urticaria

Summary

Summary: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.

Top Publications

  1. ncbi Quality of life and patients' satisfaction in chronic urticaria and respiratory allergy
    I Baiardini
    Allergy and Respiratory Diseases, DIMI, Genoa University, Genoa, Italy
    Allergy 58:621-3. 2003
  2. ncbi Plasma IL-6 concentration correlates with clinical disease activity and serum C-reactive protein concentration in chronic urticaria patients
    A Kasperska-Zajac
    Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland
    Clin Exp Allergy 41:1386-91. 2011
  3. ncbi EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria
    T Zuberbier
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 64:1427-43. 2009
  4. ncbi Acute-phase response in chronic urticaria
    A Kasperska-Zajac
    Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland
    J Eur Acad Dermatol Venereol 26:665-72. 2012
  5. ncbi Coagulation/fibrinolysis and inflammation markers are associated with disease activity in patients with chronic urticaria
    S Takahagi
    Department of Dermatology, Hiroshima University, Japan
    Allergy 65:649-56. 2010
  6. ncbi EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria
    T Zuberbier
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 64:1417-26. 2009
  7. ncbi Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria
    Marcus Maurer
    Department of Dermatology and Allergy, Charite Universitatsmedizin, Berlin
    N Engl J Med 368:924-35. 2013
  8. ncbi How to assess disease activity in patients with chronic urticaria?
    A Młynek
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 63:777-80. 2008
  9. ncbi Activation of blood coagulation in plasma from chronic urticaria patients with negative autologous plasma skin test
    R Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
    J Eur Acad Dermatol Venereol 25:201-5. 2011
  10. ncbi A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria
    Sarbjit Saini
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 128:567-73.e1. 2011

Research Grants

  1. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
  2. Complement protein synthesis and activation by human mast cells
    Yoshihiro Fukuoka; Fiscal Year: 2010
  3. IgE to carbohydrates causes delayed anaphylaxis
    SCOTT PALMER COMMINS; Fiscal Year: 2013
  4. Human Basophil Phenotypes and Therapeutic Outcomes
    Donald W Macglashan; Fiscal Year: 2013
  5. PATHOGENESIS OF ALLERGIC DISEASES OF THE SKIN & LUNGS
    Allen Kaplan; Fiscal Year: 1992
  6. Identification of Dysregulated Stress Response Mechanisms in Chronic Urticaria
    Marcia J Slattery; Fiscal Year: 2013
  7. OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSING
    Thomas Robins; Fiscal Year: 2001
  8. ASTHMA--ALLERGY AND AUTOIMMUNITY
    ENG TAN; Fiscal Year: 1990
  9. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
  10. HUMAN SKIN MAST CELL GRANULE ENZYMES--SKIN DISEASES
    BRUCE WINTROUB; Fiscal Year: 1992

Detail Information

Publications279 found, 100 shown here

  1. ncbi Quality of life and patients' satisfaction in chronic urticaria and respiratory allergy
    I Baiardini
    Allergy and Respiratory Diseases, DIMI, Genoa University, Genoa, Italy
    Allergy 58:621-3. 2003
    Few articles are available about chronic urticaria (CU) impact on patients' quality of life (QoL). The aim of our study was to evaluate QoL in CU patients both focusing on health status and subjective satisfaction...
  2. ncbi Plasma IL-6 concentration correlates with clinical disease activity and serum C-reactive protein concentration in chronic urticaria patients
    A Kasperska-Zajac
    Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland
    Clin Exp Allergy 41:1386-91. 2011
    Our previous study was the first to demonstrate enhanced plasma IL-6 concentrations in chronic urticaria (CU)...
  3. ncbi EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria
    T Zuberbier
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 64:1427-43. 2009
    This guideline, together with its sister guideline on the classification of urticaria (Zuberbier T, Asero R, Bindslev-Jensen C, Canonica GW, Church MK, Giménez-Arnau AM et al...
  4. ncbi Acute-phase response in chronic urticaria
    A Kasperska-Zajac
    Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland
    J Eur Acad Dermatol Venereol 26:665-72. 2012
    ..Little information is available on the systemic inflammatory response in urticaria/angio-oedema...
  5. ncbi Coagulation/fibrinolysis and inflammation markers are associated with disease activity in patients with chronic urticaria
    S Takahagi
    Department of Dermatology, Hiroshima University, Japan
    Allergy 65:649-56. 2010
    The evaluation of disease severity and activity of chronic urticaria (CU) is essential for the adequate treatment of patients. However, there is no reliable biomarker for such evaluations...
  6. ncbi EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria
    T Zuberbier
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 64:1417-26. 2009
    This guideline, together with its sister guideline on the management of urticaria [Zuberbier T, Asero R, Bindslev-Jensen C, Canonica GW, Church MK, Giménez-Arnau AM et al. EAACI/GA(2)LEN/EDF/WAO Guideline: Management of urticaria...
  7. ncbi Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria
    Marcus Maurer
    Department of Dermatology and Allergy, Charite Universitatsmedizin, Berlin
    N Engl J Med 368:924-35. 2013
    Many patients with chronic idiopathic urticaria (also called chronic spontaneous urticaria) do not have a response to therapy with H-antihistamines, even at high doses...
  8. ncbi How to assess disease activity in patients with chronic urticaria?
    A Młynek
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 63:777-80. 2008
    The current EAACI/GA(2)LEN/EDF guidelines recommend assessing disease activity in chronic urticaria (CU) by using an established and well-defined symptom score, i.e...
  9. ncbi Activation of blood coagulation in plasma from chronic urticaria patients with negative autologous plasma skin test
    R Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
    J Eur Acad Dermatol Venereol 25:201-5. 2011
    ..serum skin test - ASST) and/or plasma (autologous plasma skin test - APST) is thought to identify chronic urticaria (CU) patients with an autoimmune/autoreactive disease...
  10. ncbi A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria
    Sarbjit Saini
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 128:567-73.e1. 2011
    Proof-of-concept studies with omalizumab in patients with chronic idiopathic urticaria (CIU) have shown significant decreases in mean urticaria activity scores (UASs).
  11. pmc Strongyloides stercoralis is a cause of abdominal pain, diarrhea and urticaria in rural Cambodia
    Virak Khieu
    National Centre for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia
    BMC Res Notes 6:200. 2013
    ..stercoralis (more than 250 larvae in a single Baermann test) from a community in rural Cambodia, both before and three weeks after ivermectin (200 μg/kg BW, single oral dose) treatment...
  12. ncbi Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria
    Riccardo Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
    J Allergy Clin Immunol 119:705-10. 2007
    In patients with chronic urticaria (CU), plasma shows signs of thrombin generation and autologous plasma skin tests score positive in as many as 95% of cases.
  13. ncbi Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths
    David J Diemert
    Albert B Sabin Vaccine Institute, Washington, DC 20037, USA
    J Allergy Clin Immunol 130:169-76.e6. 2012
    ..Vaccination of laboratory animals with recombinant Na-ASP-2 provides significant protection against challenge infections. In endemic areas antibodies to Na-ASP-2 are associated with reduced risk of heavy N americanus infections...
  14. ncbi Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase
    Marcus Maurer
    Charite Universitatsmedizin Berlin, Allergie Centrum Charité, Klinik fur Dermatologie, Venerologie und Allergologie, Berlin, Germany
    J Allergy Clin Immunol 128:202-209.e5. 2011
    A subgroup of patients with chronic spontaneous urticaria (CU) exhibits IgE antibodies directed against autoantigens, such as thyroperoxidase (TPO)...
  15. ncbi Comparison of the efficacy and safety of bilastine 20 mg vs levocetirizine 5 mg for the treatment of chronic idiopathic urticaria: a multi-centre, double-blind, randomized, placebo-controlled study
    T Zuberbier
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Germany
    Allergy 65:516-28. 2010
    ..nonsedative H(1)-receptor antagonist, which may be used for the symptomatic treatment of chronic idiopathic urticaria (CU)...
  16. ncbi Chronic idiopathic urticaria: prevalence and clinical course
    Kanokvalai Kulthanan
    Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok, Thailand
    J Dermatol 34:294-301. 2007
    The purpose of our study was to assess the prevalence and clinical course of patients with chronic idiopathic urticaria (CIU), as well as possible causes or associated findings, laboratory findings and the duration of the disease in ..
  17. ncbi High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study
    Frank Siebenhaar
    Allergie Centrum Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Allergy Clin Immunol 123:672-9. 2009
    ..Allergy and Asthma European Network/European Dermatology Forum guidelines on patients with acquired cold urticaria (ACU) who do not respond satisfactorily to the standard dose...
  18. ncbi Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticaria
    Sridharan Soundararajan
    Department of Medicine, Division of Pulmonary Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    J Allergy Clin Immunol 115:815-21. 2005
    Chronic urticaria is caused by a complement fixing, IgG antibody directed to the alpha-subunit of the IgE receptor, which is present in 35% to 45% of patients...
  19. ncbi Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy
    Allen Kaplan
    Medical University of South Carolina, Charleston, SC, USA
    J Allergy Clin Immunol 132:101-9. 2013
    Patients with chronic idiopathic urticaria/chronic spontaneous urticaria (CIU/CSU) often continue to experience symptoms despite receiving standard-of-care therapy with H1-antihistamines along with 1 or more add-on therapies.
  20. ncbi Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Marco Gattorno
    Second Division of Pediatrics, IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3138-48. 2007
    ....
  21. ncbi Assessment of platelet activity as expressed by plasma levels of platelet factor 4 and beta-thromboglobulin in patients with chronic idiopathic urticaria
    Alicja Kasperska-Zajac
    Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Zabrze, Poland
    Exp Dermatol 14:515-8. 2005
    Blood platelet significance in inflammation is recognized but poorly characterized in urticaria. It is known that platelets are activated during inflammatory processes and are involved in modulating inflammatory and immune response via ..
  22. ncbi Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report
    M Maurer
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 66:317-30. 2011
    Chronic spontaneous urticaria, formerly also known as chronic idiopathic urticaria and chronic urticaria (CU), is more common than previously thought. At any time, 0.5-1% of the population suffers from the disease (point prevalence)...
  23. ncbi Acute phase inflammatory markers in patients with non-steroidal anti-inflammatory drugs (NSAIDs)-induced acute urticaria/angioedema and after aspirin challenge
    A Kasperska-Zajac
    Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland
    J Eur Acad Dermatol Venereol 27:1048-52. 2013
    Active chronic urticaria, identified as a mast cell- and basophil-dependent inflammatory disorder of the skin is able to elicit acute phase response (APR)...
  24. pmc Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria
    A Kasperska-Zajac
    Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Ul Ceglana 35, 40 952 Katowice, Poland
    Inflamm Res 62:309-12. 2013
    ..peripheral markers of acute phase response (APR) activation, C-reactive protein (CRP) and IL-6 in the context of urticaria activity and severity...
  25. ncbi Validation of basophil histamine release against the autologous serum skin test and outcome of serum-induced basophil histamine release studies in a large population of chronic urticaria patients
    M H Platzer
    National University Hospital, Allergy Clinic, Laboratory of Medical Allergology, Copenhagen, Denmark
    Allergy 60:1152-6. 2005
    Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU)...
  26. ncbi Multiple H1-antihistamine-induced urticaria
    Naoko Inomata
    Department of Environmental Immuno Dermatology, Yokohama City University School of Medicine, Yokohama, Japan
    J Dermatol 36:224-7. 2009
    ..Particularly, a cornerstone of the management of chronic idiopathic urticaria is treatment with H(1)-antihistamines...
  27. ncbi Patients with papular urticaria have IgG antibodies to bedbug (Cimex lectularius) antigens
    Mohamed Badawy Abdel-Naser
    Department of Dermatology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    Parasitol Res 98:550-6. 2006
    ..assessed in comparison with mosquito (Culex pipiens) and flea (Pulex irritans) antigens in the sera of papular urticaria patients (group I), siblings without papular urticaria (group IIa), patients' parents (group IIb), and healthy ..
  28. ncbi Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients
    E Toubi
    Division of Allergy and Clinical Immunology, Faculty of Medicine, Technion, Israel
    Allergy 59:869-73. 2004
    Despite the disabling nature of chronic urticaria (CU), little is known about the disease's duration or the efficacy of adopting aggressive therapeutic regimens such as cyclosporine A.
  29. ncbi Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005
    Leanne M Poulos
    Australian Centre for Asthma Monitoring, Camperdown, NSW, Australia
    J Allergy Clin Immunol 120:878-84. 2007
    ..Recent investigations in developed countries have found marked increases in the prevalence of allergic conditions...
  30. ncbi The role of interleukin-1 in allergy-related disorders
    Karoline Krause
    Autoinflammation Reference Center Charité, Charite Universitatsmedizin Berlin, Berlin, Germany
    Curr Opin Allergy Clin Immunol 12:477-84. 2012
    ..This review provides insights into recent advances of our understanding of the pathogenesis of IL-1β-associated allergy-related disorders...
  31. ncbi Increase of coagulation potential in chronic spontaneous urticaria
    T Takeda
    Department of Pediatrics, Nara Medical University School of Medicine, Kashihara, Nara 634 8522, Japan
    Allergy 66:428-33. 2011
    The pathogenesis of chronic spontaneous urticaria (CU) has recently been conceived to be associated with thrombin generation through the extrinsic coagulation pathway...
  32. ncbi Clinical evaluation of the computerized chronic urticaria-specific quality of life questionnaire in Korean patients with chronic urticaria
    Y M Ye
    Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
    Clin Exp Dermatol 37:722-8. 2012
    Chronic urticaria (CU) is a common skin disorder that affects the well-being and quality of life (QOL) of patients...
  33. ncbi Co-existence of chronic urticaria and metabolic syndrome: clinical implications
    Young Min Ye
    Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
    Acta Derm Venereol 93:156-60. 2013
    A systemic pro-inflammatory and pro-coagulating state occurs in subjects who have both chronic urticaria and metabolic syndrome...
  34. ncbi Pathogenesis of chronic urticaria
    A P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC, USA
    Clin Exp Allergy 39:777-87. 2009
    Chronic urticaria is defined as the presence of urticaria (hives) for at least 6 weeks with the assumption that it occurs daily or close to it...
  35. ncbi Generalised urticaria in a young woman treated with clomipramine and after ingestion of codfish
    L Gallelli
    Pharmacopsychiatry 39:154-6. 2006
    ..5 mg/day) was started. About one month later, the patient developed a severe generalized urticaria with intense itch...
  36. ncbi Association of Blastocystis hominis genetic subtypes with urticaria
    Dina M Abdel Hameed
    Parasitology Department, Faculty of Medicine, Ain Shams University, 13 B Kornesh El Nile, Aghakhan, Shobra, Cairo, Egypt
    Parasitol Res 108:553-60. 2011
    ..a possible cause of skin disorders, there are few case reports concerning the role of Blastocystis hominis in urticaria. To clarify this association, we determined the frequency of B...
  37. ncbi Blastocystis hominis associated acute urticaria
    Rajanshu Verma
    Division of Hospital Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Med Sci 346:80-1. 2013
    Acute urticaria has many causative factors, which may include infections, medications (nonsteroidal anti-inflammatory drugs, antibiotics, contraceptives and others), insect bites, physical stimuli, allergens or underlying systemic ..
  38. ncbi Immediate contact skin reactions, an update of Contact Urticaria, Contact Urticaria Syndrome and Protein Contact Dermatitis -- "A Never Ending Story"
    Ana Gimenez-Arnau
    Department of Dermatology, Hospital del Mar, Universitat Autonoma de Barcelona, Passeig Maritim 25 29, 08003 Barcelona, Spain
    Eur J Dermatol 20:552-62. 2010
    ..A good example is Immediate Contact Skin Reactions (ICSR) which manifest as Contact Urticaria Syndrome (CUS), Contact Urticaria (CU) and Protein Contact Dermatitis (PCD)...
  39. ncbi BSACI guidelines for the management of chronic urticaria and angio-oedema
    R J Powell
    Clinical Immunology Unit, Queen s Medical Centre, Nottingham, UK
    Clin Exp Allergy 37:631-50. 2007
    This guidance for the management of patients with chronic urticaria and angio-oedema has been prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI)...
  40. ncbi Increased mean platelet volume and C-reactive protein levels in patients with chronic urticaria with a positive autologous serum skin test
    Eli Magen
    Department of Medicine B, Barzilai Medical Center, Ben Gurion University of Negev, Ashkelon, Israel
    Am J Med Sci 339:504-8. 2010
    ..of the coagulation cascade resulting in thrombin production is a prominent feature of exacerbations in chronic spontaneous urticaria (CU). Autologous serum skin test (ASST) causes wheal-and-flare reactions in 30% to 50% of CU cases.
  41. ncbi A retrospective review of clinical presentation, thyroid autoimmunity, laboratory characteristics, and therapies used in patients with chronic idiopathic urticaria
    Umer Najib
    Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02445, USA
    Ann Allergy Asthma Immunol 103:496-501. 2009
    Our knowledge of autoimmune characteristics of chronic idiopathic urticaria (CIU) is limited.
  42. ncbi Increased circulating pro-inflammatory cytokines and imbalanced regulatory T-cell cytokines production in chronic idiopathic urticaria
    Juliana Cristina Dos Santos
    Laboratory of Dermatology and Immunodeficiencies LIM 56, Department of Dermatology, Medical School of the University of São Paulo, Sao Paulo, Brazil
    Int Immunopharmacol 8:1433-40. 2008
    The immunologic characterization of chronic idiopathic urticaria (CIU), mainly regarding cytokine profile needs more investigation...
  43. pmc Genetic markers for differentiating aspirin-hypersensitivity
    Seung Hyun Kim
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Youngtong Gu, Suwon 442 721, Korea
    Yonsei Med J 47:15-21. 2006
    Aspirin-induced asthma (AIA) and aspirin-induced urticaria/ angioedema (AIU) are two major aspirin-related allergies...
  44. ncbi Safety and efficacy of bilastine: a new H(1)-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria
    Martin K Church
    Allergie Centrum Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117, Berlin, Germany
    Expert Opin Drug Saf 10:779-93. 2011
    ..A review of bilastine was undertaken to determine whether this newer H(1)-antihistamine meets these requirements...
  45. ncbi Clinical and laboratory features of antihistamine-resistant chronic idiopathic urticaria
    Eli Magen
    Leumit Health Services, Tel Aviv, Israel
    Allergy Asthma Proc 32:460-6. 2011
    Chronic idiopathic (spontaneous) urticaria (CIU) is sometimes resistant to the conventional and high doses of antihistamines (AHs)...
  46. ncbi Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria
    Thomas Gentinetta
    Department of Rheumatology, Clinical Immunology and Allergology, Inselspital, University Bern, Bern, Switzerland
    J Allergy Clin Immunol 128:1227-1234.e5. 2011
    ..FcεRI or IgE itself, as well as other autoreactive serum components, in patients with chronic spontaneous urticaria (CU)...
  47. ncbi A functional promoter polymorphism of the human IL18 gene is associated with aspirin-induced urticaria
    S H Kim
    Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Youngtonggu, Suwon 442 721, Korea
    Br J Dermatol 165:976-84. 2011
    b>Urticaria is the commonest cutaneous reaction caused by aspirin or other nonsteroidal anti-inflammatory drugs...
  48. ncbi Peltier effect-based temperature challenge: an improved method for diagnosing cold urticaria
    Frank Siebenhaar
    J Allergy Clin Immunol 114:1224-5. 2004
  49. ncbi Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity
    Ruth A Sabroe
    St John s Institute of Dermatology and the Department of Obstetrics and Gynaecology, Guy s, King s and St Thomas School of Medicine, King s College London, St Thomas Hospital, London
    J Allergy Clin Immunol 110:492-9. 2002
    Circulating autoantibodies against FcepsilonRI, IgE, or both occur in approximately one third of patients with chronic idiopathic urticaria (CIU), but not all autoantibodies initiate histamine release.
  50. ncbi Comparative inhibition by bilastine and cetirizine of histamine-induced wheal and flare responses in humans
    Martin K Church
    Department of Dermatology and Allergy, Allergy Centre Charité, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Inflamm Res 60:1107-12. 2011
    ..Comparison of bilastine and cetirizine in inhibiting skin wheal and flare responses over 24 h...
  51. ncbi Sex hormones and urticaria
    A Kasperska-Zajac
    Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland
    J Dermatol Sci 52:79-86. 2008
    Chronic urticaria is characterized by mast cells/basophils activation which initiate the inflammatory response. Pathogenetically, the disease may in many cases represent an autoimmune phenomenon...
  52. ncbi High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria
    Petra Staubach
    Department of Dermatology, University Medical Center Mainz, Germany
    Acta Derm Venereol 91:557-61. 2011
    Quality of life, which is impaired in patients with chronic spontaneous urticaria (CSU), is influenced by comorbid mental disorders...
  53. ncbi Matrix metalloproteinase-9: a novel biomarker for monitoring disease activity in patients with chronic urticaria patients?
    S Altrichter
    Department of Dermatology and Allergy, Allergie Centrum Charité ECARF, Charite Universitatsmedizin Berlin, Germany
    Allergy 64:652-6. 2009
    ..has recently been suggested to be a good biomarker for monitoring disease activity in patients with chronic urticaria (CU)...
  54. ncbi Chronic spontaneous urticaria in children: itching for insight
    Martin K Church
    Department of Dermatology and Allergy, Charite, Universitatsmedizin Berlin, Chariteplatz 1, Germany
    Pediatr Allergy Immunol 22:1-8. 2011
    While there is increasing information about the pathogenesis and treatment of chronic spontaneous urticaria (csU) in adults, there is little published information about csU in children...
  55. ncbi Significant correlation between the CD63 assay and the histamine release assay in chronic urticaria
    A Szegedi
    Department of Dermatology, Medical and Health Science Centre, University of Debrecen, 98 Nagyerdei Str, Debrecen 4012, Hungary
    Br J Dermatol 155:67-75. 2006
    ..receptor and the IgE molecule are proposed to be of pathogenetic relevance in a group of patients with chronic urticaria (CU)...
  56. ncbi Bilastine: in allergic rhinitis and urticaria
    Natalie J Carter
    Adis, Auckland, New Zealand
    Drugs 72:1257-69. 2012
    ..antihistamine used in the symptomatic treatment of seasonal or perennial allergic rhinoconjunctivitis and urticaria. In two well designed phase III trials, 14 days' treatment with bilastine was associated with a significantly ..
  57. ncbi Clinical and laboratory examinations in the subgroups of chronic urticaria
    Beatrix Irinyi
    Department of Dermatology, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
    Int Arch Allergy Immunol 144:217-25. 2007
    The aetiology of chronic urticaria is heterogeneous. Physical urticaria (PU) is estimated at around 35%, autoimmune urticaria (AIU) at 25% and chronic idiopathic urticaria (CIU) at 35% of all chronic urticaria cases.
  58. ncbi Failure of omalizumab in cholinergic urticaria
    R A Sabroe
    Department of Dermatology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK
    Clin Exp Dermatol 35:e127-9. 2010
    Cholinergic urticaria is one of the more common physical urticarias. Although it is often fairly mild, severe treatment-resistant disease may occur, with significant associated disability...
  59. ncbi Dermatitis herpetiformis presenting as chronic urticaria
    Gavin R Powell
    Department of Dermatology, University of Colorado Health Sciences Center, Aurora, Colorado 80045 0510, USA
    Pediatr Dermatol 21:564-7. 2004
    ..We report an 11-year-old boy with an unusual presentation of DH characterized by a 7-month history of chronic urticaria-like skin lesions...
  60. ncbi High prevalence of autoimmune urticaria in children with chronic urticaria
    Luigia Brunetti
    Department of Biomedicina dell Eta Evolutiva, University of Bari, Italy
    J Allergy Clin Immunol 114:922-7. 2004
    The etiology of chronic urticaria (CU) in childhood often remains unrecognized. Recently, in adults it has been shown that approximately 40% of patients with CU have autoimmune urticaria (AU); however, no data are available in children.
  61. ncbi Rapid effects of olopatadine hydrochloride on the histamine-induced skin responses
    Keisuke Morita
    Department of Dermatology, Graduate School of Medical Sciences, Fukuoka, Japan
    J Dermatol 29:709-12. 2002
    ..is one of the second-generation nonsedating antihistamines that are used for treating allergic disorders such as urticaria, rhinitis, and atopic dermatitis...
  62. ncbi Cryopyrin-associated periodic syndrome: an autoinflammatory disease manifested as neutrophilic urticarial dermatosis with additional perieccrine involvement
    Athanassios Kolivras
    Department of Dermatology and Dermatopathology, Brugmann, HUDERF and Saint Pierre Hospitals, Universite Libre de Bruxelles, Brussels, Belgium
    J Cutan Pathol 38:202-8. 2011
    ..NUD with perieccrine involvement should prompt consideration of CAPS, especially NOMID, in the context of neonatal multisystem disease...
  63. ncbi A case of severe refractory chronic urticaria: a novel method for evaluation and treatment
    Hans F Otto
    Department of Allergy and Immunology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas, USA
    Allergy Asthma Proc 30:333-7. 2009
    With cholinergic urticaria (ChU), the ultimate diagnosis often depends on the demonstration of characteristic urticaria by appropriate provocation...
  64. ncbi [Autoreactive urticaria and autoimmune urticaria]
    M Maurer
    Zentrum für Immundermatologie, Universitäts Hautklink Mainz, Langenbeckstrasse 1, 55131 Mainz
    Hautarzt 55:350-6. 2004
    Symptoms in patients with autoreactive urticaria (ArU), a sub-form of chronic urticaria (CU), are caused by circulating histamine-releasing signals...
  65. ncbi Serum-induced basophil CD63 expression by means of a tricolour flow cytometric method for the in vitro diagnosis of chronic urticaria
    A Frezzolini
    Laboratory of Immunology and Allergology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    Allergy 61:1071-7. 2006
    ..the alpha-chain of the high-affinity IgE receptor (FcepsilonRIalpha) identify a subset of patients with chronic urticaria (CU) due to autoreactivity, as assessed by an in vivo positive response to autologous serum skin test (ASST)...
  66. pmc Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose
    Scott P Commins
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA, USA
    J Allergy Clin Immunol 123:426-33. 2009
    ..Recent work, however, has shown that IgE antibodies to galactose-alpha-1,3-galactose (alpha-gal), a carbohydrate commonly expressed on nonprimate mammalian proteins, are capable of eliciting serious, even fatal, reactions...
  67. ncbi Stress, psychiatric co-morbidity and coping in patients with chronic idiopathic urticaria
    Man Cheung Chung
    Clinical Psychology Teaching Unit, Peninsula Allied Health Centre, University of Plymouth, Plymouth, PL6 8BH, UK
    Psychol Health 25:477-90. 2010
    ..examined life event stress, perceived stress and psychiatric co-morbidity among patients with Chronic Idiopathic Urticaria (CIU)...
  68. ncbi Urticarial lesions: if not urticaria, what else? The differential diagnosis of urticaria: part II. Systemic diseases
    Anna Peroni
    Department of Biomedical and Surgical Sciences, Section of Dermatology and Venereology, University of Verona, Verona, Italy
    J Am Acad Dermatol 62:557-70; quiz 571-2. 2010
    ..All of these conditions may enter into the differential diagnosis of ordinary urticaria. In contrast to urticaria, urticarial syndromes may manifest with skin lesions other than wheals, such as ..
  69. ncbi Cholinergic urticaria: pathogenesis-based categorization and its treatment options
    S Nakamizo
    Department of Dermatology, Kyoto University, Kyoto, Japan
    J Eur Acad Dermatol Venereol 26:114-6. 2012
    Cholinergic urticaria (CU) has well-described characteristic clinical presentations, yet the precise pathological mechanism remains incompletely understood...
  70. ncbi NSAID-induced urticaria and angioedema: a reappraisal of its clinical management
    Mario Sanchez-Borges
    Allergy Immunology Service, Centro Medico Docente La Trinidad, Caracas, Venezuela
    Am J Clin Dermatol 3:599-607. 2002
    Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs), resulting in urticaria and angioedema, is being observed with increasing frequency. Prevalence rates range from 0.1-0...
  71. ncbi Association of thromboxane A2 receptor (TBXA2R) gene polymorphism in patients with aspirin-intolerant acute urticaria
    N S Palikhe
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, South Korea
    Clin Exp Allergy 41:179-85. 2011
    ..This study evaluated the association between genetic TBXA2R variants and the development of acetyl salicylic acid (ASA)-intolerant acute urticaria (AIAU).
  72. ncbi Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria
    Martin Metz
    Department of Dermatology and Allergy, Allergie Centrum Charité, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int Arch Allergy Immunol 154:177-80. 2011
    In physical urticaria, exogenous physical factors such as thermal triggers, solar radiation and mechanic triggers including friction or pressure are responsible for the elicitation of symptoms in the skin of patients...
  73. ncbi Polymorphisms of cyclo-oxygenases and 5-lipo-oxygenase-activating protein are associated with chronic spontaneous urticaria and urinary leukotriene E4
    Gabriele Di Lorenzo
    Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita di Palermo, Palermo, Italy
    Eur J Dermatol 21:47-52. 2011
    The mechanisms of chronic spontaneous urticaria (CSU) continue to be unknown. Our working hypothesis is that polymorphisms of cyclo-oxygenases and 5-lipo-oxygenase-activating protein may be involved in the pathways leading to CSU...
  74. ncbi Acupuncture treatment of urticaria
    C J Chen
    Department of Internal Medicine, Kaohsiung Medical College, Taiwan
    Arch Dermatol 134:1397-9. 1998
    Acupuncture has long been used to treat urticaria in the Asian world. Acute urticaria can be easily and effectively treated with acupuncture...
  75. ncbi Evidence-based guidelines for the prevention, identification and management of occupational contact dermatitis and urticaria
    Paul J Nicholson
    Procter and Gamble, Whitehall Lane, Egham, Surrey, UK
    Contact Dermatitis 63:177-86. 2010
    ..A systematic review was commissioned by the British Occupational Health Research Foundation in response to a House of Lords Science and Technology Committee recommendation...
  76. ncbi Role of stressful life events in induction or exacerbation of psoriasis and chronic urticaria
    S K Malhotra
    Department of Dermatology, Venereology and Leprology, GGS Medical College and Hospital, Faridkot Punjab, India
    Indian J Dermatol Venereol Leprol 74:594-9. 2008
    ..Previous reports addressing its influence on skin psoriasis and chronic urticaria have been mainly anecdotal.
  77. ncbi Stress, insomnia, and chronic idiopathic urticaria--a case-control study
    Hsiao Yu Yang
    Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Formos Med Assoc 104:254-63. 2005
    There is growing evidence that stress might play a crucial role in the pathogenesis of urticaria. This study examined the association between chronic idiopathic urticaria and stress from major life events and explored the validity of the ..
  78. ncbi Update on chronic urticaria: focusing on mechanisms
    Agnieszka Młynek
    Psychodermatology Department, Chair of Dermatology and Venereology, Medical University of Łódź, Łódź, Poland
    Curr Opin Allergy Clin Immunol 8:433-7. 2008
    This review discusses some of the recent advances in basic and clinical research focused on chronic urticaria. It is a concise summary of issues that occupied researchers' attention in the previous year, and it discusses a selection of ..
  79. ncbi Quality of life in patients with urticaria
    David R Weldon
    Department of Allergy and Pulmonary Services, Scott and White Clinic, College Station, Texas A and M University Health Sciences Center, TX 77840, USA
    Allergy Asthma Proc 27:96-9. 2006
    Patients with chronic urticaria have a poor quality of life (QOL). Chronic pruritus with variable appearance of urticaria and/or angioedema are typical of the uncertainty that compromise their QOL...
  80. ncbi Physical urticaria
    John P Dice
    Department of Allergy and Immunology, Wilford Hall Medical Center, Lackland Air Force Base, 2200 Bergquist Drive, Suite 1, San Antonio, TX 78236, USA
    Immunol Allergy Clin North Am 24:225-46, vi. 2004
    Physical urticarias are a unique subgroup of chronic urticaria in which patients develop urticaria secondary to environmental stimuli...
  81. ncbi Comparative study of the impact of chronic urticaria, psoriasis and atopic dermatitis on the quality of life
    J J Grob
    Service de Dermatologie, Hopital Henri Mondor, Creteil, France
    Br J Dermatol 152:289-95. 2005
    ..A better management of chronic skin disorders (CSDs) requires a knowledge of their impact from the patient's point of view...
  82. ncbi The use of a responder analysis to identify clinically meaningful differences in chronic urticaria patients following placebo- controlled treatment with rupatadine 10 and 20 mg
    A Gimenez-Arnau
    Servicio de Dermatologia, Hospital del Mar, IMAS, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Eur Acad Dermatol Venereol 23:1088-91. 2009
    According to the EAACI/GA(2)LEN/EDF guidelines for urticaria management, modern non-sedating H1-antihistamines are the first-line symptomatic treatment for chronic urticaria...
  83. ncbi Rupatadine in allergic rhinitis and chronic urticaria
    J Mullol
    Unitat de Rinologia, Servei d ORL, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Allergy 63:5-28. 2008
    Histamine is the primary mediator involved the pathophysiology of allergic rhinitis and chronic urticaria, and this explains the prominent role that histamine H(1)-receptor antagonists have in the treatment of these disorders...
  84. ncbi Decline in dehydroepiandrosterone sulfate observed in chronic urticaria is associated with psychological distress
    Zenon Brzoza
    Clinical Department of Internal Diseases, Allergology and Clinical Immunology in Zabrze, Medical University of Silesia in Katowice, ul 3 Maja 13 15, 41 800 Zabrze, Poland
    Psychosom Med 70:723-8. 2008
    Dehydroepiandrosterone sulfate (DHEA-S) decline in chronic urticaria (CU) may be involved in etiopathogenesis of the disease or is a secondary phenomenon resulting e.g. from psychological distress...
  85. ncbi Angioedema
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    J Am Acad Dermatol 53:373-88; quiz 389-92. 2005
    ..category, allergic and nonsteroidal anti-inflammatory drug-induced angioedema are frequently accompanied by urticaria. Idiopathic chronic angioedema is also usually accompanied by urticaria, but can occur without hives...
  86. ncbi EAACI/GA2LEN/EDF guideline: definition, classification and diagnosis of urticaria
    T Zuberbier
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Allergy 61:316-20. 2006
    ..is the result of a consensus reached during a panel discussion at the 2nd International Consensus Meeting on Urticaria, Urticaria 2004, a joint initiative of the European Academy of Allergology and Clinical Immunology Dermatology ..
  87. ncbi The natural history of chronic urticaria and angioedema in patients visiting a tertiary referral centre
    P G M Van Der Valk
    Department of Dermatology, University Medical Centre St Radboud, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 146:110-3. 2002
    Data on the natural history and prognostic variables of chronic urticaria and its subtypes are scarce.
  88. ncbi Chronic urticaria
    Clive E H Grattan
    Dermatology Centre, Norfolk and Norwich University Hospital, Norwich, UK
    J Am Acad Dermatol 46:645-57; quiz 657-60. 2002
    Chronic urticaria has a spectrum of clinical presentations and causes. About 50% of patients with "idiopathic" disease have histamine-releasing autoantibodies in their blood...
  89. ncbi Guidelines for evaluation and management of urticaria in adults and children
    C E H Grattan
    Department of Dermatology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, UK
    Br J Dermatol 157:1116-23. 2007
    Appropriate management of urticaria depends on the correct evaluation of clinical patterns and causes where these can be identified...
  90. ncbi Chronic urticaria: pathogenesis and treatment
    Allen P Kaplan
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC 92425, USA
    J Allergy Clin Immunol 114:465-74; quiz 475. 2004
    Patients previously designated as having chronic idiopathic urticaria are now divided into 2 groups: 40% to 50% with chronic autoimmune urticaria, and the remainder with chronic idiopathic urticaria...
  91. ncbi Serum concentration of dehydroepiandrosterone sulphate in female patients with chronic idiopathic urticaria
    Alicja Kasperska-Zajac
    J Dermatol Sci 41:80-1. 2006
  92. ncbi Chronic idiopathic and chronic autoimmune urticaria: clinical and immunopathological features of 68 subjects
    Marzia Caproni
    Department of Dermatological Sciences, II Dermatological Clinic, University of Florence, Florence, Italy
    Acta Derm Venereol 84:288-90. 2004
    ..tests with autologous serum elicit an immediate wheal-and-flare response in about 30-50% of chronic idiopathic urticaria subjects, suggesting that an autoimmune mechanism might be involved in the pathogenesis of this disease...
  93. ncbi Acquired cold urticaria: clinical picture and update on diagnosis and treatment
    F Siebenhaar
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Clin Exp Dermatol 32:241-5. 2007
    Acquired cold urticaria (ACU) is a frequent subtype of physical urticaria that is caused by the release of proinflammatory mast cell mediators after cold exposure...
  94. ncbi Evaluation of the antihistamine effects of olopatadine, cetirizine and fexofenadine during a 24 h period: a double-blind, randomized, crossover, placebo-controlled comparison in skin responses induced by histamine iontophoresis
    Hitoshi Takahashi
    Department of Dermatology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan
    Arch Dermatol Res 300:291-5. 2008
    ..These results demonstrate that olopatadine is the most potent antihistamine among the three H(1)-blockers when administered in a standard dosage...
  95. ncbi House dust mite sensitivity is a factor in chronic urticaria
    P A Mahesh
    Department of Pulmonology, JSS Medical College, Mysore, India
    Indian J Dermatol Venereol Leprol 71:99-101. 2005
    Chronic urticaria is one of the perplexing problems faced by clinicians...
  96. ncbi Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic idiopathic urticaria
    Alicja Kasperska-Zajac
    Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, ul 3 go Maja 13 15, 41 800 Zabrze, Medical University of Silesia, Katowice, Poland
    Cytokine 39:142-6. 2007
    Decline in circulating DHEA-S concentration may be a phenomenon accompanying chronic idiopathic urticaria (CIU). IL-6 is a multifunctional proinflammatory cytokine which exerts a wide range of biological effects...
  97. ncbi Anisakis simplex sensitization-associated urticaria: short-lived immediate type or prolonged acute urticaria
    Alvaro Daschner
    Hospital Universitario de la Princesa, Madrid, Spain
    Arch Dermatol Res 302:625-9. 2010
    Acute urticaria is defined as evanescent wheals with a duration period of up to 6 weeks...
  98. ncbi The relationship between posttraumatic stress disorder, psychiatric comorbidity, and personality traits among patients with chronic idiopathic urticaria
    Man Cheung Chung
    University of Plymouth, Clinical Psychology Teaching Unit, Peninsula Allied Health Centre, PL6 8BH, United Kingdom
    Compr Psychiatry 51:55-63. 2010
    ..No empirical studies, however, have investigated the relationship between PTSD and chronic idiopathic urticaria (CIU). The role of personality traits in this relationship was also unknown.
  99. doi Successful treatment of cholinergic urticaria with anti-immunoglobulin E therapy
    M Metz
    Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Chariteplatz, Berlin, Germany
    Allergy 63:247-9. 2008
  100. ncbi Urticaria : a review
    Tasneem Poonawalla
    University of Texas Medical Branch, Galveston, Texas, USA
    Am J Clin Dermatol 10:9-21. 2009
    b>Urticaria is often classified as acute, chronic, or physical based on duration of symptoms and the presence or absence of inducing stimuli...
  101. ncbi Chronic urticaria caused by Hymenolepis nana in an adopted girl
    G L Marseglia
    Dipartimento di Scienze Pediatriche Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 2, 27100 Pavia, Italy
    Allergy 62:821-2. 2007

Research Grants51

  1. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..including TNF-alpha receptor associated periodic syndrome (TRAPS), Muckle-Wells syndrome, familial cold urticaria (FCAS), and hyper- immunoglobulin D syndrome...
  2. Complement protein synthesis and activation by human mast cells
    Yoshihiro Fukuoka; Fiscal Year: 2010
    ..for disorders in which both complement and mast cells are activated, such as asthma and chronic autoimmune urticaria. PUBLIC HEALTH RELEVANCE: Asthma is a major problem in the United States and also in the world...
  3. IgE to carbohydrates causes delayed anaphylaxis
    SCOTT PALMER COMMINS; Fiscal Year: 2013
    ..Patients who have IgE antibodies to alpha-gal report delayed anaphylaxis or urticaria occurring 3-6 hours after eating beef, pork or lamb...
  4. Human Basophil Phenotypes and Therapeutic Outcomes
    Donald W Macglashan; Fiscal Year: 2013
    ..associated with food allergies and severe asthma and the suppressed phenotype associated with chronic idiopathic urticaria. It is expected that identification of the basis for the phenotypes will provide new insights into the ..
  5. PATHOGENESIS OF ALLERGIC DISEASES OF THE SKIN & LUNGS
    Allen Kaplan; Fiscal Year: 1992
    ..mechanisms of tissue injury in a wide variety of diseases to include physically induced hives, chronic urticaria and angioedema, hereditary angioedema, Lyme disease, cryoglobulinemia (and other vasculitides) and asthma...
  6. Identification of Dysregulated Stress Response Mechanisms in Chronic Urticaria
    Marcia J Slattery; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic urticaria (CU) is a common, debilitating, relapsing dermatological disorder characterized by daily hives for at least 6 weeks, and in many individuals, lasting over 20 years...
  7. OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSING
    Thomas Robins; Fiscal Year: 2001
    ..A second aim is to determine the prevalence of allergic sensitization and health outcomes (rhino-conjunctivitis, urticaria/dermatitis and asthma) due to processing of rock lobster and saltwater bony fish through subject interviews, ..
  8. ASTHMA--ALLERGY AND AUTOIMMUNITY
    ENG TAN; Fiscal Year: 1990
    ..The fourth project will study activation of the contact system in angioedema and urticaria, including acquired C1 inhibitor deficiency where a degradation product of C1inh has been shown to be a unique ..
  9. EVALUATION OF BASOPHIL INVOLVEMENT IN HUMAN DISEASE
    Lawrence Schwartz; Fiscal Year: 2001
    ..basophils will be examined in human tissues using the 2D7 mAb, including skin in atopic dermatitis, chronic urticaria, and urticaria pigmentosa, nasal mucosa in allergic rhinitis and lung in asthma...
  10. HUMAN SKIN MAST CELL GRANULE ENZYMES--SKIN DISEASES
    BRUCE WINTROUB; Fiscal Year: 1992
    ..Finally, the deposition of mast cell granule carboxypeptidase will be examined in vivo in diseases marked by increased vascular permeability, i.e. cold urticaria, and by tissue destruction, i.e. bullous pemphigoid.
  11. TMEM103 in Eosinophil Development
    LORI A contact WAGNER; Fiscal Year: 2010
    ..are associated with many allergic diseases including asthma, atopic dermatitis, drug reactions and chronic urticaria. The myriad of eosinophil related diseases has led us to investigate the development of eosinophils from ..
  12. INTERDISCIPLINARY RESEARCH IN IMMUNOLOGIC DISEASES
    Phillip Norman; Fiscal Year: 1990
    ..Mediator release in inflammatory bowel disease, 2. Proteases in bullous pemphigoid and chronic urticaria, 3. Mechanisms of anti-inflammatory actions of corticosteroids, 4...
  13. PROTEINASES AND MEDIATORS IN CUTANEOUS BIOLOGY
    ROBERT LAVKER; Fiscal Year: 1993
    ..Special consideration will be given to: psoriasis, pemphigus, urticaria pigmentosum and diseases with evidence of mast cell activation...
  14. ASTHMA & ALLERGIC DISEASE CENTER FOR IMMUNODERMATOLOGY
    IRMA GIGLI; Fiscal Year: 1990
    ..The center will concentrate in studies of: 1. Diseases within the spectrum of cutaneous vasculitis-angioedema-urticaria. In these studies we will attempt to identify the biochemical mediators and cellular interactions that may be ..
  15. GENETIC AND MOLECULAR BASIS OF FAMILIAL COLD URTICARIA
    Harold Hoffman; Fiscal Year: 2002
    ..term objective of this project is the localization and identification of the gene responsible for familial cold urticaria. Familial cold urticaria is an excellent example of the immune system's response to physical stimuli in the ..
  16. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  17. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  18. MECHANISMS OF IGE REGULATION OF HUMAN LEUKOCYTES
    Sarbjit Saini; Fiscal Year: 2003
    ..The results of the planned studies will further define mechanisms of FcepsilonRI regulation on basophils and monocytes, and may lead to novel FcepsilonRI-based strategies for the treatment of allergic diseases. ..
  19. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. [unreadable] [unreadable] [unreadable]..
  20. Novel regulatory role of cryopyrin in inflammation
    Harold Hoffman; Fiscal Year: 2005
    ..abstract_text> ..
  21. Pimecrolius on T cell Responses in Atopic March
    Jonathan Spergel; Fiscal Year: 2008
    ..In third aim of the trial, we explore the effects of pimecrolimus as a disease-modifying agent in the prevention of asthma. Asthma phenotype will be examined by spirometry per and post-beta-2-agonist and exhaled nitric oxide. ..
  22. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
    ..We will estimate the incremental cost-effectiveness of PS. ..
  23. GILZ Controls TLR-Induced NF-kB Activity In Acute Asthma
    Bruce Zuraw; Fiscal Year: 2008
    ..We anticipate that this proposal will provide novel and clinically relevant data regarding the mechanisms of acute asthma exacerbations. ..
  24. CysLt and P2Y Receptors and Lung Inflammation
    Joshua Boyce; Fiscal Year: 2007
    ..abstract_text> ..
  25. Src Family Kinase Regulation in Allergy
    Becky Vonakis; Fiscal Year: 2007
    ..Understanding the molecular details of the interaction of Src family kinases with FceRI may allow the development of drugs that will limit allergic reactions rather than mitigating symptoms. ..
  26. REPRESSORS OF HUMAN AND GLOBIN GENE EXPRESSION
    Deborah Gumucio; Fiscal Year: 2001
    ..This should provide a valuable tool for the further dissection of the regulators of hemoglobin switching. ..
  27. Outcomes of Omission of Radiation With Lumpectomy (BCS) Among Low-Income Women
    Roger Anderson; Fiscal Year: 2007
    ..abstract_text> ..
  28. Mechanism of IgE Mediated FceRI Regulation
    Jean Pierre Kinet; Fiscal Year: 2001
    ..Taken together, these analyses will provide significant insights into the process and molecular parameters that control the IgE-mediated regulation of FceRI expression. ..
  29. Mechanisms of FcR-Mediated Inflammatory Responses
    Jean Pierre Kinet; Fiscal Year: 2009
    ..Moreover, they will provide the proof of concept for the therapeutic use of these antibodies in the context of MC-associated diseases. ..
  30. TGF-BETA, CHLORIDE CHANNELS AND APOPTOSIS OF AIRWAY EPITHELIAL CELLS
    Devendra K Agrawal; Fiscal Year: 2010
    ..Such investigations would provide unique insights to the pathophysiologic process of chronic asthma and the means to prevent or reverse the disease. ..
  31. FLT3-LIGAND, IMMUNOMODULATION AND THERAPY IN ASTHMA
    DEVENDRA AGRAWAL; Fiscal Year: 2008
    ..The long-term goal of this study is to better define the potential mechanisms of action of FL to prevent and reverse allergic airway inflammation and associated changes in pulmonary function. ..
  32. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  33. INDUCTION OF ATHEROGENESIS BY COCAINE AND HIV INFECTION
    Guha Krishnaswamy; Fiscal Year: 2001
    ..abstract_text> ..
  34. A cellular key to the gastric inflammation-metaplasia-carcinoma sequence?
    Deborah Gumucio; Fiscal Year: 2008
    ..Moreover, if it is demonstrated that tumors indeed arise from pGPC, this will have enormous implications for the further study and future clinical management of gastric cancer. [unreadable] [unreadable] [unreadable]..
  35. Calcium influx pathways in lymphocytes and mast cells
    Jean Pierre Kinet; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  36. DOPAMINE AND PLASTICITY IN RESPIRATORY CONTROL
    Rebecca Johnson; Fiscal Year: 2002
    ..End of Abstract) ..
  37. RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    Bruce Zuraw; Fiscal Year: 2002
    ..These results will provide a necessary foundation for additional investigations into downstream inflammatory consequences of rhinovirus infection as well as potential targets for new intervention strategies. ..
  38. CONTROL OF THE GAMMA TO BETA GLOBIN SWITCH
    Deborah Gumucio; Fiscal Year: 2003
    ..This comparative functional analysis of primate globin genes in transgenic mice, combined with studies in extant primates will provide new insights into mechanisms of hemoglobin switching. ..
  39. Lyn Kinase Regulation of FceRI-induced Mediator Release
    Becky Vonakis; Fiscal Year: 2003
    ..Understanding the molecular details of the interaction of the Lyn unique domain and FcERI beta(Fc) may allow the development of drugs that will inhibit allergic reactions rather than mitigating their symptoms. ..
  40. Bioreactivity Markers in Total Hip Replacments
    Nadim Hallab; Fiscal Year: 2004
    ..Additionally, variable immunologic responses induced by implant degradation products (i.e. lymphocyte response to metal ions and monocyte/macrophage response to particulate debris) will be correlated with the development of osteolysis ..
  41. INHALED STEROID ADHERENCE IN MODERATE & SEVERE ASTHMA
    Andrea Apter; Fiscal Year: 2004
    ..Upon the foundation of my prior clinical experience and education, this training program is designed to equip me with the additional skills and research experience necessary to become a fully independent investigator. ..
  42. Cardiovascular Chemoreflex-Baroreflex Interaction
    JOHN HALLIWILL; Fiscal Year: 2005
    ..By addressing these aims, we will extend insights that are now only available in animals to a poorly understood area of cardiovascular regulation in humans. ..
  43. Lyn Kinase-Mediated Regulation of Allergic Inflammation
    Becky Vonakis; Fiscal Year: 2005
    ..Understanding the molecular details of the interaction of the Lyn unique domain and FceRI beta may allow the development of drugs that will limit allergic reactions rather than mitigating symptoms. ..
  44. Role of the IgE-FceRI network in allergic inflammation
    Jean Pierre Kinet; Fiscal Year: 2005
    ..abstract_text> ..
  45. Visual outcomes & quality of life in CMV retinitis
    Jennifer Thorne; Fiscal Year: 2006
    ..abstract_text> ..
  46. The Role of Mast Cells in Lung Inflammation
    Joshua Boyce; Fiscal Year: 2006
    ..These studies, carried out in non-transformed hPrMC and hMC, have potential implications for the control of hMC distribution and effector function in asthma. ..
  47. Molecular Etiology of Familial Mediterranean Fever
    Deborah Gumucio; Fiscal Year: 2007
    ..family members have already been connected to several human diseases, including inflammatory bowel disease, PAPA syndrome, Muckle-Wells sydrome, familial cold urticaria, Blau syndrome and Be_het's disease.
  48. Periodontal Assessment in RA Study (PARAS)
    Clifton Bingham; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  49. MOLECULAR ANALYSIS OF FCERI SIGNALING AND FUNCTION
    Jean Pierre Kinet; Fiscal Year: 2003
    ..He will investigate 1) whether there are differences between individuals in the betaWT/betaT ratio, and 2) whether these differences correlate with allergic status. ..