- Uncommon causes of ulceration
Girish K Patel
Cardiff University and Cardiff and Vale NHS Trust
BMJ 332:594-6. 2006
- Bactericidal activity of rifampin-amikacin against Mycobacterium ulcerans in mice
Faculté de Médecine Pitié Salpêtrière, Service de Bacteriologie et Hygiene, 75634 Paris Cedex 13, France
Antimicrob Agents Chemother 46:3193-6. 2002
..The promising results of RIF-AMK treatment in M. ulcerans-infected mice support the clinical trial that is currently in progress under World Health Organization auspices in Ghana...
- Early diagnosis is vital in the management of squamous cell carcinomas associated with chronic non healing ulcers: a case series and review of the literature
Clinical Research Fellow, Wound Healing Research Unit, University of Wales College of Medicine, Cardiff CF14 4NX, UK
Int Wound J 1:165-75. 2004
..Therefore, a low threshold to biopsy static non healing ulcers or ulcers in unusual sites should be adopted even in those not manifesting any evidence of malignancy...
- Ulceration as a predictive marker for response to adjuvant interferon therapy in melanoma
Kelly M McMasters
Department of Surgery, J Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
Ann Surg 252:460-5; discussion 465-6. 2010
..This analysis was performed to investigate the hypothesis that ulceration predicts improved response to adjuvant interferon (IFN) therapy...
- Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in northeastern Brazil
Departments of Medicine and Pediatrics, University of California, Los Angeles, USA
Am J Trop Med Hyg 80:574-9. 2009
..8% versus 75.0%; P < 0.001). Early treatment of ACL does not prevent lesion ulceration and is associated with higher rates of treatment failure...
- Atypical clinical variants in New World cutaneous leishmaniasis: disseminated, erysipeloid, and recidiva cutis due to Leishmania (V.) panamensis
Department of Parasitology, Kochi Medical School, Kochi University, Kochi, Japan
Am J Trop Med Hyg 73:281-4. 2005
..V.) panamensis was identified as the etiologic agent. Our cases extend the spectrum of clinical presentations in New World leishmaniasis...
- Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans
St George s Hospital Medical School, Department of Cellular and Molecular Medicine, Cranmer Terrace, London SW17 0RE, United Kingdom
Antimicrob Agents Chemother 49:3182-6. 2005
..ulcerans in human tissue, and it provides a basis for proceeding to a trial of antibiotic therapy as an alternative to surgery for early M. ulcerans disease...
- Current concepts in the management of Marjolin's ulcers: outcomes from a standardized treatment protocol in 16 cases
Department of Plastic, Reconstructive, and Aesthetic Surgery and Burn Center, Dicle University Medical Faculty, Diyarbakir, Turkey
J Burn Care Res 31:776-80. 2010
..5%) postoperatively. The authors conclude that diagnosis and surgical planning based on the recent literature must be carried out even more intensively to improve the prognosis of Marjolin's ulcer...
- Protective efficacy of a DNA vaccine encoding antigen 85A from Mycobacterium bovis BCG against Buruli ulcer
Mycobacterial Immunology, Pasteur Institute of Brussels, Brussels, Belgium
Infect Immun 69:5403-11. 2001
..Together, the results reported here support the potential of a cross-protective Ag85-based future vaccine against tuberculosis, Buruli ulcer, and leprosy...
- BCG vaccine effectiveness against Buruli ulcer: a case-control study in Benin
Unite d Epidemiologie, Ecole de Santé Publique, Universite Catholique de Louvain, Brussels, Belgium
Am J Trop Med Hyg 75:768-74. 2006
..2% in controls. There was no evidence of a protective effect of routine BCG vaccination against BU in southern Benin (vaccine effectiveness adjusted for socioeconomic status = 12%, 95% confidence interval = -24% to 37%)...
- Evidence for an intramacrophage growth phase of Mycobacterium ulcerans
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
Infect Immun 75:977-87. 2007
..The occurrence of an intramacrophage phase is in accordance with the development of cell-mediated and delayed-type hypersensitivity responses in BU patients...
- Methotrexate toxicity presenting as ulceration of psoriatic plaques: a report of two cases
Kishan Kumar Agarwal
Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research JIPMER, Pondicherry, India
Indian J Dermatol Venereol Leprol 74:481-4. 2008
..He also self medicated with oral methotrexate 15 mg daily for 7 days for exacerbation of psoriasis and developed ulceration of the psoriatic plaques with bone marrow suppression and evidence of gastrointestinal erosions...
- Differential production of systemic and intralesional gamma interferon and interleukin-10 in nodular and ulcerative forms of Buruli disease
Immunologie des Leishmanies, Institut Pasteur de la Guyane, Cayenne, French Guyana
Infect Immun 72:958-65. 2004
..ulcerans-specific IFN-gamma response in Buruli disease patients...
- Marjolin's ulcer: a preventable complication of burns?
Plastic, Reconstructive, and Aesthetic Surgery Department, Medical Faculty, Adnan Menderes University, Aydin, Turkey
Plast Reconstr Surg 124:156e-64e. 2009
..Discuss the clinical features of Marjolin's ulcer. 2. Identify the risk factors for the development of Marjolin's ulcer. 3. Develop a surgical management plan for the treatment of Marjolin's ulcer...
- Aquatic plants stimulate the growth of and biofilm formation by Mycobacterium ulcerans in axenic culture and harbor these bacteria in the environment
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 75015 Paris, France
Appl Environ Microbiol 70:1097-103. 2004
..These observations implicate aquatic plants as a reservoir of M. ulcerans and add a new potential link in the chain of transmission of M. ulcerans to humans...
- Deficiency of the decorin core protein in the variant form of Ehlers-Danlos syndrome with chronic skin ulcer
Department of Dermatology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
J Dermatol Sci 27:95-103. 2001
..This patient presented clinical features of Ehlers-Danlos syndrome with a chronic skin ulcer. Western blotting revealed that the deficiency of dermatan sulfate was due to the defect of decorin core protein...
- [Marjolin's ulcer in chronic osteomyelitis: seven cases and a review of the literature]
Service de Chirurgie Orthopedique et Traumatologique, Hopital Ambroise Pare, 9, avenue Charles de Gaulle, 92104 Boulogne Cedex
Rev Chir Orthop Reparatrice Appar Mot 93:63-71. 2007
..Unstable wounds and scar tissue related to chronic osteitis can degenerate after a long period of chronic inflammation. We report seven cases...
- Acute methotrexate toxicity seen as plaque psoriasis ulceration and necrosis: A diagnostic clue
Julie L Fridlington
Westlake Dermatology, Austin, Texas, USA
Dermatol Online J 17:2. 2011
..Ulceration and necrosis of cutaneous psoriasis plaques may serve as a herald for the impending development of life-threatening pancytopenia in patients with acute methotrexate toxicity...
- Is surgery an effective and adequate treatment in advanced Marjolin's ulcer?
Dr Lütf Kirdar Kartal Education and Research Hospital, Plastic and Reconstructive Surgery Department, Yaliyolu Emanet Sok Telatar Apt, 49 9 Bostanci Istanbul, Turkey
Burns 31:421-31. 2005
..An aggressive combined approach is essential for treatment in early stages with high success rate. But there is no consensus for the treatment of advanced disease and results are generally unsuccessful...
- New model of radiation-induced skin ulcer in rats
Department of Plastic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
J Plast Surg Hand Surg 45:258-62. 2011
..Delayed wound healing was found in the irradiated groups compared with the unirradiated group (p = 0.01). There were no differences in the time of ulceration, except in the Day 7 group (p = 0.03)...
- Role of 18F-FDG PET/CT in the diagnosis of clinically suspected Marjolin ulcer
Department of Radiology, Hallym University Hangang Sacred Heart Hospital, 94 200 Yeongdeungpo dong 2 ga, Yeongdeungpo gu, Seoul 150 719, Korea
AJR Am J Roentgenol 199:1375-9. 2012
..The purpose of our study is to retrospectively determine the diagnostic role of (18)F-FDG PET/CT at the primary lesion site in burned patients with chronic nonhealing ulcers who are suspected of having Marjolin ulcers...
- [Buruli ulcer: risk of bone involvement! Apropos of 33 cases observed in Benin]
Centre Sanitaire et Nutritionnel Gbemonten de Zagnanado, Benin
Med Trop (Mars) 60:262-6. 2000
..Based on bacteriological and histological findings, several postulations can be made about underlying pathophysiological mechanisms. The role of Buruli toxin is dealt with in the discussion...
- Psychosocial aspects of health seeking behaviours of patients with Buruli ulcer in southern Benin
Health and Patient Education Unit RESO, Universite Catholique de Louvain, Brussels, Belgium
Trop Med Int Health 8:750-9. 2003
..They are unclear about the origin of the disease (environmental factors or sorcery) and treatment is considered devastating, expensive and ineffective in some cases...
- Beliefs and attitudes toward Buruli ulcer in Ghana
Department of Internal Medicine, Groningen University Hospital, The Netherlands
Am J Trop Med Hyg 67:207-13. 2002
..Stigma scores were higher in unaffected respondents and in a less endemic location. Education on the disease, usually propagated for early case detection, might be useful in reducing stigma...
- Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study
Rheumatology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
Ann Rheum Dis 71:67-70. 2012
..In 2009, a quantitative score, the capillaroscopic skin ulcer risk index (CSURI), calculated according to the formula 'D×M/N(2'), was proposed, which was highly predictive ..
- Aquatic snails, passive hosts of Mycobacterium ulcerans
Unité de Génétique bactérienne, Institut Pasteur, 75724 Paris, France
Appl Environ Microbiol 70:6296-8. 2004
..Water bugs, such as Naucoris cimicoides, a potential vector of M. ulcerans, were shown to be infected specifically by this bacterium after feeding on snails experimentally exposed to M. ulcerans...
- A great Marjolin's ulcer of the scalp invading outer calvarial bone and its different treatment with support of Medpor
Ilteris M Emsen
Numune State Hospital, Department of Plastic Reconstructive and Aesthetic Surgery, Erzurum, Turkey
J Craniofac Surg 19:1026-9. 2008
- Thirty-one cases of Marjolin's ulcer
Plastic and Reconstructive Surgery Department, Medical Faculty, Adnan Menderes University, Aydin, Turkey
Clin Exp Dermatol 28:138-41. 2003
..Four of the malignant ulcers had spread to regional lymph nodes, but there were no distant metastases. This study emphasizes that Marjolin's ulcer should be considered as a significant postburn complication...
- Platelet gel in the treatment of cutaneous ulcers: the experience of the Immunohaematology and Transfusion Centre of Parma
U O Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, Parma, Italy
Blood Transfus 8:237-47. 2010
..Platelet gel is being ever more frequently used to promote healing of cutaneous ulcers. However, the factors that determine the often variable clinical outcome of this procedure are still incompletely understood...
- Statins: potentially useful in therapy of systemic sclerosis-related Raynaud's phenomenon and digital ulcers
Department of Rheumatology, University of Alexandria, Alexandria, Egypt
J Rheumatol 35:1801-8. 2008
..Statins display pleiotropic effects on endothelial function that may potentially retard vascular injury. We evaluated the potential efficacy of statin therapy in endothelial dysfunction and in management of RP and DU...
- Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist
J H Korn
Boston University School of Medicine, Boston, MA 02118, USA
Arthritis Rheum 50:3985-93. 2004
..We investigated whether treatment with the endothelin receptor antagonist, bosentan, decreased the development of new digital ulcers in patients with SSc...
- Mycobacterium bovis BCG vaccination as prophylaxis against Mycobacterium ulcerans osteomyelitis in Buruli ulcer disease
Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, B 2000 Antwerp, Belgium
Infect Immun 72:62-5. 2004
..Protection against severe forms of BU and childhood tuberculosis would likewise be improved by this intervention...
- Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients
P Garcia de la Pena-Lefebvre
Servicio de Reumatologia, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 100 Madrid 28034, Spain
Rheumatology (Oxford) 47:464-6. 2008
..We also wanted to analyse the effect of bosentan on other skin and general outcome measurements...
- New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer
Department of Dermatology Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka Suita City, Osaka 565 0871, Japan
Rheumatol Int 28:1127-35. 2008
..From these results, it can be expected that Lipo-PGE1 will act favorably on intractable collagen diseases...
- Marjolin ulcer of the scalp: intruder of a burn scar
Gaye Taylan Calikapan
Plastic, Reconstructive, and Aesthetic Surgery Clinic, Dr Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey
J Craniofac Surg 19:1020-5. 2008
..A single huge scalp flap is often sufficient for soft tissue defects, and cranioplasty with methyl methacrylate is an appropriate option for reconstruction...
- Diabetes, hand and/or foot ulcers: a cross-sectional hospital-based study in Port Harcourt, Nigeria
College of Health Sciences, University of Port Harcourt, Port Harcourt, Nigeria
Diabetes Res Clin Pract 75:148-52. 2007
..The study aimed to establish the prevalence of diabetes mellitus and the pattern of diabetic hand and foot ulcers in hospitalized adult patients in a teaching hospital in Port Harcourt, Nigeria...
- Severe refractory fingertip ulcerations in a patient with scleroderma: successful treatment with sildenafil
Christopher Lee Colglazier
Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina, USA
J Rheumatol 32:2440-2. 2005
..We describe a patient with limited cutaneous systemic sclerosis who presented with severe nonhealing finger ulcerations despite conventional management, who showed marked improvement with oral sildenafil...
- Analysis of an IS2404-based nested PCR for diagnosis of Buruli ulcer disease in regions of Ghana where the disease is endemic
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
J Clin Microbiol 41:794-7. 2003
..ulcerans DNA in all 21 culture-confirmed patients. For future studies, small tissue samples, e.g., punch biopsy samples, might be sufficient for case confirmation...
- Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control
Paul D R Johnson
Department of Infectious Diseases, Austin Health, Heidelberg, Australia
PLoS Med 2:e108. 2005
- The contribution of the Fas/FasL apoptotic pathway in ulcer formation during Leishmania major-induced cutaneous Leishmaniasis
Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, 171 77 Stockholm, Sweden
Am J Pathol 166:1099-108. 2005
..Our results indicate that FasL-expressing effector T cells and macrophages may act to induce apoptosis and ulcer formation in Fas-expressing keratinocytes during L. major infection...
- Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
PLoS Med 4:e64. 2007
..Thus we set out to investigate whether those individuals might display any immune signatures of exposure to M. ulcerans-free insect predator bites, and whether those could correlate with protection...
- Immune response to infection with Mycobacterium ulcerans
T M Gooding
Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
Infect Immun 69:1704-7. 2001
..These findings may explain some of the distinct clinical and pathological features of M. ulcerans-induced disease...
- Digital ulcers: overt vascular disease in systemic sclerosis
Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
Rheumatology (Oxford) 48:iii19-24. 2009
- Low versus high-dose iloprost therapy over 21 days in patients with secondary Raynaud's phenomenon and systemic sclerosis: a randomized, open, single-center study
Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
J Rheumatol 35:1830-7. 2008
..We compared the efficacy of different dosages of longterm iloprost treatment on Raynaud's phenomenon (RP), ulcer healing, skin thickening, and progression of internal organ sclerosis in patients with systemic sclerosis (SSc)...
- [Malignant neoplasm in burn scar: Marjolin's ulcer. Report of two cases and review of the literature]
Baltazar Alberto Soto-Dávalos
Servicio de Piel y Partes Blandes, Instituto Nacional de Cancerologia, Mexico, D F
Cir Cir 76:329-31. 2008
..This condition is found three times more frequently in men than in women and is thought to be more aggressive than conventional squamous cell carcinoma of the skin...
- Marjolin's ulcers in sub-Saharan Africa
Peter M Nthumba
Department of Surgery, AIC Kijabe Hospital, Kijabe, 00220, Kenya
World J Surg 34:2272-7. 2010
..Trauma, its sequelae, and other chronic non-healing wounds are known to predispose to malignant degeneration. Not much is known of the demographics of Marjolin's ulcers in sub-Saharan Africa...
- A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab
Department of Orthopedic Surgery, Anjo Kosei Hospital, 28 Higashihiroaze, Anjo cho, Anjo, Aichi 466 8602, Japan
Mod Rheumatol 19:199-203. 2009
We report a case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis (RA) who received tocilizumab. A 65-year-old woman with a 20-year history of RA participated in a tocilizumab clinical trial...
- Natural history of ischemic digital ulcers in systemic sclerosis: single-center retrospective longitudinal study
Department of Internal Medicine, National Reference Center for Scleroderma, Claude Huriez Hospital, University of Lille, Lille, France
J Rheumatol 34:2423-30. 2007
..To describe the natural history of ischemic digital ulcers (DU) in systemic sclerosis (SSc)...
- Nicorandil-induced ulceration of the penis
Department of Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
Clin Exp Dermatol 33:215-6. 2008
- Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer
Timothy P Stinear
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 75725 Paris Cedex 15, France
Genome Res 17:192-200. 2007
..ulcerans and M. marinum. This work offers significant insight into the biology and evolution of mycobacterial pathogens and is an important component of international efforts to counter Buruli ulcer...
- Treatment of recalcitrant ulcers with allogeneic platelet gel from pooled platelets in aged hypomobile patients
Center of Transfusion Medicine and Immunohematology, Department of Regenerative Medicine, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
Biologicals 39:73-80. 2011
..This study supports efficacy and feasibility of allogeneic PG to treat recalcitrant ulcers in very elderly hypomobile patients for whom autologous blood processing may be difficult...
- Detection of Mycobacterium ulcerans in environmental samples during an outbreak of ulcerative disease
B C Ross
Department of Microbiology and Infectious Disease, Royal Children s Hospital, Melbourne, Victoria, Australia
Appl Environ Microbiol 63:4135-8. 1997
..This is the first time that M. ulcerans has been demonstrated to be present in the environment and supports the postulated epidemiology of disease due to this organism...
- "Mycobacterium ulcerans subsp. shinshuense" isolated from a skin ulcer lesion: identification based on 16S rRNA gene sequencing
Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama shi, Tokyo, Japan
J Clin Microbiol 45:3840-3. 2007
..Definitive identification involved IS2404 detection, 16S rRNA gene sequencing, and analysis of the 16S rRNA gene 3'-terminal region and the virulence plasmid pMUM001...
- Serologic response to culture filtrate antigens of Mycobacterium ulcerans during Buruli ulcer disease
K M Dobos
Emory University School of Medicine, Atlanta, GA 30303, USA
Emerg Infect Dis 6:158-64. 2000
..8%) of 13 tuberculosis patients. There was no correlation between disease stage and the onset of this serum antibody response. Our findings suggest that serologic testing may be useful in the diagnosis and surveillance of BU...
- Wounds and malignancy
Jennifer T Trent
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL, USA
Adv Skin Wound Care 16:31-4. 2003
- Stimulated neovascularization, inflammation resolution and collagen maturation in healing rat cutaneous wounds by a heparan sulfate glycosaminoglycan mimetic, OTR4120
Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Wound Repair Regen 17:840-52. 2009
..We conclude that OTR4120 is a potential matrix therapeutic agent that ensures the quality of normal cutaneous wound repair and may restore impaired wound healing characterized by deficient angiogenesis and prolonged inflammation...
- FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major
Department of Microbiology, Karolinska Institutet, MTC, 171 77 Stockholm, Sweden
Am J Pathol 170:227-39. 2007
..We propose that activation of Fas and TRAIL apoptosis pathways, in the presence of inflammatory mediators at the site of infection, leads to tissue destruction and ulceration during CL...
- Capillaroscopic skin ulcer risk index: a new prognostic tool for digital skin ulcer development in systemic sclerosis patients
University of Modena and Reggio Emilia, Modena, Italy
Arthritis Rheum 61:688-94. 2009
..The aim of our study was to develop a capillaroscopic skin ulcer risk index (CSURI) that can predict the onset of new digital ulcers by using nailfold videocapillaroscopy (NVC) ..
- Contiguous spread of Mycobacterium ulcerans in Buruli ulcer lesions analysed by histopathology and real-time PCR quantification of mycobacterial DNA
Molecular Immunology, Swiss Tropical Institute, Basel, Switzerland
J Pathol 208:119-28. 2006
..These results demonstrate that IS2404 real-time PCR analysis is a better tool than the less sensitive and only semi-quantitative microscopic enumeration of AFB for studying the dynamics of M. ulcerans infection in situ...
- Post-surgical assessment of excised tissue from patients with Buruli ulcer disease: progression of infection in macroscopically healthy tissue
Bernhard Nocht Institute for Tropical Medicine BNITM, Hamburg, Germany
Trop Med Int Health 10:1199-206. 2005
..To assess the central to peripheral progression of Mycobacterium ulcerans infection and the mycobacterial infiltration of excision margins, excised tissue was examined for signs of infection...
- Role of the wet-to-dry phase of cleansing in preparing the chronic wound bed for dressing application
Academy for Certified Wound Management, Embrach Zurich, Switzerland
J Wound Care 14:349-52. 2005
..The wet-to-dry phase is a method of cleansing that acts as an alternative to rinsing prior to the application of a modern wound dressing. Debris, exudate and pathogens are removed from the wound, reducing itching and inflammation...
- Managing wound care outcomes
Joint St Francis Xavier University, Cape Breton University Nursing Program, 1250 Grand Lake Road, Sydney, Nova Scotia B1M 1A2, Canada
Ostomy Wound Manage 51:54-6, 58, 59 passim. 2005
..64 per client per month after Protocol implementation. The Nova Scotia Protocol enables home care professionals to provide quality wound care and has since been issued as policy for Home Care in Nova Scotia...
- Sensitivity of PCR targeting the IS2404 insertion sequence of Mycobacterium ulcerans in an Assay using punch biopsy specimens for diagnosis of Buruli ulcer
Komfo Anokye Teaching Hospital, KNUST, Kumasi, Ghana
J Clin Microbiol 43:3650-6. 2005
..Histology and culture remain important as quality control tests, particularly in studies of treatment efficacy...
- Clinical aspects of full-thickness wound healing
Albert E Rivera
Department of Dermatology, Mt Sinai School of Medicine, New York, NY, USA
Clin Dermatol 25:39-48. 2007
..A plethora of wound-healing adjuncts have been developed to aid wound healing in diseased states, and a working knowledge of their use is beneficial in managing all full-thickness wounds...
- Buruli ulcer
BMJ 330:1402-3. 2005
- Wound care issues in the patient with cancer
Mary A Gerlach
Division of Nursing, St Joseph s Mercy of Macomb Hospital, 15855 Nineteen Mile Road, Clinton Township, MI 48038, USA
Nurs Clin North Am 40:295-323. 2005
..As evidence related to wound healing, products, and technology continues to increase,nurses can be at the forefront of putting into practice the science of wound healing for the benefit of patients...
- High rates of apoptosis in human Mycobacterium ulcerans culture-positive buruli ulcer skin lesions
Douglas S Walsh
Dermatology Service, Eisenhower Army Medical Center, Fort Gordon, Georgia 30905, USA
Am J Trop Med Hyg 73:410-5. 2005
- [Mycobacterium ulcerans disease (Buruli ulcer): surgical treatment of 102 cases in the Democratic Republic of Congo]
Unité de Mycobactériologie de l Institut de Médecine Tropicale d Anvers, Belgique
Med Trop (Mars) 65:444-8. 2005
..These findings undersscore the importance of early detection and treatment with antimycobacterials...
- Impaired wound healing
Nathan B Menke
Department of Emergency Medicine, VCU Reanimation, Engineering and Shock Center, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0614, USA
Clin Dermatol 25:19-25. 2007
..In addition, some initial complexity theoretical models are proposed to define and explain the underlying pathophysiology...
- Evaluation of pH measurement as a method of wound assessment
V K Shukla
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University Varanasi, India
J Wound Care 16:291-4. 2007
..To assess variations in wound pH levels and explore the relationship between wound pH and the state of wound healing...
- Consensus recommendations for the diagnosis, treatment and control of Mycobacterium ulcerans infection (Bairnsdale or Buruli ulcer) in Victoria, Australia
Paul D R Johnson
Department of Infectious Diseases, Austin Health, Melbourne, Victoria, Australia
Med J Aust 186:64-8. 2007
..For small lesions this may be all that is required. However, there is a role for antibiotics for more extensive disease, and their use may allow more conservative surgery...
- Outcomes for Mycobacterium ulcerans infection with combined surgery and antibiotic therapy: findings from a south-eastern Australian case series
Daniel P O'Brien
Barwon Health, Geelong, Victoria, Australia
Med J Aust 186:58-61. 2007
..To describe the effect of antibiotics on outcomes of treatment for Buruli or Bairnsdale ulcer (BU) in patients on the Bellarine Peninsula in south-eastern Australia...
- Mycobacterium ulcerans infection (Buruli or Bairnsdale ulcer): challenges in developing management strategies
Med J Aust 186:55-6. 2007
- A stepwise approach to the laboratory diagnosis of Buruli ulcer disease
Department of Infectious Diseases and Tropical Medicine DITM, University of Munich, Munich, Germany
Trop Med Int Health 12:89-96. 2007
..We reviewed diagnostic results in order to explore options for a modified, more practicable, cost-effective and timely approach to the laboratory diagnosis of BUD...
- In vivo evaluation of Kumazasa extract and chitosan films containing the extract against deep skin ulcer model in rats
Department of Drug Delivery Research, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
Biol Pharm Bull 30:2406-11. 2007
..abbreviated to ND and FD films, respectively, were examined for efficacy and healing features using a deep skin ulcer model in rats...
- Experience with local negative pressure (vacuum method) in the treatment of complex wounds
Division of Plastic Surgery, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, CEP 01403 002 São Paulo, Brazil
Sao Paulo Med J 124:150-3. 2006
..Use of topical negative pressure over difficult-to-heal wounds has been studied. The objective of this study was to analyze the effects from negative pressure in the treatment of complex wounds...
- Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings
Margaret A Fonder
Department of Dermatology, Johns Hopkins University, Baltimore, Maryland, USA
J Am Acad Dermatol 58:185-206. 2008
..It is critical for all dermatologists to understand the elements of diagnosis and therapy. We emphasize major aspects of diagnosis and present a simple classification of wound dressings with guidelines for usage and relative cost data...
- First case of Mycobacterium ulcerans disease (Bairnsdale or Buruli ulcer) acquired in New South Wales
Caroline J Lavender
Mycobacterium Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia
Med J Aust 186:62-3. 2007
..To our knowledge, this is the first case of M. ulcerans infection acquired in NSW...
- Nerve damage in Mycobacterium ulcerans-infected mice: probable cause of painlessness in buruli ulcer
Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
Am J Pathol 168:805-11. 2006
..Our study suggests that the painlessness of the disease may be partly due to intraneural invasion of bacilli. Further studies of nerve invasion in clinical samples are urgently needed...
- The local immune response in ulcerative lesions of Buruli disease
A E Kiszewski
Experimental Pathology Section, Department of Pathology, Salvador Zubiran National Institute of Medical Sciences and Nutrition, Vasco de Quiroga 15, Tlalpan, Mexico City CP 14000, Mexico
Clin Exp Immunol 143:445-51. 2006
- Cytokine response to antigen stimulation of whole blood from patients with Mycobacterium ulcerans disease compared to that from patients with tuberculosis
Komfo Anokye Teaching Hospital, KNUST, Kumasi, Ghana, and Department of Infectious Diseases, St George s University of London, London SW17 ORE, United Kingdom
Clin Vaccine Immunol 13:253-7. 2006
..ulcerans appeared to be more specific than M. ulcerans sonicate. In the early stages of M. ulcerans disease there was a mixed Th1 and Th2 cytokine response, but the Th1 response emerged as the dominant type...
- Acute complex traumas of the lower limbs: a modern reconstructive approach with negative pressure therapy
The Department of Plastic and Reconstructive Surgery Burn Center, Traumatological Center, Turin, Italy
Wound Repair Regen 15:589-94. 2007
..VAC therapy may represent a valid alternative to immediate reconstruction in selected cases of acute complex traumas of the lower limb and allows for a stable functional result, using a minimally invasive approach...
- Prevention of amputation caused by rheumatic diseases following a novel therapy of exposing bone marrow, occlusive dressing and subsequent epidermal grafting
Department of Dermatology, Graduate School of Medicine Osaka University, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
Br J Dermatol 152:664-72. 2005
..Wounds with exposed bones caused by rheumatic diseases commonly result in amputation despite progress in our understanding of wound-healing mechanisms...
- Is aloe vera effective for healing chronic wounds?
Massachusetts General Hospital, 32 Fruit Street, Boston, MA 02114, USA
J Wound Ostomy Continence Nurs 30:68-71. 2003
- Honey and sugar as a dressing for wounds and ulcers
Trop Doct 32:55. 2002
- [Contribution of gene amplification in Mycobacterium ulcerans detection in exudates and cutaneous biopsies in Côte d'Ivoire]
Unité de microbiologie moléculaire, Institut Pasteur de Côte d Ivoire, Laboratoire de Bacteriologie virologie
Bull Soc Pathol Exot 97:95-6. 2004
..ulcerans insertions sequences suggest that this technique performed with exudates and biopsy can be used to confirm a routine specific diagnosis of M. ulcerans and early screening of Buruli ulcer in Côte d'Ivoire...
- The Buruli type ulcer
Hanns P Schierle
Plast Reconstr Surg 109:2608. 2002
- [Multifocal forms of Buruli ulcer: clinical aspects and management difficulties in 11 cases]
Service de Chirurgie Plastique, reconstructrice, esthétique et de chirurgie de la main, Institut Raoul Follereau, BP 229, Adzopé, Cote d Ivoire
Bull Soc Pathol Exot 95:287-91. 2002
..The purpose of this study is to be more specific about the clinical aspects and to show how difficult it is for those multifocal forms of Buruli ulcer to be operated on...
- Topical exposure to exogenous ultraviolet-irradiated urocanic acid enhances Mycobacterium ulcerans infection in a Crl:IAF(HA)-hrBR hairless guinea-pig model of Buruli ulcer disease
R B Cope
Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
Photodermatol Photoimmunol Photomed 20:14-20. 2004
..ulcerans infection in the Crl:IAF(HA)-hrBR hairless guinea-pig model of human Buruli ulcer disease...
- Effects of growth factors on doxorubicin-induced skin necrosis: documentation of histomorphological alterations and early treatment by GM-CSF and G-CSF
Department of Plastic and Reconstructive Surgery, Hacettepe University School of Medicine, Samanpazari 06100 Ankara, Turkey
Ann Plast Surg 49:646-53. 2002
..The authors conclude that both saline and tissue growth factors (GM-CSF and G-CSF) are useful for the early treatment of doxorubicin extravasation; however, GM-CSF and G-CSF are more beneficial...
- [Facial localizations of Buruli ulcers: two cases]
Service de Chirurgie Maxillo faciale, Plastique et Reconstructrice, Centre Hospitalier Intercommunal de Villeneuve Saint Georges, 40, allée de la source, 94195 Villeneuve Saint Georges
Rev Stomatol Chir Maxillofac 104:231-4. 2003
..Treatment involved resection of the ulcer followed by total skin graft. Ulcer healing was observed after two months hospitalization in one patient. The other patient died...
- Histopathologic features of Mycobacterium ulcerans infection
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 9:651-656. 2003
..001). Defining histologic criteria for a diagnosis of Buruli ulcer disease is of clinical and public health importance since it would allow earlier treatment, leading to less deforming sequelae...
- Slow release iodine preparation and wound healing: in vitro effects consistent with lack of in vivo toxicity in human chronic wounds
L H Zhou
Department of Biochemistry, Roger Williams Medical Center, 50 Maude Street, Providence, RI 02908, USA
Br J Dermatol 146:365-74. 2002
..However, there have been no studies directly assessing the potential lack of toxicity of cadexomer iodine on human cutaneous tissues...
- Efficacy of moist exposed burn ointment in the management of cutaneous wounds and ulcers: a multicenter pilot study
Bishara S Atiyeh
Ann Plast Surg 48:226-7. 2002
- Ultraviolet radiation enhances both the nodular and ulcerative forms of Mycobacterium ulcerans infection in a Crl:IAF(HA)-hrBR hairless guinea pig model of Buruli ulcer disease
R B Cope
Department of Veterinary Basic Sciences, College of Veterinary Medicine, Oregon State University, Corvalis, OR, 97331, USA
Photodermatol Photoimmunol Photomed 18:271-9. 2002
..The hypothesis tested was that UV pre-exposure enhances both the nodular and ulcerative forms of M. ulcerans infection in the Crl:IAF(HA)-hrBR hairless guinea pig...
- [Buruli ulcer in Angolese refugees in the Kimpese area, Lower Congo, D.R. Congo]
Departement de Chirurgie, Cliniques Universitaires de Kinshasa, BP123, Kinshasa XI, RD Congo
Sante 13:39-41. 2003
..All patients were infected two years before their insertion. The group most affected are children under 15 with a predominance of masculine patients. The legs were the most affected. The most frequent form is the ulcerative form...
- Healing of chronic cutaneous wounds by topical treatment with basic fibroblast growth factor
Wound Healing Unit, 304th Hospital, Beijing 100037, China
Chin Med J (Engl) 115:331-5. 2002
..To evaluate the safety and efficacy of topical application of recombinant bovine basic fibroblast growth factor (rbFGF) on the healing of chronic cutaneous wounds...
- Treatment of chronic wounds with bone marrow-derived cells
Evangelos V Badiavas
Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
Arch Dermatol 139:510-6. 2003
..These patients had not previously responded to standard and advanced therapies, including bioengineered skin application and grafting with autologous skin...
- The clinical relevance of microbiology in acute and chronic wounds
Department of Rehabilitation Medicine and Leonard Davis Institute of Health Economics, University of Pennsylvania School of Medicine, Philadelphia, USA
Adv Skin Wound Care 16:12-23; quiz 24-5. 2003
..2. Identify methods of debridement and wounds for which they are appropriate. 3. Identify systemic antibiotic treatment options for acute and chronic wound infections...
- The skin. 2. Skin and wound assessment
Mid Cheshire Hospital Trust, Leighton Hospital, Cheshire
Nurs Times 98:41-4. 2002