psoriasis

Summary

Summary: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

Top Publications

  1. ncbi Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis
    Dorothea M Sommer
    Department of Dermatology, University of Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
    Arch Dermatol Res 298:321-8. 2006
  2. pmc Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
    Lam C Tsoi
    Department of Biostatistics, Center for Statistical Genetics, University of Michigan Ann Arbor, MI, USA
    Nat Genet 44:1341-8. 2012
  3. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
  4. doi Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    Craig Leonardi
    Department of Dermatology, Saint Louis University School of Medicine, St Louis, MO, USA
    N Engl J Med 366:1190-9. 2012
  5. doi Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    Kim A Papp
    Probity Medical Research, Waterloo, ON, Canada
    N Engl J Med 366:1181-9. 2012
  6. ncbi Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    Yan Zheng
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 445:648-51. 2007
  7. ncbi Development, cytokine profile and function of human interleukin 17-producing helper T cells
    Nicholas J Wilson
    Department of Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, California 94304 1104, USA
    Nat Immunol 8:950-7. 2007
  8. pmc Meta-analysis derived (MAD) transcriptome of psoriasis defines the "core" pathogenesis of disease
    Suyan Tian
    Center for Clinical and Translational Science, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 7:e44274. 2012
  9. pmc Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation
    Yihua Cai
    Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 20025, PR China
    Immunity 35:596-610. 2011
  10. doi The IL-23/Th17 axis in the immunopathogenesis of psoriasis
    Antonella Di Cesare
    St John s Institute of Dermatology, King s College London School of Medicine and NIHR Biomedical Research Centre, London, UK
    J Invest Dermatol 129:1339-50. 2009

Research Grants

Detail Information

Publications390 found, 100 shown here

  1. ncbi Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasis
    Dorothea M Sommer
    Department of Dermatology, University of Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
    Arch Dermatol Res 298:321-8. 2006
    ..b>Psoriasis as a chronic inflammatory skin disorder is characterized by a variety of immunologic and inflammatory changes ..
  2. pmc Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
    Lam C Tsoi
    Department of Biostatistics, Center for Statistical Genetics, University of Michigan Ann Arbor, MI, USA
    Nat Genet 44:1341-8. 2012
    To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 ..
  3. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
    b>Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases and 1,436 controls of European ancestry...
  4. doi Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    Craig Leonardi
    Department of Dermatology, Saint Louis University School of Medicine, St Louis, MO, USA
    N Engl J Med 366:1190-9. 2012
    Type 17 helper T cells have been suggested to play a pathological role in psoriasis. They secrete several proinflammatory cytokines, including interleukin-17A (also known as interleukin-17)...
  5. doi Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    Kim A Papp
    Probity Medical Research, Waterloo, ON, Canada
    N Engl J Med 366:1181-9. 2012
    ..double-blind, placebo-controlled, dose-ranging study, we assessed the efficacy and safety of brodalumab (AMG 827), a human anti-interleukin-17-receptor monoclonal antibody, for the treatment of moderate-to-severe plaque psoriasis.
  6. ncbi Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    Yan Zheng
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 445:648-51. 2007
    b>Psoriasis is a chronic inflammatory skin disease characterized by hyperplasia of the epidermis (acanthosis), infiltration of leukocytes into both the dermis and epidermis, and dilation and growth of blood vessels...
  7. ncbi Development, cytokine profile and function of human interleukin 17-producing helper T cells
    Nicholas J Wilson
    Department of Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Palo Alto, California 94304 1104, USA
    Nat Immunol 8:950-7. 2007
    ..Our data collectively indicate that human and mouse T(H)-17 cells require distinct factors during differentiation and that human T(H)-17 cells may regulate innate immunity in epithelial cells...
  8. pmc Meta-analysis derived (MAD) transcriptome of psoriasis defines the "core" pathogenesis of disease
    Suyan Tian
    Center for Clinical and Translational Science, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 7:e44274. 2012
    The cause of psoriasis, a common chronic inflammatory skin disease, is not fully understood...
  9. pmc Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation
    Yihua Cai
    Department of Dermatology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 20025, PR China
    Immunity 35:596-610. 2011
    Interleukin-23 (IL-23) and CD4(+) T helper 17 (Th17) cells are thought to be critical in psoriasis pathogenesis. Here, we report that IL-23 predominantly stimulated dermal γδ T cells to produce IL-17 that led to disease progression...
  10. doi The IL-23/Th17 axis in the immunopathogenesis of psoriasis
    Antonella Di Cesare
    St John s Institute of Dermatology, King s College London School of Medicine and NIHR Biomedical Research Centre, London, UK
    J Invest Dermatol 129:1339-50. 2009
    Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part ..
  11. doi Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis
    Leslie van der Fits
    Department of Dermatology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 182:5836-45. 2009
    Topical application of imiquimod (IMQ), a TLR7/8 ligand and potent immune activator, can induce and exacerbate psoriasis, a chronic inflammatory skin disorder. Recently, a crucial role was proposed for the IL-23/IL-17 axis in psoriasis...
  12. pmc Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis (GSEA)
    Mayte Suárez-Fariñas
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 5:e10247. 2010
    Our objective was to develop a consistent molecular definition of psoriasis. There have been several published microarray studies of psoriasis, and we compared disease-related genes identified across these different studies of psoriasis ..
  13. pmc Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis
    Rafael de Cid
    Genes and Disease Programme, Centre for Genomic Regulation CRG and Public Health and Epidemiology Network Biomedical Research Center CIBERESP, 08003 Barcelona, Spain
    Nat Genet 41:211-5. 2009
    b>Psoriasis is a common inflammatory skin disease with a prevalence of 2-3% in individuals of European ancestry...
  14. ncbi IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Eur J Immunol 36:1309-23. 2006
    ..In summary, despite similarities, IFN-gamma primarily amplifies inflammation, while IL-22 may be important in the innate immunity and reorganization of epithelia...
  15. ncbi Pathogenesis and therapy of psoriasis
    Michelle A Lowes
    Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, Box 178, New York, New York 10021, USA
    Nature 445:866-73. 2007
    b>Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings...
  16. doi Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
    Michelle A Lowes
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10021, USA
    J Invest Dermatol 128:1207-11. 2008
    The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells...
  17. pmc Circulating Th17, Th22, and Th1 cells are increased in psoriasis
    Shinji Kagami
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA
    J Invest Dermatol 130:1373-83. 2010
    Th17, Th22, and Th1 cells are detected in psoriatic skin lesions and implicated in psoriasis pathogenesis, but inflammatory T cell numbers in blood, as well as the relative importance of each cell type, is unclear...
  18. pmc Genome-wide association analysis identifies three psoriasis susceptibility loci
    Philip E Stuart
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Genet 42:1000-4. 2010
    We carried out a meta-analysis of two recent psoriasis genome-wide association studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls...
  19. pmc Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
    Michelle A Lowes
    Laboratory for Investigative Dermatology and Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:19057-62. 2005
    ..find that CD11c(+) cells with many markers of dendritic cells (DCs) are a major cell type in the skin lesions of psoriasis. These CD11c(+) cells, which are evident in both epidermis and dermis, are the sites for the expression of two ..
  20. doi Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    Craig L Leonardi
    Saint Louis University Medical School, St Louis, MO, USA
    Lancet 371:1665-74. 2008
    Interleukins 12 and 23 have important roles in the pathophysiology of psoriasis. We assessed ustekinumab, a human monoclonal antibody directed against these cytokines, for the treatment of psoriasis.
  21. doi Global epidemiology of psoriasis: a systematic review of incidence and prevalence
    Rosa Parisi
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
    J Invest Dermatol 133:377-85. 2013
    The worldwide incidence and prevalence of psoriasis is poorly understood. To better understand this, we performed a systematic review of published population-based studies on the incidence and prevalence of psoriasis...
  22. ncbi Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    Peck Y Ong
    Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    N Engl J Med 347:1151-60. 2002
    ..normal skin these peptides are negligible, but they accumulate in skin affected by inflammatory diseases such as psoriasis. We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients ..
  23. pmc IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
    Jason R Chan
    Discovery Research, Schering Plough Biopharma Formerly DNAX Research, Inc, Palo Alto, CA 94304, USA
    J Exp Med 203:2577-87. 2006
    Aberrant cytokine expression has been proposed as an underlying cause of psoriasis, although it is unclear which cytokines play critical roles. Interleukin (IL)-23 is expressed in human psoriasis and may be a master regulator cytokine...
  24. pmc Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome
    Cailin E Joyce
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 20:4025-40. 2011
    b>Psoriasis is a chronic and complex inflammatory skin disease with lesions displaying dramatically altered mRNA expression profiles. However, much less is known about the expression of small RNAs...
  25. pmc Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis
    Mayte Suárez-Fariñas
    Laboratory of Investigative Dermatology, Rockefeller University, New York, New York, USA
    J Invest Dermatol 132:2552-64. 2012
    b>Psoriasis is a complex disease with an expanding definition of its pathological features...
  26. pmc Combined use of laser capture microdissection and cDNA microarray analysis identifies locally expressed disease-related genes in focal regions of psoriasis vulgaris skin lesions
    Hiroshi Mitsui
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10065 6399, USA
    J Invest Dermatol 132:1615-26. 2012
    b>Psoriasis vulgaris is a complex disease characterized by alterations in growth and differentiation of epidermal keratinocytes, as well as a marked increase in leukocyte populations...
  27. pmc The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses
    Michelle A Lowes
    Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Trends Immunol 34:174-81. 2013
    b>Psoriasis is a complex inflammatory process resulting from activation of the well-defined interleukin (IL)-23/T17 cytokine axis...
  28. pmc Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis
    Andrew M Lin
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 187:490-500. 2011
    IL-17 and IL-23 are known to be absolutely central to psoriasis pathogenesis because drugs targeting either cytokine are highly effective treatments for this disease...
  29. pmc A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
    Amy Strange
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Nat Genet 42:985-90. 2010
    To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls...
  30. doi Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study
    Ole Ahlehoff
    Department of Cardiology, Copenhagen University Hospital Gentofte, DK 2900 Hellerup, Denmark
    Eur Heart J 33:2054-64. 2012
    b>Psoriasis is a chronic inflammatory disease and inflammation contributes to the pathogenesis of atrial fibrillation (AF) and ischaemic stroke. We therefore investigated the risk of these endpoints in patients with psoriasis.
  31. doi IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A
    Heather L Rizzo
    Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 186:1495-502. 2011
    IL-23 and Th17 cells producing IL-17A and IL-22 are found in excess in skin affected by psoriasis. Previous studies showed that IL-22, but not IL-17A, mediates psoriasis-like epidermal hyperplasia following recombinant murine (rm)IL-23 ..
  32. pmc Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
    Eva Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany
    Nat Genet 42:991-5. 2010
    b>Psoriasis is a multifactorial skin disease characterized by epidermal hyperproliferation and chronic inflammation, the most common form of which is psoriasis vulgaris (PsV)...
  33. pmc Skin immune sentinels in health and disease
    Frank O Nestle
    St John s Institute of Dermatology, King s College London, UK
    Nat Rev Immunol 9:679-91. 2009
    ..This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease...
  34. doi Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis
    Andrea Chiricozzi
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA
    J Invest Dermatol 131:677-87. 2011
    b>Psoriasis is a complex inflammatory disease mediated by tumor necrosis factor (TNF)-α and cytokines secreted by specialized T-cell populations, e.g., IL-17, IL-22, and IFN-γ...
  35. pmc Association analyses identify six new psoriasis susceptibility loci in the Chinese population
    Liang Dan Sun
    Institute of Dermatology and Department of Dermatology at No 1 Hospital, Anhui Medical University, Hefei, Anhui, China
    Nat Genet 42:1005-9. 2010
    We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from ..
  36. ncbi Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
    Roberto Lande
    Department of Immunology, M D Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA
    Nature 449:564-9. 2007
    ..identify the antimicrobial peptide LL37 (also known as CAMP) as the key factor that mediates pDC activation in psoriasis, a common autoimmune disease of the skin...
  37. doi Psoriasis
    Gayathri K Perera
    St John s Institute of Dermatology, King s College London, London SE1 9RT, United Kingdom
    Annu Rev Pathol 7:385-422. 2012
    b>Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints...
  38. pmc Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
    Dipyaman Ganguly
    Department of Immunology, The University of Texas M D Anderson Cancer Center, TX 77030, USA
    J Exp Med 206:1983-94. 2009
    ..In psoriasis, however, plasmacytoid DCs (pDCs) sense self-DNA that is transported to endosomal TLR9 upon forming a complex ..
  39. pmc Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice
    Stanislav Pantelyushin
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    J Clin Invest 122:2252-6. 2012
    b>Psoriasis is a common, relapsing inflammatory skin disease characterized by erythematous scaly plaques...
  40. doi Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong TH17/TH1 T-cell responses
    Anja Hänsel
    Faculty of Medicine, Institute of Immunology, Technical University of Dresden, Dresden, Germany
    J Allergy Clin Immunol 127:787-94.e1-9. 2011
    b>Psoriasis is a chronic inflammatory skin disease that is considered to result from activated T cells stimulated by a population of inflammatory dermal dendritic cells (DCs)...
  41. pmc Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    Lisa C Zaba
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 204:3183-94. 2007
    Biological agents have dramatically improved treatment options for patients with severe psoriasis. Etanercept (tumor necrosis factor [TNF] receptor-immunoglobulin fusion protein) is an effective treatment for many psoriasis patients, and ..
  42. pmc A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    Ying Liu
    Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 4:e1000041. 2008
    A genome-wide association study was performed to identify genetic factors involved in susceptibility to psoriasis (PS) and psoriatic arthritis (PSA), inflammatory diseases of the skin and joints in humans...
  43. ncbi Risk of myocardial infarction in patients with psoriasis
    Joel M Gelfand
    Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    JAMA 296:1735-41. 2006
    b>Psoriasis is the most common T-helper cell type 1 (T(H)1) immunological disease. Evidence has linked T(H)1 diseases to myocardial infarction (MI)...
  44. pmc Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways
    K E Nograles
    Laboratory of Investigative Dermatology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Br J Dermatol 159:1092-102. 2008
    b>Psoriasis vulgaris is an inflammatory skin disease mediated by Th1 and Th17 cytokines, yet the relative contribution of interferon (IFN)-gamma, interleukin (IL)-17 and IL-22 on disease pathogenesis is still unknown.
  45. pmc Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo
    Malgorzata Romanowska
    Division of Experimental Medicine, University of Dundee, Dundee, United Kingdom
    PLoS ONE 5:e9701. 2010
    b>Psoriasis is one of the most frequent skin diseases world-wide. The disease impacts enormously on affected patients and poses a huge financial burden on health care providers...
  46. ncbi Psoriasis
    Michael P Schön
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, and the Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 352:1899-912. 2005
  47. pmc Type I interferon: potential therapeutic target for psoriasis?
    Yihong Yao
    MedImmune, Inc, Gaithersburg, Maryland, United States of America
    PLoS ONE 3:e2737. 2008
    b>Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation...
  48. pmc Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models
    Johann E Gudjonsson
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 130:1829-40. 2010
    To further elucidate molecular alterations in psoriasis, we performed a gene expression study of 58 paired lesional and uninvolved psoriatic and 64 control skin samples...
  49. pmc Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci
    David Ellinghaus
    Institute of Clinical Molecular Biology, Christian Albrechts University, 24105 Kiel, Germany
    Am J Hum Genet 90:636-47. 2012
    b>Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically, and therapeutically connected, but little is known about their shared genetic causes...
  50. doi Psoriasis: rationale for targeting interleukin-17
    G Girolomoni
    Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy
    Br J Dermatol 167:717-24. 2012
    The exact pathogenesis of plaque psoriasis remains to be fully determined, but it is thought to depend on environmental and genetic factors that stimulate dysregulated innate and adaptive immune responses in the skin...
  51. doi Anti-cytokine therapies for psoriasis
    Kristine E Nograles
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA
    Exp Cell Res 317:1293-300. 2011
    Current approaches for the treatment of psoriasis with anti-cytokine therapies involve the blockade of TNF-α, or the p40 sub-unit of IL-12 and IL-23...
  52. doi Contrasting pathogenesis of atopic dermatitis and psoriasis--part I: clinical and pathologic concepts
    Emma Guttman-Yassky
    Laboratory for Investigative Dermatology, Rockefeller University, New York, NY 10065, USA
    J Allergy Clin Immunol 127:1110-8. 2011
    Atopic dermatitis and psoriasis are 2 of the most common inflammatory skin diseases...
  53. doi Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions
    Batya B Davidovici
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA
    J Invest Dermatol 130:1785-96. 2010
    b>Psoriasis is now classified as an immune-mediated inflammatory disease (IMID) of the skin. It is being recognized that patients with various IMIDs, including psoriasis, are at higher risk of developing "systemic" co-morbidities, e.g...
  54. pmc Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis
    Ulrike Huffmeier
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Nat Genet 42:996-9. 2010
    ..joint disease that is distinct from other chronic arthritides and which is frequently accompanied by psoriasis vulgaris (PsV) and seronegativity for rheumatoid factor...
  55. doi Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study
    K A Papp
    Probity Medical Research, 135 Union Street East, Waterloo, ON N2J 1C4, Canada
    Br J Dermatol 167:668-77. 2012
    Tofacitinib is a novel, oral Janus kinase inhibitor under investigation as a potential treatment for plaque psoriasis.
  56. pmc IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis
    James G Krueger
    The Rockefeller University, New York, NY 10065, USA
    J Allergy Clin Immunol 130:145-54.e9. 2012
    In subjects with psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence suggests that the T(H)17 cell cytokine IL-17A (IL-17) might play a role in disease pathogenesis.
  57. pmc Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
    Kamran Ghoreschi
    Department of Dermatology, University Medical Center and 2 Interfaculty Institute for Biochemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    J Exp Med 208:2291-303. 2011
    Fumarates improve multiple sclerosis (MS) and psoriasis, two diseases in which both IL-12 and IL-23 promote pathogenic T helper (Th) cell differentiation. However, both diseases show opposing responses to most established therapies...
  58. pmc Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    Edmund Lee
    Laboratory for Investigative Dermatology, The Rockefeller University Hospital, P O Box 178, 1230 York Avenue, New York, NY 10021, USA
    J Exp Med 199:125-30. 2004
    b>Psoriasis is a type I-deviated disease characterized by the presence of interferon (IFN)-gamma and multiple IFN-related inflammatory genes in lesions...
  59. doi Profiles of Foxp3+ regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides
    T Fujimura
    Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryo machi 1 1, Aoba ku, Sendai 980 8574, Japan
    Br J Dermatol 158:1256-63. 2008
    ..Recently, it has been demonstrated that a Treg population resides in normal human skin. However, only a few studies have demonstrated the presence of Foxp3+ Tregs in inflammatory skin disorders...
  60. doi IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice
    Astrid B Van Belle
    Ludwig Institute for Cancer Research, B 1200 Brussels, Belgium
    J Immunol 188:462-9. 2012
    b>Psoriasis is a common chronic autoimmune skin disease of unknown cause that involves dysregulated interplay between immune cells and keratinocytes...
  61. doi Contrasting pathogenesis of atopic dermatitis and psoriasis--part II: immune cell subsets and therapeutic concepts
    Emma Guttman-Yassky
    Laboratory for Investigative Dermatology, Rockefeller University, New York, NY 10065, USA
    J Allergy Clin Immunol 127:1420-32. 2011
    Atopic dermatitis (AD) and psoriasis are among the most common inflammatory skin diseases...
  62. pmc Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis
    William R Swindell
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18266. 2011
    Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments...
  63. pmc Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin
    Johann E Gudjonsson
    Department of Dermatology, University of Michigan, 1910 Taubman Center, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 129:2795-804. 2009
    b>Psoriasis is a genetically determined inflammatory skin disease...
  64. doi Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis
    Christopher E M Griffiths
    University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
    N Engl J Med 362:118-28. 2010
    Biologic agents offer a range of new therapeutic options for patients with psoriasis; however, the relative benefit-risk profiles of such therapies are not well known...
  65. doi Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    Wolfgang Hueber
    Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland
    Sci Transl Med 2:52ra72. 2010
    ..diseases, we investigated the efficacy and safety of AIN457, a human antibody to IL-17A, in patients with psoriasis, rheumatoid arthritis, and chronic noninfectious uveitis...
  66. ncbi Unfavorable cardiovascular risk profiles in untreated and treated psoriasis patients
    M Wakkee
    Department of Dermatology, University Medical Center Rotterdam, The Netherlands
    Atherosclerosis 190:1-9. 2007
    b>Psoriasis is a chronic inflammatory skin disease that is associated with an increased cardiovascular risk profile...
  67. doi IL-17-producing CD8+ T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines
    Consuelo Ortega
    Unidad de Inmunologia, Facultad de Medicina, Universidad de Cordoba, Cordoba, Spain
    J Leukoc Biol 86:435-43. 2009
    IL-17-producing CD4+ T lymphocytes (Th17) are currently considered relevant participants in the pathogenesis of psoriasis skin lesions...
  68. pmc Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis
    Pieter C M Res
    Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 5:e14108. 2010
    Although recent studies indicate a crucial role for IL-17A and IL-22 producing T cells in the pathogenesis of psoriasis, limited information is available on their frequency and heterogeneity and their distribution in skin in situ.
  69. pmc Rare and common variants in CARD14, encoding an epidermal regulator of NF-kappaB, in psoriasis
    Catherine T Jordan
    Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 90:796-808. 2012
    b>Psoriasis is a common inflammatory disorder of the skin and other organs...
  70. pmc Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes
    Lisa C Zaba
    Laboratory for Investigative Dermatology, Rockefeller University, New York, NY 10065, USA
    J Allergy Clin Immunol 124:1022-10.e1-395. 2009
    TNF inhibitors have revolutionized the treatment of psoriasis vulgaris as well as psoriatic and rheumatoid arthritis and Crohn disease...
  71. pmc A subpopulation of CD163-positive macrophages is classically activated in psoriasis
    Judilyn Fuentes-Duculan
    Laboratory for Investigative Dermatology, Rockefeller University, New York, New York 10065, USA
    J Invest Dermatol 130:2412-22. 2010
    ..innate immune system, and their study is essential to gain greater understanding of the inflammatory nature of psoriasis. We used immunohistochemistry and double-label immunofluorescence to characterize CD163(+) macrophages in ..
  72. doi Molecular dissection of psoriasis: integrating genetics and biology
    James T Elder
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Invest Dermatol 130:1213-26. 2010
    b>Psoriasis is a common and debilitating disease of the skin, nails, and joints, with an acknowledged but complex genetic basis...
  73. ncbi Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case-control study
    P Gisondi
    Section of Dermatology, Department of Biomedical and Surgical Science, University of Verona, Verona, Italy
    Br J Dermatol 157:68-73. 2007
    b>Psoriasis is a chronic inflammatory disease associated with an increased cardiovascular risk. Metabolic syndrome is a significant predictor of cardiovascular events.
  74. pmc Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis
    Ilona Kryczek
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Immunol 181:4733-41. 2008
    ..In this study, we demonstrate increased the number of CD4(+) and CD8(+) IL-17(+) T cells in skin lesions of psoriasis. Furthermore, we show that myeloid APCs potently support induction of IL-17(+) T cells, and that this activity ..
  75. pmc Association of β-defensin copy number and psoriasis in three cohorts of European origin
    Philip E Stuart
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA
    J Invest Dermatol 132:2407-13. 2012
    A single previous study has demonstrated significant association of psoriasis with copy number of β-defensin genes, using DNA from psoriasis cases and controls from Nijmegen and Erlangen...
  76. ncbi TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques
    Alice B Gottlieb
    Clinical Research Center, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    J Immunol 175:2721-9. 2005
    ..Because psoriasis plaques are accessible to repeat biopsy, the effect of TNF/lymphotoxin blockade with etanercept (soluble TNFR) ..
  77. doi Successful treatment of moderate to severe plaque psoriasis with the PEGylated Fab' certolizumab pegol: results of a phase II randomized, placebo-controlled trial with a re-treatment extension
    K Reich
    Dermatologikum Hamburg, Stephansplatz 5, 20354 Hamburg, Germany
    Br J Dermatol 167:180-90. 2012
    ..Certolizumab pegol (CZP) is a PEGylated antitumour necrosis factor agent...
  78. pmc Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom
    Sinead M Langan
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Invest Dermatol 132:556-62. 2012
    Increasing epidemiological evidence suggests independent associations between psoriasis and cardiovascular and metabolic disease...
  79. pmc The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings
    David A Martin
    Medical Sciences, Amgen, Seattle, WA, USA
    J Invest Dermatol 133:17-26. 2013
    Although the histological changes seen in psoriasis have long been well characterized, the underlying cellular and molecular mechanisms have only begun to be elucidated over the past 20 years...
  80. doi Comorbidities in patients with psoriasis
    Alice B Gottlieb
    Tufts Medical Center, Boston, Mass, USA
    Am J Med 122:1150.e1-9. 2009
    b>Psoriasis is a common chronic inflammatory disease that is associated with serious comorbidities, including psoriatic arthritis, reduced quality of life, depression, malignancy, and cardiovascular comorbidities...
  81. doi The roles of cells and cytokines in the pathogenesis of psoriasis
    Susana Coimbra
    Biochemistry Laboratory, Department of Biological Science, Faculty of Pharmacy and Institute of Molecular and Cellular Biology, University of Porto, Porto, Portugal
    Int J Dermatol 51:389-95; quiz 395-8. 2012
    b>Psoriasis is considered an immune chronic disease in which T cells are accepted as important. Nowadays, it is believed that psoriasis is most likely a T helper (Th)1/Th17 induced inflammatory disease...
  82. doi Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study
    K A Papp
    Probity Medical Research, 135 Union Street East, Waterloo, ON N2J 1C4, Canada
    Br J Dermatol 168:412-21. 2013
    Conventional systemic therapies for plaque psoriasis have not fully met the needs of patients, and although current biologic treatments are generally well tolerated, concerns exist with respect to long-term safety...
  83. doi Psoriasis and the risk of diabetes mellitus: a systematic review and meta-analysis
    April W Armstrong
    Department of Dermatology, University of California, Davis, Sacramento 95816, USA
    JAMA Dermatol 149:84-91. 2013
    To compare the prevalence and incidence of type 2 diabetes mellitus between patients with psoriasis and those without psoriasis.
  84. doi Economic evaluation of systemic therapies for moderate to severe psoriasis
    S Sizto
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, Vancouver, BC, Canada
    Br J Dermatol 160:1264-72. 2009
    New biologics have dramatically changed therapeutic options for psoriasis, albeit at additional cost.
  85. doi Tuberculosis screening in patients with psoriasis before antitumour necrosis factor therapy: comparison of an interferon-gamma release assay vs. tuberculin skin test
    E Laffitte
    Clinic of Dermatology, University Medical Hospital, CH 1211 Geneva, Switzerland
    Br J Dermatol 161:797-800. 2009
    ..For detecting LTBI, the tuberculin skin test (TST) has low sensitivity and specificity. Interferon-gamma release assays (IGRA) have been shown to be more sensitive and specific than TST...
  86. doi Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study
    O Ahlehoff
    Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark
    J Intern Med 270:147-57. 2011
    The magnitude of the cardiovascular risk from psoriasis and psoriatic arthritis is debated. We therefore investigated the psoriasis-related risk of adverse cardiovascular events and mortality.
  87. pmc Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6
    Eva Riveira-Munoz
    Center for Genomic Regulation and Public Health and Epidemiology Network Biomedical Research Center, CIBERESP, Barcelona, Spain
    J Invest Dermatol 131:1105-9. 2011
    A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis ..
  88. pmc IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells
    Kristine E Nograles
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065, USA
    J Allergy Clin Immunol 123:1244-52.e2. 2009
    b>Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases. An upregulated TH17/IL-23 pathway was demonstrated in psoriasis...
  89. pmc Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells
    Lisa C Zaba
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10065, USA
    J Invest Dermatol 129:79-88. 2009
    Myeloid dermal dendritic cells (DCs) accumulate in chronically inflamed tissues such as psoriasis. The importance of these cells for psoriasis pathogenesis is suggested by comparative T-cell and DC-cell counts, where DCs outnumber T ..
  90. doi Psoriasis in a nationwide cohort study of patients with celiac disease
    Jonas F Ludvigsson
    Department of Pediatrics, Orebro University Hospital, Orebro, Sweden
    J Invest Dermatol 131:2010-6. 2011
    Earlier studies on the association between celiac disease (CD) and psoriasis show contradictory results. The purpose of this study was to assess the risk of psoriasis in patients with biopsy-verified CD...
  91. pmc Cutting edge: A critical functional role for IL-23 in psoriasis
    Giulia Tonel
    St John s Institute of Dermatology, National Institute for Health Research Biomedical Research Centre, King s College London, London, United Kingdom
    J Immunol 185:5688-91. 2010
    ..with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this study, we provide a comprehensive analysis of IL-23 and its receptor in psoriasis and demonstrate its ..
  92. doi Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality
    Srjdan Prodanovich
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Arch Dermatol 145:700-3. 2009
    To examine the cardiovascular risk factors in patients with psoriasis and the association between psoriasis and coronary artery, cerebrovascular, and peripheral vascular diseases.
  93. ncbi The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders
    M Frohm
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 272:15258-63. 1997
    ..We propose a protective role for LL-37, when the integrity of the skin barrier is damaged, participating in the first line of defense, and preventing local infection and systemic invasion of microbes...
  94. pmc Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis
    Lisa C Zaba
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065, USA
    J Allergy Clin Immunol 125:1261-1268.e9. 2010
    Previous work has identified CD11c(+)CD1c(-) dendritic cells (DCs) as the major "inflammatory" dermal DC population in patients with psoriasis vulgaris and CD1c(+) DCs as the "resident" cutaneous DC population.
  95. ncbi The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis
    Susan M Sa
    Department of Pathology, Genentech, South San Francisco, CA 94080, USA
    J Immunol 178:2229-40. 2007
    ..These cytokines also induce expression of the psoriasis-associated protein S100A7 and keratin 16 in RHE and cause persistent activation of Stat3 with nuclear ..
  96. ncbi Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies
    A M Bowcock
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 10:1793-805. 2001
    Approximately 2% of the Caucasian population is affected by psoriasis (PS); a chronic inflammatory skin disease triggered by both genetic and environmental risk factors...
  97. pmc Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Eur Heart J 31:1000-6. 2010
    b>Psoriasis is a common chronic inflammatory T-helper cell-1/17 mediated skin disease...
  98. ncbi Immunopathogenesis of psoriasis
    Robert Sabat
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Berlin, Germany
    Exp Dermatol 16:779-98. 2007
    b>Psoriasis is a chronic skin disease that affects about 1.5% of the Caucasian population and is characterized by typical macroscopic and microscopic skin alterations...
  99. ncbi Prevalence of cardiovascular risk factors in patients with psoriasis
    Andrea L Neimann
    Dermatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Acad Dermatol 55:829-35. 2006
    Previous studies suggest that patients hospitalized for psoriasis have an increased frequency of a variety of cardiovascular comorbidities...
  100. doi IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not
    Kerstin Wolk
    Interdisciplinary Group of Molecular Immunopathology, Dermatology Medical Immunology, University Hospital Charite, Chariteplatz 1, 10117, Berlin, Germany
    J Mol Med (Berl) 87:523-36. 2009
    b>Psoriasis is a common chronic skin disease with a largely unknown pathogenesis...
  101. pmc Psoriasis and metabolic disease: epidemiology and pathophysiology
    Rahat S Azfar
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Curr Opin Rheumatol 20:416-22. 2008
    The scientific literature linking psoriasis to metabolic syndrome, and its components, as well as atherosclerosis and myocardial infarction has rapidly expanded...

Research Grants70

  1. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..drugs under intensive investigation for amelioration of numerous conditions including Crohn's disease, psoriasis and psoriatic arthritis, systemic lupus erythematosus;multiple sclerosis;Type I Diabetes, and as anti-rejection ..
  2. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..evidences for the role of nerve growth factor (NGF) and its receptor system (NGF-R) in the pathogenesis of psoriasis and psoriatic arthritis (PsA)...
  3. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..Ustekinumab) which suppress Th17 cytokine elaboration have recently been approved for the treatment of psoriasis;however this drug can also suppress Th1 immunity and theoretically increase the risk of infection with ..
  4. Modeling TH17 Cells in Acute GVHD
    JONATHAN STUART SERODY; Fiscal Year: 2010
    ..Our collaborators at Wyeth found that Th17 cells mediated extensive skin disease in a transplantation model for psoriasis and that blocking the function of IL-22 produced by Th17 cells greatly diminished disease severity...
  5. Mindfulness Based Stress Reduction as an Adjunctive Treatment for Psoriasis
    Jan A Moynihan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psoriasis is a chronic inflammatory disease of the skin that affects between 2-3% of Americans...
  6. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..of psoriatic disease because of their memory phenotype and the ability of activated T lymphocytes to induce psoriasis in transplanted nonlesional skin in the SCID mouse-human skin xenograft model...
  7. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..secondary hyperparathyroidism in chronic kidney disease, and to a lesser degree used to treat osteoporosis and psoriasis. One of the reasons for this is due to the narrow therapeutic window of current VDRMs in the 1-4-fold range as ..
  8. Biologic Activities of IL-36 Cytokines in Psoriasis
    Andrew Johnston; Fiscal Year: 2013
    ..the Department of Immunology at the National University Hospital, Iceland, where I gained extensive training in psoriasis immunology and genetics, generating 6 publications and 2 review articles. I subsequently joined Dr. J.T...
  9. A Systems Biology Approach for Pediatric and Adult Autoimmune Diseases
    MARIA VIRGINIA PASCUAL; Fiscal Year: 2013
    ..The Center will deliver: 1) Innovative clinical trials targeting specific cytokines in psoriasis &dermatomyositis. 2) Development of biomarkers for dermatomyositis, psoriasis, lupus and multiple sclerosis...
  10. Delivery of biologically active nucleic acids to epidermal cells
    ROGER L contact KASPAR; Fiscal Year: 2010
    ..cause disease in the skin, and common inflammatory diseases affecting several percent of the population, such as psoriasis, have well-understood molecular pathways that could be the targets of nucleic acid therapeutics...
  11. The Role of CRACM1 in the Pathogenesis of Systemic Lupus Erythematosus
    Peter C Chien; Fiscal Year: 2013
    ..He also specializes in psoriasis and has done numerous clinical studies of this disease. Dr...
  12. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    ..Mast cells release a variety of puritogens that mediate allergy-evoked itch, psoriasis and eczema, and anti-histamines are not always effective in treating the full spectrum of allergic disorders...
  13. SIMULATION OF PROTON AND HYDRIDE TRANSFER IN ENZYMES
    Sharon Hammes Schiffer; Fiscal Year: 2010
    ..relevant in that inhibitors have been used as drug agents to treat diseases such as asthma, atherosclerosis, psoriasis, and cancer...
  14. NHERF-1 and dopamine-mediated regulation of renal phosphate transport.
    Edward J Weinman; Fiscal Year: 2013
    ..the role of NHERF-1 in other physiologic and pathophysiologic processes such as nephrolithiasis, schizophrenia, psoriasis, aggressive forms of estrogen receptor positive breast cancer, and nerve deafness (Usher's syndrome). ...
  15. GILT and regulation of Treg development in cutaneous autoimmunity
    KAREN TARASZKA HASTINGS; Fiscal Year: 2013
    ..play a critical role in the prevention of cutaneous autoimmune and inflammatory diseases, such as vitiligo, psoriasis, atopic dermatitis and systemic lupus erythematosus...
  16. Neurogenic inflammation and psoriasiform dermatitis
    NICOLE LEANNE WARD; Fiscal Year: 2013
    ..These results imply a role for the nervous system in maintaining and exacerbating the psoriasis phenotype;however the role and contribution of nerves to the cellular and molecular mechanisms mediating ..
  17. Genome-wide SNP association in psoriasis
    ANNE MARY BOWCOCK; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Psoriasis (Ps) is a common chronic inflammatory skin disease affecting approximately 2-3% of individuals of European ancestry...
  18. Characterization of Enhancers in the Epidermal Differentiation Complex
    CRISTINA DE GUZMAN STRONG; Fiscal Year: 2012
    Atopic dermatitis (AD) and psoriasis are two inflammatory skin diseases that affect over 22.5 million Americans collectively and are burdening the U.S. economy with over $7.5 billion dollars in management and quality-of-life issue costs...
  19. Pathophysiology of Adult T-cell Leukemia/Lymphoma
    UTPAL P DAVE; Fiscal Year: 2013
    ..JAK3 inhibitor currently being tested in patients with autoimmune diseases such as rheumatoid arthritis and psoriasis. Tofacitinib has been reported to have efficacy in phase III trials of rheumatoid arthritis and is the first ..
  20. Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation,
    ARUP K INDRA; Fiscal Year: 2012
    ..defects are also believed to contribute to several hereditary and acquired inflammatory skin disorders, such as psoriasis and atopic dermatitis (AD)...
  21. The role of TNF-Alpha in cutaneous integrity
    Victoria P Werth; Fiscal Year: 2013
    ..In the other direction, new medicines to inhibit TNFa are widely used therapeutically in Veterans with psoriasis, rheumatoid arthritis, and inflammatory bowel disease...
  22. MATRIX MEDIATORS OF WOUND HEALING
    Paul J Higgins; Fiscal Year: 2010
    ..g., arthritis, psoriasis, cancer, cardiovascular and pulmonary fibrosis, diabetic retinopathy, macular degeneration, excessive scaring ..
  23. Molecular Basis of the Anti-inflammatory Action of MAYP/PSTPIP2
    Violeta Chitu; Fiscal Year: 2012
    ..to an understanding of the molecular mechanisms involved in skin inflammation and joint and bone destruction in psoriasis, arthritis and related autoinflammatory disorders...
  24. Role of ROR??t in the transcriptional regulatory network underlying Th17 lineage
    Dan Littman; Fiscal Year: 2010
    ..pathogenesis, including inflammatory bowel diseases, rheumatoid arthritis, multiple sclerosis, diabetes, psoriasis, and asthma...
  25. Collider Bias and the Risk Factor Paradoxes in Rheumatic Disease Research
    UYEN SA DUC TRAN NGUYEN; Fiscal Year: 2013
    ..3 key rheumatic disease contexts (smoking and risk of CV events in RA;smoking and risk of psoriatic arthritis in psoriasis;and obesity and risk of disease progression i knee OA)...
  26. Anti-Inflammatory Interventions in Maintenance Hemodialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2013
    ..specific anti-cytokin therapies have been used successfully to treat patients with inflammatory bowel disease, psoriasis and rheumatoid arthritis, and while encouraging studies have been reported in improving glycemic control and ..
  27. CD1 presentation of self glycolipids and lipopeptides to T cells
    DAVID BRANCH MOODY; Fiscal Year: 2013
    ..of self glycolipids and lipopeptides to T cells T cells that recognize autoantigens play a central role in psoriasis, thyroiditis, diabetes, multiple sclerosis, rheumatoid arthritis and other human autoimmune diseases...
  28. TNIP1 risk haplotypes and immune endophenotypes
    Peter K Gregersen; Fiscal Year: 2013
    ..with a variety of autoimmune diseases, including systemic lupus erythematosus (SLE), systemic sclerosis, and psoriasis, and more recently rheumatoid arthritis...
  29. Protein Kinase D and Epidermal Structure and Function
    Wendy B Bollag; Fiscal Year: 2010
    ..demonstrated that PKD is up-regulated in human BCCs and mislocalized in the hyper-proliferative skin disorder psoriasis. Recently, we have also obtained data to support the idea that PKD is activated upon exposure of keratinocytes ..
  30. Trim32 Regulation of Piasy in Skin Homeostasis
    Molly F Kulesz-Martin; Fiscal Year: 2013
    PROJECT SUMMARY There is a vicious circle in psoriasis that disrupts epidermal homeostasis through alterations in keratinocytes (hyperproliferation, parakeratosis) and immunocytes (infiltration and activation)...
  31. Identification of Psoriatic Arthritis Genes
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..Genetic factors play an important role in psoriatic arthritis (PsA), and both PsA and purely cutaneous psoriasis (PsC) display strong HLA associations...
  32. Ligand independent signaling by VDR in Keratinocytes
    Paul N MacDonald; Fiscal Year: 2010
    ..In fact, VDR is a clinically relevant target for the use of 1,25(OH)2D3 analogs in the treatment of psoriasis, a hyperproliferative disorder of the skin...
  33. Regulation of human skin homeostasis by histone arginine methylation regulators
    Xiaomin Bao; Fiscal Year: 2013
    ..provided by applicant): Epidermal homeostasis is disrupted in a host of human skin diseases, including psoriasis, chronic wounds, and cancer...
  34. Comparative Effectiveness of Biologics for Psoriasis
    Joel M Gelfand; Fiscal Year: 2010
    ..in Autoimmune Rheumatic and Skin Diseases Title of application: Comparative Effectiveness of Biologics for Psoriasis Psoriasis is a chronic, inflammatory Th-1, Th-17 mediated disease that affects over 7 million Americans...
  35. Keratins, Wound Reepithelialization, and Hair Follicle Cycling
    PIERRE COULOMBE; Fiscal Year: 2013
    ..Our central dogma is that such functions are highly relevant to the pathogenesis of chronic diseases such as psoriasis and carcinoma...
  36. Origin and Function of Inflammatory Dendritic Cells in Psoriasis.
    Michelle A Lowes; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Great progress has been made treating psoriasis over the last 10 years, predominantly using T cell-targeted therapies...
  37. Targeted Delivery of a Novel Synthetic Curcumin Analog, EF24 to Glioblastoma and
    MAMORU NONE SHOJI; Fiscal Year: 2012
    ..the abnormal vessels in GBM, the approach may find application in other diseases with abnormal blood vessel growth, such as diabetic retinopathy, macular degeneration, endometriosis, Crohn's disease, psoriasis, and other cancers.
  38. Effects of Artemin on Nociceptors
    KATHRYN MARIE ALBERS; Fiscal Year: 2013
    ..acetylcholine, glutamate and peptides is commonly elevated in inflammatory diseases such as pancreatitis, psoriasis, rheumatoid arthritis and cystitis...
  39. Function and Targeting of CCR6/CCL20 in Autoimmune Psoriasiform Skin Disease
    Sam T Hwang; Fiscal Year: 2013
    ..in the development of multiple autoimmune processes, including rheumatoid arthritis, multiple sclerosis, and psoriasis. IL23 is a prototypical driver of Th17-mediated inflammation, and we and others have shown that repeated ..
  40. Epha/Ephrin - A Signaling in Epidermal Differentiation and Disease
    Spiro Getsios; Fiscal Year: 2013
    ..applicant): Epidermal differentiation is essential for survival and impaired in common skin diseases, including psoriasis. Keratinocytes interact and communicate with their neighbors via cell surface proteins;this helps determine ..
  41. Remote Inflammation and Atherothrombosis
    NICOLE LEANNE WARD; Fiscal Year: 2013
    ..will provide insight into the etiology and development of novel therapies directed towards CVD co-morbidities associated with chronic inflammatory diseases including rheumatoid arthritis, colitis, gum disease, psoriasis and lupus.
  42. LINKAGE ANALYSIS OF FAMILIAL PSORIASIS
    JAMES TILFORD ELDER; Fiscal Year: 2013
    b>Psoriasis is a common, immunologically-mediated, inflammatory and hyperproliferative disease of the skin and joints, with a multifactorial genetic basis...
  43. Anti-inflammatory promoting commensal E. coli
    CAMMIE LESSER; Fiscal Year: 2013
    ..immune system is linked to many inflammatory autoimmune-based diseases, including inflammatory bowel disease, psoriasis and rheumatoid arthritis...
  44. Identification of Alopecia Areata Biomarkers in Skin and Blood
    Angela M Christiano; Fiscal Year: 2012
    ..of risk loci shared by rheumatoid arthritis (RA), type 1 diabetes (T1D), celiac disease (CeD), SLE, MS and psoriasis (PS)...
  45. The Role of Gut and Skin Microbiome in Psoriatic Arthritis
    Jose U Scher; Fiscal Year: 2013
    ..PsA) is a chronic inflammatory disease of unknown etiolology, occurring in about one third of people with psoriasis of the skin (a condition that affects 2-3% of the population)...
  46. Short Wavelength UV Sources for Treatment of Psoriasis
    JOSEPH SMART; Fiscal Year: 2006
    ..of ultraviolet (UV) light emitting diodes (LEDs) in the emission range of 305 nm to 315 nm for phototherapy of psoriasis. Successful production of UV sources in this wavelength range will enable research for new phototherapy ..
  47. Genetic and Genomic Dissection of Psoriatic Arthritis
    JAMES TILFORD ELDER; Fiscal Year: 2013
    ..amongst the inflammatory/autoimmune joint diseases in that its onset is commonly preceded by cutaneous psoriasis (PsC)...
  48. STAT3 Structural Determinants
    Nancy C Reich; Fiscal Year: 2012
    ..of autoimmune diseases such as multiple sclerosis, inflammatory bowel disease, systemic lupus erythematosus, psoriasis, and rheumatoid arthritis...
  49. Transcriptional Co-Regulatiors in Epidermis
    Bogi Andersen; Fiscal Year: 2013
    ..to explore Grhl3's barrier repair function and tests whether the Grhl3 regulatory network is defective in psoriasis. This work is highly significant because it reveals fundamental mechanisms in gene regulation as a cell switches ..
  50. The role of interleukin 22 in West Nile virus pathogenesis in mice
    Penghua Wang; Fiscal Year: 2013
    ..On one hand, IL-22 contributes to pathogenesis of psoriasis and multiple sclerosis...
  51. Elucidation of the transcriptional network underlying the Th17 lineage program
    Dan Littman; Fiscal Year: 2013
    ..there is accumulating evidence that these cells have key roles in human diseases such as Crohn's disease, psoriasis, and rheumatoid arthritis...
  52. Systems Biology of Psoriasis
    Weixiong Zhang; Fiscal Year: 2010
    ..b>Psoriasis (PS) is a complex inflammatory skin disease where genetic risk factors and environmental trigger contribute to ..
  53. Structure-Function Relationships in the IL-17 Receptor
    Sarah L Gaffen; Fiscal Year: 2012
    ..be responsible for causing many of the pathological effects of autoimmune diseases such as rheumatoid arthritis, psoriasis, systemic lupus erythematosis (SLE) and Crohn's disease...
  54. Mechanisms of sensory neuron control over skin immune responses
    JOSE MANUEL ORDOVAS-MONTANES; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psoriasis and other pathological skin diseases have typically been considered as immune-driven diseases...
  55. A trial to determine the effect of psoriasis treatment on cardiometabolic disease
    Joel M Gelfand; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psoriasis affects over 7 million people in the US (125 million people worldwide) and is the most common helper T-cell (Th)-1, Th-17 mediated inflammatory disease in humans...
  56. Innate Mechanisms Regulating CD8+ T Cell Immunity
    ROBERT LESLIE FAIRCHILD; Fiscal Year: 2010
    Many cutaneous immune responses, such as those in response to melanoma and psoriasis, are mediated by CD8+ T cells. The factors directing recruitment of CD8+ T cells specific for antigens deposited in the skin remain unclear...
  57. Defensin gene copy number and mucosal innate immunity
    JAY V contact SOLNICK; Fiscal Year: 2010
    ..increases the risk for Crohn's disease of the colon, while high GCN is associated with increased risk of psoriasis. We recently used the rhesus macaque model to demonstrate that, like in humans, BD2 expression is induced by ..
  58. Genetic Architecture of Rheumatoid Arthritis in African-Americans
    MARIA IOANA DANILA; Fiscal Year: 2013
    ..diabetes, lupus, celiac disease, autoimmune thyroid disease, inflammatory bowel disease, ankylosing spondylitis, psoriasis and other diseases. Genotyping is currently underway (see letter from Dr...
  59. Functional Genomics of Psoriasis
    JAMES TILFORD ELDER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Recent genome-wide association studies (GWAS) of psoriasis have identified 41 psoriasis susceptibility loci, and we are currently applying multiple genetic and genomic assets to the molecular genetic ..
  60. T-cell immunity to polyomavirus infection
    ARON LUKACHER; Fiscal Year: 2013
    ..g., multiple sclerosis, Crohn's disease, and severe psoriasis)...
  61. Online patient self-assessment system for care and research of joint and skin dis
    Andrew H Soll; Fiscal Year: 2012
    ..For Phase 1 we focus on psoriasis (Ps) and psoriatic arthritis (PsA), which present challenging BPSB issues...
  62. Proteolysis and Skin Antimicrobials
    Richard L Gallo; Fiscal Year: 2013
    ..Control of this processing is relevant to skin diseases ie. rosacea and psoriasis. Additional processing by microbial proteases serves as a virulence mechanism to alter normal host immunity...
  63. Development of Topical Neuroinflammatory Inhibitors
    MANDIP SACHDEVA; Fiscal Year: 2005
    ..Certain skin diseases such as psoriasis, contact dermatitis and atopic dermatitis may have a significant neurogenic component...
  64. Nanospheres as Delivery Vehicles for Psoriasis Therapeutics
    LARISA contact SHEIHET; Fiscal Year: 2010
    ..of the barriers to efficient topical delivery and promote the design of a formulation for the delivery of psoriasis therapeutics...
  65. PHOSPHOLIPASE C/PROTEIN KINASE C IN PSORIATIC EPIDERMIS
    Gary Fisher; Fiscal Year: 1993
    ..b>Psoriasis is a common dermatological disease that affects 1- 2% of the American population...
  66. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..of physiological agents in this distribution, (iii) interaction with target proteins, and (iv) alteration in psoriasis. In preparation for these studies they have cloned cDNAs, expressed protein, and produced antibodies against ..
  67. C/EDB BETA AND CHOP IN EPIDERMAL DIFFERENTIATION
    Edward Maytin; Fiscal Year: 2002
    ..Derangements in epidermal function in diseases such as psoriasis, or in environmental injuries such as exposure to ultraviolet light, result from abnormalities in the precise ..
  68. Genotyping the NPF Biobank for Psoriasis Susceptibility Genes
    JAMES TILFORD ELDER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Genotyping the NPF Biobank for Psoriasis Susceptibility Genes This application addresses broad Challenge Area (08) Genomics and Specific Challenge Area: 08-AR-101 Genotyping of Existing Cohorts in ..
  69. PML antiviral for AIDS
    Milton H Werner; Fiscal Year: 2010
    ..occurs in a wide variety of patients, has forced such benchmark drugs as Tysabri (for MS) and Raptiva (for psoriasis) off the market due to the sporadic occurrence of the disease, Inhibikase has the opportunity to help a very ..
  70. Kaiser Permanente Autoimmune Disease Registry
    Lisa J Herrinton; Fiscal Year: 2010
    ..on five diseases: rheumatoid arthritis (RA), juvenile inflammatory arthritis (JIA), psoriatic arthritis (PsA), psoriasis (PsO), and ankylosing spondylitis (AS)...