contact dermatitis

Summary

Summary: A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.

Top Publications

  1. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
  2. pmc Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    M Pasparakis
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Exp Med 184:1397-411. 1996
  3. ncbi Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005
  4. ncbi Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model
    Patricia L Nadworny
    Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada
    Nanomedicine 4:241-51. 2008
  5. ncbi T cell- and B cell-independent adaptive immunity mediated by natural killer cells
    Jacqueline G O'Leary
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:507-16. 2006
  6. pmc CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses
    Donggou He
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 177:6852-8. 2006
  7. ncbi Mast cells as "tunable" effector and immunoregulatory cells: recent advances
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Immunol 23:749-86. 2005
  8. ncbi Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions
    A I Chen
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 11:689-98. 1999
  9. ncbi IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen
    Christina A Herrick
    Department of Dermatology and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 170:2488-95. 2003
  10. ncbi Th1 and type 1 cytotoxic T cells dominate responses in T-bet overexpression transgenic mice that develop contact dermatitis
    Kazusa Ishizaki
    Department of Anatomy and Embryology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Immunol 178:605-12. 2007

Detail Information

Publications280 found, 100 shown here

  1. ncbi Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells
    Adrien Kissenpfennig
    Centre d immunologie de Marseille Luminy, INSERM CNRS Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Immunity 22:643-54. 2005
    ..By using a similar knockin strategy involving a diphtheria toxin receptor (DTR) fused to EGFP, we demonstrated that LCs were dispensable for triggering hapten-specific T cell effectors through skin immunization...
  2. pmc Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    M Pasparakis
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Exp Med 184:1397-411. 1996
    ....
  3. ncbi Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity
    Daniel H Kaplan
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 23:611-20. 2005
    ..Moreover, we showed that LCs act during the priming and not the effector phase. Thus, LCs not only were dispensable for CHS, but they served to regulate the response, a previously unappreciated function...
  4. ncbi Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model
    Patricia L Nadworny
    Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada
    Nanomedicine 4:241-51. 2008
    The anti-inflammatory activity of nanocrystalline silver was examined using a porcine model of contact dermatitis. Inflammation was induced with dinitrochlorobenzene and then treated daily with nanocrystalline silver dressings, 0...
  5. ncbi T cell- and B cell-independent adaptive immunity mediated by natural killer cells
    Jacqueline G O'Leary
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:507-16. 2006
    ..These observations indicate that natural killer cells can mediate long-lived, antigen-specific adaptive recall responses independent of B cells and T cells...
  6. pmc CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses
    Donggou He
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 177:6852-8. 2006
    ..This indicates that CD8+ IL-17-producing cells are distinct from Tc1 cells and are important in effector functions at the elicitation of CHS. These studies provide insights into a novel mechanism for CHS...
  7. ncbi Mast cells as "tunable" effector and immunoregulatory cells: recent advances
    Stephen J Galli
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Immunol 23:749-86. 2005
    ....
  8. ncbi Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions
    A I Chen
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 11:689-98. 1999
    ..In vitro, Ox40L-deficient dendritic cells are defective in costimulating T cell cytokine production. Thus, Ox40L has a critical costimulatory function in vitro and in vivo for dendritic cell:T cell interactions...
  9. ncbi IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen
    Christina A Herrick
    Department of Dermatology and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 170:2488-95. 2003
    ....
  10. ncbi Th1 and type 1 cytotoxic T cells dominate responses in T-bet overexpression transgenic mice that develop contact dermatitis
    Kazusa Ishizaki
    Department of Anatomy and Embryology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Immunol 178:605-12. 2007
    b>Contact dermatitis in humans and contact hypersensitivity (CHS) in animal models are delayed-type hypersensitivity reactions mediated by hapten-specific T cells...
  11. ncbi Immediate contact skin reactions, an update of Contact Urticaria, Contact Urticaria Syndrome and Protein Contact Dermatitis -- "A Never Ending Story"
    Ana Gimenez-Arnau
    Department of Dermatology, Hospital del Mar, Universitat Autonoma de Barcelona, Passeig Maritim 25 29, 08003 Barcelona, Spain
    Eur J Dermatol 20:552-62. 2010
    ..Skin Reactions (ICSR) which manifest as Contact Urticaria Syndrome (CUS), Contact Urticaria (CU) and Protein Contact Dermatitis (PCD)...
  12. ncbi Mast cell-associated TNF promotes dendritic cell migration
    Hajime Suto
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:4102-12. 2006
    ..Our findings indicate that mast cell-associated TNF can contribute significantly to the initial stages of FITC-induced migration of cutaneous or airway DCs...
  13. pmc Dermal mast cells determine susceptibility to ultraviolet B-induced systemic suppression of contact hypersensitivity responses in mice
    P H Hart
    Department of Microbiology and Infectious Diseases, School of Medicine, Flinders University of South Australia, Adelaide, Australia 5001
    J Exp Med 187:2045-53. 1998
    ....
  14. pmc Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity
    Clare L Bennett
    Department of Cell Biology and Histology, Academic Medical Center AMC, University of Amsterdam, 1105 AZ Amsterdam, Netherlands
    J Cell Biol 169:569-76. 2005
    ..Our results establish Langerin-DTR mice as a unique tool to study LC function in the steady state and to explore their relative importance compared with dDC in orchestrating skin immunity and tolerance...
  15. ncbi The relationship between atopic dermatitis and contact dermatitis
    Arash Akhavan
    Department of Dermatology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Clin Dermatol 21:158-62. 2003
  16. ncbi Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models
    Eun Ah Bae
    Department of Food and Nutrition, Kyung Hee University, Hoegi, Dongdaemun ku, Seoul, Korea
    Biol Pharm Bull 29:1862-7. 2006
    ..KRGS) and its constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis (PCA) and contact dermatitis models were measured...
  17. pmc Impaired primary T cell responses in L-selectin-deficient mice
    J Xu
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Exp Med 183:589-98. 1996
    ..L-selectin does not appear to be rate limiting for the events leading to antigen-driven neutrophil recruitment, since normal DTH responses are obtained at late time points after immunization...
  18. ncbi Skin diseases with high public health impact. Contact dermatitis
    P J Coenraads
    Eur J Dermatol 17:564-5. 2007
  19. ncbi Cytokines and irritant contact dermatitis
    E Corsini
    Center for Cosmetic Toxicology, Institute of Pharmacological Sciences, University of Milan, Italy
    Toxicol Lett 102:277-82. 1998
    ..cellular immunity (IL-10, IL-12, IL-18). The role of cytokines in xenobiotics-induced skin irritation and the early molecular events that follow the treatment with irritant compounds will be discussed...
  20. ncbi [Contact dermatitis from polyacrylate in TENS electrode]
    F Weber-Muller
    Service de Dermatologie, Hopital Fournier, 36 quai de la Bataille, 54000 Nancy, France
    Ann Dermatol Venereol 131:478-80. 2004
    ..It induces few serious side effects, but skin reactions are not rare. We report on two cases of contact dermatitis due to TENS electrodes by sensitization to the acrylate in TENS conductive gel.
  21. ncbi Corticotropin-releasing factor receptor type 1 is involved in the stress-induced exacerbation of chronic contact dermatitis in rats
    Katsumi Kaneko
    Department of Physiology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Exp Dermatol 12:47-52. 2003
    ..of the corticotropin-releasing factor (CRF) receptor (CRFR) in stress-induced exacerbation of chronic contact dermatitis in rats...
  22. ncbi A novel treatment of contact dermatitis by topical application of phospholipase A2 inhibitor: a double-blind placebo-controlled pilot study
    A Ingber
    Int J Immunopathol Pharmacol 20:191-5. 2007
    ..In the present study we tested the effect of a novel PLA2 inhibitor on contact dermatitis in human subjects...
  23. ncbi Genetic basis of the effects of ultraviolet light B on cutaneous immunity. Evidence that polymorphism at the Tnfa and Lps loci governs susceptibility
    T Yoshikawa
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33136
    Immunogenetics 32:398-405. 1990
    ..We propose that the mechanism may function through the capacity of UVB to elicit excessive local (cutaneous) production of TNFa, which mediates the immune defect...
  24. ncbi Oxidative stress in allergic and inflammatory skin diseases
    Yoshimichi Okayama
    Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
    Curr Drug Targets Inflamm Allergy 4:517-9. 2005
    ..The present review summarizes the involvement of ROS in the pathogenesis of allergic and inflammatory skin diseases...
  25. ncbi Pacemaker contact dermatitis: The effective use of a polytetrafluoroethylene sheet
    Kensuke Ishii
    Department of Internal Medicine, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
    Pacing Clin Electrophysiol 29:1299-302. 2006
    ..9% titanium) after 72 hours. These findings indicated pacemaker contact dermatitis. After the patient was reimplanted with a pacemaker wrapped with a polytetrafluoroethylene sheet, there has ..
  26. ncbi Contact dermatitis in athletes
    Brett Kockentiet
    Department of Dermatology at Virginia Commonwealth University, Richmond, Virginia, USA
    J Am Acad Dermatol 56:1048-55. 2007
    ..unique and less well-defined genetically predisposing factors in the athlete's skin to cause both allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD)...
  27. ncbi Diagnosis and management of contact dermatitis
    Richard P Usatine
    University of Texas Health Science Center, San Antonion, Texas 78229, USA
    Am Fam Physician 82:249-55. 2010
    b>Contact dermatitis is a common inflammatory skin condition characterized by erythematous and pruritic skin lesions that occur after contact with a foreign substance. There are two forms of contact dermatitis: irritant and allergic...
  28. ncbi Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with allergic contact dermatitis
    Muradiye Nacak
    Department of Pharmacology, Faculty of Medicine, Mersin University, Mersin, Turkey
    Basic Clin Pharmacol Toxicol 101:101-3. 2007
    ..The purpose of the present study was to investigate the possible association between allergic contact dermatitis and insertion/deletion polymorphism of the ACE gene...
  29. ncbi Dissection of the role of paeoniflorin in the traditional Chinese medicinal formula Si-Ni-San against contact dermatitis in mice
    Yang Sun
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Han Kou Road, Nanjing 210093, China
    Life Sci 84:337-44. 2009
    ..In this study, we selectively deleted and replenished paeoniflorin from Si-Ni-San, a traditional Chinese prescription, and aimed to identify the molecular basis of how paeoniflorin exerted its effect in Si-Ni-San...
  30. ncbi Enhanced epidermal Langerhans cell migration in IL-10 knockout mice
    B Wang
    Division of Dermatology, Sunnybrook Health Science Center, University of Toronto, Ontario, Canada
    J Immunol 162:277-83. 1999
    ..These data suggest that IL-10 plays an inhibitory role in LC migration and that this effect may occur via the down-regulation of TNF-alpha and IL-1 production...
  31. ncbi Confocal histopathology of irritant contact dermatitis in vivo and the impact of skin color (black vs white)
    Shari P Hicks
    Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Acad Dermatol 48:727-34. 2003
    The pathogenesis of irritant contact dermatitis and its modulation according to skin color is not well understood. Reflectance confocal microscopy (RCM) enables high-resolution, real-time, in-vivo imaging of human skin.
  32. ncbi Contact dermatitis in car repair workers
    E Attwa
    Department of Dermatology and Venereology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    J Eur Acad Dermatol Venereol 23:138-45. 2009
    Occupational contact dermatitis (OCD) is a common skin disorder with a poor prognosis.
  33. ncbi 1,2-Ethanedithiol-induced erythema multiforme-like contact dermatitis
    Jeng Wei Tjiu
    Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
    Acta Derm Venereol 84:393-6. 2004
    b>Contact dermatitis simulating erythema multiforme can be caused by many allergens. The chemical agent 1,2-ethanedithiol, which serves as a protective group in chemical synthesis, has hitherto only been implicated as an irritant...
  34. ncbi Eumovate (clobetasone butyrate) 0.05% cream with its moisturizing emollient base has better healing properties than hydrocortisone 1% cream: a study in nickel-induced contact dermatitis
    A Parneix-Spake
    ASTER, Paris, France
    J Dermatolog Treat 12:191-7. 2001
    ..double-blind, intra-individual, comparative study that involved 18 volunteers with nickel-induced contact dermatitis. Following a positive patch test to nickel, sub-therapeutic amounts (10 micro l = 3 mg cm(-2)) of each of ..
  35. ncbi Systemic contact dermatitis to zinc in dental fillings
    T Shimizu
    Clin Exp Dermatol 28:675-6. 2003
  36. pmc Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity
    Regis A Campos
    Department of Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8013, USA
    J Exp Med 198:1785-96. 2003
    ....
  37. ncbi Guidelines for the management of contact dermatitis: an update
    J Bourke
    Department of Dermatology, South Infirmary, Victoria Hospital, Cork, Ireland
    Br J Dermatol 160:946-54. 2009
    These guidelines for management of contact dermatitis have been prepared for dermatologists on behalf of the British Association of Dermatologists...
  38. ncbi Prognosis and work absence due to occupational contact dermatitis
    A Adisesh
    Occupational Disease Intelligence Network, Centre for Occupational and Environmental Health, University of Manchester, Manchester, UK
    Contact Dermatitis 46:273-9. 2002
    The consequences of a diagnosis of occupational contact dermatitis (OCD) were investigated using cases available from the voluntary surveillance scheme, EPIDERM...
  39. ncbi Contact hypersensitivity: the mechanism of immune responses and T cell balance
    Hideaki Watanabe
    Department of Dermatology, Johns Hopkins University, Baltimore, MD 21287 0900, USA
    J Interferon Cytokine Res 22:407-12. 2002
    ..However, the conflicting opinions that continue to characterize discussions of CHS supply clear testimony that our knowledge is as yet incomplete...
  40. ncbi Anti-allergic effect of a combination of Citrus unshiu unripe fruits extract and prednisolone on picryl chloride-induced contact dermatitis in mice
    Tadashi Fujita
    School of Pharmacy, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka, 577 0818, Japan
    J Nat Med 62:202-6. 2008
    ..on type IV allergic reaction was examined by inhibitory activity of ear swelling of picryl chloride-induced contact dermatitis (PC-CD) in mice...
  41. ncbi Contact dermatitis and quality of life: a structured review of the literature
    R Skoet
    Department of Dermatology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark Psychooncology Research Unit, Aarhus University Hospital, Aarhus, Denmark
    Br J Dermatol 149:452-6. 2003
    ..QoL assessments in individuals with contact dermatitis are few. A structured review of the literature is presented...
  42. ncbi Langerin expressing cells promote skin immune responses under defined conditions
    Liangchun Wang
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:4722-7. 2008
    ..Overall, our results reconcile previous conflicting data in the literature, and suggest that Langerin(+) cells do promote T cell responses to skin Ags, but only under defined conditions...
  43. ncbi Predicting allergic contact dermatitis: a hierarchical structure-activity relationship (SAR) approach to chemical classification using topological and quantum chemical descriptors
    Subhash C Basak
    Natural Resources Research Institute, Center for Water and Environment, University of Minnesota, Duluth, 5013 Miller Trunk Hwy, Duluth, MN, 55811, USA
    J Comput Aided Mol Des 22:339-43. 2008
    A hierarchical classification study was carried out based on a set of 70 chemicals-35 which produce allergic contact dermatitis (ACD) and 35 which do not...
  44. ncbi Occupational contact dermatitis: etiology, prevalence, and resultant impairment/disability
    Donald V Belsito
    Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas 66160 7319, USA
    J Am Acad Dermatol 53:303-13. 2005
    Cutaneous irritant and allergic responses account for the vast majority of cases of occupational contact dermatitis (OCD)...
  45. ncbi The validity and reliability of the occupational contact dermatitis disease severity index
    Nathan Curr
    Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation Inc, Carlton South, Victoria, Australia
    Contact Dermatitis 59:157-64. 2008
    The occupational contact dermatitis disease severity index (ODDI) was designed to assess the severity and importantly the functional disability caused by occupational contact dermatitis (OCD) of the hands in patients attending our ..
  46. ncbi Comparative frequency of patch test reactions to topical antibiotics
    S D Morris
    St John s Institute of Dermatology, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Br J Dermatol 146:1047-51. 2002
    ..K., either as a single agent or in combination with topical corticosteroids. However, an adverse effect of topical antibiotics is contact sensitization...
  47. ncbi A retrospective analysis of contact allergy to lanolin
    S H Wakelin
    St John's Institute of Dermatology, London, UK
    Br J Dermatol 145:28-31. 2001
    ..CONCLUSIONS: This study illustrates that lanolin sensitization has remained at a relatively low and constant rate even in a high-risk population (i.e. patients with recent or active eczema)...
  48. pmc Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1
    J E Sligh
    Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX
    Proc Natl Acad Sci U S A 90:8529-33. 1993
    ..These mutant animals will be extremely valuable for examining the role of ICAM-1 and its counterreceptors in inflammatory disease processes and atherosclerosis...
  49. pmc Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2
    T Biedermann
    Department of Dermatology and Allergology, Ludwig Maximilians University Munich, 80337 Munich, Germany
    J Exp Med 192:1441-52. 2000
    ..Thus, mast cell-derived TNF and MIP-2 ultimately determine the pattern of infiltrating cells during T cell-mediated DTHRs...
  50. pmc The route of antigen entry determines the requirement for L-selectin during immune responses
    M D Catalina
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235 9072, USA
    J Exp Med 184:2341-51. 1996
    ....
  51. ncbi Airborne contact dermatitis due to Japanese cedar pollen
    Hiroo Yokozeki
    Department of Dermatology and Immunodermatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Contact Dermatitis 56:224-8. 2007
    b>Contact dermatitis caused by airborne antigen is a well-recognized problem. Previously, airborne contact dermatitis after contact with Japanese cedar pollen [Japanese cedar pollen dermatitis (JCPD)] has been reported in Japan...
  52. ncbi [Airbone contact dermatitis caused by latex exposure: a clinical case]
    L Proietti
    Dipartimento di Medicina Interna e Patologie Sistemiche, Sezione di Medicina del Lavoro, Universita degli Studi di Catania
    Clin Ter 157:341-4. 2006
    ..She worked as a attendant to a surgical chamber and wore vinyl gloves because of previous episodes of contact dermatitis caused by rubber gloves. The allergologic examination demonstrated that total IgE was 69...
  53. ncbi Contact dermatitis due to Allivum sativum and Ranunculus illyricus: two cases
    Muhterem Polat
    First Dermatology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey
    Contact Dermatitis 57:279-80. 2007
    ..Here we document two patients who developed contact dermatitis due to Allivum sativum, and Ranunculus illyricus after applying to the skin in order to relieve the ..
  54. ncbi An update on airborne contact dermatitis: 2001-2006
    Raquel Santos
    Department of Dermatology, Hospital de Curry Cabral, P 1069 166 Lisboa, Portugal
    Contact Dermatitis 57:353-60. 2007
    ..dermatologists and also occupational physicians have become increasingly aware of the airborne source of contact dermatitis, resulting mainly from exposure to irritants or allergens...
  55. ncbi Preformulation stability of Spantide II, a promising topical anti-inflammatory agent for the treatment of psoriasis and contact dermatitis
    Loice Kikwai
    Division of Pharmaceutics, College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, Florida, USA
    J Pharm Pharmacol 56:19-25. 2004
    Substance P is readily expressed in skin inflammatory disorders such as psoriasis and contact dermatitis. Spantide II is a peptide (MW 1668...
  56. ncbi [Orthopedic surgical implants and allergies: joint statement by the implant allergy working group (AK 20) of the DGOOC (German association of orthopedics and orthopedic surgery), DKG (German contact dermatitis research group) and dgaki (German society for
    P Thomas
    Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig Maximilians Universität München, Frauenlobstrasse 9 11, 80337 München, Deutschland
    Orthopade 37:75-88. 2008
    ..If a regular, potentially applicable CoCr/PE articulation is preferred, the patient must be well informed and must give his/her written consent...
  57. ncbi Differential requirements for interleukin (IL)-4 and IL-13 in protein contact dermatitis induced by Anisakis
    N Nieuwenhuizen
    IIDMM, University of Cape Town, South Africa
    Allergy 64:1309-18. 2009
    Exposure to antigens of the fish parasite Anisakis is associated with the development of protein contact dermatitis in seafood-processing workers...
  58. ncbi Contact dermatitis caused by pesticides among banana plantation workers in Panama
    Homero G Penagos
    Occupational Health Services, Occupational Dermatology Social Security Bureau, Panama
    Int J Occup Environ Health 8:14-8. 2002
    ..of the cases were related to exposures to fungicides; 246 with negative PPTs were classified as irritant contact dermatitis patients; 48 controls were negatives...
  59. ncbi Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response
    P L Chisholm
    Biogen, Inc, Cambridge Center, MA 02142
    Eur J Immunol 23:682-8. 1993
    ..These data are consistent with a central role for VLA-4 in the pathophysiologic process of inflammation...
  60. ncbi Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis
    M Kamsteeg
    Department of Dermatology, Biostatistics and Health Technology Assessment, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Br J Dermatol 162:568-78. 2010
    ..These genes are possible candidates for disease-specific pathogenetic changes, but could also provide a tool for molecular diagnostics of inflammatory skin conditions in general...
  61. ncbi Airborne contact dermatitis to methylchloroisothiazolinone/methylisothiazolinone in a boy
    Jens Michael Jensen
    Department of Dermatology, Allergology and Venerology, University Hospitals of Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
    Contact Dermatitis 55:311. 2006
  62. ncbi The role of IL-4, IL-10, and TNF-alpha in the immune suppression induced by ultraviolet radiation
    J M Rivas
    Department of Immunology, University of Texas, M D Anderson Cancer Center Houston 77030
    J Leukoc Biol 56:769-75. 1994
    ..Because anti-IL-4 and anti-IL-10 did not block the activity of the UV Ts that regulate contact hypersensitivity, their effects appear to be mediated by a different mechanism...
  63. ncbi Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207
    Patrizia Stoitzner
    Department of Dermatology, University of Innsbruck, Innsbruck, Austria
    J Invest Dermatol 120:266-74. 2003
    ....
  64. ncbi CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4+ and CD8+ T cells independently of IL-12
    Anton V Gorbachev
    Department of Immunology, Cleveland Clinic Foundation, OH 44195, USA
    J Immunol 173:2443-52. 2004
    ..These results indicate that hpLC stimulated by CD40 ligation use a mechanism distinct from increased IL-12 production to promote Ag-specific T cell development to IFN-gamma-producing cells...
  65. pmc B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity
    Ryohei F Tsuji
    Noda Institute for Scientific Research, Chiba ken 278, Japan
    J Exp Med 196:1277-90. 2002
    ..The IgM and challenge antigen likely form local complexes that activate complement, generating C5a, leading to local vascular activation to recruit the antigen-primed effector T cells that mediate the CS response...
  66. ncbi In vitro-generated regulatory T cells induced by Foxp3-retrovirus infection control murine contact allergy and systemic autoimmunity
    K Loser
    Department of Dermatology, University of Munster, Munster, Germany
    Gene Ther 12:1294-304. 2005
    ..Together, these findings indicate that newly in vitro-generated regulatory T cells can be successfully used to treat inflammatory and ongoing autoimmune disorders...
  67. ncbi Chemical activation of innate and specific immunity in contact dermatitis
    L Zhang
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    J Invest Dermatol 115:168-76. 2000
    Recent reports have suggested that chemical-induced allergic contact dermatitis may not be a traditional type IV hypersensitivity, in part due to the dual irritant and antigenic properties of sensitizing chemicals...
  68. ncbi The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance
    J E R Britton
    Department of Dermatology, The General Infirmary at Leeds, Leeds LS1 3EX, UK
    Br J Dermatol 148:259-64. 2003
    ..Objectives To assess the validity of the British standard series of 12 allergens used in addition to the 23 already in the European standard series...
  69. pmc Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response
    Atsushi Fukunaga
    Department of Immunology and Center for Cancer Immunology Research, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    J Immunol 180:3057-64. 2008
    ..These findings suggest that LC migration may not be responsible for the generation of contact hypersensitivity and that dermal dendritic cells may play a more important role...
  70. ncbi Hapten-induced contact hypersensitivity is enhanced in Tyk2-deficient mice
    Miwa Hosogi
    Biochemistry Laboratory, Pias Corporation, 1 3 1 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Dermatol Sci 36:51-6. 2004
    ..On the other hand, hapten-induced contact hypersensitivity (CHS) is mediated by IFN-gamma producing CD8+ T cells and regulated by CD4+ T cells...
  71. pmc Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice
    Maria Rosaria Cera
    Department of Vascular Biology, Italian Foundation for Cancer Research FIRC Institute of Molecular Oncology, Milan, Italy
    J Clin Invest 114:729-38. 2004
    ..Thus, we identified here a novel, non-redundant role of JAM-A in controlling DC motility, trafficking to lymph nodes, and activation of specific immunity...
  72. ncbi Nitric oxide appears to be a mediator of solar-simulated ultraviolet radiation-induced immunosuppression in humans
    Johanna M Kuchel
    Department of Medicine Dermatology, The Melanoma and Skin Cancer Research Institute, Royal Prince Alfred Hospital at the University of Sydney, Sydney, NSW 2006, Australia
    J Invest Dermatol 121:587-93. 2003
    ..Understanding the mechanisms of cutaneous ultraviolet-induced oxidative stress will assist in the future design of novel products that protect skin from photoaging and skin cancer...
  73. pmc Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses
    S Mori
    Department of Immunology, Toho University School of Medicine, Tokyo 143 8540, Japan
    J Exp Med 193:207-18. 2001
    ..These results demonstrate that plt mice mount robust T cell responses despite the failure of naive T cells and activated dendritic cells to enter the thymus dependent areas of secondary lymphoid organs...
  74. ncbi Fas-mediated inhibition of CD4+ T cell priming results in dominance of type 1 CD8+ T cells in the immune response to the contact sensitizer trinitrophenyl
    Stefan F Martin
    Clinical Research Group Allergology, Department of Dermatology, University of Freiburg, Germany
    J Immunol 173:3178-85. 2004
    ....
  75. ncbi Optical coherence tomography in contact dermatitis and psoriasis
    Julia Welzel
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Arch Dermatol Res 295:50-5. 2003
    ..In this study, it was used for the investigation of contact dermatitis and psoriasis...
  76. pmc Critical role of IL-10 in the induction of low zone tolerance to contact allergens
    Marcus Maurer
    Department of Dermatology, University of Mainz, Mainz, Germany
    J Clin Invest 112:432-9. 2003
    ..Thus, the generation of CD8+ LZT effector T cells by CD4+ regulatory T cells via IL-10 may be a promising target of strategies aimed at preventing contact allergies and other harmful immune responses...
  77. ncbi A high frequency of allergen-specific CD8+ Tc1 cells is associated with the murine immune response to the contact sensitizer trinitrophenyl
    Stefan Martin
    Clinical Research Group, Department of Dermatology, University of Freiburg, Freiburg, Germany
    Exp Dermatol 12:78-85. 2003
    ..These data suggest that allergies to chemical haptens may in part be due to an unusually high frequency of polyclonal, allergen-specific effector cells which are detected in all secondary lymphoid organs...
  78. ncbi Cytokine knockouts in contact hypersensitivity research
    Binghe Wang
    Department of Dermatology, School of Medicine, Johns Hopkins Medical Institutes, Johns Hopkins University, Outpatient Center Room 6068, 601 N, Caroline Street, Baltimore, MD 21287 0900, USA
    Cytokine Growth Factor Rev 14:381-9. 2003
    ..A variety of cytokine knockouts have been used to assign biological functions to specific cytokines in CHS. These studies have contributed significantly to our understanding of molecular mechanisms underlying CHS...
  79. pmc Epicutaneous immunization induces alphabeta T-cell receptor CD4 CD8 double-positive non-specific suppressor T cells that inhibit contact sensitivity via transforming growth factor-beta
    Marian Szczepanik
    Department of Human Developmental Biology, Jagellonian University College of Medicine, Krakow, Poland
    Immunology 115:42-54. 2005
    ....
  80. ncbi Comparative study on picryl chloride (PCL)-induced contact dermatitis in female IQI/Jic and BALB/c mice
    Ji Youn Jung
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Exp Anim 53:89-96. 2004
    Ear skin responses to picryl chloride (PCL)-induced contact dermatitis were compared in detail between IQI/Jic mice developed in Japan and BALB/c mice often used for the investigation of contact dermatitis...
  81. ncbi Diminished contact hypersensitivity response in IL-4 deficient mice at a late phase of the elicitation reaction
    B Weigmann
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Scand J Immunol 45:308-14. 1997
    ..The first phase proceeds efficiently in IL-4 deficient mice indicating the dependence on Th1/Tc1 cells, while the second phase does not develop in mice lacking IL-4, suggesting the possibility that Th2/Tc2 cells intensify the reaction...
  82. ncbi Nitric oxide participates in prick test and irritant patch test reactions in human skin
    J Wallengren
    Department of Dermatology, University Hospital, SE 221 85 Lund, Sweden
    Arch Dermatol Res 293:121-5. 2001
    ..were provoked with tuberculin (causing delayed immunologic reaction), benzalkonium chloride (irritant contact dermatitis), UV radiation or benzoic acid (nonimmunological contact urticaria)...
  83. ncbi Contact dermatitis due to para-phenylenediamine (PPD) on a temporal tattoo with henna. Cross reaction to azoic dyes
    Maria Cristina Di Prisco
    Instituto de Biomedicina MSDS UCV, Laboratorio de Inmunopatologia y Consulta de Alergia, Universidad Central de Venezuela Caracas, Venezuela
    Invest Clin 47:295-9. 2006
    ..fashion of applying temporal tattoos in occidental countries may produce an increase in the frequency of contact dermatitis due to henna mixtures with cross- reaction to related compounds and possibly producing permanent skin changes...
  84. pmc L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Med 181:2259-64. 1995
    ..These results demonstrate that L-selectin plays a prominent role in leukocyte homing to nonlymphoid tissues during inflammation and that blocking this process can be beneficial during pathological inflammatory responses...
  85. pmc Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice
    M Subramaniam
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 181:2277-82. 1995
    ..The results demonstrate a role for P-selectin in recruitment of CD4+ T lymphocytes and show that P-selectin plays a role in long-term inflammation as well as in acute responses...
  86. pmc Yes T cells, but three different T cells (alphabeta, gammadelta and NK T cells), and also B-1 cells mediate contact sensitivity
    P W Askenase
    Section of Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, CT 06510, USA
    Clin Exp Immunol 125:345-50. 2001
    ..Three of these four cell types are present in the immune lymphoid cell population that adoptively transfers CS: B-1 cells, gammadelta-T cells, and the alphabeta-T cells...
  87. ncbi The effect of physical and chemical properties of swimming pool water and its close environment on the development of contact dermatitis in hydrotherapists
    A Pardo
    Department of Occupational Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Ind Med 50:122-6. 2007
    The association between physical and chemical parameters in swimming pool water and the incidence of contact dermatitis (CD) in hydrotherapists was studied.
  88. ncbi Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity
    E Szabo
    Inotek Corporation, Beverly, Massachusetts, USA
    J Invest Dermatol 117:74-80. 2001
    ..Our results indicate that peroxynitrite and poly(ADP-ribose) polymerase regulate keratinocyte function and death in contact hypersensitivity...
  89. ncbi IL-12 augments CD8+ T cell development for contact hypersensitivity responses and circumvents anti-CD154 antibody-mediated inhibition
    A V Gorbachev
    Department of Immunology and Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 167:156-62. 2001
    ....
  90. pmc Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice
    P D Rennert
    Department of Immunology and Inflammation, Biogen, Incorporated, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Exp Med 193:1227-38. 2001
    ....
  91. ncbi The role of chemokines in allergic contact dermatitis
    Silvia Sebastiani
    Istituto Dermopatico dell Immacolata, IRCCS, Roma, Italy
    Arch Dermatol Res 293:552-9. 2002
    Chemokines are important mediators of immune-mediated skin diseases. Allergic contact dermatitis (ACD) is the most thoroughly investigated T cell-mediated disorder because of the ability to easily reproduce the lesions in humans and the ..
  92. ncbi Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata
    Kazumoto Katagiri
    Department of Anatomy, Biology and Medicine Dermatology, Faculty of Medicine, Oita University, Oita, Japan
    J Dermatol 33:75-9. 2006
    ..In this study, we investigated the anti-pruritic effect of the antihistamine, fexofenadine, on the itch of contact dermatitis that was induced by topical application of diphenylcyclopropenone for the treatment for alopecia areata...
  93. ncbi Immunological occupational contact urticaria and contact dermatitis from proteins: a review
    Cristina Amaro
    Department of Dermatology, Hospital de Curry Cabral, Rua da Beneficência, no 8, 1069 166 Lisbon, Portugal
    Contact Dermatitis 58:67-75. 2008
    ..contact with the skin can be associated with 2 major clinical conditions: contact urticaria and protein contact dermatitis. This article reviews the pathogenesis, clinical pictures and the literature on the proteins having caused ..
  94. ncbi [Contact dermatitis due to ethyl alcohol: how to perform patch tests?]
    A Barbaud
    Service de Dermatologie, Hopital Fournier, 36, quai de la Bataille, 54000 Nancy
    Ann Dermatol Venereol 127:484-7. 2000
    ..Ethyl alcohol sensitization is rare and can induce immediate contact urticaria or delayed eczema. Patch tests performed with ethanol can provoke an irritative reaction and are not well codified...
  95. ncbi Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity
    Yoko Takanami-Ohnishi
    Department of Biochemistry and Molecular Pharmacology, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    J Biol Chem 277:37896-903. 2002
    ..These results suggest that p38 plays a key role in CHS and is an important target for the treatment of CHS...
  96. ncbi Characterization of lymphocyte subpopulations and cytokine profiles in peripheral blood of nickel-sensitive individuals with systemic contact dermatitis after oral nickel exposure
    Christian Stab Jensen
    Department of Dermatology, Gentofte Hospital, Hellerup, Denmark
    Contact Dermatitis 50:31-8. 2004
    Several studies have shown that oral nickel exposure can elicit systemic contact dermatitis (SCD) in nickel-sensitive individuals...
  97. pmc Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity
    H Yokozeki
    Department of Dermatology, School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Exp Med 191:995-1004. 2000
    ..Our data suggest that the STAT6 signal plays a critical role in the induction phase of CHS...
  98. ncbi Occupational contact dermatitis in nurses with hand eczema
    R M Strauss
    Department of Dermatology, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
    Contact Dermatitis 44:293-6. 2001
    ..of 44 nurses with hand dermatitis (40 female, 4 male), 18 were thought to have a predominantly allergic contact dermatitis, 15 an irritant dermatitis, 7 other form of eczema, 3 atopic dermatitis and one pompholyx...
  99. ncbi Contact dermatitis of the hands: cross-sectional analyses of North American Contact Dermatitis Group Data, 1994-2004
    Erin M Warshaw
    Department of Dermatology, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    J Am Acad Dermatol 57:301-14. 2007
    Hand dermatitis, including irritant and allergic contact dermatitis (ACD), is common.
  100. ncbi Subunits of IgM reconstitute defective contact sensitivity in B-1 cell-deficient xid mice: kappa light chains recruit T cells independent of complement
    Vipin Paliwal
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Immunol 169:4113-23. 2002
    ..Thus, B-1 cell-mediated CS initiation required for T cell recruitment is due to activation of C by specific IgM pentamer, and also subunits of IgM, while kappa L chains act via another C-independent but mast cell-dependent pathway...
  101. ncbi CD1a-positive dendritic cells transport the antigen DNCB intracellularly from the skin to the regional lymph nodes in the induction phase of allergic contact dermatitis
    R E Hunger
    Dermatological Clinic, University of Berne, Switzerland
    Arch Dermatol Res 293:420-6. 2001
    ..These results provide direct evidence that during the induction phase of allergic contact dermatitis in humans antigen-bearing dendritic cells internalize the antigen and migrate from the skin via the afferent ..

Research Grants63

  1. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..and injury, acute systemic toxicity, dermal absorption, dermal corrosivity and irritation, allergic contact dermatitis, pyrogenicity, and vaccine potency...
  2. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..and injury, acute systemic toxicity, dermal absorption, dermal corrosivity and irritation, allergic contact dermatitis, pyrogenicity, and vaccine potency...
  3. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..Based on the fact that the small molecule Kv1.3 blocker PAP-1 also effectively suppresses allergic contact dermatitis (ACD) in rats when administered orally or topically, we now intend to explore the role of Kv1.3 in psoriasis...
  4. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..In proof-of-concept studies, Kv1.3 blockers prevent and/or treat disease in rat models of MS, T1DM, RA, contact dermatitis, delayed type hypersensitivity (DTH) and bone resorption associated with periodontitis...
  5. 3D Skin Model to Test Toxic and Sensitizing Potentials of Environmental Chemicals
    Akira Takashima; Fiscal Year: 2010
    ..Among many diseases caused by environmental chemicals, contact dermatitis is the leading disease in terms of the incidence - the CDC has listed contact dermatitis as one of the 21 ..
  6. Keratinocyte regulation of skin immunity
    Anthony A Gaspari; Fiscal Year: 2013
    ..We will utilize both human and mouse models of the common skin condition, allergic contact dermatitis (ACD). We selected this skin condition because it is a common skin disease in Veterans...
  7. The microglial potassium channels Kv1.3 and KCa3.1 as therapeutic targets for neu
    Heike Wulff; Fiscal Year: 2013
    ..compounds can prevent or treat various autoimmune diseases and inflammatory conditions in rodents such as contact dermatitis, type-1 diabetes, inflammatory bowel disease, atherosclerosis and EAE...
  8. Mechanisms used by skin dendritic cells to induce regulatory T cells
    Juliana Idoyaga; Fiscal Year: 2013
    ..e., atopic dermatitis, psoriais, contact dermatitis, and pemphigus vulgaris. Foxp3+ regulatory T cells (T regs) play a critical role in skin immunoregulation...
  9. Wireless Implantable Monitor for Improved Neuromodulation
    Margot S Damaser; Fiscal Year: 2012
    ..sphincter dyssynergia, leading to uncontrolled leakage of urine, putting the patient at increased risk for contact dermatitis and infected pressure ulcers...
  10. The Role of IL-6 Receptor in Irritant Dermatitis
    RANDLE MICHAEL GALLUCCI; Fiscal Year: 2013
    Of reported occupational injury associated with workman's compensation, contact dermatitis ranks second most prevalent over all...
  11. The role of IL-6 in jet fuel irritant dermatitis
    RANDLE MICHAEL GALLUCCI; Fiscal Year: 2010
    ..provided by applicant): Of reported occupational injury associated with workman's compensation, contact dermatitis ranks second most prevalent over all...
  12. Regulation of TSLP-Mediated Skin Inflammation
    Steven F Ziegler; Fiscal Year: 2013
    ..vulgaris, as well as allergic responses that lead to acute and chronic atopic dermatitis (AD) and allergic contact dermatitis (ACD)...
  13. Inhibitors of Fatty Acid Amide Hydrolase (FAAH)
    Dale L Boger; Fiscal Year: 2013
    ..clinical candidates for the treatment of pain, sleep disorders, and chronic inflammatory diseases including contact dermatitis, and multiple sclerosis...
  14. StrataScreenSENS, Skin Sensitizer Detection in Luminescent 3D Human Skin Models
    Cathy Rasmussen; Fiscal Year: 2012
    ..Allergic contact dermatitis (ACD) is a wide- spread public health problem resulting from exposure of human skin to certain reactive ..
  15. Peripheral Neural Mechanisms of Inflammatory Itch and Pain
    ROBERT H LA MOTTE; Fiscal Year: 2013
    ..The peripheral mechanisms of inflammatory itch and pain will be studied in a mouse model of allergic contact dermatitis (ACD) in humans...
  16. Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis
    Mahmoud A ElSohly; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Poison ivy/oak contact dermatitis is the most prevalent skin allergy in the United States, affecting >50% of the adult population...
  17. Barrier Function of Mammalian Skin Gordon Research Conference
    Theodora M Mauro; Fiscal Year: 2011
    ..specifically those that involve one of the epidermal barriers (for example, atopic dermatitis, ichthyosis, contact dermatitis, skin sun damage and skin infections)...
  18. 2013 Barrier Function of Mammalian Skin Gordon Research Conferences
    Theodora M Mauro; Fiscal Year: 2013
    ..specifically those that involve one of the epidermal barriers (for example, atopic dermatitis, ichthyosis, contact dermatitis, skin sun damage and skin infections)...
  19. Development of Topical Neuroinflammatory Inhibitors
    MANDIP SACHDEVA; Fiscal Year: 2005
    ..Certain skin diseases such as psoriasis, contact dermatitis and atopic dermatitis may have a significant neurogenic component...
  20. PATHOGENESIS OF ALLERGIC DISEASES OF THE SKIN & LUNGS
    Allen Kaplan; Fiscal Year: 1992
    ..of chronic urticaria will be compared to the vasculitis of cryoglobulinemia, late phase reactions, and contact dermatitis. Our assessment of hereditary angioedema will include new methods for diagnosis of the various types, ..
  21. Dermatological effects of gulf oil
    RANDLE MICHAEL GALLUCCI; Fiscal Year: 2013
    ..Diepgen, 2007) and of reported occupational injury associated with workman's compensation in the US, contact dermatitis ranks second most prevalent overall, affecting workers in all industries (Beltrani, 2003)...
  22. Keratinocyte Costimulation and Th2-Cell Immune Deviation
    Anthony Gaspari; Fiscal Year: 2009
    ..keratinocytes can contribute to the development of a skewed immune response to haptens that cause allergic contact dermatitis, promoting the emergence of Th2-1ymphocytes under circumstances when this type of Th-lymphocyte subset would ..
  23. Novel Topical Treatment of Eczema
    Bakul Bhatt; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Irritant and allergic contact dermatitis affect approximately 10% of adults, and hand eczema represents 1 of the 4 most common occupationally related diseases, accounting for substantial ..
  24. Vulvovaginal Skin Symptoms in Postmenopausal Women
    Elisabeth A Erekson; Fiscal Year: 2013
    ..questionnaire on vulvovaginal skin symptoms, adapted from a validated questionnaire for patients with contact dermatitis, and administered this questionnaire to 120 postmenopausal women seeking routine gynecologic care...
  25. MOLECULAR BASIS OF T CELL HOMING TO INFLAMED SKIN
    Louis Picker; Fiscal Year: 1999
    ..cells, and thus may participate in the pathogenesis of chronic inflammatory skin diseases, such as allergic contact dermatitis (ACD), atopic dermatitis (AD)...
  26. IRRITANTS EFFECTS ON EPIDERMAL ANTIGEN PRESENTATION
    Anthony Gaspari; Fiscal Year: 2002
    DESCRIPTION: (Adapted from the Investigator's Abstract) Irritant contact dermatitis (ICD) is a common and clinically important type of inflammatory skin disorder, and is thought to be the result of non-immunologic inflammation resulting ..
  27. QUANTIFICATION OF SKIN ACRYLATE ADDUCTS
    Leena Nylander French; Fiscal Year: 2000
    ..Abstract) Multifunctional acrylate are potent contact sensitizers and, thus, may cause allergic contact dermatitis and may promote skin cancer...
  28. Polymer Web Sensing System
    LEONID BUKSHPUN; Fiscal Year: 2007
    ..used to prevent skin contact with toxic chemicals, thousands of workers each year suffer from irritant contact dermatitis. To prevent injuries by warning workers before toxic chemicals break through PCC, a fast-responding chemical ..
  29. GENETIC FINGERPRINTS OF IRRITANT CONTACT DERMATITIS
    Paul Bergstresser; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the Investigator's Abstract) Irritant contact dermatitis is an important cause of morbidity and time loss in occupational and home environments...
  30. IMMUNOMODULATION OF CUTANEOUS ENDOTHELIAL CELLS BY A-MSH
    Cheryl Armstrong; Fiscal Year: 1999
    ..inflammation generated in three distinct murine models of common cutaneous inflammatory diseases: allergic contact dermatitis, irritant dermatitis, and acute photodermatitis in wild type and genetically altered animals...
  31. CONFOCAL HISTOPATHOLOGY OF CONTACT DERMATITIS IN VIVO
    Salvador Gonzalez; Fiscal Year: 2002
    The overall goal of this work is to establish new criteria to differentiate acute Irritant Contact Dermatitis (ICD) from Allergic Contact Dermatitis (ACD) by using a video rate (real-time), near-infrared confocal reflectance microscope (..
  32. Novel Skin Barrier to Prevent and Treat Poison Ivy
    Charles Gauntt; Fiscal Year: 2004
    Poison ivy/oak dermatitis (also known as Toxicodendron dermatitis) is the most common allergic contact dermatitis in the United States, affecting millions of Americans every year...
  33. NOVEL ANGIOGENIC CYTOKINE INDUCED ENDOTHELIAL ANTIGEN
    Alisa Koch; Fiscal Year: 2002
    ..and is upregulated in human RA synovial tissue lining affected joints and in a human poison ivy model of contact dermatitis. Moreover, the antigen detected by monoclonal antibody 4A11 is contained in both Lewisy-6 (Ley) and H-5-2 (H-..
  34. Hairdresses' Health Study
    KAREN HUYCK; Fiscal Year: 2009
    ..exposed to many risk factors for occupational diseases such as asthma and other respiratory disorders, contact dermatitis, poor work posture, repetitive work tasks, adverse reproductive outcomes, and cancer...
  35. Experimental and Clinical Contact Dermatitis Meetings
    Kevin Cooper; Fiscal Year: 2002
    This proposal requests support for the third meeting of the Experimental Contact Dermatitis Research Group (ECDRG)...
  36. MECHANISMS OF CYTOSKELETAL INJURY BY NI COMPOUNDS
    Ken Lin; Fiscal Year: 1990
    ..of industries, is a well documented carcinogen as well as a potent skin sensitizer causing severe allergic contact dermatitis. Thus, the causal role of Ni compounds as occupational hazards is significant...
  37. T-CELL MECHANISMS OF PATHOLOGY IN DTH & DRUG ERUPTIONS
    Richard Kalish; Fiscal Year: 1992
    ..The goal of this project is to determine the mechanisms of lymphocyte mediated cutaneous pathology in allergic contact dermatitis to urushiol (Toxicodendron radicans, "poison ivy") and in drug eruptions...
  38. ASSAY FOR HAPTEN SPECIFIC PRIMING OF T LYMPHOCYTES
    J Streilein; Fiscal Year: 1999
    DESCRIPTION: (Adapted from the Investigator's Abstract) Allergic and irritant contact dermatitis (ACD and ICD) are common inflammatory skin conditions that result after exposure of the cutaneous surface to certain environmental agents (..
  39. International Symposium on Atopic Dermatitis
    Jon Hanifin; Fiscal Year: 2001
    ..of atopic disease on the prevalence, incidence, and costs of occupational dermatoses, specifically allergic contact dermatitis/hand eczema; 6) Improve the public awareness regarding the scope and prevalence of AD and the range of ..
  40. Topical Cyclosporin A for Dermatitis and Psoriasis
    Jonathan Rothbard; Fiscal Year: 2001
    ..their ability to inhibit secretion of Il-2 by activated T cells and in vivo using an animal model of contact dermatitis. PROPOSED COMMERCIAL APPLICATION: Current topical therapies for dermatitis and psoriasis all have ..
  41. In Vitro Assay For Chemical Allergens
    Seyoum Ayehunie; Fiscal Year: 2009
    Allergic contact dermatitis (ACD) is one of the most common and costly health problems in industrialized countries...
  42. CHARACTERIZATION AND CULTURE OF HUMAN LANGERHANS CELLS
    Vera Morhenn; Fiscal Year: 1991
    ..Although these cells have been implicated as playing a major role in contact dermatitis, probably by acting as antigen presenting cells, their exact function(s), in particular their secretory ..
  43. SKIN DISEASES RESEARCH CORE CENTER
    Paul Bergstresser; Fiscal Year: 2005
    ..has brought distinguished scientists to provide seminars, and co-sponsored an international symposium on contact dermatitis; and (1) endowment that has supplemental SDRC funds, thus partially achieving self-sustenance and greater ..
  44. OCCUPATIONALLY-INDUCED ISOCYANATE REACTIONS
    I Bernstein; Fiscal Year: 1980
    ..In addition, induction of contact dermatitis by various isocyanate compounds, applied directly to guinea pigs' skin will also be attempted...
  45. NEURO MICROVASCULAR MECHANISMS IN SKIN INFLAMMATION
    JOHN ANSEL; Fiscal Year: 2001
    ..Third is to determine the role of DMEC-mediated neurogenic inflammation in the pathogenesis of animal models of allergic contact dermatitis, irritant dermatitis, and acute photodermatitis.
  46. Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis
    Mahmoud Elsohly; Fiscal Year: 2006
    ..at the development of new composition(s) to be used for the prophylactic treatment/prevention of poison ivy contact dermatitis in sensitive individuals...
  47. In Vitro Assay For Chemical Allergens
    Seyoum Ayehunie; Fiscal Year: 2004
    Allergic contact dermatitis (ACD) is one of the most common and costly health problems in industrialized countries...
  48. Reconstruction of skin model containing Langerhans cells
    Seyoum Ayehunie; Fiscal Year: 2003
    ..2 cytokines known to be critically involved in the initial stages of allergic contact dermatitis (ACD). Exposure to the common irritant, on the other hand, did not result in TNF-a or IL- lb release...
  49. CUTANEOUS BIOLOGY OF KIT LIGAND
    JACK LONGLEY; Fiscal Year: 2005
    ..These studies will determine specific contributions of SCF-KIT signaling to contact dermatitis, an provide support for the hypothesis that inhibitors of KIT may be novel therapeutic agents for human ..
  50. Immortized Human Langerhans Cells
    Seyoum Ayehunie; Fiscal Year: 2002
    ..a highly differentiated skin model and the capacity of such an immuno-competent model to predict allergic contact dermatitis will be studied...
  51. UV-induced Immunosuppression to chemical toxicants
    Kevin Cooper; Fiscal Year: 2006
    ..Thus, an allergic contact dermatitis (ACD) skin reaction to a chemical environmental agent alone can be converted into an immune suppressed state ..
  52. REGULATION OF THE IMMUNE RESPONSE TO CONTACT ALLERGENS
    Henry Maguire; Fiscal Year: 1980
    The flare reaction in allergic contact dermatitis is an activation (inflammation) of old ACD challenge sites when the allergen is given parenterally...
  53. SKIN CANCER--IMMUNOTOXIC MECHANISMS
    Craig Elmets; Fiscal Year: 1991
    ..This will be accomplished by inducing a contact dermatitis reaction in mice to two polyaromatic hydrocarbons, 7,12- dimethylbenz(a)anthracene (DMBA) and benzo(a)pyrene ..
  54. ALLERGIC CONTACT DERMATITIS: MECHANISMS OF ELICITATION
    Hui Xu; Fiscal Year: 2008
    Allergic contact dermatitis is a T-cell mediated cutaneous inflammatory disease caused by epicutaneous exposure to reactive haptens...
  55. THE ROLE OF IL-17 PRODUCING T LYMPHOCYTES IN ALLERGIC CONTACT DERMATITIS
    Hui Xu; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): Allergic contact dermatitis (ACD) is a T cell mediated cutaneous inflammatory disease caused by epicutaneous exposure to reactive allergens...
  56. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2008
    ..These initiating processes occur in the murine model of allergic contact dermatitis, and in a related model of occupational asthma involving hapten elicitation of airway hyperreactivity (AHR) ..
  57. Generation and Analysis of Langerhans Cell Null Mice
    Daniel Kaplan; Fiscal Year: 2008
    ..This proposed 5 year mentored program will allow me to develop a unique model system that will provide the basis for many long term projects and collaborations and further my development into an independent investigator. ..
  58. Non-Invasive Imaging of T Cell Trafficking
    Bernd Pichler; Fiscal Year: 2006
    ..abstract_text> ..
  59. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  60. Gender differences in liver IL-6R expression
    RANDLE GALLUCCI; Fiscal Year: 2007
    ..By exposing ethanol- consuming rats to IL-6R agonists, it should be possible to correlate damage with receptor activation. [unreadable] [unreadable] [unreadable]..
  61. CLA as a Mediator of Human Prostate Tumor Metastasis
    CHARLES DIMITROFF; Fiscal Year: 2005
    ..These studies will help reveal the importance of E-selectin ligand(s), namely CLA, in mediating the migration of human prostate tumor cells to bone and stimulate the development of novel anti-metastatic therapeutics, such 4-F-GIcNAc. ..