leg ulcer

Summary

Summary: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.

Top Publications

  1. ncbi Prevalence of leg ulceration in a London population
    C J Moffatt
    Centre for Research and Implementation of Clinical Practice, Thames Valley University, London, UK
    QJM 97:431-7. 2004
  2. ncbi Multiple bacterial species reside in chronic wounds: a longitudinal study
    Kristine Gjødsbøl
    Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
    Int Wound J 3:225-31. 2006
  3. ncbi Venous incompetence, poverty and lactate dehydrogenase in Jamaica are important predictors of leg ulceration in sickle cell anaemia
    V Cumming
    Sickle Cell Unit, Tropical Medicine Research Institute, University of the West Indies, Kingston, Jamaica, West Indies
    Br J Haematol 142:119-25. 2008
  4. ncbi Risk factors associated with the failure of a venous leg ulcer to heal
    D J Margolis
    Department of Dermatology, Center for Clinical Epidemiology, and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Dermatol 135:920-6. 1999
  5. ncbi Prevalence of lower-limb ulceration: a systematic review of prevalence studies
    Ian D Graham
    School of Nursing, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    Adv Skin Wound Care 16:305-16. 2003
  6. ncbi Factors associated with recurrence of venous leg ulcers: a survey and retrospective chart review
    Kathleen Finlayson
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Queensland 4059, Australia
    Int J Nurs Stud 46:1071-8. 2009
  7. pmc Cost effectiveness of community leg ulcer clinics: randomised controlled trial
    C J Morrell
    School of Health and Related Research ScHARR, University of Sheffield, Sheffield S1 4DA
    BMJ 316:1487-91. 1998
  8. ncbi Leg ulcer point prevalence can be decreased by broad-scale intervention: a follow-up cross-sectional study of a defined geographical population
    Alexandra Forssgren
    Department of Dermatology, Skaraborg Hospital KSS, Skovde, Sweden
    Acta Derm Venereol 88:252-6. 2008
  9. pmc Blood viscosity and the expression of inflammatory and adhesion markers in homozygous sickle cell disease subjects with chronic leg ulcers
    Andre S Bowers
    Department of Basic Medical Sciences, Physiology Section, University of the West Indies, Mona, Kingston 7, Jamaica
    PLoS ONE 8:e68929. 2013
  10. ncbi Skin iron deposition characterises lipodermatosclerosis and leg ulcer
    A Caggiati
    Department of Anatomy, Sapienza University of Rome, Italy
    Eur J Vasc Endovasc Surg 40:777-82. 2010

Research Grants

Detail Information

Publications284 found, 100 shown here

  1. ncbi Prevalence of leg ulceration in a London population
    C J Moffatt
    Centre for Research and Implementation of Clinical Practice, Thames Valley University, London, UK
    QJM 97:431-7. 2004
    ..Aim: To determine the prevalence and cause of leg ulceration in a defined geographical population after 8 years of providing standardized evidence based protocols of care...
  2. ncbi Multiple bacterial species reside in chronic wounds: a longitudinal study
    Kristine Gjødsbøl
    Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
    Int Wound J 3:225-31. 2006
    ..Our results suggest that the presence of P. aeruginosa in venous leg ulcers can induce ulcer enlargement and/or cause delayed healing...
  3. ncbi Venous incompetence, poverty and lactate dehydrogenase in Jamaica are important predictors of leg ulceration in sickle cell anaemia
    V Cumming
    Sickle Cell Unit, Tropical Medicine Research Institute, University of the West Indies, Kingston, Jamaica, West Indies
    Br J Haematol 142:119-25. 2008
    ..5% and cumulative incidence 16.7%. Gender or alpha-thalassaemia trait did not affect the incidence of leg ulcer. Ulceration was associated with lower haemoglobin, red cell count, fetal haemoglobin, and socio-economic status ..
  4. ncbi Risk factors associated with the failure of a venous leg ulcer to heal
    D J Margolis
    Department of Dermatology, Center for Clinical Epidemiology, and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Arch Dermatol 135:920-6. 1999
    ..Venous leg ulcers afflict a significant portion of the population. The most popular form of therapy for venous leg ulcers is a compression bandage (eg, Unna boot), a therapy that is frequently unsuccessful...
  5. ncbi Prevalence of lower-limb ulceration: a systematic review of prevalence studies
    Ian D Graham
    School of Nursing, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
    Adv Skin Wound Care 16:305-16. 2003
    ..To determine the prevalence of leg ulcers reported in the literature...
  6. ncbi Factors associated with recurrence of venous leg ulcers: a survey and retrospective chart review
    Kathleen Finlayson
    Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, Queensland 4059, Australia
    Int J Nurs Stud 46:1071-8. 2009
    ..Chronic venous leg ulcers have a significant impact on older individuals' well-being and health care resources. Unfortunately after healing, up to 70% recur...
  7. pmc Cost effectiveness of community leg ulcer clinics: randomised controlled trial
    C J Morrell
    School of Health and Related Research ScHARR, University of Sheffield, Sheffield S1 4DA
    BMJ 316:1487-91. 1998
    To establish the relative cost effectiveness of community leg ulcer clinics that use four layer compression bandaging versus usual care provided by district nurses.
  8. ncbi Leg ulcer point prevalence can be decreased by broad-scale intervention: a follow-up cross-sectional study of a defined geographical population
    Alexandra Forssgren
    Department of Dermatology, Skaraborg Hospital KSS, Skovde, Sweden
    Acta Derm Venereol 88:252-6. 2008
    In 1988 a cross-sectional epidemiological study was performed in Skaraborg County, Sweden, establishing leg ulcer point prevalence...
  9. pmc Blood viscosity and the expression of inflammatory and adhesion markers in homozygous sickle cell disease subjects with chronic leg ulcers
    Andre S Bowers
    Department of Basic Medical Sciences, Physiology Section, University of the West Indies, Mona, Kingston 7, Jamaica
    PLoS ONE 8:e68929. 2013
    ....
  10. ncbi Skin iron deposition characterises lipodermatosclerosis and leg ulcer
    A Caggiati
    Department of Anatomy, Sapienza University of Rome, Italy
    Eur J Vasc Endovasc Surg 40:777-82. 2010
    ..Despite increasing interest in the role of haemosiderin in venous ulceration, no study has systematically evaluated the occurrence of iron overload in the limbs of patients with CVD...
  11. ncbi Natural history of limbs with arterial insufficiency and chronic ulceration treated without revascularization
    William A Marston
    Division of Vascular Surgery, Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7212, USA
    J Vasc Surg 44:108-114. 2006
    ..In this report, we describe the outcome of limbs with stable chronic leg ulcers and arterial insufficiency that were treated with wound-healing techniques in patients who were not candidates for revascularization...
  12. ncbi Causes, investigation and treatment of leg ulceration
    J R Mekkes
    Departments of Dermatology and Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Br J Dermatol 148:388-401. 2003
    ..For a proper treatment of patients with leg ulcers, it is important to be aware of the large differential diagnosis of leg ulceration...
  13. ncbi Validation of venous leg ulcer guidelines in the United States and United Kingdom
    Maryanne McGuckin
    School of Medicine, University of Pennsylvania, 422 Curie Blvd, Rm 605A, Stellar Chance Building, Philadelphia, PA 19104 6021, USA
    Am J Surg 183:132-7. 2002
    ..The purpose of this study was to validate the clinical efficacy and cost effectiveness of multidisciplinary guidelines for the diagnosis and treatment of venous leg ulcers...
  14. ncbi Are community leg ulcer clinics more cost-effective than home care visits?
    L R Patton
    South Eastern Health and Social Care Trust, Northern Ireland, UK
    J Wound Care 18:49-50, 52. 2009
    The literature suggests that leg ulcer clinics are more expensive than home visits, but are associated with faster healing times...
  15. doi Leg ulcer and bacteremia due to Cedecea davisae
    Maria Dalamaga
    Eur J Dermatol 18:204-5. 2008
  16. pmc Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
    Gregory J Kato
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1476, Bldg 10CRC, Rm 5 5140, Bethesda, MD 20892, USA
    Blood 107:2279-85. 2006
    ..We propose that LDH elevation identifies patients with a syndrome of hemolysis-associated NO resistance, endothelial dysfunction, and end-organ vasculopathy...
  17. ncbi Venous leg ulcer care: how evidence-based is nursing practice?
    Karen R Lorimer
    Ottawa Carleton Regional Leg Ulcer Project, Ottawa Health Research Institute, Ottawa, Canada
    J Wound Ostomy Continence Nurs 30:132-42. 2003
    The objectives of this study were to (1) determine how congruent community-provided leg ulcer care was with best practice for venous leg ulcers and (2) identify organizational and clinical factors associated with the provision of best ..
  18. ncbi The measurement of leg ulcer pain: identification and appraisal of pain assessment tools
    Kathleen A Nemeth
    Thrombosis Hemostasis Research Group, The Ottawa Hospital, Ottawa, Ontario, Canada
    Adv Skin Wound Care 16:260-7. 2003
    To identify and compare the psychometric, clinical sensibility, and pain-specific properties of leg ulcer pain assessment tools for use as a guide for clinicians and researchers.
  19. ncbi Venous leg ulcer patients: a review of the literature on lifestyle and pain-related interventions
    Maud M Heinen
    Quality of Care Research, Department of Nursing Science, University Medical Centre Nijmegen, St Radboud, The Netherlands
    J Clin Nurs 13:355-66. 2004
    Having a leg ulcer has a major impact on daily life. Lifestyle is mentioned in most leg ulcer guidelines but mostly without much emphasis on the subject.
  20. pmc Leg ulcers in sickle cell disease: current patterns and practices
    Kara Marie H Delaney
    National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1476, USA
    Hemoglobin 37:325-32. 2013
    ..Despite their frequency, there is no clear consensus among providers as to the best treatment. ..
  21. pmc Leg ulcers in sickle cell disease
    Caterina P Minniti
    Pulmonary Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hematol 85:831-3. 2010
    ....
  22. ncbi Why is it so hard to do the right thing in wound care?
    Caroline E Fife
    Department of Medicine, Division of Cardiology, The University of Texas Health Science Center, Houston, Texas 77030, USA
    Wound Repair Regen 18:154-8. 2010
    ....
  23. ncbi Developing a nurse-led education program to enhance self-care agency in leg ulcer patients
    Oliver R Herber
    Institute of General Practice and Family Medicine, University of Witten Herdecke, Witten, North Rhine Westphalia, Germany
    Nurs Sci Q 21:150-5. 2008
    ..Orem's self-care deficit nursing theory is used as a framework to provide the conceptual context for this supportive-educative nursing system that is being tested in a multi-site clinical trial...
  24. ncbi The Lindsay Leg Club Model: a model for evidence-based leg ulcer management
    Ellie Lindsay
    Thames Valley University, London and Queensland University of Technology
    Br J Community Nurs . 2004
    Leg Club is a unique model of community-based leg ulcer care...
  25. ncbi The Lively Legs self-management programme increased physical activity and reduced wound days in leg ulcer patients: Results from a randomized controlled trial
    Maud Heinen
    Scientific Institute for Quality of Healthcare, Radboud University Nijmegen Medical Centre, The Netherlands
    Int J Nurs Stud 49:151-61. 2012
    Investigating the effectiveness of the Lively Legs program for promoting adherence with ambulant compression therapy and physical exercise as well as effects on leg ulcer recurrence.
  26. ncbi An unusual case of nonhealing leg ulcer in a diabetic patient
    Sagar U Nigwekar
    South Med J 100:851-2. 2007
  27. ncbi Leg ulcers in New Zealand: age at onset, recurrence and provision of care in an urban population
    Natalie Walker
    Clinical Trials Research Unit, University of Auckland
    N Z Med J 115:286-9. 2002
    ..To describe the age at onset, recurrence rate, and provision of care for people with leg ulcers in New Zealand...
  28. ncbi Microbiological profile of chronic ulcers of the lower limb: a prospective observational cohort study
    Taos Lim
    Department of Vascular Surgery, Royal Perth Hospital, WA, Australia
    ANZ J Surg 76:688-92. 2006
    ..The aim of the study was to determine the microbiological profile of chronic lower-limb ulcers in a tertiary outpatient setting...
  29. ncbi The prevalence, management and outcome for patients with lower limb ulceration identified in a wound care survey within one English health care district
    Kathryn R Vowden
    Bradford Teaching Hospitals NHS Foundation Trust and University of Bradford, United Kingdom
    J Tissue Viability 18:13-9. 2009
    ..205 people had experienced previous episodes of leg ulcer occurrence. Of the leg ulcers encountered 18...
  30. ncbi Implementation of a leg ulcer strategy
    C J Moffatt
    Centre for Research and Implementation of Clinical Practice, Faculty of Health and Human Sciences, Thames Valley University, 32 38 Uxbridge Road, London W5 2BS, UK
    Br J Dermatol 151:857-67. 2004
    ..The care of patients with leg ulceration has developed over the past 15 years, although there is little information available to determine how these changes have affected clinical and patient defined outcomes...
  31. ncbi Therapy-resistant leg ulcer in a patient with Rothmund-Thomson syndrome
    Ilknur Altunay
    Department of Dermatology, Sisli Etfal Research and Training Hospital, Veysi Paşa sok Yucekent sit E 16, Altunizade Istanbul, Turkey
    Int Wound J 7:531-5. 2010
    ..We believe that this failure of healing might be to DNA repair abnormalities of fibroblasts. To our knowledge, this is the first case reported with coexistence of an unhealing ulcer without any findings of malignancy and RTS...
  32. ncbi Improving the treatment of leg ulcers
    G M McMullin
    Sutherland Hospital, Sydney, NSW
    Med J Aust 175:375-8. 2001
    ..However, it must be used for six hours a day, which precludes use by active patients. An ulcer that does not heal with three months of adequate compression therapy requires further investigation...
  33. ncbi Impact of tele-advice on community nurses' knowledge of venous leg ulcer care
    Jamal Ameen
    Division of Mathematics and Statistics, School of Technology, University of Glamorgan, Pontypridd, UK
    J Adv Nurs 50:583-94. 2005
    This paper reports a study assessing the impact of the provision of expert tele-advice to community nurses in enhancing their knowledge of leg ulcer care.
  34. pmc Knowledge and attitudes regarding care of leg ulcers. Survey of family physicians
    Ian D Graham
    Clinical Epidemiology Program, Ottawa Health Research Institute, Ottawa Hospital, Ont
    Can Fam Physician 49:896-902. 2003
    To determine family physicians' perceptions of and attitudes toward leg ulcer care and awareness of effective treatments for venous leg ulcers.
  35. pmc Complete healing of chronic wounds of a lower leg with haemoglobin spray and regeneration of an accompanying severe dermatoliposclerosis with intermittent normobaric oxygen inhalation (INBOI): a case report
    Wolfgang K R Barnikol
    Universitat Witten Herdecke, Bereich Klinische Physiologie, Witten, Germany
    Ger Med Sci 9:Doc08. 2011
    ..The new procedure may also be suitable even before the peri-ulceral oxygen partial pressure falls below 10 mmHg. Four measures for rehabilitation, conservation, and prevention with regard to a healed chronic wound are proposed...
  36. ncbi Adherence to leg ulcer lifestyle advice: qualitative and quantitative outcomes associated with a nurse-led intervention
    Ann Van Hecke
    Faculty of Medicine and Health Sciences, Department of Public Health Nursing Science, Ghent University, Ghent, Belgium
    J Clin Nurs 20:429-43. 2011
    Examining the (experienced) changes associated with a nursing intervention to enhance adherence to leg ulcer lifestyle advice.
  37. ncbi Healing of an MRSA-colonized, hydroxyurea-induced leg ulcer with honey
    S Natarajan
    Wound Healing Research Unit, University of Wales College of Medicine, Heath Park, Cardiff, UK
    J Dermatolog Treat 12:33-6. 2001
    ....
  38. ncbi Sociodemographic factors in chronic leg ulceration
    C J Moffatt
    Centre for Research and Implementation of Clinical Practice, Thames Valley University, 32 38 Uxbridge Road, London W5 2BS, UK
    Br J Dermatol 155:307-12. 2006
    ..While there is a commonly held belief that leg ulceration is associated with social factors, the evidence to support this is mainly anecdotal...
  39. ncbi The improvement of wound-associated pain and healing trajectory with a comprehensive foot and leg ulcer care model
    K Y Woo
    Clinical Scientist Wound Care Specialist, Wound Healing Clinic, Women s College Hospital, Toronto, Ontario, Canada
    J Wound Ostomy Continence Nurs 36:184-91; quiz 192-3. 2009
    ..The aim of this study was to validate an organized pain management approach using the Wound Associated Pain model in subjects with chronic leg and foot ulcers...
  40. ncbi Epidemiology, etiology, and treatment of chronic leg ulcer: experience with sixty patients
    G A Rahman
    Department of Surgery, University of Ilorin Teaching Hospital, Ilorin, Nigeria
    Ann Afr Med 9:1-4. 2010
    Chronic leg ulcer (CLU) is reported to have an impact on virtually all aspects of life. Treatment is expensive and has large economic burden on many countries' health services...
  41. ncbi Impact on wound healing and efficacy of various leg ulcer debridement techniques
    Martin Doerler
    Department of Dermatology, Venereology and Allergology, Vein Center, Departments of Dermatology and Vascular Surgery, University of Bochum, Hiltroper Landwehr 11 13, Bochum
    J Dtsch Dermatol Ges 10:624-32. 2012
    ..To evaluate the evidence on the impact of different debridement techniques on healing and their efficacy in the treatment of leg ulcers...
  42. ncbi A prospective evaluation of lower extremity ulcers in a Zimbabwean population
    Martin Sibanda
    Department of Surgery, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
    Int Wound J 6:361-6. 2009
    ..Immunosuppression because of HIV infection and NIDDM was noted in more than half of the patients. HIV infection may increase mortality in this group of patients...
  43. ncbi Meeting the psychosocial challenges of leg ulceration
    Christine Moffatt
    Centre for Research and Implementation of Clinical Practice, Thames Valley University, London
    Nurs Times 102:51-3. 2006
  44. ncbi Leg ulcer treatment
    Philip D Coleridge-Smith
    British Vein Institute, London, United Kingdom
    J Vasc Surg 49:804-8. 2009
    ..Perforating vein ligation is commonly combined with superficial venous surgery for leg ulcer patients, but no systematic data are available to define the role of this treatment...
  45. ncbi Martorell hypertensive ischemic leg ulcer: a model of ischemic subcutaneous arteriolosclerosis
    Jürg Hafner
    Department of Dermatology, University Hospital of Zurich, Switzerland
    Arch Dermatol 146:961-8. 2010
    To better define the diagnosis and treatment of Martorell hypertensive ischemic leg ulcer (HYTILU) and to compare Martorell HYTILU with calciphylaxis (calcific uremic arteriolopathy) and nonuremic forms of calciphylaxis.
  46. ncbi Supporting adherence and healthy lifestyles in leg ulcer patients: systematic development of the Lively Legs program for dermatology outpatient clinics
    Maud M Heinen
    Centre for Quality of Care Research, Radboud University Nijmegen Medical Centre, KWAZO 229, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Patient Educ Couns 61:279-91. 2006
    The objective of our project was to develop a lifestyle program for leg ulcer patients at outpatient clinics for dermatology.
  47. ncbi Leg ulcers: a review of their impact on daily life
    Anke Persoon
    Department of Nursing Science, University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Clin Nurs 13:341-54. 2004
    Current nursing care for leg ulcer patients often focuses on wound care and providing compression therapy. Nurses perceive leg ulcer patients as 'under-served' with regard to problems patients experience in daily life...
  48. pmc Combined therapy for pyoderma gangrenosum
    A P Rozin
    Ann Rheum Dis 63:888-9. 2004
  49. pmc Larval therapy for leg ulcers (VenUS II): randomised controlled trial
    Jo C Dumville
    Department of Health Sciences, University of York, York YO10 5DD, UK
    BMJ 338:b773. 2009
    ..To compare the clinical effectiveness of larval therapy with a standard debridement technique (hydrogel) for sloughy or necrotic leg ulcers...
  50. ncbi Leg ulcers in patients with sickle cell disease
    M Koshy
    Department of Medicine, University of Illinois, Chicago 60612
    Blood 74:1403-8. 1989
    ..0001) in sickle cell anemia patients. The protective effect of hemoglobin F is apparent at all levels of total hemoglobin among sickle cell anemia patients and those with associated alpha-thalassemia...
  51. pmc Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain
    James G Taylor
    Pulmonary and Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2095. 2008
    ..We have previously reported that intense hemolysis is associated with increased risk of vascular complications in a small cohort of adults with sickle cell disease. These observations have not been validated in other populations...
  52. ncbi Response of livedoid vasculitis to intravenous immunoglobulin
    F E Ravat
    Department of Dermatology, Ealing Hospital, Southall, Middlesex UB1 3HW, UK
    Br J Dermatol 147:166-9. 2002
    ..IVIg has been used successfully to treat a variety of vasculitic disorders and appears to be well tolerated. We suggest that this treatment is offered to patients who have livedoid vasculitis that is unresponsive to other therapies...
  53. ncbi Effect of electrical stimulation on chronic leg ulcer size and appearance
    Pamela E Houghton
    School of Physical Therapy, University of Western Ontario, Room 1443, London, Ontario, Canada N6G 1H1
    Phys Ther 83:17-28. 2003
    ..The purpose of this study was to examine the effect of high-voltage pulsed current (HVPC) on healing of chronic leg ulcers...
  54. ncbi Functional ability in female leg ulcer patients--a challenge for physiotherapy
    Kirsti Skavberg Roaldsen
    Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden
    Physiother Res Int 11:191-203. 2006
    ..The aim of the present study was to describe and quantify disease consequences in female leg ulcer patients as a background for future physiotherapy interventions, using the nomenclature of the WHO International ..
  55. ncbi Community leg ulcer bandaging study: lessons learned in a pilot, randomized controlled trial 
    Lisa Janette Smith
    Hotel Dieu Hospital, Kingston, Ontario, Canada
    Ostomy Wound Manage 56:32-42. 2010
    Compression is the cornerstone of venous leg ulcer (VLU) care but comparative effectiveness evidence is limited, especially regarding home care...
  56. ncbi Fear-avoidance beliefs and pain as predictors for low physical activity in patients with leg ulcer
    Kirsti Skavberg Roaldsen
    Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm, Sweden
    Physiother Res Int 14:167-80. 2009
    ....
  57. ncbi Painful ulcers in calciphylaxis - combined treatment with maggot therapy and oral pentoxyfillin
    J Tittelbach
    Department of Dermatology, Friedrich-Schiller University of Jena, Germany
    J Dermatolog Treat 12:211-4. 2001
    ..CONCLUSION: Patients suffering from ulcers due to calciphylaxis may benefit from the use of maggot therapy, which cleanses ulcers and prevents systemic infection...
  58. pmc Patient acceptability of larval therapy for leg ulcer treatment: a randomised survey to inform the sample size calculation of a randomised trial
    E S Petherick
    Centre for Evidence Based Nursing, Department of Health Sciences, University of York, Heslington, YO10 5DD, UK
    BMC Med Res Methodol 6:43. 2006
    ..Additionally there was concern that the use of larval therapy may require a larger effect size in time to healing than originally proposed by the investigators...
  59. pmc Nurse clinic versus home delivery of evidence-based community leg ulcer care: a randomized health services trial
    Margaret B Harrison
    School of Nursing, Queen s University, Kingston, Ontario, Canada
    BMC Health Serv Res 8:243. 2008
    International studies report that nurse clinics improve healing rates for the leg ulcer population. However, these studies did not necessarily deliver similar standards of care based on evidence in the treatment venues (home and clinic)...
  60. ncbi [Successful therapy of a rheumatoid leg ulcer with intravenous immunoglobulins]
    A Korber
    Klinik und Poliklinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Essen, Hufelandstrasse 55, 45122 Essen
    Hautarzt 57:1106-10. 2006
    ..Intravenous immunoglobulins represented an effective therapeutic option with fewer side effects in the therapy of vasculitis-induced leg ulceration in this patient with rheumatoid arthritis...
  61. ncbi Vacuum assisted closure device improves the take of mesh grafts in chronic leg ulcer patients
    A Korber
    Department of Dermatology, Essen University School of Medicine, Essen, Germany
    Dermatology 216:250-6. 2008
    ..Vacuum assisted closure (VAC) is established in the management of acute and chronic wounds. In recent years, few data have been published concerning VAC therapy after skin graft transplantation...
  62. pmc Leg-ulcer care in the community, before and after implementation of an evidence-based service
    Margaret B Harrison
    School of Nursing, Queen s University, Kingston, Ont
    CMAJ 172:1447-52. 2005
    ..Treatment is mainly provided in patients' homes; however, patients often receive poorly integrated services in multiple settings. We report the results of a prospective study of a community-based care strategy for leg ulcers...
  63. ncbi Surgical removal of ulcer and lipodermatosclerosis followed by split-skin grafting (shave therapy) yields good long-term results in "non-healing" venous leg ulcers
    W Schmeller
    Rosenparkklinik, Darmstadt, Germany
    Acta Derm Venereol 80:267-71. 2000
    ..Because it is only a symptomatic treatment which does not reduce the pathological refluxes, continuous compression of the lower leg is important...
  64. ncbi Older women's experience of living with chronic leg ulceration
    C Hyde
    Department of Clinical Nursing, Faculty of Nursing University of Sydney, Australia
    Int J Nurs Pract 5:189-98. 1999
    ..Recognition of the complex and sometimes hidden concerns of these women could help to avert the sense of helplessness which currently exists...
  65. ncbi Is wound healing a true science or a clinical art?
    Michael Clark
    Wound Healing Research Unit, Cardiff University, Cardiff Medicentre, Heath Park, Cardiff CF14 4UJ, UK
    Lancet 364:1388-9. 2004
  66. ncbi Standardised method of surgical treatment of chronic leg ulcers
    Mikael Bitsch
    Copenhagen Wound Healing Center, Bispebjerg Hospital, University Hospital, Denmark
    Scand J Plast Reconstr Surg Hand Surg 39:162-9. 2005
    ..Recurrence rate in venous and venous/ischaemic ulcers was 14% (33 in 235 legs) and 8% (n=3) in the traumatic ulcers. Vasculitic ulcers tend to recur 59% (n=10), but the graft does relieve pain...
  67. ncbi Leg ulcer in hereditary spherocytosis
    Susana Giraldi
    Division of Pediatric Dermatology, Department of Pediatrics, Federal University of Parana, Curitiba, Parana, Brazil
    Pediatr Dermatol 20:427-8. 2003
    ..All other etiologies were ruled out. Nine months after splenectomy the ulcer healed completely and the symptoms disappeared. We discuss and review this unusual entity in children...
  68. pmc Cost effectiveness analysis of larval therapy for leg ulcers
    Marta O Soares
    Department of Health Sciences, University of York, York YO10 5DD, UK
    BMJ 338:b825. 2009
    ..To assess the cost effectiveness of larval therapy compared with hydrogel in the management of leg ulcers...
  69. ncbi Are there clinical phenotypes of homozygous sickle cell disease?
    Neal Alexander
    Infectious Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London
    Br J Haematol 126:606-11. 2004
    ..A twofold model yielded groups that could be interpreted as painful crisis or leg ulcer phenotypes and 78% of patients were classified with 95% confidence into one of these...
  70. ncbi Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa
    Katarina Lundqvist
    Section for Dermatology, Department of Medical Microbiology, Dermatology and Infection, Lund University, Biomedical Center, Lund, Sweden
    Thromb Haemost 92:281-7. 2004
    ..Here, we show that chronic leg ulcer fluid, in contrast to wound fluid from acute wounds, contains highly increased levels of HBP...
  71. ncbi Leg ulcer presenting in a patient with congenital afibrinogenaemia
    Akira Kinebuchi
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Eur J Dermatol 12:70-2. 2002
    ..We report a case of congenital afibrinogenaemia presented with leg ulcer. A 30-year-old man presented with a history of prolonged bleeding from birth. His parents are cousins...
  72. ncbi Disrupted lives: investigating coping strategies for non-healing leg ulcers
    Alison Hopkins
    East London Wound Healing Centre, Tower Hamlets Primary Care Trust, London, UK
    Br J Nurs 13:556-63. 2004
    ..This study places leg ulceration within the body of literature on chronicity, linking nursing theory with the insights offered from health psychology...
  73. ncbi Evaluating the cost and efficacy of leg ulcer care provided in two large UK health authorities
    D A Ellison
    Academic Surgery Unit, Clinical Research Division II, South Manchester University Hospital, UK
    J Wound Care 11:47-51. 2002
    This prospective study investigated the cost and efficacy of leg ulcer care over a three-month period during 1993, 1994 and 1999. It compared two health authorities (Stockport and Trafford) whose populations totalled 540,000.
  74. ncbi Living with a chronic leg ulcer: an insight into patients' experiences and feelings
    V Douglas
    Rosemary Medical Centre, Poole
    J Wound Care 10:355-60. 2001
    ..This study sought to ascertain patient need and help health-care professionals to understand the effects of chronic leg ulceration from a patient's perspective...
  75. ncbi Allergic contact dermatitis to Plectranthus amboinicus masquerading as chronic leg ulcer
    Shyue Luen Chang
    Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Contact Dermatitis 53:356-7. 2005
    ..amboinicus by a patch test. The ulcer healed after discontinuation of P. amboinicus. To the best of our knowledge, this is the first reported case of allergic contact dermatitis to P. amboinicus masquerading as chronic leg ulcer.
  76. ncbi Static magnets prevent leg ulcer recurrence: savings for the NHS?
    Nyjon Eccles
    The Chiron Clinic, Harley Street Practice, London, UK
    Br J Community Nurs 11:S26, S28-30. 2006
    ..Extrapolating these results across the health economy, an estimate has been made of a potential pound153.7 million per year saving on leg ulcer care to the NHS.
  77. ncbi Matrix metalloproteinases and venous leg ulceration
    Y Herouy
    Department of Dermatology, University Hospital, Hauptstr 7, 79104 Freiburg, Germany
    Eur J Dermatol 10:173-80. 2000
    ..Different studies have revealed their significance in the process of proteolytic remodeling and recognized their potential importance in finding therapeutic rationales to manage late complications of chronic venous ulcers...
  78. ncbi Chronic leg ulcers, part 2: Do they affect a patient's social life?
    Annemarie Brown
    Castle Point and Rochford PCT and Southend PCT, Rayleigh Clinic, Essex
    Br J Nurs 14:986-9. 2005
    ..Part one discussed the background to the study, gave an overview of the literature and described the methodology. This second part will discuss the findings in relation to the literature together with implications for practice...
  79. ncbi Chronic leg ulcers, part 1: do they affect a patient's social life?
    Annemarie Brown
    Castle Point and Rochford PCT, Rayleigh Clinic, Essex, UK
    Br J Nurs 14:894-8. 2005
    ..The limitations of the study will be described, together with conclusions and recommendations for practice and further research...
  80. ncbi A pilot study to determine whether a static magnetic device can promote chronic leg ulcer healing
    N K Eccles
    The Chiron Clinic, London, UK
    J Wound Care 14:64-7. 2005
    ..To determine if UlcerCare, a specialised self-securing static magnetic device, can promote the healing of chronic leg ulcers...
  81. ncbi The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial
    A Abidia
    Academic Surgical Unit, University of Hull and Hull Royal Infirmary, Hull, U K
    Eur J Vasc Endovasc Surg 25:513-8. 2003
    ..The aim of this study was to evaluate the role of hyperbaric oxygen in the management of these ulcers...
  82. ncbi Adapting national and international leg ulcer practice guidelines for local use: the Ontario Leg Ulcer Community Care Protocol
    Ian D Graham
    School of Nursing, University of Ottawa, and Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Adv Skin Wound Care 18:307-18. 2005
    ..the authority responsible for home care in Ottawa, Ontario, Canada, established and evaluated a demonstration leg ulcer service...
  83. ncbi Improvement of idiopathic pyoderma gangrenosum during treatment with anti-tumor necrosis factor alfa monoclonal antibody
    Valentina Dini
    Wound Healing Research Unit, Department of Dermatology, University of Pisa, Pisa, Italy
    Int J Low Extrem Wounds 6:108-13. 2007
    ..The authors present a dramatic improvement in 4 cases of idiopathic PG of the lower leg treated with infliximab...
  84. pmc Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway
    Vikki G Nolan
    Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Br J Haematol 133:570-8. 2006
    ..b>Leg ulcer patients had lower haemoglobin levels and higher levels of lactate dehydrogenase, bilirubin, aspartate ..
  85. ncbi Asthma associated with worsening leg ulcer: a case of vasculitis in primary care
    Beril Cakir
    Internal Medicine Program, Moses Cone Hospital, 1200 N Elm Street, Greensboro, NC 27401, USA
    South Med J 96:677-80. 2003
    A 71-year-old black woman was admitted to the hospital with a 2-month history of a nonhealing leg ulcer. Her medical history included diabetes mellitus type 2, congestive heart failure, allergic rhinitis, and asthma...
  86. ncbi A new clinical trial of the effect of larval therapy
    Pauline Raynor
    Department of Health Sciences, University of York, Heslington
    J Tissue Viability 14:104-5. 2004
    ..This paper describes the aims and design of the trial, outlines the eligibility criteria for patients and discusses the nurses' role in the study. This article has not been subject to peer review...
  87. ncbi Skin grafting of a chronic leg ulcer with combined Versajet-V.A.C. therapy
    Christoph Stetter
    Department of Dermatology and Allergology, Center for Skin Diseases, Stuttgart Clinic, Germany
    J Dtsch Dermatol Ges 4:739-42. 2006
    ..After split-thickness skin grafting, V.A.C. therapy was continued. The result was excellent graft acceptance with complete wound healing. This case is unique in that a combination of both therapies resulted in complete wound healing...
  88. ncbi The effect of bacteria on leg ulcer healing
    J Harker
    Tissue Viability, Royal Oldham Hospital, Oldham
    Br J Community Nurs 6:126-34. 2001
    ..This article reviews a selection of the available literature regarding the effects of bacteria on leg ulcer healing. Attempts have been made to distinguish differing levels of bacterial presence (e.g...
  89. ncbi Barriers to conducting randomised controlled trials: lessons learnt from the Horsechestnut & Venous Leg Ulcer Trial (HAVLUT)
    Matthew J Leach
    University of South Australia, and Royal District Nursing Service, South Australia
    Contemp Nurse 15:37-47. 2003
    ..As illustrated through the recent Horsechestnut and Venous Leg Ulcer Trial (HAVLUT), these barriers can be attributed to randomisation, recruitment, retention, blinding and sampling ..
  90. pmc Maggot debridement therapy of infected ulcers: patient and wound factors influencing outcome - a study on 101 patients with 117 wounds
    Pascal Steenvoorde
    Department of Surgery, Rijnland Hospital Leiderdorp, Leiderdorp, The Netherlands
    Ann R Coll Surg Engl 89:596-602. 2007
    ..As it is still not clear which wounds are likely or unlikely to benefit from MDT, we performed a prospective study to gain more insight in patient and wound characteristics influencing outcome...
  91. ncbi Autologous full-thickness skin substitute for healing chronic wounds
    S Gibbs
    Department of Dermatology, VU Medical Centre, De Boelelaan, 1081 HV Amsterdam, The Netherlands
    Br J Dermatol 155:267-74. 2006
    ..Chronic wounds represent a major problem to our society. Therefore, advanced wound-healing strategies for the treatment of these wounds are expanding into the field of tissue engineering...
  92. ncbi New, improved Kerraboot: a tool for leg ulcer healing
    Dee Harvey
    Cheshire West
    Br J Community Nurs 11:S26, S28-30. 2006
    ..Although evidence of cost-effectiveness has yet to be collected, anecdotal reports suggest that the device heals wounds quickly and reduces input from health professionals...
  93. ncbi An introduction to various types of leg ulcers and their management
    Sylvie Hampton
    Eastbourne
    Br J Nurs 15:S9-13. 2006
    ..The pathway to appropriate treatment relies on a working knowledge of anatomy and physiology and good assessment. This article aims to provide a basic knowledge in how to recognize different leg ulcer types.
  94. ncbi Accurate diagnosis and effective treatment of leg ulcers reduce prevalence, care time and costs
    R F Oien
    Blekinge Wound Healing Centre, Lyckeby, Sweden
    J Wound Care 15:259-62. 2006
    ..This long-term follow-up recorded the prevalence, aetiology and treatment of hard-to-heal leg and foot ulcers, and an estimated nurses' time spent providing care, for the years 1994-2005...
  95. ncbi The debridement of hard to heal leg ulcers by means of a new device based on Fluidjet technology
    Giovanni Mosti
    Reparto di Angiologia e Cardiologia, Clinica Barbantini, Via Del Calcio 2, 55100 Lucca, Italy
    Int Wound J 2:307-14. 2005
    ..The results indicate that Versajet offers more precision than standard mechanical debridement and, at high settings, offers an alternative to surgical debridement...
  96. ncbi A retrospective review of 20 hypertensive leg ulcers treated with mesh skin grafts
    G Dagregorio
    Federation of Dermatology and Plastic Surgery, Centre Hospitalo Universitaire de Poitiers, rue de la Miletrie, Poitiers Cedex, France
    J Eur Acad Dermatol Venereol 20:166-9. 2006
    ..The present series consists of 15 patients whose hypertensive leg ulcers, including five bilateral cases, were treated with 20 mesh grafts from 2000 to 2002...
  97. ncbi Obesity: impediment to postsurgical wound healing
    Joyce A Wilson
    Department of General Surgery, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, TX, USA
    Adv Skin Wound Care 17:426-35. 2004
    ..3. Identify skin and wound care considerations for obese patients and the role of preplanning protocols in avoiding problems...
  98. ncbi Randomized trial of four-layer and two-layer bandage systems in the management of chronic venous ulceration
    Christine J Moffatt
    Centre for Research and Implementation of Clinical Practice, Thames Valley University, London, United Kingdom
    Wound Repair Regen 11:166-71. 2003
    ..In total, 112 patients newly presenting to leg ulcer services with chronic leg ulceration, screened to exclude the presence of arterial disease (ankle brachial ..
  99. ncbi Microcirculation is similar in ischemic and venous ulcers
    M E Gschwandtner
    Department of Medical Angiology, Vienna General Hospital, University of Vienna Medical School, , A-1090, Austria
    Microvasc Res 62:226-35. 2001
    ..Nutritive and subpapillary perfusion are involved in ulcer healing. In intact skin surrounding ischemic and venous ulcers, microcirculation is different due to the underlying pathophysiology...
  100. ncbi Healing an intractable wound using bio-electrical stimulation therapy
    Sylvie Hampton
    Dental Practice Board, Eastbourne, UK
    Br J Nurs 14:S30-2. 2005
    ..This situation relates to the woman in this case study who had a non-healing leg ulcer for 12 months...
  101. ncbi Subfascial endoscopic perforator vein surgery combined with saphenous vein ablation: results and critical analysis
    Christian Bianchi
    Division of Vascular Surgery, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    J Vasc Surg 38:67-71. 2003
    ..This study was undertaken to determine the results of subfascial endoscopic perforator vein surgery (SEPS) combined with ablation of superficial venous reflux...

Research Grants16

  1. PROTEASE MODULATING WOUND DRESSINGS FOR THE TREATMENT OF VENOUS ULCERS
    DAVID VACHON; Fiscal Year: 2006
    ..poor success rate burdens society with monthly healthcare costs estimated at approximately $2400 for each venous leg ulcer. It has been estimated that the annual treatment costs in the United States for hard to heal wounds is ..
  2. CHRONIC WOUNDS IN THE ELDERLY--A POPULATION APPROACH
    David Margolis; Fiscal Year: 2000
    ..medical profiles that can be used in clinically useful models to determine who is at risk for a venous leg ulcer or pressure ulcer...
  3. Venous Insufficiency Leg Ulcer Device
    PAUL BUREK; Fiscal Year: 2001
    ..Affecting approximately 5 million Americans and 1-3% of the elderly, the market for this device is substantial. If SOC proves efficacious, its' low cost and ease of use will allow for significant market penetration. ..
  4. Venous Insufficiency Leg Ulcer Device
    Jeffrey Jensen; Fiscal Year: 2006
    ..abstract_text> ..
  5. DISORDERED BLOOD COAGULATION IN SICKLE CELL DISEASE
    Kenneth Ataga; Fiscal Year: 2006
    ..The model on which they have chosen to test this hypothesis is the sickle cell leg ulcer, a chronic, painful, and often disabling complication for which there is to date, no effective therapy...
  6. Surrogate markers of complete venous ulcer healing
    Joel Gelfand; Fiscal Year: 2002
    Venous leg ulcer (VLU) is a common condition with substantial morbidity and a high cost in medical expenditures...
  7. PILOT TRIAL ON INNOVATIVE THERAPY FOR VENOUS LEG ULCER
    David Margolis; Fiscal Year: 1999
    This is a dual phase 1 set of studies on venous leg ulcer therapy, the goals of which are to (1) determine the maximum tolerated dose of an adenovirus vector based gene transfer of PDGF/B into chronic wounds, and (2) determine the ..
  8. Fibronectin peptides for treatment of burns
    Richard Clark; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. Endothelial Cell Regulation of Smooth Muscle Phenotype
    Richard Powell; Fiscal Year: 2007
    ..abstract_text> ..
  10. OXYGEN SENSING AND SIGNAL TRANSDUCTION
    H Bunn; Fiscal Year: 2003
    ..abstract_text> ..
  11. DERIVATIZED HYALURONAN FOR WOUND HEALING
    Richard Clark; Fiscal Year: 2001
    ..Finally it will be determined whether hyaluronan constructs that are optimal in vitro for cell migration are also optimal in vivo for cutaneous wound healing. ..
  12. SunSmart America: Evaluating a School-based Curriculum
    Robert Kirsner; Fiscal Year: 2008
    ..The results will be used for planning to implement the SunSmart America curriculum throughout Florida and nationwide. [unreadable] [unreadable] [unreadable]..
  13. REGULATION OF THE ERYTHROPOIETIN GENE
    H Bunn; Fiscal Year: 2003
    ..These studies should provide unique and highly relevant information about common mechanisms of oxygen sensing, signal transduction and gene regulation that enable organisms to adapt to hypoxia. ..
  14. Mechanisms By Which Endothelium Cells Sense Changes in Hemodynamics
    Bauer Sumpio; Fiscal Year: 2007
    ..4. Assess egr-1 and sp1 binding in MT1-MMP and PDGF-B promoters under mechanical stress 5.Assess the functional relevance of egr-1 in a low flow carotid model using an egr-1 knock-out mouse. ..