photosensitivity disorders

Summary

Summary: Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy.

Top Publications

  1. ncbi Kindler syndrome: extension of FERMT1 mutational spectrum and natural history
    Cristina Has
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    Hum Mutat 32:1204-12. 2011
  2. ncbi A review of UVA-mediated photosensitivity disorders
    E Smith
    Cardiff and Vale University Health Board, Heath Park, Cardiff, United Kingdom CF14 4XN
    Photochem Photobiol Sci 11:199-206. 2012
  3. ncbi Kindler surprise: mutations in a novel actin-associated protein cause Kindler syndrome
    Sharon J White
    Epithelial Genetics Group, Human Genetics Unit, University of Dundee, Ninewells Medical School, UK
    J Dermatol Sci 38:169-75. 2005
  4. pmc Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification
    Yinghong He
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Freiburg, Germany
    Am J Pathol 178:975-82. 2011
  5. ncbi Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes
    Haiyan Qu
    Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    Am J Pathol 180:1581-92. 2012
  6. pmc KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR)
    Jia Fei
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 287:35118-26. 2012
  7. ncbi Kindler syndrome: a focal adhesion genodermatosis
    J E Lai-Cheong
    Genetic Skin Disease Group, St John s Institute of Dermatology, King s College London, Guy s Campus, London SE1 9RT, UK
    Br J Dermatol 160:233-42. 2009
  8. ncbi Kindler syndrome: report of three cases in a family and a brief review
    Ameneh Yazdanfar
    Department of Dermatology, Hamedan University of Medical Sciences, Hamedan, Iran
    Int J Dermatol 48:145-9. 2009
  9. ncbi Mild clinical phenotype of Kindler syndrome associated with late diagnosis and skin cancer
    C Has
    Department of Dermatology, University Medical Centre Freiburg, Freiburg, Germany
    Dermatology 221:309-12. 2010
  10. ncbi Variable effects of beta-carotene therapy in a child with erythropoietic protoporphyria
    Ramin Alemzadeh
    Department of Pediatrics, University of Tennessee Medical Center, Knoxville, Tennessee, USA
    Eur J Pediatr 163:547-9. 2004

Detail Information

Publications246 found, 100 shown here

  1. ncbi Kindler syndrome: extension of FERMT1 mutational spectrum and natural history
    Cristina Has
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
    Hum Mutat 32:1204-12. 2011
    ..Environmental factors and yet unidentified modifiers may play a role. Better understanding of the molecular pathogenesis of KS should enable the development of prevention strategies for disease complications...
  2. ncbi A review of UVA-mediated photosensitivity disorders
    E Smith
    Cardiff and Vale University Health Board, Heath Park, Cardiff, United Kingdom CF14 4XN
    Photochem Photobiol Sci 11:199-206. 2012
    ..As such, clinical details, including treatments, are brief and succinct. Recent advances in understanding the pathogenesis of these conditions is highlighted...
  3. ncbi Kindler surprise: mutations in a novel actin-associated protein cause Kindler syndrome
    Sharon J White
    Epithelial Genetics Group, Human Genetics Unit, University of Dundee, Ninewells Medical School, UK
    J Dermatol Sci 38:169-75. 2005
    ..Kindler syndrome is therefore the first skin fragility syndrome due to disruption of the actin-extracellular matrix system...
  4. pmc Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification
    Yinghong He
    Department of Dermatology, University Medical Center Freiburg, Freiburg, Freiburg, Germany
    Am J Pathol 178:975-82. 2011
    ..This first example of environmental regulation of kindlin expression has implications for phenotype modulation in Kindler syndrome, a skin disorder caused by kindlin-1 deficiency...
  5. ncbi Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytes
    Haiyan Qu
    Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    Am J Pathol 180:1581-92. 2012
    ..Moreover, the constellation of molecular defects associated with the loss of kindlin-1 may explain the higher incidence of skin cancer observed in patients affected with this disorder...
  6. pmc KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR)
    Jia Fei
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 287:35118-26. 2012
    ..Together, our data not only reveal that KIAA1530 is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome...
  7. ncbi Kindler syndrome: a focal adhesion genodermatosis
    J E Lai-Cheong
    Genetic Skin Disease Group, St John s Institute of Dermatology, King s College London, Guy s Campus, London SE1 9RT, UK
    Br J Dermatol 160:233-42. 2009
    ..In this report, we review the clinical, cellular and molecular pathology of Kindler syndrome and discuss the role of fermitin family homologue 1 in keratinocyte biology...
  8. ncbi Kindler syndrome: report of three cases in a family and a brief review
    Ameneh Yazdanfar
    Department of Dermatology, Hamedan University of Medical Sciences, Hamedan, Iran
    Int J Dermatol 48:145-9. 2009
    ..Skin atrophy is more prominent on the extremities and the skin manifestations improve with age...
  9. ncbi Mild clinical phenotype of Kindler syndrome associated with late diagnosis and skin cancer
    C Has
    Department of Dermatology, University Medical Centre Freiburg, Freiburg, Germany
    Dermatology 221:309-12. 2010
    ..Taken together, we describe the natural course of KS, the morphological abnormalities occurring in the skin of older KS patients, we discuss the differential diagnosis and the association between KS and squamous cell carcinoma...
  10. ncbi Variable effects of beta-carotene therapy in a child with erythropoietic protoporphyria
    Ramin Alemzadeh
    Department of Pediatrics, University of Tennessee Medical Center, Knoxville, Tennessee, USA
    Eur J Pediatr 163:547-9. 2004
    ....
  11. pmc Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome
    J E Lai-Cheong
    Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London, London, UK
    J Invest Dermatol 128:2156-65. 2008
    ....
  12. ncbi Kindler syndrome
    G H S Ashton
    Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Skin Sciences, The Guy s, King s College and St Thomas Hospitals Medical School, London, UK
    Clin Exp Dermatol 29:116-21. 2004
    ....
  13. ncbi A review of UVB-mediated photosensitivity disorders
    F Kiss
    Aneurin Bevan Health Board, St Woolos Hospital, Stow Hill, Newport, UK
    Photochem Photobiol Sci 12:37-46. 2013
    ..The pathomechanisms for the acquired disorders are still largely undefined. Few therapeutic options are available so management of all these disorders still relies on rigorous photo-protection...
  14. ncbi Late-onset erythropoietic protoporphyria in association with haematological malignancy
    A Bharati
    Dermatology Department, Broadgreen Hospital, and Department of Medical Biochemistry and Immunology, University Hospital of Wales, Cardiff, UK
    Clin Exp Dermatol 31:668-70. 2006
  15. pmc Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skin
    A L Krunic
    Dermatologic Surgery Unit, Duke University Medical Center, Durham, NC 27710, USA
    Br J Cancer 77:1275-9. 1998
    ..This antibody may also have great potential for the detection of the effects of chemopreventive agents in skin cancer...
  16. ncbi Photosensitivity and acute liver injury in myeloproliferative disorder secondary to late-onset protoporphyria caused by deletion of a ferrochelatase gene in hematopoietic cells
    Richard G Goodwin
    Department of Dermatology, University Hospital of Wales, Cardiff, United Kingdom
    Blood 107:60-2. 2006
    ....
  17. ncbi Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome
    Florence Jobard
    Centre National de Genotypage, Evry, France
    Hum Mol Genet 12:925-35. 2003
    ..Kindlerin might be involved in the bidirectional signaling between integrin molecules in the membrane and the cytoskeleton, and could be involved in cell adhesion processes via integrin signaling...
  18. ncbi Late presentation of erythropoietic protoporphyria: case report and genetic analysis of family members
    L Berroeta
    Photobiology Unit, Ninewells Hospital and Medical School, Dundee, UK
    Br J Dermatol 157:1030-1. 2007
    ..Here we describe a patient with EPP, in whom the presenting clinical symptom, night-time itch, did not appear until middle age and who had an asymptomatic sister with the same FECH genotype...
  19. ncbi Human protoporphyria: reduced cutaneous photosensitivity and lower erythrocyte porphyrin levels during pregnancy
    M B Poh Fitzpatrick
    Department of Dermatology, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
    J Am Acad Dermatol 36:40-3. 1997
    ..057). CONCLUSION: These observations suggest that a beneficial physiologic effect of pregnancy in patients with EPP may be a lower circulating erythrocyte protoporphyrin burden that leads to reduced photosensitivity...
  20. ncbi Erythropoietic protoporphyria in the U.K.: clinical features and effect on quality of life
    S A Holme
    Department of Dermatology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Br J Dermatol 155:574-81. 2006
    ..Neither its full clinical spectrum nor its impact on quality of life (QoL) has been investigated in a large cohort of patients...
  21. ncbi A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo
    T P Millard
    Department of Photobiology, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
    Br J Dermatol 145:229-36. 2001
    ....
  22. ncbi Biochemical and molecular diagnosis of erythropoietic protoporphyria in an Ashkenazi Jewish family
    X Schneider-Yin
    Zentrallabor, Stadtspital Triemli, Birmensdorferstrasse 497, CH 8063, Zurich, Switzerland
    J Inherit Metab Dis 31:S363-7. 2008
    ..In addition, the frequency of IVS3-48c in the Ashkenazi Jewish population was estimated at 8%, which is similar to that in the European populations...
  23. ncbi Erythropoiesis and iron metabolism in dominant erythropoietic protoporphyria
    S Alexander Holme
    Department of Dermatology, University Hospital of Wales and School of Medicine, Cardiff University, Cardiff, United Kingdom
    Blood 110:4108-10. 2007
    ..This response may in part be mediated by protoporphyrin, but we found no correlation between erythrocyte protoporphyrin and Hb, sFn, total iron-binding capacity, or transferrin saturation...
  24. ncbi New insights into the pathogenesis of erythropoietic protoporphyria and their impact on patient care
    X Schneider Yin
    Zentrallabor, Stadtspital Triemli, , Switzerland
    Eur J Pediatr 159:719-25. 2000
    ..CONCLUSION: While covering the important clinical aspect of erythropoietic protoporphyria, this article emphasises the latest achievements in the molecular genetics of the disorder...
  25. ncbi Photosensitivity disorders: cause, effect and management
    Thomas P Millard
    Department of Photobiology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Am J Clin Dermatol 3:239-46. 2002
    ..Predominantly non-photosensitive dermatoses may also be exacerbated or precipitated by UVR; exposure to UVR should be reduced and sunscreens should be advocated, along with appropriate treatment of the underlying disease...
  26. ncbi Vascular changes in erythropoietic protoporphyria: histopathologic and immunohistochemical study
    K Timonen
    Department of Dermatology, Divisions of Endocrinology and Nephrology, University Hospital of Helsinki, Finland
    J Am Acad Dermatol 43:489-97. 2000
    ..Amorphous deposits distinguish EPP from variegate porphyria and porphyria cutanea tarda; a histopathologic examination may be a helpful tool in differentiating porphyric and nonporphyric photosensitivity...
  27. ncbi Recurrent painful hand crisis in a four-year-old girl, revealing an erythropoietic protoporphyria
    A L Labrousse
    Service de Dermatologie, , , 51092 Reims, France
    Eur J Dermatol 8:515-6. 1998
    ..The present case illustrates the effectiveness of beta-carotene associated with canthaxanthin in erythropoietic protoporphyria...
  28. ncbi [Photoprotection: effects and side effects]
    M Leverkus
    Universitätshautklinik Würzburg, Wurzburg
    Gesundheitswesen 66:S43-6. 2004
    ..The current recommendations for photoprotection for the general public are outlined...
  29. ncbi [Actinic keratoses]
    P Babilas
    Klinik und Poliklinik fur Dermatologie, Klinikum der Universitat Regensburg
    Hautarzt 54:551-60; quiz 561-2. 2003
    ..In the following review recent aspects of pathogenesis and therapy of actinic keratoses are discussed...
  30. ncbi ALA/PDT in the treatment of actinic keratosis: spot versus confluent therapy
    Mitchel Goldman
    Division of Dermatology, University of California San Diego, USA
    J Cosmet Laser Ther 5:107-10. 2003
    ..g. cryosurgery, curettage) and chemotherapeutics (e.g. topical 5-fluorouracil). The recent advances in photodynamic therapy (PDT) with 20% aminolevulinic acid (ALA) offer a novel, safe, and effective approach to AK therapy...
  31. pmc Osteopontin expression in normal skin and non-melanoma skin tumors
    Pi Ling Chang
    Department of Nutrition Sciences, 311 Susan Mott Webb Nutrition Sciences Building, 1675 University Boulevard, University of Alabama at Birmingham, Birmingham, Alabama 35295 3360, USA
    J Histochem Cytochem 56:57-66. 2008
    ..In conclusion, these data suggest that OPN is associated with keratinocyte differentiation and that it is expressed in AK and SCC, which have metastatic potential, but minimally expressed in solid BCC...
  32. ncbi Practical and experimental consideration of sun protection in dermatology
    William W Ting
    Department of Dermatology, University of Iowa College of Medicine, and University of Iowa Health Care, IA 52242, USA
    Int J Dermatol 42:505-13. 2003
    ..As these new photo-protective tools are being developed by scientists around the world, greater concerted effort is needed to engage public health officials and the media to promote sun protection awareness throughout the general public...
  33. ncbi Expression of the peripheral benzodiazepine receptor is decreased in skin cancers in comparison with normal skin
    J Morgan
    Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Br J Dermatol 151:846-56. 2004
    ..Increased or aberrant expression of PBR has been associated with aggressive behaviour in several tumour types including ovarian, colon and breast adenocarcinomas and glioblastoma...
  34. ncbi Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials
    Mark Lebwohl
    Department of Dermatology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Am Acad Dermatol 50:714-21. 2004
    ..The immune system plays a critical role in the development and pathogenesis of actinic keratosis (AK). Imiquimod has been shown to stimulate the cutaneous immune response and be effective for the treatment of nonmelanoma skin cancers...
  35. ncbi Does imiquimod histologically rejuvenate ultraviolet radiation-damaged skin?
    Kathleen Smith
    Dermatopathology, Quest Diagnostics, Tucker, Georgia 30084, USA
    Dermatol Surg 33:1419-28; discussion 1428-9. 2007
    ..Imiquimod (IMI) 5% is believed by some to result in an improved cosmetic appearance of chronically ultraviolet radiation (UV)-damaged skin...
  36. ncbi A randomized controlled clinical trial of topical photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratoses in transplant recipients
    G Dragieva
    Department of Dermatology, University Hospital of Zurich, 31 Gloriastr, 8091 Zurich, Switzerland
    Br J Dermatol 151:196-200. 2004
    ..Transplant recipients have an increased propensity to develop multiple actinic keratoses, which demonstrate an increased transformation rate into invasive squamous cell carcinoma...
  37. ncbi Workplace sun protection policies and employees' sun-related skin damage
    Torres Woolley
    Skin Cancer Research Group, North Queensland Centre for Cancer Research, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville QLD, Australia
    Am J Health Behav 32:201-8. 2008
    ..To investigate whether mandatory sun protection for outdoor workers in tropical regions is associated with reduced sun damage...
  38. ncbi [Solar urticaria]
    S Schauder
    Universitäts Hautklinik Göttingen, Goettingen
    Hautarzt 54:952-8. 2003
    ..A list is attached listing the dermatology departments with photodiagnostic units in Germany, Austria, and Switzerland...
  39. ncbi Split-face-study using two different light sources for topical PDT of actinic keratoses:non-inferiority of the LED system
    Philipp Babilas
    Department of Dermatology, University of Regensburg, Germany
    J Dtsch Dermatol Ges 6:25-32. 2008
    ..Light-emitting diodes (LED) are suitable light sources for topical PDT. To evaluate the efficacy, painfulness, patient satisfaction and cosmesis of LED-based PDT a prospective, randomized and controlled split-face study was performed...
  40. ncbi Topical photodynamic therapy in the treatment of actinic keratoses and Bowen's disease in transplant recipients
    Galya Dragieva
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Transplantation 77:115-21. 2004
    ..Topical photodynamic therapy (PDT) has been proven to be an effective treatment for AK and BD in immunocompetent patients, but no prospective trials in immunocompromised TR have been performed so far...
  41. ncbi Cutaneous horns of the eyelid: a clinicopathological study of 48 cases
    Enrique Mencía-Gutiérrez
    Department of Ophthalmology, 12 de Octubre Hospital, Complutense University, Cedro 23, E28250 Torrelodones, Madrid, Spain
    J Cutan Pathol 31:539-43. 2004
    ..This lesion may be associated with a benign, premalignant, or malignant lesion at the base, masking numerous conditions...
  42. ncbi Topical and light-based treatments for actinic keratoses
    Sirunya Silapunt
    DermSurgery Associates, Department of Medicine Dermatology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Semin Cutan Med Surg 22:162-70. 2003
    ..As the first stage of squamous cell carcinoma, actinic keratosis is worthy of prompt evaluation and active treatment...
  43. ncbi A randomized, double-blind, placebo-controlled study of the efficacy of tetracaine gel (Ametop) for pain relief during topical photodynamic therapy
    M V Holmes
    Photobiology Unit, University Department of Dermatology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Br J Dermatol 150:337-40. 2004
    ..Many patients find topical 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) painful. Local anaesthetics are not routinely used and their effect on PDT pain has not been examined...
  44. ncbi Nuclear morphometry and molecular biomarkers of actinic keratosis, sun-damaged, and nonexposed skin
    Philip M Carpenter
    Department of Pathology, Irvine Medical Center, University of California, Building 10, Route 40, Room 104, 101 The City Drive South, Orange, CA 92868, USA
    Cancer Epidemiol Biomarkers Prev 13:1996-2002. 2004
    ..Following these changes during a skin cancer chemopreventative trial can then help assess the efficacy of the agent and help determine where in the progression of neoplastic changes it exerts its biological effects...
  45. ncbi Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome
    M B Ericson
    Department of Dermatology, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Goteborg, Sweden
    Br J Dermatol 151:1204-12. 2004
    ..Recent studies in rodents have shown that a low fluence rate is preferable due to depletion of oxygen at high fluence rates. However, these results have not yet been verified in humans...
  46. ncbi Awareness, knowledge and attitudes to non-melanoma skin cancer and actinic keratosis among the general public
    Allan C Halpern
    Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Dermatol 44:107-11. 2005
    ..Objectives To establish the awareness, knowledge and attitudes of the general public to NMSC and provide an overview on their level of understanding and knowledge of preventative measures...
  47. ncbi Actinic keratoses, basal cell carcinoma, and squamous cell carcinoma: uncommon treatments
    Glenn G Russo
    Department of Dermatology, Tulane University Health Science Center, New Orleans, LA 70112, USA
    Clin Dermatol 23:581-6. 2005
    ..This article should not be interpreted as advocating the use of the methods discussed because there are obviously efficient well-established treatments for these lesions...
  48. ncbi A case of photocontact urticaria induced by photodynamic therapy with topical 5-aminolaevulinic acid
    Shohei Yokoyama
    Department of Dermatology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    J Dermatol 32:843-7. 2005
    ..These observations suggested an allergic pathogenesis for the wheal formation induced by PDT with topical ALA in this case. Photocontact urticaria should be considered as a possible adverse effect in ALA-based PDT...
  49. ncbi Skin cancer screening on a fishing island and in an inland agricultural area of Japan
    Saburo Anzai
    Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan
    J Dermatol 32:875-82. 2005
    ..Although people engaged in outdoor occupations are thought to be more prone to skin cancer and precancerous skin lesions, our results suggested different potentials for AK in people engaged in different outdoor occupations...
  50. ncbi [Reader's letter concerning K. Kreutzer, B.Bonnekoh, I. Franke, H. Gollnick. Photodynamic therapy with methylaminooxopentanoate (Metvix) and a broad band light source (Photdyn 501): practical experiences in problem patients with actinic keratoses and basa
    H Breuninger
    J Dtsch Dermatol Ges 3:397. 2005
  51. ncbi Treating actinic keratoses with imiquimod
    Anthony Dixon
    Skin Alert Skin Cancer Clinics and Skincanceronly, Belmont, Victoria, Australia
    Aust Fam Physician 36:341-2. 2007
    ..Lesions have generally resolved with cryotherapy but he finds the treatment very uncomfortable and can only tolerate a small number of lesions being treated on each visit. He develops lesions faster than lesions are treated...
  52. ncbi [Modern treatment modalities in actinic keratoses of the skin]
    A Hauschild
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Dtsch Med Wochenschr 131:447-52. 2006
    ..This overview will report on the actual treatment opportunities and a careful consideration in the year 2006...
  53. ncbi [Photodynamic therapy in dermatology]
    Yolanda Gilaberte
    Seccion de Dermatologia, Hospital San Jorge, Huesca, Spain
    Actas Dermosifiliogr 97:83-102. 2006
    ..We will also discuss its promising cosmetic application in the treatment of photoaging. We will complete the review with photodiagnosis and the different non-invasive ways to monitor the effectiveness of PDT...
  54. ncbi Topical diclofenac in the treatment of actinic keratoses
    Hans F Merk
    Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen, Aachen, Germany
    Int J Dermatol 46:12-8. 2007
  55. ncbi Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005
    Lasse R Braathen
    Dermatological University Clinic, Bern, Switzerland
    J Am Acad Dermatol 56:125-43. 2007
    ..PDT may also be a means of preventing certain nonmelanoma skin cancers in immunosuppressed patients...
  56. ncbi Intraindividual, right-left comparison of topical methyl aminolaevulinate-photodynamic therapy and cryotherapy in subjects with actinic keratoses: a multicentre, randomized controlled study
    C Morton
    Royal Cornwall Hospital, Truro TR1 3LJ, UK
    Br J Dermatol 155:1029-36. 2006
    ..Treatment should not only be effective, but also well tolerated and allow for good cosmesis on typical sun-exposed highly visible body sites...
  57. ncbi Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel
    Brian Berman
    Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Fam Pract 55:suppl 1-8. 2006
  58. ncbi Novel emerging sunscreen technologies
    Chanisada Tuchinda
    Department of Dermatology, Henry Ford Hospital, Detroit, MI 48303, USA
    Dermatol Clin 24:105-17. 2006
    ..With the advances in technologies, many new UV filters have been developed recently. These have improved efficacy and safety. This article reviews these new filters, along with regulatory issues in the United States...
  59. ncbi Sunscreen use in photodermatoses
    Vincent Deleo
    St Luke s Roosevelt and Beth Israel Medical Centers, New York, NY 10019, USA
    Dermatol Clin 24:27-33. 2006
    ..Until such time, clinicians should recommend agents with avobenzones, benzophenones, and the physical blockers titanium oxides. Two other agents, dihydroxyacetone and iron oxide, may also offer benefit in some of these patients...
  60. ncbi Photoprotection
    Stephan Lautenschlager
    Outpatient Clinic of Dermatology, Triemli Hospital, Zurich, Switzerland
    Lancet 370:528-37. 2007
    ..Nevertheless, sunscreens should not be abused in an attempt to increase time in the sun to a maximum. Controversies about safety of sunscreens and clinical recommendations are discussed...
  61. ncbi Topical photodynamic therapy of actinic keratosis in renal transplant recipients
    S Piaserico
    Clinica Dermatologica, Azienda Ospedale Università di Padova, Istituto Oncologico Veneto, Padova, Italy
    Transplant Proc 39:1847-50. 2007
    ..Topical PDT could represent a useful therapeutic alternative for AKs in OTRs because large lesions can be treated with excellent cosmetic outcome...
  62. ncbi [Therapeutic modalities and economic assessment in the treatment of superficial basal cell carcinomas and multiple actinic keratoses by French dermatologists]
    P Bernard
    Service de Dermatologie, Hopital Robert Debre, Reims
    Ann Dermatol Venereol 134:527-33. 2007
    ..The aim of the present study was to describe the therapeutic modalities for AK and sBCC adopted by French dermatologists and to determine the direct annual medical costs...
  63. ncbi The diagnostic concordance of actinic keratosis and squamous cell carcinoma
    Daniel A Davis
    Department of Dermatology, University of Arkansas for Medical Sciences, Central Arkansas Healthcare System, Little Rock, AR 72205 7199, USA
    J Cutan Pathol 32:546-51. 2005
    ..Davis DA, Donahue JP, Bost JE, Horn TD. The diagnostic concordance of actinic keratosis and squamous cell carcinoma...
  64. ncbi [Epidemiology of chronic UV-damage]
    Thomas L Diepgen
    Abt Klinische Sozialmedizin mit Schwerpunkt Berufs und Umweltdermatologie des Universitätsklinikums Heidelberg, Germany
    J Dtsch Dermatol Ges 3:S32-5. 2005
    ..Since the percentage of older people is increasing in Germany the therapeutic importance of UV-damage and its relevance for preventive medicine will be of increasing importance in the next years...
  65. ncbi [Sunprotection: possibilities and limitations]
    Peter Elsner
    Hautklinik, Universitatsklinikum Jena, Germany
    J Dtsch Dermatol Ges 3:S40-4. 2005
    ..Until these developments come to practice reasonable sun protection according to the skin complexion is of primary importance...
  66. ncbi Actinic granuloma
    Jennifer A Stein
    New York University Department of Dermatology, USA
    Dermatol Online J 13:19. 2007
    ..These findings were consistent with a diagnosis of actinic granuloma, which is an uncommon, idiopathic disease that is characterized by granuloma annulare-like plaques on sun-exposed areas...
  67. ncbi Vehicle-controlled, randomized, double-blind study to assess safety and efficacy of imiquimod 5% cream applied once daily 3 days per week in one or two courses of treatment of actinic keratoses on the head
    A Alomar
    Hospital de la Santa Creu i Sant Pau, Dermatology Service, Avda San Antonio María Claret, 167, Barcelona, Spain
    Br J Dermatol 157:133-41. 2007
    ..Imiquimod has been investigated as a safe and effective therapeutic option for the treatment of actinic keratosis (AK)...
  68. ncbi Efficacy of 3 different light doses in the treatment of actinic keratosis with 5-aminolevulinic acid photodynamic therapy: a randomized, observer-blinded, intrapatient, comparison study
    Sonja Radakovic-Fijan
    Division of Special and Environmental Dermatology, Medical University of Vienna, Vienna, Austria
    J Am Acad Dermatol 53:823-7. 2005
    ..As yet, however, data are lacking to define the optimal light dose for activation of ALA-induced protoporphyrin IX in AK...
  69. ncbi [Photodynamic therapy with methylaminooxopentanoate (Metvix) and a broad band light source (PhotoDyn 501): practical experiences in problem-patients with actinic keratoses and basal cell carcinomas]
    Katharina Kreutzer
    Klinik für Dermatologie und Venerologie, Otto von Guericke Universitat, Magdeburg
    J Dtsch Dermatol Ges 2:992-9. 2004
    ..Photodynamic therapy (PDT) offers a semi-conservative treatment option for selected indications...
  70. ncbi An overview of ultraviolet radiation, sunscreens, and photo-induced dermatoses
    N J Lowe
    Department of Dermatology, University of California School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
    Dermatol Clin 24:9-17. 2006
    ..This article reviews the protectiveness of sunscreens and assays that predict their levels of protection...
  71. ncbi Morphine gel 0.3% does not relieve pain during topical photodynamic therapy: a randomized, double-blind, placebo-controlled study
    Jette Skiveren
    Department of Dermatology D42, Copenhagen University Hospital, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen, Denmark
    Acta Derm Venereol 86:409-11. 2006
    ..95). There was no significant pain relief of topical morphine gel compared with placebo gel (p >0.23). This negative result suggests that opioid receptors may not be involved in the pain induced by photodynamic therapy...
  72. ncbi Cutaneous photoprotection
    John L M Hawk
    Arch Dermatol 139:527-30. 2003
  73. ncbi Laser-induced fluorescence spectroscopy for in vivo diagnosis of non-melanoma skin cancers
    Masoud Panjehpour
    Thompson Cancer Survival Center, Knoxville, Tennessee 37916, USA
    Lasers Surg Med 31:367-73. 2002
    ..The objective of this study was to determine whether in vivo laser-induced fluorescence spectroscopy alone at the visible excitation wavelength of 410 nm could be used to detect non-melanoma skin cancers...
  74. ncbi Skin DNA photodamage and its biological consequences
    Laurent Marrot
    L OREAL Advanced Research, Life Science Research, Investigative Toxicology Department, Genotoxicity Group, Aulnay sous Bois, France
    J Am Acad Dermatol 58:S139-48. 2008
    ..Besides the biological consequences of DNA photolesions, this article also deals with technologies used for their detection and shows how helpful such approaches can be to assess photoprotection provided by sunscreens...
  75. ncbi UV protection and skin cancer
    Reinhard Dummer
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Recent Results Cancer Res 160:7-12. 2002
    ..We conclude that there is substantial evidence that UV protection is able to reduce the risk of actinic keratosis, squamous cell carcinoma and probably also the risk of melanoma...
  76. ncbi Photoprotection of bacterial-derived melanin against ultraviolet A-induced cell death and its potential application as an active sunscreen
    J Geng
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
    J Eur Acad Dermatol Venereol 22:852-8. 2008
    ..The increase in the incidence of non-melanoma skin tumours, photoaging, and immunosuppression demand for more effective sunscreen on ultraviolet A (UVA) irradiation...
  77. ncbi Expression of CD95 (Fas) in sun-exposed human skin and cutaneous carcinomas
    Ewa Filipowicz
    Division of Surgical Pathology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0588, USA
    Cancer 94:814-9. 2002
    ....
  78. ncbi Sunscreens with high SPF values are not equivalent in protection from UVA induced polymorphous light eruption
    H Stege
    Clinical and Experimental Photodermatology, Department of Dermatology, University of Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Eur J Dermatol 12:IV-VI. 2002
  79. ncbi Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results
    Anny Fourtanier
    L Oreal Recherche, Clichy, France
    Photodermatol Photoimmunol Photomed 24:164-74. 2008
    ..Moreover UVA is implicated in the etiology of several photodermatoses. As a consequence, to provide adequate protection, sunscreens or skin care products for daily use protective products need UVA absorbers combined with UVB ones...
  80. ncbi The use of topical fluorouracil to treat actinic keratosis
    Perry Robins
    New York University, New York, USA
    Cutis 70:4-7. 2002
    ..The use of 0.5% fluorouracil cream may provide an effective, safe, and economical option to augment the available treatments of AK, which include liquid nitrogen cryotherapy and 5% and 1% fluorouracil creams...
  81. ncbi Skin cancer: a review and atlas for the medical provider
    R M Shelton
    The Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 68:243-52. 2001
    ..Unique clinical characteristics of skin malignancy are described in the text and illustrated with photographs of the most typical presentation(s) of each of the common skin cancers. Early recognition leads to cure in most cases...
  82. ncbi Is imiquimod effective and safe for actinic keratosis?
    J Kendall Walker
    Department of Family and Community Medicine, University of Missouri Columbia, USA
    J Fam Pract 52:184-5. 2003
    ..The 25 patients in the treatment group tolerated these adverse effects well. Despite these effects, imiquimod can be used as an alternative to traditional cryotherapy for the treatment of actinic keratosis among selected, motivated..
  83. ncbi Ultraviolet light downregulates CD95 ligand and TRAIL receptor expression facilitating actinic keratosis and squamous cell carcinoma formation
    F Bachmann
    Institute for Medical Microbiology, University of Basel, Basel, Switzerland
    J Invest Dermatol 117:59-66. 2001
    ..The high expression of CD95 ligand, TRAIL, and FLIP in squamous cell carcinoma may then contribute to the immune escape of the tumor, whereas the lack of expression of CD95 and TRAIL receptors prevents autolysis of the tumor...
  84. ncbi Randomized, double-blind, prospective study to compare topical 5-aminolaevulinic acid methylester with topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratosis
    F J Moloney
    City of Dublin Skin and Cancer Hospital, Dublin 2, Ireland
    Br J Dermatol 157:87-91. 2007
    ..While MAL is significantly more expensive than ALA, no studies have directly compared their efficacy in the treatment of extensive scalp AK...
  85. ncbi Update on sunscreens
    R Bissonnette
    Innovaderm Research, Montreal, QC, Canada
    Skin Therapy Lett 13:5-7. 2008
    ..This article will review some of the recent advances in photoprotection, including the development of sunscreen formulations offering higher and broader protection against solar radiation...
  86. ncbi Chronic actinic dermatitis in a patient with adult T-cell leukemia
    Yuka Adachi
    Department of Dermatology, Kansai Medical University, Osaka, Japan
    Photodermatol Photoimmunol Photomed 24:147-9. 2008
    ..In the present case, pseudolymphomatous changes occurred in association with adult T-cell leukemia. Southern blot analyses were useful for the correct diagnosis...
  87. ncbi Active oxygen intermediates in the degradation of hematoporphyrin derivative in tumor cells subjected to photodynamic therapy
    Lyudmila V Chekulayeva
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
    J Photochem Photobiol B 93:94-107. 2008
    ..It was found that HPD may destroy in tumor cells after cessation of photoirradiation and that this event is largely mediated by the presence of H2O2, a precursor of OH(.)...
  88. ncbi Influence of heating on the activity of xanthine oxidase in tumor cells subjected to the phototoxic action of hematoporphyrin derivative
    L Chekulayeva
    Tallinn University of Technology, Estonia
    Neoplasma 54:229-34. 2007
    ....
  89. ncbi The enhancement of riboflavin-mediated photo-oxidation of doxorubicin by histidine and urocanic acid
    A Ramu
    Texas Children s Cancer Center, Texas Children s Hospital, Baylor College of Medicine 6621 Fannin Street, MC 3 3320, Houston, TX 77030 2399, USA
    Cancer Chemother Pharmacol 47:338-46. 2001
    ..In the present study, we investigated the enhancement of this process by histidine and some other imidazole analogs...
  90. ncbi Photochemical characterization of water samples from Minnesota and Vermont sites with malformed frogs: potential influence of photosensitization by singlet molecular oxygen (1O(2)) and free radicals on aquatic toxicity
    P Bilski
    Laboratory of Pharmacology and Chemistry and Laboratory of Toxicology, ETP, NIEHS, Research Triangle Park, NC 27709, USA
    Aquat Toxicol 65:229-41. 2003
    ..The observation of 1O(2) emission directly from natural water may also provide new opportunities to investigate the involvement of 1O(2) in other complex environmental processes...
  91. ncbi Ergotism and photosensitization in swine produced by the combined ingestion of Claviceps purpurea sclerotia and Ammi majus seeds
    T A Lopez
    Departamento de Produccion Animal, Estacion Experimental Agropecuaria Balcarce, INTA, Buenos Aires, Argentina
    J Vet Diagn Invest 9:68-71. 1997
    ..Qualitative analysis demonstrated the presence of ergotamine, ergocristine, and ergonovine. These results indicate that clinical signs and lesions were caused by the ingestion of large quantities of these biologically active compounds...
  92. ncbi Recent advances in phototherapy
    J C Simon
    Department of Dermatology, University of Freiburg, Hauptstr 7, 79104 Freiburg, Germany
    Eur J Dermatol 10:642-5. 2000
    ..monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption...
  93. ncbi Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas
    S L Gibson
    Department of Biochemistry, University of Rochester School of Medicine and Dentistry, New York 14642
    Cancer Res 48:3360-6. 1988
    ..The data also suggest that photosensitivity-induced damage to these ion-activated plasma membrane ATPases could have deleterious effects on tumor cell survival...
  94. ncbi NADH photo-oxidation is enhanced by a partially purified lambda-crystallin fraction from rabbit lens
    Masayasu Bando
    Department of Ophthalmology, Tokai University School of Medicine, Isehara, Japan
    Mol Vis 13:1722-9. 2007
    ..The present investigation asks whether lambda-crystallin enhances NADH photo-oxidation by superoxide radicals produced via a photosensitization reaction of near-UV with NADH...
  95. ncbi Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells
    Lyudmila V Chekulayeva
    Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
    J Environ Pathol Toxicol Oncol 25:51-77. 2006
    ..and OH.) were also implicated in this process. However, further work is needed to clarify the significance of these peroxides in the antitumor effect of PDT with HPD...
  96. ncbi Effects of toluidine blue-mediated photodynamic therapy on periopathogens and periodontal biofilm: in vitro evaluation
    L Nastri
    Department of Stomatologic Orthodontic and Surgical Sciences, Second University of Naples, Naples, Italy
    Int J Immunopathol Pharmacol 23:1125-32. 2010
    ..In summary, photodynamic therapy has effectively shown its capabilities and, therefore, it can be considered a valid alternative approach to antimicrobial therapy of periodontitis...
  97. ncbi Acute effects of combined photodynamic therapy and hyperbaric oxygenation in lung cancer--a clinical pilot study
    F Tomaselli
    Department of Surgery, Division of Thoracic and Hyperbaric Surgery, University Medical School, Graz, Austria
    Lasers Surg Med 28:399-403. 2001
    ..The use of hyperbaric oxygenation (HBO) increases the amount of oxygen available for the process may thereby enhance the efficacy of PDT. We investigated the acute effects on tumor stenosis after combined PDT/HBO...
  98. ncbi Inactivation of food pathogen Bacillus cereus by photosensitization in vitro and on the surface of packaging material
    Z Luksiene
    Institute of Applied Research, Vilnius University, Vilnius, Lithuania
    J Appl Microbiol 107:2037-46. 2009
    ..The study was focused on the possibility to inactivate food pathogen Bacillus cereus by 5-aminolevulinic acid (ALA) - based photosensitization in vitro and after adhesion on the surface of packaging material...
  99. ncbi Induced and photoinduced DNA damage by quinolones: ciprofloxacin, ofloxacin and nalidixic acid determined by comet assay
    Georgina Sánchez
    Facultad de Farmacia, Universidad de Valparaiso, Valparaiso, Chile
    Photochem Photobiol 81:819-22. 2005
    ..The unirradiated drugs also exhibited genotoxicity significantly different from that of the negative control...
  100. ncbi Does hyperbaric oxygen enhance the effect of photodynamic therapy in patients with advanced esophageal carcinoma? A clinical pilot study
    A Maier
    Department of Thoracic and Hyperbaric Surgery, University Medical School, Graz, Austria
    Endoscopy 32:42-8. 2000
    ..In a clinical pilot study we assessed the use of photodynamic therapy (PDT) under hyperbaric oxygen (HBO), compared with PDT under normobaric conditions, in patients with advanced esophageal carcinoma...
  101. ncbi Photoallergic contact dermatitis is uncommon
    A Darvay
    Department of Environmental Dermatology, St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Br J Dermatol 145:597-601. 2001
    ..Despite the enormous increase in sunscreen use, allergic contact (AC) and photoallergic (PA) reactions to ultraviolet (UV) filters are considered rare...

Research Grants49

  1. The genetic basis of singlet oxygen-mediated signaling in eukaryotic cells
    Klaus Apel; Fiscal Year: 2013
    ....
  2. Photo-inactivation of Leishmania for safe and effective delivery of surrogate vac
    Kwang Poo Chang; Fiscal Year: 2013
    ..Completion of the proposed studies is thus expected to produce a final version of these carriers optimal for photodynamic immuno-therapy &-prophylaxis not only against leishmaniasis but also other infectious/non-infectious diseases. ..
  3. Delivery of Channel Rhodopsin for Optogenetic Control of Neurons in the Cochlea
    Daniel J Lee; Fiscal Year: 2013
    ..We propose that photosensitization of SGCs and insertion of an optical electrode for controlled stimulation of the inner ear may provide the basis for future CI technology based on light. ..
  4. Sphingolipids in Cell Death after Photodamage
    DUSKA M SEPAROVIC; Fiscal Year: 2012
    ..Thus, the proposal holds the promise of improving clinical PDT. ..
  5. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2007
    ..This proposal will be instrumental in the development of a novel PDT drug without long-term restrictions of patients' sun exposure. [unreadable] [unreadable]..
  6. CYSTEINE THERAPY FOR ERYTHROPOIETIC PROTOPORPHYRIA
    MICHELINE MATHEWS ROTH; Fiscal Year: 1993
    ..Given the success of this objective assessment, we will then study the effects of cysteine in 30 patients using a placebo-control cross-over design...
  7. Singlet Oxygen Signaling
    Krishna Niyogi; Fiscal Year: 2007
    ..This investigation will help illuminate studies of singlet oxygen biology in other organisms and provide fundamental knowledge about how eukaryotic cells sense and respond to singlet oxygen. ..
  8. CHARACTERIZATION OF NEW PHOTOSENSITIZING DYES
    David Kessel; Fiscal Year: 1992
    ..Exploration of these phenomena should facilitate the design of new dyes for PDT...
  9. Alternative Photosensitization Assay in the Mouse
    GEORGE DEGEORGE; Fiscal Year: 2001
    ..In addition, we believe that flow cytometry is underutilized in the toxicity-screening field and that this technology can be used to develop other commercially viable in vivo and vitro toxicity test at our company. ..
  10. PHOTODYNAMIC THERAPY OF MAMMARY TUMORS
    Russell Hilf; Fiscal Year: 1999
    ..Results from these experiments will provide insight into discrete actions of delta-ALA- induced photosensitization and will form the basis for design of more effective PDT regimens for clinical use. ..
  11. MBRS SCORE AT NEW MEXICO HIGHLANDS UNIVERSITY
    CHERYLE HORNE; Fiscal Year: 2003
    ..Overall, the proposed MBRS SCORE program is expected to enhance significantly the biomedical research competitiveness and capabilities of NMHU faculty...
  12. SINGLET OXYGEN AND LUNG PATHOGENESIS
    WALTER EISENBERG; Fiscal Year: 1990
    ..The overall goal of the research is to determine if there is a link between atmospherically generated O2- and some of the adverse health effects attributed to air pollution...
  13. PHOTOSENSTIZATION MECHANISMS IN HYPOXIC MEDIA
    ROBERT REDMOND; Fiscal Year: 2003
    ..The ability of a PIRG to modulate between oxygen-dependent and independent photosensitization mechanisms in direct response to oxygen levels will be investigated. ..
  14. LIPOPHILIC PROBES FOR TUMOR CELL SURFACES
    Fritz Sieber; Fiscal Year: 1990
    ....
  15. SYMPOSIUM ON PHOTODYNAMIC THERAPY
    David Kessel; Fiscal Year: 1990
    ..The other talks will be scheduled so as to provide ample discussion time. Recordings of all discussion will be made available for participants and others...
  16. Endogenous photosensitizers in skin carcinogenesis
    ELAINE JACOBSON; Fiscal Year: 2009
    ..This study will validate endogenous structural skin components as novel molecular Itargets for chemoprevention in skin photocarcinogenesis and photoaging and lead to a new class of Iphotoprotective agents. ..
  17. PHTHALOCYANINE PHOTOSENSITIZATION CYTOTOXIC MECHANISMS
    NANCY OLEINICK; Fiscal Year: 1990
    ....
  18. Photosensitization of Oral Bacteria
    NIKOLAOS SOUKOS; Fiscal Year: 2004
    ..In the same biofilm models the photodynamic effects of the PS will be established and PW-enhanced photosensitization of periodontopathogens by the PS will be evaluated. ..
  19. Photothermal Sensitization of Biological Systems
    Michael Rodgers; Fiscal Year: 2003
    ..In addition the team will investigate the propagation of thermal shock waves in biological materials. ..
  20. ULTRAVIOLET LIGHT INDUCED PHENOMENA IN BIOMEMBRANES
    IRENE KOCHEVAR; Fiscal Year: 2006
    ..Human keratinocytes and fibroblasts will be supplemented with 7-DHC, and UVA-induced production of PGE2 and IL-lcc will measured. ..
  21. MECHANISMS FOR CHRONIC UVR-INDUCED DAMAGE TO SKIN
    IRENE KOCHEVAR; Fiscal Year: 2003
    ..Elastase inhibitors will also be employed in vivo. In vitro experiments using human dermal fibroblasts grown in contracted collagen gels or skin equivalents will be used to define mechanisms for the phenomena observed in vivo. ..
  22. Chk2 as a target for regulating senescence in skin neoplasia
    Arianna Kim; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. DNA Damage and Neurodegeneration in Cockayne Syndrome
    James Cleaver; Fiscal Year: 2009
    ..Successful conclusion of these studies will expand our knowledge of mechanisms of neurodegeneration and lay groundwork for development of therapeutic approaches for CS patients. ..
  24. THE FRAMINGHAM SCHOOL STUDY OF NEVI IN CHILDREN: SONIC II
    Allan Halpern; Fiscal Year: 2008
    ..And, they will permit education of clinicians about the changes that routinely occur in nevi in adolescence which, in turn, should lead to a reduction of the large number of unnecessary nevus excisions in this age group. ..
  25. Molecular pathogenesis of UVB-induced skin cancer
    David Bickers; Fiscal Year: 2008
    ..Our animal models offer an innovative approach for assessing the molecular pathogenesis of UVB-induced SCCs and BCCs and could help create novel approaches to the prevention/treatment of human NMSCs. ..
  26. Photoreceptor Cell Vulnerability and Glutathione Status
    Barry S Winkler; Fiscal Year: 2010
    ..These outcomes should help in the design of therapeutic treatments for photoreceptor degenerations that are linked to an inadequate antioxidative defense mechanism. ..
  27. ENHANCEMENT OF PDT USING BIOLOGICAL RESPONSE MODIFIERS
    David A Bellnier; Fiscal Year: 2010
    ....
  28. Osteopontin and microenvironment of initiated cells
    Pi Ling Chang; Fiscal Year: 2010
    ..These proposed in vivo and in vitro studies will shed light on the molecular mechanism(s) by which a matricellular protein enhances the survival of transforming cells during early tumor promotion. ..
  29. Control of Eye Melanoma Metastsis
    Hans E Grossniklaus; Fiscal Year: 2010
    ..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
  30. Efficacy of Web-based Training in Skin Cancer Triage
    Martin Weinstock; Fiscal Year: 2007
    ..If this course is found to be efficacious, it will be made freely available on the web, and we will plan efforts to encourage its broad dissemination. [unreadable] [unreadable]..
  31. SKIN SELF EXAMINATION FOR EARLY DETECTION OF MELANOMA
    Martin Weinstock; Fiscal Year: 2002
    ..The knowledge and experiment thus gained will aid the continuing efforts to encourage SSE and reduce melanoma mortality. ..
  32. 2nd International Cervical Cancer Conference
    Michele Follen; Fiscal Year: 2002
    ..Each session chair and speaker has been chosen based on his/her publications, funding and national reputation. ..
  33. Control of Eye Melanoma Metastasis
    Hans Grossniklaus; Fiscal Year: 2003
    ..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
  34. SUBMACULAR SURGERY TRIALS PATHOLOGY CENTER
    Hans Grossniklaus; Fiscal Year: 2003
    ..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
  35. Dermatomyositis Skin Disease Severity Measure Validation
    JOSPEH JORIZZO; Fiscal Year: 2003
    ..abstract_text> ..
  36. Colorectal Screening Capacity Building Conference
    David Alberts; Fiscal Year: 2003
    ..Continued capacity building and future collaboration will also be woven into this conference to serve as a stone to build upon in the future. ..
  37. METABOLIC AND HOMEOSTATIC MECHANISMS IN RETINA AND RPE
    Barry Winkler; Fiscal Year: 2003
    ..g., diamox) which have been reported to decrease retinal edema. A long-term goal of the second project is to understand better the nature of the interactions between the retina and RPE and factors regulating retinal detachment. ..
  38. Role of Osteopontin in Tumor Promotion
    Pi Ling Chang; Fiscal Year: 2005
    ..Together, these studies will provide a better understanding of the role of OPN in tumor promotion and may contribute to the design of a mechanism-based strategy for cancer prevention. ..
  39. The XP Variant: A Human Mutator Gene for UV Damage
    James Cleaver; Fiscal Year: 2005
    ..We will express hRad3O on the keratin 14 promoter for over-expression in the skin, and make targeted knockout of mRad3O in vivo to identify roles for hRad3O in promoting and preventing carcinogenesis. ..
  40. ENZYME DEFECTS IN DISORDERS OF PROTOPORPHYRIN METABOLISM
    Joseph Bloomer; Fiscal Year: 2005
    ..The proposal thus is designed to define a critical relationship between FECH gene expression and phenotype in EPP which will lead to better genetic counseling and therapy. ..
  41. Basal Cell Carcinoma:Molecular Pathogenesis & Prevention
    David Bickers; Fiscal Year: 2006
    ..It is likely that novel anti-carcinogenic agents potentially suitable for testing in the human population could be identified as a result of the studies in this proposal. ..
  42. Cell cycle regulatory proteins in UVB-skin carcinogenes
    Arianna Kim; Fiscal Year: 2007
    ..In addition, our studies could provide a rationale to develop new therapeutic tools targeted towards the protein degradation machinery. ..
  43. MECHANISMS OF CUTANEOUS INJURY IN LUPUS ERYTHEMATOSUS
    Richard Sontheimer; Fiscal Year: 2001
    ....