discoid lupus erythematosus

Summary

Summary: A chronic form of cutaneous lupus erythematosus (LUPUS ERYTHEMATOSUS, CUTANEOUS) in which the skin lesions mimic those of the systemic form but in which systemic signs are rare. It is characterized by the presence of discoid skin plaques showing varying degrees of edema, erythema, scaliness, follicular plugging, and skin atrophy. Lesions are surrounded by an elevated erythematous border. The condition typically involves the face and scalp, but widespread dissemination may occur.

Top Publications

  1. ncbi Current treatment of cutaneous lupus erythematosus
    V Werth
    Department of Dermatology, University of Pennsylvania, USA
    Dermatol Online J 7:2. 2001
  2. ncbi Periorbital oedema and erythema as a manifestation of discoid lupus erythematosus
    R P Braun
    Department of Dermatology, University Hospital, Geneva, Switzerland
    Dermatology 205:194-7. 2002
  3. ncbi Pimecrolimus 1% cream for cutaneous lupus erythematosus
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    J Am Acad Dermatol 51:407-10. 2004
  4. ncbi [Lupus erythematosus or human immunodeficiency virus infection? Diagnostic problems in rheumatologic practice--two case reports]
    Beata Nowak
    Zakład Reumatologii AM we Wrocławiu
    Pol Arch Med Wewn 114:1098-102. 2005
  5. ncbi Optical coherence tomography of cutaneous lupus erythematosus correlates with histopathology
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Lupus 16:35-8. 2007
  6. ncbi Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxA
    J Wenzel
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Br J Dermatol 153:1011-5. 2005
  7. ncbi Association between discoid lupus erythematosus and cigarette smoking
    Hélio Amante Miot
    Dermatology Department, UNESP Medical School, Botucatu, Brazil
    Dermatology 211:118-22. 2005
  8. ncbi Efficacy and safety of pulsed dye laser treatment for cutaneous discoid lupus erythematosus
    Angelina Erceg
    Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 60:626-32. 2009
  9. ncbi Preliminary evaluation of in vivo reflectance confocal microscopy features of Discoid lupus erythematosus
    M Ardigo
    San Gallicano Dermatological Institute, IRCCS, Via Chianesi 53, 00144 Rome, Italy
    Br J Dermatol 156:1196-203. 2007
  10. pmc Lenalidomide for the treatment of resistant discoid lupus erythematosus
    Asha Shah
    Department of Dermatology, University of Pennsylvania, 3600 Spruce St, Philadelphia, PA 19104, USA
    Arch Dermatol 145:303-6. 2009

Detail Information

Publications223 found, 100 shown here

  1. ncbi Current treatment of cutaneous lupus erythematosus
    V Werth
    Department of Dermatology, University of Pennsylvania, USA
    Dermatol Online J 7:2. 2001
    ..The antimalarials remain the cornerstone of treatment because of their effectiveness and safety. Optimal use of the antimalarials as well as alternative therapy options are discussed...
  2. ncbi Periorbital oedema and erythema as a manifestation of discoid lupus erythematosus
    R P Braun
    Department of Dermatology, University Hospital, Geneva, Switzerland
    Dermatology 205:194-7. 2002
    ..Since swelling of the eyelid is common in the dermatological practice, dermatologists should be aware of the differential diagnosis and its occurrence in patients with DLE...
  3. ncbi Pimecrolimus 1% cream for cutaneous lupus erythematosus
    Alexander Kreuter
    Department of Dermatology and Allergology, Ruhr University Bochum, Germany
    J Am Acad Dermatol 51:407-10. 2004
    ..001). This was an open and uncontrolled study on a limited number of cases. We suggest that pimecrolimus 1% cream could be an efficacious and safe treatment option for cutaneous lupus erythematosus...
  4. ncbi [Lupus erythematosus or human immunodeficiency virus infection? Diagnostic problems in rheumatologic practice--two case reports]
    Beata Nowak
    Zakład Reumatologii AM we Wrocławiu
    Pol Arch Med Wewn 114:1098-102. 2005
    ..The aim of the article is to stress the importance of a very careful differentiating of SLE and HIV infection...
  5. ncbi Optical coherence tomography of cutaneous lupus erythematosus correlates with histopathology
    T Gambichler
    Department of Dermatology, Ruhr University Bochum, Bochum, Germany
    Lupus 16:35-8. 2007
    ..Nevertheless, the current technique does not allow one to visualize definite diagnostic features of cutaneous LE. However, OCT may be a promising method for objective monitoring of LE activity and treatment effects over time in vivo...
  6. ncbi Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxA
    J Wenzel
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Br J Dermatol 153:1011-5. 2005
    ..T cells, but failed to explain the development of scarring skin lesions, characteristic for chronic discoid lupus erythematosus (CDLE)...
  7. ncbi Association between discoid lupus erythematosus and cigarette smoking
    Hélio Amante Miot
    Dermatology Department, UNESP Medical School, Botucatu, Brazil
    Dermatology 211:118-22. 2005
    b>Discoid lupus erythematosus (DLE) is a chronic cutaneous disease affecting photoexposed areas and has also been associated with cigarette smoking.
  8. ncbi Efficacy and safety of pulsed dye laser treatment for cutaneous discoid lupus erythematosus
    Angelina Erceg
    Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 60:626-32. 2009
    Treatment of chronic discoid lupus erythematosus (CDLE) with a pulsed dye laser (PDL) has shown promising results, although outcomes in previous studies were not validated and laser parameters were inconsistent.
  9. ncbi Preliminary evaluation of in vivo reflectance confocal microscopy features of Discoid lupus erythematosus
    M Ardigo
    San Gallicano Dermatological Institute, IRCCS, Via Chianesi 53, 00144 Rome, Italy
    Br J Dermatol 156:1196-203. 2007
    b>Discoid lupus erythematosus (DLE) can simulate other inflammatory diseases both clinically and histologically...
  10. pmc Lenalidomide for the treatment of resistant discoid lupus erythematosus
    Asha Shah
    Department of Dermatology, University of Pennsylvania, 3600 Spruce St, Philadelphia, PA 19104, USA
    Arch Dermatol 145:303-6. 2009
    b>Discoid lupus erythematosus (DLE) is a chronic, disfiguring disease that is characterized by scaly, erythematous, disk-shaped patches and plaques followed by atrophy, scarring, and dyspigmentation...
  11. ncbi Follicular red dots: a novel dermoscopic pattern observed in scalp discoid lupus erythematosus
    Antonella Tosti
    Department of Dermatology, University of Bologna, Via Massarenti 1, 40138, Bologna, Italy
    Arch Dermatol 145:1406-9. 2009
    ....
  12. ncbi Early diagnosis and treatment of discoid lupus erythematosus
    Suresh Panjwani
    Bounces Road Surgery, Forest Primary Care Centre, London, UK
    J Am Board Fam Med 22:206-13. 2009
    b>Discoid lupus erythematosus is a chronic dermatological disease that can lead to scarring, hair loss, and hyperpigmentation changes in skin if it is not treated early and promptly...
  13. ncbi Discoid lupus erythematosus masquerading as chronic blepharoconjunctivitis
    Nisha Acharya
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 112:e19-23. 2005
    To recognize discoid lupus erythematosus (DLE) as a treatable cause of chronic blepharoconjunctivitis.
  14. ncbi Coexistence of osteopoikilosis and discoid lupus erythematosus: a case report
    A Bicer
    Mersin University, Mersin, Turkey
    Clin Rheumatol 21:405-7. 2002
    ..We report a case of osteopoikilosis and discoid lupus erythematosus presenting with skin and mucosal involvement, an association that has never previously been reported...
  15. ncbi Treatment of resistant discoid lupus erythematosus of the palms and soles with mycophenolate mofetil
    S Goyal
    Department of Dermatology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    J Am Acad Dermatol 45:142-4. 2001
    ..Expanding the use of this agent in dermatology, we describe 2 patients with both systemic lupus erythematosus and discoid lupus erythematosus whose recalcitrant palmoplantar lesions were successfully treated with mycophenolate mofetil.
  16. ncbi Lupus erythematosus tumidus and chronic discoid lupus erythematosus in carriers of X-linked chronic granulomatous disease
    R A Rupec
    Department of Dermatology and Allergology, Ludwig Maximilians University, Frauenblobstr 9 11, D 80337 Munich, Germany
    Eur J Dermatol 10:184-9. 2000
    ..lupus erythematosus (LE) with clinically and morphologically characteristic appearance for chronic discoid lupus erythematosus (DLE) and lupus erythematosus tumidus (LET)...
  17. ncbi Squamous cell carcinoma in black patients with discoid lupus erythematosus
    Wakisa K Mulwafu
    Division of Otolaryngology, University of Cape Town
    S Afr J Surg 44:144-6. 2006
    ..We report on 2 further cases, the first to be reported in southern Africa, of squamous cell carcinoma in lesions of discoid lupus erythematosus
  18. ncbi Systemic and discoid lupus erythematosus in HIV-infected patients treated with highly active antiretroviral therapy
    Leonardo Calza
    Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Italy
    Int J STD AIDS 14:356-9. 2003
    ..Two HIV-infected female patients with SLE and discoid lupus erythematosus (DLE) diagnosed a few months after the highly active antiretroviral therapy initiation, are described...
  19. ncbi Pimecrolimus 1% cream versus betamethasone 17-valerate 0.1% cream in the treatment of facial discoid lupus erythematosus: a double-blind, randomized pilot study
    B Barikbin
    Skin Research Centre, Shahid Beheshti University, M C, Shohada e Tajrish Hospital, Tehran, Iran
    Clin Exp Dermatol 34:776-80. 2009
    b>Discoid lupus erythematosus (DLE) is commonly treated with topical agents, the most important of which are glucocorticosteroids...
  20. ncbi The effect of topical tacrolimus on severe recalcitrant chronic discoid lupus erythematosus
    S L Walker
    Br J Dermatol 147:405-6. 2002
  21. ncbi Pimecrolimus 1% cream for the treatment of discoid lupus erythematosus
    A Tlacuilo-Parra
    Medical Research Division, UMAE, Hospital de Pediatria, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, Mexico
    Rheumatology (Oxford) 44:1564-8. 2005
    To determine the safety and efficacy of pimecrolimus cream on lesions of discoid lupus erythematosus.
  22. ncbi Evaluation of the profile of the immune cell infiltrate in lichen planus, discoid lupus erythematosus, and chronic dermatitis
    Mahmoud Rezk A Hussein
    Department of Pathology, Faculty of Medicine, Assuit University Hospitals, Assuit, Egypt
    Pathology 40:682-93. 2008
    ..This investigation tries to test this hypothesis and to characterise immune cells in interface dermatitis...
  23. ncbi Efalizumab in the treatment of discoid lupus erythematosus
    Naila Usmani
    Department of Dermatology, Leeds General Infirmary, Great George St, Leeds LS1 3EX, England
    Arch Dermatol 143:873-7. 2007
    b>Discoid lupus erythematosus is a chronic inflammatory condition in which the pathogenesis and the role of cell-mediated immunity remains unclear...
  24. ncbi Dramatic response of scarring scalp discoid lupus erythematosus (DLE) to intravenous methylprednisolone, oral corticosteroids, and hydroxychloroquine in a 5-year-old child
    Paivi M H Miettunen
    Division of Rheumatology, Department of Pediatrics, University of Calgary, Calgary, Canada
    Pediatr Dermatol 26:338-41. 2009
    b>Discoid lupus erythematosus (DLE) is rare in childhood. We report the case of a 5-year-old girl who presented with erythematous scaly plaques, with scarring alopecia, involving approximately 40% of her scalp...
  25. ncbi The circulating lymphocyte profiles in patients with discoid lupus erythematosus and systemic lupus erythematosus suggest a pathogenetic relationship
    C H P Wouters
    Department of Dermatology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Br J Dermatol 150:693-700. 2004
    b>Discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) are chronic inflammatory diseases of unknown aetiology; the relationship of DLE with SLE has been a subject of debate for many years...
  26. ncbi Treatment of chronic discoid lupus erythematosus with topical tacrolimus
    Daniel de la Rosa Carrillo
    Acta Derm Venereol 84:233-4. 2004
  27. ncbi 0.1% tacrolimus ointment in the treatment of discoid lupus erythematosus
    Michael P Heffernan
    Arch Dermatol 141:1170-1. 2005
  28. ncbi Childhood discoid lupus erythematosus: a Tunisian retrospective study of 16 cases
    Faika Cherif
    Department of Dermatology, La Rabta Hospital, Tunis, Tunisia
    Pediatr Dermatol 20:295-8. 2003
    b>Discoid lupus erythematosus (DLE) is uncommon in children. The clinical features of childhood DLE are similar to those of adult DLE in presentation and chronic course...
  29. ncbi A randomized controlled trial of R-salbutamol for topical treatment of discoid lupus erythematosus
    G B E Jemec
    Department of Dermatology, Health Sciences Faculty, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark
    Br J Dermatol 161:1365-70. 2009
    In a recent open pilot trial, R-salbutamol sulphate, a well-known molecule with anti-inflammatory effects, was tested successfully on patients with therapy-resistant discoid lupus erythematosus (DLE).
  30. ncbi Discoid lupus erythematosus presenting as madarosis
    Dinesh Selva
    Oculoplastic and Orbital Clinic, Department of Ophthalmology, Royal Adelaide Hospital, University of Adelaide, South Australia, Australia
    Am J Ophthalmol 136:545-6. 2003
    b>Discoid lupus erythematosus (DLE) is an autoimmune disorder that usually affects the sun-exposed skin. Periocular involvement occurs uncommonly and may progress from eyelid erythema to scarring and madarosis.
  31. ncbi Discoid lupus erythematosus in children: clinical, histopathologic, and follow-up features in 27 cases
    Celia Moises-Alfaro
    Department of Pediatric Dermatology, National Institute of Pediatrics, Mexico City, Mexico
    Pediatr Dermatol 20:103-7. 2003
    Among 27 pediatric patients with a clinicopathologic diagnosis of discoid lupus erythematosus (DLE), 15 had localized cutaneous lesions and 12 had disseminated lesions...
  32. ncbi Successful treatment with topical tacrolimus in four cases of discoid lupus erythematosus
    Masayoshi Sugano
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Dermatol 33:887-91. 2006
    b>Discoid lupus erythematosus (DLE), a cutaneous form of lupus erythematosus, is characterized as atrophic and scaly erythema and the lesions are often refractory to a wide range of topical or systemic therapies...
  33. ncbi [Discoid lupus erythematosus with eyelid involvement. A series of nine patients]
    M Mseddi
    Service de Dermatologie, Sfax, Tunisie
    J Fr Ophtalmol 30:247-9. 2007
    b>Discoid lupus erythematosus (DLE) is a chronic autoimmune skin disease that usually affects the sun-exposed skin. Palpebral involvement occurs uncommonly.
  34. ncbi A trial of low-dose UVA1 phototherapy for two patients with recalcitrant discoid lupus erythematosus
    A Mitra
    Clin Exp Dermatol 31:299-300. 2006
  35. ncbi Discoid lupus erythematosus exacerbated by radiation therapy
    Akemi Ishida-Yamamoto
    J Dermatol 32:225-6. 2005
  36. ncbi Discoid lupus erythematosus exacerbated by contact dermatitis caused by use of squaric acid dibutylester for topical immunotherapy in a patient with alopecia areata
    Yayoi Shimaoka
    Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Dermatol 35:151-3. 2008
    A 57-year-old Japanese male patient with an 18-year history of discoid lupus erythematosus (DLE) presented with alopecia on his scalp, and was clinically diagnosed to have alopecia areata...
  37. ncbi Evidence of reduced plasma HDL subfractions in patients with cutaneous discoid lupus erythematosus
    Irene Lagogianni
    Department of Biological Chemistry, University of Athens School of Medicine, Goudi 74, Athens 11527, Greece
    Clin Biochem 38:286-90. 2005
    The aim of the present study was to evaluate the dyslipidemic profile of patients with Cutaneous Discoid Lupus Erythematosus (DLE) with particular emphasis on the levels of High Density Lipoprotein (HDL) Cholesterol and its subfractions, ..
  38. ncbi [Successful therapy of discoid lupus erythematosus with efalizumab]
    N Booken
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, 68135, Mannheim
    Hautarzt 61:246-9. 2010
    The therapy of discoid lupus erythematosus (DLE) is occasionally a therapeutic challenge. Topical treatment is often not sufficient and therapy with antimalarials [(hydroxy-) chloroquine] not always successful...
  39. ncbi Cicatricial alopecia: discoid lupus erythematosus
    Maria Hordinsky
    Department of Dermatology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Dermatol Ther 21:245-8. 2008
    Chronic cutaneous lupus erythematosus consists of three major dermatologic diseases: discoid lupus erythematosus (DLE), lupus panniculitis/lupus profundus, and lupus tumidus (Table 1)...
  40. ncbi Detection of type 1 cytokines in discoid lupus erythematosus
    J R Toro
    National Cancer Intitute, National Institutes of Health, Building 10, Room 12N 238, 10 Center Dr, MSC 1908, Bethesda, MD 20892 1908, USA
    Arch Dermatol 136:1497-501. 2000
    Although multiple studies suggest a dysregulated T-cell cytokine production in systemic lupus erythematosus, the cytokine profile in discoid lupus erythematosus (DLE) lesions is unknown.
  41. ncbi Discoid lupus erythematosus in children--a retrospective study of 34 patients
    Maria Carolina de Abreu Sampaio
    Department of Dermatology, Hospital das Clinicas, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Pediatr Dermatol 25:163-7. 2008
    b>Discoid lupus erythematosus is much less frequent and studied in children. We undertook a retrospective study of 34 children less than 16 years of age with this disease, seen over a period of 9 years...
  42. ncbi Systematic administration of chloroquine in discoid lupus erythematosus reduces skin lesions via inhibition of angiogenesis
    A Lesiak
    Department of Dermatology, Medical University of Lodz, Poland
    Clin Exp Dermatol 34:570-5. 2009
    b>Discoid lupus erythematosus (DLE) is a chronic cutaneous form of lupus erythematosus, characterized by inflammation and scarring skin lesions, with lymphocyte infiltration and vasodilation...
  43. ncbi Immunoglobulin M predominance in cutaneous lupus erythematosus
    Andrew P Kontos
    Department of Dermatology, Henry Ford Health System, Detroit, MI, USA
    J Cutan Pathol 32:352-5. 2005
    ..Our goal was to characterize the most frequent immune reactants in the skin biopsies of cutaneous LE and identify the most common immunofluorescence staining patterns...
  44. ncbi Role of the chemokine receptor CCR4 and its ligand thymus- and activation-regulated chemokine/CCL17 for lymphocyte recruitment in cutaneous lupus erythematosus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Invest Dermatol 124:1241-8. 2005
    ..Our investigations suggest that CCR4 and TARC/CCL17 play a role in the pathophysiology of CLE. In particular, cytotoxic CD8+ T cells expressing CCR4 appear to be involved in scarring subtypes of CLE...
  45. ncbi [Cutaneous lesions in lupus erythematosus]
    J Wenzel
    Klinik und Poliklinik fur Dermatologie, Universitatsklinikum Bonn
    Dtsch Med Wochenschr 128:1655-8. 2003
  46. ncbi Systemic sclerosis with unusual panniculitis and overlying discoid lupus erythematosus-like lesions
    Hiroshi Oka
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dtsch Dermatol Ges 3:627-9. 2005
    ..men presented with systemic sclerosis accompanied by both unusual panniculitis and overlying discoid lupus erythematosus (DLE)-like skin changes on the left buttock...
  47. ncbi Cutaneous warts in patients with lupus erythematosus
    Cengiz Korkmaz
    Division of Rheumatology, Department of Internal Medicine, Osmangazi University, Eskisehir, Turkey
    Rheumatol Int 24:137-40. 2004
    ..The findings suggest that the high prevalence of CW in patients with LE is probably due to defects in some immune mechanisms, independently of immunosuppressive drugs...
  48. ncbi Cutaneous lupus erythematosus: a personal approach to management
    Jeffrey P Callen
    Division of Dermatology, University of Louisville, Louisville, Kentucky 40292, USA
    Australas J Dermatol 47:13-27. 2006
    ..The skin lesions that are represented by the interface dermatitis include discoid lupus erythematosus, subacute cutaneous lupus erythematosus and acute cutaneous lupus erythematosus...
  49. ncbi [Cutaneous lupus erythematosus. Part 1: clinical manifestations and classification]
    A Kuhn
    Hautklinik der Heinrich Heine Universität Düsseldorf
    Hautarzt 57:251-67; quiz 268. 2006
    ..The first part of this review will enable the reader to identify the various clinical manifestations of CLE and to employ characteristic criteria to assess differential diagnostic considerations...
  50. ncbi Topical tacrolimus therapy of resistant cutaneous lesions in lupus erythematosus: a possible alternative
    C E Lampropoulos
    Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London SE1 7EH, UK
    Rheumatology (Oxford) 43:1383-5. 2004
    ..To determine the efficacy of tacrolimus ointment 0.1% on resistant cutaneous lesions in patients with lupus erythematosus...
  51. ncbi Collagen vascular diseases
    Jeffrey P Callen
    Division of Dermatology, University of Louisville School of Medicine, KY 40292, USA
    J Am Acad Dermatol 51:427-39. 2004
  52. ncbi The effects of daily stress and stressful life events on the clinical symptomatology of patients with lupus erythematosus
    Maria I Peralta-Ramírez
    Department of Clinical Psychology, School of Psychology, University of Granada, Granda, Spain
    Psychosom Med 66:788-94. 2004
    ..Toward this end, we considered two types of stressors-daily stress and high-intensity stressful life events...
  53. ncbi Tumid lupus erythematosus: an unusual scleredema-like presentation
    Carol A K Roper
    Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Skinmed 5:92-4. 2006
    ..A diagnosis of tumid lupus erythematosus mimicking scleredema was made. Hydroxychloroquine therapy was started at a dose of 200 mg and, at 2 months' follow-up, the patient's symptoms and appearance were improved...
  54. ncbi Hyperkeratotic nail discoid lupus erythematosus evolving towards systemic lupus erythematosus: therapeutic difficulties
    B Richert
    University of Liege, Quai G Kurth, 45, B 4020 Liege, Belgium
    J Eur Acad Dermatol Venereol 18:728-30. 2004
    ..Nailbed hyperkeratosis may be observed in both SLE and discoid lupus erythematosus (DLE). Involvement of the nail apparatus in DLE is extremely uncommon and never restricted to it...
  55. ncbi [Unilateral periorbital tumefaction]
    M Dumont-Berset
    Service de dermatologie et vénérologie, Centre Hospitalier Universitaire Vaudois CHUV, DHURDV, Lausanne, Suisse
    Ann Dermatol Venereol 133:191-3. 2006
  56. ncbi Arcuate plantar plaques as the initial sign of chronic cutaneous lupus in a child
    Tracy Evans-Ramsey
    Department of Pediatrics, Kaiser Permanente Medical Center, Oakland, California, USA
    J Am Acad Dermatol 49:S270-1. 2003
    ..She responded to oral hydrochloroquine with resolution of her skin lesions. This report highlights the unusual presentation of a case of chronic cutaneous lupus with a plantar skin eruption...
  57. ncbi Activation/inactivation of the classical pathway of complement in non-lesional skin of patients with systemic lupus erythematosus
    A Alahlafi
    Department of Dermatology, Oxford Radcliffe Hospital, Oxford, UK
    J Cutan Pathol 32:537-40. 2005
    ..The expression of proteins that regulate complement has not been previously investigated in the skin of patients with SLE...
  58. ncbi Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Germany
    J Pathol 205:435-42. 2005
    ..It is proposed that type I IFNs induce a Th1-biased inflammatory immune response, with recruitment of CXCR3-expressing T-lymphocytes into the skin...
  59. ncbi Identification of retroviral DNA sequences in serum of cutaneous forms of lupus erythematosus patients
    Janusz Prokop
    Department of Dermatology, University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland
    Eur J Dermatol 13:354-8. 2003
    ..Our findings suggest that the presence of endogenous retroviral sequences in patient serum may exhibit a relationship with development of cutaneous forms of LE disease...
  60. ncbi Photosensitivity in patients with lupus erythematosus: a clinical and photobiological study of 100 patients using a prolonged phototest protocol
    C J G Sanders
    Department of Dermatology and Allergology, University Medical Centre, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Br J Dermatol 149:131-7. 2003
    ..Phototesting using artificial UVR and visible light is a reliable way of diagnosing photosensitivity...
  61. ncbi Cutaneous lupus erythematosus: diagnosis and management
    Paolo Fabbri
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    Am J Clin Dermatol 4:449-65. 2003
    ..Patient education regarding the disease is also important in the management of CLE, because it helps relieve undue anxiety and to recruit the patient as an active participant in the treatment regimen...
  62. pmc Quality of life and disease severity in a cutaneous lupus erythematosus pilot study
    Elizabeth Gaines
    Arch Dermatol 144:1061-2. 2008
  63. ncbi The CD40/CD40 ligand system in the skin of patients with subacute cutaneous lupus erythematosus
    Marzia Caproni
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    J Rheumatol 34:2412-6. 2007
    ..To investigate whether CD40 and CD40 ligand (CD40L) is expressed in the skin of patients with subacute cutaneous lupus erythematosus (SCLE)...
  64. ncbi Discoid and subacute lupus erythematosus treated with 0.5% R-salbutamol cream
    Hans Christian Wulf
    Arch Dermatol 143:1589-90. 2007
  65. ncbi Systemic lupus erythematosus with generalized chronic cutaneous (discoid) lupus erythematosus
    Chicky Dadlani
    Department of Dermatology, New York University, USA
    Dermatol Online J 14:5. 2008
    ..features were consistent with systemic lupus erythematosus in a patient with generalized chronic discoid lupus erythematosus. This subtype is a distinct lupus erythematosus subset that rarely develops renal disease and has a ..
  66. ncbi Comparison of anti 60 and 52 kDa SS-A/Ro antibodies in the pathogenesis of cutaneous lupus erythematosus
    Takashi Yoshimasu
    Department of Dermatology, Wakayama Medical University, Wakayama, Japan
    J Dermatol Sci 29:35-41. 2002
    ..However, both type antibodies seemed to have little contribution to the pathogenesis of DLE skin lesion...
  67. ncbi The value of lymphocytopenia as a marker of systemic involvement in cutaneous lupus erythematosus
    J Wenzel
    Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Br J Dermatol 146:869-71. 2002
    ..Recent studies revealed some markers indicating systemic manifestations of CLE patients. However, the significance of diminished peripheral lymphocyte numbers as a marker of systemic involvement in CLE has not been investigated before...
  68. ncbi [Lichen sclerosus et atrophicus--a diagnostic problem]
    Z Golusin
    Klinika za kozno-venericne bolesti, Klinicki centar, Medicinski fakultet, Novi Sad
    Med Pregl 54:187-90. 2001
    ..DISCUSSION: Differentiation between chronic discoid lupus erythematosus and LSA presents a diagnostic challenge...
  69. doi High frequency of vitamin D deficiency among patients with cutaneous lupus erythematosus [corrected]
    J Renne
    Br J Dermatol 159:485-6. 2008
  70. ncbi A protective effect of glutathione-S-transferase GSTP1*Val(105) against polymorphic light eruption
    Thomas P Millard
    Department of Photobiology, St John s Institute of Dermatology, London, UK
    J Invest Dermatol 128:1901-5. 2008
    ..in patients with lupus erythematosus (LE) including subacute cutaneous lupus erythematosus (SCLE) and discoid lupus erythematosus (DLE), which may reflect a common genetic background...
  71. ncbi Matrix metalloproteinases as mediators of tissue injury in different forms of cutaneous lupus erythematosus
    T M Järvinen
    Department of Dermatology, Helsinki University Central Hospital and Biomedicum Helsinki, University of Helsinki, Meilahdentie 2, 00250 Helsinki, Finland
    Br J Dermatol 157:970-80. 2007
    ..Although some MMPs associate with organ manifestations of systemic lupus erythematosus (SLE), their role in cutaneous lupus erythematosus (LE) is elusive...
  72. ncbi Cutaneous lupus erythematosus: a review
    Purvisha Patel
    University of Virginia, Charlottesville, VA, USA
    Dermatol Clin 20:373-85, v. 2002
    ..CLE patients who exhibit these symptoms should be monitored closely, since they may be at increased risk to develop SLE...
  73. ncbi [Classification of dermatologic manifestations in lupus erythematosus]
    Camille Frances
    Service de Medecine Interne, Hopital de la Pitie, 83, Boulevard de l Hopital, 75651 Paris Cedex 13
    Ann Med Interne (Paris) 154:33-44. 2003
    ..An accurate diagnosis is absolutely necessary since therapy is different in thrombosis and vasculitis. Non vascular and non lupus lesions are numerous, some of them require special treatment such as dapsone for bullous lupus...
  74. ncbi Coexisting pseudoxanthoma elasticum and lupus erythematosus: report of two cases
    Julie Le Scanff
    Department of Internal Medicine, Hotel Dieu, Lyon, France
    Int J Dermatol 46:622-4. 2007
    ..Given the ocular and vascular complications of PXE, clinicians who treat patients with lupus should be aware of this possible association...
  75. ncbi Treatment of lupus erythematosus with pulsed dye laser
    Ofelia Baniandrés
    Department of Dermatology, Hospital Ramó y Cajal, Madrid, Spain
    Lasers Surg Med 32:327-30. 2003
    ..The improvement of telangiectasias and chronic erythema of the cutaneous lesions was based on the selective photothermolysis ablation of the dilated capillaries and venules...
  76. ncbi Conversion of discoid lupus to antiphospholipid syndrome and SLE
    Michelle M A Fernando
    Section of Molecular Genetics and Rheumatology, Faculty of Medicine, Imperial College, London, UK
    Nat Clin Pract Rheumatol 4:106-10. 2008
    ..He had a history of discoid lupus erythematosus, complex partial seizures, cerebral thromboses associated with antiphospholipid syndrome (APS) and ..
  77. ncbi Linear childhood discoid lupus erythematosus following the lines of Blaschko: a case report with review of the linear manifestations of lupus erythematosus
    J J Green
    UMDNJ-Robert Wood Johnson Medical School at Camden, New Jersey, USA
    Pediatr Dermatol 16:128-33. 1999
    Seventeen cases of childhood discoid lupus erythematosus (DLE) have been previously reported in the literature. We describe the first reported case of childhood linear DLE following the lines of Blaschko...
  78. ncbi Systemic lupus erythematosus in childhood
    Marisa Klein-Gitelman
    Division of Immunology Rheumatology, Department of Pediatrics, Children s Memorial Hospital, Northwestern University, Chicago, IL, USA
    Rheum Dis Clin North Am 28:561-77, vi-vii. 2002
    ..Perhaps the most essential point in treating a child with lupus is to be aware and concerned about how to deliver treatment to a patient in the middle of their physical, intellectual, and emotional development...
  79. ncbi FACS monitoring of lymphocyte-subsets in patients with discoid and subacute-cutaneous lupus erythematosus receiving low-dose methotrexate
    Ingrid Boehm
    Department of Dermatology, University of Bonn, Germany
    Scand J Rheumatol 31:216-20. 2002
    ..Our purpose was to describe and characterize the influence of low-dose methotrexate (MTX) treatment on absolute counts of peripheral blood cells and lymphocyte subsets in patients with cutaneous lupus erythematosus (LE)...
  80. ncbi Cicatricial alopecia: classification and histopathology
    Najwa Somani
    Departments of Dermatology and Dermatopathology, Cleveland Clinic Health System, Cleveland, Ohio 44195, USA
    Dermatol Ther 21:221-37. 2008
    ..The primary cicatricial alopecias often share overlapping features. The highest diagnostic yield is procured when histology is correlated with the clinical presentation...
  81. doi Chronic cutaneous lupus in childhood: a report of two cases and review of the literature
    Cheryl Bansal
    Int J Dermatol 47:525-6. 2008
  82. ncbi Scarring alopecia in discoid lupus erythematosus: a clinical, histopathologic and immunopathologic study
    P Fabbri
    Second Dermatology Clinic, Department of Dermatological Sciences, University of Florence, Florence, Italy
    Lupus 13:455-62. 2004
    Scarring alopecia is a very frequent feature of chronic discoid lupus erythematosus (DLE)...
  83. ncbi Neonatal lupus erythematosus and maternal lupus erythematosus mimicking HELLP syndrome
    S Paton
    Dermatology Program, Children's Hospital, Boston, Massachusetts
    Pediatr Dermatol 10:177-81. 1993
    ..The patient had elevated Ro(SSA) and La(SSB) antibody titers, and studies performed on maternal blood disclosed positive antinuclear antibodies and elevated Ro and La antibody titers...
  84. ncbi The demonstration of SS-A/Ro antigen in human fetal tissues and in neonatal and adult skin
    L A Lee
    J Invest Dermatol 85:143-6. 1985
    ..We have shown that SS-A/Ro antigen is a normal component of tissues that may be affected in neonatal lupus (fetal myocardium, neonatal epidermis) and in subacute cutaneous lupus erythematosus (adult epidermis)...
  85. ncbi Anti-SSA/Ro antibody as a risk factor for fluorouracil-induced drug eruptions showing acral erythema and discoid-lupus-erythematosus-like lesions
    Atsuko Adachi
    Department of Dermatology, Hyogo Prefectural Kakogawa Hospital, Kakogawa, Japan
    Dermatology 214:85-8. 2007
    ..It is well known that fluorouracil (FU) agents frequently induce discoid-lupus-erythematosus (DLE)-like eruptions and acral erythema in Japan. However, the etiology of these drug eruptions caused by FU agents has not been clarified yet...
  86. ncbi Lupus erythematosus panniculitis: a clinicopathologic study
    Patricia Pei Lin Ng
    National Skin Centre, Singapore
    Int J Dermatol 41:488-90. 2002
    ..Lupus erythematosus panniculitis is a clinical variant of lupus erythematosus which involves the deep dermis and the subcutaneous fat. The purpose of this study was to ascertain the clinical profile of Asian patients with this condition...
  87. ncbi Palpebral involvement as a presenting and sole manifestation of discoid lupus erythematosus
    Reza Yaghoobi
    Department of Dermatology, Jundishapur University of Medical Sciences, Ahvaz, Iran
    ScientificWorldJournal 10:2130-1. 2010
    ..Biopsy specimen was obtained and diagnosis of discoid lupus erythematosus (DLE) was made...
  88. ncbi Thalidomide: a re-look
    J K Grover
    Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Natl Med J India 13:132-41. 2000
    ..dermatological conditions, thalidomide has been found to be effective in systemic lupus erythematosus, discoid lupus erythematosus, actinic prurigo and prurigo nodularis...
  89. ncbi Infiltrating cells, related cytokines and chemokine receptors in lesional skin of patients with dermatomyositis
    M Caproni
    Department of Dermatological Sciences, University of Florence, Florence, Italy
    Br J Dermatol 151:784-91. 2004
    ..There have been only two reports on immunophenotypic characterization in the cutaneous lesions of dermatomyositis (DM) that emphasize the importance of the infiltrating CD4+ T lymphocytes...
  90. ncbi Thalidomide: an experience in therapeutic outcome and adverse reactions
    Nand L Sharma
    Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, India
    J Dermatolog Treat 18:335-40. 2007
    ..The US FDA-approved thalidomide for the treatment of chronic recurrent/severe erythema nodosum leprosum. Thalidomide is also useful in many other inflammatory dermatological conditions where patients have exhausted other treatment options...
  91. pmc Keratinocytes from patients with lupus erythematosus show enhanced cytotoxicity to ultraviolet radiation and to antibody-mediated cytotoxicity
    F Furukawa
    Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Exp Immunol 118:164-70. 1999
    ..ADCC experiments were also performed using keratinocytes cultured from patients with SLE, SCLE, discoid lupus erythematosus (DLE), and normal controls...
  92. pmc Practical management of hair loss
    J Shapiro
    Division of Dermatology, University of British Columbia UBC, Vancouver
    Can Fam Physician 46:1469-77. 2000
    ..To describe an organized diagnostic approach for both nonscarring and scarring alopecias to help family physicians establish an accurate in-office diagnosis. To explain when ancillary laboratory workup is necessary to confirm the diagnosis...
  93. ncbi Hair loss in elderly women
    WenChieh Chen
    Department of Dermatology and Allergy, Technische Universitat Munchen, Munich, Germany
    Eur J Dermatol 20:145-51. 2010
    ..preexisting diseases such as androgenetic alopecia usually worsen after menopause, while others, like discoid lupus erythematosus, may attenuate...
  94. ncbi Association of a promoter polymorphism of tumor necrosis factor-alpha with subacute cutaneous lupus erythematosus and distinct photoregulation of transcription
    V P Werth
    The University of Pennsylvania, VA Hospital, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 115:726-30. 2000
    ..lupus erythematosus, an extremely photosensitive form of cutaneous lupus erythematosus, but not in discoid lupus erythematosus, a less photosensitive form...
  95. ncbi Topical tacrolimus and pimecrolimus in the treatment of cutaneous lupus erythematosus: an evidence-based evaluation
    Thrasivoulos George Tzellos
    Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Eur J Clin Pharmacol 64:337-41. 2008
    ..CLE is one of the most common dermatological autoimmune disorders worldwide, which includes systemic lupus erythematosus (SLE) with malar rash, subacute cutaneous lupus erythematosus (SCLE) and discoid lupus erythematosus (DLE).
  96. ncbi The epidemiology of Graves' disease: evidence of a genetic and an environmental contribution
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    J Autoimmun 34:J307-13. 2010
    ..mellitus, Hashimoto/hypothyroidism, pernicious anemia, polymyositis/dermatomyositis, myasthenia gravis, discoid lupus erythematosus and localized scleroderma. Remarkably, there was a high disease concordance of 2.75 between spouses...
  97. ncbi Cardiomyopathy related to antimalarial therapy with illustrative case report
    Nathalie Costedoat-Chalumeau
    Service de Medecine Interne, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Cardiology 107:73-80. 2007
    ..one case of cardiotoxicity in a 59-year-old woman treated with antimalarials during 13 years for a discoid lupus erythematosus. She progressively developed conduction disturbances and congestive heart failure (CHF)...
  98. ncbi High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis--is this a cutaneous manifestation of IgG4-related disease?
    Aya Miyagawa-Hayashino
    Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto 606 8507, Japan
    Hum Pathol 40:1269-77. 2009
    ..ratios of IgG4+ to IgG+ plasma cells were assessed using skin biopsy specimens with pemphigus (n = 7), discoid lupus erythematosus (n = 5), and morphea (n = 2) (mean ratios, 19%, 0%, and 0%, respectively); we noted the proportion of ..
  99. ncbi Genetic association of cutaneous neonatal lupus with HLA class II and tumor necrosis factor alpha: implications for pathogenesis
    Robert M Clancy
    Department of Rheumatology, Hospital for Joint Diseases, New York University School of Medicine, New York, New York 10003, USA
    Arthritis Rheum 50:2598-603. 2004
    ..Accordingly, this study was undertaken to seek genetic and histologic evidence for a role of TNFalpha in the pathogenesis of cutaneous neonatal lupus...
  100. ncbi Thalidomide: a review of approved and investigational uses
    S James Matthews
    Department of Pharmacy Practice, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, USA
    Clin Ther 25:342-95. 2003
    ..Its immunomodulatory, anti-inflammatory, and antiangiogenic properties are currently under study in a number of clinical conditions...
  101. ncbi Treatment of lupus skin involvement with quinacrine and hydroxychloroquine
    I Cavazzana
    Rheumatology Unit and Chair A O Spedali Civili di Brescia Università degli Studi di Brescia, Italy
    Lupus 18:735-9. 2009
    ..b>Discoid lupus erythematosus (19 cases), acute malar rash (6 cases), chilblain lupus (4 cases) showed a significant improvement with ..

Research Grants8

  1. Molecular Markers in Discoid Lupus Erythematous
    BENJAMIN FRANKLIN CHONG; Fiscal Year: 2013
    ..My mentored research project centers on discoid lupus erythematosus (DLE), a disease whose etiology is not well understood...
  2. Cardiac myofibroblasts in autoimmune-associated CHB
    Robert Clancy; Fiscal Year: 2002
    ....
  3. Identifying the Vitiligo Related SLE Gene on 17p13
    SWAPAN NATH; Fiscal Year: 2004
    ..abstract_text> ..
  4. Visual outcomes & quality of life in CMV retinitis
    Jennifer Thorne; Fiscal Year: 2006
    ..abstract_text> ..
  5. Clinical Basis Investigations into MLS/Leopard Syndrome
    Theresa Pacheco; Fiscal Year: 2007
    ..D. is an Assistant Professor of Dermatology and is committed to a career in clinical research with an focus on molecular markers of disease (pigmentation anomalies) and patient-oriented research topics. ..
  6. Identifying the novel SLE susceptibility gene on 5p15.3
    SWAPAN NATH; Fiscal Year: 2009
    ..By applying both molecular genetic and genetic epidemiological techniques, this project has the potential to narrow the candidate region to a sufficiently small interval to identify this SLE susceptibility gene. ..
  7. Endothelial reactivity and nitric oxide synthetase activity in the ALMS (Aspreva
    Robert Clancy; Fiscal Year: 2009
    ..Relevance to public health: The association of markers/indices of NOS2 expression with mechanism of action of a successful drug treatment in lupus nephritis would be a major advance. ..