respiratory sounds

Summary

Summary: Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.

Top Publications

  1. ncbi Rhinovirus illnesses during infancy predict subsequent childhood wheezing
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 9988, USA edu
    J Allergy Clin Immunol 116:571-7. 2005
  2. ncbi Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants
    Y Miyake
    Dept of Public Health Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Eur Respir J 35:1228-34. 2010
  3. ncbi Childhood asthma after bacterial colonization of the airway in neonates
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 357:1487-95. 2007
  4. ncbi Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA
    Olga E Savenije
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 127:1505-12.e14. 2011
  5. ncbi Global strategy for the diagnosis and management of asthma in children 5 years and younger
    Soren Erik Pedersen
    Pediatric Research Unit, Kolding Hospital, Kolding, Denmark
    Pediatr Pulmonol 46:1-17. 2011
  6. ncbi An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children
    Nicole Beydon
    Am J Respir Crit Care Med 175:1304-45. 2007
  7. pmc Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban center
    Mauricio L Barreto
    Instituto De Saude Coletiva, Universidade Federal da Bahia, Salvador, Brazil
    Respir Res 11:167. 2010
  8. ncbi Intermittent inhaled corticosteroids in infants with episodic wheezing
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 354:1998-2005. 2006
  9. pmc Parental smoking and children's respiratory health: independent effects of prenatal and postnatal exposure
    Sam Pattenden
    London School of Hygiene and Tropical Medicine, London, UK
    Tob Control 15:294-301. 2006
  10. ncbi Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life
    Nele Sigurs
    Department of Paediatrics, Borås Central Hospital, Borås S 50182, Sweden
    Thorax 65:1045-52. 2010

Research Grants

Detail Information

Publications284 found, 100 shown here

  1. ncbi Rhinovirus illnesses during infancy predict subsequent childhood wheezing
    Robert F Lemanske
    Department of Pediatrics, University of Wisconsin, Madison, WI 53792 9988, USA edu
    J Allergy Clin Immunol 116:571-7. 2005
    ..The contribution of viral respiratory infections during infancy to the development of subsequent wheezing and/or allergic diseases in early childhood is not established...
  2. ncbi Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants
    Y Miyake
    Dept of Public Health Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Eur Respir J 35:1228-34. 2010
    ..98), respectively). Higher consumption of calcium and dairy foods other than yoghurt during pregnancy may reduce the risk of infantile wheeze. Higher vitamin D intake during pregnancy may be protective against childhood wheeze and eczema...
  3. ncbi Childhood asthma after bacterial colonization of the airway in neonates
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 357:1487-95. 2007
    ..We conducted a study to investigate a possible association between bacterial colonization of the hypopharynx in asymptomatic neonates and later development of recurrent wheeze, asthma, and allergy during the first 5 years of life...
  4. ncbi Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA
    Olga E Savenije
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Allergy Clin Immunol 127:1505-12.e14. 2011
    ..It is unclear whether these phenotypes can be replicated in other birth cohorts...
  5. ncbi Global strategy for the diagnosis and management of asthma in children 5 years and younger
    Soren Erik Pedersen
    Pediatric Research Unit, Kolding Hospital, Kolding, Denmark
    Pediatr Pulmonol 46:1-17. 2011
    ..Patients in this age group are often managed by pediatricians and general practitioners routinely faced with a wide variety of issues related to childhood diseases...
  6. ncbi An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children
    Nicole Beydon
    Am J Respir Crit Care Med 175:1304-45. 2007
  7. pmc Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban center
    Mauricio L Barreto
    Instituto De Saude Coletiva, Universidade Federal da Bahia, Salvador, Brazil
    Respir Res 11:167. 2010
    ..Risk factors for atopic and non-atopic asthma may be different. This study aimed to analyze the associations between markers of poverty, dirt and infections and wheezing in atopic and non-atopic children...
  8. ncbi Intermittent inhaled corticosteroids in infants with episodic wheezing
    Hans Bisgaard
    Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen
    N Engl J Med 354:1998-2005. 2006
    ....
  9. pmc Parental smoking and children's respiratory health: independent effects of prenatal and postnatal exposure
    Sam Pattenden
    London School of Hygiene and Tropical Medicine, London, UK
    Tob Control 15:294-301. 2006
    ..We investigate this in a pooled analysis, on 53,879 children from 12 cross-sectional studies--components of the PATY study (Pollution And The Young)...
  10. ncbi Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life
    Nele Sigurs
    Department of Paediatrics, Borås Central Hospital, Borås S 50182, Sweden
    Thorax 65:1045-52. 2010
    ..A study was undertaken to examine whether these features persist into early adulthood, to report longitudinal wheeze and allergy patterns, and to see how large and small airway function relates to RSV infection and asthma...
  11. ncbi The effect of single and multiple infections on atopy and wheezing in children
    Neuza Maria Alcântara-Neves
    Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    J Allergy Clin Immunol 129:359-67, 367.e1-3. 2012
    ..However, the findings of epidemiologic studies investigating the association between infection with atopy and asthma have been inconsistent...
  12. ncbi Not all farming environments protect against the development of asthma and wheeze in children
    Markus Johannes Ege
    University Children s Hospital Munich, Germany
    J Allergy Clin Immunol 119:1140-7. 2007
    ..Inconsistent data on the relation of farming to asthma and wheeze have raised some doubt about a true protective effect...
  13. ncbi Phenotypes of childhood asthma: are they real?
    B D Spycher
    Swiss Paediatric Respiratory Research Group, Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Clin Exp Allergy 40:1130-41. 2010
    ..Ultimately, the underlying pathophysiology and aetiology will need to be understood to properly characterize the diseases causing recurrent wheeze in children...
  14. ncbi Long-term airway morbidity following viral LRTI in early infancy: recurrent wheezing or asthma?
    Renato T Stein
    Departamento de Pediatria, Faculdade de Medicina, Pontificia Universidade Catolica, Porto Alegre, Brazil
    Paediatr Respir Rev 10:29-31. 2009
    ..Prospective trials with anti-viral strategies, including potential new vaccines, should give us better understanding of the role of viral infections in early life in the causation of childhood asthma...
  15. ncbi Phenotypic differences between pediatric and adult asthma
    Andrew Bush
    Department of Paediatric Respiratory Medicine, Imperial School of Medicine at National Heart and Lung Institute, London, United Kingdom
    Proc Am Thorac Soc 6:712-9. 2009
    ..Retrospective recall of childhood events is of limited value. In conclusion, a full understanding the multifaceted phenotypes of asthma requires a thorough knowledge of early life events and their consequences over many decades...
  16. ncbi Neural classification of lung sounds using wavelet coefficients
    A Kandaswamy
    Department of Electronics and Communication Engineering, PSG College of Technology, Coimbatore 641 004, India
    Comput Biol Med 34:523-37. 2004
    ..An ANN based system, trained using the resilient back propagation algorithm, was implemented to classify the lung sounds to one of the six categories: normal, wheeze, crackle, squawk, stridor, or rhonchus...
  17. ncbi A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status
    Helen L Rhodes
    Department of Paediatrics, Poole Hospital, Poole Dorset Research and Development Support Unit, Poole Hospital Bournemouth University, Bournemouth, United Kingdom
    Am J Respir Crit Care Med 165:176-80. 2002
    ..In conclusion, adults with asthma can begin wheezing at any age but tend to sensitize early and have abnormal airway characteristics by the age of 11 yr...
  18. pmc Increased prevalence of symptoms of rhinitis but not of asthma between 1990 and 2008 in Swedish adults: comparisons of the ECRHS and GA²LEN surveys
    Anders Bjerg
    The OLIN Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, Lulea, Sweden
    PLoS ONE 6:e16082. 2011
    ..This study aimed to compare the prevalence of asthma symptoms and their major determinants, rhinitis and smoking, in Swedish young adults in 1990 and 2008...
  19. pmc Human rhinovirus infection in young African children with acute wheezing
    Heidi E Smuts
    Division Medical Virology NHLS, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa
    BMC Infect Dis 11:65. 2011
    ..The aim of this study was to determine the role of HRV as a cause of acute wheezing in South African children...
  20. pmc Pediatric asthma: natural history, assessment, and treatment
    Ronit Herzog
    Department of Pediatrics, Division of Allergy, Immunology and Pulmonology, Weill Medical College of Cornell University, New York, NY, USA
    Mt Sinai J Med 78:645-60. 2011
    ..This review focuses on the recent studies that led to the current understanding of asthma phenotypes in childhood and the recommended treatments...
  21. ncbi Pattern recognition methods applied to respiratory sounds classification into normal and wheeze classes
    Mohammed Bahoura
    Department of Engineering, University of Quebec at Rimouski, allée des Ursulines, Que, Canada
    Comput Biol Med 39:824-43. 2009
    In this paper, we present the pattern recognition methods proposed to classify respiratory sounds into normal and wheeze classes...
  22. ncbi Time-frequency detection and analysis of wheezes during forced exhalation
    Antoni Homs-Corbera
    Department of Automatic Control ESAII, Biomedical Engineering Research Center CREB, Technical University of Catalonia UPC, 08028 Barcelona, Spain
    IEEE Trans Biomed Eng 51:182-6. 2004
    ..0195). Finally, limited bandwidth parameters, which measure the bronchodilator response, were also studied...
  23. ncbi Wheeze detection based on time-frequency analysis of breath sounds
    Styliani A Taplidou
    Faculty of Engineering, Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, University Campus, Thessaloniki, Greece
    Comput Biol Med 37:1073-83. 2007
    ..In addition, the TF-WD was tested against artificial noise. The experimental and testing results justified the efficient performance and high noise robustness of the TF-WD...
  24. ncbi Asthma symptoms and medication in the PIAMA birth cohort: evidence for under and overtreatment
    Daan Caudri
    Department of Pediatrics Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands
    Pediatr Allergy Immunol 22:652-9. 2011
    ..Our aim was to investigate whether inhaled medication use in young children was in agreement with asthma symptoms at the age of 2-8 yr...
  25. pmc Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study
    Debra A Stern
    Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
    Lancet 372:1058-64. 2008
    ..Incidence of asthma increases during early adulthood. We aimed to estimate the contributions of sex and early life factors to asthma diagnosed in young adults...
  26. ncbi International prevalence of recurrent wheezing during the first year of life: variability, treatment patterns and use of health resources
    Javier Mallol
    Department of Pediatric Respiratory Medicine, Hospital El Pino, University of Santiago de Chile, Santiago, Chile
    Thorax 65:1004-9. 2010
    ..A study was undertaken to determine the prevalence of RW in infants during their first year of life in affluent and non-affluent localities...
  27. pmc Daily or intermittent budesonide in preschool children with recurrent wheezing
    Robert S Zeiger
    Department of Allergy, Kaiser Permanente Southern California, San Diego, CA 92111, USA
    N Engl J Med 365:1990-2001. 2011
    ..We compared daily therapy with intermittent therapy...
  28. ncbi Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheezing, and asthma in offspring
    Eva Morales
    Center for Research in Environmental Epidemiology, Barcelona, Catalonia, Spain
    Epidemiology 23:64-71. 2012
    ..We assessed whether maternal circulating 25-hydroxyvitamin D (25[OH]D) concentrations in pregnancy are associated with risk of lower respiratory tract infections, wheezing, and asthma in the offspring...
  29. ncbi A randomized intervention of montelukast for post-bronchiolitis: effect on eosinophil degranulation
    Chang Keun Kim
    Department of Pediatrics and Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
    J Pediatr 156:749-54. 2010
    ..To investigate the effect of montelukast on eosinophil degranulation and recurrent wheezing episodes in post-respiratory syncytial virus (RSV) bronchiolitis...
  30. ncbi Polymorphisms in inflammation genes, tobacco smoke and furred pets and wheeze in children
    Mette Sørensen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden, Copenhagen, Denmark
    Pediatr Allergy Immunol 20:614-23. 2009
    ..Polymorphisms in IL-8 affected the association between pet-keeping and risk of wheeze. Polymorphisms in inflammation genes might affect the association between environmental exposures and risk of recurrent wheeze in early childhood...
  31. ncbi Female gender is associated with higher incidence and more stable respiratory symptoms during adolescence
    Elin Tollefsen
    Department of Respiratory Medicine, Trondheim University Hospital, Trondheim, Norway
    Respir Med 101:896-902. 2007
    ..The impact of smoking and overweight may put girls at a higher risk of respiratory symptoms than boys. Awareness of the gender difference in respiratory symptoms is important for diagnosis and preventive strategies during adolescence...
  32. ncbi Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study
    E M Hollams
    Telethon Institute for Child Health, 100 Roberts Road, Subiaco WA 6008, Australia
    Eur Respir J 38:1320-7. 2011
    ..In a large unselected cohort, males with inadequate vitamin D at 6 and 14 yrs of age had increased atopy and BHR. Low vitamin D at age 6 yrs was a predictor of atopy and asthma at 14 yrs of age...
  33. ncbi Role of rhinovirus C respiratory infections in sick and healthy children in Spain
    Cristina Calvo
    Department of Pediatrics, Hospital Severo Ochoa, Leganes, Madrid, Spain
    Pediatr Infect Dis J 29:717-20. 2010
    ..Recently a new genogroup of human rhinovirus (HRV) has been described and named HRV-C. The relative importance of HRV-C in viral respiratory tract illnesses is unknown...
  34. ncbi Time trends in asthma and wheeze in Swedish children 1996-2006: prevalence and risk factors by sex
    Anders Bjerg
    The OLIN Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, Lulea, Sweden
    Allergy 65:48-55. 2010
    ..We sought to investigate sex-specific trends in wheeze, asthma, allergic conditions, allergic sensitization and risk factors for wheeze...
  35. pmc Role of viral respiratory infections in asthma and asthma exacerbations
    William W Busse
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Lancet 376:826-34. 2010
    ....
  36. ncbi Indoor molds, bacteria, microbial volatile organic compounds and plasticizers in schools--associations with asthma and respiratory symptoms in pupils
    J L Kim
    Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University and University Hospital, Uppsala, Sweden
    Indoor Air 17:153-63. 2007
    ..05), daytime breathlessness (P < 0.05), doctor-diagnosed asthma (P < 0.05), and current asthma (P < 0.05). In conclusion, exposure to MVOC and plasticizers at school may be a risk factor for asthmatic symptoms in children...
  37. ncbi Fetal exposure to maternal and paternal smoking and the risks of wheezing in preschool children: the Generation R Study
    Liesbeth Duijts
    The Generation R Study, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Chest 141:876-85. 2012
    ..We examined the associations of parental smoking during pregnancy with wheezing in preschool children and whether these associations are explained by postnatal smoke exposure or small for gestational age at birth...
  38. pmc The ABCs of rhinoviruses, wheezing, and asthma
    James E Gern
    Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    J Virol 84:7418-26. 2010
    ..The close relationship between HRV infections and asthma suggests that antiviral treatments could have a major impact on the morbidity associated with this chronic respiratory disease...
  39. ncbi Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing
    Peter W Heymann
    Department of Pediatrics, University of Virginia Health System, Charlottesville, VA 22908 0386, USA
    J Allergy Clin Immunol 114:239-47. 2004
    ..However, information about the relationship between viral infections and atopy among children whose attacks of wheezing lead to hospitalization is unclear...
  40. pmc Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA cohort study
    M H Brutsche
    Pneumologie, University Hospital Basel, Petersgraben 4, CH 4031 Basel, Switzerland
    Thorax 61:671-7. 2006
    ..We hypothesised that BHR might play a role in the development of chronic obstructive pulmonary disease (COPD) as well as asthma...
  41. ncbi Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood--report of the German Multicentre Allergy Study (MAS 90)
    S Lau
    Department of Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany
    Allergy 60:766-73. 2005
    ....
  42. ncbi Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children
    Tuomas Jartti
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    J Med Virol 72:695-9. 2004
    ..The study shows that after the onset of symptomatic respiratory infection enterovirus RNA may take 2-3 weeks and rhinovirus RNA 5-6 weeks to disappear from nasal mucus...
  43. ncbi Dietary factors associated with wheezing and allergic rhinitis in children
    S Farchi
    Agency for Public Health, Lazio Region, Rome, Italy
    Eur Respir J 22:772-80. 2003
    ..Dietary antioxidants in vegetables may reduce wheezing symptoms in childhood, whereas both butter and margarine may increase the occurrence of such symptoms...
  44. ncbi Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children
    F D Gilliland
    Keck School of Medicine, Department of Preventive Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am J Respir Crit Care Med 163:429-36. 2001
    ..that ETS operates as a cofactor with other insults such as intercurrent infections as a trigger of wheezing attacks, rather than as a factor that induces asthma, whereas in utero exposure acts to increase physician-diagnosed asthma..
  45. ncbi A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
    Malcolm R Sears
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ont, Canada
    N Engl J Med 349:1414-22. 2003
    ..The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse...
  46. pmc The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children
    Neuza M Alcantara-Neves
    Departmento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil
    Respir Res 11:114. 2010
    ..In developing countries, intestinal helminthic infections have also been associated with allergy or atopy-related disorders...
  47. ncbi Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study
    John Henderson
    Department of Respiratory Medicine, Bristol Royal Hospital for Children, UK
    Pediatr Allergy Immunol 16:386-92. 2005
    ..5 [1.4, 4.3]) but not with atopy (OR 0.7 [0.2, 1.7]). In a population-based birth cohort, RSV bronchiolitis was associated with subsequent wheezing and asthma but not with the development of atopy by age 7 yr...
  48. ncbi Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study
    Malcolm R Sears
    Department of Medicine, McMaster University, Ontario, Hamilton, Canada
    Lancet 360:901-7. 2002
    ..Breastfeeding is widely advocated to reduce risk of atopy and asthma, but the evidence for such an effect is conflicting. We aimed to assess long-term outcomes of asthma and atopy related to breastfeeding in a New Zealand birth cohort...
  49. ncbi Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema
    Roger B Newson
    Department of Public Health Sciences, Guy s, King s and St Thomas School of Medicine, King s College, London, UK
    J Allergy Clin Immunol 114:531-7. 2004
    ..Few studies have explored whether fetal exposure to n-6 and n-3 fatty acids influences the inception of atopic disease...
  50. ncbi Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty
    Stefano Guerra
    Arizona Respiratory Center, University of Arizona, 1501 North Campbell Avenue, P O Box 245030, Tucson, AZ 85724 5030, USA
    Am J Respir Crit Care Med 170:78-85. 2004
    ..Our findings from a population-based longitudinal cohort challenge the commonly held view that asthma usually remits during adolescence...
  51. pmc Systematic review of worldwide variations of the prevalence of wheezing symptoms in children
    Swatee P Patel
    School of Health and Social Care, University of Greenwich, Southwood Site, Avery Hill Road, London SE9 2UG, UK
    Environ Health 7:57. 2008
    ..Considerable variation in the prevalence of childhood asthma and its symptoms (wheezing) has been observed in previous studies and there is evidence that the prevalence has been increasing over time...
  52. ncbi Neonatal antibiotic treatment is a risk factor for early wheezing
    Bernt Alm
    Department of Pediatrics, Goteborg University, Queen Silvia Children s Hospital, SE 416 85 Goteborg, Sweden
    Pediatrics 121:697-702. 2008
    ..As a result, there has been a risk of reverse causation. To minimize the risk of reverse causation, we have focused on the effect of antibiotics that are already administered on the neonatal ward...
  53. pmc The impact of respiratory viral infection on wheezing illnesses and asthma exacerbations
    Kecia N Carroll
    Department of Pediatrics, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 2504, USA
    Immunol Allergy Clin North Am 28:539-61, viii. 2008
    ....
  54. ncbi Wheeze and asthma prevalence and related health-service use in white and south Asian pre-schoolchildren in the United Kingdom
    C E Kuehni
    Institute of Social and Preventive Medicine, Swiss Paediatric Respiratory Research Group, University of Bern, Bern, Switzerland
    Clin Exp Allergy 37:1738-46. 2007
    ..These studies have not distinguished different asthma phenotypes or controlled for varying environmental exposures...
  55. ncbi Day-care attendance, position in sibship, and early childhood wheezing: a population-based birth cohort study
    Nicolaos C Nicolaou
    School of Translational Medicine, University of Manchester, University Hospital of South Manchester, National Health Service Foundation Trust, Manchester, United Kingdom
    J Allergy Clin Immunol 122:500-6.e5. 2008
    ..There are conflicting data on the effect of day-care attendance and position in sibship on the development of wheezing...
  56. pmc Assessment and management of children aged 1-59 months presenting with wheeze, fast breathing, and/or lower chest indrawing; results of a multicentre descriptive study in Pakistan
    T Hazir
    The Children s Hospital, Islamabad, Pakistan
    Arch Dis Child 89:1049-54. 2004
    ..To improve the WHO case management guidelines, more data is needed about the clinical outcome in children with wheezing/pneumonia overlap...
  57. ncbi Variation in family physicians' recording of auscultation abnormalities in patients with acute cough is not explained by case mix. A study from 12 European networks
    Nick A Francis
    Cochrane Institute of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff CF14 4YS, UK
    Eur J Gen Pract 19:77-84. 2013
    ..Conflicting data on the diagnostic and prognostic value of auscultation abnormalities may be partly explained by inconsistent use of terminology...
  58. ncbi Tobacco smoke exposure, wheeze, and atopy
    Clare S Murray
    North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    Pediatr Pulmonol 37:492-8. 2004
    ..However, ETS exposure has little or no effect on the development of atopy. Measurement of plasma cotinine was no more useful than tobacco exposure assessment by questionnaire in our cohort...
  59. pmc Effects of geohelminth infection and age on the associations between allergen-specific IgE, skin test reactivity and wheeze: a case-control study
    A L Moncayo
    Instituto De Saude Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil
    Clin Exp Allergy 43:60-72. 2013
    ..Most childhood asthma in poor populations in Latin America is not associated with aeroallergen sensitization, an observation that could be explained by the attenuation of atopy by chronic helminth infections or effects of age...
  60. ncbi [Relationship between lower respiratory tract infections in the first year of life and the development of asthma and wheezing in children]
    Carme Puig
    IMIM Hospital del Mar, Barcelona, Espana
    Arch Bronconeumol 46:514-21. 2010
    ....
  61. pmc Computerized lung sound analysis as diagnostic aid for the detection of abnormal lung sounds: a systematic review and meta-analysis
    Arati Gurung
    Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Respir Med 105:1396-403. 2011
    ..Electronic auscultation and automated classification of recorded lung sounds may help prevent some of these shortcomings...
  62. ncbi A bioacoustic method for timing of the different phases of the breathing cycle and monitoring of breathing frequency
    P Hult
    Department of Biomedical Engineering and Medicine and Care, Clinical Physiology, Linkoping University, S 581 85, Linkoping, Sweden
    Med Eng Phys 22:425-33. 2000
    ....
  63. ncbi A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization
    T R Abrahamsson
    Department of Clinical and Experimental Medicine, Division of Pediatrics, Linkoping University, Linkoping, Sweden
    Clin Exp Allergy 41:1729-39. 2011
    ..Analyses of circulating chemokines offer novel tools to investigate the T helper (Th)1/Th2 imbalance in allergic disease in vivo...
  64. pmc Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma
    Theresa W Guilbert
    Department of Pediatrics, University of Wisconsin Madison, Madison, WI 53716, USA
    J Allergy Clin Immunol 128:532-8.e1-10. 2011
    ..Preschool rhinovirus (RV) wheezing illnesses predict an increased risk of childhood asthma; however, it is not clear how specific viral illnesses in early life relate to lung function later on in childhood...
  65. ncbi Prevalence of chronic respiratory symptoms among Ohio cash grain farmers
    J R Wilkins
    Division of Epidemiology and Biometrics, School of Public Health, Ohio State University, Columbus, USA
    Am J Ind Med 35:150-63. 1999
    ..The prevalence of chronic cough, chronic phlegm, dyspnea, and non-cold wheeze was estimated from a mixed-mode survey of Ohio cash grain farmers in 1993...
  66. ncbi The role of prenatal, perinatal and postnatal factors in the explanation of socioeconomic inequalities in preschool asthma symptoms: the Generation R Study
    Esther Hafkamp-de Groen
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    J Epidemiol Community Health 66:1017-24. 2012
    ....
  67. ncbi Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment
    Angela Simpson
    North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, UK
    Am J Respir Crit Care Med 174:386-92. 2006
    ..High endotoxin exposure may reduce the risk of allergic sensitization...
  68. pmc Residential exposure to motor vehicle emissions and the risk of wheezing among 7-8 year-old schoolchildren: a city-wide cross-sectional study in Nicosia, Cyprus
    Nicos Middleton
    Department of Nursing, School of Health Sciences, Cyprus University of Technology, Nicosia, Cyprus
    Environ Health 9:28. 2010
    ..This study investigates the relationship between self-reported symptoms and residential exposure to motor vehicle emissions among Nicosia schoolchildren...
  69. pmc Narrative review: should teaching of the respiratory physical examination be restricted only to signs with proven reliability and validity?
    Jochanan Benbassat
    Myers JDC Brookdale Institute, Smokler Center for Health Policy Research, Jerusalem, Israel
    J Gen Intern Med 25:865-72. 2010
    ....
  70. ncbi Wheeze monitoring in children for assessment of nocturnal asthma and response to therapy
    L Bentur
    Division of Paediatric Pulmonology, Rambam Medical Centre, Haifa, Israel
    Eur Respir J 21:621-6. 2003
    ..Wheeze monitoring provides quantitative and noninvasive information about the extent of nocturnal wheezing in children, correlates well with conventional indices of asthma activity and can assist in assessing efficacy of treatment...
  71. ncbi Role of emerging respiratory viruses in children with severe acute wheezing
    M L García-García
    Pediatrics Department, Severo Ochoa Hospital, Madrid, Spain
    Pediatr Pulmonol 45:585-91. 2010
    ..Acute wheezing episodes are frequently associated with respiratory viral infections in children. However, the role of the recently described respiratory viruses is not yet fully understood...
  72. ncbi Prevalence and risk factors of wheeze and eczema in 1-year-old children: the Butajira birth cohort, Ethiopia
    Y Belyhun
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Ethiopia
    Clin Exp Allergy 40:619-26. 2010
    ..The rising global prevalence of asthma and other allergic conditions has been linked to potential aetiological factors influencing the developing immune system...
  73. ncbi Impact of innate and environmental factors on wheezing persistence during childhood
    Jocelyne Just
    Centre de l Asthme et des Allergies, Groupe Hospitalier Trousseau La Roche Guyon, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie Paris 6, Paris, France
    J Asthma 47:412-6. 2010
    ..Persistent asthma in adults starts often early in childhood and is associated with alterations in respiratory function that occur early in life...
  74. pmc What drives prescribing of asthma medication to children? A multilevel population-based study
    Mira G P Zuidgeest
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences UIPS, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Ann Fam Med 7:32-40. 2009
    ..This challenge creates an opportunity for variability in prescribing. The aim of our study was to investigate how and to what degree patient, family, and physician characteristics influence prescribing of asthma medication in children...
  75. pmc Mold damage in homes and wheezing in infants
    Seung Hyun Cho
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    Ann Allergy Asthma Immunol 97:539-45. 2006
    ..In most studies that investigate the association of mold or water damage and respiratory disorders in infants, the analysis is not adjusted for exposure to house dust mite (HDM), which is also a known cause of respiratory illnesses...
  76. ncbi The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze
    A Schultz
    School of Paediatric and Child Health, University of Western Australia, Perth, WA, Australia
    Acta Paediatr 99:56-60. 2010
    ..A recently proposed method for classifying preschool wheeze is to describe it as either episodic (viral) wheeze or multiple trigger wheeze. In research studies, phenotype is generally determined by retrospective questionnaire...
  77. ncbi Duration and exclusiveness of breastfeeding and childhood asthma-related symptoms
    A M M Sonnenschein-van der Voort
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur Respir J 39:81-9. 2012
    ..These associations seemed, at least partly, to be explained by infectious, but not by atopic, mechanisms...
  78. ncbi Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study
    Clare S Murray
    University of Manchester, North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, UK
    Lancet 368:754-62. 2006
    ..We tested our hypothesis that to prevent loss of lung function and worsening asthma later in childhood, anti-inflammatory treatment needs to be started early in life...
  79. ncbi Associations of obesity, sleep-disordered breathing, and wheezing in children
    Loreto G Sulit
    Division of Clinical Epidemiology, Rainbow Babies and Children s Hospital, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106 6003, USA
    Am J Respir Crit Care Med 171:659-64. 2005
    ..We conclude that SDB and obesity each are associated with asthma and wheeze. The relationship between obesity and wheeze may be partly mediated by factors associated with SDB...
  80. pmc Exhaled nitric oxide, susceptibility and new-onset asthma in the Children's Health Study
    T M Bastain
    Dept of Preventive Medicine, Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Eur Respir J 37:523-31. 2011
    ..Our results indicate that children with elevated F(eNO) are at increased risk for new-onset asthma, especially if they have no parental history of asthma...
  81. pmc Risk factors for atopic and non-atopic asthma in a rural area of Ecuador
    Ana Lucia Moncayo
    Instituto de Saúde Coletiva Universidade Federal da Bahia, Rua Basílio da Gama, S N, Salvador, Bahia, CEP 40 110 040 Brazil
    Thorax 65:409-16. 2010
    ..Distinct risk factors were associated with the two wheeze phenotypes and may indicate different causal mechanisms. Future preventive strategies in such populations may need to be targeted at the causes of non-atopic wheeze...
  82. pmc Air pollution, aeroallergens, and emergency room visits for acute respiratory diseases and gastroenteric disorders among young children in six Italian cities
    Flavia Orazzo
    Pediatric Emergency Room, Santobono s Hospital, Naples, Italy
    Environ Health Perspect 117:1780-5. 2009
    ..We conducted a multicity analysis of the relationship between air pollution and ER visits for wheezing and gastroenteric disorder in children 0-2 years of age...
  83. ncbi Early endotoxin exposure and atopy development in infants: results of a birth cohort study
    G Bolte
    University of Ulm, Department of Epidemiology, Ulm, Germany
    Clin Exp Allergy 33:770-6. 2003
    ..Exposure to endotoxin in childhood is currently discussed to protect from the development of allergic diseases...
  84. ncbi Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE
    Daan Caudri
    Department of Pediatrics Respiratory Medicine, Erasmus University, Rotterdam, The Netherlands
    Thorax 65:801-7. 2010
    ..For clinicians it remains very difficult to predict whether preschool children with symptoms suggestive of asthma will develop asthma in later childhood...
  85. pmc Maternal obesity in pregnancy and respiratory health in early childhood
    Siri E Håberg
    Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
    Paediatr Perinat Epidemiol 23:352-62. 2009
    ..3] for children with mothers who were obese during pregnancy, than for children of mothers with normal BMI. This effect was not mediated through obesity-related pregnancy complications, low birthweight, preterm birth or caesarean section...
  86. pmc Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study
    Hans Bisgaard
    The Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, and The Danish Pediatric Asthma Centre, Copenhagen University Hospital, Gentofte, Ledreborg Alle 34, DK 2820 Gentofte, Copenhagen, Denmark
    BMJ 341:c4978. 2010
    ..To study the association between wheezy symptoms in young children and the presence of bacteria in the airways...
  87. pmc Accuracy of history, wheezing, and forced expiratory time in the diagnosis of chronic obstructive pulmonary disease
    Sharon E Straus
    The Division of General Internal Medicine, University Health Network Mount Sinai Hospital, University of Toronto, Toronto, Canada
    J Gen Intern Med 17:684-8. 2002
    ..To determine the accuracy of the history and selected elements of the physical examination in the diagnosis of chronic obstructive pulmonary disease (COPD)...
  88. ncbi Rhinovirus-induced bronchiolitis and asthma development
    Tuomas Jartti
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Allergy Immunol 22:350-5. 2011
    ..RSV bronchiolitis in infancy (at the time when PCR was not available for HRV diagnosis) offers indirect evidence for the association between HRV bronchiolitis and chronic asthma...
  89. ncbi Asthma at 8 years of age in children born by caesarean section
    C Roduit
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Thorax 64:107-13. 2009
    ....
  90. pmc Effect of inhaled corticosteroids on episodes of wheezing associated with viral infection in school age children: randomised double blind placebo controlled trial
    I J Doull
    University Medicine, Southampton General Hospital
    BMJ 315:858-62. 1997
    ..To determine the effect of regular prophylactic inhaled corticosteroids on wheezing episodes associated with viral infection in school age children...
  91. ncbi Teenage asthma after severe early childhood wheezing: an 11-year prospective follow-up
    Mari K Hyvärinen
    Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
    Pediatr Pulmonol 40:316-23. 2005
    ..The risk was about 5-fold after respiratory syncytial virus-induced wheezing, and more than 10-fold after rhinovirus-induced wheezing in the present study...
  92. ncbi Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
    Sabina Illi
    Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany
    Lancet 368:763-70. 2006
    ..Unknown factors between birth and school age determine the progressive loss of pulmonary function in children with persistent asthma. We investigated the role of allergic sensitisation and allergen exposure early in life...
  93. ncbi Respiratory symptoms and smoking behaviour in Swiss conscripts
    David Miedinger
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Swiss Med Wkly 136:659-63. 2006
    ..We undertook a prospective cross sectional study to determine the prevalence of respiratory symptoms, smoking behaviour and willingness to participate in a smoking cessation program in Swiss conscripts...
  94. ncbi Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003
    K E Arden
    Sir Albert Sakzewski Virus Research Centre, Queensland Children s Medical Research Institute, Royal Children s Hospital, Queensland, Australia
    J Clin Virol 47:219-23. 2010
    ....
  95. pmc Human rhinovirus C associated with wheezing in hospitalised children in the Middle East
    E Kathryn Miller
    Department of Pediatrics, Vanderbilt University, Nashville, TN, USA
    J Clin Virol 46:85-9. 2009
    ..Few studies have investigated the disease burden and genetic diversity of human rhinoviruses (HRVs) in developing countries...
  96. pmc West Sweden Asthma Study: prevalence trends over the last 18 years argues no recent increase in asthma
    Jan Lotvall
    Department of Internal Medicine, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Respir Res 10:94. 2009
    ..Therefore, our data argues that the continued increase in asthma prevalence that has been observed over the last half century is over...
  97. ncbi Live attenuated versus inactivated influenza vaccine in infants and young children
    Robert B Belshe
    Saint Louis University Health Sciences Center, St Louis, USA
    N Engl J Med 356:685-96. 2007
    ..S. advisory bodies. To evaluate alternative vaccine approaches, we compared the safety and efficacy of intranasally administered live attenuated influenza vaccine with those of inactivated vaccine in infants and young children...
  98. ncbi The relationship between household income and childhood respiratory health in the United Kingdom
    Mara Violato
    University of Oxford, Health Economics Research Centre, Oxford, United Kingdom
    Soc Sci Med 69:955-63. 2009
    ..We argue that our evidence should inform government health and broader fiscal policies aimed at reducing health inequalities in childhood...
  99. ncbi Recurrent wheezing in the third year of life among children born at 32 weeks' gestation or later: relationship to laboratory-confirmed, medically attended infection with respiratory syncytial virus during the first year of life
    Gabriel J Escobar
    Division of Research, Systems Research Initiative and Perinatal Research Unit, Kaiser Permanente Medical Care Program, Oakland, California 94612, USA
    Arch Pediatr Adolesc Med 164:915-22. 2010
    ..To quantify the relationship between recurrent wheezing (RW) in the third year of life and respiratory syncytial virus (RSV) infection, prematurity, and neonatal oxygen exposure...
  100. pmc Relationship between socioeconomic status and asthma: a longitudinal cohort study
    R J Hancox
    Dunedin Multidisciplinary Health and Development Research Unit, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Thorax 59:376-80. 2004
    ..Most of these studies have been cross sectional in design and have relied on subjective markers of asthma such as symptoms of wheeze. Many have been unable to control adequately for potential confounding factors...
  101. ncbi Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children
    Anders Bjerg
    Obstructive Lung Disease in Northern Sweden Studies, Department of Medicine, Sunderby Central Hospital of Norrbotten, Lulea, Sweden
    Pediatrics 120:741-8. 2007
    ..Previous population-based studies have not stratified analyses by child gender and sensitization status. Our aim was to study in detail the hereditary component of childhood asthma...

Research Grants68

  1. AADRC -- Mechanisms of Virus-Induced Asthma
    James Gern; Fiscal Year: 2005
    ..It is proposed that these collaborative studies will provide new insight into mechanisms of respiratory-virus-induced asthma, the possible role of diminished IFN-gamma production in this process, and possibilities for new treatment...
  2. The Genetic Epidemiology of Asthma in Costa Rica
    JUAN CELEDON; Fiscal Year: 2005
    ..In addition, it will create a bank of phenotypic and genotypic information that will facilitate further hypothesis testing in a unique patient cohort. ..
  3. T Regulatory Cells and Childhood Asthma
    James Gern; Fiscal Year: 2008
    ..abstract_text> ..
  4. Innate Immunity and RSV Infection in Children
    Theresa Guilbert; Fiscal Year: 2007
    ..Accomplishment of these aims will allow us to begin to elucidate the immune mechanisms of the major gene-environment interactions influencing early childhood respiratory disease. ..
  5. Epidemiology of Regulatory T Cells in Pregnancy and Childhood Atopic Diseases
    Ganesa Wegienka; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  6. Prevention of chronic asthma: age 7 follow up
    MARY KLINNERT; Fiscal Year: 2005
    ..In addition, we will use the early data to identify developmental precursors for poor adherence and increased asthma morbidity at age 7. ..
  7. BETA-2 ADRENERGIC RECEPTOR POLYMORPHISMS AND ASTHMA
    Augusto Litonjua; Fiscal Year: 2002
    ..End of Abstract) ..
  8. HOW MUCH DOES SHE REALLY DRINK? AN HMO INTERVENTION
    GABRIEL ESCOBAR; Fiscal Year: 2003
    ..abstract_text> ..
  9. CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMA
    ROBERT LEMANSKE; Fiscal Year: 2001
    ..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
  10. Gene by Environment Interactions in Asthma and Allergy
    Augusto Litonjua; Fiscal Year: 2009
    ..Blood for genetic material is currently being collected on the two cohorts, and endotoxin will be measured from stored, frozen house dust. ..
  11. Airway as Target Organ in Infants with Atopic Dermatitis
    Robert Tepper; Fiscal Year: 2008
    ..Specific Aim # 2: Evaluate whether the presence of phenotypic characteristics of the asthmatic airway identifies infants and toddlers that develop clinical asthma by 5 years of age. [unreadable] [unreadable]..
  12. ASTHMA AND INTERVENTIONS IN THE EMERGENCY DEPARTMENT
    Robert Strunk; Fiscal Year: 2002
    ..The intent to treat model will be used, as primary outcome can be obtained after consent even if not contact cannot be made at 2 week and 6 month phone calls. ..
  13. Treatment of Severe Persistent Asthma
    ROBERT LEMANSKE; Fiscal Year: 2007
    ..abstract_text> ..
  14. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
  15. GROWTH OF AIRWAYS AND LUNG PARENCHYMA IN NORMAL INFANTS
    Robert Tepper; Fiscal Year: 2009
    ..abstract_text> ..
  16. Epidemiology of asthma: risk and prognosis in a cohort from birth to adolescence
    Syed Hasan Arshad; Fiscal Year: 2010
    ..Our work brings together a multidisciplinary research team with a proven record of collaboration and expertise in respiratory medicine, allergy and immunology, epidemiology, genetics, and biostatistics. ..
  17. CARE Network--St. Louis Center
    Robert Strunk; Fiscal Year: 2008
    ..End of abstract.) [unreadable] [unreadable]..
  18. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
  20. Prospective Study of Dietary Factors, BMI, and Risk of Asthma in Children
    Carlos Camargo; Fiscal Year: 2008
    ..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of asthma. [unreadable] [unreadable] [unreadable] [unreadable]..
  21. CARE Network - Madison Clinical Center
    ROBERT LEMANSKE; Fiscal Year: 2008
    ..abstract_text> ..
  22. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  23. Longitudinal Lung Function Changes--Aging/Genetics/Risk
    Augusto Litonjua; Fiscal Year: 2008
    ..The results of this proposal will shed light on potential mechanisms that affect lung function decline in aging. ..
  24. Vitamin D in Obstructive Lung Diseases
    Augusto Litonjua; Fiscal Year: 2008
    ..Additionally, supplementation with vitamin D can be implemented in cost-effective population-based programs to prevent the development of, and treat these disorders. [unreadable] [unreadable] [unreadable]..
  25. Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary Embolism
    Carlos Camargo; Fiscal Year: 2008
    ..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
  26. ASTHMA CLINICAL RESEARCH NETWORK
    ROBERT LEMANSKE; Fiscal Year: 2002
    ....
  27. Risk Factors Accounting for Neighborhood Differences in Asthma Prevalence
    Matthew S Perzanowski; Fiscal Year: 2010
    ..Aim 3. We hypothesize that among children sensitized to at least one allergen (i.e., atopic), those who live in a HAPN will be more likely to have asthma than those who live in an LAPN. ..
  28. CHEMOKINE BIOMARKERS OF DIISOCYANATE OCCUPATIONAL ASTHMA
    David Bernstein; Fiscal Year: 2002
    ..abstract_text> ..
  29. Effects of Light at Night on Circadian System in Nurses
    Eva Schernhammer; Fiscal Year: 2008
    ..abstract_text> ..
  30. Antibiotics in Infancy-Risk Factor for Childhood Asthma
    Dennis Ownby; Fiscal Year: 2002
    ..This new analysis will allow a much more rigorous examination of the possible relationship between early antibiotic use and asthma in a population of American children. ..
  31. HUMAN MONOCLONAL ANTIBODIES THAT NEUTRALIZE VACCINIA
    James Crowe; Fiscal Year: 2002
    ..In summary, this work will yield a safe and effective immunotherapeutic strategy for treatment of vaccinia complications. ..
  32. Aspartame Intake and the Risk of Cancer
    Eva Schernhammer; Fiscal Year: 2008
    ..Our results may help decision-makers formulate guidelines and direct future aspartame studies. Even a null finding would be important in this context. [unreadable] [unreadable] [unreadable]..
  33. PHONATION AND PHONATORY CONTROL IN VOCAL TREMORS
    Marshall Smith; Fiscal Year: 2002
    ..The experimental phase consists of studies of neuromuscular and respiratory input to the larynx. This information about vocal tremor will be applied to model simulations with the use of physiological signals as input model parameters. ..
  34. Respiratory Syncytial Virus Nanoparticle Vaccines
    James Crowe; Fiscal Year: 2008
    ..The development of a new technology for vaccination using nanoparticles also could have wide impact, since such a vaccine technology might be useful in developing vaccines against other infections. [unreadable] [unreadable] [unreadable]..
  35. Influence of Genetics and Air Pollution Exposures on Birth Outcomes
    Kathleen Mortimer; Fiscal Year: 2008
    ..Study designs that allow for cost-efficient participant recruitment and sample collection would guide future cohort studies of children's environmental health. [unreadable] [unreadable] [unreadable]..
  36. Role of Mouse Allergen in Childhood Asthma
    Wanda Phipatanakul; Fiscal Year: 2007
    ..This will help her translate knowledge gained from her research into direct community benefit. [unreadable] [unreadable]..
  37. GENETIC REGULATION OF IMMUNE MATURATION IN ASTHMA
    Fernando Martinez; Fiscal Year: 2001
    ....
  38. Developing and Evaluating New Approaches to Youth Agricultural Injury Prevention
    John Wilkins; Fiscal Year: 2009
    ..5. Relying on the PEM data, quantify the risk of CAI among participating youth. ..
  39. Molecular epidemiologic identification of pneumococcal tissue specific genes
    MELINDA MARY PETTIGREW; Fiscal Year: 2010
    ..A greater understanding of the genetic factors that influence the virulence potential of pneumococcal clones is critical to our ability to develop effective methods to control, prevent, and treat these important infections. ..
  40. Impact of Violence on Obesity & Reproductive Axes in Youth
    Rosalind J Wright; Fiscal Year: 2010
    ..In addition, salivary cortisol rhythms will be examined in relation to history of violence exposure and as a mediator between violence exposure and the proposed outcomes in a subsample (n=1200). ..
  41. ONTOGENY OF RSV-SPECIFIC B CELL RESPONSES IN HUMANS
    James Crowe; Fiscal Year: 2001
    ..The data from this work will direct decisions about the best vaccine strategy to use against RSV in neonates, and will delineate basic mechanisms of the ontogeny of B-cell repertoire diversity in humans. ..
  42. Effects of Long-Term Low Level Hydrogen Sulfide Exposure
    Michael N Bates; Fiscal Year: 2010
    ..Study results will either confirm the adequacy of current U.S. occupational and environmental exposure standards for H2S or provide evidence that they are insufficiently health protective. ..
  43. CARE Network-UCSD Clinical Center
    Robert Zeiger; Fiscal Year: 2008
    ..abstract_text> ..
  44. Immunomodulation on the Nanoscale (RMI)
    James Crowe; Fiscal Year: 2004
    ..Immunology and infectious diseases. 2. Materials science, especially nanoparticles, nanowires, and nanofluidics. 3. Instrumented platforms for cellular imaging and control. 4. Biocomputing. ..
  45. Pet Exposure, Allergy and Early Asthma in the Inner-City
    Matthew Perzanowski; Fiscal Year: 2005
    ..3) Determine whether pet allergen exposure in an inner-city community is associated with early predictors of allergic disease and asthma including persistent wheeze, doctor diagnosed eczema and asthma symptoms. ..
  46. Human T Cells Responses to RSV
    James Crowe; Fiscal Year: 2006
    ..abstract_text> ..
  47. Ventilation Improves Lung Physiology and Biology
    Bela Suki; Fiscal Year: 2006
    ..abstract_text> ..
  48. UVA Asthma and Allergic Diseases Center
    Thomas Platts Mills; Fiscal Year: 2005
    ..Understanding the mechanisms involved is essential for defining new approaches to treatment and prevention and also for explaining the increasing prevalence of asthma. ..
  49. Racial Disparities in Diabetes in the US and the UK
    Arch Mainous; Fiscal Year: 2005
    ..abstract_text> ..
  50. Human Antibody Responses to Rotavirus
    James Crowe; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Adherence to the NAGCAT and Injury Risk Reduction
    John Wilkins; Fiscal Year: 2005
    ..5. Identify parental characteristics and attitudes that most strongly predict high compliance / conformity with the NAGCAT. ..
  52. Gene Discovery for Pneumococcal Otitis Media
    Melinda Pettigrew; Fiscal Year: 2005
    ..Discovery of additional factors involved in streptococcal OM will facilitate the development of new strategies for the control and prevention of this important disease. ..
  53. RESPONSES TO RSV AND ALLERGENS AS ANTECEDENTS OF ASTHMA
    Marilyn Halonen; Fiscal Year: 2002
    ....
  54. Medical workplace exposures, atopy and asthma in nurses
    Maria Mirabelli; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  55. CHRONIC LIFE STRESS AND INCIDENT ASTHMA IN ADULT WOMEN
    Rosalind Wright; Fiscal Year: 2003
    ..To our knowledge, this would be the first large-scale (N=64,000) longitudinal study of the association between a specific chronic life stressor (i.e., violence) and the incidence of asthma in adult women. ..
  56. Alphavirus-based Vaccine for Prevention of MPV Infection
    James Crowe; Fiscal Year: 2008
    ..The consortium submitting this application brings together an experienced investigator group with expertise in pneumovirus and alphavirus virology, immunology, and vaccine development. ..
  57. Microbial Innate Immunity In Asthma Pathogenesis
    Marilyn Halonen; Fiscal Year: 2008
    ..abstract_text> ..
  58. CARE Network - Tucson Clinical Center
    Fernando Martinez; Fiscal Year: 2008
    ..abstract_text> ..
  59. CHROMOSOME 5Q GENE VARIANTS AND ASTHMA-RELATED TRAITS
    Fernando Martinez; Fiscal Year: 2004
    ..This will allow to better understand the genetic influence that determine asthma risk. ..
  60. Human Laryngeal Pacing for Aspiration
    Michael Broniatowski; Fiscal Year: 2005
    ..abstract_text> ..
  61. Quality of Life in patients with severe Cystic Fibrosis
    Christopher Goss; Fiscal Year: 2007
    ....
  62. IL8 and GATA3-mediated Pathways in Asthma Exacerbations
    Fernando Martinez; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable]..
  63. Environmental Effects on Lung Function in Cystic Fibrosis Patients
    Christopher Goss; Fiscal Year: 2008
    ..Our proposal will also enhance our understanding of lung growth in CF and represents the initial phase of a program to understand environmental effects on CF lung disease. [unreadable] [unreadable] [unreadable]..
  64. INNATE IMMUNITY IN HEART, LUNG, AND BLOOD DISEASE
    Fernando Martinez; Fiscal Year: 2003
    ..abstract_text> ..
  65. Peer Education in Pregnancy Study
    Victoria Persky; Fiscal Year: 2006
    ..Results of this study will assist in elucidating the etiologic pathway by which asthma develops early in life, as well as assist in the development of effective intervention programs. ..
  66. ASSESSMENT OF BIOLOGICAL/SOCIAL RISK IN PRETERM INFANTS
    Diane Holditch Davis; Fiscal Year: 2001
    ....