skin diseases

Summary

Top Publications

  1. ncbi Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?
    Thomas Grobner
    Department of Nephrology, General Hopsital of Wiener Neustadt, A 2700 Wiener Neustadt, Austria
    Nephrol Dial Transplant 21:1104-8. 2006
  2. ncbi Basophil recruitment and activation in inflammatory skin diseases
    Y Ito
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Allergy 66:1107-13. 2011
  3. ncbi Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet
    Giuseppe Argenziano
    Department of Dermatology, Second University of Naples, Italy
    J Am Acad Dermatol 48:679-93. 2003
  4. ncbi Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging
    Peter Marckmann
    Department of Nephrology, Copenhagen University Hospital at Herlev, DK 2730 Herlev, Denmark
    J Am Soc Nephrol 17:2359-62. 2006
  5. ncbi Improved discriminative and evaluative capability of a refined version of Skindex, a quality-of-life instrument for patients with skin diseases
    M M Chren
    Dermatology Service, Cleveland Veterans Affairs Medical Center, Ohio, USA
    Arch Dermatol 133:1433-40. 1997
  6. pmc Dermatological phenotype in Costello syndrome: consequences of Ras dysregulation in development
    D H Siegel
    Department of Dermatology and Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road TBRC, 2nd Floor, Suite C2010, Milwaukee, WI 53226, USA
    Br J Dermatol 166:601-7. 2012
  7. ncbi Antioxidant activity, lipid peroxidation and skin diseases. What's new
    S Briganti
    Cutaneous Physiopathology Laboratory, San Gallicano Dermatological Institute, 25 A Via S Gallicano, 00153 Rome, Italy
    J Eur Acad Dermatol Venereol 17:663-9. 2003
  8. ncbi Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases
    Ryuhei Okuyama
    Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Dermatol Sci 49:187-94. 2008
  9. ncbi Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan
    Arshad Mehmood Abbasi
    Department of Plant Sciences, Quaid i Azam University, Islamabad 45320, Pakistan
    J Ethnopharmacol 128:322-35. 2010
  10. ncbi Photoprotective potential of strawberry (Fragaria × ananassa) extract against UV-A irradiation damage on human fibroblasts
    Francesca Giampieri
    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Universita Politecnica delle Marche, Ancona, Italy
    J Agric Food Chem 60:2322-7. 2012

Detail Information

Publications356 found, 100 shown here

  1. ncbi Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?
    Thomas Grobner
    Department of Nephrology, General Hopsital of Wiener Neustadt, A 2700 Wiener Neustadt, Austria
    Nephrol Dial Transplant 21:1104-8. 2006
  2. ncbi Basophil recruitment and activation in inflammatory skin diseases
    Y Ito
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Allergy 66:1107-13. 2011
    ..However, basophil infiltration into the tissues in human skin diseases remains to be addressed.
  3. ncbi Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet
    Giuseppe Argenziano
    Department of Dermatology, Second University of Naples, Italy
    J Am Acad Dermatol 48:679-93. 2003
    ..There is a need for better standardization of the dermoscopic terminology in assessing pigmented skin lesions...
  4. ncbi Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging
    Peter Marckmann
    Department of Nephrology, Copenhagen University Hospital at Herlev, DK 2730 Herlev, Denmark
    J Am Soc Nephrol 17:2359-62. 2006
    ..No other exposure/event than gadodiamide that was common to more than a minority of the patients could be identified. These findings indicate that gadodiamide plays a causative role in nephrogenic systemic fibrosis...
  5. ncbi Improved discriminative and evaluative capability of a refined version of Skindex, a quality-of-life instrument for patients with skin diseases
    M M Chren
    Dermatology Service, Cleveland Veterans Affairs Medical Center, Ohio, USA
    Arch Dermatol 133:1433-40. 1997
    ..To improve Skindex, a dermatologic quality-of-life instrument...
  6. pmc Dermatological phenotype in Costello syndrome: consequences of Ras dysregulation in development
    D H Siegel
    Department of Dermatology and Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road TBRC, 2nd Floor, Suite C2010, Milwaukee, WI 53226, USA
    Br J Dermatol 166:601-7. 2012
    ..Costello syndrome (CS) is a RASopathy caused by mutations in the HRAS gene, a key regulator of signal transduction...
  7. ncbi Antioxidant activity, lipid peroxidation and skin diseases. What's new
    S Briganti
    Cutaneous Physiopathology Laboratory, San Gallicano Dermatological Institute, 25 A Via S Gallicano, 00153 Rome, Italy
    J Eur Acad Dermatol Venereol 17:663-9. 2003
    ..are polyunsaturated fatty acids and theirs oxidation products, have a central role in the induction of some skin diseases, such as psoriasis or acne, has indicated new links between free radicals and skin inflammation...
  8. ncbi Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases
    Ryuhei Okuyama
    Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    J Dermatol Sci 49:187-94. 2008
    ..Future efforts to further define how Notch controls cell proliferation and differentiation may lead to the application of Notch in new therapies for various skin diseases.
  9. ncbi Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan
    Arshad Mehmood Abbasi
    Department of Plant Sciences, Quaid i Azam University, Islamabad 45320, Pakistan
    J Ethnopharmacol 128:322-35. 2010
    The present investigation is an attempt to find out ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics.
  10. ncbi Photoprotective potential of strawberry (Fragaria × ananassa) extract against UV-A irradiation damage on human fibroblasts
    Francesca Giampieri
    Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Universita Politecnica delle Marche, Ancona, Italy
    J Agric Food Chem 60:2322-7. 2012
    ..is known to induce discrete lesions in DNA and the generation of free radicals that lead to a wide array of skin diseases. Strawberry (Fragaria × ananassa) contains several polyphenols with strong antioxidant and anti-inflammatory ..
  11. ncbi Differential in situ expression of IL-17 in skin diseases
    Mattias Fischer-Stabauer
    Department of Dermatology and Allergy, Technische Universität and Helmholtz Center Munich, Biedersteiner Straße 29, Munich, Germany
    Eur J Dermatol 22:781-4. 2012
    ..Interleukin (IL)-17 is a key molecule for epithelial immunity and inflammation...
  12. ncbi Systemic ciclosporin and tacrolimus in dermatology
    V Madan
    The Dermatology Center, University of Manchester, Hope Hospital, Salford, Manchester, UK
    Dermatol Ther 20:239-50. 2007
    ..However, there are several case studies and anecdotal reports of the successful use of oral tacrolimus in various dermatoses. In this article we discuss the utility of systemic ciclosporin and tacrolimus in dermatology...
  13. ncbi Mechanisms of cutaneous toxicities to EGFR inhibitors
    Mario E Lacouture
    SERIES Clinic and Cancer Skin Care Program, Department of Dermatology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Suite 1600, Chicago, Illinois 60611, USA
    Nat Rev Cancer 6:803-12. 2006
    ..There is an urgent need for an improved understanding of these toxicities to develop adequate staging systems and mechanistically driven therapies, and to ensure quality of life and consistent antineoplastic therapy...
  14. ncbi Photoageing: mechanism, prevention and therapy
    M Yaar
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118 2394, USA
    Br J Dermatol 157:874-87. 2007
    ..Such advances should not only allow for the improved appearance of skin in middle age and beyond, but also greatly reduce the accompanying burden of skin cancer...
  15. ncbi Measurement properties of Skindex-16: a brief quality-of-life measure for patients with skin diseases
    M M Chren
    Department of Dermatology, University of California at San Francisco, San Francisco, California, USA
    J Cutan Med Surg 5:105-10. 2001
    ..An accurate, sensitive, but brief quality-of-life outcomes measure is needed for studies of dermatologic care...
  16. ncbi Cutaneous sarcoidosis occurring during anti-TNF-alpha treatment: report of two cases
    F Dhaille
    Department of Dermatology, Amiens University Medical Centre, South Hospital, Amiens, France Florie Dhaille orange fr
    Dermatology 220:234-7. 2010
    ..The biospies confirmed the diagnosis of a 'sarcoidosis-like' reaction. No systemic involvement was observed. Such cases of noninfectious granulomatous diseases occurring during anti-TNF-alpha therapy are becoming increasingly frequent...
  17. ncbi Folk phytotherapeutical plants from Maratea area (Basilicata, Italy)
    Paolo Maria Guarrera
    Museo Nazionale Arti e Tradizioni Popolari, Piazza Marconi 8 10, 00144 Rome, Italy
    J Ethnopharmacol 99:367-78. 2005
    ..graeca (coughs) and Ceterach officinarum (malaria), while in the ethnoveterinary field, we have Pteridium aquilinum (wolf bites) and Spartium junceum (fractures of animal limbs)...
  18. ncbi Induction of GVHD-like skin disease by passively transferred CD8(+) T-cell receptor transgenic T cells into keratin 14-ovalbumin transgenic mice
    Akihiko Shibaki
    Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Invest Dermatol 123:109-15. 2004
    ....
  19. ncbi Nephrogenic systemic fibrosis: risk factors and incidence estimation
    Elizabeth A Sadowski
    Department of Radiology, University of Wisconsin, Madison, WI 53792 3252, USA
    Radiology 243:148-57. 2007
    ..To retrospectively review data in 13 patients with biopsy-confirmed nephrogenic systemic fibrosis (NSF), assess the associated risk factors, and report the incidence of NSF at the authors' institution...
  20. ncbi Neurological symptoms and natural course of xeroderma pigmentosum
    Anu Anttinen
    Department of Neurology, Turku University Central Hospital, PB 52, 20521 Turku, Finland
    Brain 131:1979-89. 2008
    ....
  21. pmc A prospective study of arsenic exposure from drinking water and incidence of skin lesions in Bangladesh
    Maria Argos
    Department of Health Studies, The University of Chicago, Illinois 60637, USA
    Am J Epidemiol 174:185-94. 2011
    ..Chronic arsenic exposure from drinking water was associated with increased incidence of skin lesions, even at low levels of arsenic exposure (<100 μg/L)...
  22. ncbi Critical review of generic and dermatology-specific health-related quality of life instruments
    Hilde Both
    Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands
    J Invest Dermatol 127:2726-39. 2007
    The measurement of health-related quality of life (HRQOL) is increasingly important in patients with skin diseases. Despite the availability of a variety of instruments and new psychometric techniques, there is no consensus as to which ..
  23. ncbi Sarcoid-like granulomatosis in patients treated with tumor necrosis factor blockers: 10 cases
    Claire Immediato Daïen
    CHU Lapeyronie, Service d Immuno Rhumatologie, Montpellier, France
    Rheumatology (Oxford) 48:883-6. 2009
    ..However, several cases of sarcoidosis have been diagnosed during anti-TNF therapy. Here, we report the largest series of sarcoid-like granulomatosis following TNF blocker treatment...
  24. pmc Zebrafish: a model system to study heritable skin diseases
    Qiaoli Li
    Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 131:565-71. 2011
    Heritable skin diseases represent a broad spectrum of clinical manifestations due to mutations in ∼500 different genes. A number of model systems have been developed to advance our understanding of the pathomechanisms of genodermatoses...
  25. ncbi Adverse effects of topical glucocorticosteroids
    Ulrich R Hengge
    Department of Dermatology, Heinrich Heine University Duesseldorf, Germany
    J Am Acad Dermatol 54:1-15; quiz 16-8. 2006
    ..The authors provide an updated review of local and systemic adverse effects upon administration of topical corticosteroids, including the latest FDA report on the safety of such steroids in children...
  26. ncbi A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh
    Wendy J Verret
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    J Occup Environ Med 47:1026-35. 2005
    ..We sought to determine whether supplementation of vitamin E (alpha-tocopherol), selenium (L-selenomethionine), or their combination improves arsenical skin lesions...
  27. ncbi Gap junctions: basic structure and function
    Gulistan Mese
    1Program in Genetics, Stony Brook University, Stony Brook, New York, USA
    J Invest Dermatol 127:2516-24. 2007
    ..Here, we discuss the basic structure of gap junction channels and the function of connexin genes that have been associated with human disorders to explore the physiology of intercellular communication in skin...
  28. pmc Revertant mosaicism in skin: natural gene therapy
    Joey E Lai-Cheong
    St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, Floor 9 Tower Wing, King s College London Guy s Campus, London SE1 9RT, United Kingdom
    Trends Mol Med 17:140-8. 2011
    ..This overview highlights the latest developments in revertant mosaicism and the translational implications germane to heritable skin disorders...
  29. ncbi Effects of epidermal growth factor receptor inhibitor-induced dermatologic toxicities on quality of life
    Smita S Joshi
    Skin and Eye Reactions to Inhibitors of Epidermal Growth Factor Receptor and Kinase SERIES Clinic and Cancer Skin Care Program, Department of Dermatology and Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Cancer 116:3916-23. 2010
    ..By using a dermatology-specific questionnaire, the authors examined the effect of these toxicities on QoL...
  30. ncbi Frontiers in sebaceous gland biology and pathology
    Christos C Zouboulis
    Department of Dermatology, Dessau Medical Center, Dessau, Germany
    Exp Dermatol 17:542-51. 2008
    ..These multiple homeostatic functions award the sebaceous gland the role 'brain of the skin' and the most important cutaneous endocrine gland...
  31. ncbi Cytochrome p450: a target for drug development for skin diseases
    Nihal Ahmad
    Department of Dermatology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    J Invest Dermatol 123:417-25. 2004
    ..In addition, in some skin diseases, for example in psoriasis, many CYP are elevated...
  32. ncbi Managing treatment side effects in advanced breast cancer
    Susan Moore
    CancerExpertise, Chicago, IL 60641 3228, USA
    Semin Oncol Nurs 23:S23-30. 2007
    ..To compare and contrast the side-effect profiles of antineoplastic therapy options used in the treatment of metastatic breast cancer...
  33. ncbi Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors
    S Segaert
    Department of Dermatology, University Hospital, Katholieke Universiteit Leuven, Belgium
    Ann Oncol 16:1425-33. 2005
    ..This review outlines the broad spectrum of cutaneous side-effects of EGFR inhibitors, discusses possible underlying mechanisms and provides practical guidelines for the management based on literature data and on personal experience...
  34. pmc National athletic trainers' association position statement: skin diseases
    Steven M Zinder
    The University of North Carolina at Chapel Hill, USA
    J Athl Train 45:411-28. 2010
    ..To present recommendations for the prevention, education, and management of skin infections in athletes...
  35. ncbi Microbiome and skin diseases
    Patrick L J M Zeeuwen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Allergy Clin Immunol 13:514-20. 2013
    This article reviews recent findings on the skin microbiome. It provides an update on the current understanding of the role of microbiota in healthy skin and in inflammatory and allergic skin diseases.
  36. ncbi Epidemiology of skin diseases in ethnic populations
    Susan C Taylor
    Skin of Color Center, St Luke s Roosevelt Hospital Center, 1090 Amsterdam Avenue, Suite 1l D, New York, NY 10025, USA
    Dermatol Clin 21:601-7. 2003
    ..Many skin diseases are seemingly common to most of the ethnic populations, however, including blacks, Hispanics, Asians, and ..
  37. ncbi Synthesis and structure-activity relationships of skin ceramides
    J Novotny
    Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Heyrovskeho 1203, 50005 Hradec Kralove, Czech Republic
    Curr Med Chem 17:2301-24. 2010
    ..Moreover, prominent skin diseases such as psoriasis and atopic dermatitis are associated with diminished ceramide levels and may be effectively ..
  38. ncbi Common burden of chronic skin diseases? Contributors to psychological distress in adults with psoriasis and atopic dermatitis
    A W M Evers
    Department of Medical Psychology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    Br J Dermatol 152:1275-81. 2005
    Chronic skin diseases, such as atopic dermatitis and psoriasis, are known to affect quality of life by heightening psychological distress...
  39. ncbi Cutaneous manifestations in renal transplant recipients of Santiago, Chile
    M Sandoval
    Department of Dermatology, Pontificia Universidad Catolica de Chile, Chile
    Transplant Proc 41:3752-4. 2009
    ..These manifestations differ depending on the evaluated population. The objective of this study was to describe the prevalence of cutaneous manifestations among renal transplant recipients in Chile between 1979 and 2008...
  40. pmc Community based study to compare the incidence and health services utilization pyramid for gastrointestinal, respiratory and dermal symptoms
    Nusrat Najnin
    Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
    BMC Health Serv Res 12:211. 2012
    ..The aim of this study was to describe the epidemiology and rate these three major symptom complexes in order to improve our understanding of the health burden imposed by these symptoms...
  41. ncbi Development of cutaneous sarcoidosis during treatment with tumour necrosis alpha factor antagonists
    Edwina Lamrock
    Department of Dermatology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Australas J Dermatol 53:e87-90. 2012
    ..We present an unusual case of limited cutaneous sarcoidosis developing while the patient was on etanercept therapy, and a review of the current literature...
  42. ncbi Prevalence of skin disease among school children and adolescents in a Student Health Service Center in Hong Kong
    W K Fung
    Social Hygiene Service, Department of Health, Hong Kong
    Pediatr Dermatol 17:440-6. 2000
    ..In this study, the differences in prevalence of skin diseases between these two groups are pointed out...
  43. ncbi Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy
    Dorothee Twardella
    German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Radiother Oncol 69:145-53. 2003
    ..The influence of therapy modalities, personal characteristics and individual DNA repair capacity on the risk of acute skin toxicity was thus evaluated...
  44. ncbi Mast cells and immunological skin diseases
    Daniel Navi
    Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA 95816, USA
    Clin Rev Allergy Immunol 33:144-55. 2007
    ..article reviews the literature on the role of this cell type in the pathogenesis of a number of immunological skin diseases, including contact dermatitis, atopic dermatitis, immunobullous disease, scleroderma, and chronic graft-vs...
  45. ncbi IL-21 in the pathogenesis and treatment of skin diseases
    Antonio Costanzo
    Dermatology Unit, Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
    J Dermatol Sci 60:61-6. 2010
    ..Many of these activities are critically involved in the pathogenesis of several skin diseases such as psoriasis, atopic dermatitis, lupus erythematosus, and melanoma...
  46. ncbi Epidemiological pattern of tattoo skin disease: a potential general health indicator for cetaceans
    Marie Françoise Van Bressem
    Cetacean Conservation Medicine Group, CEPEC, Museo de Delfines, Pucusana, Lima 20, Peru
    Dis Aquat Organ 85:225-37. 2009
    ..The epidemiological pattern of TSD may be an indicator of cetacean population health...
  47. ncbi Epidemiology of skin diseases in school children: a study from northern India
    Sunil Dogra
    Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Pediatr Dermatol 20:470-3. 2003
    ..overcrowding, and poor standards of hygiene are important factors accounting for the distribution of skin diseases in developing countries such as India...
  48. ncbi Beneficial role of curcumin in skin diseases
    Rajesh L Thangapazham
    Uniformed Services University of Health Sciences, Bethesda, MD, USA
    Adv Exp Med Biol 595:343-57. 2007
    ..to explore its use in various disorders like tumors of skin, colon, duodenum, pancreas, breast and other skin diseases. This chapter reviews the data on the use of curcumin for the chemoprevention and treatment of various skin ..
  49. ncbi Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases
    Karsten Konig
    JenLab GmbH, Schillerstrasse 1, 07745 Jena, Germany
    J Biophotonics 2:389-97. 2009
    ..47 patients with a variety of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and ..
  50. ncbi Mobile teledermatology in the developing world: implications of a feasibility study on 30 Egyptian patients with common skin diseases
    Kathleen Tran
    Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Am Acad Dermatol 64:302-9. 2011
    ....
  51. ncbi An IFN-associated cytotoxic cellular immune response against viral, self-, or tumor antigens is a common pathogenetic feature in "interface dermatitis"
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Invest Dermatol 128:2392-402. 2008
    ....
  52. pmc Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice
    Heidi Koegel
    Institute of Cell Biology, Department of Biology, ETH Zurich, Zurich, Switzerland
    J Clin Invest 119:899-910. 2009
    ..These results reveal that loss of SRF disrupts epidermal homeostasis and strongly suggest its involvement in the pathogenesis of hyperproliferative skin diseases, including psoriasis.
  53. ncbi The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure
    Anna Lena Lindberg
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Toxicol Appl Pharmacol 230:9-16. 2008
    ..Thus, it can be speculated that this is due to a programming effect of arsenic in utero...
  54. pmc Ozone and ozonated oils in skin diseases: a review
    V Travagli
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Viale Aldo Moro 2, 53100 Siena, Italy
    Mediators Inflamm 2010:610418. 2010
    ....
  55. ncbi Chemotherapy-induced dermatological toxicity: frequencies and impact on quality of life in women's cancers. Results of a prospective study
    Mark Hackbarth
    Department of Gynecology and Obstetrics, Charite, Campus Virchow Klinikum, University Hospital, Berlin, Germany
    Support Care Cancer 16:267-73. 2008
    ..The study aimed to determine the prevalence of dermatological side effects and its impact on quality of life in patients receiving systemic chemotherapy for women's cancers...
  56. ncbi Psychosomatic assessment of skin diseases in clinical practice
    Angelo Picardi
    Dermatological Institute IDI IRCCS, Rome, Italy
    Psychother Psychosom 74:315-22. 2005
    ..was to provide a systematic psychosocial evaluation of a large and heterogeneous population of patients with skin diseases, including assessments of quality of life, psychiatric status according to the DSM-IV and psychological ..
  57. ncbi Learning more from microarrays: insights from modules and networks
    David J Wong
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Invest Dermatol 125:175-82. 2005
    ....
  58. ncbi Cytogenetic damage and genetic variants in the individuals susceptible to arsenic-induced cancer through drinking water
    Pritha Ghosh
    Indian Institute of Chemical Biology, Kolkata, and West Bank Hospital, Howrah, India
    Int J Cancer 118:2470-8. 2006
    ..24-2.22). These results show a protective role of GSTM1 null in arsenic toxicity. This study also indicates that asymptomatic individuals are sub clinically affected and are also significantly susceptible to arsenic-induced genotoxicity...
  59. ncbi A review of 55 cases of cutaneous lymphoid hyperplasia: reassessment of the histopathologic findings leading to reclassification of 4 lesions as cutaneous marginal zone lymphoma and 19 as pseudolymphomatous folliculitis
    Eiichi Arai
    Department of Pathology, Saitama Medical School, Iruma gun, Japan
    Hum Pathol 36:505-11. 2005
    ..Pseudolymphomatous folliculitis was identified by the presence of activated pilosebaceous units with abundant CD1a-and S-100 protein-positive T-cell-activated dendritic cells. Of the cases that were reassessed, 34.5% were PLF...
  60. ncbi Merkel cell polyomavirus DNA detection in lesional and nonlesional skin from patients with Merkel cell carcinoma or other skin diseases
    V Foulongne
    Laboratory of Virology, Department of Biology and Pathology, University of Montpellier I, 34295 Montpellier, France
    Br J Dermatol 162:59-63. 2010
    ..Results MCPyV DNA was detected in 14 of 18 (78%) patients with MCC, five of 18 (28%) patients with other skin diseases (P = 0.007) and one of six (17%) clinically healthy subjects...
  61. ncbi Dermatologic lesions in asymptomatic blood donors seropositive for human T cell lymphotropic virus type-1
    Denise Utsch Gonçalves
    Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Am J Trop Med Hyg 68:562-5. 2003
    ..77, 95% confidence interval [CI] = 4.11-18.71). The most common skin diseases were dermatophytoses (adjusted OR = 3.32, 95% CI = 1.50-7.35), seborrheic dermatitis (OR = 3.53, 95% CI = 0...
  62. ncbi Topical treatment with povidone iodine reduces nitrogen mustard-induced skin collagenolytic activity
    Uri Wormser
    Faculty of Sciences, Berman Building, The Hebrew University, Edmond Safra Campus, Givat Ram, 91904 Jerusalem, Israel
    Arch Toxicol 76:119-21. 2002
    ..Reduced collagenolytic activity may serve as one of the mechanisms by which iodine protects the skin against chemical insult...
  63. ncbi Rectal and cutaneous malakoplakia in an orthotopic cardiac transplant recipient
    J C Teeters
    Department of Cardiology, University of Rochester Medical Center, Rochester, New York 14609, USA
    J Heart Lung Transplant 26:411-3. 2007
    ..We review the current perspectives on the pathophysiology, diagnosis and treatment of this disease...
  64. ncbi Role of soluble and cell surface molecules in the pathogenesis of autoimmune skin diseases
    M Drosera
    Di S E M Section of Dermatology, University of Genoa, Genoa, Italy
    Clin Exp Rheumatol 24:S7-13. 2006
    ..Data regarding the activity of DNAse in patients with cutaneous lupus erythematosus as a possible risk factor for the development of systemic disease are here reported...
  65. ncbi The prevalence of skin diseases in the elderly: analysis of 4099 geriatric patients
    Basak Yalcin
    Ankara Numune Education and Research Hospital, Dermatology Department, and Hacettepe University Institute of Oncology, Ankara, Turkey
    Int J Dermatol 45:672-6. 2006
    ..The geriatric population is composed of persons over 65 years of age, and few studies are available on the dermatologic diseases in this group...
  66. ncbi The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology
    David R Bickers
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, USA
    J Am Acad Dermatol 55:490-500. 2006
    ..2 billion dollars. Including the economic burden on quality of life, the total economic burden of skin disease to the US public in 2004 was approximately 96 billion dollars...
  67. ncbi Pruritus and hydration state of stratum corneum in hemodialysis patients
    A Kato
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Nephrol 20:437-42. 2000
    ..Since the skin surface hygrometer can detect the changes of water content in the stratum corneum more sensitively, we re-examined the relationship between the severity of pruritus and water content in dialysis patients...
  68. ncbi Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases
    Hidehisa Saeki
    Department of Dermatology, Graduate School of Medicine, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 43:75-84. 2006
    ..TARC is designated a Th2 type chemokine since it binds to CCR4. We review the pathogenic role of TARC in skin diseases such as atopic dermatitis (AD), bullous pemphigoid (BP) and mycosis fungoides (MF) focusing on epidermal KC ..
  69. ncbi A case of persistent subepidermal calcified nodule in an adult treated with CO2 laser
    Young Hyun Joo
    Department of Dermatology, Seoul National University College of Medicine, Seoul, and Seoul National University Bundang Hospital, Gyeonggi, Korea
    J Dermatol 31:480-3. 2004
    ..The treatment of choice is believed to be surgical excision. We describe a case of SCN on the right ear lobe of a 33-year-old male, which was treated using a CO2 laser and electrodessication...
  70. pmc Keratinocyte apoptosis in epidermal development and disease
    Deepak Raj
    Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
    J Invest Dermatol 126:243-57. 2006
    ..Dysfunctional apoptosis occurs in some skin diseases, such as psoriasis and skin cancer...
  71. ncbi Insights into the pathophysiology and management of dermatologic toxicities to EGFR-targeted therapies in colorectal cancer
    Mario E Lacouture
    Cancer Skin Care Program and SERIES Clinic, Department of Dermatology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Ill 60611 2941, USA
    Cancer Nurs 30:S17-26. 2007
    ..Effective management of these adverse effects may lessen the chance of suboptimal therapy and requires an understanding of the underlying pathophysiology, as well as knowledge of useful strategies for alleviating these effects...
  72. ncbi In vitro antimicrobial activity of certain medicinal plants from eastern Ghats, India, used for skin diseases
    A Jeevan Ram
    Department of Botany, Sri Krishnadevaraya University, Anantapur 515003, India
    J Ethnopharmacol 90:353-7. 2004
    ..Ethanolic extracts of 23 crude drug samples used for various skin diseases were assayed for antimicrobial activity against four bacterial and one fungal human pathogens.
  73. ncbi Recalcitrant cutaneous sarcoidosis responding to infliximab
    Michael P Heffernan
    Arch Dermatol 141:910-1. 2005
  74. ncbi Sarcoidosis
    Michael C Iannuzzi
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Mount Sinai School of Medicine, New York, USA
    N Engl J Med 357:2153-65. 2007
  75. ncbi Cellular genomic maps help dissect pathology in human skin disease
    Asifa S Haider
    Laboratory of Investigative Dermatology, The Rockefeller University, New York, New York 10021 6399, USA
    J Invest Dermatol 128:606-15. 2008
    ..We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps...
  76. pmc Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response
    Ali R Djalilian
    National Human Genome Research Institute, National Eye Institute, and National Institute of Child Health and Development, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1243-53. 2006
    ..More generally, these studies suggest that the most effective treatments for inflammatory skin disorders might concomitantly suppress the immune response and enhance epidermal differentiation to restore the barrier...
  77. ncbi Hyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects
    G Weindl
    Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany
    Skin Pharmacol Physiol 17:207-13. 2004
    ..Increased HA concentrations have been associated with inflammatory skin diseases. In clinical trials, topical application of HA improved wound healing; in particular, acute radioepithelitis, ..
  78. ncbi Cutaneous side-effects in patients on long-term treatment with epidermal growth factor receptor inhibitors
    A Osio
    Department of Dermatology, Institute Gustave Roussy, Villejuif, France
    Br J Dermatol 161:515-21. 2009
    ..Much less is known about the chronic cutaneous effects of these drugs and about their potential psychosocial impact on patients...
  79. ncbi Oxidative stress in the pathogenesis of skin disease
    David R Bickers
    Department of Dermatology, Columbia University Medical Center, New York, New York, USA
    J Invest Dermatol 126:2565-75. 2006
    ..Although many antioxidants have shown substantive efficacy in cell culture systems and in animal models of oxidant injury, unequivocal confirmation of their beneficial effects in human populations has proven elusive...
  80. ncbi Acute and chronic effects of sulfur mustard on the skin: a comprehensive review
    Mostafa Ghanei
    Research Center of Chemical Injuries, Baqiyatallah University of Medical Sciences, Mollasadra St, Tehran, Iran
    Cutan Ocul Toxicol 29:269-77. 2010
    ..The aim of this article is to review the acute and long-term cutaneous findings resulting from SM exposure. Also, cellular and molecular mechanism involved in SM-induced skin pathology have been discussed...
  81. ncbi Gadolinium is detectable within the tissue of patients with nephrogenic systemic fibrosis
    Whitney A High
    Department of Dermatology, University of Colorado Health Sciences Center, Denver, USA
    J Am Acad Dermatol 56:21-6. 2007
    ..We sought to detect gadolinium within the skin and soft tissue of patients with NSF who were exposed to gadolinium-based contrast...
  82. ncbi Decorative cosmetics improve the quality of life in patients with disfiguring skin diseases
    Wolf Henning Boehncke
    Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590, Frankfurt Main, Germany
    Eur J Dermatol 12:577-80. 2002
    ..Twenty female patients (16-69 y) with skin diseases affecting the patients' face (acne, n = 8; rosacea, n = 9; chronic discoid lupus erythematodes, n = 2; ..
  83. ncbi Innovative use of topical calcineurin inhibitors
    Andrew N Lin
    Division of Dermatology and Cutaneous Sciences, University of Alberta, 2 104 Clinical Sciences Building, Edmonton, Alberta, T6G 2G3, Canada
    Dermatol Clin 28:535-45. 2010
    ..Topical calcineurin inhibitors have been effective in many other cutaneous disorders, and further studies would help clarify their roles...
  84. ncbi Chemokine networks in inflammatory skin diseases
    Saveria Pastore
    Istituto Dermopatico dell Immacolata, IRCCS, Via Monti di Creta 104, 00167 Roma, Italy
    Eur J Dermatol 14:203-8. 2004
    ..and promiscuous, and forms a complex network relevantly involved in the expression of chronic inflammatory skin diseases, including allergic contact dermatitis, atopic dermatitis and psoriasis...
  85. ncbi AGE-modified collagens I and III induce keratinocyte terminal differentiation through AGE receptor CD36: epidermal-dermal interaction in acquired perforating dermatosis
    Eita Fujimoto
    Department of Dermatology, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Invest Dermatol 130:405-14. 2010
    ....
  86. ncbi Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh
    Habibul Ahsan
    Departments of Epidemiology, Columbia University, USA
    Cancer Epidemiol Biomarkers Prev 16:1270-8. 2007
    ....
  87. pmc EKV mutant connexin 31 associated cell death is mediated by ER stress
    Daniel Tattersall
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Hum Mol Genet 18:4734-45. 2009
    ..These results indicate that, in vivo, ER stress may lead to abnormal keratinocyte differentiation and hyperproliferation in EKV patient skin...
  88. ncbi Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and management
    Jenny C Hu
    David Geffen School of Medicine at University of California, Los Angeles 90095, USA
    J Am Acad Dermatol 56:317-26. 2007
    ..With effective management of these side effects, dermatologists can play an integral role in facilitating compliance with anti-EGFR therapy and aid with effective oncologic management...
  89. ncbi Efficacy and skin toxicity management with cetuximab in metastatic colorectal cancer: outcomes from an oncologic/dermatologic cooperation
    Patrizia Racca
    Centro Universitario di Ricerca Oncologica, Oncologia Medica I, ASO San Giovanni Battista Ospedale Molinette, Torino, Italy
    Clin Colorectal Cancer 7:48-54. 2008
    ..The aim of this study was to investigate the efficacy of the combination of irinotecan/cetuximab and to plan related skin toxicity management with an oncologic/dermatologic team...
  90. ncbi The mystery of Morgellons disease: infection or delusion?
    Virginia R Savely
    South Austin Family Practice Clinic, Austin, Texas, USA
    Am J Clin Dermatol 7:1-5. 2006
    ..Further clinical and molecular research is needed to unlock the mystery of Morgellons disease...
  91. ncbi Cutaneous manifestations of internal malignancy
    Bruce H Thiers
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC, USA
    CA Cancer J Clin 59:73-98. 2009
    ....
  92. ncbi Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review
    Takahiko Yoshida
    Department of Health Science, Asahikawa Medical College, Asahikawa, Hokkaido 078 8510, Japan
    Toxicol Appl Pharmacol 198:243-52. 2004
    ....
  93. ncbi Nephrogenic fibrosing dermopathy with systemic involvement
    William W Ting
    Department of Dermatology, University of Iowa College of Medicine, Iowa City, USA
    Arch Dermatol 139:903-6. 2003
    ..Soft tissue calcification is rare in patients with NFD and systemic involvement has not been reported...
  94. ncbi Immunopathogenesis of sarcoidosis
    Aliya Noor
    Division of Pulmonary and Critical Care Medicine, Indiana University and the Richard L Roudebush VA Medical Center, Indianapolis, IN
    Clin Dermatol 25:250-8. 2007
    ....
  95. ncbi Lipid nanoparticles for improved topical application of drugs for skin diseases
    Monika Schäfer-Korting
    Institut fur Pharmazie, Pharmakologie und Toxikologie, der Freien Universität Berlin, D 14195 Berlin, Germany
    Adv Drug Deliv Rev 59:427-43. 2007
    ..A special focus is upon the interactions of active ingredients and the lipid matrix as well as the quantification of dermal penetration...
  96. ncbi Dialysis-associated systemic fibrosis (nephrogenic fibrosing dermopathy): study of inflammatory cells and transforming growth factor beta1 expression in affected skin
    Sergio A Jimenez
    Division of Rheumatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541, USA
    Arthritis Rheum 50:2660-6. 2004
    ..The aim of the present study was to describe the clinical and histopathologic features of 9 new cases and to characterize the inflammatory cells and expression of transforming growth factor beta1 (TGFbeta1) in affected skin...
  97. ncbi Prevalence of skin diseases at a healthcare clinic in a small Brazilian town
    Tatiana Federige Oliveira
    Asas de Socorro, Belem, PA, Brazil
    An Bras Dermatol 85:947-9. 2010
    Doctors who are not specialists in dermatology often have difficulty diagnosing and managing prevalent skin diseases. The objective of this study was to evaluate the prevalence of skin diseases during a three-day healthcare clinic ..
  98. ncbi The effects of alcohol and drug abuse on the skin
    Stephanie W Liu
    Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, MDC 79, Tampa, FL 33612, USA
    Clin Dermatol 28:391-9. 2010
    ....
  99. ncbi Long-term skin damage due to chemical weapon exposure
    Alireza Firooz
    Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
    Cutan Ocul Toxicol 30:64-8. 2011
    ..Skin xerosis and pruritus, pigmentation disorders, scars, and cherry angiomas are among the most common long-term skin lesions after contact with SM. Although SM is a well-known carcinogenic substance, skin cancers are rarely reported...
  100. ncbi Clinical role and application of superficial chemical peels in today's practice
    Diane S Berson
    New York Presbyterian Hospital, New York, NY, USA
    J Drugs Dermatol 8:803-11. 2009
    ..Used properly, the superficial chemical peel has the potential to fill an important therapeutic need in the treatment armamentarium of dermatologists and plastic surgeons...
  101. ncbi Cutaneous amyloidosis: a concept review
    Angel Fernandez-Flores
    Department of Pathology, Hospital El Bierzo, Ponferrada, Spain
    Am J Dermatopathol 34:1-14; quiz 15-7. 2012
    ..We present a review, from Virchow to present, of the concepts related to amyloidosis: its nature, the classification of cutaneous forms of the disease, and the techniques used in its diagnosis...

Research Grants69

  1. Targeting p53-Dependent Repigmentation in Vitiligo
    TAMARA G TERZIAN; Fiscal Year: 2013
    ..of the Dermatology Department at UCD and the director of the Training Grant in Immunodermatology and the UCD Skin Diseases Research Core Center (UCD-SDRC), both of which are funded by NIAMS. Dr...
  2. Testing the Therapeutic Potential of iPS Cells for Inherited Skin Diseases
    Jakub Tolar; Fiscal Year: 2013
    ..If the studies outlined in this application are successful, these pre-clinical data will pave the way for approval of iPSC-based clinical trials for not only other forms of EB, but also other inherited skin disorders. ..
  3. Characterization of IL36, a novel cytokine
    Albert Zlotnik; Fiscal Year: 2012
    ..In Specific Aim 3, we will study the possible role of IL36 in human skin diseases, by studying its expression in archived skin samples from patients with various diseases...
  4. Cicatricial Alopecia Research Symposium 2011: Lipids, Inflammation &Stem Cells
    Pratima Karnik; Fiscal Year: 2011
    ..a common goal - understanding and eventually finding a cure for cicatricial alopecia and other inflammatory skin diseases. The specific goals of this proposal are to generate funds to support Young Investigator Awards, and the ..
  5. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ..This may lead to novel therapeutic strategies to combat skin diseases that have a neuronal component, like atopic dermatitis and other eczemas, or rosacea, and to reduce the ..
  6. Roles of Hox genes in skin and hair follicle development
    Alexander Awgulewitsch; Fiscal Year: 2010
    ..any or all of these genes result in a various types of alopecia, many of which are identical to specific human skin diseases. Our goal is to determine how these genes interact with each other, which will ultimately define how these ..
  7. Delivery of biologically active nucleic acids to epidermal cells
    ROGER L contact KASPAR; Fiscal Year: 2010
    ..It is not hard to imagine well over 350 distinct nucleic acid drugs designed to treat specific skin diseases. Yet, apart from use in vaccines, no nucleic acids are approved for use in human skin...
  8. Keratin Biology and Disease Aspects in Simple Epithelia
    Bishr Omary; Fiscal Year: 2013
    ..For example, several skin diseases are caused by mutations in epidermal keratins, and K8 and K18 mutations predispose to liver disease and its ..
  9. Protein Therapy for Recessive Dystrophic Epidermolysis Bullosa
    David T Woodley; Fiscal Year: 2010
    ..our proposed study could provide the proof of principle for using protein therapy for other intractable skin diseases due to genetic defects in skin structural proteins...
  10. Keratinocyte regulation of skin immunity
    Anthony A Gaspari; Fiscal Year: 2013
    ..Relevance to the VA: Contact dermatitis a very common inflammatory skin diseases in the industrialized world. It is a major health concern for patients and has a major impact on the economy...
  11. Characterization of Enhancers in the Epidermal Differentiation Complex
    CRISTINA DE GUZMAN STRONG; Fiscal Year: 2012
    Atopic dermatitis (AD) and psoriasis are two inflammatory skin diseases that affect over 22.5 million Americans collectively and are burdening the U.S. economy with over $7.5 billion dollars in management and quality-of-life issue costs...
  12. Syk blockade in bullous skin diseases
    Uma Sinha; Fiscal Year: 2012
    ..involving Portola and the leaders in their respective fields in Syk/Fc receptor biology (Columbia) and bullous skin diseases (Lubeck) to overcome the barriers to translation in this orphan skin disease...
  13. Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation,
    ARUP K INDRA; Fiscal Year: 2012
    ..g., transcription factors) in skin is the key for the development of effective treatments for the various skin diseases described above, as well as epithelial cell skin cancers, including head and neck squamous cell carcinoma (..
  14. The Role of IgE in Autoimmune Skin Diseases
    Janet A Fairley; Fiscal Year: 2013
    ..Understanding the role of IgE autoantibodies in BP will provide insight into the role of IgE in immunologic reactions and lead to new areas for therapeutic intervention. ..
  15. Mechanisms used by skin dendritic cells to induce regulatory T cells
    Juliana Idoyaga; Fiscal Year: 2013
    ..Also, this knowledge is likely to be beneficial to the development new therapeutic targets to increase T reg, which in turn will lead to improved treatment of inflammatory skin diseases and their complications.
  16. Protein Kinase D and Epidermal Structure and Function
    Wendy B Bollag; Fiscal Year: 2010
    ..Thus, these results suggest a link between sun exposure/ultraviolet light, PKD levels/activation and human skin diseases, such as BCC...
  17. Aging Stratum Corneum pH and Barrier Function
    Theodora M Mauro; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aged skin commonly is afflicted by inflammatory skin diseases or xerosis/eczema that can be traced to, or exacerbated by, impaired epidermal permeability barrier homeostasis...
  18. Mechanism of skin-specific targeting of adult stem cells
    Olga Igoucheva; Fiscal Year: 2013
    ..in various genes essential for normal functioning of the skin and represent most challenging and intractable skin diseases with no clinically applicable therapies available...
  19. Regulation of human skin homeostasis by histone arginine methylation regulators
    Xiaomin Bao; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Epidermal homeostasis is disrupted in a host of human skin diseases, including psoriasis, chronic wounds, and cancer...
  20. Role of Beta 1 containing Integrins in Cutaneous Basement Membrane Organization
    Srikala Raghavan; Fiscal Year: 2010
    ..Loss of basement membrane integrity is associated with devastating skin diseases and metastatic skin cancers...
  21. Biological Markers of System Burden in Symptomatic Knee OA: A Prospective Study
    KIMBERLY THERESA SIBILLE; Fiscal Year: 2013
    ..Additionally, the proposed research aligns with the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Long Range Plan for Fiscal Years 2010-2014 and the 2010 NIAMS Roundtable Summary...
  22. Comparative Effectiveness of Biologics for Psoriasis
    Joel M Gelfand; Fiscal Year: 2010
    ..Effectiveness Research, 05-AR-101 Comparative Effectiveness (CE) of Biologics in Autoimmune Rheumatic and Skin Diseases Title of application: Comparative Effectiveness of Biologics for Psoriasis Psoriasis is a chronic, ..
  23. Transforming Growth Factor-Beta (TGF-b) Signaling in Aged Skin
    Taihao Quan; Fiscal Year: 2013
    ..structural integrity of skin connective tissue, and thereby impairing skin function and promoting age-related skin diseases. Our findings from the initial grant demonstrate that age-related reduction of type I collagen is mediated by ..
  24. Epha/Ephrin - A Signaling in Epidermal Differentiation and Disease
    Spiro Getsios; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Epidermal differentiation is essential for survival and impaired in common skin diseases, including psoriasis...
  25. Role of FATP4 in Skin Development
    Jeffrey H Miner; Fiscal Year: 2012
    ..A number of human genetic skin diseases have been shown to stem from defects in genes that encode proteins involved in lipid trafficking...
  26. Molecular Pathology of HIV/SIV Enteropathy
    Mahesh Mohan; Fiscal Year: 2013
    ..extensively in various types of cancer, and at increasing rates in cardiac, neurological, metabolic and skin diseases, their role in idiopathic GI disorders such as HIV/SIV enteropathy is unknown and yet to be addressed...
  27. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas S Kupper; Fiscal Year: 2012
    ..immunization, and how memory T cells enter and exit skin, is critical for developing better treatments for skin diseases. It is also critical for development and optimization of vaccines, the majority of which are given via skin ..
  28. Origin and Function of Inflammatory Dendritic Cells in Psoriasis.
    Michelle A Lowes; Fiscal Year: 2013
    ..The current approach to treating skin diseases with a critical pathogenic T cell component, is to use broad T cell-targeted immunosuppressive therapies...
  29. Cyclic nucleotide permeability of connexin mutants related to genetic disease
    Virginijus Valiunas; Fiscal Year: 2013
    ..been implicated in many hereditary diseases, including nervous system disorders, deafness, cataracts and some skin diseases. Mutations in connexin43 (Cx43) have been linked to oculodentodigital dysplasia (ODDD) which manifests with ..
  30. ETIOLOGY AND PATHOGENESIS OF PEMPHIGUS
    Luis A Diaz; Fiscal Year: 2013
    ..might trigger, in certain genetically predisposed individuals, an autoimmune IgG4 response that leads to skin diseases. In parallel, new epitope-specific immunoassays and potential novel therapeutic interventions may evolve from ..
  31. Functional Analysis of the Hairless Protein
    Angela M Christiano; Fiscal Year: 2012
    ..hairless regulates cell growth and proliferation in the epidermis, both in the normal setting, and in certain skin diseases. These findings may prove useful for gaining understanding a number of different skin disorders where ..
  32. Gene Transfer for Recessive Dystrophic Epidermolysis Bullosa
    MATT PETER MARINKOVICH; Fiscal Year: 2013
    ..This application fulfills the mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases through focused research upon treatment of this severe skin disease by translational application of previous ..
  33. Cx26 mutations in syndromic deafness linked to skin disease
    Thomas W White; Fiscal Year: 2013
    ..The Cx26 mutations causing skin diseases and deafness are all single amino acid changes, and the mechanism(s) whereby they lead to skin pathology are ..
  34. Mineralization Gene Variants: Biochemical Implications and Associations with BMD
    Carrie M Nielson; Fiscal Year: 2013
    ..Mentored Research Scientist Development Award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) to facilitate my progression to an independent investigator in the genetics of osteoporosis...
  35. Keratin Gene Targeting for the Treatment of Epidermolysis Bullosa
    Daniel G Miller; Fiscal Year: 2013
    ..and serve as a foundation for future studies that may lead to clinical trials for a variety of debilitating skin diseases. PUBLIC HEALTH RELEVANCE: Epidermolysis Bullosa Simplex (EBS) is an extremely debilitating disease ..
  36. Role of c-Jun N-terminal kinases in human epidermal homeostasis.
    PAULA MILIANIDEMARVAL; Fiscal Year: 2010
    ..b:This proposal aims to investigate the functional mechanisms of JNK-MAPKs in epidermal homeostasis. It is relevant to human skin diseases associated with abnormal cell growth and differentiation including cancer.
  37. Transcriptional Co-Regulatiors in Epidermis
    Bogi Andersen; Fiscal Year: 2013
    ..Altered keratinocyte differentiation and a defective epidermal barrier are prominent contributors to multiple skin diseases including ichthyoses, inflammatory skin diseases, skin cancer and wound healing defects...
  38. Short Wavelength UV Sources for Treatment of Psoriasis
    JOSEPH SMART; Fiscal Year: 2006
    ..wavelength range will enable research for new phototherapy treatment programs for psoriasis and possibly other skin diseases including acne vularis, atopic dermatitis, vitiligo, pruritus, lichen planus, pityriasis rosea and early ..
  39. Planar Cell Polarity Signaling in Hair Follicle Formation
    Jiang Chen; Fiscal Year: 2013
    ..pathway during hair follicle formation, and may provide new insights into the development of hair and other skin diseases such as alopecia and BCC, based on which novel treatment strategies for these skin conditions may be developed. ..
  40. Mechanisms of Altered Skin Re-Epithelialization in Aging
    Laure Rittie; Fiscal Year: 2013
    ..Given that "activation" keratin overexpression is also a hallmark of multiple hyperproliferative skin diseases, genetic conditions, and epithelial cancers, our results are expected to be directly applicable to many ..
  41. MPZL3, a novel putative adhesion protein, in keratinocyte stem cell maintenance
    Tongyu Cao Wikramanayake; Fiscal Year: 2012
    ..the role of MPZL3 in epidermal differentiation and function, and how dysregulation of MPZL3 may be involved in skin diseases. We hypothesize that MPZL3 functions as a cell adhesion protein important for maintaining the SC population in ..
  42. Mechanisms of sensory neuron control over skin immune responses
    JOSE MANUEL ORDOVAS-MONTANES; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psoriasis and other pathological skin diseases have typically been considered as immune-driven diseases...
  43. Interferons and cytotoxic lymphocytes in dermatomyositis and cutaneous lupus
    DAVID FRANKLIN FIORENTINO; Fiscal Year: 2013
    ..patients in vivo, thereby facilitating diagnosis, prediction nd monitoring of clinical course in autoimmune skin diseases. The studies will address whether disease subsets defined using these markers respond differently to newly ..
  44. Function of Desmoglein 1/Pemphigus Foliaceus Antigen
    KATHLEEN JANEE GREEN; Fiscal Year: 2013
    ..cytoarchitectural scaffolds choreograph chemical signaling to promote differentiation will be essential for treating skin diseases where these pathways are undermined through cadherin gene defects, autoantibodies or bacterial pathogens.
  45. Novel Biosynthethic Pathway for Secosteroids and the Skin
    Andrzej T Slominski; Fiscal Year: 2013
    ..The novel secosteroids can serve as therapeutic agents for proliferative, fibrosing and other skin diseases, because of their high biological potency [similar to 1,25(OH)2D3] without identifiable toxic effects...
  46. Keratinocyte Activation by Slug-induced Calprotectin
    Donna F Kusewitt; Fiscal Year: 2013
    ..It may be possible to take advantage of the interaction between Slug and calprotectin to design new strategies to prevent and treat a wide spectrum of skin diseases.
  47. The Peripheral and Central Neuronal Circuits that Underlie Itch
    Hyosang Lee; Fiscal Year: 2012
    ..by applicant): Itch, one the most distressing of dermatological symptoms, is associated with numerous skin diseases, such as atopic dermatitis, as well as with extracutaneous disorders...
  48. Vitamin D Ligands and Regulation of Calcium Homeostasis
    J Wesley Pike; Fiscal Year: 2012
    ..synthetic derivatives thereof may be useful therapeutically for such indications as cancer, and autoimmune and skin diseases. This utility is plagued, however, by the propensity for 1,25(OH)2D3 to hyper-induce intestinal calcium ..
  49. Characterization of Homeostatic Regulators Disrupted in Epidermal Neoplasia
    CAROLYN S LEE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Perturbations in epidermal homeostasis result in a wide variety of human skin diseases, including cancer...
  50. MicroRNA-mediated Regulation in Mammalian Skin
    Rui Yi; Fiscal Year: 2013
    ..developmental transitions during mammalian skin morphogenesis as well as their potential involvement in human skin diseases have attracted significant interests in the role of these novel regulators in skin biology...
  51. Proteolysis and Skin Antimicrobials
    Richard L Gallo; Fiscal Year: 2013
    ..Control of this processing is relevant to skin diseases ie. rosacea and psoriasis...
  52. Targeting IFN gamma and chemokines to treat vitiligo in a humanized mouse model
    John E Harris; Fiscal Year: 2013
    ..that this humanized mouse will provide a functional immune-skin axis in which potential new therapies for skin diseases can be tested prior to clinical studies...
  53. A Novel Class of Therapeutic Agents for the Treatment of Skin Diseases Associated
    Joel S Gordon; Fiscal Year: 2010
    ..can identify more potent and selective 2nd generation IPC compounds to effectively treat chronic inflammatory skin diseases associated with erythema...
  54. Role of Noncoding RNAs in Epidermal Differentiation
    BRYAN SUN; Fiscal Year: 2012
    ..Dysregulated skin differentiation is a hallmark of several skin diseases, and improving the knowledge of the molecular regulators of the differentiation process will facilitate ..
  55. Hyaluronan in Epidermal Injury Responses
    Edward Maytin; Fiscal Year: 2009
    ..Findings from the research could provide new approaches for dampening epidermal hyperplasia and reducing abnormal cornification, thus providing new opportunities to ameliorate several very common skin diseases.
  56. Support Services for Two National Information Clearinghouses
    KIMBERLY HOLMES; Fiscal Year: 2011
    To provide support to the National Institute of Arthritis and Musculoskeletal and Skin Diseases'(NIAMS) comprehensive program of information dissemination to patients, their health care providers, the research community, and the ..
  57. 2010 Ligand Recognition and Molecular Gating Gordon Research Conference
    NANCY RYAN GRAY; Fiscal Year: 2010
    ..vision/ depression/cardiovascular diseases (G-protein coupled receptors), neurodegenerative diseases, skin diseases, deafness, and developmental abnormalities (connexins) to neurological diseases (ion channels)...
  58. IGF::OT::IGF SUPPORT SERVICES FOR TWO INFORMATION CLEARINGHOUSES, NIAMS, NIH
    Kim Holmes; Fiscal Year: 2013
    To provide support to the National Institute of Arthritis and Musculoskeletal and Skin Diseases'(NIAMS) comprehensive program of information dissemination to patients, their health care providers, the research community, and the ..
  59. Support Services for Two National Information Clearinghouses
    JENNIFER BLACKER; Fiscal Year: 2010
    To provide support to the National Institute of Arthritis and Musculoskeletal and Skin Diseases'(NIAMS) comprehensive program of information dissemination to patients, their health care providers, the research community, and the ..
  60. Support Services for Two National Information Clearinghouses
    KIMBERLY HOLMES; Fiscal Year: 2012
    To provide support to the National Institute of Arthritis and Musculoskeletal and Skin Diseases'(NIAMS) comprehensive program of information dissemination to patients, their health care providers, the research community, and the ..
  61. The role of microRNA miR-31 in skin biology
    Thomas Andl; Fiscal Year: 2013
    ..In our proposal we will focus on one microRNA, miR-31, with an exceptional expression pattern in many skin diseases. This finding prompted us to address the functional significance of miR-31 in epidermal homeostasis, aberrant ..
  62. Training for Investigative Dermatology
    JOHN EVERETT OLERUD; Fiscal Year: 2013
    See instructions): The Burden of Skin Diseases 2005 (available at http://www.sidnet...
  63. Development of Topical Neuroinflammatory Inhibitors
    MANDIP SACHDEVA; Fiscal Year: 2005
    ..Certain skin diseases such as psoriasis, contact dermatitis and atopic dermatitis may have a significant neurogenic component...
  64. SEROLOGICAL EXPRESSION ANALYSIS OF VITILIGO AND ALOPECIA
    Vijayasaradhi Setaluri; Fiscal Year: 2001
    ..from the application): Autoimmune reactions to components of skin and its appendages produce a spectrum of skin diseases. Vitiligo, characterized by partial or complete loss of skin pigmentation and alopecia areata, a chronic ..
  65. MACROPHAGE/NEUTROPHIL ELASTASE INHIBITOR
    EILEEN REMOLD O DONNELL; Fiscal Year: 1999
    ..bronchiectasis, asthma, chronic bronchitis, sarcoidosis, respiratory distress syndrome, arthritis and some skin diseases. We have characterized, isolated and cloned a fast acting inhibitor of neutrophil elastase called "Human ..
  66. Clinical and Cost-effectiveness of biologics in Rheumatoid Arthritis
    Hyon K Choi; Fiscal Year: 2010
    ..05) and specific Challenge Topic of Comparative Effectiveness of Biologics in Autoimmune Rheumatic and Skin Diseases (05-AR-101)...
  67. Polymer Web Sensing System
    LEONID BUKSHPUN; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Skin diseases resulting from occupational accidents are the most common non-trauma-related occupational illness...
  68. MECHANISMS OF COLLAGEN ACCUMULATION IN DERMAL FIBROSES
    Jouni Uitto; Fiscal Year: 1990
    ..The studies will utilize skin fibroblast cultures established from patients with fibrotic skin diseases, and will specifically focus on two clinical conditions, keloids and progressive systemic sclerosis, which ..
  69. Kaiser Permanente Autoimmune Disease Registry
    Lisa J Herrinton; Fiscal Year: 2010
    ..and specific Challenge Topic 05-AR-101: Comparative Effectiveness of Biologics in Autoimmune Rheumatic and Skin Diseases, with emphasis on five diseases: rheumatoid arthritis (RA), juvenile inflammatory arthritis (JIA), psoriatic ..