melanosis

Summary

Summary: Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.

Top Publications

  1. ncbi Congenital melanosis: an update
    Dominic F Heffel
    Department of Surgery, Division of Plastic Surgery, Miller School of Medicine at the University of Miami, USA
    J Craniofac Surg 16:940-4. 2005
  2. ncbi Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi--results from the NYU-LCMN registry
    E K Hale
    Oncology Section, Skin and Cancer Unit, New York University Medical Center, 550 First Avenue, H100, New York, NY 10016, USA
    Br J Dermatol 152:512-7. 2005
  3. ncbi Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: a study of cases from an Internet-based registry
    Anna Liza C Agero
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10022, USA
    J Am Acad Dermatol 53:959-65. 2005
  4. ncbi Mammalian melanism: natural selection in black and white
    Michael E N Majerus
    Department of Genetics, Downing Street, Cambridge CB2 3EH, UK
    Trends Genet 19:585-8. 2003
  5. ncbi Friction melanosis: a clinical, histologic, and ultrastructural study in Jordanian patients
    Mustafa Al-Aboosi
    Jordan University of Science and Technology and Yarmouk University, Irbid, Jordan
    Int J Dermatol 43:261-4. 2004
  6. ncbi [Physiopathology of melasma]
    Luciane Donida Bartoli Miot
    Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu, UNESP, SP, Brasil
    An Bras Dermatol 84:623-35. 2009
  7. ncbi Solar elastosis and presence of mast cells as key features in the pathogenesis of melasma
    R Hernández-Barrera
    Department of Dermatology, Hospital central University of San Luis Potosi, S L P, Mexico
    Clin Exp Dermatol 33:305-8. 2008
  8. ncbi Melasma in Latin America: options for therapy and treatment algorithm
    T Cestari
    University of Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Brazil
    J Eur Acad Dermatol Venereol 23:760-72. 2009
  9. ncbi Dermoscopic features of mucosal melanosis
    Francesca Mannone
    Department of Dermatology, University of Florence, Florence, Italy
    Dermatol Surg 30:1118-23. 2004
  10. ncbi Successful treatment of malar dermal melasma with a fractional ablative CO₂ laser in a patient with type V skin
    Monica R Neeley
    School of Medicine, University of Alabama at Birmingham UAB, Birmingham, AL, USA
    J Cosmet Laser Ther 12:258-60. 2010

Research Grants

  1. Microbiome-Based Risk Assessment: Reciprocal Effects of Arsenic on Environmental
    Stephanie Bachas-Daunert; Fiscal Year: 2013
  2. Selenium against arsenic toxicity and skin lesions
    JULIAN SPALLHOLZ; Fiscal Year: 2005
  3. Gene Therapy of Autosomal Recessive RP
    Simon Petersen Jones; Fiscal Year: 2006
  4. Molecular Biology of Retinoblastoma
    Daniel Albert; Fiscal Year: 2006
  5. Chemo-prevention of UVB-induced Basal Cell Carcinomas+/*
    Mohammad Athar; Fiscal Year: 2004
  6. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
  7. Role of p53 and ptc tumor suppressive pathways in BCCs development and prevention
    Mohammad Athar; Fiscal Year: 2010
  8. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2009
  9. CORE GRANT FOR VISION RESEARCH
    Herbert Kaufman; Fiscal Year: 2008
  10. Efficacy of Web-based Training in Skin Cancer Triage
    Martin Weinstock; Fiscal Year: 2007

Detail Information

Publications220 found, 100 shown here

  1. ncbi Congenital melanosis: an update
    Dominic F Heffel
    Department of Surgery, Division of Plastic Surgery, Miller School of Medicine at the University of Miami, USA
    J Craniofac Surg 16:940-4. 2005
    ..To truly obtain a current authoritative accord, a new interdisciplinary consensus conference should probably be convened to review and initiate new standards regarding available treatment modalities and their indications...
  2. ncbi Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi--results from the NYU-LCMN registry
    E K Hale
    Oncology Section, Skin and Cancer Unit, New York University Medical Center, 550 First Avenue, H100, New York, NY 10016, USA
    Br J Dermatol 152:512-7. 2005
    ....
  3. ncbi Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: a study of cases from an Internet-based registry
    Anna Liza C Agero
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10022, USA
    J Am Acad Dermatol 53:959-65. 2005
    ..We sought to determine prevalence of asymptomatic NCM, and current application of MRI as a screening tool...
  4. ncbi Mammalian melanism: natural selection in black and white
    Michael E N Majerus
    Department of Genetics, Downing Street, Cambridge CB2 3EH, UK
    Trends Genet 19:585-8. 2003
  5. ncbi Friction melanosis: a clinical, histologic, and ultrastructural study in Jordanian patients
    Mustafa Al-Aboosi
    Jordan University of Science and Technology and Yarmouk University, Irbid, Jordan
    Int J Dermatol 43:261-4. 2004
    Friction melanosis (FM) is an acquired pigmentary disorder mainly affecting young people. The primary skin regions affected are located over the osseous prominences, especially the clavicular zone and upper back...
  6. ncbi [Physiopathology of melasma]
    Luciane Donida Bartoli Miot
    Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu, UNESP, SP, Brasil
    An Bras Dermatol 84:623-35. 2009
    ..The authors discuss the main aspects associated with skin pigmentation and the development of melasma...
  7. ncbi Solar elastosis and presence of mast cells as key features in the pathogenesis of melasma
    R Hernández-Barrera
    Department of Dermatology, Hospital central University of San Luis Potosi, S L P, Mexico
    Clin Exp Dermatol 33:305-8. 2008
    ..145 +/- 57%, P = 0.04). Melasma could be a result of a cumulative sun exposure, in a microenvironment of cutaneous photoageing in which inflammatory cells, particularly mast cells, play a key role...
  8. ncbi Melasma in Latin America: options for therapy and treatment algorithm
    T Cestari
    University of Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Brazil
    J Eur Acad Dermatol Venereol 23:760-72. 2009
    ..To examine approaches to therapy for melasma in Latin Americans and to propose treatment algorithms for patients with mild, moderate and severe melasma...
  9. ncbi Dermoscopic features of mucosal melanosis
    Francesca Mannone
    Department of Dermatology, University of Florence, Florence, Italy
    Dermatol Surg 30:1118-23. 2004
    b>Melanosis (lentiginosis, labial melanotic macula) is a benign pigmented lesion of mucosa characterized by pigmentation of basal keratinocytes with melanocytic normal or slightly increased in number...
  10. ncbi Successful treatment of malar dermal melasma with a fractional ablative CO₂ laser in a patient with type V skin
    Monica R Neeley
    School of Medicine, University of Alabama at Birmingham UAB, Birmingham, AL, USA
    J Cosmet Laser Ther 12:258-60. 2010
    ..Melasma is a common disorder of hypermelanosis, and although numerous treatment modalities have been employed, many cases are refractory to treatment or the improvement after therapy is temporary...
  11. ncbi Treatment of melasma using variable square pulse Er:YAG laser resurfacing
    Rungsima Wanitphakdeedecha
    Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Dermatol Surg 35:475-81; discussion 481-2. 2009
    ..Recently, variable-pulsed erbium:yttrium aluminum garnet (Er:YAG) lasers have shown favorable results in skin resurfacing, with minimal downtime and adverse effects...
  12. ncbi Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years' experience
    Madhavi Kurli
    The New York Eye Cancer Center, The Fifth Floor, 115 East 61st Street, New York, NY 10021, USA
    Graefes Arch Clin Exp Ophthalmol 243:1108-14. 2005
    To report 12-year follow-up experience with topical mitomycin chemotherapy for diffuse and multifocal primary acquired melanosis (PAM) with atypia and conjunctival melanoma.
  13. ncbi Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli
    Zhong Chuan Wang
    Department of Anorectal Surgery and Colorectal Cancer Center, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Dig Dis 14:417-24. 2013
    To determine the hedgehog (Hh) signaling pathway correlated with the development of colon cancer and melanosis coli.
  14. ncbi Neurocutaneous melanosis in association with Dandy-Walker malformation: case report and literature review
    S Schreml
    Dermatological Outpatient Facility, Regensburg, Germany
    Clin Exp Dermatol 33:611-4. 2008
    Neurocutaneous melanosis (NCM) is a rare congenital noninheritable phacomatosis characterized by large and/or numerous cutaneous congenital melanocytic naevi (CMN) in combination with melanocytic leptomeningeal tumours...
  15. ncbi Pseudomelanosis of stomach, duodenum, and jejunum
    Leonard B Weinstock
    Washington University Medical Center, St Louis, Missouri, USA
    Gastrointest Endosc 58:578. 2003
  16. ncbi Combined ultrapulse CO2 laser and Q-switched alexandrite laser compared with Q-switched alexandrite laser alone for refractory melasma: split-face design
    Suhattaya Angsuwarangsee
    Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Dermatol Surg 29:59-64. 2003
    ..To date, the mainstay of treatment, including various hypopigmenting agents and chemical peels, is ineffective and can cause adverse effects. Laser is a new approach and is yet to be explored for its efficacy and safety...
  17. ncbi Histologic and ultrastructural analysis of melasma after fractional resurfacing
    David J Goldberg
    Skin Laser and Surgery Specialists of NY NJ, New York, New York, USA
    Lasers Surg Med 40:134-8. 2008
    ..Recently, successful improvement in melasma has been achieved with this laser system. We undertook this study to evaluate the ultrastructural changes associated with fractional laser treatment of melasma...
  18. pmc The genetic basis of adaptive melanism in pocket mice
    Michael W Nachman
    Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 100:5268-73. 2003
    ..Interestingly, another melanic population of these mice on a different lava flow shows no association with Mc1r mutations, indicating that adaptive dark color has evolved independently in this species through changes at different genes...
  19. ncbi The treatment of melasma with topical creams alone, CO2 fractional ablative resurfacing alone, or a combination of the two: a comparative study
    Mario A Trelles
    Instituto Medico Vilafortuny, Antoni de Gimbernat Foundation, Cambrils, Spain
    J Drugs Dermatol 9:315-22. 2010
    ..This three-armed study compares topical creams, CO2 ablative fractional resurfacing and the combination of both modalities...
  20. ncbi Spectrum of central nervous system abnormalities in neurocutaneous melanocytosis
    Vijay Ramaswamy
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Dev Med Child Neurol 54:563-8. 2012
    ..We sought to define the spectrum of central nervous system abnormalities in children with neurocutaneous melanocytosis...
  21. ncbi The treatment of melasma with fractional photothermolysis: a pilot study
    Cameron K Rokhsar
    Department of Dermatology, Albert Einstein College of Medicine, Bronx, NY, USA
    Dermatol Surg 31:1645-50. 2005
    ..Melasma is a common pigmentary disorder that remains resistant to available therapies. Facial resurfacing with the pulsed CO2 laser has been reported successful but requires significant downtime, and there is a risk of adverse sequelae...
  22. ncbi Neurocutaneous melanosis in a newborn with giant congenital melanocytic nevus
    P David
    Department of Neuroradiology, Erasmus Hospital ULB, Brussels, Belgium, and Department of Clinical Physiopathology, Radiodiagnostic Section, University of Florence, Florence, Italy
    J Neuroradiol 34:272-5. 2007
    Neurocutaneous melanosis (NCM) is known as a rare phakomatose characterised by large or numerous pigmented congenital nevi associated with leptomeninges melanin-containing deposits...
  23. pmc Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS
    Veronica A Kinsler
    Paediatric Dermatology Department, Great Ormond Street Hospital for Children, London, UK
    J Invest Dermatol 133:2229-36. 2013
    ..These results suggest that single postzygotic NRAS mutations are responsible for multiple CMN and associated neurological lesions in the majority of cases. ..
  24. ncbi Utilizing fractional resurfacing in the treatment of therapy-resistant melasma
    Zeina S Tannous
    Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Cosmet Laser Ther 7:39-43. 2005
    ..Multiple treatment modalities have been employed for the management of melasma with minimal to no success...
  25. ncbi Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosis
    H Takayama
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    J Am Acad Dermatol 44:538-40. 2001
    ..pigmented nevi in both skin and leptomeninges of the central nervous system resembling human neurocutaneous melanosis. We immunohistochemically detected HGF/SF receptor, Met, in a congenital nevus of an infant with neurocutaneous ..
  26. pmc Exclusion of eleven candidate genes for ocular melanosis in Cairn terriers
    Paige A Winkler
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
    J Negat Results Biomed 12:6. 2013
    Ocular melanosis of Cairn terrier dogs is an inherited defect characterized by progressive pigmentation of both eyes which can result in glaucoma and blindness...
  27. ncbi Pseudomelanosis ilei associated with ingestion of charcoal: case report and review of literature
    Juhyung Kim
    Department of Gastroenterology, Korea University Guro Hospital, Seoul, Korea
    Dig Endosc 22:56-8. 2010
    b>Melanosis or pseudomelanosis of the gastrointestinal tract refers to an accumulation of pigment deposits in the gastrointestinal mucosa. Pigmentation can affect the entire gastrointestinal tract...
  28. ncbi Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic children
    R D Foster
    Division of Plastic and Reconstructive Surgery, Department of Dermatology, University of California, San Francisco, USA
    Plast Reconstr Surg 107:933-41. 2001
    ..characterized by central nervous system involvement, termed leptomeningeal melanocytosis or neurocutaneous melanosis. Although symptomatic neurocutaneous melanosis is rare, we previously reported distinct magnetic resonance (MR) ..
  29. ncbi [Neurocutaneous melanosis]
    M A Martínez-Granero
    Servicio de Neurologia Infantil, Hospital Infantil La Paz, Madrid, Espana
    Rev Neurol 25:S265-8. 1997
    Neurocutaneous melanosis is a sporadic neurocutaneous syndrome characterized by the presence of giant or multiple melanocytic nevi and excessive proliferation of melanotic cells in the central nervous system...
  30. ncbi Ocular melanosis in the Cairn Terrier: histopathological description of the condition, and immunohistological and ultrastructural characterization of the characteristic pigment-laden cells
    Simon M Petersen-Jones
    Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA
    Vet Ophthalmol 11:260-8. 2008
    To describe the microscopic features and lineage of proliferating/infiltrating pigmented cells in ocular melanosis of Cairn Terriers...
  31. ncbi The epidemiology of nevi and signs of skin aging in the adult general population: Results of the KORA-survey 2000
    Torsten Schafer
    Institute of Social Medicine, Medical University of Luebeck, Luebeck, Germany
    J Invest Dermatol 126:1490-6. 2006
    ..In contrast, common and atypical nevi and ephelides decreased significantly with age. Signs of skin aging are frequent and increase, in contrast to common and atypical nevi, with age...
  32. ncbi Prevalence and familial risk of ephelides in Han Chinese adolescents
    Sen Yang
    Department of Dermatology, The First Hospital, Institute of Dermatology, Anhui Medical University, Hefei, Anhui, People s Republic of China
    Arch Dermatol Res 300:87-90. 2008
    ..61-7.18, P < 0.001). Our study provided the first information on the prevalence of ephelides in Chinese adolescents and suggests that familial factors are important in determining individual susceptibility to ephelides...
  33. ncbi The risk of melanoma and neurocutaneous melanosis associated with congenital melanocytic nevi
    Kara N Shah
    The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Semin Cutan Med Surg 29:159-64. 2010
    ..the context of multiple satellite melanocytic nevi, are also associated with the development of neurocutaneous melanosis, which may result in neurologic and neurodevelopmental sequelae and is associated with a significant risk of ..
  34. ncbi Ocular melanosis in the Cairn Terrier: clinical description and investigation of mode of inheritance
    Simon M Petersen-Jones
    Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824 1314, USA
    Vet Ophthalmol 10:63-9. 2007
    To describe the clinical features of ocular melanosis in Cairn Terriers.
  35. ncbi Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and staging
    Bertil Damato
    Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
    Clin Experiment Ophthalmol 36:786-95. 2008
    This paper aims to stimulate debate on the terminology, classification, grading and staging of conjunctival melanosis and melanoma. We audited our results with 76 invasive conjunctival melanomas...
  36. pmc Amniotic membrane transplantation in the management of conjunctival malignant melanoma and primary acquired melanosis with atypia
    D Paridaens
    Rotterdam Eye Hospital, Oculoplastic Service, Rotterdam Eye Hospital, The Netherlands
    Br J Ophthalmol 85:658-61. 2001
    ..membrane transplantation (AMT) for the management of conjunctival malignant melanoma and primary acquired melanosis (PAM) with atypia...
  37. ncbi Frictional dermal melanosis (lifa disease) over bony prominences
    K E Sharquie
    Department of Dermatology, College of Medicine, University of Baghdad, Iraq
    J Dermatol 28:12-5. 2001
    ..The histopathology of biopsies from 24 patients showed marked dermal melanosis. Amyloid deposits in the papillary dermis were present in one patient...
  38. ncbi Subclinical speckled perifollicular melanosis of the scalp
    Ludivine Petit
    Department of Dermatopathology, University Medical Center Sart Tilman and Sauvenière, B 4000 Liege, Belgium
    Eur J Dermatol 12:565-8. 2002
    ..It is concluded that the perifollicular subclinical melanotic pattern is a regional characteristic of cephalic skin, perhaps related to the local production of melanocortins, particularly alpha-MSH by the pilosebaceous unit...
  39. doi Melanosis of the areola and nipple
    Jennifer A Sceppa
    J Am Acad Dermatol 59:S33-4. 2008
  40. ncbi Neurocutaneous melanosis presenting with hydrocephalus. Case report and review of the literature
    Frank L Acosta
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 102:96-100. 2005
    Neurocutaneous melanosis (NCM) is a rare congenital neurocutaneous syndrome characterized by large or multiple congenital melanocytic nevi and benign or malignant melanocytic tumors of the leptomeninges...
  41. ncbi Diffuse melanosis after chemotherapy-induced tumor lysis syndrome in a patient with metastatic melanoma
    Klaus J Busam
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cutan Pathol 31:274-80. 2004
    Diffuse melanosis is a rare event associated with advanced metastatic malignant melanoma...
  42. ncbi The treatment of melasma: a review of clinical trials
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site and the University of Toronto, Ontario, Canada
    J Am Acad Dermatol 55:1048-65. 2006
    ..Chemical peels, laser treatments, and intense pulsed light therapy are additional therapeutic modalities that have been used to treat melasma...
  43. ncbi Melasma: histopathological characteristics in 56 Korean patients
    W H Kang
    Departments of Dermatology and Pathology, and Laboratory of Cell Biology, Institute for Medical Sciences, Ajou University School of Medicine, 5 Wonchon dong, Paldal Ku, Suwon 442 721, Korea
    Br J Dermatol 146:228-37. 2002
    ..Melasma is a common acquired symmetrical hypermelanosis characterized by irregular light to dark brown macules and patches on sun-exposed areas of the skin. Its histopathological characteristics are not fully understood...
  44. pmc Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism mutant
    Fang yin Dai
    College of Biotechnology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400715, China
    J Biol Chem 285:19553-60. 2010
    ..To our knowledge, this is the first report showing a role for arylalkylamine-N-acetyltransferases in color pattern mutation in Lepidoptera...
  45. ncbi Recent history of melanism in American peppered moths
    B S Grant
    Department of Biology, College of William and Mary, Williamsburg, VA 23187 8795, USA
    J Hered 93:86-90. 2002
    ..We contrast these changes to the near absence of melanism in a southern state-Virginia-during that same period. As in Britain, the decline in melanism in American peppered moths followed clean air legislation...
  46. ncbi [Neurocutaneous melanosis]
    S Diaz-Insa
    Servicio de Neurologia, Hospital Sant Joan de Deu, Barcelona, Espana
    Rev Neurol 26:769-71. 1998
    Neurocutaneous melanosis is an infrequent condition characterized by the presence of numerous gigantic cutaneous naevi and melanocytic infiltration of the central nervous system and/or the leptomeningeal layers...
  47. ncbi Neurocutaneous melanosis
    F Di Rocco
    Section of Pediatric Neurosurgery, Institute of Neurosurgery, Catholic University Medical School, Largo Gemelli 8, 00168, Rome, Italy
    Childs Nerv Syst 20:23-8. 2004
    Neurocutaneous melanosis (NCM) is a rare phakomatosis characterized by a focal or diffuse proliferation of melanin-producing cells in both the skin and the leptomeninges...
  48. ncbi Neurocutaneous melanosis in association with the Dandy-Walker complex
    J N Kadonaga
    Department of Dermatology, Oregon Health Sciences University, Portland
    Pediatr Dermatol 9:37-43. 1992
    An infant had a giant congenital nevus, neurocutaneous melanosis (NCM), and a Dandy-Walker malformation of the brain...
  49. ncbi Multiple giant congenital melanocytic nevi with central nervous system melanosis
    S R Ahuja
    Division of Pediatric Neurology, Department of Pediatrics, LTM Medical College and LTMG Hospital, Sion, Mumbai 400022, India
    Neurol India 51:541-3. 2003
    A case of multiple giant congenital melanocytic naevi in whom central nervous system melanosis was detected at 6 weeks of age is described...
  50. ncbi Neurocutaneous melanosis in association with the Dandy-Walker complex, complicated by melanoma: report of a case and literature review
    Carlos Alfredo Mena-Cedillos
    Department of Dermatology, Federico Gómez Children s Hospital of México, Mexico City, Mexico
    Pediatr Dermatol 19:237-42. 2002
    Neurocutaneous melanosis is a rare congenital neurocutaneous syndrome in which benign and malignant melanocytic tumors of the leptomeninges with large or numerous congenital melanocytic nevi develop...
  51. ncbi Neurocutaneous melanosis with associated Dandy-Walker complex
    Adrian Caceres
    Neurosurgery Division, Children s Memorial Hospital, 2300 Children s Plaza, P O Box 28, Chicago, IL, USA
    Childs Nerv Syst 22:67-72. 2006
    The authors report the case of a child with neurocutaneous melanosis associated with a Dandy-Walker complex...
  52. ncbi Melanosis of the colon and terminal ileum associated with primary malignant melanoma of the anorectum
    Seong Soo Hong
    Department of Internal Medicine, Dongguk University International Hospital, Goyang, Gyeonggi, Korea
    Gastrointest Endosc 63:886-8. 2006
  53. ncbi Melasma: a review
    Frank C Victor
    Robert Wood Johnson University Hospital, New Brunswick, New Jersey, USA
    J Cutan Med Surg 8:97-102. 2004
    ..To better understand melasma, a review of its etiologic factors, classification, pathogenesis, and treatment was undertaken...
  54. ncbi Cerebral mass due to neurocutaneous melanosis: eight years later
    J V Schaffer
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Pediatr Dermatol 18:369-77. 2001
    Neurocutaneous melanosis (NCM) is associated most commonly with giant congenital melanocytic nevi (CMN), in particular those on the scalp or in a posterior axial location that are accompanied by satellite congenital nevi...
  55. ncbi MR Imaging of pial melanosis secondary to a posterior fossa melanotic ependymoma
    Sait Albayram
    Division of Neuroradiology, Department of Radiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
    AJNR Am J Neuroradiol 26:804-8. 2005
    ..There was no evidence of hemosiderin in tumor cells and in interstitial spaces. Pial melanin accumulation secondary to a posterior fossa melanotic ependymoma explained our MR findings...
  56. doi Dermoscopy identifies histopathologically indiscernible malignant lesion of atypical melanosis of the foot, an early lesion of acral lentiginous melanoma in situ
    Hsiu Hui Chiu
    Department of Dermatology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Dermatol Surg 34:979-83. 2008
  57. ncbi Primary acquired melanosis of the conjunctiva: risks for progression to melanoma in 311 eyes. The 2006 Lorenz E. Zimmerman lecture
    Jerry A Shields
    Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Ophthalmology 115:511-519.e2. 2008
    To evaluate the clinical features and risks for transformation of conjunctival primary acquired melanosis (PAM) into melanoma.
  58. doi Melanosis ilei associated with chronic ingestion of edible charcoal
    Tae Hoon Lee
    Division of Gastroenterology, Department of Internal Medicine, University of Soonchunhyang College of Medicine, Cheonan Hospital, Cheonan, Korea
    Gastrointest Endosc 67:1174; discussion 1175. 2008
  59. ncbi Neurocutaneous melanosis
    Hanspaul S Makkar
    Department of Dermatology and Pediatrics, University of California, San Francisco, CA, USA
    Semin Cutan Med Surg 23:138-44. 2004
    Neurocutaneous melanosis (NCM) is a rare congenital disorder characterized by the presence of large or multiple congenital melanocytic nevi in association with benign or malignant proliferation of melanocytes in the leptomeninges...
  60. ncbi Constipation, anthranoid laxatives, melanosis coli, and colon cancer: a risk assessment using aberrant crypt foci
    Riccardo Nascimbeni
    Cattedra di Chirurgia Generale, University of Brescia, 25124 Brescia, Italy
    Cancer Epidemiol Biomarkers Prev 11:753-7. 2002
    The associations between colorectal cancer (CRC) and constipation, anthranoid laxative use, and melanosis coli are controversial...
  61. ncbi Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: review of the evidence and recommendations for treatment
    Rajeev Chalasani
    Ocular Oncology Unit, Save Sight Institute, Sydney Eye Hospital, Sydney, New South Wales, Australia
    Clin Experiment Ophthalmol 34:708-14. 2006
    ..excision with cryotherapy is a well-established treatment option for malignant melanoma or primary acquired melanosis (PAM) with atypia of the conjunctiva and cornea...
  62. ncbi A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma
    Liliana Elizabeth Espinal-Perez
    Department of Dermatology, Hospital Central, University of San Luis Potosi, Mexico
    Int J Dermatol 43:604-7. 2004
    ..Melasma is an acquired treatment-resistant hyperpigmentation of the skin...
  63. ncbi Melanosis of the bladder: a rare endoscopic and histopathological finding
    F Di Fiore
    Department of Urology, Monaldi Hospital, Naples, Italy
    Urol Int 78:185-7. 2007
    b>Melanosis of the bladder represents a rare condition characterized by anomalous deposits of melanin-containing pigment. To our knowledge, so far, just 5 cases have been reported in the literature...
  64. doi Primary malignant melanoma of the rectum arising against a background of rectal melanosis
    Alberto Righi
    Centro Consulenze Anatomia Patologica Oncologica, Centro Diagnostico Italiano, Milan, Italy
    Int J Surg Pathol 16:335-6. 2008
  65. ncbi [Melanosis of the urinary bladder--a case report with 10 years of follow-up and review of literature]
    P F Engelhardt
    Abteilung für Urologie, Thermenklinikum Baden, Osterreich
    Aktuelle Urol 37:222-4. 2006
    ..We report for the first time a case of solitary melanosis of the urinary bladder with a follow-up of more than 10 years.
  66. ncbi Different genes underlie adaptive melanism in different populations of rock pocket mice
    H E Hoekstra
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Mol Ecol 12:1185-94. 2003
    ..These results indicate that adaptive melanism has arisen at least twice in C. intermedius and that these similar phenotypic changes have a different genetic basis...
  67. ncbi The treatment of primary acquired melanosis (PAM) with atypia by topical Mitomycin C
    Jacob Pe'er
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, 91120 Jerusalem, Israel
    Am J Ophthalmol 139:229-34. 2005
    To report our results of 12 consecutive patients with conjunctival primary acquired melanosis (PAM) with atypia who were treated by topical Mitomycin C (MMC).
  68. ncbi Anthranoid self-medication causing rapid development of melanosis coli
    M Willems
    Department of Gastroenterology and Hepatology Ca 415, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Neth J Med 61:22-4. 2003
    It is widely known that long-term use of anthranoid-containing laxatives is the cause of melanosis coli...
  69. ncbi Topical interferon alfa in the treatment of conjunctival melanoma and primary acquired melanosis complex
    Paul T Finger
    The New York Eye Cancer Center, New York, New York 10065, USA
    Am J Ophthalmol 145:124-129. 2008
    To report on topical interferon alfa-2b for conjunctival malignant melanoma (CMM) and primary acquired melanosis with atypia (PAM).
  70. pmc Melanism in peromyscus is caused by independent mutations in agouti
    Evan P Kingsley
    Department of Organismic and Evolutionary Biology and The Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 4:e6435. 2009
    ..These results show that melanism has evolved independently in these populations through mutations in the same gene, and suggest that melanism produced by mutations in genes other than Mc1r may be more common than previously thought...
  71. ncbi Low-risk and high-risk histologic features in conjunctival primary acquired melanosis with atypia: Clinicopathologic analysis of 29 cases
    Mitsuhiro Sugiura
    Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 31:185-92. 2007
    ..conjunctival proliferations are included in a heterogeneous category designated as primary acquired melanosis (PAM) with atypia. We performed clinicopathologic analysis of 29 cases of PAM with atypia...
  72. ncbi An unusual case of neurocutaneous melanosis
    Daniela Oliveira de Andrade
    Setor de Neurofisiologia Clinica, Hôpital Sarah, Salvador BA, Brazil
    Epileptic Disord 6:145-52. 2004
    The neurocutaneous melanosis (NCM) is a rare, neuroectodermal dysplasia defined by the association of giant or multiple, nonmalignant pigmented cutaneous nevi with leptomeningeal melanosis or melanoma...
  73. ncbi Neurocutaneous melanosis and epilepsy surgery
    Frederick Andermann
    Epileptic Disord 7:57. 2005
  74. ncbi Secretion of arsenic, cholesterol, vitamin E, and zinc from the site of arsenical melanosis and leucomelanosis in skin
    A K M Yousuf
    Division of Arsenic Research, Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahba, Dhaka, Bangladesh
    Clin Toxicol (Phila) 49:374-8. 2011
    b>Melanosis and leucomelanosis with or without keratosis are the earliest symptoms of arsenicosis...
  75. ncbi Atypical melanosis of the foot showing a dermoscopic feature of the parallel ridge pattern
    Isil Kilinc Karaarslan
    Department of Dermatology, Ege University Medical Faculty, Izmir, Turkey
    J Dermatol 34:56-9. 2007
    ..There was no sign of regression such as fibrous tissue or host reaction. Atypical melanosis of the foot has rarely been reported in the published work, which are from Japan and Korea...
  76. ncbi Melanosis coli involving pericolonic lymph nodes associated with the herbal laxative Swiss Kriss: a rare and incidental finding in a patient with colonic adenocarcinoma
    C Alexander Ewing
    Department of Pathology, Georgetown University Hospital, Washington, DC 20007, USA
    Arch Pathol Lab Med 128:565-7. 2004
    b>Melanosis coli is a well-known condition in which macrophages filled with a lipofuscin-like pigment are found in the colonic lamina propria...
  77. ncbi Prevalence and awareness of melasma during pregnancy
    Athar Moin
    Department of Dermatology, Faculty of Medicine, Shahed University, Tehran, Iran
    Int J Dermatol 45:285-8. 2006
    ..There is little information on its prevalence during pregnancy in Iran. Objective To determine the prevalence and awareness of melasma during pregnancy at the Shahed University Hospitals of Tehran, Iran...
  78. pmc "Melanosis" in the small and large intestine
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:4296-9. 2008
    ..Pigment may also be detected in the small intestine. Although labeled as melanosis, electron microscopy and X-ray analytical methods have provided evidence that this pigment is not melanin at all,..
  79. ncbi Application of computerized image analysis in pigmentary skin diseases
    E S Lee
    Department of Dermatology, and Laboratory of Cell Biology, Ajou University School of Medicine and Institute for Medical Sciences, Suwon, Korea
    Int J Dermatol 40:45-9. 2001
    ....
  80. ncbi Isolated choroidal melanocytosis: a distinct clinical entity?
    James J Augsburger
    Department of Ophthalmology, Health Professions Building, Suite 350, 3223 Eden Avenue, Cincinnati, OH 45267 0527, USA
    Graefes Arch Clin Exp Ophthalmol 244:1522-7. 2006
    ..The objective was to describe a distinct, limited form of congenital ocular melanocytosis that involves the choroid only...
  81. ncbi Clinical, dermoscopy and histological correlation study of melanotic pigmentations in excision scars of melanocytic tumours
    R Botella-Estrada
    Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain
    Br J Dermatol 154:478-84. 2006
    ..Recurrent naevi may sometimes adopt unusual features that make them difficult to differentiate from a melanoma...
  82. ncbi Neurocutaneous melanosis: clinical presentations
    Christina M Plikaitis
    Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27175 1075, USA
    J Craniofac Surg 16:921-5. 2005
  83. ncbi Esophageal melanocytosis morphologic features and review of the literature
    Fuju Chang
    Department of Histopathology, St Thomas Hospital, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
    Arch Pathol Lab Med 130:552-7. 2006
    ..Following a search of the bibliographic databases (PubMed and Medline) regarding esophageal melanocytosis and melanosis, thirty-four cases of isolated esophageal melanocytosis (including one unpublished case from us) were found...
  84. ncbi Melanocytic nevi: challenging clinical situations in pediatric dermatology
    Albert C Yan
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Adv Dermatol 21:65-80. 2005
  85. ncbi In vivo confocal microscopy of pigmented conjunctival tumors
    Elisabeth M Messmer
    Department of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, 80336 Munich, Germany
    Graefes Arch Clin Exp Ophthalmol 244:1437-45. 2006
    ..To analyze the appearance of conjunctival pigmented tumors as seen by in vivo confocal microscopy...
  86. ncbi Neurocutaneous melanosis: an atypical presentation
    Siddharth Khera
    Department of Dermatology and Venereology, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India
    J Dermatol 32:602-5. 2005
    ..Clinically and histologically, the diagnosis was suggestive of neurocutaneous melanosis (NCM)...
  87. ncbi Melanotic macule of nail unit and its clinicopathologic spectrum
    Sameera Husain
    College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Am Acad Dermatol 54:664-7. 2006
    ..This underscores the importance of obtaining a biopsy of the nail matrix in patients who present with solitary longitudinal melanonychia...
  88. ncbi Predictive value of exfoliative cytology in pigmented conjunctival lesions
    Sander Keijser
    Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands
    Acta Ophthalmol Scand 84:188-91. 2006
    ..Exfoliative cytology may be helpful, but reliable data regarding the sensitivity and specificity of this test are currently lacking. We determined the value of exfoliative cytology with regard to pigmented conjunctival lesions...
  89. ncbi SCALP syndrome: sebaceous nevus syndrome, CNS malformations, aplasia cutis congenita, limbal dermoid, and pigmented nevus (giant congenital melanocytic nevus) with neurocutaneous melanosis: a distinct syndromic entity
    Joseph Lam
    Rady Children s Hospital, San Diego, California, USA
    J Am Acad Dermatol 58:884-8. 2008
    ....
  90. ncbi Impression cytology of melanocytic conjunctival tumours using the Biopore membrane
    S Keijser
    Department of Ophthalmology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
    Eur J Ophthalmol 17:501-6. 2007
    ..To compare a new Biopore membrane impression cytology method with the routinely used exfoliative cytology in patients with a melanocytic lesion of the conjunctiva...
  91. ncbi Giant congenital melanocytic nevi
    Jugpal S Arneja
    Section of Plastic Surgery, Children s Hospital of Michigan and Wayne State University, Detroit, MI, USA
    Plast Reconstr Surg 120:26e-40e. 2007
    ..2. Know the natural history and potential complications associated with a giant congenital melanocytic nevus. 3. Outline the nonsurgical and surgical options available to treat a giant congenital melanocytic nevus...
  92. ncbi Three unusual neuropathologic-related causes of sudden death
    Dennis J Chute
    Dutchess County Medical Examiner s Office, 387 Main Street, Poughkeepsie, NY 12601, USA
    J Forensic Sci 53:734-8. 2008
    ..man who died of a seizure due to malignant melanoma of the temporal lobe associated with neurocutaneous melanosis (NCM)...
  93. ncbi Neurocutaneous melanosis associated with autoimmune diabetes mellitus
    Kevin R Joseph
    Child Neurology Section, Madigan Army Medical Center, Tacoma, WA, USA
    Neurology 68:1862-3. 2007
  94. ncbi Large primary meningeal melanoma in an adult patient with neurocutaneous melanosis
    Felix Kiecker
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Clin Neurol Neurosurg 109:448-51. 2007
    Neurocutaneous melanosis is often associated with melanoma of the central nervous system. Due to the inconspicuously looking cutaneous melanosis additional examinations are often not performed...
  95. ncbi [Neurocutaneous melanosis--case report]
    Justyna Paprocka
    Kliniki Pediatrii i Neurologii Wieku Rozwojowego Katedry Pediatrii, Slaskiej Akademii Medycznej w Katowicach
    Wiad Lek 57:520-3. 2004
    ..Magnetic resonance imaging (MRI) of the head performed at the age of 2 months showed melanin deposits in the temporal lobes. The diagnosis of neurocutaneous melanosis was made on the basis of clinical picture.
  96. ncbi Sudden change of a large congenital melanocytic nevus to neurocutaneous melanosis
    Choong Jae Lee
    Department of Plastic and Reconstructive Surgery, College of Medicine, Inha University, Incheon, South Korea
    J Craniofac Surg 17:1216-8. 2006
    Neurocutaneous melanosis (NCM) is a congenital phakomatosis in which large congenital melanocytic nevi are associated with a benign or malignant melanocytic tumor of the leptomeninges...
  97. ncbi [Pigmented vulvar lesions]
    C Renaud-Vilmer
    Spécialiste des centres anticancéreux, Centre Rene Huguenin, 25, rue Dailly, 92210 Saint Cloud, France
    Ann Dermatol Venereol 133:717-23. 2006
  98. ncbi Appearance of melanocytic nevi on the backs of young Australian children: a 7-year longitudinal study
    Elizabeth Milne
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, West Perth, Australia
    Melanoma Res 18:22-8. 2008
    ..Longitudinal studies have important advantages over cross-sectional studies in the description of nevus development with age, and should be the preferred study design...
  99. ncbi Tumoral melanosis as a manifestation of a completely regressed primary melanoma with metastases
    S H Ng
    Br J Dermatol 155:627-8. 2006
  100. ncbi Acute kidney injury in a patient with melanuria, diffuse melanosis, and metastatic malignant melanoma
    Thilo Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Am J Clin Dermatol 9:267-70. 2008
    Diffuse melanosis with melanuria is a rare complication of metastatic malignant melanoma that is associated with a very poor prognosis. Acute kidney injury secondary to melanuria has not been reported previously...
  101. ncbi Repeated treatment protocols for melasma and acquired dermal melanocytosis
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo, School of Medicine, Tokyo, Japan
    Dermatol Surg 32:365-71. 2006
    ..Melasma and acquired dermal melanocytosis (ADM; acquired bilateral nevus of Ota-like macules) are both seen most commonly symmetrically on the face of women with darker skin and are also known as difficult conditions to treat...

Research Grants13

  1. Microbiome-Based Risk Assessment: Reciprocal Effects of Arsenic on Environmental
    Stephanie Bachas-Daunert; Fiscal Year: 2013
    ..Chronic exposure leads to arsenicosis, which includes melanosis, keratosis, as well as lung, bladder, kidney, and skin cancer...
  2. Selenium against arsenic toxicity and skin lesions
    JULIAN SPALLHOLZ; Fiscal Year: 2005
    ..Background: Arsenicosis in children and adults is characterized by 1) melanosis on hands and trunk, 2) palmar-plantar hyperkeratosis, 3) basal and squamous cell carcinomas, and 4) various ..
  3. Gene Therapy of Autosomal Recessive RP
    Simon Petersen Jones; Fiscal Year: 2006
    ..abstract_text> ..
  4. Molecular Biology of Retinoblastoma
    Daniel Albert; Fiscal Year: 2006
    ..Lastly the potency of the 19-nor compounds wil be compared to standard chemotherapy and their possible synergistic effect in multi-drug treatment established. ..
  5. Chemo-prevention of UVB-induced Basal Cell Carcinomas+/*
    Mohammad Athar; Fiscal Year: 2004
    ....
  6. OCULAR MELANOMA
    Paul Finger; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  7. Role of p53 and ptc tumor suppressive pathways in BCCs development and prevention
    Mohammad Athar; Fiscal Year: 2010
    ....
  8. THE ROLE OF RB IN THE RETINA & OTHER TISSUES
    JAMES HARBOUR; Fiscal Year: 2009
    ..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. ..
  9. CORE GRANT FOR VISION RESEARCH
    Herbert Kaufman; Fiscal Year: 2008
    ..This Core Grant has [unreadable] been a vital force in keeping vision research highly active at LSU for the past 25 years, and we hope that it will continue to serve this function in the future. [unreadable] [unreadable]..
  10. Efficacy of Web-based Training in Skin Cancer Triage
    Martin Weinstock; Fiscal Year: 2007
    ..If this course is found to be efficacious, it will be made freely available on the web, and we will plan efforts to encourage its broad dissemination. [unreadable] [unreadable]..
  11. SKIN SELF EXAMINATION FOR EARLY DETECTION OF MELANOMA
    Martin Weinstock; Fiscal Year: 2002
    ..The knowledge and experiment thus gained will aid the continuing efforts to encourage SSE and reduce melanoma mortality. ..
  12. Effect of vertebral endplate composition on disc health
    Frank Acosta; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGE
    Henry Mankin; Fiscal Year: 2001
    ..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..