osteochondroma

Summary

Summary: A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.

Top Publications

  1. ncbi Osteochondroma causing diaphragmatic rupture and bowel obstruction in a 14-year-old boy
    Fizan Abdullah
    Division of Pediatric General and Orthopedic Surgery, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA, 90027, USA
    Pediatr Surg Int 22:401-3. 2006
  2. ncbi Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas
    L Hameetman
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 211:399-409. 2007
  3. ncbi Osteochondroma after total body irradiation: an age-related complication
    Jonathan Taitz
    Centre for Children s Cancer and Blood Disorders, Sydney Children s Hospital, Randwick, Australia
    Pediatr Blood Cancer 42:225-9. 2004
  4. ncbi Expression of collagen type I, II, X and Ki-67 in osteochondroma compared to human growth plate cartilage
    K Huch
    Department of Orthopaedic Surgery, University of Ulm, Germany
    Eur J Histochem 46:249-58. 2002
  5. ncbi Parosteal lipoma associated with an underlying osteochondroma arising from the hallux
    Eugene T H Ek
    Department of Orthopaedics, University of Melbourne, St Vincent s Hospital, P O Box 2900, Fitzroy, Melbourne, Victoria, Australia
    Skeletal Radiol 36:689-92. 2007
  6. doi Primary cilia organization reflects polarity in the growth plate and implies loss of polarity and mosaicism in osteochondroma
    Carlos E de Andrea
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Lab Invest 90:1091-101. 2010
  7. ncbi Arthroscopic resection of an osteochondroma of the knee
    S Schmoyer
    Sports Medicine Center of Metro Detroit, Troy, Michigan
    Arthroscopy 17:765-7. 2001
  8. doi Posttraumatic popliteal pseudoaneurysm caused by a femoral osteochondroma
    Martin Rupprecht
    Department of Trauma, Hand and Reconstructive Surgery, University Hamburg, Hamburg, Germany
    J Pediatr Orthop B 19:341-3. 2010
  9. ncbi Osteochondroma of the coronoid process
    Julio Villanueva
    Servicio de Cirugía Maxilo Facial, Hospital Clinico San Borja Arriaran
    Med Oral Patol Oral Cir Bucal 11:E289-91. 2006
  10. ncbi Solitary thoracic osteochondroma: case report and review of the literature
    Priscilla Brastianos
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neurosurgery 56:E1379; discussion E1379. 2005

Research Grants

Detail Information

Publications227 found, 100 shown here

  1. ncbi Osteochondroma causing diaphragmatic rupture and bowel obstruction in a 14-year-old boy
    Fizan Abdullah
    Division of Pediatric General and Orthopedic Surgery, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA, 90027, USA
    Pediatr Surg Int 22:401-3. 2006
    Exostosis, also known as osteochondroma, results from a disorder of the growth-plate where bone grows away from the growth axis and forms an irregular projection...
  2. ncbi Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas
    L Hameetman
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 211:399-409. 2007
    ..We hypothesize that loss of EXT expression disrupts the function of the EXT1/2 complex in HSPG biosynthesis, resulting in the intracellular accumulation of HSPG core proteins that we found in these tumours...
  3. ncbi Osteochondroma after total body irradiation: an age-related complication
    Jonathan Taitz
    Centre for Children s Cancer and Blood Disorders, Sydney Children s Hospital, Randwick, Australia
    Pediatr Blood Cancer 42:225-9. 2004
    The discovery of a mass lesion in a long-term cancer survivor causes significant anxiety. The causes of such a mass include benign osteochondroma, which has been reported following focal irradiation and total body irradiation (TBI).
  4. ncbi Expression of collagen type I, II, X and Ki-67 in osteochondroma compared to human growth plate cartilage
    K Huch
    Department of Orthopaedic Surgery, University of Ulm, Germany
    Eur J Histochem 46:249-58. 2002
    ....
  5. ncbi Parosteal lipoma associated with an underlying osteochondroma arising from the hallux
    Eugene T H Ek
    Department of Orthopaedics, University of Melbourne, St Vincent s Hospital, P O Box 2900, Fitzroy, Melbourne, Victoria, Australia
    Skeletal Radiol 36:689-92. 2007
    ..There have been no reported cases of such lesions arising in the foot. Hence, we report the first case of a parosteal lipoma arising in the great toe in association with an underlying osteochondroma.
  6. doi Primary cilia organization reflects polarity in the growth plate and implies loss of polarity and mosaicism in osteochondroma
    Carlos E de Andrea
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Lab Invest 90:1091-101. 2010
    ..and bone growth, little is known about the organization of primary cilia in the growth plate cartilage and osteochondroma. Osteochondromas are bone tumors formed along the growth plate, and they are caused by mutations in EXT1 or ..
  7. ncbi Arthroscopic resection of an osteochondroma of the knee
    S Schmoyer
    Sports Medicine Center of Metro Detroit, Troy, Michigan
    Arthroscopy 17:765-7. 2001
    We present a case of arthroscopic resection of a symptomatic periarticular osteochondroma of the knee...
  8. doi Posttraumatic popliteal pseudoaneurysm caused by a femoral osteochondroma
    Martin Rupprecht
    Department of Trauma, Hand and Reconstructive Surgery, University Hamburg, Hamburg, Germany
    J Pediatr Orthop B 19:341-3. 2010
    We report an exceptional case of a 12-year-old-boy with a pseudoaneurysm of the popliteal artery caused by an osteochondroma on the lower femoral metaphysic after a hyperextension trauma...
  9. ncbi Osteochondroma of the coronoid process
    Julio Villanueva
    Servicio de Cirugía Maxilo Facial, Hospital Clinico San Borja Arriaran
    Med Oral Patol Oral Cir Bucal 11:E289-91. 2006
    b>Osteochondroma is the most common benign neoplasia of the skeleton. In the head it was been described in cranial base, posterior maxillary surface, maxillary sinus, and different mandibular areas like condyle, ramus, body and symphysis...
  10. ncbi Solitary thoracic osteochondroma: case report and review of the literature
    Priscilla Brastianos
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neurosurgery 56:E1379; discussion E1379. 2005
    ..We report a case of a thoracic solitary osteochondroma arising from within the vertebral body, review the cases reported in the literature, and propose ..
  11. ncbi A rare case of solitary osteochondroma of the dens of the C2 vertebra
    E Chatzidakis
    Department of Neurosurgery, General Hospital of Nikea Piraeus, Agios Panteleimon, Greece
    Acta Neurochir (Wien) 149:637-8. 2007
    We report an extremely rare case of a 22-year-old man with an asymptomatic osteochondroma of the dens of C2 vertebra accidentally found during a brain CT scan examination.
  12. ncbi Osteochondroma of the sella turcica presenting with intratumoral hemorrhage
    Tomoo Inoue
    Department of Neurosurgery, Aomori Prefectural Central Hospital, Aomori, Japan
    Neurol Med Chir (Tokyo) 49:37-41. 2009
    A 29-year-old man presented with a primary sellar turcica osteochondroma manifesting as intratumoral hemorrhage mimicking pituitary apoplexy. The patient suffered sudden onset of headache concomitant with vision loss in the left eye...
  13. ncbi Osteochondroma in the lumbar intraspinal canal causing nerve root compression
    Jun Xu
    Department of Orthopedics, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China
    Orthopedics 32:133. 2009
    ..Postoperative histopathologic examination confirmed our hypothesis of benign osteochondroma. Postoperatively, the patient recovered rapidly in neurological function and was free of symptoms...
  14. ncbi Scapular osteochondroma with reactive bursitis presenting as a chest wall tumour
    M J Shackcloth
    The Cardiothoracic Centre, Thomas Drive, L14 3PE, Liverpool, UK
    Eur J Cardiothorac Surg 18:495-6. 2000
    ..The mass and exostosis were resected resulting in complete resolution of symptoms. Histological examination showed the mass to be a reactive bursa, with no evidence of neoplasia...
  15. doi Cartilage tumours and bone development: molecular pathology and possible therapeutic targets
    Judith V M G Bovee
    Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Nat Rev Cancer 10:481-8. 2010
    ....
  16. pmc Extra-osseous osteochondroma-like soft tissue mass of the patello-femoral space
    Francesco Oliva
    Department of Orthopaedics and Traumatology, University of Rome Tor Vergata School of Medicine, Viale Oxford 81, Rome, Italy
    BMC Musculoskelet Disord 7:57. 2006
    ..Extraskeletal cartilaginous tumors are uncommon. Osteochondromas usually arise from the metaphyseal region of the growing skeleton...
  17. doi Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage
    Carlos E de Andrea
    Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
    J Pathol 224:160-8. 2011
    ..Impaired biosynthesis of heparan sulphate glycosaminoglycans causes osteochondroma, the most common bone tumour to occur during adolescence...
  18. ncbi Spinal osteochondromas in middle-aged to elderly patients
    Daisuke Sakai
    Department of Orthopaedic Surgery, Functional Reconstruction, Tokai University School of Medicine, Kanagawa, Japan
    Spine (Phila Pa 1976) 27:E503-6. 2002
    ..Three case reports of solitary spinal osteochondromas in middle-aged and elderly patients...
  19. ncbi Costal osteochondroma. A rare cause of spinal cord compression
    W M Tang
    Department of Orthopaedic Surgery, University of Hong Kong, Duchess of Kent Hospital, China
    Spine (Phila Pa 1976) 23:1900-3. 1998
    STUDY DESIGN: Report of a rare cause of spinal cord compression: costal osteochondroma. OBJECTIVE: To describe a very rare cause of spinal cord compression, costal osteochondroma, which was present in a 16-year-old girl with a history of ..
  20. doi Symptomatic osteochondroma of the spine in elderly patients. Report of 3 cases
    Mitsuru Yagi
    Department of Orthopedic Surgery, Kawasaki Municipal Hospital, Kawasaki City, Japan
    J Neurosurg Spine 11:64-70. 2009
    Whereas osteochondroma is a common benign bone tumor in adolescence, it is rarely observed in elderly patients. It is unknown why osteochondromas, which usually develop during skeletal growth, rarely develop in elderly patients...
  21. ncbi Solitary intraspinal lumbar vertebral osteochondroma: a case report
    Doga Gurkanlar
    Social Security Institution Ankara Training Hospital, I Neurosurgery Clinic
    J Clin Neurosci 11:911-3. 2004
    ..b>Osteochondroma should be considered while evaluating a patient with low back pain or radiculopathy without a CT or MRI ..
  22. ncbi Osteochondroma of the spine: an enigmatic tumor of the spinal cord. A series of 10 cases
    M C Sharma
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
    J Neurosurg Sci 46:66-70; discussion 70. 2002
    ..Osteochondro-mas are common benign bony lesions of long bones but involvement of spine by solitary osteochondroma and its presentation as compressive myelopathy is rare. Most of the literature is in the form of case reports.
  23. ncbi Differential diagnosis of tumours and tumour-like lesions of the infrapatellar (Hoffa's) fat pad: pictorial review with an emphasis on MR imaging
    C Helpert
    Department of Radiology, MRI Centre, Royal Orthopaedic Hospital, Birmingham B31 2AP, UK
    Eur Radiol 14:2337-46. 2004
    ..This pictorial review illustrates the spectrum of mass-like lesions that can affect the IFP, emphasizing the radiographic and MR findings that suggest a specific diagnosis...
  24. doi Neurological manifestations, imaging characteristics, and surgical outcome of intraspinal osteochondroma
    Iraj Lotfinia
    Department of Neurosurgery, Shohada Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
    J Neurosurg Spine 12:474-89. 2010
    ..Concurrent spinal cord compression is a very rare entity. The purpose of this study was to evaluate the authors' 10-year experience with the imaging characteristics and surgical outcome in patients with symptomatic spinal OC...
  25. ncbi The solitary intraspinal vertebral osteochondroma. An unusual cause of compressive myelopathy: features and literature review
    A Khosla
    Department of Radiology, St Louis University Health Sciences Center, Missouri, USA
    Spine (Phila Pa 1976) 24:77-81. 1999
    ..OBJECTIVES: To evaluate the clinical presentation and radiographic findings of patients with intraspinal osteochondroma with compressive myelopathy and to review the relevant English-language medical literature...
  26. pmc Para-articular chondroma and osteochondroma of the infrapatellar fat pad: a report of three cases
    H Sakai
    Department of Orthopaedic Surgery, Dokkyo University School of Medicine, Tochigi, Japan
    Int Orthop 23:114-7. 1999
    We report three cases of para-articular chondroma and osteochondroma in the region of infrapatellar fat pad. All three lesions were resected and examined histologically...
  27. ncbi Osteochondroma of the thoracic spine and scoliosis
    M José Alcaraz Mexía
    Servicio de Radiologia, Hospital Universitario de Getafe, Madrid, Spain
    Spine (Phila Pa 1976) 26:1082-5. 2001
    The case of a 16-year-old patient with an osteochondroma in T11 and scoliosis is reported.
  28. ncbi Extraskeletal osteochondroma of the foot
    Jordan S Sheff
    Private Practice, Newport, RI 02840, USA
    J Foot Ankle Surg 44:57-9. 2005
    An extraskeletal osteochondroma is an infrequently encountered benign cartilaginous tumor with a predilection for the hands and feet that usually does not exceed 3 cm in diameter...
  29. ncbi A giant extrasynovial osteochondroma in the infrapatellar fat pad: end stage Hoffa's disease
    Egemen Turhan
    Department of Orthopaedics and Traumatology, Zonguldak Karaelmas University School of Medicine, Esenkoy, Kozlu, Zonguldak, Turkey
    Arch Orthop Trauma Surg 128:515-9. 2008
    ..The osteochondroma of the infrapatellar fat pad secondary to the Hoffa's disease can be more problematic...
  30. ncbi Extraskeletal osteochondroma in the nape of the neck: a case report
    R Singh
    Department of Orthopaedic Surgery, Pt BD Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India
    J Orthop Surg (Hong Kong) 14:192-5. 2006
    Extraskeletal osteochondroma in the nape of the neck is rare and its pathological diagnosis is based on radiological and histopathological examination...
  31. doi Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningioma
    Hilary L Somerset
    Department of Pathology, The University of Colorado Health Sciences Center, Aurora, CO, USA
    J Neurooncol 98:421-6. 2010
    ..The mass was resected en bloc. Extensive histological sectioning revealed a benign osteochondroma predominantly composed of lobules of hypocellular cartilage...
  32. ncbi Para-articular osteochondroma of the knee
    Giacomo Rizzello
    Department of Orthopaedics, University Campus Bio Medico, Rome, Italy
    Arthroscopy 23:910.e1-4. 2007
    ..Patients with these lesions are currently treated with the use of marginal resection or excision...
  33. pmc EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas
    J V Bovée
    Departments of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Hum Genet 65:689-98. 1999
    ..Approximately 15% of all chondrosarcomas arise within the cartilaginous cap of an osteochondroma. EXT is genetically heterogeneous, and two genes, EXT1 and EXT2, located on 8q24 and 11p11-p12, respectively, ..
  34. ncbi Growth and fracture of an osteochondroma in an adult patient
    A Alonso-Torres
    Eur Radiol 14:2366-7. 2004
  35. ncbi Cervical osteochondroma as a cause of spinal cord compression in a patient with hereditary multiple exostoses: Computed tomography and magnetic resonance imaging findings
    Bayram Cirak
    Department of Neurosurgery, Pamukkale University, School of Medicine, Denizli, Turkey
    Australas Radiol 46:309-11. 2002
    ..We present CT and MR findings in a male patient with HME who developed spinal cord compression from a cervical osteochondroma. Complete recovery was achieved following surgery.
  36. ncbi Cytogenetic and molecular cytogenetic evidence of recurrent 8q24.1 loss in osteochondroma
    Michael G Feely
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Cancer Genet Cytogenet 137:102-7. 2002
    b>Osteochondroma most frequently arises sporadically and as a solitary lesion, but may also arise as multiple lesions characterizing the autosomal dominant disorder hereditary multiple exostoses (HME) and the contiguous gene-deletion ..
  37. ncbi The role of EXT1 in nonhereditary osteochondroma: identification of homozygous deletions
    Liesbeth Hameetman
    Department of Pathology, Leiden University Medical Center, PO Box 9600 L1 Q, 2300 RC Leiden, The Netherlands
    J Natl Cancer Inst 99:396-406. 2007
    ..We examined whether EXT1 might act as a classical tumor suppressor gene for nonhereditary osteochondromas...
  38. ncbi Osteochondroma of the upper cervical spine. A case report
    E Arasil
    Department of Neurosurgery, Faculty of Medicine, University of Ankara, Ibn i Sina Avicenna Hospital, Turkey
    Spine (Phila Pa 1976) 21:516-8. 1996
    STUDY DESIGN. A report of a patient with osteochondroma of the upper cervical spine causing radiculopathy. OBJECTIVES. The surgical treatment of this patient involved the complete removal of tumor and compression of neural structures...
  39. ncbi A rare brachial artery pseudoaneurysm 13 years after excision of a humeral osteochondroma
    Adam M Tobias
    Division of Plastic and Reconstructive Surgery, The Children s Hospital of Philadelphia, and University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Ann Plast Surg 52:419-22. 2004
    ..the third known report in the English literature of a brachial artery pseudoaneurysm associated with a humeral osteochondroma. In patients presenting with a painful upper arm mass and a history of multiple hereditary exostoses, one must ..
  40. ncbi Osteochondroma of the talus in a male adolescent
    Deepak Joshi
    Central Institute of Orthopaedics, Safdarjang Hospital, New Delhi, India
    J Am Podiatr Med Assoc 95:494-6. 2005
    b>Osteochondroma of the talus is rare but must be considered as part of the differential diagnosis of any swelling in this part of the skeleton...
  41. ncbi Recurring breakpoints of 1p13 approximately p22 in osteochondroma
    Jeffrey R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 Markham Street, Little Rock, AR 72205, USA
    Cancer Genet Cytogenet 138:102-6. 2002
    ..These findings indicate that aberrations of chromosome 1p, in a region spanning 1p13 approximately p22, may be nonrandomly involved in the cytogenetic progression of osteochondroma.
  42. ncbi Osteochondroma of the C5 lamina with cord compression: case report and review of the literature
    J Ratliff
    Department of Neurosurgery, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA
    Spine (Phila Pa 1976) 25:1293-5. 2000
    STUDY DESIGN: Case report of a solitary osteochondroma of the cervical spine causing myelopathy in a 66-year-old woman...
  43. ncbi Osteochondroma of the talar neck: a rare cause of callosity of the foot dorsum
    Selcuk Keser
    Orthopaedics and Traumatology, Karaelmas University, Zonguldak, Turkey
    J Am Podiatr Med Assoc 95:295-7. 2005
    b>Osteochondroma is the most common benign bone tumor. It rarely affects rearfoot bones, and only a few cases of talar osteochondroma have been reported...
  44. ncbi Extraskeletal paraarticular osteochondroma of the knee--a case report and tumor overview
    Aditya V Maheshwari
    Department of Orthopaedics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India
    Knee 13:411-4. 2006
    ..We present here such an infrapatellar lesion and discuss criteria helpful in distinguishing these benign lesions from other morphological similar lesions...
  45. ncbi Dysplasia epiphysealis hemimelica (Trevor disease): a rare developmental disorder of bone mimicking osteochondroma of long bones
    Rachel Glick
    Department of Pathology and Laboratory Medicine, New York University Hospital for Joint Diseases, New York, NY 10003, USA
    Hum Pathol 38:1265-72. 2007
    ..After 4 to 5 years of age, the lesions histologically resemble osteochondroma. To our knowledge, only one publication of this entity is available in an English pathology journal...
  46. ncbi Osteochondroma-like parosteal osteosarcoma
    Duddi Sreehari Krishna Swaroop
    Department of Pathology, Narayana Medical College, Nellore, Andhra Pradesh, India
    Indian J Pathol Microbiol 51:58-60. 2008
    ..It was mistaken for osteochondroma in the initial biopsy, and the possibility of bizarre parosteal osteochondromatous proliferation (BPOP) was ..
  47. ncbi A case report of osteochondroma of the frontotemporosphenoidal suture
    R Becelli
    Dept of Maxillofacial Surgery, University of Rome La Sapienza, Rome, Italy
    J Exp Clin Cancer Res 23:147-51. 2004
    b>Osteochondroma, also known as osteocartilaginous exostosis, is the most frequent benign bone tumour of the skeletal system...
  48. ncbi Surgical treatment of symptomatic osteochondroma. A three- to eight-year follow-up study
    F Bottner
    Department of Orthopaedics, University Hospital of Munster, Germany
    J Bone Joint Surg Br 85:1161-5. 2003
    ..There were 40 women and 46 men with a mean age of 20 years (3 to 62). Of these, 56 had a solitary osteochondroma and 30 had multiple hereditary tumours. The presenting symptoms were pain (79.1%), swelling (23...
  49. ncbi Fractures of osteochondroma during physical exercise
    Pedro Carpintero
    Orthopedics Department, University Hospital Reina Sofia, University of Cordoba, Spain
    Am J Sports Med 31:1003-6. 2003
    ..The mechanism responsible and the best form of treatment for fractures of osteochondromas remain unclear...
  50. pmc Acute popliteal pseudoaneurysm rupture secondary to distal femoral osteochondroma in a patient with hereditary multiple exostoses
    I S Vanhegan
    West Hertfordshire Hospitals NHS Trust, UK
    Ann R Coll Surg Engl 94:e134-6. 2012
    ..Pseudoaneurysms usually present as an enlarging mass behind the knee. Acute rupture of an occult popliteal pseudoaneurysm caused by a distal femoral exostosis has not been reported previously...
  51. ncbi Osteochondroma leading to proximal tibiofibular synostosis as a cause of persistent ankle pain and lateral knee pain: a case report
    Murat Bozkurt
    Department of Orthopaedics and Traumatology, Emergency Care and Traumatology Hospital, Balgat, Ankara, Turkey
    Knee Surg Sports Traumatol Arthrosc 12:152-4. 2004
    ..This paper presents a case report of persistent ankle pain and lateral knee pain due to existing proximal tibiofibular synostosis...
  52. ncbi A case of osteocartilaginous mass involving the coronoid process of the ulna: solitary osteochondroma or dysplasia epiphysealis hemimelica?
    Hirohito Takeuchi
    Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo City, Japan
    J Shoulder Elbow Surg 12:510-3. 2003
  53. ncbi Traumatic pseudoaneurysm of the brachial artery caused by an osteochondroma, mimicking biceps rupture in a weightlifter: a case report
    Scott J Koenig
    Division of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Am J Sports Med 32:1049-53. 2004
  54. ncbi Osteochondroma of C7 vertebra presenting as compressive myelopathy in a patient with nonhereditary (nonfamilial/sporadic) multiple exostoses
    Aditya V Maheshwari
    Dorr Institute of Arthritis Research and Education, Arthritis Institute, Centinela Freeman Regional Medical Center, 501, East Hardy Street, Suite 300, Inglewood, CA 90301, USA
    Arch Orthop Trauma Surg 126:654-9. 2006
    ..To the best of our knowledge, this is the first report of an osteochondroma arising from C7 vertebra presenting with compressive myelopathy in a patient with nonhereditary multiple ..
  55. pmc Seventh cervical vertebral body solitary osteochondroma. Report of a case and review of the literature
    Theodoros B Grivas
    Orthopaedic Department, Thriasion General Hospital, G Genimatas Av 19200, Magula, Attica, Greece
    Eur Spine J 14:795-8. 2005
    Solitary osteochondroma of the cervical spine is a rare manifestation of a common bony tumour. It can create symptoms, depending on the adjacent compressed structures...
  56. ncbi Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma
    Yiting Li
    Texas Children s Cancer Center, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
    Proteomics 6:3426-35. 2006
    ..detect OS, we used SELDI MS to perform proteomic profiling on plasma specimens from 29 OS and 20 age-matched osteochondroma (OC) patients...
  57. ncbi Osteochondroma of the skull base
    Tapan A Padhya
    Department of Otolaryngology Head and Neck Surgery, Moffitt Cancer Center at The University of South Florida, University of South Florida College of Medicine, Tampa, FL, USA
    Otolaryngol Head Neck Surg 137:166-8. 2007
  58. ncbi Spontaneous regression of solitary osteochondroma: reconsidering our approach
    Alexandre Arkader
    Division of Orthopaedic Surgery, Children s Hospital of Philadelphia, 2nd Floor Wood Center, 34th and Civic Center Blvd, Philadelphia, PA 19104 4399, USA
    Clin Orthop Relat Res 460:253-7. 2007
    ..We report a case of spontaneous regression of a solitary osteochondroma and review the literature...
  59. ncbi Spinal cord compression due to vertebral osteochondroma: report of two cases
    Afaf Faik
    Rheumatology Department B, El Ayachi Hospital, Rabat Salé Teaching Hospital, Morocco
    Joint Bone Spine 72:177-9. 2005
    b>Osteochondroma, or exostosis, is the most common of all benign bone tumors. Spinal osteochondromas are uncommon but may cause neurological compromise. We report two cases of spinal cord compression by osteochondromas...
  60. ncbi Course of spinal solitary osteochondromas
    Olivier Gille
    University Hospital of Bordeaux, Spinal Unit, Department of Orthopaedic Surgery, Bordeaux, France
    Spine (Phila Pa 1976) 30:E13-9. 2005
    ..Six spinal solitary osteochondromas...
  61. ncbi [Solitary osteochondroma of the elbow causing ulnar nerve compression: a case report]
    Lokman Karakurt
    Firat Universitesi Tip Fakultesi, Ortopedi ve Travmatoloji Anabilim Dali, Elazig
    Acta Orthop Traumatol Turc 38:291-4. 2004
    We report ulnar nerve compression caused by solitary osteochondroma of the right elbow in a 34-year-old man. Two osteochondromas were detected originating from the olecranon and medial humeral epicondyle, respectively...
  62. pmc Endoscopically assisted resection of a scapular osteochondroma causing snapping scapula syndrome
    Satoru Fukunaga
    Department of Orthopedic Surgery, Hyogo Medical University, Hyogo, Japan
    World J Surg Oncol 5:37. 2007
    b>Osteochondroma is the most common benign bone tumor in the scapula. This condition might lead to snapping scapula syndrome, which is characterized by painful, audible, and/or palpable abnormal scapulothoracic motion...
  63. ncbi Cortico-medullary continuity in bizarre parosteal osteochondromatous proliferation mimicking osteochondroma on imaging
    Leon D Rybak
    Department of Radiology, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003 3899, USA
    Skeletal Radiol 36:829-34. 2007
    ..It is believed that florid reactive periostitis, BPOP and turret osteochondroma may reflect points along the same continuum with trauma the likely inciting event...
  64. doi Peroneal nerve palsy resulting from fibular head osteochondroma
    Hichem Mnif
    Department of Orthopedics, Hospital Monastir, Road 1 June, Monastir, Tunisia
    Orthopedics 32:528. 2009
    This article describes a case of a 11-year-old boy with an osteochondroma of the peroneal head causing peroneal nerve palsy. Physical examination disclosed large exostoses palpated at the right fibular head...
  65. doi Extraskeletal osteochondroma near the hip: a pediatric case
    Zhen Jiang Liu
    Department of Pediatric Orthopedics, The Shengjing Hospital, China Medical University, Heping District, Shenyang, Liaoning, PR China
    J Pediatr Orthop B 19:524-8. 2010
    Extraskeletal osteochondroma near the hip is rare and its pathological diagnosis is based on radiological and histopathological examination...
  66. ncbi Osteochondroma of the coronoid process (Jacob's disease)
    Ufuk Emekli
    Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    J Oral Maxillofac Surg 60:1354-6. 2002
  67. ncbi Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation
    M D Murphey
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Rm M 133A, Washington, DC 20306, USA
    Radiographics 20:1407-34. 2000
    b>Osteochondroma represents the most common bone tumor and is a developmental lesion rather than a true neoplasm. It constitutes 20%-50% of all benign bone tumors and 10%-15% of all bone tumors...
  68. ncbi Scapular osteochondroma treated with arthroscopic excision using prone positioning
    Kristopher Aalderink
    Department of Orthopaedic Surgery, University of Iowa, Iowa City, 52242, USA
    Am J Orthop (Belle Mead NJ) 39:E11-4. 2010
    ..In this report, we describe the case of a woman in her mid-20s with painful scapular snapping and winging from an osteochondroma treated with arthroscopic excision using prone positioning.
  69. doi Spinal cord compression secondary to a thoracic vertebral osteochondroma
    Ye Tian
    Department of Orthopaedics, Chang Zheng Hospital, Shanghai, China
    J Neurosurg Spine 15:252-7. 2011
    The authors describe a case of spinal cord compression due to an osteochondroma arising from the T-6 vertebral body in a patient with hereditary multiple exostoses. This 16-year-old boy presented with spastic paraparesis...
  70. ncbi Popliteal artery pseudoaneurysm secondary to osteochondroma in children and adolescents: a case report and literature review
    Dimitrios V Petratos
    2nd Orthopaedic Department, Aghia Sophia Children s Hospital, Thivon and Papadiamantopoulou, Athens 11527, Greece
    J Surg Orthop Adv 18:205-10. 2009
    b>Osteochondroma is the most frequent bone tumor and can rarely cause vascular complications. False aneurysms of the popliteal artery due to an osteochondroma are not common in the pediatric population...
  71. ncbi Cartilaginous lesions of bone
    K K Unni
    Mayo Clinic, Department of Laboratory Medicine and Pathology, 200 First Street SW, Rochester, MN 55905, USA
    J Orthop Sci 6:457-72. 2001
    ..Most cartilaginous lesions are benign or of low-grade malignancy. However, there are some subtypes of chondrosarcoma that behave in a highly aggressive fashion...
  72. ncbi Endoscopic resection of a distal femoral osteochondroma: description of the technique and case report
    Arturo Almazán Díaz
    Centro Nacional de Rehabilitación Instituto de Ortopedia, Arthroscopy and Sports Medicine Department, Mexico City, Mexico
    Arthroscopy 18:23E. 2002
    This report describes the successful endoscopic treatment of an osteochondroma of the distal femur...
  73. doi Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation
    M Zuntini
    Department of Medical Genetics and Skeletal Rare Diseases, Rizzoli Orthopaedic Institute, Bologna, Italy
    Oncogene 29:3827-34. 2010
    b>Osteochondroma, the most common benign bone tumor, may occur as a sporadic lesion or as multiple neoplasms in the context of multiple osteochondromas syndrome...
  74. ncbi Osteochondroma of the cervical spine causing occipital nerve neuralgia. Case report
    S Baer-Henney
    Department of Neurosurgery, Hannover Medical School, Germany
    Neurol Res 23:777-9. 2001
    b>Osteochondroma is a rare tumor of the cervical spine. The authors present a rare case of osteochondroma narrowing the C 1/2 foramen and causing occipital neuralgia. Complete removal of the tumor was performed with release of the pain...
  75. ncbi Snapping scapula syndrome caused by subscapular osteochondroma
    Mehmet Nurullah Ermis
    2nd Department of Orthopedics and Traumatology, Haydarpasa Numune Training and Research Hospital, Kadikoy, Istanbul, Turkey
    Eklem Hastalik Cerrahisi 23:40-3. 2012
    ..This study aims to evaluate the results of surgical excisions of subscapular exostoses which caused snapping scapula syndrome...
  76. doi An analysis of indications for surgical excision and complications in 116 consecutive cases of osteochondroma
    Ghanshyam Narayan Khare
    Department of Orthopaedics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India
    Musculoskelet Surg 95:121-5. 2011
    The indications for surgery in 116 cases of osteochondroma included cosmetic problem in 38, pain (on hitting some object or continuous pain due to bursitis) in 50, pressure (on adjacent nerves) in 18, hindrances of joint movements in 8, ..
  77. ncbi Osteochondroma of the upper cervical spine presenting as vertigo
    Shigeo Akagi
    Department of Orthopedic Surgery, Kansai Medical University, Moriguchi City Osaka, Japan
    Orthopedics 26:187-8. 2003
  78. ncbi The natural history of disappearing bone tumours and tumour-like conditions
    T Yanagawa
    Department of Orthopedic Surgery, Gunma University Faculty of Medicine, Maebashi, Gunma, Japan
    Clin Radiol 56:877-86. 2001
    ..Knowledge of the potential for spontaneous resolution may help in management of these tumour and tumour-like lesions of bone...
  79. ncbi Peroneal nerve palsy secondary to proximal fibular osteochondroma--a case report
    W Hazmy
    Department of Orthopaedic and Traumatology, Seremban Hospital, Negeri Sembilan
    Med J Malaysia 56:89-90. 2001
    The author reports a case of a 11-year old child presented with peroneal nerve entrapment secondary to proximal fibular osteochondroma, with complete recovery of function following the excision of the tumor.
  80. ncbi Pseudowinging of the scapula due to subscapular osteochondroma
    Irfan Esenkaya
    Department of Orthopedics and Traumatology, Inonu University, School of Medicine, Malatya, Turkey
    Orthopedics 28:171-2. 2005
  81. ncbi Osteochondroma of the sacrum: a case report and review of the literature
    Dino Samartzis
    Graduate Division, Harvard University, Cambridge, MA, USA
    Spine (Phila Pa 1976) 31:E425-9. 2006
    ..A case report and review of the literature...
  82. ncbi Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma
    J V Bovée
    Department of Pathology, Leiden University Medical Center, The Netherlands
    Lab Invest 80:1925-34. 2000
    ..cartilage-forming tumors arising centrally in bone (central chondrosarcoma) or within the cartilaginous cap of osteochondroma (peripheral chondrosarcoma)...
  83. ncbi Cervical spinal cord compression due to an osteochondroma in hereditary multiple exostosis: case report and review of the literature
    Miguel Giudicissi-Filho
    Department of Neurosurgery, Center of Neurology and Neurosurgery Associates, Hospital Beneficência Portuguesa de São Paulo, Sao Paulo SP, Brazil
    Surg Neurol 66:S7-S11. 2006
    ..The objective of this manuscript is to describe a rare case of cervical myelopathy due to an exostosis arising from C7 in a patient with HME and a comprehensive review of the current literature...
  84. ncbi Spinal osteochondroma presenting as atypical spinal curvature: a case report
    James F Fiechtl
    Carolinas Medical Center, Charlotte, NC, USA
    Spine (Phila Pa 1976) 28:E252-5. 2003
    ..The case of an 8-year-old girl with hereditary multiple exostosis presenting with atypical spinal curvature is reported...
  85. ncbi Osteochondroma in the lumbar spinal canal causing sciatic pain: report of two cases
    Seiji Ohtori
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    J Orthop Sci 8:112-5. 2003
    A search of the English-language medical literature found only two cases in which expansion of an osteochondroma into the lumbar spinal canal caused sciatica...
  86. ncbi Extraskeletal para-articular osteochondroma of the posterior knee
    Aditya V Maheshwari
    Division of Musculoskeletal Oncology, University of Miami, Miller School of Medicine, Miami, FL, USA
    J Knee Surg 22:30-3. 2009
    ..Although the knee is a common location for extraskeletal para-articular osteochondroma, it has not been described arising in the posterior aspect of the knee...
  87. ncbi Chest wall deformity associated with osteochondroma of the scapula: a case report and review of the literature
    Hiroyasu Tomo
    Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Japan
    J Shoulder Elbow Surg 14:103-6. 2005
  88. doi Solitary pelvic osteochondroma causing L5 nerve root compression
    Whoan Jeang Kim
    Department of Orthopedic Surgery, Eulji University College of Medicine, Seo Gu, Daejeon, Republic of Korea
    Orthopedics 32:922. 2009
    b>Osteochondroma is the most common benign bone tumor, accounting for more than one-third of all benign bone tumors. It usually develops at the metaphysis of the long bones, especially the distal femur and proximal tibia...
  89. doi Giant solitary osteochondroma of the inferior medial calcaneal tubercle: a case report and review of the literature
    Neal M Blitz
    Kaiser North Bay Consortium Residency Program, Department of Orthopedics and Foot and Ankle Surgery, Kaiser Permanente Medical Centers, Santa Rosa, CA 95403, USA
    J Foot Ankle Surg 47:206-12. 2008
    ..b>Osteochondroma are often treated conservatively unless they become symptomatic, painful, demonstrate rapid or new growth, ..
  90. ncbi Transformation of solitary osteochondroma calcaneum to chondrosarcoma--a case report
    Reeni Malik
    Department of Pathology, Gandhi Medical College, Bhopal, Madhya Pradesh
    Indian J Pathol Microbiol 47:42-3. 2004
    Solitary osteochondroma of calcaneum is an uncommon benign tumor. Its malignant transformation to chondrosarcoma is rarely encountered. Pain and recent enlargement are clinical manifestations of this complication...
  91. ncbi Case reports: enlargement of a calcaneal osteochondroma after skeletal maturity
    Alexis Nogier
    Department of Orthopaedics, Cochin Teaching Hospital, Paris, France
    Clin Orthop Relat Res 447:260-6. 2006
    Growth or radiologic modification of an osteochondroma after the epiphyseal plate closes suggests the diagnosis of malignant transformation to a chondrosarcoma...
  92. ncbi Intra-articular osteochondroma of the posterior cavity of the knee
    Michael Dienst
    Clinic for Orthopaedic Surgery, University Hospital, 66421 Homburg Saar, Germany
    Arch Orthop Trauma Surg 122:462-5. 2002
    A patient with a large intra-articular osteochondroma of the posterior cavity of the knee joint is presented...
  93. ncbi [Benign cartilaginous tumors]
    R Erlemann
    , St. Johannes-Hospital, An der Abtei 7-11, 47166 Duisburg
    Radiologe 41:548-59. 2001
    ..chondrosarcoma from an enchondroma is difficult, and differentiation of a peripheral chondrosarcoma from an osteochondroma can be difficult...
  94. ncbi Bizarre parosteal osteochondromatous proliferation of the hand: report of two cases
    L De Smet
    Upper Limb Unit of the Orthopedic Surgery Department, University Hospital Pellenberg, Katholieke Universiteit, Leuven, Belgium
    Chir Main 20:247-50. 2001
    ..Bizarre parosteal osteochondromatous proliferation is a rare tumor usually localized in the hand. We report two new cases, one in the thumb of a middle aged woman and one in the terminal phalanx of a young haemophiliac patient...
  95. ncbi An unusual cause and presentation of a pelvic mass
    S Harish
    Department of Radiology, Addenbrooke s Hospital, Cambridge, UK
    Br J Radiol 79:177-8. 2006
  96. ncbi [Bizarre parosteal osteochondromatous proliferation (Nora's lesion). Two case reports]
    Y Le Bellec
    Clinique de l Yvene, centre SOS main, 43, route de Corbeil, 91160 Longjumeau, France
    Chir Main 24:265-9. 2005
    ..The diagnosis can be made thanks to imaging techniques and confirmed by histological examination. The treatment is surgical, namely complete excision but there is a high rate of local relapse...
  97. ncbi Radiology-pathology conference: osteosarcoma in a cartilaginous exostosis of the femur
    Stefan A Meissner
    Department of General Orthopaedics, Westfalian Wilhelms University of Munster, University Hospital, Albert Schweitzer Street 33, 48149 Munster, Northrhine Westfalia, Germany
    Clin Imaging 30:206-9. 2006
    ..We present the case of a 20-year-old patient with an osteosarcoma at the base of a cartilaginous exostosis and discuss the causal relationship between the two lesions on the basis of the radiologic and pathologic findings...
  98. ncbi EXT-related pathways are not involved in the pathogenesis of dysplasia epiphysealis hemimelica and metachondromatosis
    J V M G Bovée
    Department of Pathology, Leiden University Medical Centre, The Netherlands
    J Pathol 209:411-9. 2006
    ..The EXT genes, involved in the hereditary multiple osteochondromas syndrome, and downregulated in osteochondroma, were normally expressed in DEH and MC as shown by quantitative reverse transcriptase-polymerase chain ..
  99. ncbi Variants of exostosis of the bone in children
    Randy Ray Richardson
    Pediatric Radiologist, Phoenix Children s Hospital, Mesa, AZ 85201, USA
    Semin Roentgenol 40:380-90. 2005
  100. ncbi [Osteogenic exostosis of the capitate bone. Case report and review of the literature]
    E Roulot
    Institut de la Main, square Jouvenet, 75016, Paris, France
    Chir Main 20:158-63. 2001
    The occurrence of an osteochondroma in the carpus is very rare and its excision is indicated in the case of significant symptoms or change in its appearance...
  101. ncbi Osteochondroma of the trochlea presenting as acquired Brown syndrome: a case report
    Mohammed R Talebnejad
    Department of Ophthalmology, Shiraz University Medical School, Shiraz, Iran
    J AAPOS 11:305-6. 2007
    ..Histopathology was consistent with osteochondroma of the trochlea...

Research Grants2

  1. Strategy for Therapy of the Pseudoachondroplasia (PSACH) Phenotype: Understanding
    Jacqueline Hecht; Fiscal Year: 2006
    ..abstract_text> ..
  2. Genetic Studies of Clubfoot (ITEV)
    Jacqueline T Hecht; Fiscal Year: 2010
    ..Identification of high-risk genotypes can lead to the development of prevention programs in selected populations and may suggest gene-based prevention strategies. ..