acne vulgaris

Summary

Summary: A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.

Top Publications

  1. ncbi The impact of acne vulgaris on the quality of life and psychologic status in patients from upper Egypt
    Kamal Abdel-Hafez
    Department of Dermatology, Assiut University, Assiut, Egypt
    Int J Dermatol 48:280-5. 2009
  2. ncbi The complete genome sequence of Propionibacterium acnes, a commensal of human skin
    Holger Bruggemann
    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany
    Science 305:671-3. 2004
  3. ncbi A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, UK
    Microbiology 157:1990-2003. 2011
  4. ncbi Acne vulgaris
    Hywel C Williams
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Lancet 379:361-72. 2012
  5. ncbi Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses
    Jenny Kim
    Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 169:1535-41. 2002
  6. ncbi An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study
    A C Jahns
    Department of Medical Biosciences Pathology, Umea University, Umeå S 90185, Sweden
    Br J Dermatol 167:50-8. 2012
  7. ncbi Inflammatory events are involved in acne lesion initiation
    Anthony H T Jeremy
    University of Leeds, and Leeds General Infirmary, Leeds, UK
    J Invest Dermatol 121:20-7. 2003
  8. ncbi The role of Propionibacterium acnes in acne pathogenesis: facts and controversies
    Clio Dessinioti
    Department of Dermatology, Andreas Sygros Hospital, University of Athens, 5, I Dragoumi Street, 16121, Athens, Greece
    Clin Dermatol 28:2-7. 2010
  9. ncbi Quality of life and acne in Scottish adolescent schoolchildren: use of the Children's Dermatology Life Quality Index (CDLQI) and the Cardiff Acne Disability Index (CADI)
    N Walker
    Department of Dermatology, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    J Eur Acad Dermatol Venereol 20:45-50. 2006
  10. ncbi Management of acne: a report from a Global Alliance to Improve Outcomes in Acne
    Harald Gollnick
    American Academy of Dermatology, Inc
    J Am Acad Dermatol 49:S1-37. 2003

Research Grants

Detail Information

Publications325 found, 100 shown here

  1. ncbi The impact of acne vulgaris on the quality of life and psychologic status in patients from upper Egypt
    Kamal Abdel-Hafez
    Department of Dermatology, Assiut University, Assiut, Egypt
    Int J Dermatol 48:280-5. 2009
    b>Acne vulgaris is a common skin disease. Although neither life threatening nor physically debilitating, acne can severely affect social and psychologic functioning...
  2. ncbi The complete genome sequence of Propionibacterium acnes, a commensal of human skin
    Holger Bruggemann
    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg August University Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany
    Science 305:671-3. 2004
    ..it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation...
  3. ncbi A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, 97 Lisburn Road, Belfast BT9 7BL, UK
    Microbiology 157:1990-2003. 2011
    ..The MLST scheme and database described in this study should provide a valuable platform for future epidemiological and evolutionary studies of P. acnes...
  4. ncbi Acne vulgaris
    Hywel C Williams
    Centre of Evidence Based Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK
    Lancet 379:361-72. 2012
    ..New research is needed into the therapeutic comparative effectiveness and safety of the many products available, and to better understand the natural history, subtypes, and triggers of acne...
  5. ncbi Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses
    Jenny Kim
    Division of Dermatology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 169:1535-41. 2002
    ..These data suggest that P. acnes triggers inflammatory cytokine responses in acne by activation of TLR2. As such, TLR2 may provide a novel target for treatment of this common skin disease...
  6. ncbi An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study
    A C Jahns
    Department of Medical Biosciences Pathology, Umea University, Umeå S 90185, Sweden
    Br J Dermatol 167:50-8. 2012
    b>Acne vulgaris is a disorder of the sebaceous follicles. Propionibacterium acnes can be involved in inflammatory acne.
  7. ncbi Inflammatory events are involved in acne lesion initiation
    Anthony H T Jeremy
    University of Leeds, and Leeds General Infirmary, Leeds, UK
    J Invest Dermatol 121:20-7. 2003
    ..These results provide novel evidence for vascular endothelial cell activation and involvement of inflammatory responses in the very earliest stages of acne lesion development...
  8. ncbi The role of Propionibacterium acnes in acne pathogenesis: facts and controversies
    Clio Dessinioti
    Department of Dermatology, Andreas Sygros Hospital, University of Athens, 5, I Dragoumi Street, 16121, Athens, Greece
    Clin Dermatol 28:2-7. 2010
    ..Emerging data that inflammatory events occur in the very earliest stages of acne development have reopened the debate about the potential involvement of this microorganism in comedogenesis and acne initiation...
  9. ncbi Quality of life and acne in Scottish adolescent schoolchildren: use of the Children's Dermatology Life Quality Index (CDLQI) and the Cardiff Acne Disability Index (CADI)
    N Walker
    Department of Dermatology, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    J Eur Acad Dermatol Venereol 20:45-50. 2006
    b>Acne vulgaris is known to adversely affect all aspects of quality of life. However, although acne is thought to occur in the majority of adolescents, there are few data currently available on the impact of acne in this age group.
  10. ncbi Management of acne: a report from a Global Alliance to Improve Outcomes in Acne
    Harald Gollnick
    American Academy of Dermatology, Inc
    J Am Acad Dermatol 49:S1-37. 2003
  11. ncbi New developments in our understanding of acne pathogenesis and treatment
    Ichiro Kurokawa
    Department of Dermatology, Mie Universtity Graduate School of Medicine, Tsu, Mie, Japan
    Exp Dermatol 18:821-32. 2009
    ..We provide a summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years (2005-2008)...
  12. ncbi Review of the innate immune response in acne vulgaris: activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses
    Jenny Kim
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, 90095, USA
    Dermatology 211:193-8. 2005
    b>Acne vulgaris is a common disorder that affects 40-50 million people in the USA alone. The pathogenesis of acne is multifactorial, including hormonal, microbiological and immunological mechanisms...
  13. ncbi Induction of toll-like receptors by Propionibacterium acnes
    S Jugeau
    INSERM U601, CHU, Pl A Ricordeau, 44095 Nantes, France
    Br J Dermatol 153:1105-13. 2005
    ..Recent studies have found that keratinocytes express toll-like receptors (TLRs) implicated in immediate immunity. No studies have, to date, been carried out on the action of P. acnes upon TLR activation in keratinocytes...
  14. pmc Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne
    Hans B Lomholt
    Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    PLoS ONE 5:e12277. 2010
    ..The results of the study indicate that particular clones of P. acnes play an etiologic role in acne while others are associated with health...
  15. ncbi The prevalence of acne in adults 20 years and older
    Christin N Collier
    School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0009, USA
    J Am Acad Dermatol 58:56-9. 2008
    ..However, a significant number of patients either continue to experience acne or develop new-onset acne after the teenaged years...
  16. ncbi Anakinra for flares of pyogenic arthritis in PAPA syndrome
    M P Dierselhuis
    Rheumatology (Oxford) 44:406-8. 2005
  17. ncbi In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris
    Naoto Yamaguchi
    Betal, LLC, 5185 MacArthur Blvd, NW, Suite 300, Washington, DC 20016, USA
    Phytomedicine 16:369-76. 2009
    ..extracts were tested for evaluation of biological activities affecting acne vulgaris. Five strains, Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus, Kocuria rhizophila ..
  18. pmc Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne)
    Andrew P Demidowich
    National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    Arthritis Rheum 64:2022-7. 2012
    ..To describe the genotypes, phenotypes, immunophenotypes, and treatments of PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne), a rare autoinflammatory disease, in 5 patients...
  19. pmc Acne is not associated with yet-uncultured bacteria
    M Bek-Thomsen
    Institute of Medical Microbiology and Immunology, The Bartholin Building, Wilhelm Meyer s Allé 1240, Aarhus University, Aarhus C DK 8000, Denmark
    J Clin Microbiol 46:3355-60. 2008
    ..The findings of the study exclude the possibility that acne is associated with yet-uncultured bacteria and shows that healthy skin follicles constitute a remarkably exclusive habitat allowing colonization only by P. acnes...
  20. pmc Proteomic identification of secreted proteins of Propionibacterium acnes
    Carsten Holland
    Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany
    BMC Microbiol 10:230. 2010
    ..exhibits many traits of an opportunistic pathogen, playing roles in a variety of inflammatory diseases such as acne vulgaris. To date, the underlying disease-causing mechanisms remain ill-defined and knowledge of P...
  21. ncbi A microbial aetiology of acne: what is the evidence?
    B Shaheen
    Department of Dermatology, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
    Br J Dermatol 165:474-85. 2011
    ..suggests that micro-organisms, particularly Propionibacterium acnes, are important in the pathogenesis of acne vulgaris. However, it is still unclear whether P...
  22. ncbi Novel vesicular and particulate drug delivery systems for topical treatment of acne
    Gisele A Castro
    Federal University of Minas Gerais, Department of Pharmaceutics, 31270 901, Belo Horizonte, Minas Gerais, Brazil
    Expert Opin Drug Deliv 5:665-79. 2008
    ..Novel vesicular and particulate drug delivery systems have been proposed to reduce the side effects of drugs commonly used in the topical treatment of acne...
  23. ncbi Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study
    Jon A Halvorsen
    Faculty of Medicine, Department of Dermatology, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway
    J Invest Dermatol 131:363-70. 2011
    ..Adverse events including suicidal ideation and depression that have been associated with therapies for acne may reflect the burden of substantial acne rather than the effects of medication...
  24. ncbi Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults
    Anna Di Landro
    Centro Studi Gruppo Italiano Studi Epidemiologici in Dermatologia, Fondazione per la Ricerca Ospedale Maggiore, Bergamo, Italy
    J Am Acad Dermatol 67:1129-35. 2012
    ..Genetic and environmental components may contribute to acne causation...
  25. ncbi Antioxidant activity, lipid peroxidation and skin diseases. What's new
    S Briganti
    Cutaneous Physiopathology Laboratory, San Gallicano Dermatological Institute, 25 A Via S Gallicano, 00153 Rome, Italy
    J Eur Acad Dermatol Venereol 17:663-9. 2003
    ..Based on these findings, the review summarises the possible correlations between antioxidant imbalance, lipid oxidative breakage and skin diseases, from both a pathological and therapeutic points of view...
  26. pmc Characterization and genome sequencing of two Propionibacterium acnes phages displaying pseudolysogeny
    Rolf Lood
    Department of Clinical Sciences, Division of Infection Medicine, Lund University, Sweden
    BMC Genomics 12:198. 2011
    ..is a Gram positive rod inhabiting the human skin that also infects orthopaedic implants and is associated with acne vulgaris. Previously, one lytic bacteriophage, PA6, from P. acnes has been sequenced and partially characterized...
  27. ncbi Variable expression of immunoreactive surface proteins of Propionibacterium acnes
    Michael J Lodes
    Corixa Corporation, Infectious Disease Research Institute, Seattle, WA 98101, USA
    Microbiology 152:3667-81. 2006
    ..In contrast, serum from acne-negative donors shows an IgG2 and IgG3 antibody subclass response to the carboxy-terminal region. These data have implications for the potential role of P. acnes in inflammatory acne and other diseases...
  28. ncbi What is the pathogenesis of acne?
    C C Zouboulis
    Exp Dermatol 14:143-52. 2005
    For a long time, the mantra of acne pathogenesis debates has been that acne vulgaris lesions develop when (supposedly largely androgen-mediated) increased sebum production, ductal hypercornification, and propionibacteria come together ..
  29. ncbi The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides
    Robyn N Smith
    School of Applied Sciences, RMIT University, GPO Box 2476V, Melbourne, Victoria 3001, Australia
    J Dermatol Sci 50:41-52. 2008
    ..Dietary factors have long been implicated in acne pathogenesis. It has recently been hypothesized that low glycemic load diets may influence sebum production based on the beneficial endocrine effects of these diets...
  30. ncbi The effect of a high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial
    Robyn N Smith
    School of Applied Sciences, RMIT University, Melbourne, Victoria, Australia
    J Am Acad Dermatol 57:247-56. 2007
    No previous study has sought to examine the influence of dietary composition on acne vulgaris.
  31. ncbi The influence of dietary patterns on acne vulgaris in Koreans
    Jae Yoon Jung
    Department of Dermatology, Seoul National University College of Medicine, Chongno Gu, Seoul 110 744, Korea
    Eur J Dermatol 20:768-72. 2010
    ..This study also showed that a high glycemic load diet, dairy food intake, high fat diet, and iodine in Korean foods appear to play a role in acne exacerbation. In addition, irregular dietary patterns were found to aggravate acne...
  32. ncbi Biofilm formation by Propionibacterium acnes is associated with increased resistance to antimicrobial agents and increased production of putative virulence factors
    Tom Coenye
    Laboratorium voor Farmaceutische Microbiologie, Universiteit Gent, Harelbekestraat 72, B 9000 Gent, Belgium
    Res Microbiol 158:386-92. 2007
    Propionibacterium acnes plays an important role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles. Recently, it was suggested that P. acnes cells residing within the follicles grow as a biofilm...
  33. ncbi Acne and Propionibacterium acnes
    Richard A Bojar
    University of Leeds, Skin Research Centre, Division of Microbiology, Department of Biochemistry and Molecular Biology, LeedsLS2 9JT, UK
    Clin Dermatol 22:375-9. 2004
    ..acnes as a consequence of acne therapy not only has reopened the debate as to the role of P. acnes in acne, but also has created some serious health care implications...
  34. ncbi Structural fat grafting: more than a permanent filler
    Sydney R Coleman
    New York University School of Medicine, New York 10013, USA
    Plast Reconstr Surg 118:108S-120S. 2006
    ..Of particular interest is the research that has pointed to the use of stem cells to repair and even to become bone, cartilage, muscle, blood vessels, nerves, and skin. Further studies are essential to understand grafted fat tissue...
  35. ncbi Insights in the pathogenic potential of Propionibacterium acnes from its complete genome
    Holger Bruggemann
    Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, University of Gottingen, Gottingen, Germany
    Semin Cutan Med Surg 24:67-72. 2005
    ..Special attention has been drawn to the cell surface composition of P. acnes, its antigenic potential, and to enzymes that are potentially involved in degrading skin-derived substances...
  36. pmc Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo
    Sewon Kang
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA
    Am J Pathol 166:1691-9. 2005
    ..This new knowledge enables a rational strategy for development of pharmacological agents that can target the inflammation and matrix remodeling that occurs in severe acne...
  37. ncbi Role of hormones in pilosebaceous unit development
    D Deplewski
    Department of Medicine and Pediatrics, The University of Chicago Pritzker School of Medicine, Illinois 60637 1470, USA
    Endocr Rev 21:363-92. 2000
    ..and endocrinological basis of PSU development and the hormonal treatment of the PSU disorders hirsutism, acne vulgaris, and pattern alopecia are reviewed...
  38. ncbi A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial
    Robyn N Smith
    School of Applied Sciences, RMIT University, Melbourne, Australia
    Am J Clin Nutr 86:107-15. 2007
    ..Although the pathogenesis of acne is currently unknown, recent epidemiologic studies of non-Westernized populations suggest that dietary factors, including the glycemic load, may be involved...
  39. ncbi Acne vulgaris: a disease of Western civilization
    Loren Cordain
    Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA
    Arch Dermatol 138:1584-90. 2002
    In westernized societies, acne vulgaris is a nearly universal skin disease afflicting 79% to 95% of the adolescent population...
  40. ncbi Multimodal treatment of acne, acne scars and pigmentation
    Ava T Shamban
    Laser Institute for Derm and European Skin Care, 600 E, 2021 Santa Monica Boulevard, Santa Monica, CA 90404 2208, USA
    Dermatol Clin 27:459-71, vi. 2009
    ..Severe scarring caused by acne is associated with substantial physical and psychological distress, particularly in adolescents. This article reviews the causes of acne, the treatment options, and grading scales...
  41. ncbi High school dietary dairy intake and teenage acne
    Clement A Adebamowo
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Am Acad Dermatol 52:207-14. 2005
    ..We examined data from the Nurses Health Study II to retrospectively evaluate whether intakes of dairy foods during high school were associated with physician-diagnosed severe teenage acne...
  42. ncbi Role of the TNFA -308G > A polymorphism in the genetic susceptibility to acne vulgaris in a Sicilian population
    A Agodi
    Department GF Ingrassia, University of Catania, Italy
    Ann Ig 24:351-7. 2012
    b>Acne vulgaris is a common and clinically well-characterized skin disease that affects a great proportion of the general population and thus, is a major public health problem...
  43. ncbi Topical drug treatment in acne
    H Gollnick
    Department of Dermatology and Venereology Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    Dermatology 196:119-25. 1998
    ..Finally, liposome encapsulation of agents including phospholipids can enhance penetration and efficacy but, particularly with regard to retinoids, can lead to higher absorption and adverse drug reactions...
  44. pmc Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, California, USA
    J Invest Dermatol 129:2480-8. 2009
    ..acnes-induced ear swelling and granulomatous inflammation. The obtained data highlight the potential of using lauric acid as an alternative treatment for antibiotic therapy of acne vulgaris.
  45. ncbi Dramatic improvement of pyoderma gangrenosum with infliximab in a patient with PAPA syndrome
    Dorothee S Stichweh
    UT Southwestern Medical Center at Dallas and Texas Scottish Rite Hospital for Children, Dallas, Texas, USA
    Pediatr Dermatol 22:262-5. 2005
    ..A dramatic improvement in his pyoderma gangrenosum was observed after one infusion of infliximab, and a second infusion led to its resolution. Our observation extends the therapeutic use of infliximab to this component of PAPA syndrome...
  46. pmc Oxidative stress in patients with acne vulgaris
    Ozer Arican
    Department of Dermatology, Kahramanmaras Sutcuimam Medical Faculty, Turkey
    Mediators Inflamm 2005:380-4. 2005
    b>Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aim to determine the effects of oxidative stress in acne vulgaris...
  47. ncbi Novel topical drug delivery systems and their potential use in acne vulgaris
    M Taglietti
    Forest Research Institute, Jersey City, NJ, USA
    Skin Therapy Lett 13:6-8. 2008
    ....
  48. pmc Passive immunoprotection targeting a secreted CAMP factor of Propionibacterium acnes as a novel immunotherapeutic for acne vulgaris
    Pei Feng Liu
    Department of Medicine, Division of Dermatology, University of California, San Diego, San Diego, CA 92121, USA
    Vaccine 29:3230-8. 2011
    Propionibacterium acnes (P. acnes) bacteria play a key role in the pathogenesis of acne vulgaris. Although our previous studies have demonstrated that vaccines targeting a surface sialidase or bacterial particles exhibit a preventive ..
  49. ncbi Treating acne with antibiotic-resistant bacterial colonization
    Thrasivoulos Tzellos
    Dessau Medical Center, Departments of Dermatology, Venereology, Allergology and Immunology, Auenweg Dessau, Germany
    Expert Opin Pharmacother 12:1233-47. 2011
    ..Antibiotics have been the primary treatment against P. acnes for more than 40 years. However, a gradual increase in the prevalence of antibiotic-resistant strains of P. acnes has been observed...
  50. ncbi Acne sans P. acnes
    B Shaheen
    Department of Dermatology, Cardiff University, Cardiff
    J Eur Acad Dermatol Venereol 27:1-10. 2013
    b>Acne vulgaris is a common disease that carries an enormous financial and psychosocial impact...
  51. ncbi Body dysmorphic disorder symptoms among patients with acne vulgaris
    Whitney P Bowe
    Department of Dermatology, The Children s Hospital of Philadelphia, USA
    J Am Acad Dermatol 57:222-30. 2007
    ....
  52. ncbi Looking back to the future--acne
    W J Cunliffe
    Skin Research Centre, Department of Dermatology, The General Infirmary at Leeds, UK
    Dermatology 204:167-72. 2002
  53. ncbi Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study
    P Coates
    The Skin Research Centre, Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    Br J Dermatol 146:840-8. 2002
    ..Resistance in the target organism is a well-recognized consequence of antibiotic therapy for acne but formal prevalence and distribution data are lacking...
  54. ncbi The evolving role of Propionibacterium acnes in acne
    J J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia 19104, USA
    Semin Cutan Med Surg 20:139-43. 2001
    ..In the last decade, decreased sensitivity to antibiotics has developed and clinical resistance has been described. This development threatens the usefulness of antibiotic therapy in the future...
  55. pmc Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris
    Yipeng Wang
    Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
    PLoS ONE 6:e22120. 2011
    ..effectively killed other microorganisms including Staphylococcus epidermidis, which was possible pathogen for acne vulgaris. Cathelicidin-BF significantly inhibited pro-inflammatory factors secretion in human monocytic cells and P...
  56. pmc Psychological sequelae of acne vulgaris: results of a qualitative study
    Parker Magin
    University of Newcastle, Callaghan, Australia
    Can Fam Physician 52:978-9. 2006
    To investigate the psychological sequelae of acne vulgaris.
  57. ncbi Clinical considerations in the treatment of acne vulgaris and other inflammatory skin disorders: focus on antibiotic resistance
    James J Leyden
    Department of Dermatology, University of Pennsylvania, Philadelphia, USA
    Cutis 79:9-25. 2007
    ..By increasing our understanding of the multifaceted actions of antibiotics and the known clinical implications of antibiotic resistance, physicians can improve their decision making in prescribing these agents...
  58. ncbi A review of phytotherapy of acne vulgaris: perspective of new pharmacological treatments
    Hanieh Azimi
    Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Fitoterapia 83:1306-17. 2012
    ..This review focuses on plants currently used and those with a high potency for the future development of anti-acne products...
  59. ncbi Antibiotic resistance in Propionibacterium acnes. Microbiological and clinical aspects
    Carl Erik Nord
    Division of Clinical Bacteriology, Karolinska University Hospital, Karolinska Institute, SE 141 86 Stockholm, Sweden
    Anaerobe 12:207-10. 2006
  60. ncbi Expression of recombinant puroindolines for the treatment of staphylococcal skin infections (acne vulgaris)
    Rosanna Capparelli
    School of Biotechnological Sciences, University of Naples Federico II, via Università 133, Portici, 80055 Naples, Italy
    J Biotechnol 128:606-14. 2007
    ..Our preliminary results suggest that recombinant puroindolines deserve further attention as alternatives to the conventional antibiotics in the control of S. epidermidis skin infections...
  61. ncbi Modelling the remission of individual acne lesions in vitro
    M M T Downie
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital Box 232, Hills Road, Cambridge CB2 2QR, U K
    Br J Dermatol 147:869-78. 2002
    ..We have previously described the cytokines that will promote in vitro the lesions of acne...
  62. ncbi Mediterranean diet and familial dysmetabolism as factors influencing the development of acne
    Nevena Skroza
    Dermatology Unit D Innocenzi, Polo Pontino, Sapienza University of Rome, Rome, Italy
    Scand J Public Health 40:466-74. 2012
    ..To investigate the effects of adherence to the Mediterranean diet and familial dysmetabolisms on acne development...
  63. ncbi There is no correlation between acne severity and AQOLS/DLQI scores
    Ertam Ilgen
    Ege University Health, Culture and Sports Department, Izmir, Turkey
    J Dermatol 32:705-10. 2005
    ..For that reason, life quality of patients should be evaluated with psychiatric measurements other than AQOLS and DLQI. In conclusion, these scores are not good enough to evaluate acne patients's quality of life...
  64. pmc An expanded multilocus sequence typing scheme for propionibacterium acnes: investigation of 'pathogenic', 'commensal' and antibiotic resistant strains
    Andrew McDowell
    Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen s University, Belfast, United Kingdom
    PLoS ONE 7:e41480. 2012
    ..Collectively our data lends support to the view that pathogenic versus truly commensal lineages of P. acnes may exist. This is likely to have important therapeutic and diagnostic implications...
  65. ncbi High social phobia frequency and related disability in patients with acne vulgaris
    Yasin Bez
    Dicle University School of Medicine, Department of Psychiatry, Diyarbakir, Turkey
    Eur J Dermatol 21:756-60. 2011
    ..to determine the social phobia frequency, social anxiety level, and disease related disability in a group of acne vulgaris patients...
  66. ncbi Acne-associated syndromes: models for better understanding of acne pathogenesis
    W Chen
    Department of Dermatology and Allergy, Technische Universitaet Muenchen, Munich, Germany
    J Eur Acad Dermatol Venereol 25:637-46. 2011
    ..Advances in the understanding of the manifestation and molecular mechanisms of these syndromes will help to clarify acne pathogenesis and develop novel therapeutic modalities...
  67. ncbi Quality of life issues for South Africans with acne vulgaris
    A Mosam
    Department of Dermatology, Nelson R Mandela School of Medicine, University of Natal, South Africa
    Clin Exp Dermatol 30:6-9. 2005
    ..042 and P = 0.019, respectively. In conclusion, South African patients with acne vulgaris suffer significant psychological distress, which affects the quality of their lives.
  68. ncbi Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients: a randomized, controlled trial
    Hyuck Hoon Kwon
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea
    Acta Derm Venereol 92:241-6. 2012
    ..A reduction in glycaemic load of the diet for 10 weeks resulted in improvements in acne...
  69. ncbi Fractional photothermolysis for the treatment of postinflammatory erythema resulting from acne vulgaris
    Adrienne S Glaich
    DermSurgery Associates, Houston, Texas, USA
    Dermatol Surg 33:842-6. 2007
  70. ncbi Acne vulgaris: review and guidelines
    Marcia Ramos-E-Silva
    Sector of Dermatology, HUCFF UFRJ and School of Medicine, Federal University of Rio de Janeiro, Brazil
    Dermatol Nurs 21:63-8; quiz 69. 2009
    ..Some patients also need a hormonal and, sometimes, psychological evaluation. The right treatment for the right patient is key to treating acne safely...
  71. ncbi Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology?
    A S Karadag
    Department of Dermatology, Kecioren Research and Training Hospital, 06290 Keçiören, Ankara, Turkey
    Br J Dermatol 162:798-802. 2010
    Isotretinoin is an effective treatment for acne vulgaris. However, it has numerous side-effects. It was previously reported that serum growth hormone (GH) levels decreased with isotretinoin treatment.
  72. ncbi Effect of insulin-like growth factor-1 deficiency or administration on the occurrence of acne
    D Ben-Amitai
    Unit of Pediatric Dermatology, Schneider Children s Medical Center of Israel, Petach Tikva, Israel
    J Eur Acad Dermatol Venereol 25:950-4. 2011
    ..The role of growth hormone, insulin, and insulin-like growth factor-1 (IGF-1) in the development of acne is incompletely understood...
  73. ncbi The effective treatment of acne vulgaris by a high-intensity, narrow band 405-420 nm light source
    Monica Elman
    Beit Harofim Holon, Israel
    J Cosmet Laser Ther 5:111-7. 2003
    ..A novel, high-intensity, narrow band 420 nm UV free blue light has been shown to decrease inflammatory acne lesions after eight bi-weekly treatments...
  74. ncbi Prevalence of acne and its impact on the quality of life in school-aged adolescents in Malaysia
    Arshad Hanisah
    Muar District of Health, Muar, Johor, Malaysia
    J Prim Health Care 1:20-5. 2009
    ..The objective of this study was to determine the prevalence of facial acne and its impact on the quality of life among adolescents attending secondary schools in Muar, Malaysia...
  75. ncbi Effects of skin care and makeup under instructions from dermatologists on the quality of life of female patients with acne vulgaris
    Yoshie Matsuoka
    Department of Dermatology, Faculty of Medicine, Kagawa University, Kita gun, Japan
    J Dermatol 33:745-52. 2006
    b>Acne vulgaris significantly affects patients' quality of life (QOL) and their lives in various ways, including social behavior and body dissatisfaction. This may be heightened by acne's typical involvement of the face...
  76. ncbi An assessment of the efficacy of blue light phototherapy in the treatment of acne vulgaris
    Sadia Ammad
    Cardiff University, Cardiff, UK
    J Cosmet Dermatol 7:180-8. 2008
    b>Acne vulgaris is a common skin condition that affects 8 out of 10 people. It varies from mild to severe, and different treatments target various aspects of the disease...
  77. ncbi Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study
    Gabriella Fabbrocini
    Department of Systematic Pathology, Division of Clinical Dermatology, University of Naples Federico II, Via S Pansini 5, Naples, Italy
    Am J Clin Dermatol 12:133-41. 2011
    b>Acne vulgaris is a complex, chronic, and common skin disorder of pilosebaceous units...
  78. pmc IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway
    Terry M Smith
    The Jake Gittlen Cancer Research Foundation, Hershey, Pennsylvania, USA
    J Invest Dermatol 128:1286-93. 2008
    ..Specific targeted interruption of this pathway in the sebaceous gland could be a desirable approach to reducing sebum production and improving acne...
  79. ncbi Make-up improves the quality of life of acne patients without aggravating acne eruptions during treatments
    Nobukazu Hayashi
    Department of Dermatology, Tokyo Women s Medical University, Kawada cho 8 1, Shinjuku ku, Tokyo, 162 8666, Japan
    Eur J Dermatol 15:284-7. 2005
    ..The QOL scores of Skindex-16, GHQ30 and anxiety state index greatly improved. Our results suggest that dermatologists should encourage acne patients to utilize appropriate make-up to improve their QOL...
  80. ncbi Quality of life in mild to moderate acne: relationship to clinical severity and factors influencing change with treatment
    M Jones-Caballero
    Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain
    J Eur Acad Dermatol Venereol 21:219-26. 2007
    Because of its effects on quality of life, acne vulgaris is more than a merely physiological or cosmetic entity.
  81. ncbi FoxO1 - the key for the pathogenesis and therapy of acne?
    Bodo C Melnik
    Department of Dermatology, Enviromental Medicine and Health Theory, University of Osnabruck, Germany
    J Dtsch Dermatol Ges 8:105-14. 2010
    ..Various receptor-mediated growth factor signals are integrated at the level of PI3K/Akt activation which finally results in nuclear FoxO1 deficiency...
  82. pmc Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-defensin-2 expression
    Teruaki Nakatsuji
    Division of Dermatology, Department of Medicine, University of California, San Diego, San Diego, California 92161, USA
    J Invest Dermatol 130:985-94. 2010
    ..This report highlights the potential of using FFAs as a multifunctional antimicrobial therapy agent for acne vulgaris treatment; FFAs may provide direct antibacterial activities against P...
  83. ncbi Coping with acne: beliefs and perceptions in a sample of secondary school Greek pupils
    D Rigopoulos
    University of Athens, Department of Dermatology, A Sygros Hospital, Athens, Greece
    J Eur Acad Dermatol Venereol 21:806-10. 2007
    ..Information on the understanding of acne in adolescents has only occasionally been reported in the medical literature...
  84. ncbi Role of hormones in acne vulgaris
    Megha Kataria Arora
    Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India
    Clin Biochem 44:1035-40. 2011
    To elucidate the role of endogenous hormones like testosterone, progesterone, estrogen, insulin-like growth factor, insulin and glucocorticoids in a common skin condition acne vulgaris.
  85. ncbi Prevalence of polycystic ovary syndrome and related disorders in mexican women
    Carlos Moran
    Direction of Health Research and Training, Medical Unit of High Specialty in Gynecology and Obstetrics No 4 Luis Castelazo Ayala, Mexico City, Mexico
    Gynecol Obstet Invest 69:274-80. 2010
    ..Polycystic ovary syndrome (PCOS) has been found to affect 4-8% of women of reproductive age; however, in Mexican-Americans a prevalence of 12.8% has been reported. This study determines the prevalence of PCOS in a sample of Mexican women...
  86. ncbi Pathogenesis of acne
    M Toyoda
    Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
    Med Electron Microsc 34:29-40. 2001
    b>Acne vulgaris is a skin disorder of the sebaceous follicles that commonly occurs in adolescence and in young adulthood...
  87. ncbi Comparison of the efficacy and safety of a combination topical gel formulation of benzoyl peroxide and clindamycin with benzoyl peroxide, clindamycin and vehicle gel in the treatments of acne vulgaris
    J J Leyden
    Department of Dermatology, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA
    Am J Clin Dermatol 2:33-9. 2001
    ..Topical clindamycin and benzoyl peroxide have each demonstrated clinical efficacy in the treatment of acne vulgaris. When used in combination, they promise greater efficacy than either individual agent used alone and the ..
  88. ncbi Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris
    Bodo C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Osnabruck, Germany
    Exp Dermatol 18:833-41. 2009
    ..Persistent acne in adulthood with high IGF-1 levels may be considered as an indicator for increased risk of cancer, which may require appropriate dietary intervention as well as treatment with insulin-sensitizing agents...
  89. ncbi An epidemiological study of acne in female adults: results of a survey conducted in France
    F Poli
    Hĵpital Henri Mondor, Service de Dermatologie, Creteil, France
    J Eur Acad Dermatol Venereol 15:541-5. 2001
    ..For most patients, acne did not severely impair their quality of life. CONCLUSION: This study shows a prevalence of acne in 41% of women in the general population. A high proportion of these acne cases are late onset acne...
  90. ncbi Milk consumption and acne in adolescent girls
    Clement A Adebamowo
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Dermatol Online J 12:1. 2006
    ..We found a positive association between intake of milk and acne. This finding supports earlier studies and suggests that the metabolic effects of milk are sufficient to elicit biological responses in consumers...
  91. ncbi Milk consumption and acne in teenaged boys
    Clement A Adebamowo
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    J Am Acad Dermatol 58:787-93. 2008
    ..We sought to examine the association between dietary dairy intake and teenaged acne among boys...
  92. ncbi Acne prevalence, knowledge about acne and psychological morbidity in mid-adolescence: a community-based study
    A Smithard
    Behavioural Sciences Section, Division of Psychiatry, A Floor, Queens Medical Centre, Nottingham NG7 2UH, UK
    Br J Dermatol 145:274-9. 2001
    BACKGROUND: Acne vulgaris is a distressing condition that affects the majority of adolescents, but its impact on mental health in this age group is poorly understood...
  93. ncbi Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions
    C M Chronnell
    Centre for Cutaneous Research, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, London, UK
    J Invest Dermatol 117:1120-5. 2001
    ..Although the basic mechanisms involved in the development of inflammation during acne vulgaris remain unclear, microbial agents might play an important role in this process...
  94. ncbi Management of acne vulgaris: an evidence-based update
    J R Ingram
    Welsh Institute of Dermatology, University Hospital of Wales, Cardiff, UK
    Clin Exp Dermatol 35:351-4. 2010
    ..the 62 randomized controlled trials (RCTs) published between February 2007 and January 2009 on the topic of acne vulgaris. Low glycaemic-load diets might reduce acne severity but this remains unproven...
  95. ncbi Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapy
    Uta Jappe
    Department of Dermatology and Venereology, University of Heidelberg, Germany
    Acta Derm Venereol 83:241-8. 2003
    ..The aim of this review is to summarize the data on aetiopathological factors in acne and their contribution to acne pathology and therapy...
  96. ncbi Not just 'skin deep': psychosocial effects of dermatological-related social anxiety in a sample of acne patients
    Tom Loney
    University of Bath, Claverton Down, Bath, UK
    J Health Psychol 13:47-54. 2008
    ..The current findings suggest that how one perceives their skin to be evaluated by others has implications for self-perceptions and may act as a barrier to sport/exercise participation...
  97. ncbi Current concepts of the pathogenesis of acne: implications for drug treatment
    Harald Gollnick
    University Clinic for Dermatology and Venereology, Otto von Guericke University, Magdeburg, Germany
    Drugs 63:1579-96. 2003
    ..When added to antibacterial therapy, topical retinoids demonstrate faster and significantly greater reduction of inflammatory acne lesions and comedones than antibacterials alone...
  98. ncbi Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study
    Vijay Kumar Garg
    Department of Dermatology, Venereology and Leprology, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India
    Dermatol Surg 35:59-65. 2009
    ..Salicylic-mandelic acid combination peels (SMPs) are a newer modality, and there have been no well-controlled studies comparing them with other conventional agents...
  99. ncbi Nutrition and acne
    F William Danby
    Department of Medicine, Section of Dermatology, Dartmouth Medical School, Manchester, NH 03104, USA
    Clin Dermatol 28:598-604. 2010
    ....
  100. ncbi The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action
    B C Melnik
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabruck, Germany
    G Ital Dermatol Venereol 145:559-71. 2010
    ..of this review to demonstrate that oral isotretinoin treatment restores all major pathogenetic factors of acne vulgaris by upregulation of the nuclear transcription factor FoxO1, which will be shown to be the major target of ..
  101. ncbi Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris
    Monica Ottaviani
    San Gallicano Dermatological Institute IRCCS, Rome, Italy
    J Invest Dermatol 126:2430-7. 2006
    ..Inflammatory processes play an important role in the development of acne vulgaris. In combination with our own previous findings, which indicated an association between LOX stimulation and ..

Research Grants37

  1. A Soft Topical Antiandrogenic Drug
    Wei Chu Xu; Fiscal Year: 2013
    ..The overproduction of androgens in both sexes is the root cause of most acne (acne vulgaris), alopecia and seborrhea, and the practice of using antiandrogenic therapy in these disorders is accepted...
  2. Innate Immunity in Acne Vulgaris
    Jenny J Kim; Fiscal Year: 2013
    ..This "double- edged sword" of innate immunity is clearly evident in acne vulgaris in which innate immune cells mount an antimicrobial response to P...
  3. Development of Clinical Trials Outcome Instruments for Acne Vulgaris
    Diane M Thiboutot; Fiscal Year: 2013
    ..Teams are based in the US (Drs. Thiboutot/Chren);the UK (Drs.Layton/Eady) and Canada (Drs.Tan/Wolfe). Global communication strategies will supplement face-to-face meetings and Six Sigma principles of project management will be employed. ..
  4. ANDROGEN REGULATION OF HUMAN SEBACEOUS GLANDS
    Diane Thiboutot; Fiscal Year: 2001
    ..Androgens are thought to modulate sebum production by the SG and, thereby, to contribute to the development of acne vulgaris, a prevalent disease associated with significant physical and psychological morbidity...
  5. EVALUATION OF PATHOGENIC FACTORS IN ACNE VULGARIS
    DONALD DOWNING; Fiscal Year: 1991
    ....
  6. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..Excessive 5alpha-reductase activity is found in acne vulgaris as well as androgenic alopecia (male pattern baldness)...
  7. LASER TREATMENT OF ACNE BY INJURY TO SEBACEOUS GLANDS
    DILIP PAITHANKAR; Fiscal Year: 2000
    ..Phase-II proposal emphasizing the development of a commercially oriented laser system for the treatment for acne vulgaris. PROPOSED COMMERCIAL APPLICATIONS: This research could lead to the development of a significantly improved ..
  8. NEW DRUGS FOR THE TREATMENT OF ACNE, REVISED PLAN
    Joseph Dunn; Fiscal Year: 2001
    ..acnes, a microbe that has been implicated in the pathogenesis of acne vulgaris. The investigators propose that this chemical may be useful as a topical anti-acne preparation...
  9. GRANULYSIN: ANTIMICROBIAL/ANTI-INFLAMMATORY ROLE IN ACNE
    Robert Modlin; Fiscal Year: 2009
    ..These studies will have the potential to develop a new class of antibiotic compounds for use in the treatment of cutaneous infections ncluding acne vulgaris as well as other skin infections in which bacteria are involved.
  10. Conference--Dermatologic Disease in Skin of Color
    Susan Taylor; Fiscal Year: 2002
    ..They believe that these presentations and discussions will lead to a greater interest in the specific problem related to access to care for dermatologic disease among persons of color. ..
  11. Benzodiazepine Receptor in PTSD
    JAMES BREMNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2008
    ..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
  13. Innate and Adaptive Immunity in Acne Vulgaris
    Jenny Kim; Fiscal Year: 2006
    ..Better understanding of the innate and adaptive immune mechanisms against P. acnes could provide insight into host defense mechanisms in skin and suggest development of novel avenues of immunologic intervention in acne. ..
  14. Long-Circulating Liposomal Camptothecins CAP and EAP
    Roman Perez Soler; Fiscal Year: 2003
    ..Ultimately, we will seek formulation(s) that display optimized drug retention and in vivo and in vitro performance. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  15. Cutaneous Host Defense Against Bacterial Infections
    Lloyd Miller; Fiscal Year: 2008
    ..abstract_text> ..
  16. Nitric Oxide Synthase Polymorphisms and Risk for Skin Cancer
    Abrar Qureshi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Mechanism of Action of Inhibitory CpG Oligonucleotides
    Petar Lenert; Fiscal Year: 2009
    ..abstract_text> ..
  18. Determinants of Resistance to Erlotinib in NSCLC
    Roman Perez Soler; Fiscal Year: 2010
    ..To confirm the predictive value of the algorithm in a group of patients with chemoresistant NSCLC selected for their high probability of achieving a response or stable disease with single agent erlotinib therapy. ..
  19. Phase III Study of Donepezil in the Irradiated Brain
    Stephen R Rapp; Fiscal Year: 2010
    ..If successful the study will offer physicians a treatment for radiation-induced cognitive impairment which also may improve mood and quality of life. ..
  20. FREE PLASMA SEX HORMONE AND ANDROGEN ACTION
    Robert Rosenfield; Fiscal Year: 2001
    ....
  21. NEUTROPHINS AND RETINAL DEVELOPMENT
    Janet Sparrow; Fiscal Year: 2001
    ..The use of neurotrophins in conjunction with gene therapy or transplantation may also have potential for reversing retinal degenerative changes and lead to the restoration of vision. ..
  22. Therapeutic use of inhibitory DNA sequences in animal models of lupus
    Petar Lenert; Fiscal Year: 2006
    ..Future extension of these studies to humans may lead to the design of novel therapeutic agents for human SLE. [unreadable] [unreadable] [unreadable]..
  23. INNOVATIVE TUMOR TARGETED THERAPIES FOR LUNG CANCER
    Roman Perez Soler; Fiscal Year: 2004
    ..Four such candidates have already been identified. It is anticipated that a total of ten young clinical investigators will be mentored during a five-year period. ..
  24. CATIONIC LIPID/P53 GENE THERAPY IN LUNG CANCER PATIENTS
    Roman Perez Soler; Fiscal Year: 2003
    ..The results of this study will provide initial but very valuable information on the potential use of this new strategy in the treatment of bronchial premalignancy, carcinoma in situ, and endobronchial lung tumors. ..
  25. Urinary Symptoms in Adolescent Females: STI or UTI?
    Jill Huppert; Fiscal Year: 2004
    ..The findings of this study will strengthen the evidence base for symptom-based STI testing of SA adolescent females and will promote care that addresses both individual patient and public health needs. ..
  26. The Molecular Basis of Ovarian Testosterone Production
    Robert Rosenfield; Fiscal Year: 2004
    ..The overall goal of this proposal is to understand the factors regulating the production of testosterone in women, particularly in their ovaries. ..
  27. CLINICAL TRANSLATIONAL RESEARCH IN DERMATOLOGY
    Sewon Kang; Fiscal Year: 2004
    ..abstract_text> ..
  28. Chemotherapy and anti-EGFR Antibody C225 in Lung Cancer
    Roman Perez Soler; Fiscal Year: 2004
    ..abstract_text> ..
  29. CONFOCAL HISTOPATHOLOGY OF CONTACT DERMATITIS IN VIVO
    Salvador Gonzalez; Fiscal Year: 2002
    ..We also expect that our results may ultimately translate into more rational and effective care for patients with this common and frequently disabling problem. ..
  30. UV-induced collagen reduction: treating skin scleroderma
    Sewon Kang; Fiscal Year: 2005
    ....
  31. Role of PPAR Gamma Amino-Terminus in the Adipocyte
    Dianne Deplewski; Fiscal Year: 2007
    ..3) To use transgenic techniques to develop mice with a Ser112Ala mutation in PPARgamma2. The degree of obesity and insulin sensitivity will be further studied in these mice. ..
  32. Effect of hormonal contraception on bone mineral density
    Abbey Berenson; Fiscal Year: 2005
    ..Ultimately, this study will determine which women, if any, are placed at increased risk of osteopenia or osteoporosis as a result of using these hormonal contraceptives during their reproductive years. ..