hyperpigmentation

Summary

Summary: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.

Top Publications

  1. ncbi Side effects and complications of laser therapy
    Elizabeth I McBurney
    Department of Dermatology, Louisiana State University Health Sciences Center, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Dermatol Clin 20:165-76. 2002
  2. ncbi Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene
    H Maeyama
    Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan
    Gastroenterology 120:210-5. 2001
  3. ncbi Laugier and Hunziker pigmentation: a lentiginous proliferation of melanocytes
    Roger T Moore
    Department of Dermatology, Rush Medical College, Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, 507 Kidston, Chicago, IL 60612, USA
    J Am Acad Dermatol 50:S70-4. 2004
  4. ncbi Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial
    A B Kimball
    Harvard Medical School, Boston, MA 02114, USA
    Br J Dermatol 162:435-41. 2010
  5. ncbi Central role of p53 in the suntan response and pathologic hyperpigmentation
    Rutao Cui
    Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 128:853-64. 2007
  6. ncbi Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo
    D Kovacs
    San Gallicano Dermatologic Institute, IRCCS, Via Elio Chianesi 53, Rome 00144, Italy
    Br J Dermatol 163:1020-7. 2010
  7. ncbi Postinflammatory hyperpigmentation: etiologic and therapeutic considerations
    Valerie D Callender
    Callender Skin and Laser Center, 12220 Annapolis Blvd, Glenn Dale, MD 20769, USA
    Am J Clin Dermatol 12:87-99. 2011
  8. ncbi The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis
    S Kadono
    Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan
    J Invest Dermatol 116:571-7. 2001
  9. pmc Palate hyperpigmentation caused by prolonged use of the anti-malarial chloroquine
    Mário Rodrigues de Melo Filho
    Department of Dentistry, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil
    Head Neck Pathol 6:48-50. 2012
  10. ncbi Postinflammatory hyperpigmentation
    Susan Taylor
    Department of Dermatology, Columbia University, and the Skin of Color Center, St Luke s Roosevelt Hospital Center, New York, NY, USA
    J Cutan Med Surg 13:183-91. 2009

Detail Information

Publications241 found, 100 shown here

  1. ncbi Side effects and complications of laser therapy
    Elizabeth I McBurney
    Department of Dermatology, Louisiana State University Health Sciences Center, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Dermatol Clin 20:165-76. 2002
    ..An informed patient is an important factor in the healing process and contributes to the success of the procedure...
  2. ncbi Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene
    H Maeyama
    Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan
    Gastroenterology 120:210-5. 2001
    We describe 2 siblings with multiple gastrointestinal stromal tumors (GISTs) and cutaneous hyperpigmentation. Both had a point mutation of the c-kit gene...
  3. ncbi Laugier and Hunziker pigmentation: a lentiginous proliferation of melanocytes
    Roger T Moore
    Department of Dermatology, Rush Medical College, Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, 507 Kidston, Chicago, IL 60612, USA
    J Am Acad Dermatol 50:S70-4. 2004
    ..Further studies are warranted to determine if this pigmentation disorder represents a spectrum of histopathologic change or, in fact, should be renamed mucocutaneous lentiginosis of Laugier and Hunziker...
  4. ncbi Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial
    A B Kimball
    Harvard Medical School, Boston, MA 02114, USA
    Br J Dermatol 162:435-41. 2010
    ..In small clinical studies, niacinamide-containing and NAG-containing formulations reduced the appearance of hyperpigmentation.
  5. ncbi Central role of p53 in the suntan response and pathologic hyperpigmentation
    Rutao Cui
    Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 128:853-64. 2007
    ..p53 thus functions as a sensor/effector for UV pigmentation, which is a nearly constant environmental exposure. Moreover, this pathway is activated in numerous conditions of pathologic pigmentation and thus mimics the tanning response...
  6. ncbi Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigo
    D Kovacs
    San Gallicano Dermatologic Institute, IRCCS, Via Elio Chianesi 53, Rome 00144, Italy
    Br J Dermatol 163:1020-7. 2010
    ..Despite the association of SL to ultraviolet (UV) exposure, the mechanisms underlying the development of these spots are not completely defined...
  7. ncbi Postinflammatory hyperpigmentation: etiologic and therapeutic considerations
    Valerie D Callender
    Callender Skin and Laser Center, 12220 Annapolis Blvd, Glenn Dale, MD 20769, USA
    Am J Clin Dermatol 12:87-99. 2011
    Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions. PIH can have a negative impact on a patient's quality of life, particularly for darker-skinned patients...
  8. ncbi The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis
    S Kadono
    Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan
    J Invest Dermatol 116:571-7. 2001
    Little is known about the mechanism(s) underlying hyperpigmentation in lentigo senilis...
  9. pmc Palate hyperpigmentation caused by prolonged use of the anti-malarial chloroquine
    Mário Rodrigues de Melo Filho
    Department of Dentistry, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil
    Head Neck Pathol 6:48-50. 2012
    ..Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist...
  10. ncbi Postinflammatory hyperpigmentation
    Susan Taylor
    Department of Dermatology, Columbia University, and the Skin of Color Center, St Luke s Roosevelt Hospital Center, New York, NY, USA
    J Cutan Med Surg 13:183-91. 2009
    Postinflammatory hyperpigmentation (PIH) commonly occurs in Fitzpatrick skin types III to VI and can have a considerable impact on quality of life...
  11. ncbi Optimal management of recalcitrant disorders of hyperpigmentation in dark-skinned patients
    Alexander J Stratigos
    Department of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital for Skin and Venereal Diseases, Athens, Greece
    Am J Clin Dermatol 5:161-8. 2004
    ..Hyperpigmented disorders such as melanosis (melasma), post-inflammatory hyperpigmentation, drug-induced hyperpigmentation, and erythema dyschromicum perstans tend to have a prolonged course and, in ..
  12. ncbi Case for diagnosis
    Ana Carolina Figueiredo Pereira Cherobin
    Department of Dermatology, Hospital das Clinicas, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    An Bras Dermatol 87:151-2. 2012
    ..Its etiology is unknown and there is no specific treatment for the condition. We report a case of ashy dermatosis in a 41-year-old patient with extensive lesions on the trunk and limbs...
  13. ncbi Postinflammatory hyperpigmentation secondary to external insult: an overview of the quantitative analysis of pigmentation
    Sonia A Lamel
    Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Cutan Ocul Toxicol 32:67-71. 2013
    Despite new technologies, few studies have quantified changes in melanocyte numbers associated with postinflammatory hyperpigmentation (PIH) secondary to exogenous causes.
  14. ncbi Addison's disease in Africa--a teaching hospital experience
    S Soule
    Department of Medicine, University of Cape Town, Cape Town, South Africa
    Clin Endocrinol (Oxf) 50:115-20. 1999
    ....
  15. ncbi Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantaris
    Alexander Abess
    Department of Dermatology, Naval Medical Center San Diego, San Diego, CA, USA
    Arch Dermatol 139:337-9. 2003
    Flagellate hyperpigmentation is a well-documented complication of systemic bleomycin sulfate therapy when using doses of 100 U or more as an antineoplastic agent...
  16. ncbi The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1
    L Manaka
    Department of Dermatology, Tokyo Women's Medical University, Japan
    Br J Dermatol 145:895-903. 2001
    ..a strong keratinocyte-derived mitogen and melanogen for human melanocytes, is intrinsically involved in the hyperpigmentation mechanism of SK...
  17. ncbi Management of hyperpigmentation in darker racial ethnic groups
    Pearl E Grimes
    Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA
    Semin Cutan Med Surg 28:77-85. 2009
    Dyschromias, in particular hyperpigmentation, are major issues of concern for people of color...
  18. ncbi Mixed hyperpigmentation and hypopigmentation of iris and choroid in Chediak-Higashi syndrome
    Min Chieh Ho
    Department of Ophthalmology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan
    J AAPOS 17:558-60. 2013
    An 8-year-old Taiwanese girl presented with hyperpigmentation and scattered hypopigmentation in her irides and choroids. Her skin showed hyperpigmentation with speckled hypopigmentation over cheeks and sun-exposed areas...
  19. ncbi Hyperpigmentation: an overview of the common afflictions
    Kimberly A Cayce
    Eastern North Carolina University, Greenville, NC, USA
    Dermatol Nurs 16:401-6, 413-6; quiz 417. 2004
    b>Hyperpigmentation disorders of the skin are common. Three of the more common forms include melasma, lentigines, and post-inflammatory hyperpigmentation. Significant negative psychological consequences can result...
  20. ncbi Photodistribution of blue-gray hyperpigmentation after amiodarone treatment: molecular characterization of amiodarone in the skin
    Alfred Ammoury
    Service de Dermatologie, Centre Hospitalier Universitaire de Toulouse, Hopital Purpan, 31059 Toulouse Cedex, France
    Arch Dermatol 144:92-6. 2008
    For decades, the photodistributed blue-gray skin hyperpigmentation observed after amiodarone therapy was presumably attributed to dermal lipofuscinosis...
  21. ncbi Combined therapy using Q-switched ruby laser and bleaching treatment with tretinoin and hydroquinone for periorbital skin hyperpigmentation in Asians
    Akira Momosawa
    Department of Plastic, Reconstructive, and Aesthetic Surgery, Kyorin University School of Medicine, Tokyo, Japan
    Plast Reconstr Surg 121:282-8. 2008
    Periorbital skin hyperpigmentation, so-called dark circles, is of major concern for many people...
  22. ncbi Hypomelanosis of ito-whorled hyperpigmentation combination: a mirror image presentation
    Rajoo Thapa
    Department of Pediatrics and Pediatric Dermatology Unit, The Institute of Child Health, Kolkata, West Bengal, India
    Pediatr Dermatol 24:572-3. 2007
    ....
  23. ncbi Chemical and instrumental approaches to treat hyperpigmentation
    Stefania Briganti
    San Gallicano Dermatological Institute, Via Elio Chianesi, Rome, Italy
    Pigment Cell Res 16:101-10. 2003
    Many modalities of treatment for acquired skin hyperpigmentation are available including chemical agents or physical therapies, but none are completely satisfactory...
  24. ncbi Two Japanese cases of lichen planus pigmentosus-inversus
    Aki Kashima
    Department of Dermatology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Int J Dermatol 46:740-2. 2007
    ..2B). Both the epidermis and the upper dermis contained CD1a(+) cells (Fig. 2C). The keratinocytes focally and weakly expressed HLA-DR (Fig. 2D). These findings were identical in samples from both patients...
  25. ncbi A new type of minocycline-induced cutaneous hyperpigmentation
    R W Mouton
    Department of Dermatology, Faculty of Health Sciences, University of Stellenbosch and Tygerberg Hospital, PO Box 19063, Tygerberg 7505, South Africa
    Clin Exp Dermatol 29:8-14. 2004
    ..Iron was absent. This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to ..
  26. ncbi Effective and safe use of lasers, light sources, and radiofrequency devices in the clinical management of Asian patients with selected dermatoses
    Henry H L Chan
    University of Hong Kong, Hong Kong
    Lasers Surg Med 37:179-85. 2005
    ..The use of lasers, light sources, and radiofrequency devices in Asian patients differs from their use in Caucasians in several respects...
  27. ncbi Lichen planus pigmentosus-inversus
    L Pock
    Department of Dermatology and Venerology, Charles University 2nd Medical School, Motol University Hospital, Prague, Czech Republic
    J Eur Acad Dermatol Venereol 15:452-4. 2001
    ..Because of the highly characteristic inverse location of the lesions in our patients we propose the designation LPP-inversus for this variant of the disease...
  28. ncbi Squamous papilloma with hyperpigmentation in the skin graft of the neovagina in Rokitansky syndrome: literature review of benign and malignant lesions of the neovagina
    Muhammad T Idrees
    Department of Pathology, Mount Sinai Medical Center, New York, New York, USA
    J Pediatr Adolesc Gynecol 22:e148-55. 2009
    ..It is rare for a benign or malignant neoplasm to develop in a neovagina...
  29. pmc Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways
    Li Chen Wu
    Department of Applied Chemistry, National Chi Nan University, Puli, Nantou, 545, Taiwan
    J Biomed Sci 18:74. 2011
    ..is one of the essential defense mechanisms against oxidative stress or UV irradiation; however, abnormal hyperpigmentation in human skin may pose a serious aesthetic problem...
  30. ncbi Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentation
    Elizabeth T T Makino
    SkinMedica, an Allergan Company, Carlsbad, CA, USA
    J Drugs Dermatol 12:s16-20. 2013
    ..remains the only prescription product available in the United States for the treatment of generalized facial hyperpigmentation. Irritation and the risk of exogenous ochronosis are the main adverse effects for concern...
  31. pmc Inflammation drives wound hyperpigmentation in zebrafish by recruiting pigment cells to sites of tissue damage
    Mathieu Lévesque
    School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK
    Dis Model Mech 6:508-15. 2013
    ..Tissue damage and repair also frequently lead to alterations in skin pigmentation, in particular to wound hyperpigmentation. In this study, we describe a model of wound hyperpigmentation in the translucent zebrafish larva, where we ..
  32. ncbi 4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation
    L Kolbe
    Research and Development, Beiersdorf AG, Hamburg, Germany
    J Eur Acad Dermatol Venereol 27:19-23. 2013
    ..The most prominent target for inhibitors of hyperpigmentation is tyrosinase, the key regulator of melanin production...
  33. ncbi Lichen planus pigmentosus-inversus: case report and review of an unusual entity
    Erich Gaertner
    SaraPath Diagnostics, Sarasota, Florida, USA
    Dermatol Online J 18:11. 2012
    ..The case well highlights this unusual condition and represents the first case reported in the United States...
  34. ncbi [Capecitabine-induced hyperpigmentation]
    C Vázquez-Bayo
    Servicio de Dermatologia, Hospital Universitario Reina Sofia, Cordoba, Espana
    Actas Dermosifiliogr 98:491-3. 2007
    ..adverse effects have been recognized, among which we find the muco-cutaneous ones and, specifically, hyperpigmentation. We report a case of localized cutaneous hyperpigmentation secondary to capecitabine in a woman that ..
  35. ncbi Reversible cutaneous hyperpigmentation and nails with white hair due to vitamin B12 deficiency
    Shiro Niiyama
    Department of Dermatology, Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan
    Eur J Dermatol 17:551-2. 2007
  36. ncbi Hypopigmented macular amyloidosis with or without hyperpigmentation
    M S L Ho
    Department of Dermatology, National Skin Centre, Singapore
    Clin Exp Dermatol 34:e547-51. 2009
    ..of PCA, which shared common features of hypopigmentation as a predominant feature with or without reticular hyperpigmentation, no itching, adult onset and dermal papillary amyloid deposition...
  37. ncbi Images in clinical medicine. Minocycline-induced hyperpigmentation
    Adrian N Holm
    Mayo Clinic, Rochester, MN, USA
    N Engl J Med 355:e23. 2006
  38. ncbi Hyperpigmentation: a review of common treatment options
    Kimberly A Cayce
    Center for Dermatology Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Drugs Dermatol 3:668-73. 2004
    b>Hyperpigmentation disorders are common and include a multitude of forms. They are typically divided into three large categories: dermal, epidermal, or mixed, depending on the site of abnormality...
  39. ncbi Antineoplastic agent-associated serpentine supravenous hyperpigmentation: superficial venous system hyperpigmentation following intravenous chemotherapy
    Elizabeth R C Geddes
    University of Texas Houston Medical School, Department of Dermatology, Houston, TX, USA
    South Med J 103:231-5. 2010
    To review the clinical characteristics and associated antineoplastic agents in patients who developed hyperpigmentation of the superficial venous system after chemotherapy.
  40. ncbi The mechanism of action and clinical benefits of soy for the treatment of hyperpigmentation
    James Leyden
    The University of Pennsylvania, Philadelphia, PA, USA
    Int J Dermatol 50:470-7. 2011
    b>Hyperpigmentation disorders are common and diverse conditions that may require treatment for medical and/or cosmetic reasons...
  41. ncbi Hand-foot hyperpigmentation skin lesions associated with combination gemcitabine-carboplatin (GemCarbo) therapy
    Roman L Kleynberg
    Department of Hematology Oncology, The University of Toledo College of Medicine, OH 43614, USA
    Am J Ther 18:e261-3. 2011
    ..We report an unusual case of hand-foot hyperpigmentation after the use of GemCarbo therapy on a man with stage IV non-small cell lung carcinoma...
  42. ncbi Natural options for the management of hyperpigmentation
    J J Leyden
    University of Pennsylvania, Philadelphia, PA, USA
    J Eur Acad Dermatol Venereol 25:1140-5. 2011
    ....
  43. ncbi Hydroxychloroquine-induced hyperpigmentation: the staining pattern
    Puja K Puri
    Department of Dermatology Dermatopathology, Geisinger Medical Center, Danville, PA 17822, USA
    J Cutan Pathol 35:1134-7. 2008
    We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female (case 1) and a 78-year-old female (case 2), both receiving 400 mg per day...
  44. ncbi Prospective study on the treatment of postburn hyperpigmentation by intense pulsed light
    Wai Sun Ho
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Lasers Surg Med 32:42-5. 2003
    Postburn hyperpigmentation is a common phenomenon among Asian especially over grafted areas and sometimes over donor sites and healed wounds without skin graft...
  45. ncbi Café-au-lait spots in neurofibromatosis type 1 and in healthy control individuals: hyperpigmentation of a different kind?
    Sofie De Schepper
    Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
    Arch Dermatol Res 297:439-49. 2006
    ..We conclude that SCF is an important cytokine in NF1 skin, but that additional (growth) factors and/or genetic mechanisms are needed to induce NF1-specific CALM hyperpigmentation.
  46. ncbi Capecitabine-induced hand-foot syndrome and cutaneous hyperpigmentation in an elderly vitiligo patient
    R Tavares-Bello
    J Eur Acad Dermatol Venereol 21:1434-5. 2007
  47. ncbi Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study
    Pearl Grimes
    Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
    Cutis 77:45-50. 2006
    ..The present investigation assessed tazarotene 0.1% cream for the treatment of postinflammatory hyperpigmentation (PIH) in a double-blind, randomized, vehicle-controlled study of 74 patients from darker racial ethnic ..
  48. ncbi Managing common dermatoses in skin of color
    Marcelyn K Coley
    Skin of Color Center, Department of Dermatology, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Semin Cutan Med Surg 28:63-70. 2009
    ..part as a result of the sequelae often associated with the conditions in their own right - postinflammatory hyperpigmentation and scarring - and potential iatrogenic adverse effects that may occur during treatment...
  49. ncbi Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentation
    D Hexsel
    School of Medicine, University of Passo Fundo, Rio Grande do Sol, Brazil
    Br J Dermatol 156:7-12. 2006
    ..of skin phototypes and pigmentation and are prone to an increased incidence of melasma and post-inflammatory hyperpigmentation. Little research has been conducted to evaluate the frequency, course, effects, tolerability and treatment ..
  50. ncbi A retrospective study on the efficacy and complications of Q-switched alexandrite laser in the treatment of acquired bilateral nevus of Ota-like macules
    A Y Lam
    Division of Dermatology, Department of Medicine, University of Hong Kong
    Dermatol Surg 27:937-41; discussion 941-2. 2001
    ..of Ota-like macules (ABNOM), or Hori's macules, is a common Asian condition that is characterized by bluish hyperpigmentation in the bilateral malar regions...
  51. ncbi A kindred with familial progressive hyperpigmentation-like disorder: implication of fibroblast-derived growth factors in pigmentation
    Giorgia Cardinali
    San Gallicano Dermatological Institute, IRCCS, Via Elio Chianesi 53, 00144 Rome, Italy
    Eur J Dermatol 19:469-73. 2009
    ..The patients (father and daughter) had had a widespread hyperpigmentation since early life which then progressively worsened with the appearance of hyperpigmented macules, café-au-..
  52. ncbi Melanoma hyperpigmentation is strongly associated with KIT alterations
    Julie M Wu
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Dermatopathol 31:619-25. 2009
    ..sun damage, tumor infiltrating lymphocytes, melanoma in situ, vertical growth phase (VGP), location, and hyperpigmentation. Twenty-eight cases demonstrated 3+ membranous staining...
  53. ncbi Laugier-Hunziker-Baran syndrome
    Kaori Yago
    Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:e20-5. 2008
    ..The differential diagnosis of oral and pigmented lesions between Laugier-Hunziker-Baran syndrome and other disorders, Peutz-Jeghers syndrome in particular, requires our utmost consideration...
  54. ncbi Laugier-Hunziker syndrome associated with actinic lichen planus
    S Aytekin
    J Eur Acad Dermatol Venereol 18:221-3. 2004
  55. pmc Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation
    Zhi Qiang Wang
    State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    Am J Hum Genet 84:672-7. 2009
    Familial progressive hyperpigmentation (FPH) is an autosomal-dominantly inherited disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age...
  56. ncbi Progressive hyperpigmentation and generalized lentiginosis without associated systemic symptoms: a rare hereditary pigmentation disorder in south-east Germany
    Livia Zanardo
    Department of Dermatology, University of Regensburg, Germany
    Acta Derm Venereol 84:57-60. 2004
    Familial progressive hyperpigmentation is rarely described in the literature. We report on five patients from three different families presenting with a peculiar progressive pigmentary disorder...
  57. ncbi Quantitative evaluation of skin condition in an epidemiological survey of females living in northern versus southern Japan
    G G Hillebrand
    Procter and Gamble, One Procter and Gamble Plaza, Cincinnati, OH 45202 3315, USA
    J Dermatol Sci 27:S42-52. 2001
    ..high resolution digital imaging followed by computer analysis of facial images for facial skin wrinkling and hyperpigmentation; silicone skin replicas followed by Moiré interferometry for facial skin surface roughness (texture); the ..
  58. ncbi Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study
    Vijay Kumar Garg
    Department of Dermatology, Venereology and Leprology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India
    Dermatol Surg 35:59-65. 2009
    Many clinicians have used glycolic acid (GA) peels for facial acne, scarring, and hyperpigmentation, mainly in lighter skin types...
  59. ncbi Addison's disease
    Lynnette K Nieman
    Reproductive and Biology Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Dermatol 24:276-80. 2006
    ..The cutaneous manifestations include darkening of the skin especially in sun-exposed areas and hyperpigmentation of the palmar creases, frictional surfaces, vermilion border, recent scars, genital skin, and oral mucosa...
  60. ncbi Treatment of Laugier-Hunziker syndrome with the Q-switched alexandrite laser in 22 Chinese patients
    Ya Gang Zuo
    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Arch Dermatol Res 302:125-30. 2010
    ..Our study has also demonstrated QSAL to be highly effective and safe in the treatment of LHS...
  61. ncbi Laugier-Hunziker syndrome: a rare cause of mucocutaneous pigmentation
    T Sabesan
    Department of Oral and Maxillofacial Surgery, Poole General Hospital, Longfleet Road, Poole, Dorset BH15 2JB, UK
    Br J Oral Maxillofac Surg 44:320-1. 2006
    ..An 80-year-old white woman presented with brown pigmentation on both sides of the buccal mucosa and lower lip and patchy freckling in her nails, which was diagnosed as Laugier-Hunziker syndrome...
  62. pmc Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndrome
    A K Lampe
    J Med Genet 40:e77. 2003
  63. ncbi Idiopathic lenticular mucocutaneous pigmentation (Laugier-Hunziker syndrome): a report of a case
    Maria Siponen
    Univeristy of Oulu, Oulu University Hospital, Oulu, Finland
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:288-92. 2003
    Laugier-Hunziker syndrome (LHS) is an acquired, benign, macular hyperpigmentation of the lips and oral mucosa, often associated with pigmentation of the nails...
  64. ncbi Melanin pigmentary disorders: treatment update
    Jean Paul Ortonne
    Service de Dermatologie, Hôpital L Archet 2, Nice, France
    Dermatol Clin 23:209-26. 2005
    ..The treatment of hypomelanotic disorders is still often disappointing, but new therapeutic options provide encouraging results...
  65. ncbi Novel c-KIT germline mutation in a family with gastrointestinal stromal tumors and cutaneous hyperpigmentation
    Miguel Carballo
    Laboratori de Biologia i Genetica Molecular, Servei de Laboratori, Hospital de Terrassa, Terrassa, Spain
    Am J Med Genet A 132:361-4. 2005
    ..We report a familial case of GIST with cutaneous hyperpigmentation associated with a novel germline mutation in the c-KIT gene...
  66. ncbi Improved contrast of peripapillary hyperpigmentation using polarization analysis
    Mariane B Mellem-Kairala
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 46:1099-106. 2005
    To improve detection and quantification of peripapillary hyperpigmentation, associated with aging, open-angle glaucoma, and age-related macular degeneration.
  67. ncbi Iris hyperpigmentation in a Chinese family with ocular albinism and the GPR143 mutation
    Xueshan Xiao
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Am J Med Genet A 149:1786-8. 2009
    ..Here, we report on a Chinese family with OA1 and partial deletion of GPR143. An unusual phenotype of iris hyperpigmentation without translucency was observed in the male patient and the carrier mother...
  68. ncbi Prayer marks
    Abdullah A Abanmi
    Dermatology Department, Research Center, Riyadh Al Kharj Armed Forces Hospital, PO Box 7897, Riyadh 11159, Saudi Arabia
    Int J Dermatol 41:411-4. 2002
    ..marks (PMs) are asymptomatic, chronic skin changes that consist mainly of thickening, lichenification, and hyperpigmentation, and develop over a long period of time as a consequence of repeated, extended pressure on bony prominences ..
  69. ncbi Minocycline-induced hyperpigmentation in rheumatoid arthritis
    Brian T Fay
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 2055, USA
    J Clin Rheumatol 14:17-20. 2008
    Minocycline is recognized as an effective, well-tolerated therapy in rheumatoid arthritis (RA), although its use has been associated with the development of cutaneous hyperpigmentation.
  70. ncbi Application of a combined sulphorhodamine B and melanin assay to the evaluation of Chinese medicines and their constituent compounds for hyperpigmentation treatment
    Rosanna Y Y Lam
    School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Ethnopharmacol 132:274-9. 2010
    To investigate the efficacy of traditional Chinese medicine (TCM) in the treatment of hyperpigmentation problems, extracts of herbs selected based on traditional Chinese medical literature were screened.
  71. ncbi Common hyperpigmentation disorders in adults: Part II. Melanoma, seborrheic keratoses, acanthosis nigricans, melasma, diabetic dermopathy, tinea versicolor, and postinflammatory hyperpigmentation
    Daniel L Stulberg
    Utah Valley Family Practice Residency Program, Provo, Utah, USA
    Am Fam Physician 68:1963-8. 2003
    ..Melasma is a facial hyperpigmentation resulting from the stimulation of melanocytes by endogenous or exogenous estrogen...
  72. ncbi Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygen
    Akemi Ryu
    Research Laboratories, KOSE Corporation, Azusawa, Itabashi ku, Tokyo, Japan
    Biol Pharm Bull 32:1504-9. 2009
    ..Furthermore, we found that topical application of squalene peroxide induced skin hyperpigmentation through increasing prostaglandin E(2) release from keratinocytes in guinea pigs...
  73. ncbi Hyperpigmentation and melasma
    D Rigopoulos
    Department of Dermatology, A Sygros Hospital, University of Athens, Athens, Greece
    J Cosmet Dermatol 6:195-202. 2007
    ..common cause of facial pigmentation, there are many other forms including drug-induced and postinflammatory hyperpigmentation. We review pathogenesis, clinical and histopathological data, effect on quality of life, and treatment ..
  74. ncbi Percutaneous collagen induction: minimally invasive skin rejuvenation without risk of hyperpigmentation-fact or fiction?
    Mathias C Aust
    Klinik für Plastische, Hand und Wiederherstellungschirurgie, Medizinische Hochschule Hannover, Hannover, Germany
    Plast Reconstr Surg 122:1553-63. 2008
    ..It was recently shown in clinical trials that percutaneous collagen induction therapy is an alternative for safely treating wrinkles and scars and for smoothening the skin without the risk of dyspigmentation...
  75. ncbi The prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asians
    Henry H L Chan
    Division of Dermatology, Department of Medicine, University of Hong Kong, Hong Kong SAR, China
    Lasers Surg Med 39:381-5. 2007
    ..However, in Asians, post-inflammatory hyperpigmentation (PIH) is a common adverse effect of laser resurfacing...
  76. ncbi Persistent cutaneous hyperpigmentation after tyrosine kinase inhibition with imatinib for GIST
    Doru T Alexandrescu
    Georgetown Dermatology, Washington, DC, USA
    Dermatol Online J 14:7. 2008
    ..b>Hyperpigmentation of the skin is a less frequent side effect...
  77. ncbi Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopy
    Maria A Pizzichetta
    Division of Medical Oncology C Preventive Oncology, National Cancer Institute, Aviano, Italy
    Arch Dermatol 142:479-83. 2006
    Melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") can be considered as a melanoma-simulating type of acquired melanocytic nevus...
  78. ncbi Topical treatments for melasma and postinflammatory hyperpigmentation
    C B Lynde
    Faculty of Medicine, University of Toronto, Toronto, Canada
    Skin Therapy Lett 11:1-6. 2006
    b>Hyperpigmentation disorders of the skin are common and can be the source of significant psychosocial distress for patients. The most common of these disorders are melasma and postinflammatory hyperpigmentation...
  79. ncbi Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine
    Donald L Bissett
    Procter and Gamble Company, Cincinnati, Ohio 45252, USA
    J Cosmet Dermatol 6:20-6. 2007
    ..It thus has a potential to reduce hyperpigmentation via topical use...
  80. ncbi A girl with cutaneous hyperpigmentation, café au lait spots and ring chromosome 15 without significant deletion
    E Morava
    University of Pecs, Medical Faculty, Department of Medical Genetics and Child Development, Pecs, 7623 Hungary
    Genet Couns 14:337-42. 2003
    ..3) and within 300 kb of the end of the chromosome, indicating no deletion of functional genes on 15q. Hyperpigmentation and café au lait spots are rare signs in ring chromosome syndromes, but with r(15) syndrome, café au lait ..
  81. ncbi Complications of therapy in cancer patients: Case 1. Paronychia and skin hyperpigmentation induced by gefitinib in advanced non-small-cell lung cancer
    Gee Chen Chang
    Taichung Veterans General Hospital and Chung Shan Medical University, Taiwan
    J Clin Oncol 22:4646-8. 2004
  82. ncbi Topical agents used in the management of hyperpigmentation
    R M Halder
    Department of Dermatology, Howard University, Washington DC, USA
    Skin Therapy Lett 9:1-3. 2004
    Disorders of hyperpigmentation are difficult to treat, particularly in dark-skinned individuals...
  83. ncbi Aloesin inhibits hyperpigmentation induced by UV radiation
    S Choi
    Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea
    Clin Exp Dermatol 27:513-5. 2002
    Skin hyperpigmentation is caused by the overproduction of melanin pigment, which is synthesized by the action of tyrosinase. We recently reported that aloesin inhibits tyrosinase activity...
  84. ncbi The use of hydroquinone with facial laser resurfacing
    M P Goldman
    Dermatology Cosmetic Laser Associates of San Diego County, Inc, 9850 Genesee Ave, Suite 480, La Jolla, CA 92037, USA
    J Cutan Laser Ther 2:73-7. 2000
    One complication of laser resurfacing that is especially common in people with skin types III-VI is hyperpigmentation. This may last for several months after the laser resurfacing procedure.
  85. ncbi Postinflammatory hyperpigmentation: a common but troubling condition
    Nicole L Lacz
    Dermatology, New Jersey Medical School, Newark, NJ, USA
    Int J Dermatol 43:362-5. 2004
  86. ncbi A case of localized lichen planus pigmentosus on the thigh
    Kyoung Jin Kim
    J Dermatol 29:242-3. 2002
  87. ncbi Comparative efficacy and safety of deoxyarbutin, a new tyrosinase-inhibiting agent
    Saja H Hamed
    University of Cincinnati College of Pharmacy, Cincinnati, OH 45267, USA
    J Cosmet Sci 57:291-308. 2006
    ..These results demonstrate that dA is a potentially safe, effective, and reversible tyrosinase inhibitor...
  88. doi A pigmented, hemorrhagic genital wart: clinical, dermoscopic, and histopathologic features
    Fezal Ozdemir
    Arch Dermatol 144:1072-3. 2008
  89. ncbi Complications of chemical resurfacing
    H J Brody
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
    Dermatol Clin 19:427-38, vii-viii. 2001
    ..A thorough understanding of the concepts involved will enable early treatment and avoidance of permanent sequelae, such as pigmentary dyschromias, infection, or scarring...
  90. ncbi Erythromelanosis follicularis faciei et colli associated with keratosis pilaris in two brothers
    Aylin Turel Ermertcan
    Department of Dermatology, Medical Faculty of Celal Bayar University, Manisa, Turkey
    Pediatr Dermatol 23:31-4. 2006
    Erythromelanosis follicularis faciei et colli is characterized by well-demarcated erythema, hyperpigmentation, and follicular papules. Since the original description, it has seldom been reported in the literature...
  91. ncbi Erythromelanosis follicularis faciei et colli: relationship with keratosis pilaris
    M Augustine
    Department of Dermatology, St John s Medical College Hospital, Bangalore, Karnataka, India
    Indian J Dermatol Venereol Leprol 74:47-9. 2008
    Erythromelanosis follicularis faciei et colli (EFF) is an unusual condition characterized by the triad of hyperpigmentation, follicular plugging and erythema of face and neck...
  92. ncbi A case of idiopathic eruptive macular pigmentation
    Tae Young Yoon
    J Dermatol 31:440-1. 2004
  93. ncbi The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
    T Hakozaki
    Research and Development Department, Procter and Gamble Far East, Inc, Kobe Technical Center 7F, Naka 1 17, Koyo cho, Higashinada ku, Japan
    Br J Dermatol 147:20-31. 2002
    Cutaneous hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin colour. Thus, there is a need for the development of skin lightening agents. Niacinamide is a possible candidate.
  94. ncbi Skin lightening preparations and the hydroquinone controversy
    Zoe Diana Draelos
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Dermatol Ther 20:308-13. 2007
    ..I-III require local pigment lightening for the treatment of hormonally induced melasma and postinflammatory hyperpigmentation caused by acne and trauma...
  95. ncbi Chronic heat-induced skin lesions (erythema ab Igne): ultrastructural studies
    V Cavallari
    Institute of Ultrastructural Pathology, University of Messina, Italy
    Ultrastruct Pathol 25:93-7. 2001
    ..This condition is presumably more benign than the ultraviolet exposure. The association of EI and premalignant skin lesions, though occasionally described, seems relatively infrequent...
  96. ncbi Hair removal with the 3-msec alexandrite laser in patients with skin types IV-VI: efficacy, safety, and the role of topical corticosteroids in preventing side effects
    Mohammed S Aldraibi
    King Abdulaziz University, Jeddah, Saudi Arabia
    J Drugs Dermatol 6:60-6. 2007
    ..The abundance of melanin in the epidermis of patients with dark skin color has always been regarded as hazardous due to the increased incidence of side effects in this patient population...
  97. ncbi Graphic analysis of the relationship between skin colour change and variations in the amounts of melanin and haemoglobin
    H Takiwaki
    Department of Dermatology, The University of Tokushima, School of Medicine, Tokushima 770 8503, Japan
    Skin Res Technol 8:78-83. 2002
    ..The aim of this study was to examine whether a* and L* can be used as specific scales to indicate the amount of haemoglobin and melanin, respectively, in the skin...
  98. ncbi [Reasons for consulting related to skin-bleaching products used by 104 women in Brazzaville]
    A Gathse
    Service de Dermatologie, CHU, BP 32, Brazzaville, Congo
    Bull Soc Pathol Exot 98:387-9. 2005
    ..Acne was the most frequent motive for consulting (24%), followed by the paradoxical peri-orbital hyperpigmentation (21.1%), profuse mycosis (16.3%) and vibices(8.6%)...
  99. ncbi Benzylamide derivative compound attenuates the ultraviolet B-induced hyperpigmentation in the brownish guinea pig skin
    Sang Yoon Choi
    Department of Herbal Pharmacology, Graduate School of East West Medical Science, Kyung Hee University, Seoul 130 701, South Korea
    Biochem Pharmacol 67:707-15. 2004
    ..of synthetic benzylamide compound I (2,6-dimethoxy-N-phenylbenzamide) on the ultraviolet B (UV B)-induced hyperpigmentation of the skin...
  100. ncbi A clinical study of topical Pyratine 6 for improving the appearance of photodamaged skin
    Jerry L McCullough
    University of California, Department of Dermatology, Irvine 92697, USA
    J Drugs Dermatol 7:131-5. 2008
    ..The purpose of this study is to determine the cosmetic efficacy and tolerance of topical Pyratine 6 (0.10%) over 12 weeks for improving the baseline clinical signs and symptoms of photodamaged facial skin...
  101. ncbi Exogenous ochronosis and striae atrophicae following the use of bleaching creams
    Maria Rita Bongiorno
    Department of Dermatology, University of Palermo, Palermo, Italy
    Int J Dermatol 44:112-5. 2005
    ....

Research Grants28

  1. Targeting p53-Dependent Repigmentation in Vitiligo
    TAMARA G TERZIAN; Fiscal Year: 2013
    ..1) The Sooty Foot Ataxia mouse model which expresses a high level of p53 and has a hyperpigmented skin;hyperpigmentation is the opposite process of vitiligo and mimics UV-induced human skin tanning;thus, this high p53 mouse model ..
  2. DNA-PKcs Phosphorylation on Hematopoietic Stem Cells Genome Maintenance
    Benjamin Ping Chi Chen; Fiscal Year: 2013
    ..mice is caused by elevated genotoxic stress as evidenced by increased intestinal crypt apoptosis and skin hyperpigmentation. Although these mice die prematurely, they can be rescued with bone marrow transplantation...
  3. Role of exogenous melatonin in skin biology
    Andrzej T Slominski; Fiscal Year: 2013
    ..g. vitiligo or hyperpigmentation), proliferative processes (including precancerous states, epidermal cancer or even melanoma), UVB-induced ..
  4. Dental outcomes in Fibrous Dysplasia/McCune Albright Syndrome
    Sunday O Akintoye; Fiscal Year: 2013
    ..by polyostotic fibrous dysplasia of bone (FD), endocrine disorders and caf[unreadable]-au-lait skin hyperpigmentation. FD affects craniofacial bones including the jaws in 90% of cases...
  5. L. major infection: Natural history and determinants of resistance
    Afif Ben Salah; Fiscal Year: 2011
    ..3. To develop and validate scales for severity of cutaneous lesions and quality of resulting scars. The scale items include size of the ulcer, color (hypopigmentation, hyperpigmentation, normal skin) and height.
  6. Clinical Basis Investigations into MLS/Leopard Syndrome
    Theresa Pacheco; Fiscal Year: 2007
    Lentigines are common pigmentary by hyperpigmentation secondary to an increased number of melanocytes. Multiple Lentigines Syndrome (MLS) is an inherited disease that results in generalized lentigines...
  7. Mouse Model of Pancreatic Tumorigenesis with Dysregulation of mTOR
    Chongjuan Wei; Fiscal Year: 2009
    ..Germline mutations in LKB1 cause Peutz-Jeghers syndrome (PJS), a disorder characterized by mucocutaneous hyperpigmentation and gastrointestinal hamartomatous polyps which display dysregulation of mTOR signaling...
  8. REGULATION OF NA,K ATPASE BY THE AH RECEPTOR
    Mary Walker; Fiscal Year: 2004
    ..in decreased birth weights, neurological deficits, thyroid hormone alterations, lung auscultation, and hyperpigmentation. The mechanism by which TCDD mediates developmental toxicity has not been elucidated...
  9. NOVEL OLIGOPEPTIDES AS TOPICAL SKIN LIGHTENING AGENTS
    JAMES LEYDA; Fiscal Year: 2001
    ..This natural agent provides a new approach to blocking the formation of melanin, the cause of hyperpigmentation. In both in vitro and in vivo models, the protein effectively inhibits the activity of tyrosinase, a marker ..
  10. NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCIN
    Francois DeLori; Fiscal Year: 2005
    ..correlate with rate or direction of greatest progression of subsequent atrophy, and whether discrete foci of hyperpigmentation consistently exhibit lipofuscin spectra...
  11. DIRECT, NONINVASIVE STUDY OF VENOUS FLOW AND THROMBOSIS
    DONALD STRANDNESS; Fiscal Year: 1999
    Manifestations of the post-thrombotic syndrome, including pain, edema, hyperpigmentation, and ulceration, may develop in as many as two-thirds of patients after an episode of deep venous thrombosis (DVT)...
  12. READING CENTER FOR AMD PREVENTION TRIAL
    Stuart Fine; Fiscal Year: 2006
    ..of AMD (for example, predominant drusen morphology drusen confluence, area of drusen involvement, focal hyperpigmentation, retinal pigment epithelial depigmentation, geographic atrophy...
  13. REACTIVE OXYGEN SPECIES AND ULTRAVIOLET LIGHT DAMAGE
    John Dietrich; Fiscal Year: 1990
    ..2. The ability of CHX 100 and ROS scavengers to attenuate UVL- induced melanocyte hyperplasia and hyperpigmentation. The research is aimed at developing safe, effective topical drugs for the prevention of skin damage ..
  14. PULSED-LASER TREATMENT OF PIGMENTED LESIONS AND TATTOOS
    Robert Goldstein; Fiscal Year: 1990
    ..variation of pulsewidth and wavelength, (4) perform a clinical dose/response study of epidermal and dermal hyperpigmentation using QSRL, and (5) produce and if possible optimize laser-induced leukotrichia (permanent hair bleaching)...
  15. Identify Waardenburg syndrome type 2 loci in man
    JEFFREY MILUNSKY; Fiscal Year: 2005
    ..We will perform a high-density genome scan coupled with linkage disequilibrium analyses on 3 large multigenerational families and multiple smaller families with WS2 to identify candidate gene(s) with mutations causing WS2. ..
  16. Identify genes causing Kabuki Syndrome
    JEFFREY MILUNSKY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  17. RETINAL PATHOPHYSIOLOGY OF INFANTS AND ADULTS
    David Birch; Fiscal Year: 2005
    ..In the mouse models, cone measures will necessarily focus on the b-wave, using monochromatic stimuli, long-duration flashes, and flicker to optimize isolation of cone from rod responses. ..
  18. Dissecting the Molecular Basis of Ocular Albinism type 1
    Maria Vittoria Schiaffino; Fiscal Year: 2007
    ..abstract_text> ..
  19. SPECIAL POPULATIONS NETWORK FOR CANCER CONTROL
    Edith Mitchell; Fiscal Year: 2003
    ..abstract_text> ..
  20. BENEFITS OF TESTOSTERONE ON STRENGTH IN ELDERLY MEN
    Laurence Katznelson; Fiscal Year: 2002
    ..The goal of these studies will be to determine the efficacy and safety of testosterone administration and, additionally, a home-based exercise program on muscle function in older men with relative testosterone insufficiency. ..
  21. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    ....
  22. PHENOLS/CATECHOLS IN OCCUPATIONAL/CONTACT VITILIGO SKIN
    Raymond Boissy; Fiscal Year: 2002
    ....
  23. 2004 National Vitiligo Foundation Scientific Conference
    Raymond Boissy; Fiscal Year: 2004
    ..In addition, mini-symposiums will be organized for each of the sessions. ..
  24. Bilirubin and Photobilirubin: Metabolism & Exretion
    Antony McDonagh; Fiscal Year: 2005
    ..The work will lead to safer more effective treatment of familial hyperbilirubinemia and jaundice in the newborn. ..
  25. CLINICAL TRANSLATIONAL RESEARCH IN DERMATOLOGY
    Sewon Kang; Fiscal Year: 2004
    ..abstract_text> ..
  26. ON THE ROLE OF THE HPS GENE PRODUCT IN MELANOCYTES
    Raymond Boissy; Fiscal Year: 2002
    ..These studies will contribute to our knowledge of cellular trafficking in general and the pathophysiology of HPS in specific. ..
  27. Melanoma Chemoprevention
    Robert Dellavalle; Fiscal Year: 2006
    ..His current career goals are completing a Masters of Science in Public Health and becoming an independent researcher in skin cancer prevention and control. ..