Genomes and Genes
Summary: Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.
Publications220 found, 100 shown here
- Congenital melanosis: an updateDominic F Heffel
Department of Surgery, Division of Plastic Surgery, Miller School of Medicine at the University of Miami, USA
J Craniofac Surg 16:940-4. 2005..To truly obtain a current authoritative accord, a new interdisciplinary consensus conference should probably be convened to review and initiate new standards regarding available treatment modalities and their indications...
- Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi--results from the NYU-LCMN registryE K Hale
Oncology Section, Skin and Cancer Unit, New York University Medical Center, 550 First Avenue, H100, New York, NY 10016, USA
Br J Dermatol 152:512-7. 2005....
- Asymptomatic neurocutaneous melanocytosis in patients with large congenital melanocytic nevi: a study of cases from an Internet-based registryAnna Liza C Agero
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10022, USA
J Am Acad Dermatol 53:959-65. 2005..We sought to determine prevalence of asymptomatic NCM, and current application of MRI as a screening tool...
- Mammalian melanism: natural selection in black and whiteMichael E N Majerus
Department of Genetics, Downing Street, Cambridge CB2 3EH, UK
Trends Genet 19:585-8. 2003
- Friction melanosis: a clinical, histologic, and ultrastructural study in Jordanian patientsMustafa Al-Aboosi
Jordan University of Science and Technology and Yarmouk University, Irbid, Jordan
Int J Dermatol 43:261-4. 2004Friction melanosis (FM) is an acquired pigmentary disorder mainly affecting young people. The primary skin regions affected are located over the osseous prominences, especially the clavicular zone and upper back...
- [Physiopathology of melasma]Luciane Donida Bartoli Miot
Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu, UNESP, SP, Brasil
An Bras Dermatol 84:623-35. 2009..The authors discuss the main aspects associated with skin pigmentation and the development of melasma...
- Solar elastosis and presence of mast cells as key features in the pathogenesis of melasmaR Hernández-Barrera
Department of Dermatology, Hospital central University of San Luis Potosi, S L P, Mexico
Clin Exp Dermatol 33:305-8. 2008..145 +/- 57%, P = 0.04). Melasma could be a result of a cumulative sun exposure, in a microenvironment of cutaneous photoageing in which inflammatory cells, particularly mast cells, play a key role...
- Melasma in Latin America: options for therapy and treatment algorithmT Cestari
University of Rio Grande do Sul, Hospital de Clinicas de Porto Alegre, Brazil
J Eur Acad Dermatol Venereol 23:760-72. 2009..To examine approaches to therapy for melasma in Latin Americans and to propose treatment algorithms for patients with mild, moderate and severe melasma...
- Dermoscopic features of mucosal melanosisFrancesca Mannone
Department of Dermatology, University of Florence, Florence, Italy
Dermatol Surg 30:1118-23. 2004b>Melanosis (lentiginosis, labial melanotic macula) is a benign pigmented lesion of mucosa characterized by pigmentation of basal keratinocytes with melanocytic normal or slightly increased in number...
- Successful treatment of malar dermal melasma with a fractional ablative CO₂ laser in a patient with type V skinMonica R Neeley
School of Medicine, University of Alabama at Birmingham UAB, Birmingham, AL, USA
J Cosmet Laser Ther 12:258-60. 2010..Melasma is a common disorder of hypermelanosis, and although numerous treatment modalities have been employed, many cases are refractory to treatment or the improvement after therapy is temporary...
- Treatment of melasma using variable square pulse Er:YAG laser resurfacingRungsima Wanitphakdeedecha
Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Dermatol Surg 35:475-81; discussion 481-2. 2009..Recently, variable-pulsed erbium:yttrium aluminum garnet (Er:YAG) lasers have shown favorable results in skin resurfacing, with minimal downtime and adverse effects...
- Topical mitomycin chemotherapy for conjunctival malignant melanoma and primary acquired melanosis with atypia: 12 years' experienceMadhavi Kurli
The New York Eye Cancer Center, The Fifth Floor, 115 East 61st Street, New York, NY 10021, USA
Graefes Arch Clin Exp Ophthalmol 243:1108-14. 2005To report 12-year follow-up experience with topical mitomycin chemotherapy for diffuse and multifocal primary acquired melanosis (PAM) with atypia and conjunctival melanoma.
- Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coliZhong Chuan Wang
Department of Anorectal Surgery and Colorectal Cancer Center, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
J Dig Dis 14:417-24. 2013To determine the hedgehog (Hh) signaling pathway correlated with the development of colon cancer and melanosis coli.
- Neurocutaneous melanosis in association with Dandy-Walker malformation: case report and literature reviewS Schreml
Dermatological Outpatient Facility, Regensburg, Germany
Clin Exp Dermatol 33:611-4. 2008Neurocutaneous melanosis (NCM) is a rare congenital noninheritable phacomatosis characterized by large and/or numerous cutaneous congenital melanocytic naevi (CMN) in combination with melanocytic leptomeningeal tumours...
- Pseudomelanosis of stomach, duodenum, and jejunumLeonard B Weinstock
Washington University Medical Center, St Louis, Missouri, USA
Gastrointest Endosc 58:578. 2003
- Combined ultrapulse CO2 laser and Q-switched alexandrite laser compared with Q-switched alexandrite laser alone for refractory melasma: split-face designSuhattaya Angsuwarangsee
Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Dermatol Surg 29:59-64. 2003..To date, the mainstay of treatment, including various hypopigmenting agents and chemical peels, is ineffective and can cause adverse effects. Laser is a new approach and is yet to be explored for its efficacy and safety...
- Histologic and ultrastructural analysis of melasma after fractional resurfacingDavid J Goldberg
Skin Laser and Surgery Specialists of NY NJ, New York, New York, USA
Lasers Surg Med 40:134-8. 2008..Recently, successful improvement in melasma has been achieved with this laser system. We undertook this study to evaluate the ultrastructural changes associated with fractional laser treatment of melasma...
- The genetic basis of adaptive melanism in pocket miceMichael W Nachman
Department of Ecology and Evolutionary Biology, Biosciences West Building, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 100:5268-73. 2003..Interestingly, another melanic population of these mice on a different lava flow shows no association with Mc1r mutations, indicating that adaptive dark color has evolved independently in this species through changes at different genes...
- The treatment of melasma with topical creams alone, CO2 fractional ablative resurfacing alone, or a combination of the two: a comparative studyMario A Trelles
Instituto Medico Vilafortuny, Antoni de Gimbernat Foundation, Cambrils, Spain
J Drugs Dermatol 9:315-22. 2010..This three-armed study compares topical creams, CO2 ablative fractional resurfacing and the combination of both modalities...
- Spectrum of central nervous system abnormalities in neurocutaneous melanocytosisVijay Ramaswamy
Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Dev Med Child Neurol 54:563-8. 2012..We sought to define the spectrum of central nervous system abnormalities in children with neurocutaneous melanocytosis...
- The treatment of melasma with fractional photothermolysis: a pilot studyCameron K Rokhsar
Department of Dermatology, Albert Einstein College of Medicine, Bronx, NY, USA
Dermatol Surg 31:1645-50. 2005..Melasma is a common pigmentary disorder that remains resistant to available therapies. Facial resurfacing with the pulsed CO2 laser has been reported successful but requires significant downtime, and there is a risk of adverse sequelae...
- Neurocutaneous melanosis in a newborn with giant congenital melanocytic nevusP David
Department of Neuroradiology, Erasmus Hospital ULB, Brussels, Belgium, and Department of Clinical Physiopathology, Radiodiagnostic Section, University of Florence, Florence, Italy
J Neuroradiol 34:272-5. 2007Neurocutaneous melanosis (NCM) is known as a rare phakomatose characterised by large or numerous pigmented congenital nevi associated with leptomeninges melanin-containing deposits...
- Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRASVeronica A Kinsler
Paediatric Dermatology Department, Great Ormond Street Hospital for Children, London, UK
J Invest Dermatol 133:2229-36. 2013..These results suggest that single postzygotic NRAS mutations are responsible for multiple CMN and associated neurological lesions in the majority of cases. ..
- Utilizing fractional resurfacing in the treatment of therapy-resistant melasmaZeina S Tannous
Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Cosmet Laser Ther 7:39-43. 2005..Multiple treatment modalities have been employed for the management of melasma with minimal to no success...
- Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosisH Takayama
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
J Am Acad Dermatol 44:538-40. 2001..pigmented nevi in both skin and leptomeninges of the central nervous system resembling human neurocutaneous melanosis. We immunohistochemically detected HGF/SF receptor, Met, in a congenital nevus of an infant with neurocutaneous ..
- Exclusion of eleven candidate genes for ocular melanosis in Cairn terriersPaige A Winkler
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA
J Negat Results Biomed 12:6. 2013Ocular melanosis of Cairn terrier dogs is an inherited defect characterized by progressive pigmentation of both eyes which can result in glaucoma and blindness...
- Pseudomelanosis ilei associated with ingestion of charcoal: case report and review of literatureJuhyung Kim
Department of Gastroenterology, Korea University Guro Hospital, Seoul, Korea
Dig Endosc 22:56-8. 2010b>Melanosis or pseudomelanosis of the gastrointestinal tract refers to an accumulation of pigment deposits in the gastrointestinal mucosa. Pigmentation can affect the entire gastrointestinal tract...
- Giant congenital melanocytic nevi: the significance of neurocutaneous melanosis in neurologically asymptomatic childrenR D Foster
Division of Plastic and Reconstructive Surgery, Department of Dermatology, University of California, San Francisco, USA
Plast Reconstr Surg 107:933-41. 2001..characterized by central nervous system involvement, termed leptomeningeal melanocytosis or neurocutaneous melanosis. Although symptomatic neurocutaneous melanosis is rare, we previously reported distinct magnetic resonance (MR) ..
- [Neurocutaneous melanosis]M A Martínez-Granero
Servicio de Neurologia Infantil, Hospital Infantil La Paz, Madrid, Espana
Rev Neurol 25:S265-8. 1997Neurocutaneous melanosis is a sporadic neurocutaneous syndrome characterized by the presence of giant or multiple melanocytic nevi and excessive proliferation of melanotic cells in the central nervous system...
- Ocular melanosis in the Cairn Terrier: histopathological description of the condition, and immunohistological and ultrastructural characterization of the characteristic pigment-laden cellsSimon M Petersen-Jones
Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA
Vet Ophthalmol 11:260-8. 2008To describe the microscopic features and lineage of proliferating/infiltrating pigmented cells in ocular melanosis of Cairn Terriers...
- The epidemiology of nevi and signs of skin aging in the adult general population: Results of the KORA-survey 2000Torsten Schafer
Institute of Social Medicine, Medical University of Luebeck, Luebeck, Germany
J Invest Dermatol 126:1490-6. 2006..In contrast, common and atypical nevi and ephelides decreased significantly with age. Signs of skin aging are frequent and increase, in contrast to common and atypical nevi, with age...
- Prevalence and familial risk of ephelides in Han Chinese adolescentsSen Yang
Department of Dermatology, The First Hospital, Institute of Dermatology, Anhui Medical University, Hefei, Anhui, People s Republic of China
Arch Dermatol Res 300:87-90. 2008..61-7.18, P < 0.001). Our study provided the first information on the prevalence of ephelides in Chinese adolescents and suggests that familial factors are important in determining individual susceptibility to ephelides...
- The risk of melanoma and neurocutaneous melanosis associated with congenital melanocytic neviKara N Shah
The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Semin Cutan Med Surg 29:159-64. 2010..the context of multiple satellite melanocytic nevi, are also associated with the development of neurocutaneous melanosis, which may result in neurologic and neurodevelopmental sequelae and is associated with a significant risk of ..
- Ocular melanosis in the Cairn Terrier: clinical description and investigation of mode of inheritanceSimon M Petersen-Jones
Department of Small Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824 1314, USA
Vet Ophthalmol 10:63-9. 2007To describe the clinical features of ocular melanosis in Cairn Terriers.
- Conjunctival melanoma and melanosis: a reappraisal of terminology, classification and stagingBertil Damato
Ocular Oncology Service, Royal Liverpool University Hospital, Liverpool, UK
Clin Experiment Ophthalmol 36:786-95. 2008This paper aims to stimulate debate on the terminology, classification, grading and staging of conjunctival melanosis and melanoma. We audited our results with 76 invasive conjunctival melanomas...
- Amniotic membrane transplantation in the management of conjunctival malignant melanoma and primary acquired melanosis with atypiaD Paridaens
Rotterdam Eye Hospital, Oculoplastic Service, Rotterdam Eye Hospital, The Netherlands
Br J Ophthalmol 85:658-61. 2001..membrane transplantation (AMT) for the management of conjunctival malignant melanoma and primary acquired melanosis (PAM) with atypia...
- Frictional dermal melanosis (lifa disease) over bony prominencesK E Sharquie
Department of Dermatology, College of Medicine, University of Baghdad, Iraq
J Dermatol 28:12-5. 2001..The histopathology of biopsies from 24 patients showed marked dermal melanosis. Amyloid deposits in the papillary dermis were present in one patient...
- Subclinical speckled perifollicular melanosis of the scalpLudivine Petit
Department of Dermatopathology, University Medical Center Sart Tilman and Sauvenière, B 4000 Liege, Belgium
Eur J Dermatol 12:565-8. 2002..It is concluded that the perifollicular subclinical melanotic pattern is a regional characteristic of cephalic skin, perhaps related to the local production of melanocortins, particularly alpha-MSH by the pilosebaceous unit...
- Melanosis of the areola and nippleJennifer A Sceppa
J Am Acad Dermatol 59:S33-4. 2008
- Neurocutaneous melanosis presenting with hydrocephalus. Case report and review of the literatureFrank L Acosta
Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
J Neurosurg 102:96-100. 2005Neurocutaneous melanosis (NCM) is a rare congenital neurocutaneous syndrome characterized by large or multiple congenital melanocytic nevi and benign or malignant melanocytic tumors of the leptomeninges...
- Diffuse melanosis after chemotherapy-induced tumor lysis syndrome in a patient with metastatic melanomaKlaus J Busam
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Cutan Pathol 31:274-80. 2004Diffuse melanosis is a rare event associated with advanced metastatic malignant melanoma...
- The treatment of melasma: a review of clinical trialsAditya K Gupta
Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site and the University of Toronto, Ontario, Canada
J Am Acad Dermatol 55:1048-65. 2006..Chemical peels, laser treatments, and intense pulsed light therapy are additional therapeutic modalities that have been used to treat melasma...
- Melasma: histopathological characteristics in 56 Korean patientsW H Kang
Departments of Dermatology and Pathology, and Laboratory of Cell Biology, Institute for Medical Sciences, Ajou University School of Medicine, 5 Wonchon dong, Paldal Ku, Suwon 442 721, Korea
Br J Dermatol 146:228-37. 2002..Melasma is a common acquired symmetrical hypermelanosis characterized by irregular light to dark brown macules and patches on sun-exposed areas of the skin. Its histopathological characteristics are not fully understood...
- Mutations of an arylalkylamine-N-acetyltransferase, Bm-iAANAT, are responsible for silkworm melanism mutantFang yin Dai
College of Biotechnology, Institute of Sericulture and Systems Biology, Southwest University, Chongqing 400715, China
J Biol Chem 285:19553-60. 2010..To our knowledge, this is the first report showing a role for arylalkylamine-N-acetyltransferases in color pattern mutation in Lepidoptera...
- Recent history of melanism in American peppered mothsB S Grant
Department of Biology, College of William and Mary, Williamsburg, VA 23187 8795, USA
J Hered 93:86-90. 2002..We contrast these changes to the near absence of melanism in a southern state-Virginia-during that same period. As in Britain, the decline in melanism in American peppered moths followed clean air legislation...
- [Neurocutaneous melanosis]S Diaz-Insa
Servicio de Neurologia, Hospital Sant Joan de Deu, Barcelona, Espana
Rev Neurol 26:769-71. 1998Neurocutaneous melanosis is an infrequent condition characterized by the presence of numerous gigantic cutaneous naevi and melanocytic infiltration of the central nervous system and/or the leptomeningeal layers...
- Neurocutaneous melanosisF Di Rocco
Section of Pediatric Neurosurgery, Institute of Neurosurgery, Catholic University Medical School, Largo Gemelli 8, 00168, Rome, Italy
Childs Nerv Syst 20:23-8. 2004Neurocutaneous melanosis (NCM) is a rare phakomatosis characterized by a focal or diffuse proliferation of melanin-producing cells in both the skin and the leptomeninges...
- Neurocutaneous melanosis in association with the Dandy-Walker complexJ N Kadonaga
Department of Dermatology, Oregon Health Sciences University, Portland
Pediatr Dermatol 9:37-43. 1992An infant had a giant congenital nevus, neurocutaneous melanosis (NCM), and a Dandy-Walker malformation of the brain...
- Multiple giant congenital melanocytic nevi with central nervous system melanosisS R Ahuja
Division of Pediatric Neurology, Department of Pediatrics, LTM Medical College and LTMG Hospital, Sion, Mumbai 400022, India
Neurol India 51:541-3. 2003A case of multiple giant congenital melanocytic naevi in whom central nervous system melanosis was detected at 6 weeks of age is described...
- Neurocutaneous melanosis in association with the Dandy-Walker complex, complicated by melanoma: report of a case and literature reviewCarlos Alfredo Mena-Cedillos
Department of Dermatology, Federico Gómez Children s Hospital of México, Mexico City, Mexico
Pediatr Dermatol 19:237-42. 2002Neurocutaneous melanosis is a rare congenital neurocutaneous syndrome in which benign and malignant melanocytic tumors of the leptomeninges with large or numerous congenital melanocytic nevi develop...
- Neurocutaneous melanosis with associated Dandy-Walker complexAdrian Caceres
Neurosurgery Division, Children s Memorial Hospital, 2300 Children s Plaza, P O Box 28, Chicago, IL, USA
Childs Nerv Syst 22:67-72. 2006The authors report the case of a child with neurocutaneous melanosis associated with a Dandy-Walker complex...
- Melanosis of the colon and terminal ileum associated with primary malignant melanoma of the anorectumSeong Soo Hong
Department of Internal Medicine, Dongguk University International Hospital, Goyang, Gyeonggi, Korea
Gastrointest Endosc 63:886-8. 2006
- Melasma: a reviewFrank C Victor
Robert Wood Johnson University Hospital, New Brunswick, New Jersey, USA
J Cutan Med Surg 8:97-102. 2004..To better understand melasma, a review of its etiologic factors, classification, pathogenesis, and treatment was undertaken...
- Cerebral mass due to neurocutaneous melanosis: eight years laterJ V Schaffer
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Pediatr Dermatol 18:369-77. 2001Neurocutaneous melanosis (NCM) is associated most commonly with giant congenital melanocytic nevi (CMN), in particular those on the scalp or in a posterior axial location that are accompanied by satellite congenital nevi...
- MR Imaging of pial melanosis secondary to a posterior fossa melanotic ependymomaSait Albayram
Division of Neuroradiology, Department of Radiology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
AJNR Am J Neuroradiol 26:804-8. 2005..There was no evidence of hemosiderin in tumor cells and in interstitial spaces. Pial melanin accumulation secondary to a posterior fossa melanotic ependymoma explained our MR findings...
- Dermoscopy identifies histopathologically indiscernible malignant lesion of atypical melanosis of the foot, an early lesion of acral lentiginous melanoma in situHsiu Hui Chiu
Department of Dermatology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Dermatol Surg 34:979-83. 2008
- Primary acquired melanosis of the conjunctiva: risks for progression to melanoma in 311 eyes. The 2006 Lorenz E. Zimmerman lectureJerry A Shields
Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Ophthalmology 115:511-519.e2. 2008To evaluate the clinical features and risks for transformation of conjunctival primary acquired melanosis (PAM) into melanoma.
- Melanosis ilei associated with chronic ingestion of edible charcoalTae Hoon Lee
Division of Gastroenterology, Department of Internal Medicine, University of Soonchunhyang College of Medicine, Cheonan Hospital, Cheonan, Korea
Gastrointest Endosc 67:1174; discussion 1175. 2008
- Neurocutaneous melanosisHanspaul S Makkar
Department of Dermatology and Pediatrics, University of California, San Francisco, CA, USA
Semin Cutan Med Surg 23:138-44. 2004Neurocutaneous melanosis (NCM) is a rare congenital disorder characterized by the presence of large or multiple congenital melanocytic nevi in association with benign or malignant proliferation of melanocytes in the leptomeninges...
- Constipation, anthranoid laxatives, melanosis coli, and colon cancer: a risk assessment using aberrant crypt fociRiccardo Nascimbeni
Cattedra di Chirurgia Generale, University of Brescia, 25124 Brescia, Italy
Cancer Epidemiol Biomarkers Prev 11:753-7. 2002The associations between colorectal cancer (CRC) and constipation, anthranoid laxative use, and melanosis coli are controversial...
- Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: review of the evidence and recommendations for treatmentRajeev Chalasani
Ocular Oncology Unit, Save Sight Institute, Sydney Eye Hospital, Sydney, New South Wales, Australia
Clin Experiment Ophthalmol 34:708-14. 2006..excision with cryotherapy is a well-established treatment option for malignant melanoma or primary acquired melanosis (PAM) with atypia of the conjunctiva and cornea...
- A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasmaLiliana Elizabeth Espinal-Perez
Department of Dermatology, Hospital Central, University of San Luis Potosi, Mexico
Int J Dermatol 43:604-7. 2004..Melasma is an acquired treatment-resistant hyperpigmentation of the skin...
- Melanosis of the bladder: a rare endoscopic and histopathological findingF Di Fiore
Department of Urology, Monaldi Hospital, Naples, Italy
Urol Int 78:185-7. 2007b>Melanosis of the bladder represents a rare condition characterized by anomalous deposits of melanin-containing pigment. To our knowledge, so far, just 5 cases have been reported in the literature...
- Primary malignant melanoma of the rectum arising against a background of rectal melanosisAlberto Righi
Centro Consulenze Anatomia Patologica Oncologica, Centro Diagnostico Italiano, Milan, Italy
Int J Surg Pathol 16:335-6. 2008
- [Melanosis of the urinary bladder--a case report with 10 years of follow-up and review of literature]P F Engelhardt
Abteilung für Urologie, Thermenklinikum Baden, Osterreich
Aktuelle Urol 37:222-4. 2006..We report for the first time a case of solitary melanosis of the urinary bladder with a follow-up of more than 10 years.
- Different genes underlie adaptive melanism in different populations of rock pocket miceH E Hoekstra
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Mol Ecol 12:1185-94. 2003..These results indicate that adaptive melanism has arisen at least twice in C. intermedius and that these similar phenotypic changes have a different genetic basis...
- The treatment of primary acquired melanosis (PAM) with atypia by topical Mitomycin CJacob Pe'er
Department of Ophthalmology, Hadassah Hebrew University Medical Center, 91120 Jerusalem, Israel
Am J Ophthalmol 139:229-34. 2005To report our results of 12 consecutive patients with conjunctival primary acquired melanosis (PAM) with atypia who were treated by topical Mitomycin C (MMC).
- Anthranoid self-medication causing rapid development of melanosis coliM Willems
Department of Gastroenterology and Hepatology Ca 415, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
Neth J Med 61:22-4. 2003It is widely known that long-term use of anthranoid-containing laxatives is the cause of melanosis coli...
- Topical interferon alfa in the treatment of conjunctival melanoma and primary acquired melanosis complexPaul T Finger
The New York Eye Cancer Center, New York, New York 10065, USA
Am J Ophthalmol 145:124-129. 2008To report on topical interferon alfa-2b for conjunctival malignant melanoma (CMM) and primary acquired melanosis with atypia (PAM).
- Melanism in peromyscus is caused by independent mutations in agoutiEvan P Kingsley
Department of Organismic and Evolutionary Biology and The Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts, United States of America
PLoS ONE 4:e6435. 2009..These results show that melanism has evolved independently in these populations through mutations in the same gene, and suggest that melanism produced by mutations in genes other than Mc1r may be more common than previously thought...
- Low-risk and high-risk histologic features in conjunctival primary acquired melanosis with atypia: Clinicopathologic analysis of 29 casesMitsuhiro Sugiura
Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
Am J Surg Pathol 31:185-92. 2007..conjunctival proliferations are included in a heterogeneous category designated as primary acquired melanosis (PAM) with atypia. We performed clinicopathologic analysis of 29 cases of PAM with atypia...
- An unusual case of neurocutaneous melanosisDaniela Oliveira de Andrade
Setor de Neurofisiologia Clinica, Hôpital Sarah, Salvador BA, Brazil
Epileptic Disord 6:145-52. 2004The neurocutaneous melanosis (NCM) is a rare, neuroectodermal dysplasia defined by the association of giant or multiple, nonmalignant pigmented cutaneous nevi with leptomeningeal melanosis or melanoma...
- Neurocutaneous melanosis and epilepsy surgeryFrederick Andermann
Epileptic Disord 7:57. 2005
- Secretion of arsenic, cholesterol, vitamin E, and zinc from the site of arsenical melanosis and leucomelanosis in skinA K M Yousuf
Division of Arsenic Research, Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahba, Dhaka, Bangladesh
Clin Toxicol (Phila) 49:374-8. 2011b>Melanosis and leucomelanosis with or without keratosis are the earliest symptoms of arsenicosis...
- Atypical melanosis of the foot showing a dermoscopic feature of the parallel ridge patternIsil Kilinc Karaarslan
Department of Dermatology, Ege University Medical Faculty, Izmir, Turkey
J Dermatol 34:56-9. 2007..There was no sign of regression such as fibrous tissue or host reaction. Atypical melanosis of the foot has rarely been reported in the published work, which are from Japan and Korea...
- Melanosis coli involving pericolonic lymph nodes associated with the herbal laxative Swiss Kriss: a rare and incidental finding in a patient with colonic adenocarcinomaC Alexander Ewing
Department of Pathology, Georgetown University Hospital, Washington, DC 20007, USA
Arch Pathol Lab Med 128:565-7. 2004b>Melanosis coli is a well-known condition in which macrophages filled with a lipofuscin-like pigment are found in the colonic lamina propria...
- Prevalence and awareness of melasma during pregnancyAthar Moin
Department of Dermatology, Faculty of Medicine, Shahed University, Tehran, Iran
Int J Dermatol 45:285-8. 2006..There is little information on its prevalence during pregnancy in Iran. Objective To determine the prevalence and awareness of melasma during pregnancy at the Shahed University Hospitals of Tehran, Iran...
- "Melanosis" in the small and large intestineHugh James Freeman
Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
World J Gastroenterol 14:4296-9. 2008..Pigment may also be detected in the small intestine. Although labeled as melanosis, electron microscopy and X-ray analytical methods have provided evidence that this pigment is not melanin at all,..
- Application of computerized image analysis in pigmentary skin diseasesE S Lee
Department of Dermatology, and Laboratory of Cell Biology, Ajou University School of Medicine and Institute for Medical Sciences, Suwon, Korea
Int J Dermatol 40:45-9. 2001....
- Isolated choroidal melanocytosis: a distinct clinical entity?James J Augsburger
Department of Ophthalmology, Health Professions Building, Suite 350, 3223 Eden Avenue, Cincinnati, OH 45267 0527, USA
Graefes Arch Clin Exp Ophthalmol 244:1522-7. 2006..The objective was to describe a distinct, limited form of congenital ocular melanocytosis that involves the choroid only...
- Clinical, dermoscopy and histological correlation study of melanotic pigmentations in excision scars of melanocytic tumoursR Botella-Estrada
Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain
Br J Dermatol 154:478-84. 2006..Recurrent naevi may sometimes adopt unusual features that make them difficult to differentiate from a melanoma...
- Neurocutaneous melanosis: clinical presentationsChristina M Plikaitis
Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27175 1075, USA
J Craniofac Surg 16:921-5. 2005
- Esophageal melanocytosis morphologic features and review of the literatureFuju Chang
Department of Histopathology, St Thomas Hospital, Guy s and St Thomas NHS Foundation Trust, London, United Kingdom
Arch Pathol Lab Med 130:552-7. 2006..Following a search of the bibliographic databases (PubMed and Medline) regarding esophageal melanocytosis and melanosis, thirty-four cases of isolated esophageal melanocytosis (including one unpublished case from us) were found...
- Melanocytic nevi: challenging clinical situations in pediatric dermatologyAlbert C Yan
Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Adv Dermatol 21:65-80. 2005
- In vivo confocal microscopy of pigmented conjunctival tumorsElisabeth M Messmer
Department of Ophthalmology, Ludwig Maximilians University, Mathildenstrasse 8, 80336 Munich, Germany
Graefes Arch Clin Exp Ophthalmol 244:1437-45. 2006..To analyze the appearance of conjunctival pigmented tumors as seen by in vivo confocal microscopy...
- Neurocutaneous melanosis: an atypical presentationSiddharth Khera
Department of Dermatology and Venereology, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India
J Dermatol 32:602-5. 2005..Clinically and histologically, the diagnosis was suggestive of neurocutaneous melanosis (NCM)...
- Melanotic macule of nail unit and its clinicopathologic spectrumSameera Husain
College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Am Acad Dermatol 54:664-7. 2006..This underscores the importance of obtaining a biopsy of the nail matrix in patients who present with solitary longitudinal melanonychia...
- Predictive value of exfoliative cytology in pigmented conjunctival lesionsSander Keijser
Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands
Acta Ophthalmol Scand 84:188-91. 2006..Exfoliative cytology may be helpful, but reliable data regarding the sensitivity and specificity of this test are currently lacking. We determined the value of exfoliative cytology with regard to pigmented conjunctival lesions...
- SCALP syndrome: sebaceous nevus syndrome, CNS malformations, aplasia cutis congenita, limbal dermoid, and pigmented nevus (giant congenital melanocytic nevus) with neurocutaneous melanosis: a distinct syndromic entityJoseph Lam
Rady Children s Hospital, San Diego, California, USA
J Am Acad Dermatol 58:884-8. 2008....
- Impression cytology of melanocytic conjunctival tumours using the Biopore membraneS Keijser
Department of Ophthalmology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands
Eur J Ophthalmol 17:501-6. 2007..To compare a new Biopore membrane impression cytology method with the routinely used exfoliative cytology in patients with a melanocytic lesion of the conjunctiva...
- Giant congenital melanocytic neviJugpal S Arneja
Section of Plastic Surgery, Children s Hospital of Michigan and Wayne State University, Detroit, MI, USA
Plast Reconstr Surg 120:26e-40e. 2007..2. Know the natural history and potential complications associated with a giant congenital melanocytic nevus. 3. Outline the nonsurgical and surgical options available to treat a giant congenital melanocytic nevus...
- Three unusual neuropathologic-related causes of sudden deathDennis J Chute
Dutchess County Medical Examiner s Office, 387 Main Street, Poughkeepsie, NY 12601, USA
J Forensic Sci 53:734-8. 2008..man who died of a seizure due to malignant melanoma of the temporal lobe associated with neurocutaneous melanosis (NCM)...
- Neurocutaneous melanosis associated with autoimmune diabetes mellitusKevin R Joseph
Child Neurology Section, Madigan Army Medical Center, Tacoma, WA, USA
Neurology 68:1862-3. 2007
- Large primary meningeal melanoma in an adult patient with neurocutaneous melanosisFelix Kiecker
Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
Clin Neurol Neurosurg 109:448-51. 2007Neurocutaneous melanosis is often associated with melanoma of the central nervous system. Due to the inconspicuously looking cutaneous melanosis additional examinations are often not performed...
- [Neurocutaneous melanosis--case report]Justyna Paprocka
Kliniki Pediatrii i Neurologii Wieku Rozwojowego Katedry Pediatrii, Slaskiej Akademii Medycznej w Katowicach
Wiad Lek 57:520-3. 2004..Magnetic resonance imaging (MRI) of the head performed at the age of 2 months showed melanin deposits in the temporal lobes. The diagnosis of neurocutaneous melanosis was made on the basis of clinical picture.
- Sudden change of a large congenital melanocytic nevus to neurocutaneous melanosisChoong Jae Lee
Department of Plastic and Reconstructive Surgery, College of Medicine, Inha University, Incheon, South Korea
J Craniofac Surg 17:1216-8. 2006Neurocutaneous melanosis (NCM) is a congenital phakomatosis in which large congenital melanocytic nevi are associated with a benign or malignant melanocytic tumor of the leptomeninges...
- [Pigmented vulvar lesions]C Renaud-Vilmer
Spécialiste des centres anticancéreux, Centre Rene Huguenin, 25, rue Dailly, 92210 Saint Cloud, France
Ann Dermatol Venereol 133:717-23. 2006
- Appearance of melanocytic nevi on the backs of young Australian children: a 7-year longitudinal studyElizabeth Milne
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, West Perth, Australia
Melanoma Res 18:22-8. 2008..Longitudinal studies have important advantages over cross-sectional studies in the description of nevus development with age, and should be the preferred study design...
- Tumoral melanosis as a manifestation of a completely regressed primary melanoma with metastasesS H Ng
Br J Dermatol 155:627-8. 2006
- Acute kidney injury in a patient with melanuria, diffuse melanosis, and metastatic malignant melanomaThilo Gambichler
Department of Dermatology, Ruhr University Bochum, Bochum, Germany
Am J Clin Dermatol 9:267-70. 2008Diffuse melanosis with melanuria is a rare complication of metastatic malignant melanoma that is associated with a very poor prognosis. Acute kidney injury secondary to melanuria has not been reported previously...
- Repeated treatment protocols for melasma and acquired dermal melanocytosisKotaro Yoshimura
Department of Plastic Surgery, University of Tokyo, School of Medicine, Tokyo, Japan
Dermatol Surg 32:365-71. 2006..Melasma and acquired dermal melanocytosis (ADM; acquired bilateral nevus of Ota-like macules) are both seen most commonly symmetrically on the face of women with darker skin and are also known as difficult conditions to treat...
- Microbiome-Based Risk Assessment: Reciprocal Effects of Arsenic on EnvironmentalStephanie Bachas-Daunert; Fiscal Year: 2013..Chronic exposure leads to arsenicosis, which includes melanosis, keratosis, as well as lung, bladder, kidney, and skin cancer...
- Selenium against arsenic toxicity and skin lesionsJULIAN SPALLHOLZ; Fiscal Year: 2005..Background: Arsenicosis in children and adults is characterized by 1) melanosis on hands and trunk, 2) palmar-plantar hyperkeratosis, 3) basal and squamous cell carcinomas, and 4) various ..
- Gene Therapy of Autosomal Recessive RPSimon Petersen Jones; Fiscal Year: 2006..abstract_text> ..
- Molecular Biology of RetinoblastomaDaniel Albert; Fiscal Year: 2006..Lastly the potency of the 19-nor compounds wil be compared to standard chemotherapy and their possible synergistic effect in multi-drug treatment established. ..
- Chemo-prevention of UVB-induced Basal Cell Carcinomas+/*Mohammad Athar; Fiscal Year: 2004....
- OCULAR MELANOMAPaul Finger; Fiscal Year: 2003..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
- Role of p53 and ptc tumor suppressive pathways in BCCs development and preventionMohammad Athar; Fiscal Year: 2010....
- THE ROLE OF RB IN THE RETINA & OTHER TISSUESJAMES HARBOUR; Fiscal Year: 2009..Consequently, these aims are highly relevant to the vision statement of the NEI, and they address several major program goals and objectives of the Retinal Diseases Program. ..
- CORE GRANT FOR VISION RESEARCHHerbert Kaufman; Fiscal Year: 2008..This Core Grant has [unreadable] been a vital force in keeping vision research highly active at LSU for the past 25 years, and we hope that it will continue to serve this function in the future. [unreadable] [unreadable]..
- Efficacy of Web-based Training in Skin Cancer TriageMartin Weinstock; Fiscal Year: 2007..If this course is found to be efficacious, it will be made freely available on the web, and we will plan efforts to encourage its broad dissemination. [unreadable] [unreadable]..
- SKIN SELF EXAMINATION FOR EARLY DETECTION OF MELANOMAMartin Weinstock; Fiscal Year: 2002..The knowledge and experiment thus gained will aid the continuing efforts to encourage SSE and reduce melanoma mortality. ..
- Effect of vertebral endplate composition on disc healthFrank Acosta; Fiscal Year: 2006..unreadable] [unreadable]..
- METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGEHenry Mankin; Fiscal Year: 2001..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..