Genomes and Genes
Summary: A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).
Publications323 found, 100 shown here
- Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveysM Innes Asher
Department of Paediatrics, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1010, New Zealand
Lancet 368:733-43. 2006Data for trends in prevalence of asthma, allergic rhinoconjunctivitis, and eczema over time are scarce...
- Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infantsM J Gosalbes
Unidad Mixta de Investigación en Genómica y Salud Centro Superior de Investigación en Salud Pública Generalitat Valenciana, Institut Cavanilles de Biodiversitat i Biologia Evolutiva Universitat de València, Valencia, Spain
Clin Exp Allergy 43:198-211. 2013....
- Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infantsY Miyake
Dept of Public Health Faculty of Medicine, Fukuoka University, Fukuoka, Japan
Eur Respir J 35:1228-34. 2010..between maternal consumption of dairy products, calcium, and vitamin D during pregnancy and the risk of wheeze and eczema in the infants aged 16-24 months. Subjects were 763 Japanese mother-child pairs...
- Prenatal exposure to butylbenzyl phthalate and early eczema in an urban cohortAllan C Just
Columbia Center for Children s Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 120:1475-80. 2012Recent cross-sectional studies suggest a link between butylbenzyl phthalate (BBzP) in house dust and childhood eczema.
- Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the INMA studyInmaculada Aguilera
Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
Environ Health Perspect 121:387-92. 2013..Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health...
- Global variations in prevalence of eczema symptoms in children from ISAAC Phase ThreeJoseph A Odhiambo
Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya
J Allergy Clin Immunol 124:1251-8.e23. 2009In 1999, The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One reported the prevalence of eczema symptoms in 715,033 children from 154 centers in 56 countries by using standardized epidemiologic tools.
- Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of ageC Flohr
Department of Children s Allergies, MRC Asthma UK Centre in Allergic Mechanisms of Asthma, King s College London, London, UK
Br J Dermatol 163:1333-6. 2010Filaggrin loss-of-function (FLG) mutations are associated with eczema and skin barrier impairment, but it is unclear whether skin barrier impairment precedes phenotypic eczema in FLG mutation carriers.
- The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort studyJohn Henderson
Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom
J Allergy Clin Immunol 121:872-7.e9. 2008Atopic disease is a major health problem. Mutations in the filaggrin gene (FLG) confer major susceptibility to eczema and related asthma.
- Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic diseaseElke Rodriguez
Division of Environmental Dermatology and Allergy, Helmholtz Zentrum Munich and ZAUM Center for Allergy and Environment, Technische Universitat Munchen, Munich, Germany
J Allergy Clin Immunol 123:1361-70.e7. 2009The discovery of filaggrin (FLG) null mutations as a major risk factor for eczema represents a milestone toward the understanding of an important mechanism in this complex disease...
- Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programmeRichard Beasley
Medical Research Institute of New Zealand, Wellington, New Zealand
Lancet 372:1039-48. 2008..We studied 6-7-year-old children from Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) programme to investigate the association between paracetamol consumption and asthma...
- Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase ThreeRichard W Beasley
Medical Research Institute of New Zealand, Private Bag 7902, Wellington 6242, New Zealand
Am J Respir Crit Care Med 183:171-8. 2011..There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma...
- Eczema prevalence in the United States: data from the 2003 National Survey of Children's HealthTatyana E Shaw
Department of Dermatology, Oregon Health and Science University, Portland, Oregon, USA
J Invest Dermatol 131:67-73. 2011..Children's Health sponsored by the federal Maternal and Child Health Bureau, we calculated prevalence estimates of eczema nationally and for each state among a nationally representative sample of 102,353 children 17 years of age and ..
- A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trialKristin Wickens
Wellington Asthma Research Group, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
J Allergy Clin Immunol 122:788-94. 2008The role of probiotics in prevention of allergic disease is still not clearly established, although early reports suggested Lactobacillus GG halved the risk of eczema at 2 years.
- The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort studyAlemayehu Amberbir
School of Public Health, Addis Ababa University, PO Box 80596, Addis Ababa, Ethiopia
Am J Respir Crit Care Med 183:165-70. 2011..Acetaminophen has been hypothesized to increase the risk of asthma and allergic disease, and geohelminth infection to reduce the risk, but evidence from longitudinal cohort studies is lacking...
- Is there a rural/urban gradient in the prevalence of eczema? A systematic reviewM E Schram
Department of Dermatology, A0 252, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DD Amsterdam, The Netherlands
Br J Dermatol 162:964-73. 2010b>Eczema affects approximately 10% of all schoolchildren in the western world and has shown an increase over the past decades in 'developing' countries...
- The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality?K Wickens
Wellington Asthma Research Group, Department of Medicine, University of Otago, Wellington, New Zealand
Clin Exp Allergy 38:1318-24. 2008..In general, studies reporting positive associations between antibiotic exposure and respiratory and allergic disease have been unable to determine the nature of this association...
- Probiotics during weaning reduce the incidence of eczemaChristina E West
Department of Clinical Sciences, Pediatrics, Umea University, Umeå S 901 85, Sweden
Pediatr Allergy Immunol 20:430-7. 2009..Some studies have indicated that probiotics may be effective in the prevention of eczema. In vitro studies indicate that probiotics have immunomodulatory effects...
- Development and comorbidity of eczema, asthma and rhinitis to age 12: data from the BAMSE birth cohortN Ballardini
Institute of Environmental Medicine, Karolinska Institutet, Stockholm
Allergy 67:537-44. 2012..The aim was to study the development of eczema, asthma and rhinitis in relation to sex and parental allergy, in a population-based cohort, during childhood.
- The association between tobacco and the risk of asthma, rhinoconjunctivitis and eczema in children and adolescents: analyses from Phase Three of the ISAAC programmeEdwin A Mitchell
Department of Paediatrics Child and Youth Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Thorax 67:941-9. 2012..Exposure to parental smoking is associated with wheeze in early childhood, but in 2006 the US Surgeon General stated that the evidence is insufficient to infer a causal relationship between exposure and asthma in childhood and adolescents...
- ETFAD/EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitisU Darsow
Department of Dermatology and Allergy Biederstein, Technische Universitat Munchen
J Eur Acad Dermatol Venereol 24:317-28. 2010..The diagnosis of atopic dermatitis (AD) is made using evaluated clinical criteria. Management of AD must consider the symptomatic variability of the disease...
- Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trialJuliet Ndibazza
Medical Research Council Uganda Virus Research Institute Uganda Research Unit on AIDS, Entebbe, Uganda
PLoS ONE 7:e50325. 2012..We addressed the hypothesis that anthelminthic treatment in pregnancy and early childhood would improve responses to immunisation and modulate disease incidence in early childhood with both beneficial and detrimental effects...
- Impact of early feeding on childhood eczema: development after nutritional intervention compared with the natural course - the GINIplus study up to the age of 6 yearsA V Berg
Marien Hospital Wesel, Department of Paediatrics, Germany
Clin Exp Allergy 40:627-36. 2010Nutritional intervention with hydrolysed infant formulas has been shown efficacious in preventing eczema in children predisposed to allergy...
- Is eczema really on the increase worldwide?Hywel Williams
Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, United Kingdom
J Allergy Clin Immunol 121:947-54.e15. 2008It is unclear whether eczema prevalence is truly increasing worldwide.
- Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposureM L A Schuttelaar
Departments of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Allergy 64:1758-65. 2009Filaggrin gene (FLG) mutations contribute to the development of eczema and asthma, but their contribution to sensitization and hay fever remains unclear.
- Clinical severity correlates with impaired barrier in filaggrin-related eczemaIkue Nemoto-Hasebe
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
J Invest Dermatol 129:682-9. 2009..involved in skin barrier function, have been shown to be a major predisposing factor for atopic dermatitis (AD; eczema)...
- Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in VietnamC Flohr
Centre for Population Studies, Institute of Clinical Research, University of Nottingham, Nottingham, UK
Clin Exp Allergy 40:131-42. 2010..Observational evidence suggests that infection with helminths protects against allergic disease and allergen skin sensitization. It is postulated that such effects are mediated by helminth-induced cytokine responses, in particular IL-10...
- Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trialMarko Kalliomaki
J Allergy Clin Immunol 119:1019-21. 2007
- Low diversity of the gut microbiota in infants with atopic eczemaThomas R Abrahamsson
Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden
J Allergy Clin Immunol 129:434-40, 440.e1-2. 2012..The advent of powerful, cultivation-free molecular methods makes it possible to characterize the total microbiome down to the genus level in large cohorts...
- Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infantsY Miyake
Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka
Allergy 65:758-65. 2010..We investigated the association between maternal intake of vegetables, fruit, and selected antioxidants during pregnancy and the risk of wheeze and eczema in the offspring aged 16-24 months.
- Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildrenGabriele Nagel
Institute of Epidemiology, Ulm University, Ulm, Germany
Pediatr Allergy Immunol 20:81-8. 2009..23; 95% CI: 1.28-7.76) and ever-diagnosed eczema (OR: 2.35; 95% CI: 1.13-4.89)...
- The effects of selected probiotic strains on the development of eczema (the PandA study)L Niers
Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
Allergy 64:1349-58. 2009..We aimed to study primary prevention of allergic disease in high-risk children by pre- and postnatal supplementation of selected probiotic bacteria...
- Comparative analysis of fecal microbiota in infants with and without eczemaPei Ying Hong
Division of Environmental Science and Engineering, National University of Singapore, Singapore
PLoS ONE 5:e9964. 2010b>Eczema is a chronic form of childhood disorder that is gaining in prevalence in affluent societies...
- Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) Phase ThreeN Ait-Khaled
International Union Against Tuberculosis and Lung Disease, Paris, France
Allergy 64:123-48. 2009..Phase One of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global patterns of prevalence and severity of symptoms of rhinoconjunctivitis in children in 1993-1997...
- Skin barrier function, epidermal proliferation and differentiation in eczemaEhrhardt Proksch
Department of Dermatology, University of Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
J Dermatol Sci 43:159-69. 2006Skin permeability barrier function is impaired in eczema, particularly in contact and atopic dermatitis (AD)...
- Pre- and post-natal exposure to antibiotics and the development of eczema, recurrent wheezing and atopic sensitization in children up to the age of 4 yearsS Dom
Department of Epidemiology and Social Medicine, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium
Clin Exp Allergy 40:1378-87. 2010..On the other hand, several studies have been conducted on the association with direct post-natal antibiotic exposure, but the results are conflicting...
- Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase OneM Innes Asher
Department of Paediatrics, Child and Youth Health, The University of Auckland, Auckland, New Zealand
Respir Res 11:8. 2010..Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold between countries...
- Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of lifePeter Rzehak
Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
PLoS ONE 5:e13261. 2010..We analyze this genetic-association in two children-cohort-studies. In addition, the association between variants in the FADS-gene-cluster and blood-fatty-acid-composition with eczema was studied.
- The 2002-2007 trends of prevalence of asthma, allergic rhinitis and eczema in Irish schoolchildrenEileen M Duggan
Department of Paediatrics and Child Health, University College Cork, Cork, Ireland
Pediatr Allergy Immunol 23:464-71. 2012..Few data examine trends of prevalence of asthma and allergic disorders in younger Irish children. We compared the prevalence of asthma, allergic rhinitis and eczema in school children, aged 6-9 in 2002 and 2007.
- The Self-administered Eczema Area and Severity Index in children with moderate to severe atopic dermatitis: better estimation of AD body surface area than severitySara G A Van Velsen
Department of Pediatric Dermatology Allergology, Wilhelmina s Children Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
Pediatr Dermatol 27:470-5. 2010The Self-Administered Eczema Area and Severity Index (SA-EASI) is one of the few patient based atopic dermatitis (AD) disease activity scores and was found to be highly correlated with the EASI...
- Validation of asthma and eczema in population-based Swedish drug and patient registersAnne K Ortqvist
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Pharmacoepidemiol Drug Saf 22:850-60. 2013Validated measures of asthma and eczema at the population level remain a challenge...
- A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 yearsK Wickens
Wellington Asthma Research Group, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
Clin Exp Allergy 42:1071-9. 2012..until 2 years with Lactobacillus rhamnosus HN001 (HN001) (6 × 10(9) cfu/day) halved the cumulative prevalence of eczema by age 2 years. Bifidobacterium animalis subsp lactis HN019 (HN019) (9 × 10(9) cfu/day) had no effect.
- Early life exposure to farm animals and symptoms of asthma, rhinoconjunctivitis and eczema: an ISAAC Phase Three StudyBert Brunekreef
Institute for Risk Assessment Sciences and Julius Center for Health Sciences and Primary Care, University Medical Center Universiteit Utrecht, Utrecht, The Netherlands
Int J Epidemiol 41:753-61. 2012..Associations between early life exposure to farm animals and respiratory symptoms and allergy in children have been reported in developed countries, but little is known about such associations in developing countries...
- Reduced gut microbial diversity in early life is associated with later development of eczema but not atopy in high-risk infantsIntan H Ismail
Allergy and Immune Disorders, Murdoch Children s Research Institute, Melbourne VIC, Australia
Pediatr Allergy Immunol 23:674-81. 2012..Recent studies suggest that healthy infant immune development may depend on the establishment of a diverse gut microbiota rather than the presence or absence of specific microbial strains...
- Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczemaK Laitinen
Department of Paediatrics, Turku University Central Hospital, Turku, Finland
Clin Exp Allergy 36:166-73. 2006..The major theory implicating diet with allergic diseases is associated with altered food consumption and subsequent changes in fatty acid composition...
- Prevention of asthma during the first 5 years of life: a randomized controlled trialGuy B Marks
Woolcock Institute of Medical Research, Missenden Road Post Office, New South Wales 2050, Australia
J Allergy Clin Immunol 118:53-61. 2006..Early life exposures may be important in the development of asthma and allergic disease...
- Prevalence of hand eczema in an adult Swedish population and the relationship to risk occupation and smokingPeter Montnemery
Department of Community Medicine Division of Geriatric Medicine, Lund University and Respiratory Medicine, Lund University Hospital, Sweden
Acta Derm Venereol 85:429-32. 2005Using a postal questionnaire the prevalence of hand eczema was determined in a general population of 11,798 individuals aged 20-77 years who were randomly drawn from the population records. The response rate was 78.1%...
- Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort studyPhilip J Cooper
Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
BMC Infect Dis 11:184. 2011....
- The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay feverIngo Marenholz
Pediatric Pneumology and Immunology, Charite University Medicine Berlin, 13353 Berlin, Germany
Hum Mol Genet 20:2443-9. 2011..5 (rs7927894[T]) has been identified as a susceptibility locus for eczema. We aimed to analyze the effect of this risk variant on asthma and hay fever and to determine its impact on the ..
- Severe, generalized nummular eczema secondary to interferon alfa-2b plus ribavirin combination therapy in a patient with chronic hepatitis C virus infectionMegan M Moore
Harvard Medical School, Boston, Massachusetts, USA
Arch Dermatol 140:215-7. 2004..There are few previous case reports of generalized eczematous dermatoses occurring after combination therapy for hepatitis C virus, none in a North American patient, and none of this severity or recalcitrance...
- Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivityP Endara
Colegio de Ciencias de la Salud, Universidad San Francisco de Quito, Quito, Ecuador
Clin Exp Allergy 40:1669-77. 2010..There is concern that treatment-based control programmes for these parasites may lead to an increase in the prevalence of allergic diseases...
- Fertility rates in women with asthma, eczema, and hay fever: a general population-based cohort studyL J Tata
Division of Epidemiology and Public Health, School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom
Am J Epidemiol 165:1023-30. 2007..In this study, the authors compared fertility rates among women with asthma, eczema, or hay fever with those in the general female population...
- Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase IIISunia Foliaki
Center for Public Health Research, Massey University, Wellington, New Zealand
J Allergy Clin Immunol 124:982-9. 2009Phase III of the International Study of Asthma and Allergies in Childhood measured the global prevalence of symptoms of asthma, rhinoconjunctivitis, and eczema in children.
- Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort studyS H Arshad
David Hide Asthma and Allergy Research Centre, St Mary s Hospital, Newport, Isle of Wight, United Kingdom
Pediatrics 108:E33. 2001..Although it is generally agreed that atopy is an important risk factor for allergic diseases such as asthma, rhinitis, and eczema, the extent to which atopy accounts for these diseases is controversial.
- A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2J Genuneit
Institute of Epidemiology, Ulm University, Ulm, Germany
Clin Exp Allergy 39:1875-88. 2009..We investigated their associations with wheeze and allergy in a case-control sample from Phase 2 of the International Study of Asthma and Allergies in Childhood...
- The epidemiology of hand eczema in the general population--prevalence and main findingsJacob P Thyssen
National Allergy Research Centre, Department of Dermato Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
Contact Dermatitis 62:75-87. 2010Numerous studies have investigated the prevalence and risk factors of hand eczema in the general population...
- Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of lifeSheelagh Martindale
Department of Environmental and Occupational Medicine, University of Aberdeen, Aberdeen, Scotland, United Kingdom
Am J Respir Crit Care Med 171:121-8. 2005..investigation of the influence of maternal antioxidant intake in pregnancy on the development of asthma and eczema in children...
- Lactobacillus GG treatment during pregnancy for the prevention of eczema: a randomized controlled trialR J Boyle
Allergy and Immune Disorders, Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
Allergy 66:509-16. 2011Probiotic supplementation in early life may be effective for preventing eczema. Previous studies have suggested that prenatal administration may be particularly important for beneficial effects.
- Do early intake of fish and fish oil protect against eczema and doctor-diagnosed asthma at 2 years of age? A cohort studyTorbjørn Oien
Department of Public Health and General Practice, Norwegian University of Science and Technology, Medisinsk Teknisk Forskningssenter MTFS, 7489 Trondheim, Norway
J Epidemiol Community Health 64:124-9. 2010..The aim was to investigate the association between cod liver oil and fish consumption during pregnancy and in the first year of life and asthma and eczema at 2 years of age.
- Risk analysis of early childhood eczemaHans Bisgaard
Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark
J Allergy Clin Immunol 123:1355-60.e5. 2009The increasing prevalence of eczema suggests the role of environmental factors triggering a genetic predisposition.
- Hand eczema severity and quality of life: a cross-sectional, multicentre study of hand eczema patientsTove Agner
Department of Dermatology, Roskilde Hospital, University of Copenhagen, 4000 Roskilde, Denmark
Contact Dermatitis 59:43-7. 2008Hand eczema is a chronic disease with negative impact on quality of life (QoL). In this study, QoL in hand eczema patients is assessed and related to age, sex, severity, and diagnostic subgroups.
- An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthmaIngo Marenholz
Max Delbrück Centrum MDC for Molecular Medicine, Berlin, Germany
J Allergy Clin Immunol 123:911-6. 2009Asthma prediction in early infancy is essential for the development of new preventive strategies. Loss-of-function mutations in the filaggrin gene (FLG) were identified as risk factors for eczema and associated asthma.
- Childhood eczema and asthma incidence and persistence: a cohort study from childhood to middle ageJohn A Burgess
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Australia
J Allergy Clin Immunol 122:280-5. 2008The association between eczema and asthma is well documented, but the temporal sequence of this association has not been closely examined.
- Effect of probiotic mix (Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trialJi Yeun Kim
Department of Food and Nutrition, College of Human Ecology, Seoul National University, San 56 1, Shinlimdong, Kwanakku, Seoul, Korea
Pediatr Allergy Immunol 21:e386-93. 2010Controversy exists regarding the preventive effect of probiotics on the development of eczema or atopic dermatitis. We investigated whether supplementation of probiotics prevents the development of eczema in infants at high risk...
- Prevalences of symptoms of asthma and other allergic diseases in korean children: a nationwide questionnaire surveyS I Lee
Department of Pediatrics, Sungkyunkwan University School of Medicine, Suwon, Korea
J Korean Med Sci 16:155-64. 2001..Twelve-month prevalences of the symptoms of asthma, rhinoconjunctivitis, and flexural eczema were 8.7%, 10.5%, 7.3% in 6-12 yr olds, and 8.2%, 10.0%, 3.9% in 12-15 yr olds, respectively...
- Probiotic supplementation in the first 6 months of life in at risk Asian infants--effects on eczema and atopic sensitization at the age of 1 yearS E Soh
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and National University Hospital, Singapore
Clin Exp Allergy 39:571-8. 2009The role of probiotics in allergy prevention remains uncertain but has been shown in some studies to have a possible protective effect on eczema.
- Early fish introduction is associated with less eczema, but not sensitization, in infantsB Hesselmar
Department of Paediatrics, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Acta Paediatr 99:1861-7. 2010..To investigate if the development of allergic diseases during the child's first 18 months of life is influenced by the time at which different food items were introduced into the child's diet...
- Filaggrin null mutations and childhood atopic eczema: a population-based case-control studySara J Brown
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
J Allergy Clin Immunol 121:940-46.e3. 2008Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown.
- Eczema vaccinatumJennifer L Reed
Laboratory of Plasma Derivatives, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20892, USA
Clin Infect Dis 54:832-40. 2012b>Eczema vaccinatum (EV) is a complication of smallpox vaccination that can occur in persons with eczema/atopic dermatitis (AD), in which vaccinia virus disseminates to cause an extensive rash and systemic illness...
- Prevalence and risk factors of wheeze and eczema in 1-year-old children: the Butajira birth cohort, EthiopiaY Belyhun
Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Ethiopia
Clin Exp Allergy 40:619-26. 2010..The rising global prevalence of asthma and other allergic conditions has been linked to potential aetiological factors influencing the developing immune system...
- Atopic and non-atopic eczemaSara Brown
Department of Dermatology, Royal Victoria Infirmary, and Dermatological Sciences, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
BMJ 332:584-8. 2006
- Eczema among adults: prevalence, risk factors and relation to airway diseases. Results from a large-scale population survey in SwedenE P Rönmark
Krefting Research Centre, Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 424, SE 405 30 Gothenburg, Sweden
Br J Dermatol 166:1301-8. 2012In contrast to asthma and rhinitis, few studies among adults investigating the prevalence and risk factors of eczema have been published.
- The patient-oriented eczema measure: development and initial validation of a new tool for measuring atopic eczema severity from the patients' perspectiveCarolyn R Charman
Department of Dermatology, Queen s Medical Centre, Nottingham, England
Arch Dermatol 140:1513-9. 2004To develop a simple, valid, repeatable, and readily understandable patient-oriented assessment measure for monitoring disease activity in children and adults with atopic eczema.
- Household conditions, eczema symptoms and rhinitis symptoms: relationship with wheeze and severe wheeze in children living in the Polokwane area, South AfricaJanine Wichmann
School of Health Systems and Public Health, Health Sciences Faculty, University of Pretoria, P O Box 667, Pretoria, 0001, South Africa
Matern Child Health J 13:107-18. 2009..Objective To assess the 12-month prevalence of wheeze and severe wheeze along with their potential risk factors. Setting Within a 60-km radius from the Polokwane city centre, Limpopo Province...
- Hands4U: a multifaceted strategy to implement guideline-based recommendations to prevent hand eczema in health care workers: design of a randomised controlled trial and (cost) effectiveness evaluationEsther W C van der Meer
Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
BMC Public Health 11:669. 2011Workers in wet work occupations have a risk for developing hand eczema. Prevention strategies exist, but compliance to the proposed recommendations is poor...
- Steroid fears in children with eczemaKam Lun Ellis Hon
Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Acta Paediatr 95:1451-5. 2006Topical glucocorticoids (GCs) are the mainstay of treatment for eczema, but GC phobia and fears are very common among the parents of paediatric patients.
- Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczemaRoger B Newson
Department of Public Health Sciences, Guy s, King s and St Thomas School of Medicine, King s College, London, UK
J Allergy Clin Immunol 114:531-7. 2004..Few studies have explored whether fetal exposure to n-6 and n-3 fatty acids influences the inception of atopic disease...
- High circulating immunoglobulin A levels in infants are associated with intestinal toxigenic Staphylococcus aureus and a lower frequency of eczemaA C Lundell
Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
Clin Exp Allergy 39:662-70. 2009..Intestinal bacteria trigger IgA production and delayed maturation of mucosal IgA response is linked to allergy development...
- Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohortLaura B von Kobyletzki
Department of Dermatology, Institute of Clinical Research in Malmö, Skane University Hospital, Lund University, Malmo, Sweden
BMC Dermatol 12:11. 2012This study aimed to estimate the association between eczema in early childhood and the onset of asthma and rhinitis later in life in children.
- Maternal fish consumption during pregnancy and risks of wheezing and eczema in childhood: the Generation R StudyE T M Leermakers
The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
Eur J Clin Nutr 67:353-9. 2013..In Generation R, a prospective cohort study in the Netherlands, we examined the associations of first trimester fish consumption with childhood wheezing and eczema in the first 4 years of life.
- Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also reduce atopic sensitization?K Wickens
Wellington Asthma Research Group, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
Clin Exp Allergy 43:1048-57. 2013..until 2 years with Lactobacillus rhamnosus HN001 (HN001) (6 × 10(9) cfu/day) halved the cumulative prevalence of eczema at 2 and 4 years...
- The association between BMI, vigorous physical activity and television viewing and the risk of symptoms of asthma, rhinoconjunctivitis and eczema in children and adolescents: ISAAC Phase ThreeE A Mitchell
Department of Paediatrics Child and Youth Health, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
Clin Exp Allergy 43:73-84. 2013Several studies have observed an association between obesity and asthma, but whether or not there is an association with rhinoconjunctivitis or eczema is unclear.
- Probiotics and prebiotics in preventing food allergy and eczemaMikael Kuitunen
Helsinki University Central Hospital, Children s Hospital, Helsinki, Finland
Curr Opin Allergy Clin Immunol 13:280-6. 2013To describe the current literature on clinical trials of probiotics for eczema and food allergy prevention in view of recent new approaches and long-term follow-ups.
- Alitretinoin for severe chronic hand eczema: a NICE single technology appraisalMark Rodgers
Centre for Reviews and Dissemination, University of York, Heslington, York, UK
Pharmacoeconomics 28:351-62. 2010..for the clinical and cost effectiveness of this drug for the treatment of patients with severe chronic hand eczema (CHE), as part of the Institute's single technology appraisal (STA) process...
- Prevalence and morphology of hand eczema in patients with atopic dermatitisEric L Simpson
Department of Dermatology, Oregon Health and Science University, Portland, OR, USA
Dermatitis 17:123-7. 2006Patients with hand eczema frequently have a history of atopic dermatitis or atopy. No specific morphologic pattern of hand eczema helps distinguish atopic hand eczema from other etiologies...
- Time trends of the prevalence of asthma, rhinitis and eczema in Thai children-ISAAC (International Study of Asthma and Allergies in Childhood) Phase ThreeMuthita Trakultivakorn
Division of Allergy and Clinical Immunology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
J Asthma 44:609-11. 2007..e., current asthma, rhinitis, rhinoconjunctivitis, and flexural eczema. In the older age group, the prevalence of rhinitis and rhinoconjunctivitis increased...
- Trends in prevalence of symptoms of asthma, hay fever, and eczema in 12-14 year olds in the British Isles, 1995-2002: questionnaire surveyH Ross Anderson
Department of Community Health Sciences, St George s Hospital Medical School, London SW17 0RE
BMJ 328:1052-3. 2004
- A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczemaFlorian Schulz
Pediatric Pneumology and Immunology, Charite, Berlin, Germany
J Allergy Clin Immunol 120:1097-102. 2007IL-31 is a novel cytokine that, when overexpressed in transgenic mice, induces severe itching dermatitis resembling human eczema.
- Clinical severity and prognosis of hand eczemaM Hald
National Allergy Research Centre, Gentofte University Hospital, Hellerup, Denmark
Br J Dermatol 160:1229-36. 2009Hand eczema (HE) is a frequent, long-lasting disease with both personal and societal repercussions. Consequently, more information is needed on factors that maintain symptoms.
- The course of eczema in children aged 5-7 years and its relation to atopy: differences between boys and girlsM Mohrenschlager
Department of Dermatology and Allergy Biederstein, Technical University of Munich, Germany
Br J Dermatol 154:505-13. 2006The role of atopy in the pathophysiology of eczema is still under debate. The concept and analyses of the nonatopic and atopic subtypes of eczema have gained increasing interest in recent studies...
- Association between children's household living conditions and eczema in the Polokwane area, South AfricaJanine Wichmann
School of Health Systems and Public Health, Faculty of Health Sciences, University of Pretoria, HW Snyman Building, Gezina, Pretoria, South Africa
Health Place 14:323-35. 2008The aim of the study was to determine the 12-month prevalence of eczema symptoms (ES), the prevalence of ever having had eczema (EE), and potential risk factors among 6-7-year-old children within a 60km radius of Polokwane city centre, ..
- Changing trends in sex specific prevalence rates for childhood asthma, eczema, and hay feverMustafa Osman
Department of Child Health, University of Aberdeen, Aberdeen, Scotland, UK
Pediatr Pulmonol 42:60-5. 2007..34 to 0.98:1 P < 0.0002), for asthma (1.74 to 1.02:1 P < 0.0001), for eczema (1.42:1 to 0.81:1 P < 0.0001) and for hay fever (1.46 to 0.93:1 P < 0.0001)...
- Changes in the prevalence of asthma and allergic diseases among Brazilian schoolchildren (13-14 years old): comparison between ISAAC Phases One and ThreeD Sole
Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of Sao Paulo Escola Paulista de Medicina, Sao Paulo, Brazil
J Trop Pediatr 53:13-21. 2007The present study is aimed to describe the changes in the prevalence of symptoms of asthma, rhinitis and eczema among Brazilian adolescents (AD, 13-14 years old) between Phases 1 and 3 of the International Study of Asthma and Allergies in ..
- Acetaminophen intake and risk of asthma, hay fever and eczema in early adolescenceEmilija Vlaski
Department of Pulmonology and Allergology, University Children s Hospital, Skopje, Republic of Macedonia
Iran J Allergy Asthma Immunol 6:143-9. 2007..The aim of the study was to explore the relationship between acetaminophen intake and asthma, hay fever, and eczema in The Republic of Macedonia as a country with acetaminophen intake not physician-controlled, high passive smoke ..
- Prevalence of childhood asthma, allergic rhinitis and eczema in Urumqi and BeijingT Zhao
Asthma Center, Capital Institute of Paediatrics, Beijing, Hong Kong SAR, PR China
J Paediatr Child Health 36:128-33. 2000..To assess the prevalence of asthma and other allergies in children in Urumqi and Beijing, compared with that in Hong Kong...
- Neonatal head circumference, neonatal weight, and risk of hayfever, asthma and eczema in a large cohort of adolescents from Sheffield, EnglandK A Katz
Department of Dermatology, University of Pennsylvania, Philadelphia, USA
Clin Exp Allergy 33:737-45. 2003..Greater head circumference and lower birth weight have been linked in previous studies to subsequent development of asthma, and greater birth weight has been associated with subsequent development of eczema.
- Effectiveness of skin protection creams in the prevention of occupational dermatitis: results of a randomized, controlled trialRobert Winker
Division of Occupational Medicine, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
Int Arch Occup Environ Health 82:653-62. 2009..The aim of the trial was to investigate whether the publicized effects of skin protection creams can be replicated in a real occupational setting during activities that expose the skin...
- Trends in the epidemiology and prescribing of medication for eczema in EnglandColin R Simpson
Allergy and Respiratory Research Group, Centre for Population Health Sciences, University of Edinburgh, 20 West Richmond Street, Edinburgh EH8 9DX, UK
J R Soc Med 102:108-17. 2009The prevalence of eczema, particularly in younger children, increased substantially over the second half of the 20th century...
- Vitamin D receptor activation improves allergen-triggered eczema in miceBjörn Hartmann
Allergie Centrum Charité, CCM, Klinik für Dermatologie und Allergologie, Charite Universitatsmedizin Berlin, Berlin, Germany
J Invest Dermatol 132:330-6. 2012..of VDR activation by a VDR agonist without calcium-mobilizing activity in a mouse model of allergen-triggered eczema. We show that the systemic administration of the low-calcemic VDR agonist significantly improved the allergen-..
- Psychiatric comorbidity in adult eczemaJ Schmitt
Department of Dermatology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
Br J Dermatol 161:878-83. 2009Atopic eczema (AE) is a common dermatological condition that causes significant problems in everyday life and high levels of illness-related stress in substantial proportions of patients...
- Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort studyA H Ziyab
Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Kuwait
Clin Exp Allergy 40:1776-84. 2010Trends in the prevalence of eczema in the course of childhood and adolescence are not clear although often a net remission during childhood is assumed.
- Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school childrenS J Brown
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Br J Dermatol 161:884-9. 2009Null mutations within the filaggrin gene (FLG) cause ichthyosis vulgaris and are associated with atopic eczema. However, the dermatological features of filaggrin haploinsufficiency have not been clearly defined.
- Targeting Galectin-3 with novel drugs for treatment of eczemaFu Tong Liu; Fiscal Year: 2010b>Eczema affects a wide population age group, and prevalence of the disease has increased two- to three-fold during the past three decades in industrialized countries, where the current incidence in children is estimated to be 15-20%...
- Community Participation Research of Breastfeeding Disparities in African AmericanTamar Ringel Kulka; Fiscal Year: 2009..increased health problems such as ear infections, lower respiratory tract infections, skin rashes similar to eczema, asthmatic episodes, type I and type II diabetes, episodes of infant diarrhea, and incidents of childhood leukemia ..
- Scavenging of Reactive Oxygen and Nitrogen Species by CobalaminsNICOLA ELIZABETH BRASCH; Fiscal Year: 2011..inflammatory disorders including chronic fatigue syndrome, rheumatoid arthritis, asthma, neurological diseases and eczema, with little understanding as to why B12 supplementation is beneficial...
- Proteomic signatures of an early life asthma-protective exposureSerrine S Lau; Fiscal Year: 2010..g., indoor dogs) is associated with strong protection against asthma and asthma-related phenotypes (allergy, eczema) later in life...
- Surveillance of Serum Contents by Mast Cells and Regulation of Allergic ImmunityLaurence E Cheng; Fiscal Year: 2013DESCRIPTION (provided by applicant): The prevalence of allergic diseases, including food allergies, eczema, and asthma, has risen over the last quarter century, and these disorders can lead to significant morbidity for affected patients...
- Protective orthopox immunization in normals and patients with cancer or eczemaEllis Reinherz; Fiscal Year: 2009..Individuals at risk for live-virus vaccine complications, including those with cancer and eczema, comprise a large percentage of the US population, mandating against massive large-scale vaccination...
- Regulation of TSLP receptor expression and function in eczema in mice and manSteven F Ziegler; Fiscal Year: 2013..Such studies could identify new molecular targets for treatment of this debilitating disease. ..
- Perinatal Programming of Infant Stress Reactivity and the Atopic PhenotypeRosalind J Wright; Fiscal Year: 2013..efforts to design programs to prevent the development of atopic disorders, such as asthma, allergic rhinitis and eczema, particularly in high-risk urban populations...
- Host defense against poxviruses and viral immune evasionLiang Deng; Fiscal Year: 2011..weapon, the need for improved vaccination strategies to minimize vaccine-associated complications, such as eczema vaccinatum, and the reimmergence of orthopoxvirus infections in humans such as monkeypox...
- Checkpoints of TNF Gene RegulationAnne Goldfeld; Fiscal Year: 2013..states, including asthma, allergy, arthritis, cardiovascular diseases, inflammatory bowel disease, diabetes, eczema, lupus, several different forms of cancer, and multiple infectious diseases including sepsis, tuberculosis (TB), ..
- The consequences of loricrin deficiency on epidermal barrier functionDENNIS ROOP; Fiscal Year: 2013..of >3000 AD patients controlled for FLG mutations, and he is confident that there is at least one additional eczema gene near FLG...
- Genetic Mapping Of Novel Molecular Players in ItchRACHEL BETH BREM; Fiscal Year: 2013..Mast cells release a variety of puritogens that mediate allergy-evoked itch, psoriasis and eczema, and anti-histamines are not always effective in treating the full spectrum of allergic disorders...
- Role of NOD2 in Inflammatory Arthritis and Innate ImmunityMICHAEL PATRICK DAVEY; Fiscal Year: 2012..and uveal track of the eye), and are associated with Crohn's disease, atopic disorders (allergy, asthma and eczema), and possibly colorectal cancer...
- Transgenerational epigenetic inheritance of allergy in a multigenerational cohortWILFRIED JJ KARMAUS; Fiscal Year: 2013..Asthma, eczema, rhinitis, and allergic sensitization were characterized in F1 at their birth, and at 1, 2, 4, 10 and 18 years...
- S. aureus and Regulatory T cells in the Failure of Oral ToleranceAnne Marie Singh; Fiscal Year: 2013..Her previous research studying the phenotypic expression of early eczema and role of regulatory T cells in allergy makes her uniquely qualified to study early mechanisms of loss of ..
- The Epidemiology of Home Allergens and AsthmaDiane R Gold; Fiscal Year: 2010..We found reduced pro-inflammatory Th2 cytokine production at age 2, reduced risk of eczema, and subsequent reduced allergy/allergic rhinitis risk by age 7 in children with elevated levels in infancy of ..
- Genetic and Environmental Determinants of Food AllergyCorinne Keet; Fiscal Year: 2013..Although it has long been observed that eczema tends to lead to FA, why this is the case is unknown. Previous work by Dr...
- Aging Stratum Corneum pH and Barrier FunctionTheodora M Mauro; Fiscal Year: 2012DESCRIPTION (provided by applicant): Aged skin commonly is afflicted by inflammatory skin diseases or xerosis/eczema that can be traced to, or exacerbated by, impaired epidermal permeability barrier homeostasis...
- Dermatotropic cellular immune responses induced by a novel smallpox vaccineStephen R Walsh; Fiscal Year: 2013..the kinetics, magnitude, and trafficking marker expression of orthopoxvirus-specific T cells in subjects with eczema or atopic dermatitis vaccinated with MVA...
- RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMARobert Strunk; Fiscal Year: 2013..with reduced secondary outcomes in the child of (a) allergic sensitization, (b) doctor's diagnosis of eczema and (c) lower respiratory tract infections during the first 3 years of life;and (2) To determine whether adequate ..
- RANDOMIZED TRIAL: MATERNAL VITAMIN D SUPPLEMENTATION TO PREVENT CHILDHOOD ASTHMAScott T Weiss; Fiscal Year: 2013..with reduced secondary outcomes in the child of (a) allergic sensitization, (b) doctor's diagnosis of eczema and (c) lower respiratory tract infections during the first 3 years of life;and (2) To determine whether adequate ..
- Intestinal Barrier Function: Protective Effects of CurcuminPawel R Kiela; Fiscal Year: 2013..These include atopic disease such eczema, food allergies, celiac enteropathy, type 1 diabetes, asthma, and inflammatory bowel disease...
- Genetic Heterogeniety of the Hyper IgE SyndromeTALAL AMINE CHATILA; Fiscal Year: 2010The Hyper-IgE Syndrome (HIES) is a primary immunodeficiency disorder characterized by eczema, elevated serum IgE, skeletal and connective tissue abnormalities, and diminished inflammatory responses...
- Role of DOCK8 in B Cell FunctionRAIF SALIM GEHA; Fiscal Year: 2013..factor, results in autosomal recessive Hyper-IgE syndrome characterized by recurrent pulmonary infections, eczema, cutaneous viral infections, elevated serum IgE levels, food allergy, low numbers of T cells, and deficient ..
- Early Life DNA Methylation and Childhood Allergic DiseaseAugusto A Litonjua; Fiscal Year: 2013DESCRIPTION (provided by investigator): Allergic disorders, such as asthma and eczema, are the most common chronic diseases of childhood in developed countries...
- A Novel Class of Therapeutic Agents for the Treatment of Skin Diseases AssociatedJoel S Gordon; Fiscal Year: 2010..novel pharmaceutical leads for the treatment of inflammatory skin diseases associated with erythema such as eczema (e.g. atopic dermatitis, seborrheic dermatitis) and rosacea...
- Breastfeeding RCT: Adolescent Neurocognitive and Respiratory FunctionEmily Oken; Fiscal Year: 2013DESCRIPTION (provided by applicant): Breastfeeding improves health outcomes in infancy, including risks for eczema and gastrointestinal infections, but the long-term physiological effects of breastfeeding on child health are less clear...
- VDAART FLORA ANCILLARY STUDYDiane R Gold; Fiscal Year: 2013..reduce the risk of wheeze, recurrent wheeze (>2 reports of wheeze in the previous year), atopic dermatitis (eczema), and sensitization to >1 allergen at 1 year of age...
- Type 2 Immunity: Initiation, Maintenance, Homeostasis and PathologyJAMES WAVELL AIKEN; Fiscal Year: 2013..In developed countries, asthma, eczema and food allergies have increased over the past few decades to become the most prevalent chronic illnesses of ..
- Does a Psychiatric Comorbidity Affect the Management of DiabetesJohn B McKinlay; Fiscal Year: 2012..varying levels of stigma (schizophrenia with bizarre affect;schizophrenia with normal affect;depression, and eczema) influence clinical management of the videotaped vignette scenario...
- Innate vs Adaptive Contributions to Th2 Pathology in Wiskott Aldrich SyndromeDeborah J Fowell; Fiscal Year: 2012..In contrast, WAS patients exhibit increased IgE levels and atopic dermatitis/eczema. Our data in the mouse suggest that the elevated Type 2 response in the absence of WASp may be driven by innate ..
- Sphingosine-1-Phosphate, A Novel Mediator of Human Skin Mass Cell FunctionsCarole A Oskeritzian; Fiscal Year: 2010..to environmental stimuli is a fundamental feature of atopy that manifests itself through atopic dermatitis or eczema. Mast cells are distributed widely in the skin and increased in number in atopic dermatitis (AD)...
- Elucidating the Fas-activated inflammation-signaling complex (FISC)Mihail Iordanov; Fiscal Year: 2013..mechanisms of Fas-induced inflammation will improve our understanding of the involvement of Fas in pathology (from eczema to neuroinflammation) and treatment (such as immunotherapy of cancer)...
- The F-BAR protein CIP4 in WAS-dependent thrombocytopeniaSETH JOEL COREY; Fiscal Year: 2012..The Wiskott -Aldrich syndrome (WAS) is an X- linked disorder characterized by thrombocytopenia, immunodeficiency, eczema and an increased risk of lymphoma and autoimmunity. The affected gene encodes the cytoskeletal protein, WASP...
- Filaggrin Mutations and the Prognosis of Atopic DermatitisDavid J Margolis; Fiscal Year: 2013..The Pediatric Eczema Elective Registry (PEER) is an ongoing prospective 10-year observational registry that is part of a post-marketing ..
- Engineering Hetero-Bivalent Ligands to Inhibit IgE Clustering on Mast CellsZIHNI BASAR BILGICER; Fiscal Year: 2013..up to 12 million Americans have food allergies, 10 million suffer from allergic asthma, 10 million suffer atopic eczema, 36 million have allergic rhinitis, and the prevalence is rising...
- Functional Metagenomic Reprogramming of the Human Microbiome through Mobilome EngHarris H Wang; Fiscal Year: 2013..g. Crohn's, IBD, chronic maldigestion), oral cavity (e.g. dental caries), urogenital tract (e.g. infections, STDs), and skin (e.g. ectopic eczema).
- The Microbiome Drives Mast Cell Recruitment in the SkinAnna Di Nardo; Fiscal Year: 2013..More specifically, this work has implications for fighting infections, psoriasis, and atopic dermatitis (eczema), with longer term significance fr asthma and hay fever.
- Efficacy of IgE in Mediating Allergic Reactions in VivoDonald W Macglashan; Fiscal Year: 2010The central element in allergic diseases such as asthma, rhinitis and eczema, is the presence of IgE antibody...
- Murine Model of Job's syndromeJohn P Manis; Fiscal Year: 2012..The Hyper-IgE syndrome (HIES) is a primary immunodeficiency disorder generally characterized by chronic eczema, recurrent staphylococcal infections, and increased serum IgE levels...
- Novel Topical Treatment of EczemaBakul Bhatt; Fiscal Year: 2006..provided by applicant): Irritant and allergic contact dermatitis affect approximately 10% of adults, and hand eczema represents 1 of the 4 most common occupationally related diseases, accounting for substantial lost earning ..
- NUTRITIONAL SIGNIFICANCE OF POLYUNSATURATED FATTY ACIDSVincent Ziboh; Fiscal Year: 1990..coronary heart disease while Evening Primrose oil (which contains LA (18:2n6) and GLA (18:3n6)) can improve atopic eczema. A serious flaw in these studies is the lack of information on the biological effects of the constituent PUFAs ..
- A Twin Study of Chronic Fatigue Syndrome in SwedenNancy Pedersen; Fiscal Year: 2003..fatigue, several overlapping conditions (fibromyalgia, irritable bowel syndrome, tension headache, allergy/eczema, generalized anxiety disorder, and major depression), and a detailed medical history...
- Pre-clinical Studies on Lupinus termis Seeds ExtractMIKHAIL ANTOUN; Fiscal Year: 2003..studies performed outside the US, demonstrated encouraging activity in the management of chronic hand and foot eczema. The results that will be obtained will be used to develop a future R01 grant application that will include a ..
- Risk Factors for Eczema Vaccinatum in Atopic DermatitisWalter Holleran; Fiscal Year: 2009..Because eczema vaccinatum is a feared complication of the Vaccinia vaccine, stringent criteria have excluded persons who ..
- Development of a Safer Smallpox VaccineMichael Cho; Fiscal Year: 2003..Although existing smallpox vaccine is relatively safe, it is not without serious medical complications including eczema vaccinatum, vaccinia necrosum, and encephalitis...
- MECHANISMS OF PHOSPHOLIPASE A2 REGULATIONJohn Bell; Fiscal Year: 1990..including rheumatoid arthritis inflammatory hyperemia, inflammatory problems associated with burns and trauma, eczema, psoriasis, pancreatitis, trypanosomiasis, amoebiasis, myocardial infarction, ischemia, alveolar proteinasis, ..
- Allergic Condition Biomarkers and Glioma RiskJudith Schwartzbaum; Fiscal Year: 2004..Study participants were asked whether they have been diagnosed with asthma, eczema, hay fever or other allergies, continue to have allergies, have symptoms of allergies without a diagnosis, and ..
- Anxiety & Inflammatory Correlates in Youth w/EczemaMarcia Slattery; Fiscal Year: 2005..youth with atopic dermatitis (AD), a chronic and often psychosocially devastating skin disorder commonly known as eczema. The investigation posits an association between anxiety and allergic inflammation, the pathophysiological ..
- ATOPIC DERMATITIS RESEARCH NETWORKDAVID LEUNG; Fiscal Year: 2010..as the underlying mechanisms for susceptibility of individuals with AD to cutaneous infectious diseases, including eczema vaccinatum (EV), eczema herpeticum (EH), and Staphylococcus aureus (SA) infections...
- IMMUNOMODULATION OF VACCINIA-INDUCED ANTIMICROBIAL PEPT*Donald Leung; Fiscal Year: 2005..In particular, patients with atopic dermatitis (AD) are at high risk of developing eczema vaccinatum (EV), a serious potentially fatal side effect of smallpox vaccination that is associated with skin ..
- Intradermal vaccinia:T-cell specificity and skin homingDavid Koelle; Fiscal Year: 2005..T-cell homing could be relevant to the pathogenesis of Dryvax-associated eczema vaccinatum, which is seen in persons with atopic dermatitis, a condition marked by excess CLA expression...
- Scanning the Vaccinia Proteome for antiSmallpox AntigensDavid Roth; Fiscal Year: 2002..This vaccine will have no risk of producing vaccinia virus disease or Eczema vaccinatum.
- Defects of Thymic Output in Wiskott-Aldrich SyndromeEILEEN REMOLD O DONNELL; Fiscal Year: 2006..syndrome (WAS) is a rare inherited platelet/ immunodeficiency disease characterized by thrombocytopenia, eczema, infections and frequency of autoimmune disorders and malignancies...
- Genetics of Allergic Disease in a Participatory Research CohortDAVID ALAN HINDS; Fiscal Year: 2012..report one or more allergies, more than 8000 report an asthma diagnosis, and more than 5000 report having eczema. Our objective is to use the 23andMe cohort to investigate the genetic and environmental basis of asthma and ..
- International Symposium on Atopic DermatitisJon Hanifin; Fiscal Year: 2001..on the prevalence, incidence, and costs of occupational dermatoses, specifically allergic contact dermatitis/hand eczema; 6) Improve the public awareness regarding the scope and prevalence of AD and the range of therapeutic options ..
- CELLULAR DEFECTS IN THE WISKOTT/ALDRICH SYNDROMEEILEEN REMOLD O DONNELL; Fiscal Year: 2001..The most common manifestations of this disease are thrombocytopenia and T lymphocyte based immune defects (eczema etc.)...
- Atopic Dermatitis and Vaccinia Immunization Network Clinical ConsortiumDONALD YM LEUNG; Fiscal Year: 2009..Network (ADVN) is to develop and implement a comprehensive long-term scientific plan to eliminate the risk for eczema vaccinatum or other adverse reactions to vaccinia immunization in patients with atopic dermatitis...
- Genetic & epidemiologic cohort study of asthma & allergySusan Ewart; Fiscal Year: 2009DESCRIPTION (provided by applicant): Dramatic increases in the incidence and severity of allergic asthma, eczema, hay fever and food allergy have been seen recently, particularly in children;every fourth child in the U.S. is affected...
- MOLECULAR AND GENETIC ANALYSIS OF A BLOOD CELL DISEASEScott Snapper; Fiscal Year: 2001..Syndrome (WAS), a severe X-linked disease that is characterized by a B-and T-cell immunodeficiency, eczema, bloody diarrhea, and thrombocytopenia. Two strategies will be used to develop a mouse model of the WAS...
- Pet Exposure, Allergy and Early Asthma in the Inner-CityMatthew Perzanowski; Fiscal Year: 2005..3) Determine whether pet allergen exposure in an inner-city community is associated with early predictors of allergic disease and asthma including persistent wheeze, doctor diagnosed eczema and asthma symptoms.
- EICOSAPENTAENOIC ACID FOR TOPICAL SKIN DISEASE TREATMENTRODNER WINGET; Fiscal Year: 1993..containing eicosapentaenoic acid (EPA) isolated from cultured marine algae, for topical treatment of psoriasis, eczema, and acne. Commercial application is to supply a pharmaceutical firm with bulk product...
- Roles of the WASP N-terminus in hematopoietic cellsShigeru Tsuboi; Fiscal Year: 2006..Wiskott-Aldrich syndrome (WAS) is an X chromosome-linked recessive disorder characterized by a crinical triad of eczema, thrombocytopenia and immunodeficiency...
- SCOR IN CELLULAR AND MOLECULAR MECHANISMS OF ASTHMAFernando Martinez; Fiscal Year: 2005..2, the genetic and immune factors that explain the strong and independent relation between atopic dermatitis (eczema) in early life and the subsequent development of asthma will be explored...