skin ulcer

Summary

Top Publications

  1. pmc Uncommon causes of ulceration
    Girish K Patel
    Cardiff University and Cardiff and Vale NHS Trust
    BMJ 332:594-6. 2006
  2. pmc Bactericidal activity of rifampin-amikacin against Mycobacterium ulcerans in mice
    Herve Dega
    Faculté de Médecine Pitié Salpêtrière, Service de Bacteriologie et Hygiene, 75634 Paris Cedex 13, France
    Antimicrob Agents Chemother 46:3193-6. 2002
  3. ncbi Early diagnosis is vital in the management of squamous cell carcinomas associated with chronic non healing ulcers: a case series and review of the literature
    Stuart Enoch
    Clinical Research Fellow, Wound Healing Research Unit, University of Wales College of Medicine, Cardiff CF14 4NX, UK
    Int Wound J 1:165-75. 2004
  4. ncbi Ulceration as a predictive marker for response to adjuvant interferon therapy in melanoma
    Kelly M McMasters
    Department of Surgery, J Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    Ann Surg 252:460-5; discussion 465-6. 2010
  5. pmc Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in northeastern Brazil
    Alon Unger
    Departments of Medicine and Pediatrics, University of California, Los Angeles, USA
    Am J Trop Med Hyg 80:574-9. 2009
  6. ncbi Atypical clinical variants in New World cutaneous leishmaniasis: disseminated, erysipeloid, and recidiva cutis due to Leishmania (V.) panamensis
    Manuel Calvopina
    Department of Parasitology, Kochi Medical School, Kochi University, Kochi, Japan
    Am J Trop Med Hyg 73:281-4. 2005
  7. pmc Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans
    S Etuaful
    St George s Hospital Medical School, Department of Cellular and Molecular Medicine, Cranmer Terrace, London SW17 0RE, United Kingdom
    Antimicrob Agents Chemother 49:3182-6. 2005
  8. ncbi Current concepts in the management of Marjolin's ulcers: outcomes from a standardized treatment protocol in 16 cases
    Mehmet Bozkurt
    Department of Plastic, Reconstructive, and Aesthetic Surgery and Burn Center, Dicle University Medical Faculty, Diyarbakir, Turkey
    J Burn Care Res 31:776-80. 2010
  9. pmc Protective efficacy of a DNA vaccine encoding antigen 85A from Mycobacterium bovis BCG against Buruli ulcer
    A Tanghe
    Mycobacterial Immunology, Pasteur Institute of Brussels, Brussels, Belgium
    Infect Immun 69:5403-11. 2001
  10. ncbi BCG vaccine effectiveness against Buruli ulcer: a case-control study in Benin
    Fabienne Nackers
    Unite d Epidemiologie, Ecole de Santé Publique, Universite Catholique de Louvain, Brussels, Belgium
    Am J Trop Med Hyg 75:768-74. 2006

Detail Information

Publications214 found, 100 shown here

  1. pmc Uncommon causes of ulceration
    Girish K Patel
    Cardiff University and Cardiff and Vale NHS Trust
    BMJ 332:594-6. 2006
  2. pmc Bactericidal activity of rifampin-amikacin against Mycobacterium ulcerans in mice
    Herve Dega
    Faculté de Médecine Pitié Salpêtrière, Service de Bacteriologie et Hygiene, 75634 Paris Cedex 13, France
    Antimicrob Agents Chemother 46:3193-6. 2002
    ..The promising results of RIF-AMK treatment in M. ulcerans-infected mice support the clinical trial that is currently in progress under World Health Organization auspices in Ghana...
  3. ncbi Early diagnosis is vital in the management of squamous cell carcinomas associated with chronic non healing ulcers: a case series and review of the literature
    Stuart Enoch
    Clinical Research Fellow, Wound Healing Research Unit, University of Wales College of Medicine, Cardiff CF14 4NX, UK
    Int Wound J 1:165-75. 2004
    ..Therefore, a low threshold to biopsy static non healing ulcers or ulcers in unusual sites should be adopted even in those not manifesting any evidence of malignancy...
  4. ncbi Ulceration as a predictive marker for response to adjuvant interferon therapy in melanoma
    Kelly M McMasters
    Department of Surgery, J Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA
    Ann Surg 252:460-5; discussion 465-6. 2010
    ..This analysis was performed to investigate the hypothesis that ulceration predicts improved response to adjuvant interferon (IFN) therapy...
  5. pmc Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in northeastern Brazil
    Alon Unger
    Departments of Medicine and Pediatrics, University of California, Los Angeles, USA
    Am J Trop Med Hyg 80:574-9. 2009
    ..8% versus 75.0%; P < 0.001). Early treatment of ACL does not prevent lesion ulceration and is associated with higher rates of treatment failure...
  6. ncbi Atypical clinical variants in New World cutaneous leishmaniasis: disseminated, erysipeloid, and recidiva cutis due to Leishmania (V.) panamensis
    Manuel Calvopina
    Department of Parasitology, Kochi Medical School, Kochi University, Kochi, Japan
    Am J Trop Med Hyg 73:281-4. 2005
    ..V.) panamensis was identified as the etiologic agent. Our cases extend the spectrum of clinical presentations in New World leishmaniasis...
  7. pmc Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans
    S Etuaful
    St George s Hospital Medical School, Department of Cellular and Molecular Medicine, Cranmer Terrace, London SW17 0RE, United Kingdom
    Antimicrob Agents Chemother 49:3182-6. 2005
    ..ulcerans in human tissue, and it provides a basis for proceeding to a trial of antibiotic therapy as an alternative to surgery for early M. ulcerans disease...
  8. ncbi Current concepts in the management of Marjolin's ulcers: outcomes from a standardized treatment protocol in 16 cases
    Mehmet Bozkurt
    Department of Plastic, Reconstructive, and Aesthetic Surgery and Burn Center, Dicle University Medical Faculty, Diyarbakir, Turkey
    J Burn Care Res 31:776-80. 2010
    ..5%) postoperatively. The authors conclude that diagnosis and surgical planning based on the recent literature must be carried out even more intensively to improve the prognosis of Marjolin's ulcer...
  9. pmc Protective efficacy of a DNA vaccine encoding antigen 85A from Mycobacterium bovis BCG against Buruli ulcer
    A Tanghe
    Mycobacterial Immunology, Pasteur Institute of Brussels, Brussels, Belgium
    Infect Immun 69:5403-11. 2001
    ..Together, the results reported here support the potential of a cross-protective Ag85-based future vaccine against tuberculosis, Buruli ulcer, and leprosy...
  10. ncbi BCG vaccine effectiveness against Buruli ulcer: a case-control study in Benin
    Fabienne Nackers
    Unite d Epidemiologie, Ecole de Santé Publique, Universite Catholique de Louvain, Brussels, Belgium
    Am J Trop Med Hyg 75:768-74. 2006
    ..2% in controls. There was no evidence of a protective effect of routine BCG vaccination against BU in southern Benin (vaccine effectiveness adjusted for socioeconomic status = 12%, 95% confidence interval = -24% to 37%)...
  11. pmc Evidence for an intramacrophage growth phase of Mycobacterium ulcerans
    Egidio Torrado
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
    Infect Immun 75:977-87. 2007
    ..The occurrence of an intramacrophage phase is in accordance with the development of cell-mediated and delayed-type hypersensitivity responses in BU patients...
  12. ncbi Methotrexate toxicity presenting as ulceration of psoriatic plaques: a report of two cases
    Kishan Kumar Agarwal
    Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research JIPMER, Pondicherry, India
    Indian J Dermatol Venereol Leprol 74:481-4. 2008
    ..He also self medicated with oral methotrexate 15 mg daily for 7 days for exacerbation of psoriasis and developed ulceration of the psoriatic plaques with bone marrow suppression and evidence of gastrointestinal erosions...
  13. pmc Differential production of systemic and intralesional gamma interferon and interleukin-10 in nodular and ulcerative forms of Buruli disease
    Ghislaine Prévot
    Immunologie des Leishmanies, Institut Pasteur de la Guyane, Cayenne, French Guyana
    Infect Immun 72:958-65. 2004
    ..ulcerans-specific IFN-gamma response in Buruli disease patients...
  14. ncbi Marjolin's ulcer: a preventable complication of burns?
    Eray Copcu
    Plastic, Reconstructive, and Aesthetic Surgery Department, Medical Faculty, Adnan Menderes University, Aydin, Turkey
    Plast Reconstr Surg 124:156e-64e. 2009
    ..Discuss the clinical features of Marjolin's ulcer. 2. Identify the risk factors for the development of Marjolin's ulcer. 3. Develop a surgical management plan for the treatment of Marjolin's ulcer...
  15. pmc Aquatic plants stimulate the growth of and biofilm formation by Mycobacterium ulcerans in axenic culture and harbor these bacteria in the environment
    Laurent Marsollier
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 75015 Paris, France
    Appl Environ Microbiol 70:1097-103. 2004
    ..These observations implicate aquatic plants as a reservoir of M. ulcerans and add a new potential link in the chain of transmission of M. ulcerans to humans...
  16. ncbi Deficiency of the decorin core protein in the variant form of Ehlers-Danlos syndrome with chronic skin ulcer
    J Wu
    Department of Dermatology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Dermatol Sci 27:95-103. 2001
    ..This patient presented clinical features of Ehlers-Danlos syndrome with a chronic skin ulcer. Western blotting revealed that the deficiency of dermatan sulfate was due to the defect of decorin core protein...
  17. ncbi [Marjolin's ulcer in chronic osteomyelitis: seven cases and a review of the literature]
    T Bauer
    Service de Chirurgie Orthopedique et Traumatologique, Hopital Ambroise Pare, 9, avenue Charles de Gaulle, 92104 Boulogne Cedex
    Rev Chir Orthop Reparatrice Appar Mot 93:63-71. 2007
    ..Unstable wounds and scar tissue related to chronic osteitis can degenerate after a long period of chronic inflammation. We report seven cases...
  18. ncbi Acute methotrexate toxicity seen as plaque psoriasis ulceration and necrosis: A diagnostic clue
    Julie L Fridlington
    Westlake Dermatology, Austin, Texas, USA
    Dermatol Online J 17:2. 2011
    ..Ulceration and necrosis of cutaneous psoriasis plaques may serve as a herald for the impending development of life-threatening pancytopenia in patients with acute methotrexate toxicity...
  19. ncbi Is surgery an effective and adequate treatment in advanced Marjolin's ulcer?
    Eser Aydogdu
    Dr Lütf Kirdar Kartal Education and Research Hospital, Plastic and Reconstructive Surgery Department, Yaliyolu Emanet Sok Telatar Apt, 49 9 Bostanci Istanbul, Turkey
    Burns 31:421-31. 2005
    ..An aggressive combined approach is essential for treatment in early stages with high success rate. But there is no consensus for the treatment of advanced disease and results are generally unsuccessful...
  20. ncbi New model of radiation-induced skin ulcer in rats
    Megumi Takikawa
    Department of Plastic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Plast Surg Hand Surg 45:258-62. 2011
    ..Delayed wound healing was found in the irradiated groups compared with the unirradiated group (p = 0.01). There were no differences in the time of ulceration, except in the Day 7 group (p = 0.03)...
  21. ncbi Role of 18F-FDG PET/CT in the diagnosis of clinically suspected Marjolin ulcer
    Younghwan Ko
    Department of Radiology, Hallym University Hangang Sacred Heart Hospital, 94 200 Yeongdeungpo dong 2 ga, Yeongdeungpo gu, Seoul 150 719, Korea
    AJR Am J Roentgenol 199:1375-9. 2012
    ..The purpose of our study is to retrospectively determine the diagnostic role of (18)F-FDG PET/CT at the primary lesion site in burned patients with chronic nonhealing ulcers who are suspected of having Marjolin ulcers...
  22. ncbi [Buruli ulcer: risk of bone involvement! Apropos of 33 cases observed in Benin]
    V Lagarrigue
    Centre Sanitaire et Nutritionnel Gbemonten de Zagnanado, Benin
    Med Trop (Mars) 60:262-6. 2000
    ..Based on bacteriological and histological findings, several postulations can be made about underlying pathophysiological mechanisms. The role of Buruli toxin is dealt with in the discussion...
  23. ncbi Psychosocial aspects of health seeking behaviours of patients with Buruli ulcer in southern Benin
    Isabelle Aujoulat
    Health and Patient Education Unit RESO, Universite Catholique de Louvain, Brussels, Belgium
    Trop Med Int Health 8:750-9. 2003
    ..They are unclear about the origin of the disease (environmental factors or sorcery) and treatment is considered devastating, expensive and ineffective in some cases...
  24. ncbi Beliefs and attitudes toward Buruli ulcer in Ghana
    Ymkje Stienstra
    Department of Internal Medicine, Groningen University Hospital, The Netherlands
    Am J Trop Med Hyg 67:207-13. 2002
    ..Stigma scores were higher in unaffected respondents and in a less endemic location. Education on the disease, usually propagated for early case detection, might be useful in reducing stigma...
  25. ncbi Predictive role of capillaroscopic skin ulcer risk index in systemic sclerosis: a multicentre validation study
    M Sebastiani
    Rheumatology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Ann Rheum Dis 71:67-70. 2012
    ..In 2009, a quantitative score, the capillaroscopic skin ulcer risk index (CSURI), calculated according to the formula 'D×M/N(2'), was proposed, which was highly predictive ..
  26. pmc Aquatic snails, passive hosts of Mycobacterium ulcerans
    Laurent Marsollier
    Unité de Génétique bactérienne, Institut Pasteur, 75724 Paris, France
    Appl Environ Microbiol 70:6296-8. 2004
    ..Water bugs, such as Naucoris cimicoides, a potential vector of M. ulcerans, were shown to be infected specifically by this bacterium after feeding on snails experimentally exposed to M. ulcerans...
  27. ncbi A great Marjolin's ulcer of the scalp invading outer calvarial bone and its different treatment with support of Medpor
    Ilteris M Emsen
    Numune State Hospital, Department of Plastic Reconstructive and Aesthetic Surgery, Erzurum, Turkey
    J Craniofac Surg 19:1026-9. 2008
    ....
  28. ncbi Thirty-one cases of Marjolin's ulcer
    E Copcu
    Plastic and Reconstructive Surgery Department, Medical Faculty, Adnan Menderes University, Aydin, Turkey
    Clin Exp Dermatol 28:138-41. 2003
    ..Four of the malignant ulcers had spread to regional lymph nodes, but there were no distant metastases. This study emphasizes that Marjolin's ulcer should be considered as a significant postburn complication...
  29. pmc Platelet gel in the treatment of cutaneous ulcers: the experience of the Immunohaematology and Transfusion Centre of Parma
    Gino Bernuzzi
    U O Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Via Gramsci 14, Parma, Italy
    Blood Transfus 8:237-47. 2010
    ..Platelet gel is being ever more frequently used to promote healing of cutaneous ulcers. However, the factors that determine the often variable clinical outcome of this procedure are still incompletely understood...
  30. ncbi Statins: potentially useful in therapy of systemic sclerosis-related Raynaud's phenomenon and digital ulcers
    Anna Abou-Raya
    Department of Rheumatology, University of Alexandria, Alexandria, Egypt
    J Rheumatol 35:1801-8. 2008
    ..Statins display pleiotropic effects on endothelial function that may potentially retard vascular injury. We evaluated the potential efficacy of statin therapy in endothelial dysfunction and in management of RP and DU...
  31. ncbi Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist
    J H Korn
    Boston University School of Medicine, Boston, MA 02118, USA
    Arthritis Rheum 50:3985-93. 2004
    ..We investigated whether treatment with the endothelin receptor antagonist, bosentan, decreased the development of new digital ulcers in patients with SSc...
  32. pmc Mycobacterium bovis BCG vaccination as prophylaxis against Mycobacterium ulcerans osteomyelitis in Buruli ulcer disease
    F Portaels
    Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine, B 2000 Antwerp, Belgium
    Infect Immun 72:62-5. 2004
    ..Protection against severe forms of BU and childhood tuberculosis would likewise be improved by this intervention...
  33. ncbi Long-term experience of bosentan for treating ulcers and healed ulcers in systemic sclerosis patients
    P Garcia de la Pena-Lefebvre
    Servicio de Reumatologia, Hospital Ramon y Cajal, Carretera de Colmenar Km 9, 100 Madrid 28034, Spain
    Rheumatology (Oxford) 47:464-6. 2008
    ..We also wanted to analyse the effect of bosentan on other skin and general outcome measurements...
  34. ncbi New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer
    Hiroyuki Murota
    Department of Dermatology Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka Suita City, Osaka 565 0871, Japan
    Rheumatol Int 28:1127-35. 2008
    ..From these results, it can be expected that Lipo-PGE1 will act favorably on intractable collagen diseases...
  35. ncbi Marjolin ulcer of the scalp: intruder of a burn scar
    Gaye Taylan Calikapan
    Plastic, Reconstructive, and Aesthetic Surgery Clinic, Dr Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey
    J Craniofac Surg 19:1020-5. 2008
    ..A single huge scalp flap is often sufficient for soft tissue defects, and cranioplasty with methyl methacrylate is an appropriate option for reconstruction...
  36. ncbi Diabetes, hand and/or foot ulcers: a cross-sectional hospital-based study in Port Harcourt, Nigeria
    Chioma Unachukwu
    College of Health Sciences, University of Port Harcourt, Port Harcourt, Nigeria
    Diabetes Res Clin Pract 75:148-52. 2007
    ..The study aimed to establish the prevalence of diabetes mellitus and the pattern of diabetic hand and foot ulcers in hospitalized adult patients in a teaching hospital in Port Harcourt, Nigeria...
  37. ncbi Severe refractory fingertip ulcerations in a patient with scleroderma: successful treatment with sildenafil
    Christopher Lee Colglazier
    Section on Rheumatology and Immunology, Department of Internal Medicine, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina, USA
    J Rheumatol 32:2440-2. 2005
    ..We describe a patient with limited cutaneous systemic sclerosis who presented with severe nonhealing finger ulcerations despite conventional management, who showed marked improvement with oral sildenafil...
  38. pmc Analysis of an IS2404-based nested PCR for diagnosis of Buruli ulcer disease in regions of Ghana where the disease is endemic
    Ymkje Stienstra
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    J Clin Microbiol 41:794-7. 2003
    ..ulcerans DNA in all 21 culture-confirmed patients. For future studies, small tissue samples, e.g., punch biopsy samples, might be sufficient for case confirmation...
  39. pmc Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control
    Paul D R Johnson
    Department of Infectious Diseases, Austin Health, Heidelberg, Australia
    PLoS Med 2:e108. 2005
  40. pmc The contribution of the Fas/FasL apoptotic pathway in ulcer formation during Leishmania major-induced cutaneous Leishmaniasis
    Liv Eidsmo
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, 171 77 Stockholm, Sweden
    Am J Pathol 166:1099-108. 2005
    ..Our results indicate that FasL-expressing effector T cells and macrophages may act to induce apoptosis and ulcer formation in Fas-expressing keratinocytes during L. major infection...
  41. pmc Protection against Mycobacterium ulcerans lesion development by exposure to aquatic insect saliva
    Laurent Marsollier
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    PLoS Med 4:e64. 2007
    ..Thus we set out to investigate whether those individuals might display any immune signatures of exposure to M. ulcerans-free insect predator bites, and whether those could correlate with protection...
  42. pmc Immune response to infection with Mycobacterium ulcerans
    T M Gooding
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    Infect Immun 69:1704-7. 2001
    ..These findings may explain some of the distinct clinical and pathological features of M. ulcerans-induced disease...
  43. ncbi Digital ulcers: overt vascular disease in systemic sclerosis
    V Steen
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20007, USA
    Rheumatology (Oxford) 48:iii19-24. 2009
    ....
  44. ncbi Low versus high-dose iloprost therapy over 21 days in patients with secondary Raynaud's phenomenon and systemic sclerosis: a randomized, open, single-center study
    Annegret Kawald
    Department of Rheumatology and Clinical Immunology, Charite University Hospital, Berlin, Germany
    J Rheumatol 35:1830-7. 2008
    ..We compared the efficacy of different dosages of longterm iloprost treatment on Raynaud's phenomenon (RP), ulcer healing, skin thickening, and progression of internal organ sclerosis in patients with systemic sclerosis (SSc)...
  45. ncbi [Malignant neoplasm in burn scar: Marjolin's ulcer. Report of two cases and review of the literature]
    Baltazar Alberto Soto-Dávalos
    Servicio de Piel y Partes Blandes, Instituto Nacional de Cancerologia, Mexico, D F
    Cir Cir 76:329-31. 2008
    ..This condition is found three times more frequently in men than in women and is thought to be more aggressive than conventional squamous cell carcinoma of the skin...
  46. ncbi Marjolin's ulcers in sub-Saharan Africa
    Peter M Nthumba
    Department of Surgery, AIC Kijabe Hospital, Kijabe, 00220, Kenya
    World J Surg 34:2272-7. 2010
    ..Trauma, its sequelae, and other chronic non-healing wounds are known to predispose to malignant degeneration. Not much is known of the demographics of Marjolin's ulcers in sub-Saharan Africa...
  47. ncbi A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab
    Fumiaki Sugiura
    Department of Orthopedic Surgery, Anjo Kosei Hospital, 28 Higashihiroaze, Anjo cho, Anjo, Aichi 466 8602, Japan
    Mod Rheumatol 19:199-203. 2009
    We report a case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis (RA) who received tocilizumab. A 65-year-old woman with a 20-year history of RA participated in a tocilizumab clinical trial...
  48. ncbi Natural history of ischemic digital ulcers in systemic sclerosis: single-center retrospective longitudinal study
    Eric Hachulla
    Department of Internal Medicine, National Reference Center for Scleroderma, Claude Huriez Hospital, University of Lille, Lille, France
    J Rheumatol 34:2423-30. 2007
    ..To describe the natural history of ischemic digital ulcers (DU) in systemic sclerosis (SSc)...
  49. doi Nicorandil-induced ulceration of the penis
    A Birnie
    Department of Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Clin Exp Dermatol 33:215-6. 2008
  50. pmc Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer
    Timothy P Stinear
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 75725 Paris Cedex 15, France
    Genome Res 17:192-200. 2007
    ..ulcerans and M. marinum. This work offers significant insight into the biology and evolution of mycobacterial pathogens and is an important component of international efforts to counter Buruli ulcer...
  51. ncbi Treatment of recalcitrant ulcers with allogeneic platelet gel from pooled platelets in aged hypomobile patients
    N Greppi
    Center of Transfusion Medicine and Immunohematology, Department of Regenerative Medicine, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Biologicals 39:73-80. 2011
    ..This study supports efficacy and feasibility of allogeneic PG to treat recalcitrant ulcers in very elderly hypomobile patients for whom autologous blood processing may be difficult...
  52. pmc Detection of Mycobacterium ulcerans in environmental samples during an outbreak of ulcerative disease
    B C Ross
    Department of Microbiology and Infectious Disease, Royal Children s Hospital, Melbourne, Victoria, Australia
    Appl Environ Microbiol 63:4135-8. 1997
    ..This is the first time that M. ulcerans has been demonstrated to be present in the environment and supports the postulated epidemiology of disease due to this organism...
  53. pmc "Mycobacterium ulcerans subsp. shinshuense" isolated from a skin ulcer lesion: identification based on 16S rRNA gene sequencing
    Kazue Nakanaga
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama shi, Tokyo, Japan
    J Clin Microbiol 45:3840-3. 2007
    ..Definitive identification involved IS2404 detection, 16S rRNA gene sequencing, and analysis of the 16S rRNA gene 3'-terminal region and the virulence plasmid pMUM001...
  54. pmc Serologic response to culture filtrate antigens of Mycobacterium ulcerans during Buruli ulcer disease
    K M Dobos
    Emory University School of Medicine, Atlanta, GA 30303, USA
    Emerg Infect Dis 6:158-64. 2000
    ..8%) of 13 tuberculosis patients. There was no correlation between disease stage and the onset of this serum antibody response. Our findings suggest that serologic testing may be useful in the diagnosis and surveillance of BU...
  55. ncbi Wounds and malignancy
    Jennifer T Trent
    Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, FL, USA
    Adv Skin Wound Care 16:31-4. 2003
    ....
  56. ncbi Stimulated neovascularization, inflammation resolution and collagen maturation in healing rat cutaneous wounds by a heparan sulfate glycosaminoglycan mimetic, OTR4120
    Miao Tong
    Department of Plastic and Reconstructive Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Wound Repair Regen 17:840-52. 2009
    ..We conclude that OTR4120 is a potential matrix therapeutic agent that ensures the quality of normal cutaneous wound repair and may restore impaired wound healing characterized by deficient angiogenesis and prolonged inflammation...
  57. pmc FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major
    Liv Eidsmo
    Department of Microbiology, Karolinska Institutet, MTC, 171 77 Stockholm, Sweden
    Am J Pathol 170:227-39. 2007
    ..We propose that activation of Fas and TRAIL apoptosis pathways, in the presence of inflammatory mediators at the site of infection, leads to tissue destruction and ulceration during CL...
  58. ncbi Capillaroscopic skin ulcer risk index: a new prognostic tool for digital skin ulcer development in systemic sclerosis patients
    M Sebastiani
    University of Modena and Reggio Emilia, Modena, Italy
    Arthritis Rheum 61:688-94. 2009
    ..The aim of our study was to develop a capillaroscopic skin ulcer risk index (CSURI) that can predict the onset of new digital ulcers by using nailfold videocapillaroscopy (NVC) ..
  59. ncbi Contiguous spread of Mycobacterium ulcerans in Buruli ulcer lesions analysed by histopathology and real-time PCR quantification of mycobacterial DNA
    Simona Rondini
    Molecular Immunology, Swiss Tropical Institute, Basel, Switzerland
    J Pathol 208:119-28. 2006
    ..These results demonstrate that IS2404 real-time PCR analysis is a better tool than the less sensitive and only semi-quantitative microscopic enumeration of AFB for studying the dynamics of M. ulcerans infection in situ...
  60. ncbi Post-surgical assessment of excised tissue from patients with Buruli ulcer disease: progression of infection in macroscopically healthy tissue
    G Bretzel
    Bernhard Nocht Institute for Tropical Medicine BNITM, Hamburg, Germany
    Trop Med Int Health 10:1199-206. 2005
    ..To assess the central to peripheral progression of Mycobacterium ulcerans infection and the mycobacterial infiltration of excision margins, excised tissue was examined for signs of infection...
  61. ncbi Role of the wet-to-dry phase of cleansing in preparing the chronic wound bed for dressing application
    G Kammerlander
    Academy for Certified Wound Management, Embrach Zurich, Switzerland
    J Wound Care 14:349-52. 2005
    ..The wet-to-dry phase is a method of cleansing that acts as an alternative to rinsing prior to the application of a modern wound dressing. Debris, exudate and pathogens are removed from the wound, reducing itching and inflammation...
  62. ncbi Managing wound care outcomes
    Corrine McIsaac
    Joint St Francis Xavier University, Cape Breton University Nursing Program, 1250 Grand Lake Road, Sydney, Nova Scotia B1M 1A2, Canada
    Ostomy Wound Manage 51:54-6, 58, 59 passim. 2005
    ..64 per client per month after Protocol implementation. The Nova Scotia Protocol enables home care professionals to provide quality wound care and has since been issued as policy for Home Care in Nova Scotia...
  63. pmc Sensitivity of PCR targeting the IS2404 insertion sequence of Mycobacterium ulcerans in an Assay using punch biopsy specimens for diagnosis of Buruli ulcer
    R Phillips
    Komfo Anokye Teaching Hospital, KNUST, Kumasi, Ghana
    J Clin Microbiol 43:3650-6. 2005
    ..Histology and culture remain important as quality control tests, particularly in studies of treatment efficacy...
  64. ncbi Clinical aspects of full-thickness wound healing
    Albert E Rivera
    Department of Dermatology, Mt Sinai School of Medicine, New York, NY, USA
    Clin Dermatol 25:39-48. 2007
    ..A plethora of wound-healing adjuncts have been developed to aid wound healing in diseased states, and a working knowledge of their use is beneficial in managing all full-thickness wounds...
  65. pmc Buruli ulcer
    Mark Wansbrough-Jones
    BMJ 330:1402-3. 2005
  66. ncbi Wound care issues in the patient with cancer
    Mary A Gerlach
    Division of Nursing, St Joseph s Mercy of Macomb Hospital, 15855 Nineteen Mile Road, Clinton Township, MI 48038, USA
    Nurs Clin North Am 40:295-323. 2005
    ..As evidence related to wound healing, products, and technology continues to increase,nurses can be at the forefront of putting into practice the science of wound healing for the benefit of patients...
  67. ncbi High rates of apoptosis in human Mycobacterium ulcerans culture-positive buruli ulcer skin lesions
    Douglas S Walsh
    Dermatology Service, Eisenhower Army Medical Center, Fort Gordon, Georgia 30905, USA
    Am J Trop Med Hyg 73:410-5. 2005
    ..ulcerans...
  68. ncbi [Mycobacterium ulcerans disease (Buruli ulcer): surgical treatment of 102 cases in the Democratic Republic of Congo]
    K Kibadi
    Unité de Mycobactériologie de l Institut de Médecine Tropicale d Anvers, Belgique
    Med Trop (Mars) 65:444-8. 2005
    ..These findings undersscore the importance of early detection and treatment with antimycobacterials...
  69. ncbi Impaired wound healing
    Nathan B Menke
    Department of Emergency Medicine, VCU Reanimation, Engineering and Shock Center, Virginia Commonwealth University Medical Center, Richmond, VA 23298 0614, USA
    Clin Dermatol 25:19-25. 2007
    ..In addition, some initial complexity theoretical models are proposed to define and explain the underlying pathophysiology...
  70. ncbi Evaluation of pH measurement as a method of wound assessment
    V K Shukla
    Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University Varanasi, India
    J Wound Care 16:291-4. 2007
    ..To assess variations in wound pH levels and explore the relationship between wound pH and the state of wound healing...
  71. ncbi Consensus recommendations for the diagnosis, treatment and control of Mycobacterium ulcerans infection (Bairnsdale or Buruli ulcer) in Victoria, Australia
    Paul D R Johnson
    Department of Infectious Diseases, Austin Health, Melbourne, Victoria, Australia
    Med J Aust 186:64-8. 2007
    ..For small lesions this may be all that is required. However, there is a role for antibiotics for more extensive disease, and their use may allow more conservative surgery...
  72. ncbi Outcomes for Mycobacterium ulcerans infection with combined surgery and antibiotic therapy: findings from a south-eastern Australian case series
    Daniel P O'Brien
    Barwon Health, Geelong, Victoria, Australia
    Med J Aust 186:58-61. 2007
    ..To describe the effect of antibiotics on outcomes of treatment for Buruli or Bairnsdale ulcer (BU) in patients on the Bellarine Peninsula in south-eastern Australia...
  73. ncbi Mycobacterium ulcerans infection (Buruli or Bairnsdale ulcer): challenges in developing management strategies
    Kingsley Asiedu
    Med J Aust 186:55-6. 2007
  74. ncbi A stepwise approach to the laboratory diagnosis of Buruli ulcer disease
    G Bretzel
    Department of Infectious Diseases and Tropical Medicine DITM, University of Munich, Munich, Germany
    Trop Med Int Health 12:89-96. 2007
    ..We reviewed diagnostic results in order to explore options for a modified, more practicable, cost-effective and timely approach to the laboratory diagnosis of BUD...
  75. ncbi In vivo evaluation of Kumazasa extract and chitosan films containing the extract against deep skin ulcer model in rats
    Kaori Hirose
    Department of Drug Delivery Research, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Biol Pharm Bull 30:2406-11. 2007
    ..abbreviated to ND and FD films, respectively, were examined for efficacy and healing features using a deep skin ulcer model in rats...
  76. ncbi Experience with local negative pressure (vacuum method) in the treatment of complex wounds
    Alexandre Wada
    Division of Plastic Surgery, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, CEP 01403 002 São Paulo, Brazil
    Sao Paulo Med J 124:150-3. 2006
    ..Use of topical negative pressure over difficult-to-heal wounds has been studied. The objective of this study was to analyze the effects from negative pressure in the treatment of complex wounds...
  77. ncbi Treating the chronic wound: A practical approach to the care of nonhealing wounds and wound care dressings
    Margaret A Fonder
    Department of Dermatology, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Acad Dermatol 58:185-206. 2008
    ..It is critical for all dermatologists to understand the elements of diagnosis and therapy. We emphasize major aspects of diagnosis and present a simple classification of wound dressings with guidelines for usage and relative cost data...
  78. ncbi First case of Mycobacterium ulcerans disease (Bairnsdale or Buruli ulcer) acquired in New South Wales
    Caroline J Lavender
    Mycobacterium Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia
    Med J Aust 186:62-3. 2007
    ..To our knowledge, this is the first case of M. ulcerans infection acquired in NSW...
  79. pmc Nerve damage in Mycobacterium ulcerans-infected mice: probable cause of painlessness in buruli ulcer
    Masamichi Goto
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Am J Pathol 168:805-11. 2006
    ..Our study suggests that the painlessness of the disease may be partly due to intraneural invasion of bacilli. Further studies of nerve invasion in clinical samples are urgently needed...
  80. pmc The local immune response in ulcerative lesions of Buruli disease
    A E Kiszewski
    Experimental Pathology Section, Department of Pathology, Salvador Zubiran National Institute of Medical Sciences and Nutrition, Vasco de Quiroga 15, Tlalpan, Mexico City CP 14000, Mexico
    Clin Exp Immunol 143:445-51. 2006
    ....
  81. pmc Cytokine response to antigen stimulation of whole blood from patients with Mycobacterium ulcerans disease compared to that from patients with tuberculosis
    R Phillips
    Komfo Anokye Teaching Hospital, KNUST, Kumasi, Ghana, and Department of Infectious Diseases, St George s University of London, London SW17 ORE, United Kingdom
    Clin Vaccine Immunol 13:253-7. 2006
    ..ulcerans appeared to be more specific than M. ulcerans sonicate. In the early stages of M. ulcerans disease there was a mixed Th1 and Th2 cytokine response, but the Th1 response emerged as the dominant type...
  82. ncbi Acute complex traumas of the lower limbs: a modern reconstructive approach with negative pressure therapy
    Daniele Bollero
    The Department of Plastic and Reconstructive Surgery Burn Center, Traumatological Center, Turin, Italy
    Wound Repair Regen 15:589-94. 2007
    ..VAC therapy may represent a valid alternative to immediate reconstruction in selected cases of acute complex traumas of the lower limb and allows for a stable functional result, using a minimally invasive approach...
  83. ncbi Prevention of amputation caused by rheumatic diseases following a novel therapy of exposing bone marrow, occlusive dressing and subsequent epidermal grafting
    Y Yamaguchi
    Department of Dermatology, Graduate School of Medicine Osaka University, 2 2 Yamada oka, Suita Shi, Osaka 565 0871, Japan
    Br J Dermatol 152:664-72. 2005
    ..Wounds with exposed bones caused by rheumatic diseases commonly result in amputation despite progress in our understanding of wound-healing mechanisms...
  84. ncbi Is aloe vera effective for healing chronic wounds?
    Joan Gallagher
    Massachusetts General Hospital, 32 Fruit Street, Boston, MA 02114, USA
    J Wound Ostomy Continence Nurs 30:68-71. 2003
  85. ncbi Honey and sugar as a dressing for wounds and ulcers
    Winit Phuapradit
    Trop Doct 32:55. 2002
  86. ncbi [Contribution of gene amplification in Mycobacterium ulcerans detection in exudates and cutaneous biopsies in Côte d'Ivoire]
    E Ekaza
    Unité de microbiologie moléculaire, Institut Pasteur de Côte d Ivoire, Laboratoire de Bacteriologie virologie
    Bull Soc Pathol Exot 97:95-6. 2004
    ..ulcerans insertions sequences suggest that this technique performed with exudates and biopsy can be used to confirm a routine specific diagnosis of M. ulcerans and early screening of Buruli ulcer in Côte d'Ivoire...
  87. ncbi The Buruli type ulcer
    Hanns P Schierle
    Plast Reconstr Surg 109:2608. 2002
  88. ncbi [Multifocal forms of Buruli ulcer: clinical aspects and management difficulties in 11 cases]
    D Ouattara
    Service de Chirurgie Plastique, reconstructrice, esthétique et de chirurgie de la main, Institut Raoul Follereau, BP 229, Adzopé, Cote d Ivoire
    Bull Soc Pathol Exot 95:287-91. 2002
    ..The purpose of this study is to be more specific about the clinical aspects and to show how difficult it is for those multifocal forms of Buruli ulcer to be operated on...
  89. ncbi Topical exposure to exogenous ultraviolet-irradiated urocanic acid enhances Mycobacterium ulcerans infection in a Crl:IAF(HA)-hrBR hairless guinea-pig model of Buruli ulcer disease
    R B Cope
    Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
    Photodermatol Photoimmunol Photomed 20:14-20. 2004
    ..ulcerans infection in the Crl:IAF(HA)-hrBR hairless guinea-pig model of human Buruli ulcer disease...
  90. ncbi Effects of growth factors on doxorubicin-induced skin necrosis: documentation of histomorphological alterations and early treatment by GM-CSF and G-CSF
    Ibrahim Vargel
    Department of Plastic and Reconstructive Surgery, Hacettepe University School of Medicine, Samanpazari 06100 Ankara, Turkey
    Ann Plast Surg 49:646-53. 2002
    ..The authors conclude that both saline and tissue growth factors (GM-CSF and G-CSF) are useful for the early treatment of doxorubicin extravasation; however, GM-CSF and G-CSF are more beneficial...
  91. ncbi [Facial localizations of Buruli ulcers: two cases]
    D Ouattara
    Service de Chirurgie Maxillo faciale, Plastique et Reconstructrice, Centre Hospitalier Intercommunal de Villeneuve Saint Georges, 40, allée de la source, 94195 Villeneuve Saint Georges
    Rev Stomatol Chir Maxillofac 104:231-4. 2003
    ..Treatment involved resection of the ulcer followed by total skin graft. Ulcer healing was observed after two months hospitalization in one patient. The other patient died...
  92. pmc Histopathologic features of Mycobacterium ulcerans infection
    Jeannette Guarner
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 9:651-656. 2003
    ..001). Defining histologic criteria for a diagnosis of Buruli ulcer disease is of clinical and public health importance since it would allow earlier treatment, leading to less deforming sequelae...
  93. ncbi Slow release iodine preparation and wound healing: in vitro effects consistent with lack of in vivo toxicity in human chronic wounds
    L H Zhou
    Department of Biochemistry, Roger Williams Medical Center, 50 Maude Street, Providence, RI 02908, USA
    Br J Dermatol 146:365-74. 2002
    ..However, there have been no studies directly assessing the potential lack of toxicity of cadexomer iodine on human cutaneous tissues...
  94. ncbi Efficacy of moist exposed burn ointment in the management of cutaneous wounds and ulcers: a multicenter pilot study
    Bishara S Atiyeh
    Ann Plast Surg 48:226-7. 2002
  95. ncbi Ultraviolet radiation enhances both the nodular and ulcerative forms of Mycobacterium ulcerans infection in a Crl:IAF(HA)-hrBR hairless guinea pig model of Buruli ulcer disease
    R B Cope
    Department of Veterinary Basic Sciences, College of Veterinary Medicine, Oregon State University, Corvalis, OR, 97331, USA
    Photodermatol Photoimmunol Photomed 18:271-9. 2002
    ..The hypothesis tested was that UV pre-exposure enhances both the nodular and ulcerative forms of M. ulcerans infection in the Crl:IAF(HA)-hrBR hairless guinea pig...
  96. ncbi [Buruli ulcer in Angolese refugees in the Kimpese area, Lower Congo, D.R. Congo]
    Kapay Kibadi
    Departement de Chirurgie, Cliniques Universitaires de Kinshasa, BP123, Kinshasa XI, RD Congo
    Sante 13:39-41. 2003
    ..All patients were infected two years before their insertion. The group most affected are children under 15 with a predominance of masculine patients. The legs were the most affected. The most frequent form is the ulcerative form...
  97. ncbi Healing of chronic cutaneous wounds by topical treatment with basic fibroblast growth factor
    Xiaobing Fu
    Wound Healing Unit, 304th Hospital, Beijing 100037, China
    Chin Med J (Engl) 115:331-5. 2002
    ..To evaluate the safety and efficacy of topical application of recombinant bovine basic fibroblast growth factor (rbFGF) on the healing of chronic cutaneous wounds...
  98. ncbi Treatment of chronic wounds with bone marrow-derived cells
    Evangelos V Badiavas
    Department of Dermatology, Boston University School of Medicine, Boston, MA, USA
    Arch Dermatol 139:510-6. 2003
    ..These patients had not previously responded to standard and advanced therapies, including bioengineered skin application and grafting with autologous skin...
  99. ncbi The clinical relevance of microbiology in acute and chronic wounds
    Maryanne McGuckin
    Department of Rehabilitation Medicine and Leonard Davis Institute of Health Economics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Adv Skin Wound Care 16:12-23; quiz 24-5. 2003
    ..2. Identify methods of debridement and wounds for which they are appropriate. 3. Identify systemic antibiotic treatment options for acute and chronic wound infections...
  100. ncbi The skin. 2. Skin and wound assessment
    Maureen Benbow
    Mid Cheshire Hospital Trust, Leighton Hospital, Cheshire
    Nurs Times 98:41-4. 2002

Research Grants16

  1. Phosphomannomutase (PMM) as a Novel Drug Target for the Parasite Leishmania
    JUSTIN WYATT; Fiscal Year: 2007
    ..The parasite Leishmania causes leishmaniasis, which is a spectrum of diseases ranging in severity from a skin ulcer to fatal visceral disease...
  2. Local Warming: Effects on Wound Infection and Healing
    JoAnne Whitney; Fiscal Year: 2007
    ..2.3. Perfusion (BF) in the surgical incision on postoperative days 3, 5 and 9 using Laser Doppler Flowmetry (LDF). ..
  3. Urinary Symptoms in Adolescent Females: STI or UTI?
    Jill Huppert; Fiscal Year: 2004
    ..The findings of this study will strengthen the evidence base for symptom-based STI testing of SA adolescent females and will promote care that addresses both individual patient and public health needs. ..
  4. Hospital Care IDUs with Soft Tissue Infections
    Traci Takahashi; Fiscal Year: 2004
    ..s. ..
  5. UV, Neuropeptides, Histamine and Buruli Ulcer Disease
    RHIAN COPE; Fiscal Year: 2005
    ..Irrespective of the outcomes of these experiments, new and important information on BUD pathogenesis will be obtained. ..
  6. Oxygen Sensitive Signaling in Primary Cardiac Fibroblast
    Chandan Sen; Fiscal Year: 2007
    ..This raises a significant broad-based issue of controlling ambient O2 during cell culture. Finally, an isolated cell culture model to study chronic moderate hypoxia followed by reoxygenation is offered. ..
  7. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  8. Clinical Epidemiology of Mycoplasma genitalium
    Patricia Totten; Fiscal Year: 2006
    ..Studies of its association with salpingitis and pregnancy morbidity are essential. Future studies should also address whether, similar to gonorrhea and chlamydial infection, it facilitates transmission of HIV infection. ..
  9. Supplemental Fluid & Collagen Deposition
    Nancy Stotts; Fiscal Year: 2005
    ..Significance: Findings from the study have the potential to significantly change how fluid is managed in nursing home residents and to lay the foundation for a major intervention study on pressure ulcer healing. ..
  10. Vaccine Induced Mucosal Protection Against TB Infection
    DANIEL HOFT; Fiscal Year: 2005
    ..Prime/boosting strategies found to prevent BCG infection after aerosol challenges will be studied for the ability to prevent infection with virulent M. tuberculosis by aerosol challenge. ..
  11. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  12. Hemolysin and Immunobiology of Chancroid
    Patricia Totten; Fiscal Year: 2004
    ..ducreyi hemolysin in the pathogenesis and immunobiology of chancroid and will provide a groundwork on which to base future strategies for vaccine development for chancroid. ..
  13. Conference--Wound Healing : O2 and Emerging Therapeutics
    Chandan Sen; Fiscal Year: 2002
    ..Oxygen Sensing Oxidant Signaling & Redox Regulated Gene Expression Oxygen Therapy of Wounds Potential and Limitations of Clinical Gene Therapy for Wound Care Wound Angiogenesis Inflammation and Bacterial Control Clinical Care ..
  14. TRYPANOSOMA CRUZI MUCOSAL & SYSTEMIC PROTECTIVE IMMUNITY
    DANIEL HOFT; Fiscal Year: 2008
    ..Chemokine and/or integrin receptor expression will be studied by flow cytometry and RT-Real-Time PCR, and the in vivo effects of defective chemokine and integrin binding and/or signaling will be evaluated. [unreadable] [unreadable]..
  15. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..