Genomes and Genes
Summary: Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.
Publications241 found, 100 shown here
- Side effects and complications of laser therapyElizabeth I McBurney
Department of Dermatology, Louisiana State University Health Sciences Center, Tulane University School of Medicine, New Orleans, Louisiana, USA
Dermatol Clin 20:165-76. 2002..An informed patient is an important factor in the healing process and contributes to the success of the procedure...
- Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit geneH Maeyama
Department of Gastroenterology, Nagano Red Cross Hospital, Nagano, Japan
Gastroenterology 120:210-5. 2001We describe 2 siblings with multiple gastrointestinal stromal tumors (GISTs) and cutaneous hyperpigmentation. Both had a point mutation of the c-kit gene...
- Laugier and Hunziker pigmentation: a lentiginous proliferation of melanocytesRoger T Moore
Department of Dermatology, Rush Medical College, Rush Presbyterian St Luke s Medical Center, 1653 W Congress Parkway, 507 Kidston, Chicago, IL 60612, USA
J Am Acad Dermatol 50:S70-4. 2004..Further studies are warranted to determine if this pigmentation disorder represents a spectrum of histopathologic change or, in fact, should be renamed mucocutaneous lentiginosis of Laugier and Hunziker...
- Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trialA B Kimball
Harvard Medical School, Boston, MA 02114, USA
Br J Dermatol 162:435-41. 2010..In small clinical studies, niacinamide-containing and NAG-containing formulations reduced the appearance of hyperpigmentation.
- Central role of p53 in the suntan response and pathologic hyperpigmentationRutao Cui
Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cell 128:853-64. 2007..p53 thus functions as a sensor/effector for UV pigmentation, which is a nearly constant environmental exposure. Moreover, this pathway is activated in numerous conditions of pathologic pigmentation and thus mimics the tanning response...
- Role of fibroblast-derived growth factors in regulating hyperpigmentation of solar lentigoD Kovacs
San Gallicano Dermatologic Institute, IRCCS, Via Elio Chianesi 53, Rome 00144, Italy
Br J Dermatol 163:1020-7. 2010..Despite the association of SL to ultraviolet (UV) exposure, the mechanisms underlying the development of these spots are not completely defined...
- Postinflammatory hyperpigmentation: etiologic and therapeutic considerationsValerie D Callender
Callender Skin and Laser Center, 12220 Annapolis Blvd, Glenn Dale, MD 20769, USA
Am J Clin Dermatol 12:87-99. 2011Postinflammatory hyperpigmentation (PIH) is a reactive hypermelanosis and sequela of a variety of inflammatory skin conditions. PIH can have a negative impact on a patient's quality of life, particularly for darker-skinned patients...
- The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilisS Kadono
Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan
J Invest Dermatol 116:571-7. 2001Little is known about the mechanism(s) underlying hyperpigmentation in lentigo senilis...
- Palate hyperpigmentation caused by prolonged use of the anti-malarial chloroquineMário Rodrigues de Melo Filho
Department of Dentistry, State University of Montes Claros, Montes Claros, Minas Gerais, Brazil
Head Neck Pathol 6:48-50. 2012..Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist...
- Postinflammatory hyperpigmentationSusan Taylor
Department of Dermatology, Columbia University, and the Skin of Color Center, St Luke s Roosevelt Hospital Center, New York, NY, USA
J Cutan Med Surg 13:183-91. 2009Postinflammatory hyperpigmentation (PIH) commonly occurs in Fitzpatrick skin types III to VI and can have a considerable impact on quality of life...
- Optimal management of recalcitrant disorders of hyperpigmentation in dark-skinned patientsAlexander J Stratigos
Department of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital for Skin and Venereal Diseases, Athens, Greece
Am J Clin Dermatol 5:161-8. 2004..Hyperpigmented disorders such as melanosis (melasma), post-inflammatory hyperpigmentation, drug-induced hyperpigmentation, and erythema dyschromicum perstans tend to have a prolonged course and, in ..
- Case for diagnosisAna Carolina Figueiredo Pereira Cherobin
Department of Dermatology, Hospital das Clinicas, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
An Bras Dermatol 87:151-2. 2012..Its etiology is unknown and there is no specific treatment for the condition. We report a case of ashy dermatosis in a 41-year-old patient with extensive lesions on the trunk and limbs...
- Postinflammatory hyperpigmentation secondary to external insult: an overview of the quantitative analysis of pigmentationSonia A Lamel
Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
Cutan Ocul Toxicol 32:67-71. 2013Despite new technologies, few studies have quantified changes in melanocyte numbers associated with postinflammatory hyperpigmentation (PIH) secondary to exogenous causes.
- Addison's disease in Africa--a teaching hospital experienceS Soule
Department of Medicine, University of Cape Town, Cape Town, South Africa
Clin Endocrinol (Oxf) 50:115-20. 1999....
- Flagellate hyperpigmentation following intralesional bleomycin treatment of verruca plantarisAlexander Abess
Department of Dermatology, Naval Medical Center San Diego, San Diego, CA, USA
Arch Dermatol 139:337-9. 2003Flagellate hyperpigmentation is a well-documented complication of systemic bleomycin sulfate therapy when using doses of 100 U or more as an antineoplastic agent...
- The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1L Manaka
Department of Dermatology, Tokyo Women's Medical University, Japan
Br J Dermatol 145:895-903. 2001..a strong keratinocyte-derived mitogen and melanogen for human melanocytes, is intrinsically involved in the hyperpigmentation mechanism of SK...
- Management of hyperpigmentation in darker racial ethnic groupsPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA
Semin Cutan Med Surg 28:77-85. 2009Dyschromias, in particular hyperpigmentation, are major issues of concern for people of color...
- Mixed hyperpigmentation and hypopigmentation of iris and choroid in Chediak-Higashi syndromeMin Chieh Ho
Department of Ophthalmology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan
J AAPOS 17:558-60. 2013An 8-year-old Taiwanese girl presented with hyperpigmentation and scattered hypopigmentation in her irides and choroids. Her skin showed hyperpigmentation with speckled hypopigmentation over cheeks and sun-exposed areas...
- Hyperpigmentation: an overview of the common afflictionsKimberly A Cayce
Eastern North Carolina University, Greenville, NC, USA
Dermatol Nurs 16:401-6, 413-6; quiz 417. 2004b>Hyperpigmentation disorders of the skin are common. Three of the more common forms include melasma, lentigines, and post-inflammatory hyperpigmentation. Significant negative psychological consequences can result...
- Photodistribution of blue-gray hyperpigmentation after amiodarone treatment: molecular characterization of amiodarone in the skinAlfred Ammoury
Service de Dermatologie, Centre Hospitalier Universitaire de Toulouse, Hopital Purpan, 31059 Toulouse Cedex, France
Arch Dermatol 144:92-6. 2008For decades, the photodistributed blue-gray skin hyperpigmentation observed after amiodarone therapy was presumably attributed to dermal lipofuscinosis...
- Combined therapy using Q-switched ruby laser and bleaching treatment with tretinoin and hydroquinone for periorbital skin hyperpigmentation in AsiansAkira Momosawa
Department of Plastic, Reconstructive, and Aesthetic Surgery, Kyorin University School of Medicine, Tokyo, Japan
Plast Reconstr Surg 121:282-8. 2008Periorbital skin hyperpigmentation, so-called dark circles, is of major concern for many people...
- Hypomelanosis of ito-whorled hyperpigmentation combination: a mirror image presentationRajoo Thapa
Department of Pediatrics and Pediatric Dermatology Unit, The Institute of Child Health, Kolkata, West Bengal, India
Pediatr Dermatol 24:572-3. 2007....
- Chemical and instrumental approaches to treat hyperpigmentationStefania Briganti
San Gallicano Dermatological Institute, Via Elio Chianesi, Rome, Italy
Pigment Cell Res 16:101-10. 2003Many modalities of treatment for acquired skin hyperpigmentation are available including chemical agents or physical therapies, but none are completely satisfactory...
- Two Japanese cases of lichen planus pigmentosus-inversusAki Kashima
Department of Dermatology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
Int J Dermatol 46:740-2. 2007..2B). Both the epidermis and the upper dermis contained CD1a(+) cells (Fig. 2C). The keratinocytes focally and weakly expressed HLA-DR (Fig. 2D). These findings were identical in samples from both patients...
- A new type of minocycline-induced cutaneous hyperpigmentationR W Mouton
Department of Dermatology, Faculty of Health Sciences, University of Stellenbosch and Tygerberg Hospital, PO Box 19063, Tygerberg 7505, South Africa
Clin Exp Dermatol 29:8-14. 2004..Iron was absent. This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to ..
- Effective and safe use of lasers, light sources, and radiofrequency devices in the clinical management of Asian patients with selected dermatosesHenry H L Chan
University of Hong Kong, Hong Kong
Lasers Surg Med 37:179-85. 2005..The use of lasers, light sources, and radiofrequency devices in Asian patients differs from their use in Caucasians in several respects...
- Lichen planus pigmentosus-inversusL Pock
Department of Dermatology and Venerology, Charles University 2nd Medical School, Motol University Hospital, Prague, Czech Republic
J Eur Acad Dermatol Venereol 15:452-4. 2001..Because of the highly characteristic inverse location of the lesions in our patients we propose the designation LPP-inversus for this variant of the disease...
- Squamous papilloma with hyperpigmentation in the skin graft of the neovagina in Rokitansky syndrome: literature review of benign and malignant lesions of the neovaginaMuhammad T Idrees
Department of Pathology, Mount Sinai Medical Center, New York, New York, USA
J Pediatr Adolesc Gynecol 22:e148-55. 2009..It is rare for a benign or malignant neoplasm to develop in a neovagina...
- Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathwaysLi Chen Wu
Department of Applied Chemistry, National Chi Nan University, Puli, Nantou, 545, Taiwan
J Biomed Sci 18:74. 2011..is one of the essential defense mechanisms against oxidative stress or UV irradiation; however, abnormal hyperpigmentation in human skin may pose a serious aesthetic problem...
- Evaluation of a hydroquinone-free skin brightening product using in vitro inhibition of melanogenesis and clinical reduction of ultraviolet-induced hyperpigmentationElizabeth T T Makino
SkinMedica, an Allergan Company, Carlsbad, CA, USA
J Drugs Dermatol 12:s16-20. 2013..remains the only prescription product available in the United States for the treatment of generalized facial hyperpigmentation. Irritation and the risk of exogenous ochronosis are the main adverse effects for concern...
- Inflammation drives wound hyperpigmentation in zebrafish by recruiting pigment cells to sites of tissue damageMathieu Lévesque
School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK
Dis Model Mech 6:508-15. 2013..Tissue damage and repair also frequently lead to alterations in skin pigmentation, in particular to wound hyperpigmentation. In this study, we describe a model of wound hyperpigmentation in the translucent zebrafish larva, where we ..
- 4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentationL Kolbe
Research and Development, Beiersdorf AG, Hamburg, Germany
J Eur Acad Dermatol Venereol 27:19-23. 2013..The most prominent target for inhibitors of hyperpigmentation is tyrosinase, the key regulator of melanin production...
- Lichen planus pigmentosus-inversus: case report and review of an unusual entityErich Gaertner
SaraPath Diagnostics, Sarasota, Florida, USA
Dermatol Online J 18:11. 2012..The case well highlights this unusual condition and represents the first case reported in the United States...
- [Capecitabine-induced hyperpigmentation]C Vázquez-Bayo
Servicio de Dermatologia, Hospital Universitario Reina Sofia, Cordoba, Espana
Actas Dermosifiliogr 98:491-3. 2007..adverse effects have been recognized, among which we find the muco-cutaneous ones and, specifically, hyperpigmentation. We report a case of localized cutaneous hyperpigmentation secondary to capecitabine in a woman that ..
- Reversible cutaneous hyperpigmentation and nails with white hair due to vitamin B12 deficiencyShiro Niiyama
Department of Dermatology, Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan
Eur J Dermatol 17:551-2. 2007
- Hypopigmented macular amyloidosis with or without hyperpigmentationM S L Ho
Department of Dermatology, National Skin Centre, Singapore
Clin Exp Dermatol 34:e547-51. 2009..of PCA, which shared common features of hypopigmentation as a predominant feature with or without reticular hyperpigmentation, no itching, adult onset and dermal papillary amyloid deposition...
- Images in clinical medicine. Minocycline-induced hyperpigmentationAdrian N Holm
Mayo Clinic, Rochester, MN, USA
N Engl J Med 355:e23. 2006
- Hyperpigmentation: a review of common treatment optionsKimberly A Cayce
Center for Dermatology Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Drugs Dermatol 3:668-73. 2004b>Hyperpigmentation disorders are common and include a multitude of forms. They are typically divided into three large categories: dermal, epidermal, or mixed, depending on the site of abnormality...
- Antineoplastic agent-associated serpentine supravenous hyperpigmentation: superficial venous system hyperpigmentation following intravenous chemotherapyElizabeth R C Geddes
University of Texas Houston Medical School, Department of Dermatology, Houston, TX, USA
South Med J 103:231-5. 2010To review the clinical characteristics and associated antineoplastic agents in patients who developed hyperpigmentation of the superficial venous system after chemotherapy.
- The mechanism of action and clinical benefits of soy for the treatment of hyperpigmentationJames Leyden
The University of Pennsylvania, Philadelphia, PA, USA
Int J Dermatol 50:470-7. 2011b>Hyperpigmentation disorders are common and diverse conditions that may require treatment for medical and/or cosmetic reasons...
- Hand-foot hyperpigmentation skin lesions associated with combination gemcitabine-carboplatin (GemCarbo) therapyRoman L Kleynberg
Department of Hematology Oncology, The University of Toledo College of Medicine, OH 43614, USA
Am J Ther 18:e261-3. 2011..We report an unusual case of hand-foot hyperpigmentation after the use of GemCarbo therapy on a man with stage IV non-small cell lung carcinoma...
- Natural options for the management of hyperpigmentationJ J Leyden
University of Pennsylvania, Philadelphia, PA, USA
J Eur Acad Dermatol Venereol 25:1140-5. 2011....
- Hydroxychloroquine-induced hyperpigmentation: the staining patternPuja K Puri
Department of Dermatology Dermatopathology, Geisinger Medical Center, Danville, PA 17822, USA
J Cutan Pathol 35:1134-7. 2008We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female (case 1) and a 78-year-old female (case 2), both receiving 400 mg per day...
- Prospective study on the treatment of postburn hyperpigmentation by intense pulsed lightWai Sun Ho
Division of Plastic and Reconstructive Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Lasers Surg Med 32:42-5. 2003Postburn hyperpigmentation is a common phenomenon among Asian especially over grafted areas and sometimes over donor sites and healed wounds without skin graft...
- Café-au-lait spots in neurofibromatosis type 1 and in healthy control individuals: hyperpigmentation of a different kind?Sofie De Schepper
Department of Dermatology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium
Arch Dermatol Res 297:439-49. 2006..We conclude that SCF is an important cytokine in NF1 skin, but that additional (growth) factors and/or genetic mechanisms are needed to induce NF1-specific CALM hyperpigmentation.
- Capecitabine-induced hand-foot syndrome and cutaneous hyperpigmentation in an elderly vitiligo patientR Tavares-Bello
J Eur Acad Dermatol Venereol 21:1434-5. 2007
- Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled studyPearl Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
Cutis 77:45-50. 2006..The present investigation assessed tazarotene 0.1% cream for the treatment of postinflammatory hyperpigmentation (PIH) in a double-blind, randomized, vehicle-controlled study of 74 patients from darker racial ethnic ..
- Managing common dermatoses in skin of colorMarcelyn K Coley
Skin of Color Center, Department of Dermatology, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
Semin Cutan Med Surg 28:63-70. 2009..part as a result of the sequelae often associated with the conditions in their own right - postinflammatory hyperpigmentation and scarring - and potential iatrogenic adverse effects that may occur during treatment...
- Ethnic considerations in the treatment of Hispanic and Latin-American patients with hyperpigmentationD Hexsel
School of Medicine, University of Passo Fundo, Rio Grande do Sol, Brazil
Br J Dermatol 156:7-12. 2006..of skin phototypes and pigmentation and are prone to an increased incidence of melasma and post-inflammatory hyperpigmentation. Little research has been conducted to evaluate the frequency, course, effects, tolerability and treatment ..
- A retrospective study on the efficacy and complications of Q-switched alexandrite laser in the treatment of acquired bilateral nevus of Ota-like maculesA Y Lam
Division of Dermatology, Department of Medicine, University of Hong Kong
Dermatol Surg 27:937-41; discussion 941-2. 2001..of Ota-like macules (ABNOM), or Hori's macules, is a common Asian condition that is characterized by bluish hyperpigmentation in the bilateral malar regions...
- A kindred with familial progressive hyperpigmentation-like disorder: implication of fibroblast-derived growth factors in pigmentationGiorgia Cardinali
San Gallicano Dermatological Institute, IRCCS, Via Elio Chianesi 53, 00144 Rome, Italy
Eur J Dermatol 19:469-73. 2009..The patients (father and daughter) had had a widespread hyperpigmentation since early life which then progressively worsened with the appearance of hyperpigmented macules, café-au-..
- Melanoma hyperpigmentation is strongly associated with KIT alterationsJulie M Wu
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Am J Dermatopathol 31:619-25. 2009..sun damage, tumor infiltrating lymphocytes, melanoma in situ, vertical growth phase (VGP), location, and hyperpigmentation. Twenty-eight cases demonstrated 3+ membranous staining...
- Laugier-Hunziker-Baran syndromeKaori Yago
Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:e20-5. 2008..The differential diagnosis of oral and pigmented lesions between Laugier-Hunziker-Baran syndrome and other disorders, Peutz-Jeghers syndrome in particular, requires our utmost consideration...
- Laugier-Hunziker syndrome associated with actinic lichen planusS Aytekin
J Eur Acad Dermatol Venereol 18:221-3. 2004
- Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentationZhi Qiang Wang
State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
Am J Hum Genet 84:672-7. 2009Familial progressive hyperpigmentation (FPH) is an autosomal-dominantly inherited disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age...
- Progressive hyperpigmentation and generalized lentiginosis without associated systemic symptoms: a rare hereditary pigmentation disorder in south-east GermanyLivia Zanardo
Department of Dermatology, University of Regensburg, Germany
Acta Derm Venereol 84:57-60. 2004Familial progressive hyperpigmentation is rarely described in the literature. We report on five patients from three different families presenting with a peculiar progressive pigmentary disorder...
- Quantitative evaluation of skin condition in an epidemiological survey of females living in northern versus southern JapanG G Hillebrand
Procter and Gamble, One Procter and Gamble Plaza, Cincinnati, OH 45202 3315, USA
J Dermatol Sci 27:S42-52. 2001..high resolution digital imaging followed by computer analysis of facial images for facial skin wrinkling and hyperpigmentation; silicone skin replicas followed by Moiré interferometry for facial skin surface roughness (texture); the ..
- Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative studyVijay Kumar Garg
Department of Dermatology, Venereology and Leprology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India
Dermatol Surg 35:59-65. 2009Many clinicians have used glycolic acid (GA) peels for facial acne, scarring, and hyperpigmentation, mainly in lighter skin types...
- Addison's diseaseLynnette K Nieman
Reproductive and Biology Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Clin Dermatol 24:276-80. 2006..The cutaneous manifestations include darkening of the skin especially in sun-exposed areas and hyperpigmentation of the palmar creases, frictional surfaces, vermilion border, recent scars, genital skin, and oral mucosa...
- Treatment of Laugier-Hunziker syndrome with the Q-switched alexandrite laser in 22 Chinese patientsYa Gang Zuo
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
Arch Dermatol Res 302:125-30. 2010..Our study has also demonstrated QSAL to be highly effective and safe in the treatment of LHS...
- Laugier-Hunziker syndrome: a rare cause of mucocutaneous pigmentationT Sabesan
Department of Oral and Maxillofacial Surgery, Poole General Hospital, Longfleet Road, Poole, Dorset BH15 2JB, UK
Br J Oral Maxillofac Surg 44:320-1. 2006..An 80-year-old white woman presented with brown pigmentation on both sides of the buccal mucosa and lower lip and patchy freckling in her nails, which was diagnosed as Laugier-Hunziker syndrome...
- Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndromeA K Lampe
J Med Genet 40:e77. 2003
- Idiopathic lenticular mucocutaneous pigmentation (Laugier-Hunziker syndrome): a report of a caseMaria Siponen
Univeristy of Oulu, Oulu University Hospital, Oulu, Finland
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:288-92. 2003Laugier-Hunziker syndrome (LHS) is an acquired, benign, macular hyperpigmentation of the lips and oral mucosa, often associated with pigmentation of the nails...
- Melanin pigmentary disorders: treatment updateJean Paul Ortonne
Service de Dermatologie, Hôpital L Archet 2, Nice, France
Dermatol Clin 23:209-26. 2005..The treatment of hypomelanotic disorders is still often disappointing, but new therapeutic options provide encouraging results...
- Novel c-KIT germline mutation in a family with gastrointestinal stromal tumors and cutaneous hyperpigmentationMiguel Carballo
Laboratori de Biologia i Genetica Molecular, Servei de Laboratori, Hospital de Terrassa, Terrassa, Spain
Am J Med Genet A 132:361-4. 2005..We report a familial case of GIST with cutaneous hyperpigmentation associated with a novel germline mutation in the c-KIT gene...
- Improved contrast of peripapillary hyperpigmentation using polarization analysisMariane B Mellem-Kairala
Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA
Invest Ophthalmol Vis Sci 46:1099-106. 2005To improve detection and quantification of peripapillary hyperpigmentation, associated with aging, open-angle glaucoma, and age-related macular degeneration.
- Iris hyperpigmentation in a Chinese family with ocular albinism and the GPR143 mutationXueshan Xiao
Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
Am J Med Genet A 149:1786-8. 2009..Here, we report on a Chinese family with OA1 and partial deletion of GPR143. An unusual phenotype of iris hyperpigmentation without translucency was observed in the male patient and the carrier mother...
- Prayer marksAbdullah A Abanmi
Dermatology Department, Research Center, Riyadh Al Kharj Armed Forces Hospital, PO Box 7897, Riyadh 11159, Saudi Arabia
Int J Dermatol 41:411-4. 2002..marks (PMs) are asymptomatic, chronic skin changes that consist mainly of thickening, lichenification, and hyperpigmentation, and develop over a long period of time as a consequence of repeated, extended pressure on bony prominences ..
- Minocycline-induced hyperpigmentation in rheumatoid arthritisBrian T Fay
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 2055, USA
J Clin Rheumatol 14:17-20. 2008Minocycline is recognized as an effective, well-tolerated therapy in rheumatoid arthritis (RA), although its use has been associated with the development of cutaneous hyperpigmentation.
- Application of a combined sulphorhodamine B and melanin assay to the evaluation of Chinese medicines and their constituent compounds for hyperpigmentation treatmentRosanna Y Y Lam
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
J Ethnopharmacol 132:274-9. 2010To investigate the efficacy of traditional Chinese medicine (TCM) in the treatment of hyperpigmentation problems, extracts of herbs selected based on traditional Chinese medical literature were screened.
- Common hyperpigmentation disorders in adults: Part II. Melanoma, seborrheic keratoses, acanthosis nigricans, melasma, diabetic dermopathy, tinea versicolor, and postinflammatory hyperpigmentationDaniel L Stulberg
Utah Valley Family Practice Residency Program, Provo, Utah, USA
Am Fam Physician 68:1963-8. 2003..Melasma is a facial hyperpigmentation resulting from the stimulation of melanocytes by endogenous or exogenous estrogen...
- Squalene as a target molecule in skin hyperpigmentation caused by singlet oxygenAkemi Ryu
Research Laboratories, KOSE Corporation, Azusawa, Itabashi ku, Tokyo, Japan
Biol Pharm Bull 32:1504-9. 2009..Furthermore, we found that topical application of squalene peroxide induced skin hyperpigmentation through increasing prostaglandin E(2) release from keratinocytes in guinea pigs...
- Hyperpigmentation and melasmaD Rigopoulos
Department of Dermatology, A Sygros Hospital, University of Athens, Athens, Greece
J Cosmet Dermatol 6:195-202. 2007..common cause of facial pigmentation, there are many other forms including drug-induced and postinflammatory hyperpigmentation. We review pathogenesis, clinical and histopathological data, effect on quality of life, and treatment ..
- Percutaneous collagen induction: minimally invasive skin rejuvenation without risk of hyperpigmentation-fact or fiction?Mathias C Aust
Klinik für Plastische, Hand und Wiederherstellungschirurgie, Medizinische Hochschule Hannover, Hannover, Germany
Plast Reconstr Surg 122:1553-63. 2008..It was recently shown in clinical trials that percutaneous collagen induction therapy is an alternative for safely treating wrinkles and scars and for smoothening the skin without the risk of dyspigmentation...
- The prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in AsiansHenry H L Chan
Division of Dermatology, Department of Medicine, University of Hong Kong, Hong Kong SAR, China
Lasers Surg Med 39:381-5. 2007..However, in Asians, post-inflammatory hyperpigmentation (PIH) is a common adverse effect of laser resurfacing...
- Persistent cutaneous hyperpigmentation after tyrosine kinase inhibition with imatinib for GISTDoru T Alexandrescu
Georgetown Dermatology, Washington, DC, USA
Dermatol Online J 14:7. 2008..b>Hyperpigmentation of the skin is a less frequent side effect...
- Morphologic changes of acquired melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") assessed by dermoscopyMaria A Pizzichetta
Division of Medical Oncology C Preventive Oncology, National Cancer Institute, Aviano, Italy
Arch Dermatol 142:479-83. 2006Melanocytic nevi with eccentric foci of hyperpigmentation ("Bolognia sign") can be considered as a melanoma-simulating type of acquired melanocytic nevus...
- Topical treatments for melasma and postinflammatory hyperpigmentationC B Lynde
Faculty of Medicine, University of Toronto, Toronto, Canada
Skin Therapy Lett 11:1-6. 2006b>Hyperpigmentation disorders of the skin are common and can be the source of significant psychosocial distress for patients. The most common of these disorders are melasma and postinflammatory hyperpigmentation...
- Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamineDonald L Bissett
Procter and Gamble Company, Cincinnati, Ohio 45252, USA
J Cosmet Dermatol 6:20-6. 2007..It thus has a potential to reduce hyperpigmentation via topical use...
- A girl with cutaneous hyperpigmentation, café au lait spots and ring chromosome 15 without significant deletionE Morava
University of Pecs, Medical Faculty, Department of Medical Genetics and Child Development, Pecs, 7623 Hungary
Genet Couns 14:337-42. 2003..3) and within 300 kb of the end of the chromosome, indicating no deletion of functional genes on 15q. Hyperpigmentation and café au lait spots are rare signs in ring chromosome syndromes, but with r(15) syndrome, café au lait ..
- Complications of therapy in cancer patients: Case 1. Paronychia and skin hyperpigmentation induced by gefitinib in advanced non-small-cell lung cancerGee Chen Chang
Taichung Veterans General Hospital and Chung Shan Medical University, Taiwan
J Clin Oncol 22:4646-8. 2004
- Topical agents used in the management of hyperpigmentationR M Halder
Department of Dermatology, Howard University, Washington DC, USA
Skin Therapy Lett 9:1-3. 2004Disorders of hyperpigmentation are difficult to treat, particularly in dark-skinned individuals...
- Aloesin inhibits hyperpigmentation induced by UV radiationS Choi
Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea
Clin Exp Dermatol 27:513-5. 2002Skin hyperpigmentation is caused by the overproduction of melanin pigment, which is synthesized by the action of tyrosinase. We recently reported that aloesin inhibits tyrosinase activity...
- The use of hydroquinone with facial laser resurfacingM P Goldman
Dermatology Cosmetic Laser Associates of San Diego County, Inc, 9850 Genesee Ave, Suite 480, La Jolla, CA 92037, USA
J Cutan Laser Ther 2:73-7. 2000One complication of laser resurfacing that is especially common in people with skin types III-VI is hyperpigmentation. This may last for several months after the laser resurfacing procedure.
- Postinflammatory hyperpigmentation: a common but troubling conditionNicole L Lacz
Dermatology, New Jersey Medical School, Newark, NJ, USA
Int J Dermatol 43:362-5. 2004
- A case of localized lichen planus pigmentosus on the thighKyoung Jin Kim
J Dermatol 29:242-3. 2002
- Comparative efficacy and safety of deoxyarbutin, a new tyrosinase-inhibiting agentSaja H Hamed
University of Cincinnati College of Pharmacy, Cincinnati, OH 45267, USA
J Cosmet Sci 57:291-308. 2006..These results demonstrate that dA is a potentially safe, effective, and reversible tyrosinase inhibitor...
- A pigmented, hemorrhagic genital wart: clinical, dermoscopic, and histopathologic featuresFezal Ozdemir
Arch Dermatol 144:1072-3. 2008
- Complications of chemical resurfacingH J Brody
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
Dermatol Clin 19:427-38, vii-viii. 2001..A thorough understanding of the concepts involved will enable early treatment and avoidance of permanent sequelae, such as pigmentary dyschromias, infection, or scarring...
- Erythromelanosis follicularis faciei et colli associated with keratosis pilaris in two brothersAylin Turel Ermertcan
Department of Dermatology, Medical Faculty of Celal Bayar University, Manisa, Turkey
Pediatr Dermatol 23:31-4. 2006Erythromelanosis follicularis faciei et colli is characterized by well-demarcated erythema, hyperpigmentation, and follicular papules. Since the original description, it has seldom been reported in the literature...
- Erythromelanosis follicularis faciei et colli: relationship with keratosis pilarisM Augustine
Department of Dermatology, St John s Medical College Hospital, Bangalore, Karnataka, India
Indian J Dermatol Venereol Leprol 74:47-9. 2008Erythromelanosis follicularis faciei et colli (EFF) is an unusual condition characterized by the triad of hyperpigmentation, follicular plugging and erythema of face and neck...
- A case of idiopathic eruptive macular pigmentationTae Young Yoon
J Dermatol 31:440-1. 2004
- The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transferT Hakozaki
Research and Development Department, Procter and Gamble Far East, Inc, Kobe Technical Center 7F, Naka 1 17, Koyo cho, Higashinada ku, Japan
Br J Dermatol 147:20-31. 2002Cutaneous hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin colour. Thus, there is a need for the development of skin lightening agents. Niacinamide is a possible candidate.
- Skin lightening preparations and the hydroquinone controversyZoe Diana Draelos
Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Dermatol Ther 20:308-13. 2007..I-III require local pigment lightening for the treatment of hormonally induced melasma and postinflammatory hyperpigmentation caused by acne and trauma...
- Chronic heat-induced skin lesions (erythema ab Igne): ultrastructural studiesV Cavallari
Institute of Ultrastructural Pathology, University of Messina, Italy
Ultrastruct Pathol 25:93-7. 2001..This condition is presumably more benign than the ultraviolet exposure. The association of EI and premalignant skin lesions, though occasionally described, seems relatively infrequent...
- Hair removal with the 3-msec alexandrite laser in patients with skin types IV-VI: efficacy, safety, and the role of topical corticosteroids in preventing side effectsMohammed S Aldraibi
King Abdulaziz University, Jeddah, Saudi Arabia
J Drugs Dermatol 6:60-6. 2007..The abundance of melanin in the epidermis of patients with dark skin color has always been regarded as hazardous due to the increased incidence of side effects in this patient population...
- Graphic analysis of the relationship between skin colour change and variations in the amounts of melanin and haemoglobinH Takiwaki
Department of Dermatology, The University of Tokushima, School of Medicine, Tokushima 770 8503, Japan
Skin Res Technol 8:78-83. 2002..The aim of this study was to examine whether a* and L* can be used as specific scales to indicate the amount of haemoglobin and melanin, respectively, in the skin...
- [Reasons for consulting related to skin-bleaching products used by 104 women in Brazzaville]A Gathse
Service de Dermatologie, CHU, BP 32, Brazzaville, Congo
Bull Soc Pathol Exot 98:387-9. 2005..Acne was the most frequent motive for consulting (24%), followed by the paradoxical peri-orbital hyperpigmentation (21.1%), profuse mycosis (16.3%) and vibices(8.6%)...
- Benzylamide derivative compound attenuates the ultraviolet B-induced hyperpigmentation in the brownish guinea pig skinSang Yoon Choi
Department of Herbal Pharmacology, Graduate School of East West Medical Science, Kyung Hee University, Seoul 130 701, South Korea
Biochem Pharmacol 67:707-15. 2004..of synthetic benzylamide compound I (2,6-dimethoxy-N-phenylbenzamide) on the ultraviolet B (UV B)-induced hyperpigmentation of the skin...
- A clinical study of topical Pyratine 6 for improving the appearance of photodamaged skinJerry L McCullough
University of California, Department of Dermatology, Irvine 92697, USA
J Drugs Dermatol 7:131-5. 2008..The purpose of this study is to determine the cosmetic efficacy and tolerance of topical Pyratine 6 (0.10%) over 12 weeks for improving the baseline clinical signs and symptoms of photodamaged facial skin...
- Exogenous ochronosis and striae atrophicae following the use of bleaching creamsMaria Rita Bongiorno
Department of Dermatology, University of Palermo, Palermo, Italy
Int J Dermatol 44:112-5. 2005....
- Targeting p53-Dependent Repigmentation in VitiligoTAMARA G TERZIAN; Fiscal Year: 2013..1) The Sooty Foot Ataxia mouse model which expresses a high level of p53 and has a hyperpigmented skin;hyperpigmentation is the opposite process of vitiligo and mimics UV-induced human skin tanning;thus, this high p53 mouse model ..
- DNA-PKcs Phosphorylation on Hematopoietic Stem Cells Genome MaintenanceBenjamin Ping Chi Chen; Fiscal Year: 2013..mice is caused by elevated genotoxic stress as evidenced by increased intestinal crypt apoptosis and skin hyperpigmentation. Although these mice die prematurely, they can be rescued with bone marrow transplantation...
- Role of exogenous melatonin in skin biologyAndrzej T Slominski; Fiscal Year: 2013..g. vitiligo or hyperpigmentation), proliferative processes (including precancerous states, epidermal cancer or even melanoma), UVB-induced ..
- Dental outcomes in Fibrous Dysplasia/McCune Albright SyndromeSunday O Akintoye; Fiscal Year: 2013..by polyostotic fibrous dysplasia of bone (FD), endocrine disorders and caf[unreadable]-au-lait skin hyperpigmentation. FD affects craniofacial bones including the jaws in 90% of cases...
- L. major infection: Natural history and determinants of resistanceAfif Ben Salah; Fiscal Year: 2011..3. To develop and validate scales for severity of cutaneous lesions and quality of resulting scars. The scale items include size of the ulcer, color (hypopigmentation, hyperpigmentation, normal skin) and height.
- Clinical Basis Investigations into MLS/Leopard SyndromeTheresa Pacheco; Fiscal Year: 2007Lentigines are common pigmentary by hyperpigmentation secondary to an increased number of melanocytes. Multiple Lentigines Syndrome (MLS) is an inherited disease that results in generalized lentigines...
- Mouse Model of Pancreatic Tumorigenesis with Dysregulation of mTORChongjuan Wei; Fiscal Year: 2009..Germline mutations in LKB1 cause Peutz-Jeghers syndrome (PJS), a disorder characterized by mucocutaneous hyperpigmentation and gastrointestinal hamartomatous polyps which display dysregulation of mTOR signaling...
- REGULATION OF NA,K ATPASE BY THE AH RECEPTORMary Walker; Fiscal Year: 2004..in decreased birth weights, neurological deficits, thyroid hormone alterations, lung auscultation, and hyperpigmentation. The mechanism by which TCDD mediates developmental toxicity has not been elucidated...
- NOVEL OLIGOPEPTIDES AS TOPICAL SKIN LIGHTENING AGENTSJAMES LEYDA; Fiscal Year: 2001..This natural agent provides a new approach to blocking the formation of melanin, the cause of hyperpigmentation. In both in vitro and in vivo models, the protein effectively inhibits the activity of tyrosinase, a marker ..
- NON-INVASIVE MEASUREMENT OF RPE LIPOFUSCINFrancois DeLori; Fiscal Year: 2005..correlate with rate or direction of greatest progression of subsequent atrophy, and whether discrete foci of hyperpigmentation consistently exhibit lipofuscin spectra...
- DIRECT, NONINVASIVE STUDY OF VENOUS FLOW AND THROMBOSISDONALD STRANDNESS; Fiscal Year: 1999Manifestations of the post-thrombotic syndrome, including pain, edema, hyperpigmentation, and ulceration, may develop in as many as two-thirds of patients after an episode of deep venous thrombosis (DVT)...
- READING CENTER FOR AMD PREVENTION TRIALStuart Fine; Fiscal Year: 2006..of AMD (for example, predominant drusen morphology drusen confluence, area of drusen involvement, focal hyperpigmentation, retinal pigment epithelial depigmentation, geographic atrophy...
- REACTIVE OXYGEN SPECIES AND ULTRAVIOLET LIGHT DAMAGEJohn Dietrich; Fiscal Year: 1990..2. The ability of CHX 100 and ROS scavengers to attenuate UVL- induced melanocyte hyperplasia and hyperpigmentation. The research is aimed at developing safe, effective topical drugs for the prevention of skin damage ..
- PULSED-LASER TREATMENT OF PIGMENTED LESIONS AND TATTOOSRobert Goldstein; Fiscal Year: 1990..variation of pulsewidth and wavelength, (4) perform a clinical dose/response study of epidermal and dermal hyperpigmentation using QSRL, and (5) produce and if possible optimize laser-induced leukotrichia (permanent hair bleaching)...
- Identify Waardenburg syndrome type 2 loci in manJEFFREY MILUNSKY; Fiscal Year: 2005..We will perform a high-density genome scan coupled with linkage disequilibrium analyses on 3 large multigenerational families and multiple smaller families with WS2 to identify candidate gene(s) with mutations causing WS2. ..
- Identify genes causing Kabuki SyndromeJEFFREY MILUNSKY; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- RETINAL PATHOPHYSIOLOGY OF INFANTS AND ADULTSDavid Birch; Fiscal Year: 2005..In the mouse models, cone measures will necessarily focus on the b-wave, using monochromatic stimuli, long-duration flashes, and flicker to optimize isolation of cone from rod responses. ..
- Dissecting the Molecular Basis of Ocular Albinism type 1Maria Vittoria Schiaffino; Fiscal Year: 2007..abstract_text> ..
- SPECIAL POPULATIONS NETWORK FOR CANCER CONTROLEdith Mitchell; Fiscal Year: 2003..abstract_text> ..
- BENEFITS OF TESTOSTERONE ON STRENGTH IN ELDERLY MENLaurence Katznelson; Fiscal Year: 2002..The goal of these studies will be to determine the efficacy and safety of testosterone administration and, additionally, a home-based exercise program on muscle function in older men with relative testosterone insufficiency. ..
- UV-induced collagen reduction: treating skin sclerodermaSewon Kang; Fiscal Year: 2005....
- PHENOLS/CATECHOLS IN OCCUPATIONAL/CONTACT VITILIGO SKINRaymond Boissy; Fiscal Year: 2002....
- 2004 National Vitiligo Foundation Scientific ConferenceRaymond Boissy; Fiscal Year: 2004..In addition, mini-symposiums will be organized for each of the sessions. ..
- Bilirubin and Photobilirubin: Metabolism & ExretionAntony McDonagh; Fiscal Year: 2005..The work will lead to safer more effective treatment of familial hyperbilirubinemia and jaundice in the newborn. ..
- CLINICAL TRANSLATIONAL RESEARCH IN DERMATOLOGYSewon Kang; Fiscal Year: 2004..abstract_text> ..
- ON THE ROLE OF THE HPS GENE PRODUCT IN MELANOCYTESRaymond Boissy; Fiscal Year: 2002..These studies will contribute to our knowledge of cellular trafficking in general and the pathophysiology of HPS in specific. ..
- Melanoma ChemopreventionRobert Dellavalle; Fiscal Year: 2006..His current career goals are completing a Masters of Science in Public Health and becoming an independent researcher in skin cancer prevention and control. ..