Genomes and Genes
giant cell tumor of bone
Summary: A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
Publications235 found, 100 shown here
- [Giant cell tumor of bone with rapid malignant course]M R Lachat
Klinik für Rheumatologie und Rehabilitation, Stadtspital Triemli, Zurich, Switzerland
Orthopade 33:344-8. 2004..Following the diagnosis of giant cell tumor of bone (GCT) on biopsy and curettage, a rapid malignant course was observed with recurrence 2.5 months later...
- The origin of the neoplastic stromal cell in giant cell tumor of boneManuela Wülling
Department of Bone Pathology Center of Biomechanics, University Hospital Hamburg Eppendorf, Germany
Hum Pathol 34:983-93. 2003Fibroblastlike stromal cells, which are always present as a component of giant cell tumor of bone (GCT), can be observed in both in vivo and cultured cell samples...
- Giant cell tumor of the extremity: A review of 349 cases from a single institutionCostantino Errani
Musculoskeletal Oncology Department, Istituto Ortopedico Rizzoli, Bologna, Italy
Cancer Treat Rev 36:1-7. 2010..Special attention must be given to giant cell tumors not only in the distal radius, but also in the proximal femur, where the treatment is more difficult and associated with a higher rate of local recurrence...
- A short-term in vivo model for giant cell tumor of boneMaurice Balke
Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Center, Ostmerheimer Str, Cologne, Germany
BMC Cancer 11:241. 2011Because of the lack of suitable in vivo models of giant cell tumor of bone (GCT), little is known about its underlying fundamental pro-tumoral events, such as tumor growth, invasion, angiogenesis and metastasis...
- Giant cell tumor of the extremity: retrospective analysis of 621 Chinese patients from one institutionXiaohui Niu
Department of Orthopedic Oncology Surgery, Beijing Ji Shui Tan Hospital, Peking University, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China
J Bone Joint Surg Am 94:461-7. 2012..The present study was designed to review the epidemiological characteristics and outcomes of surgical management in a large series of Chinese patients with giant cell tumor of an extremity, treated at a single institution...
- A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastasesIra J Miller
Department of Orthopedic Surgery, Rush University Medical Center, 1611 W, Harrison 300 Chicago, IL, 60612, USA
Diagn Pathol 5:62. 2010..Here we report a case of GCT of bone that at the time of recurrence was found to have undergone malignant transformation. Concurrent metastases were found in the lung, but these were non-transformed GCT...
- Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 studyDavid Thomas
Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
Lancet Oncol 11:275-80. 2010..We investigated the potential therapeutic effect of denosumab, a fully human monoclonal antibody against RANKL, on tumour-cell survival and growth in patients with GCT...
- Giant cell tumor of bone. The role of fibroblast growth factor 3 positive mesenchymal stem cells in its pathogenesisDror Robinson
Department of Orthopedics A Assaf Harofeh Medical Center, Zerifin, Israel
Pathobiology 70:333-42. 2002b>Giant cell tumor of bone is typified by massive infiltration of a bland neoplastic stroma by osteoclasts and monocyte progenitors...
- Giant cell tumor of bone: a basic science perspectiveRobert W Cowan
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
Bone 52:238-46. 2013Comprehending the pathogenesis of giant cell tumor of bone (GCT) is of critical importance for developing novel targeted treatments for this locally-aggressive primary bone tumor...
- Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of boneSam Behjati
1 Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK 2 Department of Paediatrics, University of Cambridge, Cambridge, UK 3
Nat Genet 45:1479-82. 2013..Gly34Arg or p.Gly34Val alterations in childhood brain tumors, a remarkable picture of tumor type specificity for histone H3.3 driver alterations emerges, indicating that histone H3.3 residues, mutations and genes have distinct functions. ..
- Giant cell tumor of bone: review, mimics, and new developments in treatmentCorey J Chakarun
Department of Radiology, Keck School of Medicine, University of Southern California, 1500 San Pablo St, 2nd Floor Imaging, Los Angeles, CA 90033 5313, USA
Radiographics 33:197-211. 2013..Denosumab, a monoclonal antibody that targets the osteoclastic activity of GCT, has produced 90% tumor necrosis in early studies, results indicative of promise as a potential adjuvant therapy...
- Can p63 serve as a biomarker for giant cell tumor of bone? A Moroccan experienceNawal Hammas
Department of Pathology, Hassan II University Hospital, Harazem, Fez, Morocco
Diagn Pathol 7:130. 2012..Differential diagnosis can be challenging, particularly in instances of limited sampling. The purpose of this study was to evaluate the contribution of the P63 in the positive and differential diagnosis of giant cell tumor of bone.
- Giant cell tumor of boneKevin A Raskin
Massachusetts General Hospital, Boston, MA, USA
J Am Acad Orthop Surg 21:118-26. 2013..Medical therapy and radiotherapy can alter the management of GCT of bone, especially in multifocal disease, local recurrences, and bulky central/axial disease...
- Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumorYuhree Kim
Department of Orthopaedic Surgery, Columbia University Medical Center, Columbia University, New York, NY 10032, USA
Clin Orthop Surg 4:107-16. 2012..Consistent with this paradigm, a recombinant RANK-Fc protein and bisphosphonates are currently being tried for GCT treatment in addition to surgical excision and conventional topical adjuvant therapies...
- Giant cell tumor of boneAlan W Yasko
Department of Orthopedic Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 444, Houston, TX 77030, USA
Curr Oncol Rep 4:520-6. 2002b>Giant cell tumor of bone is an enigmatic osseous neoplasm that is histologically benign but clinically shows local aggression and metastatic potential...
- The treatment of sacral giant-cell tumours by serial arterial embolisationR D Lackman
Department of Orthopaedic Surgery, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA
J Bone Joint Surg Br 84:873-7. 2002..They remained free from growth, recurrence, or metastases at follow-up (4 to 17 years). One patient died from metastatic disease within 18 months of the initial diagnosis...
- Which treatment is the best for giant cell tumors of the distal radius? A meta-analysisYu Peng Liu
Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China
Clin Orthop Relat Res 470:2886-94. 2012..However, it is unclear whether one provides lower rates of recurrences and fewer complications, and whether the use of polymethylmethacrylate (PMMA) after curettage reduces the risk of recurrence...
- RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of boneSophie Roux
Rheumatology Department, Bicetre Hospital, Le Kremlin Bicetre, France
Am J Clin Pathol 117:210-6. 2002..Our results suggest that RANKL expression may have a role in the pathogenesis of GCTBs and in the formation of the large OC population present in these tumors...
- Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysisAmalia Conti
Laboratory of Experimental Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
Am J Pathol 178:88-97. 2011b>Giant cell tumor of bone can be locally aggressive and occasionally can metastasize in the lungs...
- Factors of local recurrence of giant cell tumor of long bone after treatment: plain radiographs, pathology and surgical proceduresKullanuch Chanchairujira
Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand
J Med Assoc Thai 94:1230-7. 2011..To evaluate the relationship between local recurrence of giant cell tumor (GCT) after surgical treatments and plain radiography, pathology grade and surgical procedures...
- Phenol as an adjuvant for local control in the treatment of giant cell tumour of the boneH R Dürr
Department of Orthopedics and Orthopedic Surgery, Ludwig Maximilians University Munich, Klinikum Grosshadern, Marchioninistr 15, Munich, D 81366, Germany
Eur J Surg Oncol 25:610-8. 1999..Due to the combined use of phenol and cementation in most studies, the effect of phenol alone is described in this study...
- A clinicopathological study of giant cell tumor of small bonesMichiro Yanagisawa
Department of Orthopedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
Ups J Med Sci 116:265-8. 2011..The purpose of this study was to investigate and report the clinicopathological features of 11 cases with small-bone GCT...
- Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of boneIsabella W Y Mak
McMaster University, Hamilton, Ontario, Canada L8V 5C2
Hum Pathol 41:1320-9. 2010b>Giant cell tumor of bone (GCT) is an aggressively osteolytic primary bone tumor that is characterized by the presence of abundant multinucleated osteoclast-like giant cells, hematopoietic monocytes, and a distinct mesenchymal stromal cell ..
- Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of boneIsabella W Y Mak
Department of Surgery, McMaster University, Hamilton, Ontario, Canada
Bone 45:377-86. 2009b>Giant Cell Tumor of bone (GCT) is an aggressively osteolytic and cytokine-rich bone tumor...
- Properties of the stromal cell in giant cell tumor of boneMichelle Ghert
McMaster University, Hamilton Health Sciences and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
Clin Orthop Relat Res 459:8-13. 2007..The spindle like stromal cells of GCT have characteristics of osteoblast progenitors and produce active matrix-degrading proteases. These cells may therefore play a central role in bone destruction...
- Cathepsin K is the principal protease in giant cell tumor of boneJan H N Lindeman
Department of Biomedical Research, TNO Prevention and Health, PO Box 2215, 2301 CE Leiden, The Netherlands
Am J Pathol 165:593-600. 2004..Inhibition of cathepsin K or its associated proton-pump may provide new therapeutic opportunities for GCT...
- Expression of preosteoblast markers and Cbfa-1 and Osterix gene transcripts in stromal tumour cells of giant cell tumour of boneL Huang
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China
Bone 34:393-401. 2004..In summary, our data suggest that GCT stromal tumour cells may have an osteoblastic lineage and retain the ability to differentiate into osteoblasts...
- Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapyWolfgang T Becker
Orthopädische Klinik Volmarstein, Universitat Witten Herdecke, Wetter, Germany
J Bone Joint Surg Am 90:1060-7. 2008The use of adjuvants after curettage has been well established for the treatment of giant cell tumor of bone. The purpose of this study was to analyze the rates of recurrence following different types of treatment as well as the influence ..
- Giant cell tumor of bone express p63Brendan C Dickson
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
Mod Pathol 21:369-75. 2008..The purpose of this study was to investigate p63 expression in giant cell tumor of bone and to determine whether it can be used to discriminate between other giant cell-rich tumors...
- Intralesional curettage for grades II and III giant cell tumors of boneRichard D Lackman
University of Pennsylvania, Philadelphia, PA 19106 6192, USA
Clin Orthop Relat Res 438:123-7. 2005....
- Morphological and immunophenotypic features of primary and metastatic giant cell tumour of boneM Alberghini
Istituto Ortopedico Rizzoli, Bologna, Italy
Virchows Arch 456:97-103. 2010..Our findings suggest that most lung nodules associated with primary conventional GCTBs are implants derived from tumour emboli formed in areas of haemorrhage and thrombus formation within the primary tumour...
- Histologically verified lung metastases in benign giant cell tumours--14 cases from a single institutionM Dominkus
University Clinic of Vienna, Department of Orthopaedics, Allgemeines Krankenhaus der Stadt Wien, Vienna, Austria
Int Orthop 30:499-504. 2006..We conclude that even metastatic benign giant cell tumours have an excellent prognosis after adequate resection. No prognostic factors despite high-grade lesions were detectable...
- CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expressionPatrick Kwok Shing Ng
School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR
J Cell Biochem 110:438-46. 2010....
- Histogenetic characterization of giant cell tumor of boneManuela Salerno
Laboratory for Pathophysiology, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
Clin Orthop Relat Res 466:2081-91. 2008..The increased number of giant cells in GCT may be secondary to an autocrine circuit mediated by the receptor activator of nuclear factor kB...
- Functional outcome of en bloc excision and osteoarticular allograft replacement with the Sauve-Kapandji procedure for Campanacci grade 3 giant-cell tumor of the distal radiusRobert M Szabo
Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, 95817, USA
J Hand Surg Am 31:1340-8. 2006..The purpose of this study was to assess with validated patient outcome surveys the intermediate to long-term outcomes of all patients treated with this surgery and to analyze their functional results and document tumor control...
- Treatment options for recurrent giant cell tumors of boneMaurice Balke
Department of Orthopedic Surgery, University of Muenster, Albert Schweitzer Str 33, 48149, Munster, Germany
J Cancer Res Clin Oncol 135:149-58. 2009..The possible surgical procedures range from repeated intralesional curettage to wide resection...
- Giant cell tumor of bone: treatment and outcome of 214 casesMaurice Balke
Department of Orthopedic Surgery, University of Muenster, Muenster, Germany
J Cancer Res Clin Oncol 134:969-78. 2008Two hundred and fourteen patients with benign giant cell tumor of bone (GCTB), treated from 1980 to 2007 at the Department of Orthopedics of the University of Muenster (Germany), were analyzed in a retrospective study.
- Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cellsUkei Anazawa
Department of Orthopaedic Surgery, Keio University, School of Medicine, Tokyo, Japan
Ultrastruct Pathol 30:151-8. 2006..investigated ultrastructural cytochemical features of multinucleated and mononuclear stromal cells in giant cell tumor of bone (GCTB), giant cell tumor of tendon sheath (GCTTS), and pigmented villonodular synovitis (PVNS)...
- Techniques in the management of juxta-articular aggressive and recurrent giant cell tumors around the kneeS Vidyadhara
Department of Orthopaedics, Kasturba Medical College, Manipal, Udupi, Karnataka 576 104, India
Eur J Surg Oncol 33:243-51. 2007..Juxta-articular aggressive and recurrent giant cell tumors around the knee pose difficulties in management. This article reviews current problems and options in the management of these giant cell tumors...
- Metastatic giant cell tumor of bone: are there associated factors and best treatment modalities?Seethalakshmi Viswanathan
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai 400012, India
Clin Orthop Relat Res 468:827-33. 2010..None of the patients died of their metastatic disease. None of the risk factors we studied was associated with metastasis in giant cell tumors. Although the overall outcome was favorable, metastasectomy is recommended where feasible...
- Impact severity of local recurrence in giant cell tumor of boneRichard L McGough
From the University of Texas M D Anderson Cancer Center, Department of Orthopaedic Oncology, Houston, TX
Clin Orthop Relat Res 438:116-22. 2005..Despite its benign histology, giant cell tumor of bone is an aggressive tumor that demands meticulous attention to surgical detail and close postoperative ..
- Giant cell tumour of boneDavid M Thomas
Departments of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Curr Opin Oncol 21:338-44. 2009..Giant cell tumour of bone (GCT) is the most common benign bone tumour and afflicts a young population. Treatment options for patients with unresectable disease have remained fairly static for the past three decades...
- Giant cell tumour of the sacrum: a suggested algorithm for treatmentRajkumar Thangaraj
The Royal Orthopaedic Hospital Oncology Service, Bristol Road South, Birmingham, B31 2AP, UK
Eur Spine J 19:1189-94. 2010..Embolisation and curettage are the preferred first option with radiotherapy as a possible adjunct. Spinopelvic fusion may be needed when the sacrum collapses...
- Features of grade 3 giant cell tumors of the distal radius associated with successful intralesional treatmentLana Kang
Department of Orthopaedics, Division of Hand and Upper Extremity, Hospital for Special Surgery, 523 East 72nd Street, New York, NY 10021, USA
J Hand Surg Am 35:1850-7. 2010..The goal of this study was to identify radiographic and anatomic features of Campanacci grade 3 distal radius giant cell tumors that are associated with an acceptable rate of local recurrence after intralesional treatment...
- Clonality studies in giant cell tumor of boneH S Schwartz
Vanderbilt University, Department of Orthopaedics and Rehabilitation, Nashville, Tennessee 37232 2550, USA
J Orthop Res 20:387-90. 2002..Seventeen female patients with giant cell tumor of bone had their DNA harvested and their X-chromosome inactivation pattern and polymorphisms determined and ..
- [Factors related to biologic behavior in giant cell tumor of bone]Xiang Ying Ran
Department of Pathology, Shanghai Jiaotong University Affiliated the Sixth People s Hospital, Shanghai 200233, China
Zhonghua Bing Li Xue Za Zhi 42:669-74. 2013..To study the histogenesis of giant cell tumor (GCT) and factors related to tumor recurrence, invasiveness and malignant transformation...
- Long-term outcome of giant cell tumors of bone around the knee treated by en bloc resection of tumor and reconstruction with prosthesisXiu Chun Yu
Department of Orthopaedics, The General Hospital of Jinan Military Commanding Region, Jinan, China
Orthop Surg 2:211-7. 2010..To study the long-term outcomes and complications of giant cell tumors around the knee treated with en bloc resection and reconstruction with prosthesis...
- Giant cell tumor of bone: are we stratifying results appropriately?Thomas J Kremen
Department of Orthopaedic Surgery, University of California Los Angeles Medical Center, Box 956902, 76 143 CHS, Los Angeles, CA, USA
Clin Orthop Relat Res 470:677-83. 2012There is no consensus as to which surgical approach to the treatment of giant cell tumor of bone is most appropriate or which patients are at a higher risk for recurrence or metastasis.
- RANKL, denosumab, and giant cell tumor of boneDavid M Thomas
Department of Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, Victoria, Australia
Curr Opin Oncol 24:397-403. 2012..Giant cell tumor (GCT) of bone is a benign, osteolytic neoplasm of bone. The receptor activator of NF-KB ligand (RANKL) pathway has recently been shown to play a key role in the pathogenesis of GCT...
- Stro-1(+) stromal cells have stem-like features in giant cell tumor of boneJie Lan
Department of Orthopaedics, Peking University Third Hospital, Beijing, People s Republic of China
J Surg Oncol 106:826-36. 2012b>Giant cell tumor of bone (GCTB) is an aggressive benign bone tumor with poor prognosis whose neoplastic component is stromal cells (SCs). Tumor stem-like cells (TSCs) have been demonstrated as precursors for tumor genesis and growth...
- MicroRNA expression profiles in metastatic and non-metastatic giant cell tumor of boneNeda Mosakhani
Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Histol Histopathol 28:671-8. 2013b>Giant cell tumor of bone (GCTB) is a skeletal neoplasm, a locally aggressive tumor that occasionally metastasizes to the lungs...
- p63 expression in giant cell-containing lesions of bone and soft tissueGustavo de la Roza
Department of Pathology, Upstate University Hospital, Syracuse, New York, USA
Arch Pathol Lab Med 135:776-9. 2011..Although routine histology is often all that is required to diagnose giant cell tumor of bone, immunohistochemistry could prove useful to distinguish it from other benign and malignant giant cell-..
- The efficacy of chemical adjuvants on giant-cell tumour of bone. An in vitro studyY Gortzak
Mount Sinai Hospital, Toronto, Canada
J Bone Joint Surg Br 92:1475-9. 2010..No multinucleated cell formation was seen in these cultures. These results suggest that the use of chemical adjuvants other than water could help improve local control in the treatment of GCT of bone...
- Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of boneV H Rao
Meyer Rehabilitation Institute and Department of Pediatrics, University of Nebraska Medical Center, Omaha 68198, USA
Clin Exp Metastasis 15:400-9. 1997..This suggests that multinucleated giant cells in primary cultures secrete a factor(s) that stimulates stromal cells to produce MMP-9, which, in turn, may contribute to the aggressive behavior of GCT...
- Expression of bone morphogenetic proteins in giant cell tumor of boneNaoko Kudo
Division of Orthopedic Surgery, Department of Regenerative Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Niigata 951 8510, Japan
Anticancer Res 29:2219-25. 2009..Although the bone formation in GCT in supposedly due to bone morphogenetic proteins (BMPs), the expression pattern of BMPs in GCT has not been well investigated...
- Argon beam coagulation as an adjuvant for local control of giant cell tumorValerae O Lewis
MD Anderson Cancer Center, Houston, TX, USA
Clin Orthop Relat Res 454:192-7. 2007..These data suggest argon beam coagulation as an adjuvant therapy is associated with in a low rate of local recurrence and is a reasonable adjuvant treatment option...
- Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone?C L Gaston
Royal Orthopaedic Hospital NHS Foundation Trust, Bristol Road South, Northfield, Birmingham B31 2AP, UK
J Bone Joint Surg Br 93:1665-9. 2011..001). In patients who developed local recurrence, 75.0% (9 of 12) of those with previous cementation required a joint replacement, compared with 45.2% (33 of 73) of those without cement (p = 0.044)...
- Histological and clinical characteristics of malignant giant cell tumor of boneLihua Gong
Department of Pathology, Beijing Jishuitan Hospital, Fourth Medical College of Peking University, Teaching Hospital of Tsinghua University, 31 Xinjiekou East Street, Xicheng District, Beijing 100035, China
Virchows Arch 460:327-34. 2012..Five cases were primary malignant giant cell tumor of bone (PMGCTB), and 12 cases were giant cell tumors of bone initially diagnosed as benign but malignant in a ..
- PTHrP increases RANKL expression by stromal cells from giant cell tumor of boneRobert W Cowan
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
J Orthop Res 30:877-84. 2012b>Giant cell tumor of bone (GCT) presents with numerous osteoclast-like multinucleated giant cells that are principally responsible for the extensive bone resorption by the tumor...
- Metastasis of giant cell tumor to the breast: case report and review of the literatureAhmet Alacacioglu
Institute of Oncology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
Tumori 92:351-3. 2006....
- [Giant cell tumor at the wrist: a review of 23 cases]Tackin Ozalp
Celal Bayar Universitesi Tip Fakültesi Ortopedi ve Travmatoloji Anabilim Dali
Acta Orthop Traumatol Turc 40:144-50. 2006....
- Ethanol as a local adjuvant for giant cell tumor of boneKevin B Jones
Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 01051 John Pappajohn Pavilion, Iowa City, IA 52242, USA
Iowa Orthop J 26:69-76. 2006..Until such evidence becomes available, the use of adjuvant ethanol offers a compromise between higher toxicity adjuvants and no chemical adjuvant at all...
- Giant cell tumour of bone: morphological, biological and histogenetical aspectsMathias Werner
Institute of Osteopathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Int Orthop 30:484-9. 2006..Further research of the pathogenesis of GCT as well as the complex interactions of its cellular populations may provide the knowledge necessary for developing approaches for a biological-based therapy of this neoplasm...
- Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of boneY Y Cheng
Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR
Calcif Tissue Int 75:71-7. 2004..41% at 150 microM, followed by pamidronate (22.23%) and alendronate (15.3%). Our observations suggest that these drugs may be considered as potential adjuvants in the treatment of GCT...
- Hip joint remodeling in an adult following excision of a giant cell tumor involving the acetabulum: a case report and literature reviewHideji Nishida
Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
Arch Orthop Trauma Surg 126:458-63. 2006We describe a 47-year-old man with a giant cell tumor of bone involving the acetabulum treated with curettage and bone grafting which resulted in good remodeling of the hip joint...
- [Clinicopathologic study of giant cell angioblastoma]Rong Jun Mao
Department of Pathology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan 528000, China
Zhonghua Bing Li Xue Za Zhi 39:752-6. 2010..to study the clinicopathological features, imaging characteristics, immunophenotypes and differential diagnosis of giant cell angioblastoma (GCAB)...
- Giant cell tumor of bone with pulmonary metastasesYasuhiro Okamoto
Med Pediatr Oncol 41:454-9. 2003
- Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of boneCarol P Y Lau
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Room 74034 5 F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong
J Orthop Res 29:403-13. 2011..Our findings support that the combination of bisphosphonates with GGTIs or FTIs with GGTIs may be used as potential adjuvants in the treatment of GCT of bone...
- Soft tissue extension increases the risk of local recurrence after curettage with adjuvants for giant-cell tumor of the long bonesL van der Heijden
Department of Orthopaedic Surgery, Leiden University Medical Center, The Netherlands
Acta Orthop 83:401-5. 2012..The aim of the study was the identification of individual risk factors after curettage with adjuvants in GCTB...
- Differentially expressed genes in giant cell tumor of boneErica Babeto
Laboratory of Genomics Studies, Sao Paulo State University UNESP, Cristóvão Colombo, 2265, 15054 000, Sao Jose do Rio Preto, SP, Brazil
Virchows Arch 458:467-76. 2011....
- Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatmentMarta Karpik
Department of Clinical Orthopaedics and Traumatology, Medical University Hospital in Białystok
Ortop Traumatol Rehabil 12:207-15. 2010..b>Giant Cell Tumor of Bone accounts for 4-8% of primary bone tumors. It is most commonly seen in women aged 20 to 40 years...
- The role of TWIST as a regulator in giant cell tumor of boneShalini Singh
Department of Surgery, McMaster University, Hamilton, Ontario, Canada
J Cell Biochem 112:2287-95. 2011b>Giant cell tumor of bone (GCT) is an aggressive tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells...
- Interferon alfa-2b for recurrent and metastatic giant cell tumor of the spine: report of two casesFeng Wei
Department of Orthopedics, Peking University Third Hospital, Beijing, China
Spine (Phila Pa 1976) 35:E1418-22. 2010..Case report...
- Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of boneTed S Liao
Center for Orthopaedic Research, Department of Orthopaedic Surgery, Columbia University, 622 W 168th Street, BHN816, New York, NY 10032, USA
J Orthop Res 23:203-9. 2005..These results suggest that SDF-1 is one of the significant chemoattractant factors involved in the recruitment of hematopoietic osteoclast precursor cells during tumor-induced osteoclastogenesis...
- Giant cell tumor of the sternum: a case report and review of the literatureHiroyuki Futani
Department of Orthopaedic Surgery, Hyogo College of Medicine, 1 1 Mukogawa Nishinomiya, Hyogo 663 8501, Japan
Anticancer Res 28:4117-20. 2008..The initial treatment should be extended curettage followed by filling with PMMA...
- Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control studyLung Fung Tse
Department of Orthopaedics and Traumatology, Prince of Wales Hospital, Shatin, Hong Kong
Bone 42:68-73. 2008..Therefore our clinical study aims to investigate whether the administration of bisphosphonate as an adjuvant can further decrease local recurrence following the surgical treatment of GCT of bone...
- Bisphosphonate treatment of aggressive primary, recurrent and metastatic Giant Cell Tumour of BoneMaurice Balke
Department of Orthopaedic Surgery, University of Munster, Munster, Germany
BMC Cancer 10:462. 2010..GCTB frequently recurs and can produce metastatic lesions in the lungs. Bisphosphonates are anti-resorptive drugs which act mainly on osteoclasts...
- Giant cell tumor of boneWilliam M Mendenhall
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
Am J Clin Oncol 29:96-9. 2006..To discuss the treatment and outcomes for giant cell tumor (GCT) of bone...
- Giant cell tumor of bone: risk factors for recurrenceFrank M Klenke
Department of Orthopedic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Clin Orthop Relat Res 469:591-9. 2011Many surgeons treat giant cell tumor of bone (GCT) with intralesional curettage. Wide resection is reserved for extensive bone destruction where joint preservation is impossible or when expendable sites (eg, fibular head) are affected...
- Giant-cell tumors of bone: an analysis of 87 casesYu Ping Su
Department of Orthopaedics and Traumatology, Veterans General Hospital, 201, Sec 2, Shih Pai Road, 112, Taipei, Taiwan, ROC
Int Orthop 28:239-43. 2004..Functional outcome was evaluated using the Enneking scoring system. Average rating was 86% for the lower extremity and 83% for the upper extremity. The overall satisfactory rate was 88%...
- Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaBTeresa Morgan
Ian Potter Foundation Center for Cancer Genomics and Predictive Medicine and Research Division, Peter MacCallum Cancer Center, Melbourne, Australia
Am J Pathol 167:117-28. 2005b>Giant cell tumor of bone (GCT) is a generally benign, osteolytic neoplasm comprising stromal cells and osteoclast-like giant cells...
- Antiangiogenic therapy with interferon alpha for giant cell lesions of the jawsLeonard B Kaban
Walter C Guralnick Professor and Chairman, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston 02114, USA
J Oral Maxillofac Surg 60:1103-11; discussion 1111-3. 2002..The purpose of this report is to present a treatment protocol consisting of enucleation, with preservation of vital structures, followed by subcutaneous interferon alpha...
- Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the boneCheng Han Lee
Department of Pathology, Stanford University, Stanford, CA, USA
Mod Pathol 21:531-9. 2008..These findings altogether show that p63 can be used as a diagnostic marker to aid the clinical diagnosis of GCTOB...
- What's new in musculoskeletal oncologyValerae O Lewis
MD Anderson Cancer Center, P O Box 301402, Unit 408, Houston, TX 77230 1402, USA
J Bone Joint Surg Am 89:1399-407. 2007
- From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlationM D Murphey
Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Rm M 133A, Washington, DC 20306, USA
Radiographics 21:1283-309. 2001..Recognition of the spectrum of radiologic appearances of GCT and GCRG is important in allowing prospective diagnosis, guiding therapy, and facilitating early detection of recurrence...
- Joint salvage for pathologic fracture of giant cell tumor of the lower extremityBenjamin M Deheshi
University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
Clin Orthop Relat Res 459:96-104. 2007..Joint salvage for patients with pathologic fractures through giant cell tumor of weightbearing bones is a reasonable option with functional outcomes and recurrence rates comparable to those of patients without fracture...
- Reconstruction of the distal radius by fibula following excision of giant cell tumorV K Aithal
Department of Orthopedics, Nizwa Hospital, P O Box 1222, Sultanate of Oman
Int Orthop 27:110-3. 2003..2 months. The surgical technique using a radiofibular plate and K wire through the wrist had a low nonunion rate, no graft related complications, good range of movement, and good hand functions...
- Giant-cell tumour of boneM Szendroi
Department of Orthopaedics, Semmelweis University, Budapest, Hungary
J Bone Joint Surg Br 86:5-12. 2004
- Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty casesBenjamin Hoch
Mayo Clinic, Rochester, MN 55905, USA
J Bone Joint Surg Am 88:1998-2008. 2006b>Giant cell tumor of bone accounts for 4% to 5% of primary bone tumors. Approximately 1% of cases present as multiple synchronous or metachronous lesions...
- [Giant cell tumor of bone. An evaluation of 87 patients]P U Tunn
Klinik fur Chirurgie und Chirurgische Onkologie, Charite Universitatsmedizin Berlin
Z Orthop Ihre Grenzgeb 141:690-8. 2003..Giant cell tumor (GCT) of bone is a very peculiar and interesting tumor due to of its biological behavior and the phenomenon of pulmonary metastases of a histologically benign tumor. We present the results of a retrospective study...
- Megavoltage radiation therapy for axial and inoperable giant-cell tumor of boneA Chakravarti
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Bone Joint Surg Am 81:1566-73. 1999..We performed the present study to evaluate the efficacy of megavoltage radiation in terms of lack of tumor progression and treatment-related morbidity...
- Local control of long bone giant cell tumour using curettage, burring and bone grafting without adjuvant therapyF Malek
San Francisco Department of Orthopaedic Surgery UCSF Comprehensive Cancer Center Orthopaedic Oncology Service, University of California, San Francisco, CA 94115 1939, USA
Int Orthop 30:495-8. 2006..In cases where more resources are available, the addition of adjuvant therapies, as noted in the recent literature, may be beneficial. The results of this study should be considered when designing multicenteric studies in the future...
- Cytochemical and ultrastructural changes in the osteoclast-like giant cells of giant cell tumor of bone following bisphosphonate administrationYuen Y Cheng
Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong, China
Ultrastruct Pathol 27:385-91. 2003b>Giant cell tumor of bone (GCT) is a local aggressive neoplasm of bone characterized by expansive osteolytic lesions at the epiphysis of long bones...
- Radiotherapy in the management of giant cell tumor of boneJimmy J Caudell
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 57:158-65. 2003To evaluate the outcomes of patients with giant cell tumor of bone (GCTB) treated with radiotherapy (RT) with or without surgical resection.
- Multicentric giant cell tumor of bone: ten lesions at presentationIl Hyung Park
Department of Orthopaedic Surgery, Kyungpook National University Hospital, 50 Samduk, Chung gu, 700 721 Taegu, Korea South
Skeletal Radiol 32:526-9. 2003The case of a 19-year-old man with multicentric and subsequent metachronous giant cell tumor of bone is presented. Ten lesions were identified at presentation and eventually two more lesions developed...
- Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesionsS M Kumta
Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T Hongkong, China
Life Sci 73:1427-36. 2003..the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in giant cell tumor of bone (GCT) and other osteolytic lesions in bone...
- Giant cell tumor of bone: an immunohistochemical comparative studyF Masui
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
Pathol Int 48:355-61. 1998....
- Giant cell tumor of bone: a clinicopathologic study of prognostic factorsF Masui
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
Pathol Int 48:723-9. 1998Forty-seven cases of giant cell tumor of bone were clinicopathologically reviewed to determine any useful prognostic factors. Disease recurred in 11 cases...
- Malignancy in giant cell tumor of boneFranco Bertoni
Istituto Ortopedico Rizzoli, Bologna, Italy
Cancer 97:2520-9. 2003..The goals of the current study were to define the clinicopathologic and histologic features of malignancy in giant cell tumors and to clarify the terminology...
- Cement is recommended in intralesional surgery of giant cell tumors: a Scandinavian Sarcoma Group study of 294 patients followed for a median time of 5 yearsAarne H Kivioja
Department of Orthopedics and Traumatology, Helsinki University Central Hospital, Helsinki, Finland
Acta Orthop 79:86-93. 2008..Giant cell tumors of bone rarely metastasize but often recur locally after surgery. There is limited knowledge about the risk of recurrence related to different types of treatment...
- Complications associated with bone cementing for the treatment of giant cell tumors of boneTakuro Wada
Department of Orthopaedic Surgery, Sapporo Medical University, South 1, West 16, Sapporo 060 8543, Japan
J Orthop Sci 7:194-8. 2002..Acrylic cement reconstruction is a safe and effective procedure that provides local adjuvant therapy. Giant cell tumors with an associated intraarticular fracture remain a challenging problem to treat...
- RANK-Associated Inhibitor (RAIN) in Osteoclast FormationBryant Darnay; Fiscal Year: 2007..and have been implicated in various diseases, which include rheumatoid arthritis, osteoporosis, giant cell tumor of bone, Paget's disease, metastatic breast cancer, multiple myeloma, and familial expansile osteolysis...
- ANALYSIS OF HYPERTHERMIA OF GIANT CELL TUMORS OF BONEDavid Nelson; Fiscal Year: 1991..This will simulate the thermal effects of acrylic cementation following curettage of a giant cell tumor of bone. The procedure has been shown to result in a lower rate of tumor recurrence than is seen with curettage ..
- METABOLISM IN NORMAL AND OSTEOARTHRITIC CARTILAGEHenry Mankin; Fiscal Year: 2001..It is further speculated that the study of serine proteinases produced by OA cartilage may have strong implications for the management of this debilitating disease. ..
- INVESTIGATING THE MECHANISMS OF PRB TUMOR SUPPRESSIONArnab Chakravarti; Fiscal Year: 2003..Specific Aim number 3: To determine whether the deregulation of E2F dependent transcription is correlated with the tumorigenic potential of RB -/- cells in-vivo. ..
- Minimally Invasive Approaches for Craniofacial SurgeryMaria Troulis; Fiscal Year: 2005..abstract_text> ..
- Molecular Mechanisms of Ectopic Bone FormationSTEVEN LIETMAN; Fiscal Year: 2006..abstract_text> ..
- Bioengineering Annulus Fibrosus using Silk ScaffoldRita Kandel; Fiscal Year: 2006..The viability and mechanical properties of the tissue will be evaluated. ..