Genomes and Genes
Summary: Abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues. It refers almost exclusively to skin photosensitivity, including sunburn, reactions due to repeated prolonged exposure in the absence of photosensitizing factors, and reactions requiring photosensitizing factors such as photosensitizing agents and certain diseases. With restricted reference to skin tissue, it does not include photosensitivity of the eye to light, as in photophobia or photosensitive epilepsy.
Publications246 found, 100 shown here
- Kindler syndrome: extension of FERMT1 mutational spectrum and natural historyCristina Has
Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany
Hum Mutat 32:1204-12. 2011..Environmental factors and yet unidentified modifiers may play a role. Better understanding of the molecular pathogenesis of KS should enable the development of prevention strategies for disease complications...
- A review of UVA-mediated photosensitivity disordersE Smith
Cardiff and Vale University Health Board, Heath Park, Cardiff, United Kingdom CF14 4XN
Photochem Photobiol Sci 11:199-206. 2012..As such, clinical details, including treatments, are brief and succinct. Recent advances in understanding the pathogenesis of these conditions is highlighted...
- Kindler surprise: mutations in a novel actin-associated protein cause Kindler syndromeSharon J White
Epithelial Genetics Group, Human Genetics Unit, University of Dundee, Ninewells Medical School, UK
J Dermatol Sci 38:169-75. 2005..Kindler syndrome is therefore the first skin fragility syndrome due to disruption of the actin-extracellular matrix system...
- Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modificationYinghong He
Department of Dermatology, University Medical Center Freiburg, Freiburg, Freiburg, Germany
Am J Pathol 178:975-82. 2011..This first example of environmental regulation of kindlin expression has implications for phenotype modulation in Kindler syndrome, a skin disorder caused by kindlin-1 deficiency...
- Partial loss of epithelial phenotype in kindlin-1-deficient keratinocytesHaiyan Qu
Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
Am J Pathol 180:1581-92. 2012..Moreover, the constellation of molecular defects associated with the loss of kindlin-1 may explain the higher incidence of skin cancer observed in patients affected with this disorder...
- KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR)Jia Fei
Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 287:35118-26. 2012..Together, our data not only reveal that KIAA1530 is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome...
- Kindler syndrome: a focal adhesion genodermatosisJ E Lai-Cheong
Genetic Skin Disease Group, St John s Institute of Dermatology, King s College London, Guy s Campus, London SE1 9RT, UK
Br J Dermatol 160:233-42. 2009..In this report, we review the clinical, cellular and molecular pathology of Kindler syndrome and discuss the role of fermitin family homologue 1 in keratinocyte biology...
- Kindler syndrome: report of three cases in a family and a brief reviewAmeneh Yazdanfar
Department of Dermatology, Hamedan University of Medical Sciences, Hamedan, Iran
Int J Dermatol 48:145-9. 2009..Skin atrophy is more prominent on the extremities and the skin manifestations improve with age...
- Mild clinical phenotype of Kindler syndrome associated with late diagnosis and skin cancerC Has
Department of Dermatology, University Medical Centre Freiburg, Freiburg, Germany
Dermatology 221:309-12. 2010..Taken together, we describe the natural course of KS, the morphological abnormalities occurring in the skin of older KS patients, we discuss the differential diagnosis and the association between KS and squamous cell carcinoma...
- Variable effects of beta-carotene therapy in a child with erythropoietic protoporphyriaRamin Alemzadeh
Department of Pediatrics, University of Tennessee Medical Center, Knoxville, Tennessee, USA
Eur J Pediatr 163:547-9. 2004....
- Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndromeJ E Lai-Cheong
Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, King s College London, London, UK
J Invest Dermatol 128:2156-65. 2008....
- Kindler syndromeG H S Ashton
Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Skin Sciences, The Guy s, King s College and St Thomas Hospitals Medical School, London, UK
Clin Exp Dermatol 29:116-21. 2004....
- A review of UVB-mediated photosensitivity disordersF Kiss
Aneurin Bevan Health Board, St Woolos Hospital, Stow Hill, Newport, UK
Photochem Photobiol Sci 12:37-46. 2013..The pathomechanisms for the acquired disorders are still largely undefined. Few therapeutic options are available so management of all these disorders still relies on rigorous photo-protection...
- Late-onset erythropoietic protoporphyria in association with haematological malignancyA Bharati
Dermatology Department, Broadgreen Hospital, and Department of Medical Biochemistry and Immunology, University Hospital of Wales, Cardiff, UK
Clin Exp Dermatol 31:668-70. 2006
- Immunohistochemical staining for desmogleins 1 and 2 in keratinocytic neoplasms with squamous phenotype: actinic keratosis, keratoacanthoma and squamous cell carcinoma of the skinA L Krunic
Dermatologic Surgery Unit, Duke University Medical Center, Durham, NC 27710, USA
Br J Cancer 77:1275-9. 1998..This antibody may also have great potential for the detection of the effects of chemopreventive agents in skin cancer...
- Photosensitivity and acute liver injury in myeloproliferative disorder secondary to late-onset protoporphyria caused by deletion of a ferrochelatase gene in hematopoietic cellsRichard G Goodwin
Department of Dermatology, University Hospital of Wales, Cardiff, United Kingdom
Blood 107:60-2. 2006....
- Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndromeFlorence Jobard
Centre National de Genotypage, Evry, France
Hum Mol Genet 12:925-35. 2003..Kindlerin might be involved in the bidirectional signaling between integrin molecules in the membrane and the cytoskeleton, and could be involved in cell adhesion processes via integrin signaling...
- Late presentation of erythropoietic protoporphyria: case report and genetic analysis of family membersL Berroeta
Photobiology Unit, Ninewells Hospital and Medical School, Dundee, UK
Br J Dermatol 157:1030-1. 2007..Here we describe a patient with EPP, in whom the presenting clinical symptom, night-time itch, did not appear until middle age and who had an asymptomatic sister with the same FECH genotype...
- Human protoporphyria: reduced cutaneous photosensitivity and lower erythrocyte porphyrin levels during pregnancyM B Poh Fitzpatrick
Department of Dermatology, Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, New York, NY 10019, USA
J Am Acad Dermatol 36:40-3. 1997..057). CONCLUSION: These observations suggest that a beneficial physiologic effect of pregnancy in patients with EPP may be a lower circulating erythrocyte protoporphyrin burden that leads to reduced photosensitivity...
- Erythropoietic protoporphyria in the U.K.: clinical features and effect on quality of lifeS A Holme
Department of Dermatology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
Br J Dermatol 155:574-81. 2006..Neither its full clinical spectrum nor its impact on quality of life (QoL) has been investigated in a large cohort of patients...
- A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigoT P Millard
Department of Photobiology, St John s Institute of Dermatology, St Thomas Hospital, London SE1 7EH, UK
Br J Dermatol 145:229-36. 2001....
- Biochemical and molecular diagnosis of erythropoietic protoporphyria in an Ashkenazi Jewish familyX Schneider-Yin
Zentrallabor, Stadtspital Triemli, Birmensdorferstrasse 497, CH 8063, Zurich, Switzerland
J Inherit Metab Dis 31:S363-7. 2008..In addition, the frequency of IVS3-48c in the Ashkenazi Jewish population was estimated at 8%, which is similar to that in the European populations...
- Erythropoiesis and iron metabolism in dominant erythropoietic protoporphyriaS Alexander Holme
Department of Dermatology, University Hospital of Wales and School of Medicine, Cardiff University, Cardiff, United Kingdom
Blood 110:4108-10. 2007..This response may in part be mediated by protoporphyrin, but we found no correlation between erythrocyte protoporphyrin and Hb, sFn, total iron-binding capacity, or transferrin saturation...
- New insights into the pathogenesis of erythropoietic protoporphyria and their impact on patient careX Schneider Yin
Zentrallabor, Stadtspital Triemli, , Switzerland
Eur J Pediatr 159:719-25. 2000..CONCLUSION: While covering the important clinical aspect of erythropoietic protoporphyria, this article emphasises the latest achievements in the molecular genetics of the disorder...
- Photosensitivity disorders: cause, effect and managementThomas P Millard
Department of Photobiology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
Am J Clin Dermatol 3:239-46. 2002..Predominantly non-photosensitive dermatoses may also be exacerbated or precipitated by UVR; exposure to UVR should be reduced and sunscreens should be advocated, along with appropriate treatment of the underlying disease...
- Vascular changes in erythropoietic protoporphyria: histopathologic and immunohistochemical studyK Timonen
Department of Dermatology, Divisions of Endocrinology and Nephrology, University Hospital of Helsinki, Finland
J Am Acad Dermatol 43:489-97. 2000..Amorphous deposits distinguish EPP from variegate porphyria and porphyria cutanea tarda; a histopathologic examination may be a helpful tool in differentiating porphyric and nonporphyric photosensitivity...
- Recurrent painful hand crisis in a four-year-old girl, revealing an erythropoietic protoporphyriaA L Labrousse
Service de Dermatologie, , , 51092 Reims, France
Eur J Dermatol 8:515-6. 1998..The present case illustrates the effectiveness of beta-carotene associated with canthaxanthin in erythropoietic protoporphyria...
- [Photoprotection: effects and side effects]M Leverkus
Universitätshautklinik Würzburg, Wurzburg
Gesundheitswesen 66:S43-6. 2004..The current recommendations for photoprotection for the general public are outlined...
- [Actinic keratoses]P Babilas
Klinik und Poliklinik fur Dermatologie, Klinikum der Universitat Regensburg
Hautarzt 54:551-60; quiz 561-2. 2003..In the following review recent aspects of pathogenesis and therapy of actinic keratoses are discussed...
- ALA/PDT in the treatment of actinic keratosis: spot versus confluent therapyMitchel Goldman
Division of Dermatology, University of California San Diego, USA
J Cosmet Laser Ther 5:107-10. 2003..g. cryosurgery, curettage) and chemotherapeutics (e.g. topical 5-fluorouracil). The recent advances in photodynamic therapy (PDT) with 20% aminolevulinic acid (ALA) offer a novel, safe, and effective approach to AK therapy...
- Osteopontin expression in normal skin and non-melanoma skin tumorsPi Ling Chang
Department of Nutrition Sciences, 311 Susan Mott Webb Nutrition Sciences Building, 1675 University Boulevard, University of Alabama at Birmingham, Birmingham, Alabama 35295 3360, USA
J Histochem Cytochem 56:57-66. 2008..In conclusion, these data suggest that OPN is associated with keratinocyte differentiation and that it is expressed in AK and SCC, which have metastatic potential, but minimally expressed in solid BCC...
- Practical and experimental consideration of sun protection in dermatologyWilliam W Ting
Department of Dermatology, University of Iowa College of Medicine, and University of Iowa Health Care, IA 52242, USA
Int J Dermatol 42:505-13. 2003..As these new photo-protective tools are being developed by scientists around the world, greater concerted effort is needed to engage public health officials and the media to promote sun protection awareness throughout the general public...
- Expression of the peripheral benzodiazepine receptor is decreased in skin cancers in comparison with normal skinJ Morgan
Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Br J Dermatol 151:846-56. 2004..Increased or aberrant expression of PBR has been associated with aggressive behaviour in several tumour types including ovarian, colon and breast adenocarcinomas and glioblastoma...
- Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trialsMark Lebwohl
Department of Dermatology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Am Acad Dermatol 50:714-21. 2004..The immune system plays a critical role in the development and pathogenesis of actinic keratosis (AK). Imiquimod has been shown to stimulate the cutaneous immune response and be effective for the treatment of nonmelanoma skin cancers...
- Does imiquimod histologically rejuvenate ultraviolet radiation-damaged skin?Kathleen Smith
Dermatopathology, Quest Diagnostics, Tucker, Georgia 30084, USA
Dermatol Surg 33:1419-28; discussion 1428-9. 2007..Imiquimod (IMI) 5% is believed by some to result in an improved cosmetic appearance of chronically ultraviolet radiation (UV)-damaged skin...
- A randomized controlled clinical trial of topical photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratoses in transplant recipientsG Dragieva
Department of Dermatology, University Hospital of Zurich, 31 Gloriastr, 8091 Zurich, Switzerland
Br J Dermatol 151:196-200. 2004..Transplant recipients have an increased propensity to develop multiple actinic keratoses, which demonstrate an increased transformation rate into invasive squamous cell carcinoma...
- Workplace sun protection policies and employees' sun-related skin damageTorres Woolley
Skin Cancer Research Group, North Queensland Centre for Cancer Research, School of Public Health, Tropical Medicine and Rehabilitation Sciences, James Cook University, Townsville QLD, Australia
Am J Health Behav 32:201-8. 2008..To investigate whether mandatory sun protection for outdoor workers in tropical regions is associated with reduced sun damage...
- [Solar urticaria]S Schauder
Universitäts Hautklinik Göttingen, Goettingen
Hautarzt 54:952-8. 2003..A list is attached listing the dermatology departments with photodiagnostic units in Germany, Austria, and Switzerland...
- Split-face-study using two different light sources for topical PDT of actinic keratoses:non-inferiority of the LED systemPhilipp Babilas
Department of Dermatology, University of Regensburg, Germany
J Dtsch Dermatol Ges 6:25-32. 2008..Light-emitting diodes (LED) are suitable light sources for topical PDT. To evaluate the efficacy, painfulness, patient satisfaction and cosmesis of LED-based PDT a prospective, randomized and controlled split-face study was performed...
- Topical photodynamic therapy in the treatment of actinic keratoses and Bowen's disease in transplant recipientsGalya Dragieva
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Transplantation 77:115-21. 2004..Topical photodynamic therapy (PDT) has been proven to be an effective treatment for AK and BD in immunocompetent patients, but no prospective trials in immunocompromised TR have been performed so far...
- Cutaneous horns of the eyelid: a clinicopathological study of 48 casesEnrique Mencía-Gutiérrez
Department of Ophthalmology, 12 de Octubre Hospital, Complutense University, Cedro 23, E28250 Torrelodones, Madrid, Spain
J Cutan Pathol 31:539-43. 2004..This lesion may be associated with a benign, premalignant, or malignant lesion at the base, masking numerous conditions...
- Topical and light-based treatments for actinic keratosesSirunya Silapunt
DermSurgery Associates, Department of Medicine Dermatology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Semin Cutan Med Surg 22:162-70. 2003..As the first stage of squamous cell carcinoma, actinic keratosis is worthy of prompt evaluation and active treatment...
- A randomized, double-blind, placebo-controlled study of the efficacy of tetracaine gel (Ametop) for pain relief during topical photodynamic therapyM V Holmes
Photobiology Unit, University Department of Dermatology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
Br J Dermatol 150:337-40. 2004..Many patients find topical 5-aminolaevulinic acid (ALA) photodynamic therapy (PDT) painful. Local anaesthetics are not routinely used and their effect on PDT pain has not been examined...
- Nuclear morphometry and molecular biomarkers of actinic keratosis, sun-damaged, and nonexposed skinPhilip M Carpenter
Department of Pathology, Irvine Medical Center, University of California, Building 10, Route 40, Room 104, 101 The City Drive South, Orange, CA 92868, USA
Cancer Epidemiol Biomarkers Prev 13:1996-2002. 2004..Following these changes during a skin cancer chemopreventative trial can then help assess the efficacy of the agent and help determine where in the progression of neoplastic changes it exerts its biological effects...
- Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcomeM B Ericson
Department of Dermatology, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Goteborg, Sweden
Br J Dermatol 151:1204-12. 2004..Recent studies in rodents have shown that a low fluence rate is preferable due to depletion of oxygen at high fluence rates. However, these results have not yet been verified in humans...
- Awareness, knowledge and attitudes to non-melanoma skin cancer and actinic keratosis among the general publicAllan C Halpern
Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Int J Dermatol 44:107-11. 2005..Objectives To establish the awareness, knowledge and attitudes of the general public to NMSC and provide an overview on their level of understanding and knowledge of preventative measures...
- Actinic keratoses, basal cell carcinoma, and squamous cell carcinoma: uncommon treatmentsGlenn G Russo
Department of Dermatology, Tulane University Health Science Center, New Orleans, LA 70112, USA
Clin Dermatol 23:581-6. 2005..This article should not be interpreted as advocating the use of the methods discussed because there are obviously efficient well-established treatments for these lesions...
- A case of photocontact urticaria induced by photodynamic therapy with topical 5-aminolaevulinic acidShohei Yokoyama
Department of Dermatology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
J Dermatol 32:843-7. 2005..These observations suggested an allergic pathogenesis for the wheal formation induced by PDT with topical ALA in this case. Photocontact urticaria should be considered as a possible adverse effect in ALA-based PDT...
- Skin cancer screening on a fishing island and in an inland agricultural area of JapanSaburo Anzai
Department of Dermatology, Faculty of Medicine, Oita University, Oita, Japan
J Dermatol 32:875-82. 2005..Although people engaged in outdoor occupations are thought to be more prone to skin cancer and precancerous skin lesions, our results suggested different potentials for AK in people engaged in different outdoor occupations...
- [Reader's letter concerning K. Kreutzer, B.Bonnekoh, I. Franke, H. Gollnick. Photodynamic therapy with methylaminooxopentanoate (Metvix) and a broad band light source (Photdyn 501): practical experiences in problem patients with actinic keratoses and basaH Breuninger
J Dtsch Dermatol Ges 3:397. 2005
- Treating actinic keratoses with imiquimodAnthony Dixon
Skin Alert Skin Cancer Clinics and Skincanceronly, Belmont, Victoria, Australia
Aust Fam Physician 36:341-2. 2007..Lesions have generally resolved with cryotherapy but he finds the treatment very uncomfortable and can only tolerate a small number of lesions being treated on each visit. He develops lesions faster than lesions are treated...
- [Modern treatment modalities in actinic keratoses of the skin]A Hauschild
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
Dtsch Med Wochenschr 131:447-52. 2006..This overview will report on the actual treatment opportunities and a careful consideration in the year 2006...
- [Photodynamic therapy in dermatology]Yolanda Gilaberte
Seccion de Dermatologia, Hospital San Jorge, Huesca, Spain
Actas Dermosifiliogr 97:83-102. 2006..We will also discuss its promising cosmetic application in the treatment of photoaging. We will complete the review with photodiagnosis and the different non-invasive ways to monitor the effectiveness of PDT...
- Topical diclofenac in the treatment of actinic keratosesHans F Merk
Department of Dermatology and Allergology, Medical Faculty, RWTH Aachen, Aachen, Germany
Int J Dermatol 46:12-8. 2007
- Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005Lasse R Braathen
Dermatological University Clinic, Bern, Switzerland
J Am Acad Dermatol 56:125-43. 2007..PDT may also be a means of preventing certain nonmelanoma skin cancers in immunosuppressed patients...
- Intraindividual, right-left comparison of topical methyl aminolaevulinate-photodynamic therapy and cryotherapy in subjects with actinic keratoses: a multicentre, randomized controlled studyC Morton
Royal Cornwall Hospital, Truro TR1 3LJ, UK
Br J Dermatol 155:1029-36. 2006..Treatment should not only be effective, but also well tolerated and allow for good cosmesis on typical sun-exposed highly visible body sites...
- Actinic keratoses: sequelae and treatments. Recommendations from a consensus panelBrian Berman
Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida, USA
J Fam Pract 55:suppl 1-8. 2006
- Novel emerging sunscreen technologiesChanisada Tuchinda
Department of Dermatology, Henry Ford Hospital, Detroit, MI 48303, USA
Dermatol Clin 24:105-17. 2006..With the advances in technologies, many new UV filters have been developed recently. These have improved efficacy and safety. This article reviews these new filters, along with regulatory issues in the United States...
- Sunscreen use in photodermatosesVincent Deleo
St Luke s Roosevelt and Beth Israel Medical Centers, New York, NY 10019, USA
Dermatol Clin 24:27-33. 2006..Until such time, clinicians should recommend agents with avobenzones, benzophenones, and the physical blockers titanium oxides. Two other agents, dihydroxyacetone and iron oxide, may also offer benefit in some of these patients...
- PhotoprotectionStephan Lautenschlager
Outpatient Clinic of Dermatology, Triemli Hospital, Zurich, Switzerland
Lancet 370:528-37. 2007..Nevertheless, sunscreens should not be abused in an attempt to increase time in the sun to a maximum. Controversies about safety of sunscreens and clinical recommendations are discussed...
- Topical photodynamic therapy of actinic keratosis in renal transplant recipientsS Piaserico
Clinica Dermatologica, Azienda Ospedale Università di Padova, Istituto Oncologico Veneto, Padova, Italy
Transplant Proc 39:1847-50. 2007..Topical PDT could represent a useful therapeutic alternative for AKs in OTRs because large lesions can be treated with excellent cosmetic outcome...
- [Therapeutic modalities and economic assessment in the treatment of superficial basal cell carcinomas and multiple actinic keratoses by French dermatologists]P Bernard
Service de Dermatologie, Hopital Robert Debre, Reims
Ann Dermatol Venereol 134:527-33. 2007..The aim of the present study was to describe the therapeutic modalities for AK and sBCC adopted by French dermatologists and to determine the direct annual medical costs...
- The diagnostic concordance of actinic keratosis and squamous cell carcinomaDaniel A Davis
Department of Dermatology, University of Arkansas for Medical Sciences, Central Arkansas Healthcare System, Little Rock, AR 72205 7199, USA
J Cutan Pathol 32:546-51. 2005..Davis DA, Donahue JP, Bost JE, Horn TD. The diagnostic concordance of actinic keratosis and squamous cell carcinoma...
- [Epidemiology of chronic UV-damage]Thomas L Diepgen
Abt Klinische Sozialmedizin mit Schwerpunkt Berufs und Umweltdermatologie des Universitätsklinikums Heidelberg, Germany
J Dtsch Dermatol Ges 3:S32-5. 2005..Since the percentage of older people is increasing in Germany the therapeutic importance of UV-damage and its relevance for preventive medicine will be of increasing importance in the next years...
- [Sunprotection: possibilities and limitations]Peter Elsner
Hautklinik, Universitatsklinikum Jena, Germany
J Dtsch Dermatol Ges 3:S40-4. 2005..Until these developments come to practice reasonable sun protection according to the skin complexion is of primary importance...
- Actinic granulomaJennifer A Stein
New York University Department of Dermatology, USA
Dermatol Online J 13:19. 2007..These findings were consistent with a diagnosis of actinic granuloma, which is an uncommon, idiopathic disease that is characterized by granuloma annulare-like plaques on sun-exposed areas...
- Vehicle-controlled, randomized, double-blind study to assess safety and efficacy of imiquimod 5% cream applied once daily 3 days per week in one or two courses of treatment of actinic keratoses on the headA Alomar
Hospital de la Santa Creu i Sant Pau, Dermatology Service, Avda San Antonio María Claret, 167, Barcelona, Spain
Br J Dermatol 157:133-41. 2007..Imiquimod has been investigated as a safe and effective therapeutic option for the treatment of actinic keratosis (AK)...
- Efficacy of 3 different light doses in the treatment of actinic keratosis with 5-aminolevulinic acid photodynamic therapy: a randomized, observer-blinded, intrapatient, comparison studySonja Radakovic-Fijan
Division of Special and Environmental Dermatology, Medical University of Vienna, Vienna, Austria
J Am Acad Dermatol 53:823-7. 2005..As yet, however, data are lacking to define the optimal light dose for activation of ALA-induced protoporphyrin IX in AK...
- [Photodynamic therapy with methylaminooxopentanoate (Metvix) and a broad band light source (PhotoDyn 501): practical experiences in problem-patients with actinic keratoses and basal cell carcinomas]Katharina Kreutzer
Klinik für Dermatologie und Venerologie, Otto von Guericke Universitat, Magdeburg
J Dtsch Dermatol Ges 2:992-9. 2004..Photodynamic therapy (PDT) offers a semi-conservative treatment option for selected indications...
- An overview of ultraviolet radiation, sunscreens, and photo-induced dermatosesN J Lowe
Department of Dermatology, University of California School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA
Dermatol Clin 24:9-17. 2006..This article reviews the protectiveness of sunscreens and assays that predict their levels of protection...
- Morphine gel 0.3% does not relieve pain during topical photodynamic therapy: a randomized, double-blind, placebo-controlled studyJette Skiveren
Department of Dermatology D42, Copenhagen University Hospital, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen, Denmark
Acta Derm Venereol 86:409-11. 2006..95). There was no significant pain relief of topical morphine gel compared with placebo gel (p >0.23). This negative result suggests that opioid receptors may not be involved in the pain induced by photodynamic therapy...
- Cutaneous photoprotectionJohn L M Hawk
Arch Dermatol 139:527-30. 2003
- Laser-induced fluorescence spectroscopy for in vivo diagnosis of non-melanoma skin cancersMasoud Panjehpour
Thompson Cancer Survival Center, Knoxville, Tennessee 37916, USA
Lasers Surg Med 31:367-73. 2002..The objective of this study was to determine whether in vivo laser-induced fluorescence spectroscopy alone at the visible excitation wavelength of 410 nm could be used to detect non-melanoma skin cancers...
- Skin DNA photodamage and its biological consequencesLaurent Marrot
L OREAL Advanced Research, Life Science Research, Investigative Toxicology Department, Genotoxicity Group, Aulnay sous Bois, France
J Am Acad Dermatol 58:S139-48. 2008..Besides the biological consequences of DNA photolesions, this article also deals with technologies used for their detection and shows how helpful such approaches can be to assess photoprotection provided by sunscreens...
- UV protection and skin cancerReinhard Dummer
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
Recent Results Cancer Res 160:7-12. 2002..We conclude that there is substantial evidence that UV protection is able to reduce the risk of actinic keratosis, squamous cell carcinoma and probably also the risk of melanoma...
- Photoprotection of bacterial-derived melanin against ultraviolet A-induced cell death and its potential application as an active sunscreenJ Geng
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
J Eur Acad Dermatol Venereol 22:852-8. 2008..The increase in the incidence of non-melanoma skin tumours, photoaging, and immunosuppression demand for more effective sunscreen on ultraviolet A (UVA) irradiation...
- Expression of CD95 (Fas) in sun-exposed human skin and cutaneous carcinomasEwa Filipowicz
Division of Surgical Pathology, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0588, USA
Cancer 94:814-9. 2002....
- Sunscreens with high SPF values are not equivalent in protection from UVA induced polymorphous light eruptionH Stege
Clinical and Experimental Photodermatology, Department of Dermatology, University of Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
Eur J Dermatol 12:IV-VI. 2002
- Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study resultsAnny Fourtanier
L Oreal Recherche, Clichy, France
Photodermatol Photoimmunol Photomed 24:164-74. 2008..Moreover UVA is implicated in the etiology of several photodermatoses. As a consequence, to provide adequate protection, sunscreens or skin care products for daily use protective products need UVA absorbers combined with UVB ones...
- The use of topical fluorouracil to treat actinic keratosisPerry Robins
New York University, New York, USA
Cutis 70:4-7. 2002..The use of 0.5% fluorouracil cream may provide an effective, safe, and economical option to augment the available treatments of AK, which include liquid nitrogen cryotherapy and 5% and 1% fluorouracil creams...
- Skin cancer: a review and atlas for the medical providerR M Shelton
The Mount Sinai School of Medicine, New York, NY, USA
Mt Sinai J Med 68:243-52. 2001..Unique clinical characteristics of skin malignancy are described in the text and illustrated with photographs of the most typical presentation(s) of each of the common skin cancers. Early recognition leads to cure in most cases...
- Is imiquimod effective and safe for actinic keratosis?J Kendall Walker
Department of Family and Community Medicine, University of Missouri Columbia, USA
J Fam Pract 52:184-5. 2003..The 25 patients in the treatment group tolerated these adverse effects well. Despite these effects, imiquimod can be used as an alternative to traditional cryotherapy for the treatment of actinic keratosis among selected, motivated..
- Ultraviolet light downregulates CD95 ligand and TRAIL receptor expression facilitating actinic keratosis and squamous cell carcinoma formationF Bachmann
Institute for Medical Microbiology, University of Basel, Basel, Switzerland
J Invest Dermatol 117:59-66. 2001..The high expression of CD95 ligand, TRAIL, and FLIP in squamous cell carcinoma may then contribute to the immune escape of the tumor, whereas the lack of expression of CD95 and TRAIL receptors prevents autolysis of the tumor...
- Randomized, double-blind, prospective study to compare topical 5-aminolaevulinic acid methylester with topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratosisF J Moloney
City of Dublin Skin and Cancer Hospital, Dublin 2, Ireland
Br J Dermatol 157:87-91. 2007..While MAL is significantly more expensive than ALA, no studies have directly compared their efficacy in the treatment of extensive scalp AK...
- Update on sunscreensR Bissonnette
Innovaderm Research, Montreal, QC, Canada
Skin Therapy Lett 13:5-7. 2008..This article will review some of the recent advances in photoprotection, including the development of sunscreen formulations offering higher and broader protection against solar radiation...
- Chronic actinic dermatitis in a patient with adult T-cell leukemiaYuka Adachi
Department of Dermatology, Kansai Medical University, Osaka, Japan
Photodermatol Photoimmunol Photomed 24:147-9. 2008..In the present case, pseudolymphomatous changes occurred in association with adult T-cell leukemia. Southern blot analyses were useful for the correct diagnosis...
- Active oxygen intermediates in the degradation of hematoporphyrin derivative in tumor cells subjected to photodynamic therapyLyudmila V Chekulayeva
Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
J Photochem Photobiol B 93:94-107. 2008..It was found that HPD may destroy in tumor cells after cessation of photoirradiation and that this event is largely mediated by the presence of H2O2, a precursor of OH(.)...
- Influence of heating on the activity of xanthine oxidase in tumor cells subjected to the phototoxic action of hematoporphyrin derivativeL Chekulayeva
Tallinn University of Technology, Estonia
Neoplasma 54:229-34. 2007....
- The enhancement of riboflavin-mediated photo-oxidation of doxorubicin by histidine and urocanic acidA Ramu
Texas Children s Cancer Center, Texas Children s Hospital, Baylor College of Medicine 6621 Fannin Street, MC 3 3320, Houston, TX 77030 2399, USA
Cancer Chemother Pharmacol 47:338-46. 2001..In the present study, we investigated the enhancement of this process by histidine and some other imidazole analogs...
- Photochemical characterization of water samples from Minnesota and Vermont sites with malformed frogs: potential influence of photosensitization by singlet molecular oxygen (1O(2)) and free radicals on aquatic toxicityP Bilski
Laboratory of Pharmacology and Chemistry and Laboratory of Toxicology, ETP, NIEHS, Research Triangle Park, NC 27709, USA
Aquat Toxicol 65:229-41. 2003..The observation of 1O(2) emission directly from natural water may also provide new opportunities to investigate the involvement of 1O(2) in other complex environmental processes...
- Ergotism and photosensitization in swine produced by the combined ingestion of Claviceps purpurea sclerotia and Ammi majus seedsT A Lopez
Departamento de Produccion Animal, Estacion Experimental Agropecuaria Balcarce, INTA, Buenos Aires, Argentina
J Vet Diagn Invest 9:68-71. 1997..Qualitative analysis demonstrated the presence of ergotamine, ergocristine, and ergonovine. These results indicate that clinical signs and lesions were caused by the ingestion of large quantities of these biologically active compounds...
- Recent advances in phototherapyJ C Simon
Department of Dermatology, University of Freiburg, Hauptstr 7, 79104 Freiburg, Germany
Eur J Dermatol 10:642-5. 2000..monotherapy or combined with dithranol, oral retinoids or 8-MOP in psoriasis, atopic dermatitis (AD) or photosensitivity disorders such as polymorphic light eruption...
- Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomasS L Gibson
Department of Biochemistry, University of Rochester School of Medicine and Dentistry, New York 14642
Cancer Res 48:3360-6. 1988..The data also suggest that photosensitivity-induced damage to these ion-activated plasma membrane ATPases could have deleterious effects on tumor cell survival...
- NADH photo-oxidation is enhanced by a partially purified lambda-crystallin fraction from rabbit lensMasayasu Bando
Department of Ophthalmology, Tokai University School of Medicine, Isehara, Japan
Mol Vis 13:1722-9. 2007..The present investigation asks whether lambda-crystallin enhances NADH photo-oxidation by superoxide radicals produced via a photosensitization reaction of near-UV with NADH...
- Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cellsLyudmila V Chekulayeva
Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
J Environ Pathol Toxicol Oncol 25:51-77. 2006..and OH.) were also implicated in this process. However, further work is needed to clarify the significance of these peroxides in the antitumor effect of PDT with HPD...
- Effects of toluidine blue-mediated photodynamic therapy on periopathogens and periodontal biofilm: in vitro evaluationL Nastri
Department of Stomatologic Orthodontic and Surgical Sciences, Second University of Naples, Naples, Italy
Int J Immunopathol Pharmacol 23:1125-32. 2010..In summary, photodynamic therapy has effectively shown its capabilities and, therefore, it can be considered a valid alternative approach to antimicrobial therapy of periodontitis...
- Acute effects of combined photodynamic therapy and hyperbaric oxygenation in lung cancer--a clinical pilot studyF Tomaselli
Department of Surgery, Division of Thoracic and Hyperbaric Surgery, University Medical School, Graz, Austria
Lasers Surg Med 28:399-403. 2001..The use of hyperbaric oxygenation (HBO) increases the amount of oxygen available for the process may thereby enhance the efficacy of PDT. We investigated the acute effects on tumor stenosis after combined PDT/HBO...
- Inactivation of food pathogen Bacillus cereus by photosensitization in vitro and on the surface of packaging materialZ Luksiene
Institute of Applied Research, Vilnius University, Vilnius, Lithuania
J Appl Microbiol 107:2037-46. 2009..The study was focused on the possibility to inactivate food pathogen Bacillus cereus by 5-aminolevulinic acid (ALA) - based photosensitization in vitro and after adhesion on the surface of packaging material...
- Induced and photoinduced DNA damage by quinolones: ciprofloxacin, ofloxacin and nalidixic acid determined by comet assayGeorgina Sánchez
Facultad de Farmacia, Universidad de Valparaiso, Valparaiso, Chile
Photochem Photobiol 81:819-22. 2005..The unirradiated drugs also exhibited genotoxicity significantly different from that of the negative control...
- Does hyperbaric oxygen enhance the effect of photodynamic therapy in patients with advanced esophageal carcinoma? A clinical pilot studyA Maier
Department of Thoracic and Hyperbaric Surgery, University Medical School, Graz, Austria
Endoscopy 32:42-8. 2000..In a clinical pilot study we assessed the use of photodynamic therapy (PDT) under hyperbaric oxygen (HBO), compared with PDT under normobaric conditions, in patients with advanced esophageal carcinoma...
- Photoallergic contact dermatitis is uncommonA Darvay
Department of Environmental Dermatology, St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
Br J Dermatol 145:597-601. 2001..Despite the enormous increase in sunscreen use, allergic contact (AC) and photoallergic (PA) reactions to ultraviolet (UV) filters are considered rare...
- The genetic basis of singlet oxygen-mediated signaling in eukaryotic cellsKlaus Apel; Fiscal Year: 2013....
- Photo-inactivation of Leishmania for safe and effective delivery of surrogate vacKwang Poo Chang; Fiscal Year: 2013..Completion of the proposed studies is thus expected to produce a final version of these carriers optimal for photodynamic immuno-therapy &-prophylaxis not only against leishmaniasis but also other infectious/non-infectious diseases. ..
- Delivery of Channel Rhodopsin for Optogenetic Control of Neurons in the CochleaDaniel J Lee; Fiscal Year: 2013..We propose that photosensitization of SGCs and insertion of an optical electrode for controlled stimulation of the inner ear may provide the basis for future CI technology based on light. ..
- Sphingolipids in Cell Death after PhotodamageDUSKA M SEPAROVIC; Fiscal Year: 2012..Thus, the proposal holds the promise of improving clinical PDT. ..
- Photodynamic Therapy for the Treatment of Obstructive E*Todd Demmy; Fiscal Year: 2007..This proposal will be instrumental in the development of a novel PDT drug without long-term restrictions of patients' sun exposure. [unreadable] [unreadable]..
- CYSTEINE THERAPY FOR ERYTHROPOIETIC PROTOPORPHYRIAMICHELINE MATHEWS ROTH; Fiscal Year: 1993..Given the success of this objective assessment, we will then study the effects of cysteine in 30 patients using a placebo-control cross-over design...
- Singlet Oxygen SignalingKrishna Niyogi; Fiscal Year: 2007..This investigation will help illuminate studies of singlet oxygen biology in other organisms and provide fundamental knowledge about how eukaryotic cells sense and respond to singlet oxygen. ..
- CHARACTERIZATION OF NEW PHOTOSENSITIZING DYESDavid Kessel; Fiscal Year: 1992..Exploration of these phenomena should facilitate the design of new dyes for PDT...
- Alternative Photosensitization Assay in the MouseGEORGE DEGEORGE; Fiscal Year: 2001..In addition, we believe that flow cytometry is underutilized in the toxicity-screening field and that this technology can be used to develop other commercially viable in vivo and vitro toxicity test at our company. ..
- PHOTODYNAMIC THERAPY OF MAMMARY TUMORSRussell Hilf; Fiscal Year: 1999..Results from these experiments will provide insight into discrete actions of delta-ALA- induced photosensitization and will form the basis for design of more effective PDT regimens for clinical use. ..
- MBRS SCORE AT NEW MEXICO HIGHLANDS UNIVERSITYCHERYLE HORNE; Fiscal Year: 2003..Overall, the proposed MBRS SCORE program is expected to enhance significantly the biomedical research competitiveness and capabilities of NMHU faculty...
- SINGLET OXYGEN AND LUNG PATHOGENESISWALTER EISENBERG; Fiscal Year: 1990..The overall goal of the research is to determine if there is a link between atmospherically generated O2- and some of the adverse health effects attributed to air pollution...
- PHOTOSENSTIZATION MECHANISMS IN HYPOXIC MEDIAROBERT REDMOND; Fiscal Year: 2003..The ability of a PIRG to modulate between oxygen-dependent and independent photosensitization mechanisms in direct response to oxygen levels will be investigated. ..
- LIPOPHILIC PROBES FOR TUMOR CELL SURFACESFritz Sieber; Fiscal Year: 1990....
- SYMPOSIUM ON PHOTODYNAMIC THERAPYDavid Kessel; Fiscal Year: 1990..The other talks will be scheduled so as to provide ample discussion time. Recordings of all discussion will be made available for participants and others...
- Endogenous photosensitizers in skin carcinogenesisELAINE JACOBSON; Fiscal Year: 2009..This study will validate endogenous structural skin components as novel molecular Itargets for chemoprevention in skin photocarcinogenesis and photoaging and lead to a new class of Iphotoprotective agents. ..
- PHTHALOCYANINE PHOTOSENSITIZATION CYTOTOXIC MECHANISMSNANCY OLEINICK; Fiscal Year: 1990....
- Photosensitization of Oral BacteriaNIKOLAOS SOUKOS; Fiscal Year: 2004..In the same biofilm models the photodynamic effects of the PS will be established and PW-enhanced photosensitization of periodontopathogens by the PS will be evaluated. ..
- Photothermal Sensitization of Biological SystemsMichael Rodgers; Fiscal Year: 2003..In addition the team will investigate the propagation of thermal shock waves in biological materials. ..
- ULTRAVIOLET LIGHT INDUCED PHENOMENA IN BIOMEMBRANESIRENE KOCHEVAR; Fiscal Year: 2006..Human keratinocytes and fibroblasts will be supplemented with 7-DHC, and UVA-induced production of PGE2 and IL-lcc will measured. ..
- MECHANISMS FOR CHRONIC UVR-INDUCED DAMAGE TO SKINIRENE KOCHEVAR; Fiscal Year: 2003..Elastase inhibitors will also be employed in vivo. In vitro experiments using human dermal fibroblasts grown in contracted collagen gels or skin equivalents will be used to define mechanisms for the phenomena observed in vivo. ..
- Chk2 as a target for regulating senescence in skin neoplasiaArianna Kim; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- DNA Damage and Neurodegeneration in Cockayne SyndromeJames Cleaver; Fiscal Year: 2009..Successful conclusion of these studies will expand our knowledge of mechanisms of neurodegeneration and lay groundwork for development of therapeutic approaches for CS patients. ..
- THE FRAMINGHAM SCHOOL STUDY OF NEVI IN CHILDREN: SONIC IIAllan Halpern; Fiscal Year: 2008..And, they will permit education of clinicians about the changes that routinely occur in nevi in adolescence which, in turn, should lead to a reduction of the large number of unnecessary nevus excisions in this age group. ..
- Molecular pathogenesis of UVB-induced skin cancerDavid Bickers; Fiscal Year: 2008..Our animal models offer an innovative approach for assessing the molecular pathogenesis of UVB-induced SCCs and BCCs and could help create novel approaches to the prevention/treatment of human NMSCs. ..
- Photoreceptor Cell Vulnerability and Glutathione StatusBarry S Winkler; Fiscal Year: 2010..These outcomes should help in the design of therapeutic treatments for photoreceptor degenerations that are linked to an inadequate antioxidative defense mechanism. ..
- ENHANCEMENT OF PDT USING BIOLOGICAL RESPONSE MODIFIERSDavid A Bellnier; Fiscal Year: 2010....
- Osteopontin and microenvironment of initiated cellsPi Ling Chang; Fiscal Year: 2010..These proposed in vivo and in vitro studies will shed light on the molecular mechanism(s) by which a matricellular protein enhances the survival of transforming cells during early tumor promotion. ..
- Control of Eye Melanoma MetastsisHans E Grossniklaus; Fiscal Year: 2010..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
- Efficacy of Web-based Training in Skin Cancer TriageMartin Weinstock; Fiscal Year: 2007..If this course is found to be efficacious, it will be made freely available on the web, and we will plan efforts to encourage its broad dissemination. [unreadable] [unreadable]..
- SKIN SELF EXAMINATION FOR EARLY DETECTION OF MELANOMAMartin Weinstock; Fiscal Year: 2002..The knowledge and experiment thus gained will aid the continuing efforts to encourage SSE and reduce melanoma mortality. ..
- 2nd International Cervical Cancer ConferenceMichele Follen; Fiscal Year: 2002..Each session chair and speaker has been chosen based on his/her publications, funding and national reputation. ..
- Control of Eye Melanoma MetastasisHans Grossniklaus; Fiscal Year: 2003..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
- SUBMACULAR SURGERY TRIALS PATHOLOGY CENTERHans Grossniklaus; Fiscal Year: 2003..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
- Dermatomyositis Skin Disease Severity Measure ValidationJOSPEH JORIZZO; Fiscal Year: 2003..abstract_text> ..
- Colorectal Screening Capacity Building ConferenceDavid Alberts; Fiscal Year: 2003..Continued capacity building and future collaboration will also be woven into this conference to serve as a stone to build upon in the future. ..
- METABOLIC AND HOMEOSTATIC MECHANISMS IN RETINA AND RPEBarry Winkler; Fiscal Year: 2003..g., diamox) which have been reported to decrease retinal edema. A long-term goal of the second project is to understand better the nature of the interactions between the retina and RPE and factors regulating retinal detachment. ..
- Role of Osteopontin in Tumor PromotionPi Ling Chang; Fiscal Year: 2005..Together, these studies will provide a better understanding of the role of OPN in tumor promotion and may contribute to the design of a mechanism-based strategy for cancer prevention. ..
- The XP Variant: A Human Mutator Gene for UV DamageJames Cleaver; Fiscal Year: 2005..We will express hRad3O on the keratin 14 promoter for over-expression in the skin, and make targeted knockout of mRad3O in vivo to identify roles for hRad3O in promoting and preventing carcinogenesis. ..
- ENZYME DEFECTS IN DISORDERS OF PROTOPORPHYRIN METABOLISMJoseph Bloomer; Fiscal Year: 2005..The proposal thus is designed to define a critical relationship between FECH gene expression and phenotype in EPP which will lead to better genetic counseling and therapy. ..
- Basal Cell Carcinoma:Molecular Pathogenesis & PreventionDavid Bickers; Fiscal Year: 2006..It is likely that novel anti-carcinogenic agents potentially suitable for testing in the human population could be identified as a result of the studies in this proposal. ..
- Cell cycle regulatory proteins in UVB-skin carcinogenesArianna Kim; Fiscal Year: 2007..In addition, our studies could provide a rationale to develop new therapeutic tools targeted towards the protein degradation machinery. ..
- MECHANISMS OF CUTANEOUS INJURY IN LUPUS ERYTHEMATOSUSRichard Sontheimer; Fiscal Year: 2001....