systemic lupus erythematosus

Summary

Summary: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Top Publications

  1. doi Systemic lupus erythematosus
    Anisur Rahman
    Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom
    N Engl J Med 358:929-39. 2008
  2. pmc Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nat Genet 40:1059-61. 2008
  3. ncbi Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    Jane Tian
    Inflammation and Autoimmune Group, Research Department, MedImmune, Gaithersburg, Maryland 20878, USA
    Nat Immunol 8:487-96. 2007
  4. pmc Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
    Biola M Javierre
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona 08907, Spain
    Genome Res 20:170-9. 2010
  5. ncbi Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    Melissa R Arbuckle
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    N Engl J Med 349:1526-33. 2003
  6. pmc A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    Damien Chaussabel
    Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:150-64. 2008
  7. ncbi CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
    Paul A Blair
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T4 JF, UK
    Immunity 32:129-40. 2010
  8. ncbi The classification of glomerulonephritis in systemic lupus erythematosus revisited
    Jan J Weening
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Am Soc Nephrol 15:241-50. 2004
  9. ncbi Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    Nicholas Simpson
    Australian National University, Canberra, ACT, Australia
    Arthritis Rheum 62:234-44. 2010
  10. ncbi Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial
    Joan T Merrill
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Arthritis Rheum 62:222-33. 2010

Detail Information

Publications351 found, 100 shown here

  1. doi Systemic lupus erythematosus
    Anisur Rahman
    Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom
    N Engl J Med 358:929-39. 2008
  2. pmc Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nat Genet 40:1059-61. 2008
    b>Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors...
  3. ncbi Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    Jane Tian
    Inflammation and Autoimmune Group, Research Department, MedImmune, Gaithersburg, Maryland 20878, USA
    Nat Immunol 8:487-96. 2007
    ..Our data demonstrate a mechanism by which HMGB1 and RAGE activate plasmacytoid dendritic cells and B cells in response to DNA and contribute to autoimmune pathogenesis...
  4. pmc Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
    Biola M Javierre
    Chromatin and Disease Group, Cancer Epigenetics and Biology Programme PEBC, Bellvitge Biomedical Research Institute IDIBELL, L Hospitalet de Llobregat, Barcelona 08907, Spain
    Genome Res 20:170-9. 2010
    ..We used a cohort of MZ twins discordant for three diseases whose clinical signs often overlap: systemic lupus erythematosus (SLE), rheumatoid arthritis, and dermatomyositis...
  5. ncbi Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    Melissa R Arbuckle
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    N Engl J Med 349:1526-33. 2003
    Although much is known about the natural history of systemic lupus erythematosus (SLE), the development of SLE autoantibodies before the diagnosis of the disease has not been extensively explored...
  6. pmc A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus
    Damien Chaussabel
    Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Baylor Institute for Immunology Research and Baylor Research Institute, Dallas, TX 75204, USA
    Immunity 29:150-64. 2008
    ..and the development of a multivariate transcriptional indicator of disease progression in patients with systemic lupus erythematosus. Thus, this work describes the implementation and application of a methodology designed to support ..
  7. ncbi CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients
    Paul A Blair
    Centre for Rheumatology Research, Department of Medicine, University College London, 46 Cleveland Street, London W1T4 JF, UK
    Immunity 32:129-40. 2010
    ..In addition, CD19(+)CD24(hi)CD38(hi) SLE B cells isolated from the peripheral blood of systemic lupus erythematosus (SLE) patients were refractory to further CD40 stimulation, produced less IL-10, and lacked the ..
  8. ncbi The classification of glomerulonephritis in systemic lupus erythematosus revisited
    Jan J Weening
    Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    J Am Soc Nephrol 15:241-50. 2004
    ..We hope that this revision, which evolved under the auspices of the International Society of Nephrology and the Renal Pathology Society, will contribute to further advancement of the WHO classification...
  9. ncbi Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    Nicholas Simpson
    Australian National University, Canberra, ACT, Australia
    Arthritis Rheum 62:234-44. 2010
    ..The purpose of this study was to examine the hypothesis that this pathway could account for a subset of patients with systemic lupus erythematosus (SLE).
  10. ncbi Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial
    Joan T Merrill
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Arthritis Rheum 62:222-33. 2010
    B cells are likely to contribute to the pathogenesis of systemic lupus erythematosus (SLE), and rituximab induces depletion of B cells...
  11. ncbi Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus
    Agnes Doreau
    Universite de Lyon, Institut Fédératif de Recherche 128, Lyon, France
    Nat Immunol 10:778-85. 2009
    ..and the potential involvement of IL-17 in B cell biology, we found that the serum of patients with systemic lupus erythematosus had higher concentrations of IL-17 than did the serum of healthy people and that IL-17 abundance ..
  12. ncbi Systemic lupus erythematosus disease activity index 2000
    Dafna D Gladman
    The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 29:288-91. 2002
    To describe the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), a modification of SLEDAI to reflect persistent, active disease in those descriptors that had previously only considered new or recurrent occurrences, ..
  13. ncbi Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Immunity 25:417-28. 2006
    Antibodies (Abs) to RNA- and DNA-containing autoantigens are characteristic of systemic lupus erythematosus (SLE)...
  14. ncbi Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    Prapaporn Pisitkun
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases NIAID, NIH, Rockville, MD 20852, USA
    Science 312:1669-72. 2006
    ..These results reveal high divergence in mouse Y chromosomes and represent a good example of gene copy number qualitatively altering a polygenic disease manifestation...
  15. ncbi Th17 and natural Treg cell population dynamics in systemic lupus erythematosus
    Ji Yang
    Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China
    Arthritis Rheum 60:1472-83. 2009
    To investigate the relative abundance and activities of Th17 cells and natural Treg cells in systemic lupus erythematosus (SLE).
  16. ncbi Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity
    Chun Kwok Wong
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Clin Immunol 127:385-93. 2008
    ..We investigated the immunopathological mechanisms for activation of Th17 cells of patients with systemic lupus erythematosus (SLE)...
  17. pmc FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
    Manuela Fanciulli
    Physiological Genomics and Medicine Group, UK Medical Research Council MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nat Genet 39:721-3. 2007
    ..Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic polyangiitis (P = 2...
  18. pmc Altered B cell receptor signaling in human systemic lupus erythematosus
    Scott A Jenks
    Department of Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Autoimmun Rev 8:209-13. 2009
    ..b>Systemic lupus erythematosus (SLE) is characterized by a loss of B cell tolerance and the production of anti-self antibodies...
  19. pmc Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus
    Wanling Yang
    Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
    PLoS Genet 6:e1000841. 2010
    b>Systemic lupus erythematosus is a complex and potentially fatal autoimmune disease, characterized by autoantibody production and multi-organ damage...
  20. pmc Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population
    Kayoko Tao
    Department of Immunology and Parasitology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    Ann Rheum Dis 66:905-9. 2007
    b>Systemic lupus erythematosus (SLE) is characterised by dysregulation of autoreactive lymphocytes and antigen-presenting cells...
  21. ncbi Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain
    Medicine (Baltimore) 82:299-308. 2003
    ..study, we assessed the frequency and characteristics of the main causes of morbidity and mortality in systemic lupus erythematosus (SLE) during a 10-year period and compared the frequency of early manifestations with those that ..
  22. pmc Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus
    Alexander R Abbas
    Department of Bioinformatics, Genentech Inc, South San Francisco, CA, USA
    PLoS ONE 4:e6098. 2009
    b>Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease with a complex spectrum of cellular and molecular characteristics including several dramatic changes in the populations of peripheral leukocytes...
  23. pmc Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    Jonathan A Deane
    Laboratory of Immunogenetics, NIAID NIH, Rockville, MD 20852, USA
    Immunity 27:801-10. 2007
    ..These results underscore the importance of tightly regulating expression of TLR7 to prevent spontaneous triggering of harmful autoreactive and inflammatory responses...
  24. ncbi Toll-like receptors in systemic autoimmune disease
    Ann Marshak-Rothstein
    Department of Microbiology, Boston University School of Medicine, 80 East Concord Street, Boston, Massachusetts 02118, USA
    Nat Rev Immunol 6:823-35. 2006
    ....
  25. pmc A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
    Srividya Subramanian
    Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 103:9970-5. 2006
    ....
  26. pmc Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European America
    Yan Yang
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, Columbus, OH 43205, USA
    Am J Hum Genet 80:1037-54. 2007
    ..We investigated the C4 gene CNV in 1,241 European Americans, including patients with systemic lupus erythematosus (SLE), their first-degree relatives, and unrelated healthy subjects, by definitive genotyping and ..
  27. pmc A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs
    Michael F Denny
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 184:3284-97. 2010
    ..They may play an important dual role in premature cardiovascular disease development in systemic lupus erythematosus by simultaneously mediating enhanced vascular damage and inhibiting vascular repair.
  28. pmc Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
    Nan Shen
    Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Proc Natl Acad Sci U S A 107:15838-43. 2010
    b>Systemic lupus erythematosus (SLE) is a multisystem, autoimmune disease that predominantly affects women...
  29. ncbi Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX
    Geoffrey Hom
    Genentech, South San Francisco, CA 94080, USA
    N Engl J Med 358:900-9. 2008
    b>Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions...
  30. ncbi Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients
    F Carrion
    Facultad de Medicina, Universidad de Los Andes, Santiago, Chile
    Lupus 19:317-22. 2010
    ..However, autologous MSC therapy has not been tested in human systemic lupus erythematosus (SLE)...
  31. pmc A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus
    Daniel J Wallace
    Cedars Sinai Medical Center, University of California, Los Angeles, USA
    Arthritis Rheum 61:1168-78. 2009
    To assess the safety, tolerability, biologic activity, and efficacy of belimumab in combination with standard of care therapy (SOC) in patients with active systemic lupus erythematosus (SLE).
  32. ncbi Development and validation of a disease-specific health-related quality of life measure, the LupusQol, for adults with systemic lupus erythematosus
    Kathleen McElhone
    Royal Blackburn Hospital, Blackburn, UK
    Arthritis Rheum 57:972-9. 2007
    To develop and validate a disease-specific health-related quality of life (HRQOL) instrument for adults with systemic lupus erythematosus (SLE).
  33. ncbi Risk factors for cardiovascular disease in systemic lupus erythematosus
    E Svenungsson
    Department of Rheumatology and Centre for Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Circulation 104:1887-93. 2001
    Cardiovascular disease (CVD) is overrepresented in patients with systemic lupus erythematosus (SLE)...
  34. ncbi Apoptosis in the pathogenesis of systemic lupus erythematosus
    L E Munoz
    Department of Internal Medicine 3, Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Lupus 17:371-5. 2008
    b>Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease resulting from autoimmune responses against nuclear autoantigens...
  35. ncbi Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice
    Marie Laure Santiago-Raber
    Department of Pathology and Immunology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Autoimmun 34:339-48. 2010
    ..that TLR7 and TLR9 play pathogenic and protective roles, respectively, in the development of murine systemic lupus erythematosus (SLE)...
  36. pmc Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE
    Vilma Urbonaviciute
    Interdisciplinary Center of Clinical Research IZKF, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, University of Erlangen Nuremberg, Erlangen, Germany
    J Exp Med 205:3007-18. 2008
    Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark of systemic lupus erythematosus (SLE)...
  37. ncbi The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis
    Kirsten Neubert
    Interdisciplinary Center for Clinical Research, research group N2, Nikolaus Fiebiger Center of Molecular Medicine, University Hospital Erlangen, Glückstrasse 6, 91054 Erlangen, Germany
    Nat Med 14:748-55. 2008
    Autoantibody-mediated diseases like myasthenia gravis, autoimmune hemolytic anemia and systemic lupus erythematosus represent a therapeutic challenge...
  38. ncbi A retrospective seven-year analysis of the use of B cell depletion therapy in systemic lupus erythematosus at University College London Hospital: the first fifty patients
    Tim Y T Lu
    University College of London, London, UK
    Arthritis Rheum 61:482-7. 2009
    ..the 6-month clinical outcome and the long-term safety profile of B cell depletion therapy (BCDT) in 50 patients with active systemic lupus erythematosus (SLE), who were nonresponsive or poorly responsive to conventional immunosuppression.
  39. ncbi DNA methylation and systemic lupus erythematosus
    Eva Balada
    Research Unit in Systemic Autoimmune Diseases, Vall d Hebron Research Institute, Hospital Vall d Hebron, Barcelona, Spain
    Ann N Y Acad Sci 1108:127-36. 2007
    Several studies have indicated the importance of DNA hypomethylation in the etiology of systemic lupus erythematosus (SLE). Different enzymes linked to the DNA methylation process have been described...
  40. ncbi Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D?
    H Amital
    Department of Medicine B and Centre for Autoimmune Diseases, Sheba Medical Centre, Affiliated to Tel Aviv University Tel Hashomer 52621, Israel
    Ann Rheum Dis 69:1155-7. 2010
    ..Low serum vitamin D concentrations have been reported in several autoimmune disorders...
  41. pmc Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
    B S Andrews
    J Exp Med 148:1198-215. 1978
    MRL/1 and BXSB male mice have a systemic lupus erythematosus (SLE)-like disease similar to but more acute than that occurring in NZB X W mice...
  42. pmc Interferon and granulopoiesis signatures in systemic lupus erythematosus blood
    Lynda Bennett
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Exp Med 197:711-23. 2003
    b>Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease characterized by flares of high morbidity...
  43. ncbi Features of systemic lupus erythematosus in Dnase1-deficient mice
    M Napirei
    Abteilung für Anatomie und Embryologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum, Germany
    Nat Genet 25:177-81. 2000
    b>Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that affects over one million people in the United States...
  44. pmc Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase
    Philip L Cohen
    Department of Medicine, Division of Rheumatology, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Exp Med 196:135-40. 2002
    ..These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity...
  45. pmc Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study
    Jason W Bauer
    University of Minnesota, Minneapolis, MN 55455, USA
    Arthritis Rheum 60:3098-107. 2009
    b>Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by unpredictable flares of disease activity and irreversible damage to multiple organ systems...
  46. ncbi Clearance deficiency and systemic lupus erythematosus (SLE)
    Udo S Gaipl
    Institute for Clinical Immunology, Department of Internal Medicine 3, Friedrich Alexander University of Erlangen Nuremberg, Glückstrasse 4a, 91054 Erlangen, Germany
    J Autoimmun 28:114-21. 2007
    b>Systemic lupus erythematosus (SLE) is a fairly heterogeneous autoimmune disease. Impaired clearance functions for dying cells may explain accumulation of nuclear autoantigens in various tissues of SLE patients...
  47. pmc Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
    Thomas Dorner
    Department of Medicine Rheumatology and Clinical Immunology, Charite Hospital, Berlin, Germany
    Arthritis Res Ther 8:R74. 2006
    B cells play an important role in the pathogenesis of systemic lupus erythematosus (SLE), so the safety and activity of anti-B cell immunotherapy with the humanized anti-CD22 antibody epratuzumab was evaluated in SLE patients...
  48. ncbi Systemic lupus erythematosus
    David P D'Cruz
    Lupus Research Unit, Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Lancet 369:587-96. 2007
    b>Systemic lupus erythematosus is an autoimmune connective-tissue disorder with a wide range of clinical features, which predominantly affects women, especially from certain ethnic groups...
  49. ncbi Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations
    Johan Frostegard
    Center for Infectious Medicine and Center for Metabolism and Endocrinology, Department of Medicine, Karolinska University Hospital, Huddinge, S 141 86 Stockholm, Sweden
    Arthritis Rheum 52:192-200. 2005
    Cardiovascular disease with premature atherosclerosis is common in patients with systemic lupus erythematosus (SLE)...
  50. ncbi Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus
    Snaevar Sigurdsson
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Hum Mol Genet 17:872-81. 2008
    ..in the interferon regulatory factor 5 (IRF5) gene for their association with the autoimmune disease systemic lupus erythematosus (SLE) in 485 Swedish patients and 563 controls...
  51. pmc Pathogenesis of systemic lupus erythematosus
    C C Mok
    Department of Medicine and Geriatrics, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong
    J Clin Pathol 56:481-90. 2003
    The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved...
  52. pmc Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity
    Gangduo Wang
    University of Texas Medical Branch, Galveston, TX 77555 0438, USA
    Arthritis Rheum 62:2064-72. 2010
    ..reactions have been implicated as contributors in a number of autoimmune diseases, including systemic lupus erythematosus (SLE)...
  53. pmc Pathogenesis of human systemic lupus erythematosus: recent advances
    Jose C Crispin
    Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Trends Mol Med 16:47-57. 2010
    b>Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived from the involvement of multiple organs including the kidneys, joints, nervous system and hematopoietic organs...
  54. ncbi Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus
    Lingyun Sun
    Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, Jiangsu 210008, China
    Arthritis Rheum 62:2467-75. 2010
    ..This study was undertaken to assess the efficacy and safety of allogeneic UC MSCT in patients with severe and treatment-refractory systemic lupus erythematosus (SLE).
  55. ncbi Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden
    N Danchenko
    Lupus 15:308-18. 2006
    b>Systemic lupus erythematosus (SLE) is a disease of multifactorial etiology...
  56. ncbi Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy
    Jennifer H Anolik
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 56:3044-56. 2007
    ..This study was undertaken to determine the magnitude, duration, and cause of these defects in rituximab-treated systemic lupus erythematosus (SLE) patients.
  57. pmc ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity
    Jared M Odegard
    Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
    J Exp Med 205:2873-86. 2008
    ....
  58. pmc Novel evidence-based systemic lupus erythematosus responder index
    Richard A Furie
    North Shore Long Island Jewish Health System, Lake Success, New York, USA
    Arthritis Rheum 61:1143-51. 2009
    To describe a new systemic lupus erythematosus (SLE) responder index (SRI) based on a belimumab phase II SLE trial and demonstrate its potential utility in SLE clinical trials.
  59. pmc Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study
    Annett M Jacobi
    Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Arthritis Rheum 62:201-10. 2010
    To understand the effects of long-term BLyS inhibition in human systemic lupus erythematosus (SLE).
  60. ncbi Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus
    M Odendahl
    Deutsches Rheuma ForschungsZentrum Berlin, Charite University Hospital, Berlin, Germany
    J Immunol 165:5970-9. 2000
    In patients with active systemic lupus erythematosus (SLE), a marked B lymphocytopenia was identified that affected CD19(+)/CD27(-) naive B cells more than CD19(+)/CD27(+) memory B cells, leading to a relative predominance of CD27-..
  61. pmc Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12061-6. 2009
    ..Importantly, this helps provide an explanation for the high frequency of anti-nucleic acid Abs in lupus-like systemic autoimmunity...
  62. ncbi Health-related quality of life in patients with systemic lupus erythematosus: an update
    Julian Thumboo
    Department of Rheumatology and Immunology, Singapore General Hospital, Singapore
    Ann Acad Med Singapore 36:115-22. 2007
    With improvements in mortality in systemic lupus erythematosus (SLE), the functional status of these patients, assessed using health-related quality of life (HRQoL) instruments, is increasingly being recognised as an important outcome ..
  63. ncbi Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus
    Hannes Cash
    Department of Internal Medicine, Division of Rheumatology and Clinical Immunology, Johannes Gutenberg University, Mainz, Germany
    J Rheumatol 37:60-70. 2010
    ..To investigate the pathophysiological effect of interleukin 6 (IL-6) on lupus nephritis in MRL-Fas(lpr) mice...
  64. ncbi Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients
    Philip E Morgan
    The Heart Research Institute, Camperdown, Sydney, NSW, Australia
    Free Radic Res 43:117-27. 2009
    Serum protein oxidation levels in people with the autoimmune disease systemic lupus erythematosus (SLE) have previously been shown to (a) be elevated at a single time point and (b) correlate with disease activity...
  65. ncbi The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus
    E J Córdova
    Instituto Nacional de Medicina Genomica, Mexico City, Mexico
    Lupus 19:1237-42. 2010
    b>Systemic lupus erythematosus (SLE) is an autoimmune disease associated with oxidative stress and characterized by chronic inflammation...
  66. pmc Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    Emily C Baechler
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 100:2610-5. 2003
    b>Systemic lupus erythematosus (SLE) is a complex, inflammatory autoimmune disease that affects multiple organ systems...
  67. ncbi Correlation of lipid peroxidation and glutathione levels with severity of systemic lupus erythematosus: a pilot study from single center
    K Tewthanom
    Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Pharm Pharm Sci 11:30-4. 2008
    b>Systemic Lupus Erythematosus (SLE) is a multifactoral chronic autoimmune disease with unidentified etiology. Imbalance of oxidative status is one possible cause of active disease...
  68. ncbi IgM anti-dsDNA antibodies in systemic lupus erythematosus: negative association with nephritis. SLE Study Group
    T Witte
    Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Germany
    Rheumatol Int 18:85-91. 1998
    Antibodies against dsDNA of the IgM class were measured in sera of 352 patients with systemic lupus erythematosus, 81 blood donors and 189 patients with rheumatoid arthritis using a new ELISA based on human recombinant dsDNA as antigen...
  69. pmc Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study
    Gabor G Illei
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, USA
    Arthritis Rheum 62:542-52. 2010
    To assess the safety of interleukin-6 receptor inhibition and to collect preliminary data on the clinical and immunologic efficacy of tocilizumab in patients with systemic lupus erythematosus (SLE).
  70. pmc The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus
    Michael P Cancro
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104 6082, USA
    J Clin Invest 119:1066-73. 2009
    ..This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE...
  71. ncbi Mutation of DNASE1 in people with systemic lupus erythematosus
    K Yasutomo
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
    Nat Genet 28:313-4. 2001
    b>Systemic lupus erythematosus (SLE) is a highly prevalent human autoimmune diseases that causes progressive glomerulonephritis, arthritis and an erythematoid rash. Mice deficient in deoxyribonuclease I (Dnase1) develop an SLE-like syndrome...
  72. ncbi Identification of regulatory T cells in systemic lupus erythematosus
    Roberto Gerli
    Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Autoimmun Rev 8:426-30. 2009
    ..In recent years, several studies analyzed Treg cell phenotype and function in systemic lupus erythematosus (SLE), the prototypical systemic autoimmune disorder in humans...
  73. ncbi Progressive multifocal leukoencephalopathy: a national estimate of frequency in systemic lupus erythematosus and other rheumatic diseases
    Eamonn S Molloy
    Fasenmeyer Center for Clinical Immunology, Department of Rheumatic and Immunology Diseases, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arthritis Rheum 60:3761-5. 2009
    ..The aim of this study was to generate a national estimate of the frequency of PML among patients with rheumatic diseases...
  74. pmc An antibody profile of systemic lupus erythematosus detected by antigen microarray
    Ittai Fattal
    Department of Nephrology, Rabin Medical Center, Petach Tikva, Israel
    Immunology 130:337-43. 2010
    Patients with systemic lupus erythematosus (SLE) produce antibodies to many different self-antigens. Here, we investigated antibodies in SLE sera using an antigen microarray containing many hundreds of antigens, mostly self-antigens...
  75. pmc Decreased frequency and activated phenotype of blood CD27 IgD IgM B lymphocytes is a permanent abnormality in systemic lupus erythematosus patients
    Beatriz Rodríguez-Bayona
    Unidad de Investigacion, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009 Cadiz, Spain
    Arthritis Res Ther 12:R108. 2010
    b>Systemic lupus erythematosus (SLE) is characterized by B cell hyper-activation and auto-reactivity resulting in pathogenic auto-antibody generation...
  76. ncbi Factors influencing polyautoimmunity in systemic lupus erythematosus
    Adriana Rojas-Villarraga
    Center for Autoimmune Diseases Research CREA, School of Medicine, Rosario University, Bogota, Colombia
    Autoimmun Rev 9:229-32. 2010
    ..e., ADs co-occurring within patients) in systemic lupus erythematosus (SLE) and its associated factors were investigated.
  77. ncbi Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus
    Chi Chiu Mok
    Department of Medicine, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong, SAR China
    Transl Res 156:320-5. 2010
    ..of antinucleosome, anti-C1q, and anti-dsDNA antibodies for detecting concurrent disease activity in systemic lupus erythematosus (SLE)...
  78. ncbi MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus
    Xia Zhao
    Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai RenJi Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institutes for Biological Sciences, and Chinese Academy of Sciences, Shanghai, China
    Arthritis Rheum 62:3425-35. 2010
    ..This study aimed to clarify whether miR-125a, which was identified in a pilot expression profiling step, is involved in the inflammatory chemokine pathway in systemic lupus erythematosus (SLE).
  79. ncbi Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus
    Kwangwoo Kim
    Department of Biological Sciences, KAIST, 335 Gwahangno, Yuseong Gu, Daejeon 305 701, Korea
    Ann Rheum Dis 69:1247-50. 2010
    ..Elevated expression of IFNG has been associated with systemic lupus erythematosus (SLE). This study examined the association of IFNG polymorphisms with SLE susceptibility.
  80. ncbi Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients
    Yaniv Sherer
    Department of Medicine B and Center for Autoimmune Disease, Sheba Medical Center, Tel Hashomer 52621, Israel
    Semin Arthritis Rheum 34:501-37. 2004
    Description of the various autoantibodies that can be detected in patients with systemic lupus erythematosus (SLE).
  81. pmc Angiotensin-converting enzyme inhibitors delay the occurrence of renal involvement and are associated with a decreased risk of disease activity in patients with systemic lupus erythematosus--results from LUMINA (LIX): a multiethnic US cohort
    S Duran-Barragan
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Rheumatology (Oxford) 47:1093-6. 2008
    ..To examine if angiotensin-converting enzyme (ACE) inhibitor use delays the occurrence of renal involvement and decreases the risk of disease activity in SLE patients...
  82. ncbi Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients
    Y Dai
    The Second Clinical Medical College, Jinan University, Shenzhen People s Hospital, Guangdong Province, China
    Lupus 16:939-46. 2007
    ..This study describes a comparison between the miRNA profile of the systemic lupus erythematosus (SLE) patients and the controls to develop further understanding of the pathogenesis of SLE...
  83. ncbi Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms
    Aya Kawasaki
    University of Tsukuba, Tsukuba, Japan
    Arthritis Rheum 58:826-34. 2008
    To determine whether the IRF5 gene, which encodes interferon regulatory factor 5, is associated with systemic lupus erythematosus (SLE) in a Japanese population.
  84. ncbi Vitamin D deficiency in systemic lupus erythematosus
    Diane L Kamen
    Medical University of South Carolina, Charleston, SC, USA
    Autoimmun Rev 5:114-7. 2006
    ..9, p<0.01). These results suggest vitamin D deficiency as a possible risk factor for SLE and provide guidance for future studies looking at a potential role of vitamin D in the prevention and/or treatment of SLE...
  85. ncbi Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study
    Jun Liang
    Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
    Ann Rheum Dis 69:1423-9. 2010
    To determine the safety and efficacy of allogeneic mesenchymal stem cell transplantation (MSCT) in refractory systemic lupus erythematosus (SLE).
  86. pmc The interferon-alpha signature of systemic lupus erythematosus
    G Obermoser
    Baylor Institute for Immunology Research, Dallas, TX, USA
    Lupus 19:1012-9. 2010
    b>Systemic lupus erythematosus (SLE) is a prototypic multisystem autoimmune disorder where interplay of environmental and genetic risk factors leads to progressive loss of tolerance to nuclear antigens over time, finally culminating in ..
  87. pmc Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    John B Harley
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Genet 40:204-10. 2008
    b>Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families (lambda(S) = approximately 30)...
  88. ncbi Safety and efficacy of rituximab in systemic lupus erythematosus: results from 136 patients from the French AutoImmunity and Rituximab registry
    Benjamin Terrier
    Bicetre Hospital, Assistance Publique Hopitaux de Paris, and Paris 11 University, Le Kremlin Bicetre, France
    Arthritis Rheum 62:2458-66. 2010
    A number of open-label studies have suggested the potential benefit of rituximab (RTX) in systemic lupus erythematosus (SLE). However, in 2 recent randomized controlled trials (RCTs) of RTX, the primary end points were not met...
  89. pmc Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus
    Bailin Liang
    Immunobiology, Centocor, Radnor, PA, USA
    Immunology 119:296-305. 2006
    b>Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from dysregulation of the immune system. Interleukin-6 (IL-6) is a multifunctional cytokine produced by macrophages, monocytes and T and B cells...
  90. ncbi The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial
    J T Merrill
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Arthritis Rheum 62:3077-87. 2010
    To evaluate abatacept therapy in patients with non-life-threatening systemic lupus erythematosus (SLE) and polyarthritis, discoid lesions, or pleuritis and/or pericarditis.
  91. ncbi Regulation of B cell tolerance by the lupus susceptibility gene Ly108
    Kirthi Raman Kumar
    Department of Internal Medicine Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 312:1665-9. 2006
    ..1 allele, was found to sensitize immature B cells to deletion and RAG reexpression. As a potential regulator of tolerance checkpoints, Ly108 may censor self-reactive B cells, hence safeguarding against autoimmunity...
  92. ncbi Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus
    Kyriakos A Kirou
    Hospital for Special Surgery, and Weill Medical College of Cornell University, New York, New York 10021, USA
    Arthritis Rheum 50:3958-67. 2004
    ..of interferon-alpha (IFNalpha) and IFNgamma to the IFN gene expression signature that has been observed in microarray screens of peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE).
  93. ncbi Neuropsychiatric syndromes in lupus: prevalence using standardized definitions
    R L Brey
    Department of Medicine, Division of Neurology, San Antonio, TX 78229 3900, USA
    Neurology 58:1214-20. 2002
    The San Antonio Lupus Study of Neuropsychiatric Disease is a longitudinal study designed to characterize the spectrum of and important risk factors for specific neuropsychiatric systemic lupus erythematosus (NPSLE) syndromes.
  94. pmc Understanding the epidemiology and progression of systemic lupus erythematosus
    Guillermo J Pons-Estel
    Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Semin Arthritis Rheum 39:257-68. 2010
    This review examines the burden and patterns of disease in systemic lupus erythematosus (SLE) and the influence and interactions of gender, ethnicity, age, and psychosocial attributes with respect to disease progression, focusing on ..
  95. ncbi Systemic lupus erythematosus: all roads lead to type I interferons
    Virginia Pascual
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Suite 205, Dallas, TX 75204, USA
    Curr Opin Immunol 18:676-82. 2006
    In recent years, the study of systemic lupus erythematosus (SLE) patients has revealed a central role for type I interferon (IFN) in disease pathogenesis...
  96. pmc Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
    L Morel
    Departments of Medicine and Pathology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 97:6670-5. 2000
    ..and identify the pathway occupied by Sle1 as a strategic target for therapeutic intervention in systemic lupus erythematosus. The coexpression of Sle1, Sle2, and Sle3 as a B6-triple congenic results in severe systemic ..
  97. ncbi Type I interferon in systemic lupus erythematosus and other autoimmune diseases
    Jacques Banchereau
    Baylor Institute for Immmunology Research, 3434 Live Oak, Dallas, Texas 75204, USA
    Immunity 25:383-92. 2006
    Different genetic alterations may lead to type I interferon (IFN) overproduction in human systemic lupus erythematosus (SLE)...
  98. ncbi Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus
    Robert Biesen
    Charite Universitatsmedizin Berlin, Humboldt University of Berlin, Germany
    Arthritis Rheum 58:1136-45. 2008
    Type I interferon (IFN) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE) and is therefore considered a potential therapeutic target...
  99. ncbi Mortality in systemic lupus erythematosus
    S Bernatsky
    Montreal General Hospital, Montreal, Quebec, Canada
    Arthritis Rheum 54:2550-7. 2006
    To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled.
  100. pmc Interferon-alpha promotes abnormal vasculogenesis in lupus: a potential pathway for premature atherosclerosis
    Michael F Denny
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Blood 110:2907-15. 2007
    Individuals with systemic lupus erythematosus (SLE) have a striking increase in premature atherosclerosis of unclear etiology. Accelerated endothelial cell apoptosis occurs in SLE and correlates with endothelial dysfunction...
  101. ncbi Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus
    Irith Baumann
    Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 46:191-201. 2002
    To investigate the fate of apoptotic cells in the germinal centers (GCs) of patients with systemic lupus erythematosus (SLE).

Research Grants70

  1. Immune Regulation of Bone Homeostasis
    MERVYN NEALE WEITZMANN; Fiscal Year: 2012
    ..amelioration of numerous conditions including Crohn's disease, psoriasis and psoriatic arthritis, systemic lupus erythematosus;multiple sclerosis;Type I Diabetes, and as anti-rejection agents following solid organ and bone marrow ..
  2. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..aPL) antibodies (Abs) are associated with thrombosis and pregnancy loss in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS)...
  3. Regulation of B Cell Function by Membrane-Cytoskeletal Remodeling
    Neetu Gupta; Fiscal Year: 2012
    ..Malfunctioning B cells are associated with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis...
  4. Oklahoma Autoimmunity Center of Excellence
    Judith A James; Fiscal Year: 2013
    ..The research projects focus on thrombotic thrombocytopenic purpura, systemic lupus erythematosus, and Sj"gren's syndrome, which are also focuses of the Clinical Center...
  5. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..25(OH)VD3 have been reported in patients with autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type I diabetes mellitus (DM) and multiple sclerosis (MS)...
  6. Regulation of Type 1 Interferon Production by Autoimmunity-Associated PTPN22
    Yaya Wang; Fiscal Year: 2013
    ..IFN) represents a candidate shared mechanism of enhanced susceptibility to diverse syndromes including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Type I diabetes (T1D)...
  7. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..g. toxicant exposures) and lifestyle choices (e.g. diet). Notably, the risk of developing systemic lupus erythematosus (lupus), a prototypical autoimmune disease affecting 300,000 Americans and often associated with ..
  8. Predictors of Pregnancy Outcome in SLE and APS
    Jane E Salmon; Fiscal Year: 2012
    ..PROMISSE Study (Predictors of pRegnancy Outcome: bioMarkers In antiphospholipid antibody Syndrome and Systemic lupus Erythematosus) is a first-time effort to translate our novel findings in mice to humans and determine if elevations ..
  9. A rational approach to liver toxicity monitoring in methotrexate users
    Gabriela Schmajuk; Fiscal Year: 2013
    ..upon her prior work which evaluated quality measures and patient safety in rheumatoid arthritis and systemic lupus erythematosus (JAMA 2011;305(5):480;Semin Arthritis Rheum 2011;40(6):559), the proposed series of projects will ..
  10. Comparative Effectiveness Research in Pediatric Rheumatic Diseases: Leveraging CA
    CAROL A contact WALLACE; Fiscal Year: 2010
    ..Protocols will be initially developed in four disease areas: Juvenile Idiopathic Arthritis [JIA], Systemic Lupus Erythematosus [SLE], Juvenile Dermatomyositis [JDM] and Localized Scleroderma...
  11. Statins &Lymphoid Malignancy Risk in a Large Multi-Site Population-Based Cohort
    Marianne Ulcickas Yood; Fiscal Year: 2013
    ..e., rheumatoid arthritis, systemic lupus erythematosus, and Sjvgren's syndrome)...
  12. Gene Transcription in SLE
    George C Tsokos; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is an autoimmune disorder of largely unknown etiology characterized by profound T cell effector dysfunction...
  13. Progression of Autoimmunity During Puberty in SLE
    KATHLEEN M O'NEIL; Fiscal Year: 2011
    Researchers have puzzled for decades over why many autoimmune diseases like systemic lupus erythematosus (SLE) disproportionately affect women...
  14. The Role of CD5 in B-Cell Development and Autoimmunity
    Chander Raman; Fiscal Year: 2012
    ..of chronic systemic autoimmune diseases such as rheumatoid arthritis (RA), Sjogren's syndrome and systemic lupus erythematosus (SLE)...
  15. Lysosomal phospholipase A2 in autoimmune disease
    JAMES ALAN SHAYMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus historically has been and still remains a poorly understood autoimmune disorder...
  16. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..autoantibodies can either initiate or worsen inflammation in patients with rheumatoid arthritis or systemic lupus erythematosus. It is difficult to eliminate these autoantibodies once they are formed...
  17. Gender Bias in Lupus: Contribution of Sex Chromosomes
    Ram Raj Singh; Fiscal Year: 2012
    b>Systemic lupus erythematosus (SLE) is an autoimmune disease that occurs more in females than males at a ratio of 9:1...
  18. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..The diseases we will target include systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, multiple sclerosis, and type I diabetes mellitus...
  19. The Role of Sex in Self Antigen Generation in SLE
    David Stephen Pisetsky; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that primarily affects young women and powerfully exemplifies the importance of sex as a determinant of immune-mediated disease...
  20. Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?
    Bryce Binstadt; Fiscal Year: 2012
    ..For example, patients with rheumatoid arthritis or systemic lupus erythematosus (SLE) are at increased risk for developing coronary artery disease...
  21. Matrix Otopathology
    MICHAEL ANNE NMI GRATTON; Fiscal Year: 2011
    ..Nevertheless, animal models of diabetes mellitus, systemic lupus erythematosus, presbycusis, and Alport's syndrome exhibit abnormally thick strial capillary basement membranes ..
  22. Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory Response
    Gary S Gilkeson; Fiscal Year: 2013
    Abstract Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by autoantibody production and immune complex mediated organ damage...
  23. HLA-D Region in Systemic Lupus Erythematosus Pathogenesis
    Shu Man Fu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is a prototype of systemic autoimmune disease that affects predominantly females in their productive ages. It causes significant morbidity and mortality...
  24. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..5% of the US population is affected by an autoimmune disorder such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or multiple sclerosis (MS)...
  25. Translational Approaches to Reducing Health Disparities in Lung Disease
    Joe G N Garcia; Fiscal Year: 2012
    ..Acute Lung Injury;4. Interstitial lung diseases (idiopathic pulmonary fibrosis, sarcoidosis, systemic lupus erythematosus);and 5. Lung Cancer...
  26. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012
    ..2: Women with endometriosis are at greater risk of autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus (SLE), and Grave's disease...
  27. Sex chromosome aneuploidies in autoimmune disease
    R Hal Scofield; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is a disease that can affect any organ. The disease has a complicated pathogenesis involving many aspects of the immune system, including acquired and innate...
  28. The Role of CRACM1 in the Pathogenesis of Systemic Lupus Erythematosus
    Peter C Chien; Fiscal Year: 2013
    ..The program will involve the study of autoimmunity, immunology, cell signaling, and specifically systemic lupus erythematosus. The PI's scientific development will be mentored by Jean-Pierre Kinet, M.D...
  29. NADPH-Oxidase and SLE Susceptibility
    Swapan K Nath; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE or lupus) is a complex, multi-organ, clinically heterogeneous, potentially fatal autoimmune disease with substantial genetic and environmental components. In U.S...
  30. The role of neutrophil extracellular traps and NADPH oxidase in SLE pathogenesis
    ALLISON MARIE CAMPBELL; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes significant morbidity and mortality. Its prevalence is 400 cases per 100,000 in African American women...
  31. MECHANISMS OF AUTOIMMUNITY IN SLE
    David Stephen Pisetsky; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANA) in association with multisystem inflammatory ..
  32. AUTOIMMUNITY CENTER OF EXCELLENCE
    David Wofsy; Fiscal Year: 2013
    ..This proposal focuses primarily on three of these diseases (systemic lupus erythematosus, multiple sclerosis, and type 1 diabetes mellitus), but we also describe active programs in several ..
  33. Therapeutic Value of Fish Oil Rx on SLE and Bone Loss in Mice
    GABRIEL J J FERNANDES; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is an autoimmune disease affecting over 1 million Americans, mostly women, which is influenced by both genetic and environmental risk factors and shortens the life ..
  34. The Effects of C-Reactive Protein on Autoimmunity
    Terry W Du Clos; Fiscal Year: 2013
    ..b>Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoantibodies against nuclear antigens...
  35. Developing small molecule therapeutics for lupus
    Thomas R Coleman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) affects ~ 2 million Americans with devastating impact on multiple organs, especially the skin, joints, kidney, and brain...
  36. Post Translational Modifications in Tolerance and Autoimmunity
    Mark J Mamula; Fiscal Year: 2012
    ..detailed a novel property of self proteins that may confer autoimmune responses in murine models of systemic lupus erythematosus (SLE)...
  37. Urine biomarkers of lupus nephritis pathology and response to therapy
    James C Oates; Fiscal Year: 2013
    ..year after start of induction therapy will be characterized by the American College of Rheumatology and Systemic Lupus Erythematosus International Cooperating Clinics renal response criteria...
  38. Caspase 8: A Novel Suppressor of Dendritic Cell-Mediated Autoimmunity
    Carla M Cuda; Fiscal Year: 2013
    ..b>Systemic lupus erythematosus (SLE) is a multi-organ and destructive autoimmune disease characterized by pathogenic autoantibodies...
  39. The Role of Complement in the Pathogenesis of Preeclampsia
    MICHAEL PAUL TRIEBWASSER; Fiscal Year: 2013
    ..from the PROMISSE study (Predictors of pregnancy Outcome: biomarkers In antiphospholipid Syndrome and Systemic lupus Erythematosus). Rare variants were discovered in 7 of the 40 cases and in none of the 33 controls...
  40. The Contribution of Protein Methylation in Systemic Lupus Erythematosus
    Hester A Doyle; Fiscal Year: 2011
    b>Systemic lupus erythematosus (SLE) in humans is characterized by autoantibody production to a variety of self-proteins...
  41. GILT and regulation of Treg development in cutaneous autoimmunity
    KAREN TARASZKA HASTINGS; Fiscal Year: 2013
    ..of cutaneous autoimmune and inflammatory diseases, such as vitiligo, psoriasis, atopic dermatitis and systemic lupus erythematosus. T cell receptor stimulation is a major factor which determines Treg cell differentiation...
  42. Oxidative Stress and Autoimmunity
    M Firoze Khan; Fiscal Year: 2013
    ..can elicit autoimmune responses by stimulating T and B lymphocytes, eventually leading to ADs such as systemic lupus erythematosus (SLE)...
  43. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2010
    b>Systemic lupus erythematosus (SLE) is a common multisystem autoimmune disease that is estimated to affect more than 500,000 Americans...
  44. Mapping Expression Quantitative Trait Loci with Next Generation Sequencing in SLE
    Min Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is an autoimmune disease that leads to chronic inflammation and may affect any part of the body, especially the skin, joints, kidneys, brain, and blood...
  45. B cell metabolism in activation and autoantibody production
    Jeffrey C Rathmell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Immunological diseases such as Systemic Lupus Erythematosus (SLE) are driven by disruption of regulatory mechanisms in both T and B lymphocytes leading to autoantibody production and inflammation...
  46. Progesterone &Estrogen Differentially Regulate DC Function in Lupus Autoimmunity
    Grant Hughes; Fiscal Year: 2012
    ..In systemic lupus erythematosus (SLE), tolerance is broken through aberrant activation and homeostasis of DCs...
  47. RNA quality control and environmental stress
    Sandra L Wolin; Fiscal Year: 2013
    ..failure to degrade cellular RNAs contributes to neurologic disorders and to autoimmune diseases such as systemic lupus erythematosus (SLE), little is known of the molecules and pathways that degrade most aberrant RNAs in mammalian cells...
  48. Cervical Dysplasia and Human Papillomavirus Infection in Rheumatoid Arthritis.
    SEOYOUNG CATHERINE KIM; Fiscal Year: 2013
    ..Previous studies have suggested that women with immunocompromised conditions including systemic lupus erythematosus, systemic sclerosis and ulcerative colitis are at a greater risk for cervical dysplasia and human ..
  49. Towards Measures of Lupus Nephritis Activity &Damage for Children
    Hermine I Brunner; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Although childhood-onset Systemic Lupus Erythematosus (cSLE) has similar disease manifestations as SLE in adults, children often have more severe multi-organ involvement, and up to 80% of them have ..
  50. IMMUNE RESPONSES IN LUPUS
    Joseph Craft; Fiscal Year: 2013
    ..function of these cells have been less clearly defined in both normal individuals and in patients with systemic lupus erythematosus than other CD4 T cell effector subsets...
  51. Molecular Markers in Discoid Lupus Erythematous
    BENJAMIN FRANKLIN CHONG; Fiscal Year: 2013
    ..Because of its association with systemic lupus erythematosus (SLE), discoid skin lesions represent an untapped, yet easily accessible resource that could bear great ..
  52. Gender-Specific Role of Aim2 in Inflammation and Autoimmunity
    Divaker Choubey; Fiscal Year: 2011
    ..Moreover, our studies will help in the rational design of new therapies and treatments for chronic inflammatory diseases, including systemic lupus erythematosus (SLE).
  53. Pediatric Nephrology Seminar XXXIX
    GASTON E ZILLERUELO; Fiscal Year: 2012
    ..kidney disease, and the effects of systemic diseases on the kidneys, including Sickle Cell nephropathy, Systemic Lupus Erythematosus, and Hemolytic Uremic Syndrome...
  54. Somatic hypermutation and class switching in autoimmunity
    Paolo Casali; Fiscal Year: 2013
    ..This proposal addresses the molecular mechanisms of the generation of pathogenic autoantibodies in systemic lupus erythematosus (SLE): immunoglobulin (antibody) somatic hypermutation (SHM) and class switch DNA recombination (CSR)...
  55. The Role of T Lymphocytes in Hypertension During Chronic Inflammatory Disease
    KEISA WILLIAMS MATHIS; Fiscal Year: 2013
    ..b>Systemic lupus erythematosus (SLE) is a chronic inflammatory disorder estimated to affect nearly 2 million people in the United ..
  56. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2013
    ..provided by applicant): Antibodies to double stranded (ds) DNA are not only highly specific for systemic lupus erythematosus (SLE), but are also directly involved in the pathogenesis of lupus nephritis (LN), a major disease ..
  57. Immune and genetic determinants of murine glomerulonephritis
    Elahna Paul; Fiscal Year: 2012
    ..CD48-/-) develop autoimmunity with severe glomerulonephritis (CD48GN) that is reminiscent of human systemic lupus erythematosus. In addition to chronic kidney disease, features of the B6...
  58. Health Systems, Quality of Care, and Outcomes in SLE
    Edward H Yelin; Fiscal Year: 2012
    ..applicant): Prior research has firmly established both that persons of lower socioeconomic status with systemic lupus erythematosus (SLE) experience poorer access to care, actual health care utilization, and outcomes due in part to the ..
  59. MicroRNA expression in the NZB/W lupus mouse
    CHRISTOPHER MICHAEL REILLY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Extensive analysis of both genetics and environmental pathogens of systemic lupus erythematosus (SLE) has yet to reveal a common mechanism for the initiation of disease...
  60. Interferon Alpha: The Link Between Lupus and Endothelial Dysfunction
    JOY N BUIE; Fiscal Year: 2013
    ..is initiated by severe vascular endothelial dysfunction (VED), a phenotype common amongst systemic lupus erythematosus (SLE) patients...
  61. TNIP1 risk haplotypes and immune endophenotypes
    Peter K Gregersen; Fiscal Year: 2013
    ..regulated by TNIP1, a gene which has been associated with a variety of autoimmune diseases, including systemic lupus erythematosus (SLE), systemic sclerosis, and psoriasis, and more recently rheumatoid arthritis...
  62. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is a common multisystem autoimmune disease that is estimated to affect more than 500,000 Americans...
  63. STUDY OF DEXAMETHASONE IN NEONATAL LUPUS CHB
    Jill Buyon; Fiscal Year: 2004
    ..a model of passively acquired autoimmunity whereby immune abnormalities in the mother (who may have systemic lupus erythematosus, Sjogrens syndrome, or be entirely asymptomatic) lead to the production of antibodies to the SSA/Ro-SSB/..
  64. Libman-Sacks Endocarditis and NPSLE
    Carlos Roldan; Fiscal Year: 2009
    ..Libman-Sacks endocarditis with vegetations is the most serious heart disease of systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) which includes stroke and transient ischemic ...
  65. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2005
    DESCRIPTION: (Adapted from the Investigator's abstract): Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by immune complex glomerulonephritis and infiltration of activated macrophages into the ..
  66. Do estrogen receptors in B cells and DC mediate sex bias in murine lupus?
    Susan Kovats; Fiscal Year: 2009
    b>Systemic lupus erythematosus (SLE) is an autoimmune disease that preferentially affects women (9:1) in their reproductive years, indicating that sex specific factors including the sex hormone estradiol play an important role in lupus ..
  67. Efficacy Measures for Pediatric Lupus Studies
    Hermine Brunner; Fiscal Year: 2009
    apos;ROJECT SUMMARY: Childhood-onset Systemic Lupus Erythematosus (cSLE) is a severe autoimmune disease and better medications are urgently needed to decrease its mortality...
  68. Non-Invasive Approaches to Assessing Inflammation (RMI)
    RYAN SARTOR; Fiscal Year: 2006
    ..inflammatory disorders, including immune-mediated arthritis, diabetes, inflammatory bowel diseases, systemic lupus erythematosus (SLE), glomerulonephritis, vasculitis, atherosclerosis and asthma, a major impediment to their ..
  69. Gender-Specific Role of p202 in Lupus Susceptibility
    Divaker Choubey; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE) is an autoimmune disease. The disease develops at a female-to-male ratio of 10:1...
  70. Recombinant Fc receptor therapeutics for systemic lupus erythematosus
    Periasamy Selvaraj; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Systemic lupus erythematosus (SLE or lupus) is a systemic autoimmune disease that affects multiple organs and has a high incidence in women and African Americans...