirming the presence of oral leukoplakia and erythroplakia and other oral mucosal disorders, the device was unable to discriminate high-risk from low-risk lesions...
  37. ncbi Oral cancer and precancerous lesions
    Brad W Neville
    Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, USA
    CA Cancer J Clin 52:195-215. 2002
    ..The purpose of this article is to review the clinical features of oral cancer and premalignant oral lesions, with an emphasis on early detection...
  38. ncbi Enhanced nitrosative and oxidative stress with decreased total antioxidant capacity in patients with oral precancer and oral squamous cell carcinoma
    Sheetal D Korde
    Department of Oral Pathology and Microbiology, Sharad Pawar Dental College, Wardha, India
    Oncology 80:382-9. 2011
    ..This study aims to evaluate ROS and RNS, together with the total antioxidant capacity (TAC), in serum and tissues of OSCC patients...
  39. ncbi Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas
    Michael P Rethman
    College of Dentistry, The Ohio State University, Columbus, OH, USA
    J Am Dent Assoc 141:509-20. 2010
    ..This report addresses the potential benefits and potential risks of screening for oral squamous cell carcinomas and the use of adjunctive screening aids to visualize and detect potentially malignant and malignant oral lesions...
  40. ncbi Evaluation of immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 in oral and oropharyngeal squamous cell carcinoma
    Christos Perisanidis
    Department of Cranio, Maxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria
    J Oral Pathol Med 41:40-6. 2012
    ....
  41. ncbi Impact of uPA system gene polymorphisms on the susceptibility of environmental factors to carcinogenesis and the development of clinicopathology of oral cancer
    Chia Jui Weng
    Graduate Institute of Applied Science of Living, Tainan University of Technology, Tainan, Taiwan
    Ann Surg Oncol 18:805-12. 2011
    ..However, their possible impact on the risk and prognosis of oral cancer and the susceptibility of environmental carcinogens to oral cancer remains poorly investigated...
  42. ncbi State of homeobox A10 expression as a putative prognostic marker for oral squamous cell carcinoma
    Masanobu Yamatoji
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Oncol Rep 23:61-7. 2010
    ..05). These results indicate that HOXA10 expression could contribute to cancer progression and prognosis and that HOXA10 may be a potential diagnostic marker and a therapeutic target for OSCCs...
  43. ncbi Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management
    Isaac van der Waal
    Department of Oral and Maxillofacial Surgery Pathology, VU University Medical Center Academic Centre for Dentistry Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Oral Oncol 46:423-5. 2010
    ..At present, oral lichen planus is more or less accepted as being a potentially malignant disorder. There are no means to prevent such event. The efficacy of follow-up of oral lichen planus is questionable...
  44. pmc Changing trends in oral squamous cell carcinoma with particular reference to young patients: 1971-2006. The Emory University experience
    Susan Muller
    Department of Pathology and Laboratory Medicine, Emory University Hospital, Emory University School of Medicine, 1364 Clifton Road, NE, Atlanta, GA 30322, USA
    Head Neck Pathol 2:60-6. 2008
    ..The aim of this study is to determine whether there has been an increase in the number of cases of OSCC diagnosed in patients < 40 years old by our biopsy service from 1971 to 2006...
  45. pmc Overexpression of beta2-microglobulin is associated with poor survival in patients with oral cavity squamous cell carcinoma and contributes to oral cancer cell migration and invasion
    C H Chen
    Department of Otolaryngology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Br J Cancer 99:1453-61. 2008
    ..Taken together, our results suggest that beta2M expression in the tissues is associated with survival and may be involved in tumour progression and metastasis in OCSCC...
  46. pmc Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients
    Waseem Jerjes
    UCLH Head and Neck Centre, London, UK
    Head Neck Oncol 2:9. 2010
    ..Several clinicopathological parameters can be employed to assess outcome, recurrence and overall survival...
  47. ncbi Single nucleotide polymorphisms of DNA repair genes XRCC1 and XPD and its molecular mapping in Indian oral cancer
    Surya Ramachandran
    Department of Molecular Medicine, Regional Cancer Centre, Thiruvananthapuram 695 011, India
    Oral Oncol 42:350-62. 2006
    ..These results suggest that polymorphisms in functionally important repair genes, specifically, those that map onto the protein surface may alter protein function without significantly affecting its structure...
  48. pmc Viable bacteria present within oral squamous cell carcinoma tissue
    Samuel J Hooper
    Department of Oral Surgery, Medicine and Pathology, Cardiff University, Cardiff CF14 4XY, United Kingdom
    J Clin Microbiol 44:1719-25. 2006
    ..A diversity of bacterial groups have been isolated from within oral squamous cell carcinoma tissue. The significance of these bacteria within the tumor warrants further study...
  49. pmc Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis
    Y Kouzu
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Br J Cancer 94:717-23. 2006
    ..029). These results suggest that expression of stathmin could contribute to cancer progression/prognosis, and that stathmin may have potential as a biomarker and a therapeutic target for OSCC...
  50. ncbi Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus
    Aimee R Kreimer
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
    J Infect Dis 189:686-98. 2004
    ..8; 95% confidence interval, 3.1-52.7) among HIV-seropositive individuals. HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection...
  51. ncbi Activation of WNT family expression and signaling in squamous cell carcinomas of the oral cavity
    M Uraguchi
    Department of Oral Surgery, Graduate School of Dentistry, The Nippon Dental University, Tokyo, Japan
    J Dent Res 83:327-32. 2004
    ..These results suggest that enhanced WNT expression and signaling accelerate the progression of carcinomas via activating EMTs and local invasiveness...
  52. ncbi Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan
    Ching Yu Yen
    Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Tainan, and School of Dentistry, Taipei Medical University, Taipei, Taiwan
    J Oral Pathol Med 37:271-7. 2008
    ..In this study, we focused on the joint effect for SNP combinations of four DNA repair genes, X-ray repair cross-complementing groups (XRCCs) 1-4, involved in major cancer-related pathways...
  53. ncbi Clinicopathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma
    Paolo Garzino-Demo
    Division of Maxillofacial Surgery, Giovanni Battista Hospital, University of Turin, Italy
    J Craniomaxillofac Surg 34:344-50. 2006
    ..This report analysed the outcome of patients undergoing surgery for oral squamous cell carcinoma in order to identify the prognostic value of several factors...
  54. ncbi Cytologic and DNA-cytometric very early diagnosis of oral cancer
    D Maraki
    Department of Oral Surgery, Heinrich Heine University, Duesseldorf, Germany
    J Oral Pathol Med 33:398-404. 2004
    ..The aim of this study was to evaluate the diagnostic accuracy of exfoliative cytology (EC) and DNA-image cytometry applied to suspicious oral lesions compared with synchronous histology...
  55. ncbi MicroRNAs: new actors in the oral cancer scene
    Bo Hai Wu
    Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, People s Republic of China
    Oral Oncol 47:314-9. 2011
    ..Also, these missexpressed miRNAs have been shown to have potential as novel diagnostic, prognostic and therapeutic tools, which are expected to advance the clinical management of OSCC in the near future...
  56. ncbi Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma
    Patrick K Ha
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, 601 North Caroline Street, 6th Floor, Baltimore, MD 21287 0910, USA
    Lancet Oncol 7:77-82. 2006
    ..The substantial contribution of methylation, specifically in oral squamous-cell carcinoma, is now being realised and investigated...
  57. ncbi Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma
    Erina Nakamura
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo 113 8510, Japan
    Cancer Sci 99:1390-400. 2008
    ....
  58. ncbi Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma
    Daisuke Uchida
    Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, 3 18 15 Kuramoto, Tokushima 770 8504, Japan
    Exp Cell Res 290:289-302. 2003
    ..These results indicate that SDF-1/CXCR4 signaling may be involved in the establishment of lymph node metastasis in oral SCC via activation of both ERK1/2 and Akt/PKB induced by SFKs...
  59. ncbi Burden of potentially human papillomavirus-associated cancers of the oropharynx and oral cavity in the US, 1998-2003
    A Blythe Ryerson
    Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer 113:2901-9. 2008
    ..The objective of the current study was to describe the incidence rates of oropharyngeal and oral cavity cancers in the US with a focus on anatomic sites potentially associated with HPV infection...
  60. ncbi Global oral health inequalities in incidence and outcomes for oral cancer: causes and solutions
    N W Johnson
    Griffith Health Institute, Griffith University, Queensland, Australia
    Adv Dent Res 23:237-46. 2011
    ..Basic research aimed at determining individual predisposition and acquired genetic determinants of carcinogenesis and tumor progression, thus allowing for targeted therapies, should be pursued opportunistically...
  61. pmc Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions
    Anne S Tsao
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Prev Res (Phila) 2:931-41. 2009
    ..Higher doses of GTE may improve short-term (12-week) OPL outcome. The present results support longer-term clinical testing of GTE for oral cancer prevention...
  62. ncbi An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas
    Paul Roepman
    Department of Physiological Chemistry, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nat Genet 37:182-6. 2005
    ..The results show that the metastatic state can be deciphered from the primary tumor gene-expression pattern and that treatment can be substantially improved...
  63. ncbi Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity
    C H Chen
    Department of Otolaryngology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Oncogene 28:2723-37. 2009
    ..These findings suggest that FLJ10540 is not only an important prognostic factor but also a new therapeutic target in the FLJ10540/FOXM1/MMP-2 pathway for OCSCC treatment...
  64. ncbi Analysis of risk factors of predictive local tumor control in oral cavity cancer
    Chun Ta Liao
    Department of Otorhinolaryngology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    Ann Surg Oncol 15:915-22. 2008
    ..In this study, we sought to determine the independent prognosticators for local tumor control, disease-specific survival (DSS), and overall survival (OS) rates in a series of OSCC patients undergoing radical surgery...
  65. ncbi Arsenic trioxide enhances the therapeutic efficacy of radiation treatment of oral squamous carcinoma while protecting bone
    Pawan Kumar
    Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University Avenue, Room no 5205, Ann Arbor, MI 48109, USA
    Mol Cancer Ther 7:2060-9. 2008
    ..These results suggest a novel strategy to enhance the therapeutic efficacy of radiation treatment while protecting bone from the adverse effects of therapeutic radiation...
  66. ncbi Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma
    Keisuke Sugahara
    RadGenomics Project, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    Int J Oncol 39:761-9. 2011
    ..0035). Two amplification cores at the 11q13 region may have biological impacts on OSCC cells to spread from the primary site to local lymph nodes. Further study of a larger patient series should be conducted to validate these results...
  67. ncbi Cell adhesion molecules and oral cancer
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Crit Rev Oral Biol Med 12:479-98. 2001
    ..However, up-regulation of certain integrins, such as alphavbeta6, has consistently been found in oral cancer, suggesting that it may play an active role in disease progression...
  68. ncbi Hypoxia enhances CXCR4 expression by activating HIF-1 in oral squamous cell carcinoma
    Tohru Ishikawa
    Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791 0295, Japan
    Oncol Rep 21:707-12. 2009
    ..These results indicated that HIF-1alpha regulated hypoxia-induced CXCR4 expression in OSCC...
  69. ncbi IGF-1R expression predicts clinical outcome in patients with locally advanced oral squamous cell carcinoma
    Pedro C Lara
    Radiation Oncology Department, Hospital Universitario de Gran Canaria Dr Negrin, Spain
    Oral Oncol 47:615-9. 2011
    ..016), Disease-Free Survival (P=0.029), and Survival (P=0.009) in patients achieving tumour stages III-IV. Low IGF-1R expression was related to better long-term control in patients suffering locally advanced oral carcinoma...
  70. pmc Integrative analysis of DNA copy number and gene expression in metastatic oral squamous cell carcinoma identifies genes associated with poor survival
    Chang Xu
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA
    Mol Cancer 9:143. 2010
    ....
  71. pmc Gene expression profiling predicts the development of oral cancer
    Pierre Saintigny
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Cancer Prev Res (Phila) 4:218-29. 2011
    ..Our results show that gene expression profiles may improve the prediction of oral cancer risk in OPL patients and the significant genes identified may serve as potential targets for oral cancer chemoprevention...
  72. ncbi Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption
    Young Sun Hwang
    Oral Cancer Research Institute, Yonsei University College of Dentistry, Republic of Korea
    Oral Oncol 48:40-8. 2012
    ..LPA-induced IL-6 and IL-8 exerted propound effects on RANKL expression in osteoblast and thereby promoted osteoclast formation from osteoclast precursors...
  73. ncbi Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice
    Xiao Han Tang
    Departments of Pharmacology and Pathology, Weill Medical College of Cornell University, New York, New York
    Clin Cancer Res 10:301-13. 2004
    ..We have developed a mouse model using the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in the drinking water to induce tumorigenesis in the mouse oral cavity...
  74. ncbi Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC)
    Ching Yu Yen
    Department of Oral and Maxillofacial Surgery, Chi Mei Medical Center, Tainan, Taiwan
    Biomarkers 18:63-72. 2013
    ..Some extracellular matrix genes as prognostic biomarkers for oral squamous cell carcinoma (OSCC) were evaluated...
  75. ncbi Early diagnosis in primary oral cancer: is it possible?
    Isaac van der Waal
    Department of Oral and Maxillofacial Surgery Oral Pathology, VUmc ACTA, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Med Oral Patol Oral Cir Bucal 16:e300-5. 2011
    ..Dentists and physicians, and also oral hygienists and nurse practitioners, may play a valuable role in such screening programs...
  76. ncbi Baicalein induces G1 arrest in oral cancer cells by enhancing the degradation of cyclin D1 and activating AhR to decrease Rb phosphorylation
    Ya Hsin Cheng
    Department of Physiology, School of Medicine, China Medical University, Taichung 40402, Taiwan, ROC
    Toxicol Appl Pharmacol 263:360-7. 2012
    ....
  77. ncbi Genetics/epigenetics of oral premalignancy: current status and future research
    M W Lingen
    Department of Pathology, The University of Chicago Pritzker School of Medicine, Chicago, IL, USA
    Oral Dis 17:7-22. 2011
    ..In addition, recommendations for future research studies directed at defining the predictive capacity of specific biomarkers in this modeling are presented...
  78. ncbi Prognostic value of the sixth edition of the UICC's TNM classification and stage grouping for oral cancer
    Matthias Kreppel
    Department for Oral and Cranio maxillo and Facial Plastic Surgery, University of Cologne, Cologne, Germany
    J Surg Oncol 102:443-9. 2010
    ..The staging system is under continuous revision. The aim of our study was to assess the prognostic value of the UICC sixth edition for oral cancer, which was established in 2003...
  79. ncbi National prevalence of oral HPV infection and related risk factors in the U.S. adult population
    A E Sanders
    Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7450, USA
    Oral Dis 18:430-41. 2012
    ..The results also provide population data that help evaluate the likely public health benefits of prophylactic vaccination against oral HPV acquisition...
  80. ncbi Four-protein signature accurately predicts lymph node metastasis and survival in oral squamous cell carcinoma
    Sharifah Nurain Syed Zanaruddin
    Oral Cancer Research Team, Cancer Research Initiatives Foundation, 2nd Floor Outpatient Centre, Sime Darby Medical Centre, 47500 Subang Jaya, Selangor, Malaysia
    Hum Pathol 44:417-26. 2013
    ....
  81. ncbi Isoliquiritigenin 2'-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1
    Young Man Lee
    Department of Oral and Maxillofacial Pathology, Wonkwang University, Iksan, South Korea
    Toxicol In Vitro 24:776-82. 2010
    ..Thus, ILME could be considered to be a potential chemotherapeutic target for anti-oral cancer treatment strategies...
  82. ncbi Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms
    Jingjing Quan
    School of Dentistry, Medical Science, Griffith University, Gold Coast, Australia
    Cancer Metastasis Rev 31:209-19. 2012
    ..With all these studies and some recent discoveries in our own laboratory, an enhanced understanding of bone invasion will be achieved, which should indicate potential molecular targets for future biotherapies...
  83. ncbi Genetic and molecular alterations associated with oral squamous cell cancer (Review)
    Mario Perez-Sayans
    Facultad de Odontologia, Santiago de Compostela, CP 15782, Spain
    Oncol Rep 22:1277-82. 2009
    ..The purpose of the review is to explore the genetic and molecular alterations associated with OSCC...
  84. pmc Oral squamous cell cancer: early detection and the role of alcohol and smoking
    Anna G Zygogianni
    Kapodistrian University of Athens, Greece
    Head Neck Oncol 3:2. 2011
    ..Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome...
  85. ncbi Characteristics of a cancerous cell line, HIOEC-B(a)P-96, induced by benzo(a)pyrene from human immortalized oral epithelial cell line
    Lai ping Zhong
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China
    Arch Oral Biol 53:443-52. 2008
    ..It is also the first in vitro cancerous cell line of OSCC in China derived from immortalized oral epithelial cells...
  86. ncbi Expression of growth differentiation factor 15 is positively correlated with histopathological malignant grade and in vitro cell proliferation in oral squamous cell carcinoma
    Lei Zhang
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, China
    Oral Oncol 45:627-32. 2009
    ..Based on these observations, we conclude that GDF15 is a positive gene of OSCC development and progression and GDF15 can be used as an additional marker for histopathologic evaluation of OSCC differentiation...
  87. ncbi Significance of stromal desmoplasia and myofibroblast appearance at the invasive front in squamous cell carcinoma of the oral cavity
    Shuichi Kawashiri
    Department of Oral and Maxillofacial Surgery, Division of Cancer Science, Graduate School of Medical Science, Kanazawa University, Kanazawa Ishikawa 920 8640, Japan
    Head Neck 31:1346-53. 2009
    ..Tumor invasion involves complex interactions between tumor and stromal cells. We examined the extent of connective tissue in the tumor stroma and whether myofibroblasts play a role in assisting cancer invasion and metastasis...
  88. ncbi Dickkopf-1 in human oral cancer
    Kenji Ogoshi
    Department of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Oncol 39:329-36. 2011
    ..The current study suggested that Dkk1 plays an important role in regulating cellular migration and invasiveness, making Dkk1 a potential biomarker for early detection of lymph node metastasis in OSCCs...
  89. ncbi Oral cancer
    Deepak Kademani
    Division of Oral Diagnosis and Oral and Maxillofacial Surgery, Mayo Clinic, 200 First St SW, Rochester, Minn 55905, USA
    Mayo Clin Proc 82:878-87. 2007
    ..To improve survival, all patients should be routinely and vigilantly screened for oral mucosal lesions...
  90. ncbi Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature
    Monica Pentenero
    Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, University of Turin, Clinica Odontostomatologica, Sezione di Patologia e Medicina Orale, Corso Dogliotti 38, 10126 Torino, Italy
    Head Neck 27:1080-91. 2005
    ..Many parameters have been studied to identify N0 patients with a high likelihood of harboring occult node metastases or of having them develop...
  91. ncbi Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma
    Julia A Woolgar
    Oral Pathology, Liverpool University Dental Hospital, Pembroke Place, Liverpool L3 5PS, United Kingdom
    Oral Oncol 42:229-39. 2006
    ....
  92. ncbi Treatment and follow-up of oral dysplasia - a systematic review and meta-analysis
    Hisham M Mehanna
    Department of Head and Neck Surgery, Institute of Head and Neck Studies and Education, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom
    Head Neck 31:1600-9. 2009
    ..The aim of this study was to inform an evidence-based management policy for oral dysplastic lesions...
  93. pmc Human Papilloma Virus (HPV) in head and neck region: review of literature
    L Mannarini
    Department of Otolaryngology HN Surgery, University of Pavia, IRCCS Policlinico S Matteo Foundation, Pavia, Italy
    Acta Otorhinolaryngol Ital 29:119-26. 2009
    ..This review summarizes current knowledge regarding human papillomavirus biology, oncogenic mechanisms, risk factors for transmission, clinical significance and prophylactic strategies...
  94. ncbi Neoadjuvant concurrent radiochemotherapy followed by surgery in advanced oral squamous cell carcinoma (OSCC): a retrospective analysis of 207 patients
    Kolja Freier
    Klinik für Mund Kiefer Gesichtschirurgie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Oral Oncol 44:116-23. 2008
    ..Those therapy non-responders might profit from intensified systemic therapy approaches...
  95. pmc Human papillomavirus-16 infection in advanced oral cavity cancer patients is related to an increased risk of distant metastases and poor survival
    Li Ang Lee
    Head and Neck Oncology Group, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
    PLoS ONE 7:e40767. 2012
    ..Human papillomavirus (HPV) is an oncogenic virus causing oropharyngeal cancers and resulting in a favorable outcome after the treatment. The role of HPV in oral cavity squamous cell carcinoma (OSCC) remains ambiguous...
  96. ncbi Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis
    Zhi Jiang Zhang
    Department of Epidemiology, School of Public Health, Shanghai Jiao Tong University, 227 Chongqing South Road, Shanghai, China
    Am J Epidemiol 173:847-57. 2011
    ..The GSTT1 null genotype may not be associated with oral cancer...
  97. ncbi Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
    J H Jeng
    Laboratory of Dental Pharmacology and Toxicology, College of Medicine, Graduate Institute of Clinical Dental Science, National Taiwan University, No 1 Chang Te Street, Taipei, Taiwan
    Oral Oncol 37:477-92. 2001
    ..Further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, in order to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis...
  98. ncbi Prognostic impact of intraoperative microscopic cut-through on frozen section in oral cavity squamous cell carcinoma
    Jennifer P Guillemaud
    Department of Otolaryngology Head and Neck Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario
    J Otolaryngol Head Neck Surg 39:370-7. 2010
    ..Therefore, this study aimed to analyze the influence of microscopic tumour cut-through on disease recurrence and survival and to establish clinicopathologic variables associated with tumour cut-through...
  99. ncbi Prognostic significance of N-Cadherin expression in oral squamous cell carcinoma
    M Di Domenico
    Department of General Pathology, Second University of Naples, Via L De Crecchio, 7, 80138 Naples, Italy
    Anticancer Res 31:4211-8. 2011
    ..The aim of the present work was to define the prognostic role of N-Cadherin in a large series of oral squamous cell carcinomas (OSCCs)...
  100. pmc Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas
    A Torres-Rendon
    Department of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
    Br J Cancer 100:1128-34. 2009
    ..04), likewise there was a significant increase in the Mcm2/Ki67 and geminin/Ki67 ratios (P=0.04 and 0.02 respectively). Mcm2 and geminin proteins seem to be novel biomarkers of growth and may be useful prognostic tools for OED...
  101. pmc Caspase-mediated cleavage of RNA-binding protein HuR regulates c-Myc protein expression after hypoxic stress
    Sudha Talwar
    Department of Craniofacial Biology, College of Dental Medicine, Medical University of SouthCarolina, Charleston, South Carolina 29425, USA
    J Biol Chem 286:32333-43. 2011
    ..These findings suggest an important role for HuR in hypoxia, and we may have revealed a novel post-transcriptional mechanism that controls c-Myc expression in oral cancer progression...

Research Grants58

  1. Therapeutic targets for viral and non-viral-associated oral neoplasms
    David Azorsa; Fiscal Year: 2011
    ....
  2. Evaluating Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
    Jon Ebbert; Fiscal Year: 2009
    ..No drug therapies have been shown to be effective for helping smokeless tobacco users quit for good. The purpose of this study is to test drugs that can be used to help smokeless tobacco users quit for good. ..
  3. ORAL CANCER RESEARCH CENTER
    JEFFREY ENGLER; Fiscal Year: 2001
    ..In addition, there are significant clinical, basic science, and administrative resources available to insure the success of the Center. ..
  4. FLAVONOID BIOAVAILABILITY IN HUMANS-CELLULAR STUDIES
    Thomas Walle; Fiscal Year: 2005
    ..The findings from the proposed studies should help us understand the bioavailability of the flavonoids, facilitating optimization of the chemopreventive utility of these natural or synthetic compounds. ..
  5. North Carolina Needs Assessment for Oral Cancer Control
    Lauren Patton; Fiscal Year: 2003
    ....
  6. Oral Cancer, Chemoprevention, and Anti-Angiogenesis
    Mark Lingen; Fiscal Year: 2009
    ..abstract_text> ..
  7. MOLECULAR DETERMINANTS OF ANGIOGENSIS IN ORAL CANCER
    Mark Lingen; Fiscal Year: 2005
    ....
  8. COGNITIVE AND EMOTIONAL RESPONSES TO AN HPV DIAGNOSIS IN MEN
    Ellen M Daley; Fiscal Year: 2010
    ..These data will assist in the planning, implementation, and evaluation of interventions to reduce HPV infection in both sexes. ..
  9. Molecular Profiling of Premalignant Oral Lesions
    Mark Lingen; Fiscal Year: 2008
    ..This molecular analysis may also greatly improve diagnostic prediction compared to the cellular pattern recognition currently used by pathologists. [unreadable] [unreadable]..
  10. Oral Health Disparities: Actions Taken About Pain
    Joseph Riley; Fiscal Year: 2007
    ..This information has important health policy implications for reducing the race and ethnic disparities in oral health through interventions that facilitate access to care and utilization of appropriate services. ..
  11. Automated Tissue Arrayer
    Mark Lingen; Fiscal Year: 2004
    ..An already established Internal Advisory Committee will oversee an equitable and appropriate use by a broad disciplinary group of scientists while giving priority to NIH-supported groups. ..
  12. Association between oral health of mothers and their children
    CLEMENCIA VARGAS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Psychological distress in survivors of head/neck cancer
    Henrietta Logan; Fiscal Year: 2006
    ..abstract_text> ..
  14. Behavior Modification, Dentists and Oral Cancer Control
    Sol Silverman; Fiscal Year: 2006
    ..This project will also explore potential for use of the standardized continuing education program for other health care professionals, e.g., dental hygienists, nurse practitioners and primary care physicians. ..
  15. Regulatory function of fyn in oral SCC invasion
    Daniel M Ramos; Fiscal Year: 2010
    ..abstract_text> ..
  16. ORAL MELANOMA: ALPHA V BETA 3 EXPRESSION AND METASTASIS
    Daniel Ramos; Fiscal Year: 2004
    ..Understanding the role beta3 plays in oral melanoma invasion and metastasis may lead to novel prognostic indicators and development of new treatment strategies. ..
  17. Animal Model of Proliferative Verrucous Leukoplakia
    Valerie Murrah; Fiscal Year: 2002
    ....
  18. HPV Clearance by Folic Acid Supplementation
    Chandrika J Piyathilake; Fiscal Year: 2010
    ..Because this study will be conducted among women positive for HPV 16, the most prevalent and powerful causative agent of CC, the public health significance of this study could be enormous and will complement HPV vaccine studies. ..
  19. A Therapeutic Vaccine for HPV 16-Positive Head and Neck Cancer
    Maura Gillison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Biofilm Chemoprevention of Head/Neck Skin Cancer
    Zhi Wang; Fiscal Year: 2005
    ..This is the first study to use polymer biofilm technique for NMSC chemoprevention on head/neck region. We believe that a successful study will greatly benefit patients. ..
  21. Imaging Evaluation of Cancer Chemoprevention
    Zhi Wang; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. Molecular Epidemiology of Endometrial Cancer
    Chu Chen; Fiscal Year: 2007
    ..Efforts will also be devoted to generating risk indices through statistical modeling that integrate potential effects of genetic variants in the estrogen metabolism pathway and/or DNA repair pathways. ..
  23. DNA Markers As Surrogates:Melanoma Patient Response
    Dave Hoon; Fiscal Year: 2008
    ..The R33 phase will focus on validating the PGMs and determining their clinical utility in an ongoing prospective multicenter Phase II BC and maintenance Biotherapy trial for AJCC stage IV melanoma patients. ..
  24. MOLECULAR EPIDEMIOLOGY OF LUNG CANCER
    Chu Chen; Fiscal Year: 2010
    ..g. Rosaceae fruits and Cruciferae vegetables), and food-derived nutrients (e.g. carotenoids, vitamin C, and vitamin E). ..
  25. Oral/Pharyngeal Cancer Incidence from Medicare Claims
    Jonathan Mahnken; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. RCT of Family Focused Grief Therapy in Palliative Care & Bereavement
    DAVID WILLIAM KISSANE; Fiscal Year: 2010
    ..Bereavement care will be approached preventively with a continuity of care model. ..
  27. ORAL CANCER: MOLECULAR PROFILES & CLINICAL OUTCOMES
    Chu Chen; Fiscal Year: 2010
    ..HPV plays an important etiologic role in some oropharyngeal cancers, we plan to determine and incorporate HPV genotypes in the analyses and interpretation of the study findings. ..
  28. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ....
  29. Immunization of Stem Cell Transplant Donors to Enhance Graft-versus-Tumor Effect
    Larry Kwak; Fiscal Year: 2008
    ..Cell Line Disclosure Permission Statement. Applicable to SBIR/STTR Only. See SBIR/STTR instructions. Yes No ..
  30. Novel Approaches to the Assessment of Oral Mucosal Immu*
    Theresa Whiteside; Fiscal Year: 2003
    ..A better understanding of oral immunity in normal and HIV-infected mucosa is important for the development of new antiviral therapies, including oral antiviral vaccines. ..
  31. MR Dynamic Imaging and Spectroscopy in Head & Neck Cancers
    AMITA DAVE; Fiscal Year: 2010
    ..If successful, it will provide an a priori predictor of failure/response to chemotherapy and/or long term disease free-survival, resulting in patient specific treatment which will likely enhance outcome. ..
  32. The Coronary Screening for Kidney Transplantation (COST) Study
    Bertram Kasiske; Fiscal Year: 2008
    ..The money spent on these procedures might be better directed to health care measures of proven efficacy. [unreadable] [unreadable] [unreadable]..
  33. Periodontal Disease and the Incidence of Oral Cancer
    Mine Tezal; Fiscal Year: 2007
    ..Prevention of oral cancer could begin with prevention and early treatment of periodontitis. [unreadable] [unreadable] [unreadable]..
  34. Array-based outcome prediction in head and neck cancer
    Thomas Belbin; Fiscal Year: 2005
    ..the products of identified prognostic genes using immunohistochemical techniques with commercially available antibodies using a HNSCC tissue array constructed in the Department of Pathology and Montefiore Medical Center ..
  35. Monitoring tobacco mortality in 2M adults in 4 countries
    Richard Peto; Fiscal Year: 2004
    ..We already have evidence that this has taken place in China, where the earliest study was established. ..
  36. Chemoprevention of Oral Dysplasia by Black Raspberries
    Susan Mallery; Fiscal Year: 2005
    ..This experimental design (comparison of pretreatment and post-treatments tissues) permits each patient to serve as their own internal control. ..
  37. DONOR SPECIFIC IMMUNOSUPPRESSION TO TRACHEAL ALLOGRAFTS
    Eric Genden; Fiscal Year: 2004
    ..Specific Aim II will focus on alternative methods of inducing donor specific tolerance to tracheal allografts. Specific Aim III will focus on the behavior of the tracheal allograft and its affect upon the established state of tolerance. ..
  38. DNA-Based Vaccines for Oral Carcnoma
    Theresa Whiteside; Fiscal Year: 2005
    ....
  39. HERPES SIMPLEX VIRUS IN THE TREATMENT OF ORAL CANCER
    EDWARD SHILLITOE; Fiscal Year: 2004
    ..abstract_text> ..
  40. Rapamycin as an Antineoplastic Agent
    Ezra Cohen; Fiscal Year: 2006
    ..At the conclusion of the trial RAPA toxicity and effect on p-S6K will be defined over a range of doses as well as the MTD for use in future studies that will develop this agent. ..
  41. Formulation & Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention
    Susan Mallery; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  42. Adoption of Pharmacotherapy in Alcoholism Treatment
    Peter Miller; Fiscal Year: 2005
    ..abstract_text> ..
  43. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..
  44. Role of Cystatins in Oral Cancer Metastasis
    Nadarajah Vigneswaran; Fiscal Year: 2007
    ..Insights gained from these studies will be used to design therapeutic strategies for restoring immune competence of OSCC patients to prevent and eradicate OSCC metastasis. [unreadable] [unreadable] [unreadable]..
  45. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..Our ultimate goal is to provide information to identify women at high risk of breast cancer, and to aid in the formulation of prevention strategies for these women. ..
  46. Role of Oxidants & Angiogenesis in Kaposi's Sarcoma
    Susan Mallery; Fiscal Year: 2007
    ..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..
  47. Facilitating Alcohol Screening of Hypertensive Patients
    Peter Miller; Fiscal Year: 2006
    ..Such screening and intervention should improve blood pressure control in many of these patients and, in turn, reduce risk of chronic disease and death. ..
  48. Live Unrelated Kidney Donor & Sibling Follow-up Study
    Bertram Kasiske; Fiscal Year: 2005
    ..Altogether, this study will provide useful information that will improve the informed consent for living kidney donors and enhance our knowledge of the role of the kidney, if any, in CVD. ..
  49. Functional Infrared Imaging Predicts Radiation Mucositis
    Ezra Cohen; Fiscal Year: 2008
    ..Such a tool would have wide applicability in this patient population and would have tremendous impact on their treatment. [unreadable] [unreadable] [unreadable]..
  50. Health Literacy and Oral Health Knowledge
    MARK MACEK; Fiscal Year: 2007
    ..It is anticipated that these results will ultimately improve oral health and eliminate disparities in the United States. [unreadable] [unreadable] [unreadable]..
  51. Oral cancer treatment & complications: Cochrane reviews
    Helen Worthington; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  52. Novel, Noninvasive Biomarker of Fruit & Vegetable Intake
    Susan Mayne; Fiscal Year: 2005
    ..abstract_text> ..
  53. Evaluation of Enteral Stent Placement Using Claims Data
    Sujha Subramanian; Fiscal Year: 2004
    ..abstract_text> ..
  54. Yale/NCI Cooperative Training Program in Cancer Epidemiology
    Susan Mayne; Fiscal Year: 2007
    ..We anticipate that graduates of this program will be uniquely qualified to be future leaders in the field of cancer epidemiology and genetics. [unreadable] [unreadable] [unreadable] [unreadable]..
  55. RANDOMIZED ADJUVANT THERAPY OF HEAD AND NECK CANCER
    Dong Shin; Fiscal Year: 2001
    ....
  56. Chemoprevention of Head and Neck Cancer with ZD1839 and Celecoxib
    Dong Shin; Fiscal Year: 2008
    ..Biomarker changes will be correlated with cancer incidence by statistical analyses. We will also determine whether such biomarker changes can serve as intermediate endpoint(s) in this chemopreventive trial. ..