cicatrix

Summary

Summary: The formation of new tissue in the process of wound healing.

Top Publications

  1. pmc Scarless fetal wound healing: a basic science review
    Barrett J Larson
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Plast Reconstr Surg 126:1172-80. 2010
  2. ncbi Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony
    James A White
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Am Coll Cardiol 48:1953-60. 2006
  3. pmc Scar-free healing: from embryonic mechanisms to adult therapeutic intervention
    Mark W J Ferguson
    UK Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 359:839-50. 2004
  4. pmc Conjunctival transcriptome in scarring trachoma
    Matthew J Burton
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 79:499-511. 2011
  5. ncbi Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies
    Mark W J Ferguson
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Lancet 373:1264-74. 2009
  6. ncbi Incidence of post-pyelonephritic renal scarring: a meta-analysis of the dimercapto-succinic acid literature
    William C Faust
    Georgetown University School of Medicine, Washington, DC, USA
    J Urol 181:290-7; discussion 297-8. 2009
  7. ncbi Predictors of renal scar in children with urinary infection and vesicoureteral reflux
    Alper Soylu
    Department of Pediatrics, Dokuz Eylul University Medical Faculty, Izmir, Turkey
    Pediatr Nephrol 23:2227-32. 2008
  8. ncbi Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice
    Jessica A Manuel
    Regenerative Biology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Matrix Biol 25:505-14. 2006
  9. ncbi IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation
    William H Peranteau
    Department of Surgery, The Center for Fetal Research, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Invest Dermatol 128:1852-60. 2008
  10. ncbi Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery
    Nicole Klapka
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Eur J Neurosci 22:3047-58. 2005

Research Grants

  1. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
  2. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
  3. Visual outcomes & quality of life in CMV retinitis
    Jennifer Thorne; Fiscal Year: 2006
  4. CLINICAL RESEARCH CURRICULUM
    Karla Zadnik; Fiscal Year: 2004
  5. Vision Research--Biostatistics and Epidemiology Module
    Karla Zadnik; Fiscal Year: 2007
  6. OPTOMETRY COORDINATING CENTER
    Karla Zadnik; Fiscal Year: 2002
  7. COLLABORATIVE LONGITUDINAL EVALUATION KERATOCONUS STUDY
    Karla Zadnik; Fiscal Year: 2004
  8. Microarray Analysis of Wounds
    AMY COLWELL; Fiscal Year: 2004
  9. Cicatricial alopecia Colloquium
    Paradi Mirmirani; Fiscal Year: 2005
  10. Molecular Analysis of Scarless Fetal Wound Healing
    Sandeep Kathju; Fiscal Year: 2007

Detail Information

Publications280 found, 100 shown here

  1. pmc Scarless fetal wound healing: a basic science review
    Barrett J Larson
    Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Plast Reconstr Surg 126:1172-80. 2010
    ..These differences may have important implications in scarless wound repair...
  2. ncbi Delayed enhancement magnetic resonance imaging predicts response to cardiac resynchronization therapy in patients with intraventricular dyssynchrony
    James A White
    Division of Cardiology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    J Am Coll Cardiol 48:1953-60. 2006
    ..We evaluated the ability of delayed enhancement magnetic resonance imaging (DE-MRI) to predict clinical response to cardiac resynchronization therapy (CRT)...
  3. pmc Scar-free healing: from embryonic mechanisms to adult therapeutic intervention
    Mark W J Ferguson
    UK Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, 3 239 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 359:839-50. 2004
    ....
  4. pmc Conjunctival transcriptome in scarring trachoma
    Matthew J Burton
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Infect Immun 79:499-511. 2011
    ....
  5. ncbi Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies
    Mark W J Ferguson
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Lancet 373:1264-74. 2009
    ..Research into mechanisms of skin scarring identified transforming growth factor beta3 (TGFbeta3) as a potential antiscarring therapy. We assessed scar improvement with avotermin (recombinant, active, human TGFbeta3)...
  6. ncbi Incidence of post-pyelonephritic renal scarring: a meta-analysis of the dimercapto-succinic acid literature
    William C Faust
    Georgetown University School of Medicine, Washington, DC, USA
    J Urol 181:290-7; discussion 297-8. 2009
    ..We investigated ethnic differences in the risk of post-pyelonephritic renal scarring in infants and children for possible genetic determinants...
  7. ncbi Predictors of renal scar in children with urinary infection and vesicoureteral reflux
    Alper Soylu
    Department of Pediatrics, Dokuz Eylul University Medical Faculty, Izmir, Turkey
    Pediatr Nephrol 23:2227-32. 2008
    ....
  8. ncbi Matrix metalloproteinase 9 (MMP-9) is upregulated during scarless wound healing in athymic nude mice
    Jessica A Manuel
    Regenerative Biology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Matrix Biol 25:505-14. 2006
    ..This data suggest that MMP-9 expression in the remodeling phase of wound healing in nude mice could be a major component of their ability for scar-free healing...
  9. ncbi IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation
    William H Peranteau
    Department of Surgery, The Center for Fetal Research, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    J Invest Dermatol 128:1852-60. 2008
    ..We conclude that lentivirus-mediated overexpression of IL-10 decreases the inflammatory response to injury, creating an environment conducive for regenerative adult wound healing...
  10. ncbi Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery
    Nicole Klapka
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Eur J Neurosci 22:3047-58. 2005
    ....
  11. ncbi Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance
    Andrew S Flett
    Department of Cardiology, The Heart Hospital, University College London Hospitals NHS Trust, London, UK
    JACC Cardiovasc Imaging 4:150-6. 2011
    ....
  12. ncbi Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex
    Yu Wang
    Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Exp Neurol 203:168-84. 2007
    ..Thus, our experiments suggest that TGF-beta signaling through Smad3 contributes significantly to the immune response and scar formation after cortical stab wound injury, delaying recovery through multiple mechanisms...
  13. ncbi Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord
    C Lagord
    Department of Medicine, Wolfson Research Laboratories, Queen Elizabeth Medical Centre, University of Birmingham, Edgbaston, United Kingdom
    Mol Cell Neurosci 20:69-92. 2002
    ..The cellular localization and temporal pattern of expression of TGFbeta after spinal cord injury suggest that TGFbeta1 modulates the inflammatory and neuronal responses, while TGFbeta2 regulates glial/collagen scarring...
  14. ncbi Beta-catenin signaling in fibroproliferative disease
    Erin Bowley
    Cell and Molecular Biology Laboratory of the Hand and Upper Limb Centre, London, Ontario, Canada
    J Surg Res 138:141-50. 2007
    ..Beta-catenin has been historically recognized as both an intermediate in the "canonical Wnt signaling pathway" and as a component of functional adherens junctions...
  15. pmc GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism
    Mohit Kapoor
    Division of Oral Biology and Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    J Clin Invest 118:3279-90. 2008
    ..These results suggest that targeting the GSK-3beta pathway or ET-1 may be of benefit in controlling tissue repair and fibrogenic responses in vivo...
  16. pmc Skin scarring
    A Bayat
    Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Wythenshawe Hospital, Wythenshawe, Manchester M23 9LT, UK
    BMJ 326:88-92. 2003
  17. pmc Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia
    J P Sundberg
    Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Am J Pathol 156:2067-75. 2000
    ....
  18. ncbi The collagenous lesion scar--an obstacle for axonal regeneration in brain and spinal cord injury
    S Hermanns
    Molecular Neurobiology Laboratory, Department of Neurology, , Moorenstr. 5, , Germany
    Restor Neurol Neurosci 19:139-48. 2001
    ..This review will focus on the collagenous wound healing scar, discuss its composition and summarize the experimental results that demonstrate its role in the failure of axonal regeneration in the injured mammalian CNS...
  19. pmc A new in vitro model of the glial scar inhibits axon growth
    Ina B Wanner
    Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, USA
    Glia 56:1691-709. 2008
    ..c) 2008 Wiley-Liss, Inc...
  20. ncbi Novel antisense oligonucleotides targeting TGF-beta inhibit in vivo scarring and improve surgical outcome
    M F Cordeiro
    Department of Pathology and Glaucoma, London, UK
    Gene Ther 10:59-71. 2003
    ..Furthermore, although we have shown this agent to be useful in the eye, it could have widespread applications anywhere in the body where the wound-healing response requires modulation...
  21. pmc Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury
    J Frisen
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Cell Biol 131:453-64. 1995
    ....
  22. ncbi The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair
    Brian M Stramer
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK
    J Invest Dermatol 127:1009-17. 2007
    ....
  23. ncbi Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
    Jonathan A Fallowfield
    Liver Research Group, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 178:5288-95. 2007
    ..Thus, SAMs selectively, during resolution of fibrosis induce and use the major collagenase MMP13 to mediate the resorption of interstitial matrix and successfully remodel the fibrotic liver...
  24. pmc A coding polymorphism in matrix metalloproteinase 9 reduces risk of scarring sequelae of ocular Chlamydia trachomatis infection
    Angels Natividad
    London School of Hygiene and Tropical Medicine, London University, London, UK
    BMC Med Genet 7:40. 2006
    ..Genetic variation within the MMP9 gene affects in vitro MMP9 expression levels, enzymatic activity and susceptibility to various inflammatory and fibrotic conditions...
  25. ncbi Regeneration beyond the glial scar
    Jerry Silver
    Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Neurosci 5:146-56. 2004
  26. ncbi Left atrial function and scar after catheter ablation of atrial fibrillation
    John V Wylie
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Heart Rhythm 5:656-62. 2008
    ..Catheter ablation of atrial fibrillation (AF) involves extensive radiofrequency ablation (RFA) of the left atrium (LA) around the pulmonary veins. The effect of this therapy on LA function is not fully characterized...
  27. pmc Quiescent keratocytes fail to repair MMC induced DNA damage leading to the long-term inhibition of myofibroblast differentiation and wound healing
    James V Jester
    Gavin Herbert Eye Institute, University of California Irvine, CA, USA
    Mol Vis 18:1828-39. 2012
    ..The purpose of this study was to determine the acute and long-term effects of mitomycin C (MMC) on quiescent rabbit corneal keratocytes regarding cell proliferation, myofibroblast differentiation and DNA repair...
  28. ncbi Scar myofibroblasts of the infarcted rat heart express natriuretic peptides
    Angelino Calderone
    Department of Physiology, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada
    J Cell Physiol 207:165-73. 2006
    ..Constitutive and sympathetic-driven natriuretic peptide synthesis by myofibroblasts may in part influence reparative fibrosis...
  29. ncbi Scarless fetal wounds are associated with an increased matrix metalloproteinase-to-tissue-derived inhibitor of metalloproteinase ratio
    Catherine M Dang
    Department of Surgery, School of Medicine, University of California, Los Angeles, 90095, USA
    Plast Reconstr Surg 111:2273-85. 2003
    ..E16 scarless wounds have greater MMP relative to TIMP expression than E19 scarring wounds. This favors extracellular matrix turnover, facilitates migration of fetal cells, and promotes scarless repair...
  30. ncbi Long-term cosmetic results after minimally invasive video-assisted thyroidectomy
    Maik Sahm
    Department of Surgery, DRK Kliniken Berlin Köpenick, Berlin, Germany
    Surg Endosc 25:3202-8. 2011
    ..g. the question of keloids) cannot be documented during the inpatient stay. This report describes the long-term cosmetic results for this method and analyzes the subjective and objective outcomes after MIVAT...
  31. pmc Innate immune responses and modified extracellular matrix regulation characterize bacterial infection and cellular/connective tissue changes in scarring trachoma
    Victor H Hu
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    Infect Immun 80:121-30. 2012
    ..This study supports the possibility that the immunofibrogenic response in scarring trachoma is partly stimulated by nonchlamydial bacterial infection, which is characterized by the expression of innate factors...
  32. pmc Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions
    Kevin P Horn
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 28:9330-41. 2008
    ..Our data are the first to indicate a direct role of activated macrophages in axonal retraction by physical cell-cell interactions with injured axons...
  33. ncbi Small molecule inhibitor of type I transforming growth factor-β receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons
    Nozomu Yoshioka
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Neurosci Res 89:381-93. 2011
    ..These results indicate that inhibition of TGF-β signaling suppresses formation of the fibrotic scar and creates a permissive environment for axonal regeneration...
  34. ncbi High grade primary vesicoureteral reflux in boys: long-term results of a prospective cohort study
    Basim S Alsaywid
    Urology Department, Children s Hospital at Westmead and Discipline of Imaging and Paediatrics, Sydney, New South Wales, Australia
    J Urol 184:1598-603. 2010
    ....
  35. ncbi Novel therapies for scar reduction and regenerative healing of skin wounds
    J Matthew Rhett
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA
    Trends Biotechnol 26:173-80. 2008
    ..Lessons learned in promoting scarless healing of cutaneous injuries might provide a basis for regenerative healing in other scenarios, such as spinal cord rupture or myocardial infarction...
  36. ncbi Use of Patient and Observer Scar Assessment Scale for evaluation of facial scars treated with self-drying silicone gel
    Francesca A Bianchi
    Division of Maxillofacial Surgery, Head and Neck Department, San Giovanni Battista Hospital, Turin, Italy
    J Craniofac Surg 21:719-23. 2010
    ..The only item in the OS that underwent no change from T0 to T1 was surface area. The POSAS revealed satisfactory healing of posttraumatic and surgical facial scars that were treated with self-drying silicone gel...
  37. pmc Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy
    Kenneth C Bilchick
    Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    JACC Cardiovasc Imaging 1:561-8. 2008
    ....
  38. ncbi Expression of transforming growth factor-beta receptors in meningeal fibroblasts of the injured mouse brain
    Yukari Komuta
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, 183 8526, Japan
    Cell Mol Neurobiol 30:101-11. 2010
    ..These results indicate that meningeal fibroblasts not reactive astrocytes are a major target of TGF-beta1 that is upregulated after CNS injury...
  39. ncbi Keratinocyte regulation of TGF-beta and connective tissue growth factor expression: a role in suppression of scar tissue formation
    Syed Basith Amjad
    University Department of Surgical Paediatrics, Royal Hospital for Sick Children, Yorkhill, Glasgow, United Kingdom
    Wound Repair Regen 15:748-55. 2007
    ..Fibroblasts stained strongly for TGF-beta1 and 3 and CTGF. These observations suggest that keratinocytes may affect the TGF-beta profile in such a way as to suppress the formation of scar tissue...
  40. ncbi Collagen matrix in spinal cord injury
    Nicole Klapka
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    J Neurotrauma 23:422-35. 2006
    ..Therapeutic treatments aiming at suppression of fibrous scarring have been shown to promote axon regeneration in various lesion paradigms of the mammalian CNS...
  41. ncbi Is surgery an effective and adequate treatment in advanced Marjolin's ulcer?
    Eser Aydogdu
    Dr Lütf Kirdar Kartal Education and Research Hospital, Plastic and Reconstructive Surgery Department, Yaliyolu Emanet Sok Telatar Apt, 49 9 Bostanci Istanbul, Turkey
    Burns 31:421-31. 2005
    ..An aggressive combined approach is essential for treatment in early stages with high success rate. But there is no consensus for the treatment of advanced disease and results are generally unsuccessful...
  42. ncbi Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine
    Dai Shi Tian
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    J Neurosci Res 84:1053-63. 2006
    ..In the future, therapeutic strategies can be designed to achieve efficient axonal regeneration and functional compensation after traumatic CNS injury...
  43. ncbi The hidden cost of skin scars: quality of life after skin scarring
    B C Brown
    Plastic and Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
    J Plast Reconstr Aesthet Surg 61:1049-58. 2008
    ..We aimed to explore the influence of skin scars on patients' quality of life (QoL) and identify potential implications for clinical practice...
  44. ncbi Regeneration of nigrostriatal dopaminergic axons after transplantation of olfactory ensheathing cells and fibroblasts prevents fibrotic scar formation at the lesion site
    Xichuan Teng
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
    J Neurosci Res 86:3140-50. 2008
    ..The present results suggest that elimination of the inhibitory fibrotic scar is important for neural regeneration...
  45. ncbi The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea
    Y Chang
    Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan City, China
    J Int Med Res 37:727-36. 2009
    ..Analysis by real-time reverse transcription-polymerase chain reaction showed that the mRNA levels of the genes for CTGF, fibronectin and collagen Ialpha(1) in wound and corneal scar formation were reduced by SP600125 pre-treatment...
  46. ncbi Constant ocular infection with Chlamydia trachomatis predicts risk of scarring in children in Tanzania
    Meraf A Wolle
    Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ophthalmology 116:243-7. 2009
    ..We propose to determine the 5-year incidence of scarring in children with a history of constant severe trachoma, constant infection, or both compared with children who had a history of neither...
  47. ncbi Successful treatment of acneiform scarring with CO2 ablative fractional resurfacing
    Anne M Chapas
    Laser and Skin Surgery Center of New York, New York, NY 10016, USA
    Lasers Surg Med 40:381-6. 2008
    ..A novel ablative 30 W CO(2) laser device uses a technique called ablative fractional resurfacing (AFR), combines CO(2) ablation with a FP system...
  48. ncbi Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice
    Osamu Yamanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 13:1730-9. 2007
    ..To examine the effects of blocking p38 mitogen-activated protein kinase (MAPK) on post-injury conjunctival scarring in mice. Its effects on the behaviors of cultured subconjunctival fibroblasts were also investigated...
  49. ncbi Post acne scarring: a review
    Greg Goodman
    Skin and Cancer Foundation of Victoria, Carlton, Victoria, Australia
    J Cosmet Laser Ther 5:77-95. 2003
    ..Most often occurring extra-facially and in males, these distressing scars often require multiple treatments and modalities before adequate improvement is achieved...
  50. ncbi Solid hyaluronic acid film and the prevention of postoperative fibrous scar formation in experimental animal eyes
    Kimio Takeuchi
    Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Arch Ophthalmol 127:460-4. 2009
    ..To investigate the inhibitory effect of solid hyaluronic acid-carboxymethyl cellulose film (hyaluronic acid film) on the formation of postoperative wound adhesion on rabbit eyes...
  51. ncbi Cesarean scar ectopic pregnancies: etiology, diagnosis, and management
    Michael A Rotas
    Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York 11219, USA
    Obstet Gynecol 107:1373-81. 2006
    ..To clarify the appropriate way to diagnose and treat an ectopic pregnancy in the uterine scar of a prior cesarean delivery...
  52. ncbi Recovery from spinal cord injury: a new transection model in the C57Bl/6 mouse
    Alexander Seitz
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Neurosci Res 67:337-45. 2002
    ..Such studies suggest a new murine model for the study of spinal cord regeneration...
  53. ncbi The spectrum of laser skin resurfacing: nonablative, fractional, and ablative laser resurfacing
    Macrene R Alexiades-Armenakas
    Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA
    J Am Acad Dermatol 58:719-37; quiz 738-40. 2008
    ....
  54. doi Scar treatments: preclinical and clinical studies
    Richard G Reish
    Division of Plastic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Coll Surg 206:719-30. 2008
  55. ncbi BCG vaccination scar associated with better childhood survival in Guinea-Bissau
    Adam Roth
    Bandim Health Project, Apartado 861, Bissau, Guinea Bissau
    Int J Epidemiol 34:540-7. 2005
    ..No study has previously examined the influence of BCG vaccination on cause of death...
  56. pmc Promotion of incisional wound repair by human mesenchymal stem cell transplantation
    Alexander Stoff
    Division of Human Gene Therapy, Departments of Medicine, Obstetrics and Gynecology, Pathology, Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Exp Dermatol 18:362-9. 2009
    ..In conclusion, human mesenchymal stem cell therapy is a viable approach to significantly affect the course of normal cutaneous wound healing and significantly increase the tensile strength...
  57. ncbi Inhibition of vascular endothelial growth factor reduces scar formation after glaucoma filtration surgery
    Zhongqiu Li
    Laboratory of Ophthalmology, Catholic University Leuven, Leuven, Belgium
    Invest Ophthalmol Vis Sci 50:5217-25. 2009
    ....
  58. pmc Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia
    Pratima Karnik
    Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Invest Dermatol 129:1243-57. 2009
    ..We propose that PPARgamma-targeted therapy may represent a new strategy in the treatment of these disorders...
  59. ncbi Spontaneous regeneration of the corticospinal tract after transection in young rats: collagen type IV deposition and astrocytic scar in the lesion site are not the cause but the effect of failure of regeneration
    Tsutomu Iseda
    Department of Integrative Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Comp Neurol 464:343-55. 2003
    ..The major sign, and perhaps cause, of failure of axonal regeneration is likely the prolonged disappearance of astrocytes around the lesion site in the early postinjury period...
  60. pmc Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring
    Ryoichi Mori
    Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Exp Med 205:43-51. 2008
    ..Thus, OPN and PDGF are potential targets for therapeutic modulation of skin repair to improve healing rate and quality...
  61. ncbi Inhibition of glial scarring in the injured rat brain by a recombinant human monoclonal antibody to transforming growth factor-beta2
    A Logan
    Department of Medicine, University of Birmingham, UK
    Eur J Neurosci 11:2367-74. 1999
    ....
  62. pmc Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia
    Jacobus W A Burger
    Department of General Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Surg 240:578-83; discussion 583-5. 2004
    ..The objective of this study was to determine the best treatment of incisional hernia, taking into account recurrence, complications, discomfort, cosmetic result, and patient satisfaction...
  63. ncbi Resident nestin+ neural-like cells and fibers are detected in normal and damaged rat myocardium
    Viviane El-Helou
    Department of Physiology, University of Montreal, Montreal Heart Institute, Montreal, Quebec, Canada
    Hypertension 46:1219-25. 2005
    ..Cardiac tissue-derived neural stem cell migration to the infarct region and concomitant nestin+ fiberlike innervation represent obligatory events of reparative fibrosis in the damaged rat myocardium...
  64. pmc Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring
    Julie T Daniels
    Epithelial Repair and Regeneration Group, Wound Healing Research Unit, Divisions of Pathology and Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, United Kingdom
    Am J Pathol 163:2043-52. 2003
    ..Inhibition of CTGF activity or gene transcription could be a suitable target for anti-scarring therapies...
  65. ncbi A novel TGF-beta antagonist speeds reepithelialization and reduces scarring of partial thickness porcine burns
    Adam J Singer
    Department of Emergency Medicine and the Division of Laboratory Animal Research, Stony Brook University, New York, USA
    J Burn Care Res 30:329-34. 2009
    ..002) at 28 days. Treatment of partial thickness porcine burns with the TGF-beta antagonist speeds reepithelialization and reduces scar formation and wound contraction in partial thickness porcine burns...
  66. ncbi Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFbeta1 and beta2
    L D Moon
    Physiological Department, University of Cambridge, Downing Site, Cambridge, CB2 3EG, UK
    Eur J Neurosci 14:1667-77. 2001
    ....
  67. ncbi The hypothesis of 'biophysical matrix contraction': wound contraction revisited
    Ramin Mostofizadeh Farahani
    School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
    Int Wound J 5:477-82. 2008
    ..The aforementioned contractile activity proceeds into the remodelling phase of wound healing as the level of TGF-beta is reduced and myofibroblasts undergo apoptosis...
  68. pmc Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease
    Yunliang Chen
    Centre for Rheumatology, University College London, Royal Free Campus, UK
    Am J Pathol 167:1699-711. 2005
    ..We conclude that antagonizing MEK/ERK, TGFbeta1/ALK5, or syndecan 4 may alleviate scarring in chronic fibrotic disease...
  69. ncbi Keratocyte and fibroblast phenotypes in the repairing cornea
    M E Fini
    New England Medical Center, Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02111, USA
    Prog Retin Eye Res 18:529-51. 1999
    ....
  70. ncbi The histopathology of primary cicatricial alopecia
    Leonard C Sperling
    Department of Dermatology, Uniformed Services University, Bethesda, MD 20814, USA
    Semin Cutan Med Surg 25:41-50. 2006
    ..Herein, we present an overview of the histologic assessment of cicatricial alopecia, including an algorithmic approach to the evaluation of biopsy specimens from patients with scarring alopecia...
  71. ncbi The CNS lesion scar: new vistas on an old regeneration barrier
    C C Stichel
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Cell Tissue Res 294:1-9. 1998
    ..This review briefly summarizes the current knowledge on (a) the structural and functional features of the lesion scar and (b) the development of therapeutic interventions to override this regeneration barrier...
  72. ncbi Roles of Eph receptors and ephrins in the normal and damaged adult CNS
    Yona Goldshmit
    Centre for Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia
    Brain Res Rev 52:327-45. 2006
    ..Therefore, Eph/ephrin signaling may inhibit regeneration by more than one mechanism and modulation of Eph receptor expression or signaling could prove pivotal in determining the outcome of injury in the adult CNS...
  73. ncbi Prolonged antiscarring effects of ilomastat and MMC after experimental glaucoma filtration surgery
    Tina T L Wong
    Ocular Repair and Regeneration Biology Unit, Institute of Ophthalmology, London, UK
    Invest Ophthalmol Vis Sci 46:2018-22. 2005
    ..To determine the long-term antiscarring effect of ilomastat treatment after experimental glaucoma filtration surgery (GFS)...
  74. ncbi Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds
    Kunoor Jain
    Division of Pediatric Surgery, Department of Surgery, Virginia Commonwealth University Health System, Richmond, Virginia 23298, USA
    J Surg Res 148:45-8. 2008
    ..We theorize that Hoxd3 and Hoxd8 will be differentially expressed in mid- and late-gestational wounds compared with normal skin...
  75. ncbi A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord
    Barbara Grimpe
    Case Western Reserve University, School of Medicine, Department of Neurosciences, Cleveland, Ohio 44106, USA
    J Neurosci 24:1393-7. 2004
    ..Our experiments demonstrate the critical role of PGs, and particularly those in the penumbra, in causing regeneration failure in the adult spinal cord...
  76. ncbi Structural fat grafting: more than a permanent filler
    Sydney R Coleman
    New York University School of Medicine, New York 10013, USA
    Plast Reconstr Surg 118:108S-120S. 2006
    ..Of particular interest is the research that has pointed to the use of stem cells to repair and even to become bone, cartilage, muscle, blood vessels, nerves, and skin. Further studies are essential to understand grafted fat tissue...
  77. ncbi Head-to-head comparison between contrast-enhanced magnetic resonance imaging and dobutamine magnetic resonance imaging in men with ischemic cardiomyopathy
    Theodorus A M Kaandorp
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Cardiol 93:1461-4. 2004
    ..In these segments, low-dose dobutamine MRI may be needed to optimally differentiate myocardium with large and small likelihoods of functional recovery after revascularization...
  78. ncbi Wound healing in oral mucosa results in reduced scar formation as compared with skin: evidence from the red Duroc pig model and humans
    Joyce W Wong
    Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC, Canada
    Wound Repair Regen 17:717-29. 2009
    ..Thus, the reduced scar formation in the pig oral mucosa provides a model to study the biological processes that regulate scarless wound healing to find novel approaches to prevent scar formation in skin...
  79. ncbi Modulation of wound healing during and after glaucoma surgery
    Stelios Georgoulas
    Ocular Repair and Regeneration Biology Research Unit, National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London EC1V 9EL, UK
    Prog Brain Res 173:237-54. 2008
    ..Many promising new agents are being evaluated clinically and in vitro. In this chapter, we will discuss our current understanding of the wound healing process after glaucoma surgery and promising new treatment modalities...
  80. ncbi Olfactory ensheathing glia: their contribution to primary olfactory nervous system regeneration and their regenerative potential following transplantation into the injured spinal cord
    Elske H P Franssen
    Netherlands Insitute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Brain Res Rev 56:236-58. 2007
    ..We believe that genome-wide gene expression studies of OEG in their native environment, in culture and after transplantation will ultimately reveal unique combinations of molecules involved in the regeneration-promoting potential of OEG...
  81. ncbi The management of postacne scarring
    Greg J Goodman
    Skin and Cancer Foundation of Victoria and Monash University Department of Community Medicine, Victoria, Australia
    Dermatol Surg 33:1175-88. 2007
    ..Within the past decade, however, a greater understanding of the pathogenesis of acne scarring has led to the development of techniques that offer more favorable risk-benefit profiles...
  82. pmc Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS
    Rhonda R Voskuhl
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 29:11511-22. 2009
    ..The findings suggest that loss or disruption of astrocyte functions may underlie or exacerbate the inflammation and pathologies associated with autoimmune diseases of the CNS, including multiple sclerosis...
  83. ncbi Primary vesicoureteral reflux mediated renal scarring after urinary tract infection in Thai children
    Prayong Vachvanichsanong
    Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand
    Nephrology (Carlton) 13:38-42. 2008
    ..To evaluate the association between primary vesicoureteral reflux (VUR) and renal scarring in children using 99 m Technetium-labelled dimercaptosuccinic acid (DMSA)...
  84. pmc Gene delivery of a mutant TGFβ3 reduces markers of scar tissue formation after cutaneous wounding
    Simon N Waddington
    Institute for Women s Health, University College London, London, UK
    Mol Ther 18:2104-11. 2010
    ....
  85. ncbi Management of primary cicatricial alopecias: options for treatment
    M J Harries
    The Dermatology Centre, The University of Manchester, Hope Hospital, Manchester M6 8HD, UK
    Br J Dermatol 159:1-22. 2008
    ..Wherever only insufficient evidence-based advice on PCA management can be given at present, this is indicated so as to highlight important gaps in our clinical knowledge that call for concerted efforts to close these in the near future...
  86. ncbi The effect of 10-hydroxycamptothecine in preventing fibroblast proliferation and epidural scar adhesion after laminectomy in rats
    Yu Sun
    Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, Jiangsu Province, China
    Eur J Pharmacol 593:44-8. 2008
    ..In conclusion, topical application of 0.1 mg/ml HCPT could effectively prevent fibroblast proliferation and reduce epidural adhesion after laminectomy in rats...
  87. ncbi Basement membrane and collagen deposition after laser subepithelial keratomileusis and photorefractive keratectomy in the leghorn chick eye
    Joel A D Javier
    Massachusetts Eye and Ear Infirmary and the Schepens Eye Research Institute, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Arch Ophthalmol 124:703-9. 2006
    ..To evaluate corneal scar formation and new collagen deposition after laser subepithelial keratomileusis (LASEK) compared with photorefractive keratectomy (PRK) in the leghorn chick corneal model...
  88. ncbi Histometric and histochemical analysis of the effect of trichloroacetic acid concentration in the chemical reconstruction of skin scars method
    Sung Bin Cho
    Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea
    Dermatol Surg 32:1231-6; discussion 1236. 2006
    ..Atrophic scars can be induced by various causes, including severely inflamed acne, chicken pox, and trauma. Many treatment modalities are used for reconstructing and improving the appearance of scars with various treatment results...
  89. pmc In vivo confocal microscopy in scarring trachoma
    Victor H Hu
    International Centre for Eye Health, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Ophthalmology 118:2138-46. 2011
    ..To characterize the tissue and cellular changes found in trachomatous scarring (TS) and inflammation using in vivo confocal microscopy (IVCM)...
  90. ncbi Acne scar correction using calcium hydroxylapatite in a carrier-based gel
    David J Goldberg
    Skin Laser and Surgery Specialists of New York New Jersey, New York, NY 10022, USA
    J Cosmet Laser Ther 8:134-6. 2006
    ..This study sought to determine the efficacy and safety profile of calcium hydroxylapatite filler in the treatment of acne scars...
  91. ncbi Regeneration of nigrostriatal dopaminergic axons by degradation of chondroitin sulfate is accompanied by elimination of the fibrotic scar and glia limitans in the lesion site
    Hong Peng Li
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Neurosci Res 85:536-47. 2007
    ....
  92. ncbi Nonablative fractional laser resurfacing
    Vic A Narurkar
    Department of Dermatology, California Pacific Medical Center, San Francisco, CA, USA
    Dermatol Clin 27:473-8, vi. 2009
    ..Future approaches include synergistic treatments with radiofrequency devices and the development of novel wavelengths to enhance the efficacy of NFR while preserving safety...
  93. ncbi A survey of trachoma: the histopathology and the mechanism of progressive cicatrization of eyelid tissues
    M Guzey
    Department of Ophthalmology, Harran University School of Medicine, Sanliurfa, Turkey
    Ophthalmologica 214:277-84. 2000
    ..The contraction of the subepithelial fibrous tissue formed by collagen fibres and anterior surface drying are the main factors contributing to the chronic cicatrization and entropion formation...
  94. ncbi Interpretation and precision of the Observer Scar Assessment Scale improved by a revised scoring
    Jerome A Lindeboom
    Department of Oral and Maxillofacial Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Epidemiol 61:1289-95. 2008
    ..To apply Rasch measurement to develop a rule for clinical interpretation of the Observer Scar Assessment Scale (OSAS) to help surgeons judge reported sum scores clinically...
  95. pmc Injectable poly-L: -lactic acid: a novel sculpting agent for the treatment of dermal fat atrophy after severe acne
    Richard Sadove
    Department of Plastic Surgery, University of Florida College of Medicine, 9227 SW 43rd Lane, Gainesville, FL 32608, USA
    Aesthetic Plast Surg 33:113-6. 2009
    ....
  96. ncbi Fraxel laser indications and long-term follow-up
    Elizabeth L Tanzi
    Aesthet Surg J 28:675-8; discussion 679-80. 2008
    ..However, the improvement seen after a series of Fraxel treatments for perioral laxity and rhytides often falls short of the impressive results that can be achieved with ablative laser skin resurfacing...
  97. ncbi Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats
    Rafet Ozay
    Department of Neurosurgery, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey
    Surg Neurol 68:615-22; discussion 622. 2007
    ..Citicoline has been shown to have beneficial effects in a variety of CNS injury models. The aim of this study was to test the effects of citicoline on nerve regeneration and scarring in a rat model of peripheral nerve surgery...
  98. ncbi Quantitative and qualitative dermal change with microfat grafting of facial scars
    Maya G Sardesai
    Department of Otolaryngology, St Joseph s Health Care, London, ON, Canada
    Otolaryngol Head Neck Surg 137:868-72. 2007
    ..To evaluate changes in dermal characteristics with subdermal fat grafting of cutaneous scars...
  99. pmc Trabeculectomy and antimetabolites
    S Fraser
    Br J Ophthalmol 88:855-6. 2004
  100. ncbi Suppression of fibrotic scar formation promotes axonal regeneration without disturbing blood-brain barrier repair and withdrawal of leukocytes after traumatic brain injury
    Nozomu Yoshioka
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    J Comp Neurol 518:3867-81. 2010
    ..These results indicate that suppression of fibrotic scar formation does not disturb the healing process in damaged CNS, and suggest that this strategy is a reliable tool to promote axonal regeneration after traumatic injury in the CNS...
  101. ncbi Psychopathology and psychological problems in patients with burn scars: epidemiology and management
    Nancy E E Van Loey
    Department of Research, Dutch Burns Foundation, Beverwijk, The Netherlands
    Am J Clin Dermatol 4:245-72. 2003
    ..Finally, objective characteristics of disfigurement appear to play a minor role, although other factors, such as proneness to shame, body image problems, and lack of self-esteem, may be of significance...

Research Grants60

  1. MR Guided Transendocardial Angiogenic Agents
    Maythem Saeed; Fiscal Year: 2007
    ..abstract_text> ..
  2. Mechanisms of myometrial healing and regeneration
    Catalin Buhimschi; Fiscal Year: 2006
    ....
  3. Visual outcomes & quality of life in CMV retinitis
    Jennifer Thorne; Fiscal Year: 2006
    ..abstract_text> ..
  4. CLINICAL RESEARCH CURRICULUM
    Karla Zadnik; Fiscal Year: 2004
    ..abstract_text> ..
  5. Vision Research--Biostatistics and Epidemiology Module
    Karla Zadnik; Fiscal Year: 2007
    ..abstract_text> ..
  6. OPTOMETRY COORDINATING CENTER
    Karla Zadnik; Fiscal Year: 2002
    ....
  7. COLLABORATIVE LONGITUDINAL EVALUATION KERATOCONUS STUDY
    Karla Zadnik; Fiscal Year: 2004
    ..Louis, Missouri, and the CLEK Photography Reading Center at The Ohio State University College of Optometry, Columbus, Ohio. ..
  8. Microarray Analysis of Wounds
    AMY COLWELL; Fiscal Year: 2004
    ..We hypothesize these genes can be used to modulate the biology of adult wound healing. This first step will form our basis for developing treatment to induce scarless healing. ..
  9. Cicatricial alopecia Colloquium
    Paradi Mirmirani; Fiscal Year: 2005
    ....
  10. Molecular Analysis of Scarless Fetal Wound Healing
    Sandeep Kathju; Fiscal Year: 2007
    ..With these complementary approaches we hope to thereby arrive at a broad understanding of the gene patterns controlling both fetal and adult wound healing, and identify gene products/pathways critical to both. ..
  11. Nanoparticle Targeting to Control Angiogenesis
    JEFFREY DAVIDSON; Fiscal Year: 2006
    ..The objective is to design drug delivery systems that will specifically target pathological angiogenesis with minimal effects on the normal vasculature. ..
  12. ANTI-SCARRING AND ANTI-INFLAMMATORY EFFECTS OF AMNIOTIC MEMBRANE EXTRACTS
    Scheffer Tseng; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  13. Role of TGF-b In Excessive Scarring: A Cutaneous Model
    Thomas Mustoe; Fiscal Year: 2005
    ..abstract_text> ..
  14. Older Age Health and Longevity: A Long-Term View
    DORA COSTA; Fiscal Year: 2006
    ..abstract_text> ..
  15. Hypertrophic Scarring After Partial-Thickness Wounds
    LOREN ENGRAV; Fiscal Year: 2006
    ..We will laser capture microdissect cones from shallow and deep partial-thickness Duroc wounds, extract and amplify the mRNA, and perform porcine DNA array analysis to determine which genes are differentially expressed. ..
  16. A Self-Sustaining Perinatal Care System for Tibet
    Michael Varner; Fiscal Year: 2006
    ..abstract_text> ..
  17. GTPase Activating Proteins in Aging and Osteoarthritis
    Lisa Fortier; Fiscal Year: 2007
    ..We anticipate that these findings will facilitate identification of target molecules for development of therapeutics modalities for OA. [unreadable] [unreadable] [unreadable]..
  18. ANGIOTENSIN ANALOGS TO TREAT WOUND HEALING
    Kathleen Rodgers; Fiscal Year: 2005
    ..In this phase II SBIR, these compounds will undergo extensive preclinical testing to determine whether they should be further developed as a second generation of wound healing drugs. ..
  19. Enhanced Primary Repair of Ligament Injuries
    Martha Murray; Fiscal Year: 2008
    ..In the third aim, the optimized scaffolds will be tested in an in vivo canine ACL non-union model. Information gained in each of these aims will serve to improve our understanding of mechanisms of ligament healing. ..
  20. Optical guidance of surgical excision of skin cancer
    Ken Lee; Fiscal Year: 2008
    ..A library of images of normal and cancer will be accrued and an image analysis algorithm developed to assist the visualization of the cancer margin. ..
  21. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
    ....
  22. Axon Plasticity and Recovery of Function after Traumatic Brain Injury
    Neil Harris; Fiscal Year: 2010
    ....
  23. Muller glia and neuronal regeneration in the retina
    Andy Fischer; Fiscal Year: 2009
    ..This information could be applied to not only stimulate neural regeneration to treat sight-threatening diseases of the retina, but also to control gliosis that may be detrimental to the pathogenesis of retinal disorders. ..
  24. LEF/TCF Function in Adult Stem Cell Fate and Tumorigenesis
    Stephen R Lyle; Fiscal Year: 2010
    ....
  25. GAP JUNCTIONAL COMMUNICATIONS IN WOUND HEALING
    H Ehrlich; Fiscal Year: 2009
    ..abstract_text> ..
  26. Genetic factors in outcome from traumatic brain injury
    Ramon Diaz Arrastia; Fiscal Year: 2008
    ..These studies may provide genetic evidence for a role of specific genes in tissue response after TBI, and may identify novel targets for therapeutic intervention. ..
  27. EX VIVO EXPANSION OF RPE CELLS FOR TRANSPLANTATION
    Scheffer Tseng; Fiscal Year: 2005
    ..Success in accomplishing these goals will allow us to engineer this new tissue-based "Biologies" to restore sights in patients suffering ARMD or other retinal diseases in which RPE is dysfunctional. ..
  28. 9.4 Tesla MR Scanner for Murine Imaging
    STUART BERR; Fiscal Year: 2005
    ..7T. The enhanced capabilities of the new system will be brought to fruition through an existing comprehensive technical, scientific, and administrative plan. ..
  29. Prediciting Severe Neonatal Hyperbilirubinemia
    Ron Keren; Fiscal Year: 2007
    ....
  30. Multi-Modality Patient-Specific Evaluation of Ischemia
    Randolph Setser; Fiscal Year: 2006
    ..If successful, this proposal could enhance visualization of the effects of coronary artery disease in individual patients, thus enabling optimized revascularization planning tailored to the individual's anatomy. ..
  31. IBA Cyclone 18/9 Cyclotron
    STUART BERR; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  32. TRANSPLANTATION OF EXPANDED LIMBAL EPITHELIAL STEM CELLS
    Scheffer Tseng; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  34. DEVELOPMENT OF SUTURELESS AMNIOTIC MEMBRANE GRAFT
    Scheffer Tseng; Fiscal Year: 2007
    ..Taken together, we may further promote our business development by expanding the market potential using Prokera(tm) for suture-less AMT. [unreadable] [unreadable]..
  35. 2008 Proteoglycans Gordon Research Conference
    Thomas Wight; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  36. IMPACT OF AGING, ISCHEMIA AND CYTOKINES ON WOUND HEALING
    Thomas Mustoe; Fiscal Year: 2002
    ....
  37. Regulation of Cell Function by Matricellular Hevin
    Thomas Wight; Fiscal Year: 2008
    ....
  38. KERATOCYTE CRYSTALLIN PROTEINS AND CORNEAL TRANSPARENCY
    JAMES JESTER; Fiscal Year: 2003
    ....
  39. STRUCTURAL BASES FOR OPTICAL PROPERTIES OF CORNEAS
    RUSSELL MCCALLY; Fiscal Year: 2004
    ..For the rabbit study, resolution and F.A.C.T. charts will be imaged through freshly excised corneas and the potential degradation in visual performance will be correlated with scatterometer measurements. ..
  40. Cellular and Molecular Biology of Keloid Pathogenesis
    Michael Longaker; Fiscal Year: 2005
    ..In this way, we hope to create an in vivo analog to our in vitro coculture model. The central hypothesis to be tested in this proposal is that KHKs interact with KHFs in promoting keloid pathogenesis..
  41. Selectins and Fetal wound Healing
    Oluyinka Olutoye; Fiscal Year: 2007
    ..These may then provide opportunities to assist with the inflammatory responses in these children when they are most vulnerable. ..
  42. Prevention of Hip Dysplasia with Thermal Energy
    MANDI LOPEZ; Fiscal Year: 2005
    ..The University of Wisconsin provides an exceptional environment for interaction with experts in a variety of fields, and it is well known for its exceptional research programs, especially in the medical sciences. ..
  43. DISTRACTION OSTEOGENESIS--ENDOGENOUS TISSUE ENGINEERING
    Michael Longaker; Fiscal Year: 2002
    ..The long term objective of this work is to gain insight into the mechanisms that regulate osteogenesis in general and, mandibular DO in particular, in order to advance the discipline of osseous tissue engineering. ..
  44. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
  45. A Novel Mechanism for Intra-articular Nonunion
    Martha M Murray; Fiscal Year: 2010
    ....
  46. Novel Antagonists for Ameliorating Pulmonary Fibrosis
    JUNG HUANG; Fiscal Year: 2007
    ..The novel antagonists developed in this project should be ideal drug candidates for treating pulmonary fibrosis in humans. [unreadable] [unreadable] [unreadable]..
  47. REGULATION OF FUNCTIONALLY REACTIVE GLIOSIS BY TGF-BETA
    Robert McKeon; Fiscal Year: 2002
    ....
  48. Interdisciplinary Regenerative Medicine Training Program(RMI)
    Michael Longaker; Fiscal Year: 2008
    ..abstract_text> ..
  49. Reactive scar-forming astrocytes after spinal cord injur
    MICHAEL SOFRONIEW; Fiscal Year: 2003
    ....
  50. CELLULAR AND MOLECULAR MECHANISMS OF CALVARIAL HEALING
    Michael Longaker; Fiscal Year: 2006
    ..Finally, we will determine the origin of the osteoblasts that contribute to calvarial re-ossification. ..
  51. Interdisciplinary Regenerative Medicine Training Program(RMI)
    Michael Longaker; Fiscal Year: 2008
    ..abstract_text> ..
  52. Renal Disease Progression in African Americans
    JEFFREY SCHELLING; Fiscal Year: 2005
    ..Cases and controls will be compared using both univariate and multivariate approaches. Environmental correlates will be included in the models. ..
  53. MOLECULAR MECHANISMS OF CRANIAL SUTURE FUSION
    Michael Longaker; Fiscal Year: 2007
    ..Finally, pathologically fusing sutures will be rescued with perinatal gene therapy using a Noggin adenovirus. ..
  54. Biology of GFAP-expressing neural progenitors
    MICHAEL SOFRONIEW; Fiscal Year: 2008
    ..abstract_text> ..
  55. Planning the Stanford Center for Translational Medicine
    Michael Longaker; Fiscal Year: 2006
    ..This planning phase will form the strong foundation of a successful SoM effort resulting in greatly expanded efforts in the emerging field of Translational Medicine. [unreadable] [unreadable] [unreadable]..
  56. International Conference on Advances in Laryngeal Biophysiology
    Susan Thibeault; Fiscal Year: 2008
    ..The multifactorial nature of voice disorders necessitates study for a comprehensive understanding of the disease mechanisms for optimal treatment success. [unreadable] [unreadable] [unreadable] [unreadable]..
  57. Safety & effectiveness of HA hydrogels in immortalized vocal fold fibroblast cell
    Susan Thibeault; Fiscal Year: 2007
    ..Efforts from this R21 will provide imminent directions for an R01 focusing on human clinical trials for treatment of ECM disorders. [unreadable] [unreadable] [unreadable]..
  58. Subglottic Stenosis and Laryngotracheal Mucosal Healing
    PATRICIA HEBDA; Fiscal Year: 2009
    ....
  59. Fine Needle Aspiration of Benign Vocal Fold Lesions
    Susan Thibeault; Fiscal Year: 2004
    ..abstract_text> ..
  60. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
    ..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..