Genomes and Genes
Summary: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.
Publications238 found, 100 shown here
- Differential diagnosis of severe cutaneous drug eruptionsNicolas Bachot
Department of Dermatology, Hopital Henri Mondor, Universite Paris XII, Creteil, France
Am J Clin Dermatol 4:561-72. 2003..They are the more severe drug eruptions, with a mortality around 30% for TEN...
- Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemiaYoko Kano
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Arch Dermatol 140:183-8. 2004..The identification of predisposing factors is clearly needed to predict the incidence and outcome of AHS; attention has recently been focused on reactivation of human herpesvirus 6 (HHV-6)...
- Idiosyncratic adverse reactions to antiepileptic drugsGaetano Zaccara
Neurology Unit, ASL 10, Firenze, Italy
Epilepsia 48:1223-44. 2007..Serious consequences of idiosyncratic reactions can be minimized by knowledge of risk factors, avoidance of specific AEDs in subpopulations at risk, cautious dose titration, and careful monitoring of clinical response...
- Skin toxicity evaluation protocol with panitumumab (STEPP), a phase II, open-label, randomized trial evaluating the impact of a pre-Emptive Skin treatment regimen on skin toxicities and quality of life in patients with metastatic colorectal cancerMario E Lacouture
Northwestern University, Chicago, IL, USA
J Clin Oncol 28:1351-7. 2010..This is the first study designed to examine differences between pre-emptive and reactive skin treatment for specific skin toxicities in patients with mCRC for any EGFR inhibitor...
- Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han ChineseCeleste B L Man
Division of Neurology, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China
Epilepsia 48:1015-8. 2007..Identification of genetic polymorphisms predisposing to development of AED-induced SCR offers the possibility of avoiding these high-risk drugs in genetically susceptible individuals...
- Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in KoreansSae Hoon Kim
Department of Internal Medicine, Seoul National University College of Medicine, Republic of Korea
Epilepsy Res 97:190-7. 2011..This study investigated the association between the HLA class I genotype and carbamazepine-induced severe cutaneous adverse reaction (SCAR) in Koreans...
- HLA class I markers in Japanese patients with carbamazepine-induced cutaneous adverse reactionsHiroko Ikeda
National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
Epilepsia 51:297-300. 2010..These data may suggest that HLA-B*5901 is one of the candidate markers for CBZ-induced SJS in Japanese...
- Drug eruptions in the elderlySueli Coelho da Silva Carneiro
Sector of Dermatology and Post Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rua Farme de Amoedo 140 601, 22420 020 Rio de Janeiro, Brazil
Clin Dermatol 29:43-8. 2011..The potential benefits of appropriately prescribed medications are unquestionable, but the possibility of an adverse reaction must be recognized and prevented in older people so they can have a better quality of life...
- Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han populationFa Yun Hu
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
Seizure 20:160-2. 2011..In the present study, we conducted a pilot study to detect a possible association of oxcarbazepine (OXC)-induced MPE with HLA-B*1502 allele in Chinese Han population...
- Generalized exacerbation of psoriasis associated with imiquimod cream treatment of superficial basal cell carcinomasN Rajan
Clin Exp Dermatol 31:140-1. 2006
- Genetic polymorphism of cytochrome P450 2C9 in diphenylhydantoin-induced cutaneous adverse drug reactionsAi Young Lee
Department of Dermatology, Eulji Hospital, Eulji University School of Medicine, 280 1 Hagye 1 dong, Nowon Gu, 139 711 Seoul, South Korea
Eur J Clin Pharmacol 60:155-9. 2004..Genetic polymorphisms leading to altered metabolic processes of cytochrome P(450) (CYP) 2C9, a main metabolic enzyme for DPH, may be the pathological mechanism for certain cases of DPH-induced CADRs...
- Severe adverse cutaneous drug eruptions: epidemiological and clinical featuresInes Zaraa
Dermatology Department, La Rabta Hospital, Jabbari, Bab Saadoun 1007, Tunis, Tunisia
Int J Dermatol 50:877-80. 2011..Adverse cutaneous drug reactions (ACDR) are common, and some can be lethal. The aim of our study was to discuss the epidemiological and clinical features of severe ACDR...
- Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patientsSue Mian Then
UKM Medical Molecular Biology Institute UMBI, Universiti Kebangsaan Malaysia UKM, Kuala Lumpur, Malaysia
Asian Pac J Allergy Immunol 29:290-3. 2011..In conclusion, this study confirmed the association of HLA-B*1502 with CBZ-SJS among Malaysian epilepsy patients, however there might be other genes that could be responsible for the CBZ-induced rash...
- Cutaneous reaction to drugs used for erectile dysfunction: case report and review of the literatureRenee A Beach
Department of Medicine, McMaster University, Hamilton, ON
J Cutan Med Surg 10:128-30. 2006..These drugs, phosphodiesterase 5 (PDE5) inhibitors, help men with ED obtain and sustain an erection, improving both sexual function and sexual performance satisfaction. However, these drugs contain side effects...
- Cutaneous side effects of anti-tumor necrosis factor biologic therapy: a clinical reviewAikaterini Evaggelia Moustou
1st Department of Dermatology, Andreas Sygros Hospital, University of Athens Medical School, Athens, Greece
J Am Acad Dermatol 61:486-504. 2009..Anti-tumor necrosis factor (anti-TNF) biologic agents have been associated with a number of adverse events...
- Progress in the understanding of the pathology and pathogenesis of cutaneous drug eruptions : implications for managementA Neil Crowson
University of Oklahoma and Regional Medical Laboratories, Tulsa, Oklahoma, USA
Am J Clin Dermatol 4:407-28. 2003Cutaneous drug eruptions are among the most common adverse reactions to drug therapy. The etiology may reflect immunologic or nonimmunologic mechanisms, the former encompassing all of the classic Gell and Combs immune mechanisms...
- Exanthematous drug eruption due to valsartanGunseli Ozturk
Department of Dermatology and Venerology, Ege University Medical Faculty, Izmir, Turkey
Cutan Ocul Toxicol 31:335-7. 2012..The well-known adverse effects of valsartan are dizziness, headache and cough. Valsartan-related cutaneous side effects have been reported previously in a limited number of case reports...
- Differences in immunological alterations and underlying viral infections in two well-defined severe drug eruptionsK Hirahara
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Clin Exp Dermatol 35:863-8. 2010....
- Fixed drug eruptions due to cotrimoxazoleM A Miah
Department of Dermatology and Venereology, Mymensingh Medical College and Hospital, Mymensingh, Bangladesh
Mymensingh Med J 17:S1-5. 2008..44% cases. Sites of involvement in cases of FDE due to cotrimoxazole (n=36) were as follows: lips 58.33%, genitalia 33.33%, oral 13.89%, trunk 38.89%, limbs 55.56%, hands 16.67%, feet 19.44%, face 19.44% and conjunctiva 2.78%...
- Cutaneous reactions induced by oxcarbazepine in Southern Han Chinese: incidence, features, risk factors and relation to HLA-B allelesNa He
Institute of Neuroscience and The Second Affiliated Hospital of GuangZhou Medical University, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Guangzhou 510260, China
Seizure 21:614-8. 2012..Additionally, these reactions are thought to be associated with HLA-B*1502. This study aims to investigate the incidence, features and risk factors of OXC-cADRs, and to explore their relation to HLA-B alleles in Southern Han Chinese...
- Subacute cutaneous lupus erythematosus induced by terbinafine: case report and review of literatureKatharina Lorentz
Department of Dermatology, University Clinic of Mannheim, Medical School of Mannheim at the University of Heidelberg, Germany
J Dtsch Dermatol Ges 6:823-7, 823-8. 2008..In all cases terbinafine-induced SCLE resolved after discontinuation of the triggering agent. Systemic treatment with anti-malarials and/or corticosteroids does not appear to be mandatory...
- [Drug-induced lupus erythematosus tumidus during treatment with adalimumab]S Sohl
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Leipzig AoR, Philipp Rosenthal Strasse 23 25, 04103 Leipzig
Hautarzt 60:826-9. 2009..We report on a patient with rheumatoid arthritis, who developed anti-histone antibodies and lupus tumidus after eight months on adalimumab therapy...
- Patch testing in fixed drug eruptions--a 20-year reviewPedro Andrade
Department of Dermatology and Venereology, Coimbra University Hospital, 3000 075 Coimbra, Portugal
Contact Dermatitis 65:195-201. 2011..The fixed drug eruption is a common adverse drug reaction. Clear identification of the culprit drug is not always possible in the clinical setting, and oral rechallenge may induce new lesions or severe reactions...
- Clinical and laboratory assays in the diagnosis of cutaneous adverse drug reactionsIlan Goldberg
Isr Med Assoc J 6:50-1. 2004
- Pathogenesis of drug-induced exanthemsW Pichler
Division of Allergology, Clinic for Rheumatology and Clinical Immunology Allergology, Inselspital, University of Bern, Switzerland
Allergy 57:884-93. 2002
- Carbamazepine-induced acute granulomatous interstitial nephritisJ Hegarty
Department of Renal Medicine, Hope Hospital, Salford, UK
Clin Nephrol 57:310-3. 2002..Percutaneous renal biopsy revealed acute granulomatous interstitial nephritis, which responded successfully to high-dose oral steroid therapy...
- Management of drug rash with eosinophilia and systemic symptoms (DRESS syndrome): an updateS Tas
Department of Dermatology, Erasme University Hospital, Brussels, Belgium
Dermatology 206:353-6. 2003..In the absence of a well-established therapy, primary and secondary prevention have a key role in the management of DRESS syndrome...
- Cutaneous adverse drug reactions: clinical pattern and causative agents--a 6 year series from Chandigarh, IndiaV K Sharma
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India
J Postgrad Med 47:95-9. 2001..To study the different clinical spectrum of cutaneous adverse drug reactions (ADR) and to determine the causative drugs...
- The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drugYoko Kano
Department of Dermatology, Kyorin University School of Medicine, 6 20 2 Shinkawa Mitaka, Tokyo 181 8611, Japan
Immunol Allergy Clin North Am 29:481-501. 2009..A better understanding of the interplay in the development of DIHS/DRESS has implications for safer and more efficient treatment of this syndrome...
- Cytokine and chemokine expression in the skin from patients with maculopapular exanthema to drugsT D Fernandez
Research Laboratory for Allergic Diseases, Carlos Haya Hospital Fundacion IMABIS, Malaga, Spain
Allergy 63:712-9. 2008..We assessed the role of cytokines and chemokines and their receptors in the pathogenesis of MPE...
- Life-threatening acute adverse cutaneous drug reactionsRonni Wolf
Dermatology Unit, Kaplan Medical Center, 76100 Rechovot, Israel
Clin Dermatol 23:171-81. 2005..Therefore, dermatologists should be familiar with these conditions and be prepared to handle them adequately...
- Clinical pattern of cutaneous drug eruption among children and adolescents in north IndiaV K Sharma
Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Pediatr Dermatol 12:178-83. 1995Various types of cutaneous drug eruptions and the incriminating drugs were analyzed in 50 children and adolescents up to 18 years of age (34 or 65% boys, 16 or 32% girls)...
- Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimodP A Fanti
Int J Dermatol 45:1464-5. 2006
- Dermatologic toxicities associated with EGFR inhibitors: the clinical psychologist's perspective. Impact on health-related quality of life and implications for clinical management of psychological sequelaeLynne I Wagner
Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Northwestern University, Feinberg Medical School, Chicago, IL 60611, USA
Oncology (Williston Park) 21:34-6. 2007..Cognitive behavioral strategies may also be useful in helping patients manage anxiety and depression associated with any changes in their social function caused by skin rash, as well as distress associated with having a cancer diagnosis...
- Clinical implications of in vitro drug-induced interferon gamma release from peripheral blood lymphocytes in cutaneous adverse drug reactionsSima Halevy
Department of Dermatology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
J Am Acad Dermatol 52:254-61. 2005..Drug-specific T cells are involved in the pathogenesis of cutaneous adverse drug reactions (CADRs)...
- Drug-induced lupus: an updateS Vasoo
Division of Rheumatology, Department of Medicine, National University Hospital, Singapore
Lupus 15:757-61. 2006..This review discusses the clinical presentation, diagnosis of DILE as well as provides an update on postulated pathogenic mechanisms and an overview of implicated drugs...
- Drug-induced lupus erythematosusDimitar Antonov
Department of Dermatology and Venereology, Sofia Faculty of Medicine, Sofia, Bulgaria
Clin Dermatol 22:157-66. 2004..This review discusses the general issues in DILE, such as pathogenic mechanisms, clinical forms, and diagnostic criteria, and provides more detailed information for some of the implicated drugs: minocycline, statins, terbinafine, etc...
- Cutaneous adverse drug reactions: a 9-year study from a South Indian HospitalM Sushma
Department of Pharmacology, St John s Medical College, Bangalore, India
Pharmacoepidemiol Drug Saf 14:567-70. 2005....
- Fixed drug eruption: a disease mediated by self-inflicted responses of intraepidermal T cellsTetsuo Shiohara
Kyorin University School of Medicine, 6 20 2, Shinkawa, Mitaka, Tokyo, Japan
Eur J Dermatol 17:201-8. 2007..In this review, we ask how they arise and how they cause epidermal injuries, which present with a wide spectrum of clinical manifestations and are often mistaken as signs of other skin disease...
- Cross-sensitivity of skin rashes with antiepileptic drug useL J Hirsch
Associate Clinical Comprehensive Epilepsy Center, Columbia University, Neurological Institute, New York, NY 10032, USA
Neurology 71:1527-34. 2008..To determine rates of cross-sensitivity of rash among commonly used antiepileptic drugs (AEDs) in patients with epilepsy...
- Induction of hypersensitivity to a previously tolerated antiepileptic drug by a second antiepileptic drugB D Klassen
Division of Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
Epilepsia 42:433-5. 2001..This is distinct from simple cross-reactivity between one or more drugs. Such induction of hypersensitivity with AEDs has not been previously described...
- Early skin toxicity as a predictive factor for tumor control in hepatocellular carcinoma patients treated with sorafenibBruno Vincenzi
Department of Surgical and Oncological Sciences, Section of Medical Oncology Università di Palermo, Palermo, Italy, Via del Vespro 127, 90127 Palermo, Italy
Oncologist 15:85-92. 2010..This study was conducted to assess the link between the antitumor efficacy of sorafenib and its early cutaneous side effects in advanced HCC patients...
- Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcomeRyo Takahashi
Division of Flow Cytometry, Kyorin University Graduate School of Medicine, Mitaka, Tokyo, Japan
J Immunol 182:8071-9. 2009..necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) represent two ends of a spectrum of severe drug eruptions: DIHS is unique in that severe epidermal damage seen in TEN is absent, sequential reactivations of ..
- Recognition of immune reconstitution syndrome necessary for better management of patients with severe drug eruptions and those under immunosuppressive therapyTetsuo Shiohara
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Allergol Int 59:333-43. 2010..with a broad-spectrum of immunosuppressive therapy-related opportunistic infectious diseases and severe drug eruptions complicated by viral reactivations...
- Comparison and predictors of rash associated with 15 antiepileptic drugsH Arif
Comprehensive Epilepsy Center, Department of Neurology, Columbia University, New York, NY 10032, USA
Neurology 68:1701-9. 2007..To determine predictors and relative incidence of antiepileptic drug (AED)-related rash in patients taking all common AEDs...
- Fixed drug eruptions. Incidence, recognition, and avoidanceA Y Lee
Department of Dermatology, Eulji Hospital College of Medicine, Seoul, South Korea
Am J Clin Dermatol 1:277-85. 2000b>Drug eruptions often have nonspecific clinical findings, and the evaluation of the probability of an eruption being a drug-induced event is difficult...
- Cutaneous drug eruptions: a 5-year experienceDeborah Gerson
The Arkadi M Rywlin, M D Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center of Greater Miami, Miami, Florida, USA
J Am Acad Dermatol 59:995-9. 2008The diversity of cutaneous drug eruptions encompasses many clinicopathologic entities.
- Clinical study of cutaneous drug eruptions in 200 patientsM Patel Raksha
Department of Skin and V D, Medical College, Vadodara, India
Indian J Dermatol Venereol Leprol 74:80. 2008..The youngest was 1 year old and the oldest was 80 years old. Period of development of lesion after intake of drug varied from 1 day to 45 days. Cotrimoxazole was the commonest drug, in 26 cases; followed by Ibuprofen in 20 cases...
- Adverse cutaneous drug eruptions and HIV: a clinician's global perspectiveGail Todd
Division of Dermatology, University of Cape Town, Faculty of Health Sciences, Nard 623, Cape Town, South Africa
Dermatol Clin 24:459-72, vi. 2006..When no effective alternate therapy is available, drug rechallenge in HIV-infected patients can be attempted with little morbidity or mortality if done according to rationalized protocols...
- Fixed drug eruption caused by itraconazole: Reactivity and cross reactivityRajan Gupta
J Am Acad Dermatol 58:521-2. 2008
- T cell involvement in cutaneous drug eruptionsY Hari
Allergy Division of the Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern, Switzerland
Clin Exp Allergy 31:1398-408. 2001..A predominant CD8(+) T cell activation leads to more severe (bullous) skin symptoms or liver involvement, while predominant activation of CD4(+) cells elicits mainly maculo-papular reactions...
- Chemotherapeutic agents and the skin: An updateNoushin Heidary
Ronald O Perelman Department of Dermatology, New York University, New York, USA
J Am Acad Dermatol 58:545-70. 2008..Particular emphasis is placed on the novel signal transduction inhibitors as well as on newer literature pertaining to previously described reactions...
- Adverse cutaneous reactions to anakinra in patients with rheumatoid arthritis: clinicopathological study of five patientsA T Vila
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Br J Dermatol 153:417-23. 2005..Anakinra, a recombinant human form of interleukin-1 receptor antagonist, is used to treat patients with active rheumatoid arthritis (RA)...
- Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responsesTetsuo Shiohara
Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
Allergol Int 55:1-8. 2006..This review includes discussion of the pathomechanism, the clinical symptoms, laboratory findings, pathological findings and therapy...
- Common side effects of anti-EGFR therapy: acneform rashRebecca Sipples
Yale Comprehensive Cancer Center, 333 Cedar Street, New Haven, CT 06520, USA
Semin Oncol Nurs 22:28-34. 2006..To review the general toxicity profile of EGFR-targeted therapies and the management of the most common side effect, skin toxicity...
- Carbamazepine-induced DRESS syndrome with recurrent fever and exanthemaJulia Valencak
Department of Dermatology, Division of General Dermatology, University of Vienna, Vienna, Austria
Int J Dermatol 43:51-4. 2004
- Two cases of acneiform eruption induced by inhibitor of epidermal growth factor receptorG Gencoglan
Department of Dermatology, Medical Faculty of Afyon Kocatepe University, Afyon, Turkey
Skin Pharmacol Physiol 20:260-2. 2007..Cetuximab is a member of a new family of antineoplastic agents that inhibit the epidermal growth factor receptor (EGF-R), and which are increasingly being used in the treatment of solid tumors...
- Drug hypersensitivity to previously tolerated phenytoin by carbamazepine-induced DRESS syndromeCheol Woo Kim
Department of Internal Medicine, Inha University College of Medicine, Jung Gu, Incheon, Korea
J Korean Med Sci 21:768-72. 2006....
- Cytomegalovirus disease during severe drug eruptions: report of 2 cases and retrospective study of 18 patients with drug-induced hypersensitivity syndromeYusuke Asano
Department of Dermatology, Kyorin University School of Medicine, 6 20 2 Shinkawa Mitaka, Tokyo 181 8611, Japan
Arch Dermatol 145:1030-6. 2009..Cutaneous lesions, albeit rare, occur as late systemic manifestations of CMV infections and are usually fatal...
- Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactionsA Barbaud
Dermatology Department, Hopital Fournier, 54000 Nancy, France
Contact Dermatitis 45:321-8. 2001..The results of drug skin tests also depend on the clinical features of the CADR. The use of appropriate control patients is necessary to avoid false-positive results...
- Clinical research of EGFR inhibitors and related dermatologic toxicitiesRoman Perez-Soler
Division of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA
Oncology (Williston Park) 21:10-6. 2007..Rational treatments based on the biological mechanisms of the skin toxicity must be developed and tested in well-controlled clinical trials...
- Insulin-induced drug eruptions and reliability of skin testsAl Young Lee
Department of Dermatology, Eulji Hospital, Eulji University School of Medicine, Seoul, South Korea
Acta Derm Venereol 82:114-7. 2002..Allergic reactions to protamine sulfate are common and should not be ignored. This study shows a good correlation between clinical manifestations and skin test reactions for insulin allergy...
- [Retrospective analysis of adverse cutaneous drug reactions in patients hospitalized in Department of Dermatology and Venereology of Pomeranian Medical University in 1996-2006]Anna Kacalak-Rzepka
Katedra i Klinika Chorób Skórnych i Wenerycznych Pomorskiej Akademii Medycznej w Szczecinie al Powstańców Wlkp 72, 70 111 Szczecin
Ann Acad Med Stetin 54:52-8. 2008....
- Tissue eosinophilia: not an indicator of drug-induced subacute cutaneous lupus erythematosusPaul B Hillesheim
Department of Pathology and Laboratory Medicine, University of Louisville, 530 S Jackson St, Louisville, KY 40202, USA
Arch Dermatol 148:190-3. 2012..To investigate whether tissue eosinophilia is a differentiating histopathologic feature of drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) compared with non-DI-SCLE...
- Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitorsA F S Galimont-Collen
Department of Dermatology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Eur J Cancer 43:845-51. 2007..Informing the patient and management of these side-effects is very important to reduce discomfort and as such to increase compliance to therapy...
- Fixed drug eruptions: a case report and review of the literatureSarah B Gendernalik
Naval Air Station Whidbey Island, Oak Harbor, Washington, USA
Cutis 84:215-9. 2009Fixed drug eruptions (FDEs) have been described since 1889 with continually evolving documentation of implicated agents and clinical presentations. We report a case of FDE as a reaction to naproxen sodium in a 27-year-old woman...
- A three-year-analysis of fixed drug eruptions in hospital settings in FranceNesrine Brahimi
Department of Dermatology, Bichat Hospital, APHP, 46 rue Henri Huchard, 75877 Paris, France
Eur J Dermatol 20:461-4. 2010..The sex-dependent distribution could help our understanding of the pathophysiology of fixed drug eruption...
- In vitro drug allergy detection system incorporating human liver microsomes in chlorazepate-induced skin rash: drug-specific proliferation associated with interleukin-5 secretionB Sachs
Department of Dermatology and Allergology, University Hospitals, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
Br J Dermatol 144:316-20. 2001..We report a woman who developed a generalized exanthem 1 day after receiving chlorazepate and four other drugs related to anaesthesia for surgery of the larynx. Patch tests pointed to chlorazepate as the culprit drug for the skin rash...
- ACE-inhibitor-induced drug eruption resembling lymphocytic infiltration (of Jessner-Kanof) and Lupus erythematosus tumidusCarmelo Schepis
Dermatology 208:354-5. 2004
- Toward evidence-based management of the dermatologic effects of EGFR inhibitorsPatricia LoRusso
Phase I Clinical Trial Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA
Oncology (Williston Park) 23:186-94. 2009..These reports represent the first step toward an evidence-based approach to the prevention and management of these important effects...
- Drug eruptions and other adverse drug effects in aged skinJohn R Sullivan
Drug Safety Clinic, Department of Medicine, University of Toronto Medical School, Ontario, Canada
Clin Geriatr Med 18:21-42. 2002....
- Clinical study of cutaneous drug eruptions in 200 patientsRaksha M Patel
Department of Skin and V D, Medical College, Vadodara, Gujarat, India
Indian J Dermatol Venereol Leprol 74:430. 2008..Cutaneous drug reactions are the most common adverse reactions attributed to drugs. Any skin disorder can be imitated, induced or aggravated by drugs...
- Cutaneous reactions to drugs in childrenAlissa R Segal
Massachusetts College of Pharmacy and Health Sciences, Department of Pharmacy Practice, 179 Longwood Ave, Boston, MA 02115 5896, USA
Pediatrics 120:e1082-96. 2007..The purpose of this review is to discuss a reasonable approach to recognition and initial management of cutaneous adverse drug reactions in children...
- New advances in severe adverse drug reactionsJ Revuz
Department of Dermatology, Henri Mondor Hospital, Creteil, France
Dermatol Clin 19:697-709, ix. 2001..Usually the clinical pattern is well known and has been described in association with other drugs; new entities, however, are described frequently. This article reviews several of them...
- [Severe cutaneous drug reactions to celecoxib (Celebrex)]S Marques
Clinique Dermatologique, CHU Hotel Dieu, Nantes
Ann Dermatol Venereol 130:1051-5. 2003..Adverse reactions reported are usually benign, such as maculopapular exanthema. However, recently severe toxiderma have started to appear. We report two patients who developed a sever celecoxib drug skin reaction...
- Rash from antiepileptic drugs: influence by gender, age, and learning disabilitySilje Alvestad
Department of Neuroscience, Norwegian University of Science and Technology NTNU, Trondheim, Norway
Epilepsia 48:1360-5. 2007..We wanted to study the incidence of skin reactions of current AEDs and to explore their relation to clinical parameters such as gender, age, and learning disability...
- Correlation between rash and a positive drug response associated with bevacizumab in a patient with advanced colorectal cancerM Wasif Saif
Division of Medical Onclogy, Yale University School of Medicine, New Haven, CT 06520, USA
Clin Colorectal Cancer 7:144-8. 2008..To our knowledge, this case report is the second report of possible correlation between rash and a positive drug response associated with bevacizumab and warrants further investigation of similar observation...
- DRESS syndrome associated with carbamazepine and phenytoinJean Pierre Allam
Department of Dermatology, Friedrich Wilhelms University, Sigmund Freud Str 25 D 53105 Bonn, Germany
Eur J Dermatol 14:339-42. 2004..ECP blood levels may represent a sufficient parameter to monitor the development of DRESS syndrome...
- Mercury-induced acute generalized exanthematous pustulosis misdiagnosed as a drug-related caseHichem Belhadjali
Department of Dermatology, Fattouma Bourguiba Hospital, Monastir 500, Tunisia
Contact Dermatitis 59:52-4. 2008
- [Medical emergencies following dermatological injections and infusions]D Dill-Müller
Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum des Saarlandes, Homburg Saar
Hautarzt 57:195-201. 2006..5%. Every oncologic department should have an understanding of necrotic risk of the various agents and an emergency kit with instructions for immediate steps, also including agent-specific antidotes as available...
- Oral challenge in patients with suspected cutaneous adverse drug reactions: findings in 784 patients during a 25-year-periodKaija Lammintausta
Department of Dermatology, Turku University Central Hospital, Finland
Acta Derm Venereol 85:491-6. 2005..Out-patient protocol can be used in most cases...
- [Fluindione-induced acute generalised exanthematous pustulosis confirmed by patch testing]M Chtioui
Service de Dermatologie, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9, avenue Charles de Gaulle, 92100 Boulogne Billancourt, France
Ann Dermatol Venereol 135:295-8. 2008..Although fluindione is very widely prescribed in France, few cases of cutaneous drug reactions have been reported. Below we describe a case of acute generalised exanthematous pustulosis due to fluindione as confirmed by patch-testing...
- [Acute localized exanthematous pustulosis (ALEP)]Birte Prange
Hautklinik, Heinrich Heine Universitat Dusseldorf, Germany
J Dtsch Dermatol Ges 3:210-2. 2005..We report on a female patient who according to the criteria of AGEP was diagnosed as having acute localized exanthematic pustulosis (ALEP) on the face...
- Delayed hypersensitivity reactions to corticosteroidsS Cadinha
Serviço de Imunoalergologia, Hospital Sao Joao, Porto, Portugal
Allergol Immunopathol (Madr) 33:329-32. 2005..However, more and more cases of hypersensitivity reactions to CS have been described. Reports of delayed allergic reactions to CS in patients with asthma or allergic rhinitis are scarce...
- Acute generalized exanthematous pustulosis due to tetrazepamE Thomas
Allergy Department, Hospital La Paz, Madrid, Spain
J Investig Allergol Clin Immunol 18:119-22. 2008..These results support previous data suggesting an important role for IL-8 and drug-specific T cells in the pathogenesis ofAGEP and imply that the reaction was specific to tetrazepam with no cross-reactivity to other benzodiazepines...
- Ciprofloxacin-induced acute generalized exanthematous pustulosis mimicking bullous drug eruption confirmed by a positive patch testP Hausermann
Department of Dermatology, University Hospital Basel, Switzerland
Dermatology 211:277-80. 2005..Furthermore, we highlight in this particular case the challenging differentiation from bullous drug eruption...
- Drug hypersensitivity reactions: from clinical manifestations to an allergologic diagnosisS Bach
Allergy Unit, Department of Dermatology, University Hospital Basel, Switzerland
Eur Ann Allergy Clin Immunol 37:213-8. 2005
- Case of acute generalized exanthematous pustulosis caused by ampicillin/cloxacillin sodium in a pregnant womanYuka Matsumoto
Department of Dermatology, Tokyo Medical University, Tokyo, Japan
J Dermatol 35:362-4. 2008..To our knowledge, this is only the second case ever reported in the Japanese language published work of AGEP induced by ABPC/MCIPC...
- [Cutaneous drug reactions]Claus Lützow-Holm
Hudavdelingen, Ulleval universitetssykehus, 0407 Oslo
Tidsskr Nor Laegeforen 125:2483-7. 2005..Adverse cutaneous reactions to drugs are frequent in general practice. This article is a review of current knowledge of the pathogenesis, differential diagnosis and practical management of this wide spectrum of cutaneous manifestations...
- [Disseminated erythematous maculae with central bullae formation. Generalized fixed drug exanthema]Stefan Werner Schneider
Klinik und Poliklinik für Hautkrankheiten, Universitatsklinikum Munster
J Dtsch Dermatol Ges 2:143-6. 2004
- Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation testSylvia H Kardaun
Department of Dermatology, University Medical Center Groningen, University of Groningen, The Netherlands
J Am Acad Dermatol 55:S21-3. 2006..Best known are urticaria, erythema, and pruritus; sometimes pseudoallergic anaphylactoid reactions, and blisters are reported...
- [Adverse effects and safety of antimicrobial agents--allergy]Zenro Ikezawa
Department of Dermatology, Yokohama City University Graduate School of Medicine
Nihon Rinsho 65:578-86. 2007
- [The allergic and other side effects of non-steroid antiinflammatory drugs and gold salts]Lajos Attila Réthy
Magyar Tudományos Akademia Pécsi Tudományegyetem, Klinikai Genetikai Munkacsoport, Pecs
Orv Hetil 145:1943-9. 2004..Next to salicylates the most frequent side effects were caused by pyrazolon derivates. Urticaria and angioedema were the most frequently observed symptoms on the skin--our observations are in accordance with other publications...
- DRESS syndrome from cefadroxil confirmed by positive patch testM Hernanto
Department of Dermatovenereology, Faculty of Medicine, Gadjah Mada University, J1, Kesehatan No 1, Sekip Yogyakarta 55281, Indonesia
Allergy 62:1216-7. 2007
- Drug-induced linear immunoglobulin A bullous dermatosis mimicking Stevens-Johnson syndrome: a case reportJulie E Cummings
University of Texas Medical Branch, Galveston TX 77550, USA
Cutis 79:203-7. 2007..The patient's bullous eruption resolved with discontinuation of the offending medications and treatment with prednisone and pentoxifylline...
- [Allergy to antibiotics]A Hamzaoui
Pavillon B, Hôpital A Mami de Pneumologie, Ariana, Tunisie
Rev Mal Respir 23:10S70-10S72. 2006
- [Co-sensitization to drugs belonging to different chemical classes during the same episode of cutaneous adverse drug reaction: two cases]P Dellestable
Service de Dermatologie, Hopital Fournier, Nancy
Ann Dermatol Venereol 134:655-8. 2007....
- Polysensitivity in fixed drug eruption due to a novel drug combination-independent lesions due to piroxicam and cotrimoxazoleEsen Ozkaya
Eur J Dermatol 16:591-2. 2006
- Prevalence of drug allergy in an out-patient populationA G Palma-Carlos
Clinical Allergy Immunology Center, Lisbon, Portugal
Eur Ann Allergy Clin Immunol 38:142-5. 2006..Clinical history and skin tests are sufficient to diagnose most cases of drug allergy...
- Heliotrope-like eruption mimicking dermatomyositis in a patient treated with imatinib mesylate for chronic myeloid leukemiaYoshihiro Kuwano
Int J Dermatol 45:1249-51. 2006
- Allergological approach to drug hypersensitivity reactionsBernhard Przybilla
Klinik und Poliklinik fur Dermatologie und Allergologie, Ludwig Maximilians Universität Frauenlobstr 9 1180337 Munich, Germany
J Dtsch Dermatol Ges 6:240-3. 2008
- T-CELL MECHANISMS OF PATHOLOGY IN DTH & DRUG ERUPTIONSRichard Kalish; Fiscal Year: 1992..cutaneous pathology in allergic contact dermatitis to urushiol (Toxicodendron radicans, "poison ivy") and in drug eruptions. These conditions were chosen because the relevant antigen is known, lending them amenable to analysis...
- MECHANISMS OF CUTANEOUS INJURY IN LUPUS ERYTHEMATOSUSRichard Sontheimer; Fiscal Year: 1991..These studies might also yield insight into the pathogenesis of other related inflammatory skin diseases such as lichen planus, dermatomyositis and lichenoid drug eruptions.
- INNOVATIVE TUMOR TARGETED THERAPIES FOR LUNG CANCERRoman Perez Soler; Fiscal Year: 2004..Four such candidates have already been identified. It is anticipated that a total of ten young clinical investigators will be mentored during a five-year period. ..
- CATIONIC LIPID/P53 GENE THERAPY IN LUNG CANCER PATIENTSRoman Perez Soler; Fiscal Year: 2003..The results of this study will provide initial but very valuable information on the potential use of this new strategy in the treatment of bronchial premalignancy, carcinoma in situ, and endobronchial lung tumors. ..
- Determinants of Resistance to Erlotinib in NSCLCRoman Perez Soler; Fiscal Year: 2010..To confirm the predictive value of the algorithm in a group of patients with chemoresistant NSCLC selected for their high probability of achieving a response or stable disease with single agent erlotinib therapy. ..
- Chemotherapy and anti-EGFR Antibody C225 in Lung CancerRoman Perez Soler; Fiscal Year: 2004..abstract_text> ..
- Long-Circulating Liposomal Camptothecins CAP and EAPRoman Perez Soler; Fiscal Year: 2003..Ultimately, we will seek formulation(s) that display optimized drug retention and in vivo and in vitro performance. PROPOSED COMMERCIAL APPLICATION: Not Available ..
- Creatine: Is It a Body Builder for Cancer Patients?Aminah Jatoi; Fiscal Year: 2004..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
- Mechanisms and Therapeutics in Cancer Anorexia/CachexiaAminah Jatoi; Fiscal Year: 2004..This K23 grant application will serve as a springboard to allow her to delve into the pathophysiology of this syndrome and to develop into an independent clinical investigator. ..
- MIDCAREER INVESTIGATOR AWARD IN NEURO-AIDS RESEARCHDavid Simpson; Fiscal Year: 2005..The Neuro-Adherence Program will assess the affect of neurological disease on patients' adherence to medical regimens, and the impact of education and support groups on adherence. ..
- Nicotine Replacement Treatment for Pregnant SmokersCheryl Oncken; Fiscal Year: 2006..The odds of cigarette abstinence will be increased primarily in subjects who smoke at least 15 cigarettes per day...
- AFP-Based Immunotherapy for Hepatocellular CarcinomaAntoni Ribas; Fiscal Year: 2006..In summary, I propose a clinically-oriented research program that translates this original work into novel, evidence-based immnunotherapy trials for hepatocellular carcinoma. ..
- Dendritic Cell Vaccination During Lymphoid ReconstitutionJeffrey Weber; Fiscal Year: 2008..Toxicity as well as clinical response will be secondary endpoints. The cohort with the optimal level of immune response will be taken forward in future studies. ..
- Nitogen reduction and xenobiotic responseLauren A Trepanier; Fiscal Year: 2010..The ultimate goal of these studies is to find better ways to prevent these adverse reactions. ..
- Proactive Cessation Intervention with Biomarker FeedbackJENNIFER MC CLURE; Fiscal Year: 2008..If effective, this treatment strategy could have broad potential as a public health intervention. ..
- CTLA-4 Inhibition and Autoimmunity in MelanomaJeffrey Weber; Fiscal Year: 2008..abstract_text> ..
- Modulation of Iron Deposition in SCD and Other HemoglobinopathiesELLIOTT P contact VICHINSKY; Fiscal Year: 2010....
- Treatment decision making in older adults newly diagnosed with multiple myelomaJoseph D Tariman; Fiscal Year: 2010..Due to the limited studies in older adults with cancer, these specific aspects of decision-making have not been previously explored. ..
- Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized NeonatesAaron M Milstone; Fiscal Year: 2011..This project will help to develop evidence-based strategies to prevent bloodstream infections among vulnerable infants hospitalized in the neonatal intensive care unit. ..
- IL-12 as an Adjuvant for a Melanoma Peptide VaccineJeffrey Weber; Fiscal Year: 2003..The results of those assays will be used to design randomized phase III trials for resected high risk melanoma and to develop strategies for overcoming antigen-specific unresponsiveness in melanoma patients. ..
- PATHOGENESIS OF ANTICONVULSANT HYPERSENSITIVITY SYNDROMEJAMES LEEDER; Fiscal Year: 2003..It is anticipated that the basic experimental paradigm employed for these studies can also be applied to other idiosyncratic toxicities with suspected drug bioactivation and immune etiologies. ..
- IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMAJeffrey Weber; Fiscal Year: 2003....
- CBL FUNCTION IN CELLULAR SIGNALING AND TRANSFORMATIONBrian Druker; Fiscal Year: 2003..Through these studies the investigators should gain a greater understanding of the contribution of tyrosine phosphorylation of Cbl to its function and the role of Cbl in myeloid transformation. ..
- PREVENTIVE ONCOLOGY AWARD--SMOKING CESSATION AND WOMENJENNIFER MC CLURE; Fiscal Year: 2003..Such knowledge is important as it may lead to the development of more targeted, and therefore potentially more effective, cessation interventions. ..
- Therapeutic immune mechanisms of anti-CD11a in psoriasisJames Krueger; Fiscal Year: 2004..Following anti-CD1la we will look for reductions in 1) disease-associated T-cell activation, 2) Type 1 T-cells, and 3) abundance of specific, antigen-reactive T-cells in the peripheral circulation. ..
- HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIAJeffrey Weber; Fiscal Year: 2003..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
- Neuropeptide Y for Cancer-Associated AnorexiaAminah Jatoi; Fiscal Year: 2003..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..
- CHRONIC MYELOGENOUS LEUKEMIA AND BCR-ABL SUBSTRATESBrian Druker; Fiscal Year: 2009..Combined, these data should offer significant insights into the biology of and the mechanism of transformation by Bcr-Abl. ..
- PEDIATRIC BIPOLAR COLLABORATIVE MOOD STABILZER TRAILRobert Findling; Fiscal Year: 2003..Lastly, this trial will provide descriptive information on the stability of acute phase response to monotherapy over a 16 week continuation phase. ..
- Ontogeny of Drug Bioactivation and Idiosyncratic ADRsJAMES LEEDER; Fiscal Year: 2007..abstract_text> ..
- Cancer and KinasesBrian Druker; Fiscal Year: 2005..By facilitating the development of these drugs, we hope to improve the outcome for patients with cancer as rapidly as possible. ..
- Eighth Cooley's Anemia SymposiumElliott Vichinsky; Fiscal Year: 2005....
- SPECIAL POPULATIONS NETWORK FOR CANCER CONTROLEdith Mitchell; Fiscal Year: 2003..abstract_text> ..
- LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGEDNunzio Pomara; Fiscal Year: 2005..index of brain white matter organization) contribute most strongly to the acute effects of lorazepam on cognitive/motor performance or postural sway in elderly individuals receiving long-term lorazepam treatment for GAD? ..
- Therapeutic immune mechanisms of daclizumab in psoriasisJames Krueger; Fiscal Year: 2004..We will also measure the impact of daclizumab on T cell activation/deviation towards Type 2 T cells by sensitive flow cytometry based assays. ..
- Phase III Trial of Minocycline in ALS:I-Clinical CenterPaul Gordon; Fiscal Year: 2007..P.I. Dr. Robert Miller). ..
- Myostatin in Muscle Growth and RegenerationKathryn Wagner; Fiscal Year: 2005..In addition to the ultimate goal of providing clinical applications for muscle disease, this multidisciplinary approach should provide excellent training for a career integrating clinical myology and molecular neuroscience. ..
- E/BETA THALASSEMIA--NATURAL HISTORY & RESPONSE TO CHEMOElliott Vichinsky; Fiscal Year: 2002..In summary, if this study is successful, it will change the approach to Hb E/B worldwide and result in improved quality of life and decreased mortality. (End of Abstract) ..