Genomes and Genes
Summary: A morbid condition of ANOXIA caused by the reduced available oxygen at high altitudes.
Publications275 found, 100 shown here
- Acute mountain sickness: influence of susceptibility, preexposure, and ascent rateMichael Schneider
Department of Internal Medicine, Division of Sports Medicine, University Hospital Heidelberg, Germany
Med Sci Sports Exerc 34:1886-91. 2002..We examined the interaction of various established risk factors for acute mountain sickness (AMS) in a setting relevant for mountaineering and trekking...
- Intraocular pressure during a very high altitude climbMartina M Bosch
Department of Ophthalmology, University Hospital, Zurich, Switzerland
Invest Ophthalmol Vis Sci 51:1609-13. 2010..Reports on intraocular pressure (IOP) changes at high altitudes have provided inconsistent and even conflicting..
- Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlandersCynthia M Beall
Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
Proc Natl Acad Sci U S A 107:11459-64. 2010..Whichever of these explanations is correct, the evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants...
- Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatmentJoshua O Stream
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
Wilderness Environ Med 19:293-303. 2008....
- Consensus statement on chronic and subacute high altitude diseasesFabiola Leon-Velarde
Cayetano Heredia University IIA, Department of Biological and Physiological Sciences, Oxygen Transport Laboratory, Lima 100, Peru
High Alt Med Biol 6:147-57. 2005..Most of the cases of high altitude diseases are preventable if on-site personnel identify the condition and implement appropriate care...
- Prevalence of acute mountain sickness in the Eastern AlpsKlemens Mairer
Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria
High Alt Med Biol 10:239-45. 2009..Consideration of easily modifiable risk factors such as individual exertion and water intake could markedly reduce AMS and contribute to the enjoyment of mountaineering...
- The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sicknessDante Penaloza
Department of Medicine, Faculty of Medicine, University Cayetano Heredia, Lima, Peru
Circulation 115:1132-46. 2007..Chronic mountain sickness is a public health problem in the Andean mountains and other mountainous regions around the world. Therefore, dissemination of preventive and therapeutic measures is essential...
- Autonomic control of the cardiovascular system during acclimatization to high altitude: effects of sildenafilJérémy Cornolo
Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, 93017 Bobigny, France
J Appl Physiol 97:935-40. 2004..Sil had no deleterious effects on the cardiovascular response to high-altitude exposure and its control by the autonomic nervous system...
- Gene polymorphisms and high-altitude pulmonary edema susceptibility: a 2011 updateYongjun Luo
Department of High Altitude Diseases, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, PR China
Respiration 84:155-62. 2012..The goal of this review article is to summarize the current literature and to define the outstanding areas of research that need to be explored to advance our ability to predict when HAPE will occur...
- Prevention and treatment of high-altitude pulmonary edemaMarco Maggiorini
Intensive Care Unit, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
Prog Cardiovasc Dis 52:500-6. 2010..If progressive high altitude acclimatization would not be possible, prophylaxis with nifedipine or tadalafil for long sojourns at high altitude or dexamethasone for a short stay of less then 5 days should be recommended...
- Role of hypobaria in fluid balance response to hypoxiaJack A Loeppky
Cardiology Section, VA Medical Center, Albuquerque, New Mexico
High Alt Med Biol 6:60-71. 2005..The fluid retention at ALT in AMS-susceptible subjects appears related to a synergistic interaction involving reduced P(B) and ADH and ALDO...
- Appetite at "high altitude" [Operation Everest III (Comex-'97)]: a simulated ascent of Mount EverestM S Westerterp-Plantenga
Maastricht University, Maastricht, The Netherlands
J Appl Physiol (1985) 87:391-9. 1999..We conclude that exposure to hypobaric hypoxia per se appears to be associated with a change in the attitude toward eating and with a decreased appetite and food intake...
- Oximetry, heart rate variability, and the diagnosis of mild-to-moderate acute mountain sicknessMichael S Koehle
School of Human Kinetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Eur J Emerg Med 17:119-22. 2010..In conclusion, in patients with SpO2 of 86% or more at 4380 m or higher, the likelihood of AMS is low. Diastolic blood pressure correlated with AMS severity, whereas heart rate variability was not useful in the diagnosis of AMS...
- Who are more at risk for acute mountain sickness: a prospective study in Qinghai-Tibet railroad construction workers on Mt. TanggulaTian Yi Wu
Physiological Research Group of the Ministry of Railway, High Altitude Medical Research Institute, Xining, Qinghai 810012, China
Chin Med J (Engl) 125:1393-400. 2012..Tanggula during the construction of the Qinghai-Tibet railroad. This study explored the risk factors predisposing workers to developing AMS and attempted to develop more effective ways of preventing and treating AMS...
- High altitude sleep disturbances monitored by actigraphy and polysomnographyYvonne Nussbaumer-Ochsner
Pulmonary Division and Sleep Disorders Center, University Hospital of Zurich, and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
High Alt Med Biol 12:229-36. 2011..Data on sleep at altitude are scant due to the limited availability of polysomnography. Therefore, we investigated whether actigraphy might serve as a simple tool for monitoring sleep during altitude field studies...
- High altitude headache. A prospective study of its clinical characteristicsM Serrano-Dueñas
Movement Disorders Clinic, Neurological Service, Hospital Carlos Andrade Marín and, Medicine Faculty, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador
Cephalalgia 25:1110-6. 2005..8%; concurrent symptoms referred to, anorexia 26.8%, irritability 26.5%, and finally pessimism and anxiety feelings 33.2 and 29.5%, respectively. We believe that elements provided by us must lead to a new official AH diagnosis criterion...
- Acute mountain sickness in Iranian trekkers around Mount Damavand (5671 m) in IranVahid Ziaee
Department of Pediatrics, Sport Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
Wilderness Environ Med 14:214-9. 2003..Many trekkers up Mount Damavand run the risk of developing acute mountain sickness (AMS); however, not much is documented concerning the incidence of AMS and its related factors within this population...
- Physiology and pathophysiology with ascent to altitudeBiff F Palmer
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Am J Med Sci 340:69-77. 2010..The most common clinical manifestations of altitude illness are acute mountain sickness, high altitude pulmonary edema, and high altitude cerebral edema...
- The cerebral effects of ascent to high altitudesMark H Wilson
Centre for Altitude, Space and Extreme Environment Medicine, University College London, London, UK
Lancet Neurol 8:175-91. 2009..The effects of hypobaric hypoxia might also provide new insights into the understanding of hypoxia in the clinical setting...
- Cerebrovascular responses to altitudeJulien V Brugniaux
Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
Respir Physiol Neurobiol 158:212-23. 2007..Existing gaps in our knowledge of CBF and altitude, and areas of future investigation include effects of longer exposures, intermittent hypoxia, and gender differences in the CBF responses to altitude...
- Physiological aspects of high-altitude pulmonary edemaPeter Bartsch
Department of Internal Medicine VII, Division of Sports Medicine, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
J Appl Physiol (1985) 98:1101-10. 2005..The combination of high flow at higher pressure results in pressures, which exceed the structural and dynamic capacity of the alveolar capillary barrier to maintain normal alveolar fluid balance...
- Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factorErik R Swenson
Pulmonary and Critical Care Section, S 111 Pulm, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
JAMA 287:2228-35. 2002....
- High-altitude illnessBuddha Basnyat
Nepal International Clinic, Kathmandu, Nepal Himalayan Rescue Association, Kathmandu, Nepal
Lancet 361:1967-74. 2003..Despite investigation of other agents, acetazolamide remains the preferred drug for preventing AMS. The next few years are likely to see many advances in the understanding of the causes and management of high-altitude illness...
- General introduction to altitude adaptation and mountain sicknessP Bartsch
Department of Internal Medicine, Division of Sports Medicine, Medical University Clinic, Heidelberg, Germany heidelberg de
Scand J Med Sci Sports 18:1-10. 2008..A new classification of altitude levels based on the effects on performance and well-being is proposed and an overview given over the various modalities using hypoxia and altitude for improvement of performance...
- Reduced oxygen due to high-altitude exposure relates to atrophy in motor-function brain areasM Di Paola
Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy
Eur J Neurol 15:1050-7. 2008..The present study was designed to explore the effects of high-altitude exposure using a quantitative MRI technique, voxel-based morphometry...
- High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive proteinG Hartmann
Ludwig Maximilians University, Munich, Germany
Cytokine 12:246-52. 2000..The existence and the kinetics of high altitude-induced cytokines found in this study support the hypothesis that inflammation is involved in the development of HAPO...
- New insights in the pathogenesis of high-altitude pulmonary edemaUrs Scherrer
Department of Internal Medicine and the Botnar Center for Extreme Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Prog Cardiovasc Dis 52:485-92. 2010....
- Human genetic adaptation to high altitudeL G Moore
Department of Anthropology, University of Colorado at Denver, Denver CO 80217, USA
High Alt Med Biol 2:257-79. 2001....
- High altitude pulmonary edema: a pressure-induced leakChristoph Dehnert
Medical University Clinic, Department of Internal Medicine, Div of Sports Medicine, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
Respir Physiol Neurobiol 158:266-73. 2007..Lower levels of exhaled NO in hypoxia before and during HAPE suggest that this abnormality also occurs in the lungs and polymorphisms of the eNOS gene are associated with susceptibility to HAPE in the Indian and Japanese population...
- Normo or hypobaric hypoxic tests: propositions for the determination of the individual susceptibility to altitude illnessesGustave Savourey
Département des Facteurs Humains, Pôle tolérance climatique et vêtement, Centre de Recherches du Service de Sante des Armees, BP 87 38702, La Tronche Cedex, France
Eur J Appl Physiol 100:193-205. 2007..47 + 0.104PetO2(hPa)-0.68CpO2 (%), (R = 0.77, P = 0.001); and AMSmean = 3.91 + 0.059Deltaf + 0.438HCR-0.135CpO2 (R = 0.71, P = 0.017)...
- Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patternsGuoqiang Xing
Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
PLoS ONE 3:e2342. 2008....
- Changes of hematocrit and hemoglobin concentration in the cold Himalayan environment in dependence on total body fluidMarkus Tannheimer
Department of Visceral and Thoracic Surgery, Armed Forces Hospital Ulm, Ulm, Germany
Sleep Breath 14:193-9. 2010..Therefore, the influence of water distribution on hemoglobin (Hb) and hematocrit (Hct) values during a long-term exposure at high altitude was investigated...
- KGF-2 targets alveolar epithelia and capillary endothelia to reduce high altitude pulmonary oedema in ratsJun She
Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
J Cell Mol Med 16:3074-84. 2012..Thus, KGF-2 may represent a potential drug candidate for the prevention of HAPE...
- Susceptibility to high altitude pulmonary oedema: role of ACE and ET-1 polymorphismsR Charu
Thorax 61:1011-2. 2006
- Risk factors for high-altitude headache in mountaineersMartin Burtscher
Department of Sport Science, University of Innsbruck, Innsbruck, Austria
Cephalalgia 31:706-11. 2011..The aim was to identify most relevant risk factors of high-altitude headache within a broad mountaineering population through a prospective, observational, rater-blinded study...
- The role of oxygen-increased respirator in humans ascending to high altitudeGuanghao Shen
Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi, 710049, PR China
Biomed Eng Online 11:49. 2012..Many instruments have been developed to treat mild cases of AMS. However, long-lasting and portable anti-hypoxia equipment for individual is not yet available...
- Blood pressure responses in young adults first exposed to high altitude for 12 months at 3550 mPatricia Siques
Institute of Health Studies, Universidad Arturo Prat, Iquique, Chile
High Alt Med Biol 10:329-35. 2009..Further, a sustained high DBP should be a matter of epidemiological concern and emphasizes the need for BP monitoring among young lowlanders exposed to high altitude...
- The body weight loss during acute exposure to high-altitude hypoxia in sea level residentsRi Li Ge
Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
Sheng Li Xue Bao 62:541-6. 2010....
- Reduced autonomic activity during stepwise exposure to high altitudeK Sevre
Department of Cardiology, , Oslo, Norway
Acta Physiol Scand 173:409-17. 2001..1 +/- 6%, P = 0.03). Diastolic blood pressure, HR and adrenaline displayed similar tendencies. We conclude that a transient reduction in parasympathetic and sympathetic activity was demonstrated during stepwise exposure to high altitude...
- Alterations in autonomic nervous control of heart rate among tourists at 2700 and 3700 m above sea levelM Kanai
Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi, Japan
Wilderness Environ Med 12:8-12. 2001..The sympathetic nervous system was dominant to the parasympathetic at 3700 m. These alterations in the autonomic nervous system might play some role in physical fitness at high altitudes...
- Epidemiology of acute mountain sickness on Jade Mountain, Taiwan: an annual prospective observational studyShih Hao Wang
Department of Emergency Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
High Alt Med Biol 11:43-9. 2010..The overall presentation of AMS was similar to that on other major world mountains...
- Everest or bust: a cross sectional, epidemiological study of acute mountain sickness at 4243 meters in the HimalayasB Basnyat
Himalayan Rescue Association Nepal International Clinic Patan Hospital, Nepal
Aviat Space Environ Med 70:867-73. 1999....
- Endothelin-1 gene variants and levels associate with adaptation to hypobaric hypoxia in high-altitude nativesCharu Rajput
Institute of Genomics and Integrative Biology, Delhi 110 007, India Centre for Biotechnology, Hamdard University, New Delhi 110 062, India
Biochem Biophys Res Commun 341:1218-24. 2006..Interaction between these alleles and association with lower ET-1 levels strengthen their association with high-altitude adaptation. Presence of such alleles in sojourners may help in acclimatization...
- Pathophysiological significance of peroxidative stress, neuronal damage, and membrane permeability in acute mountain sicknessDamian M Bailey
Department of Physiology, University of Glamorgan, Pontypridd, South Wales, UK
J Appl Physiol (1985) 96:1459-63. 2004..The pathophysiological significance of increased sarcolemmal membrane permeability and inflammatory response, either as a cause or epiphenomenon of AMS and/or high-altitude pulmonary edema, remains to be elucidated...
- Pulmonary extravascular fluid accumulation in recreational climbers: a prospective studyGeorge Cremona
Unit of Respiratory Medicine, San Raffaele University Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
Lancet 359:303-9. 2002..High altitude pulmonary oedema (HAPE) that is severe enough to require urgent medical care is infrequent. We hypothesised that subclinical HAPE is far more frequent than suspected during even modest climbs of average effort...
- Oxidative stress and erythropoietin response in altitude exposureHsien Hao Huang
Department of Emergency Medicine, Taipei VeteransGeneral Hospital, College of Medicine, NationalYang Ming University, Taipei, Taiwan
Clin Invest Med 31:E380-5. 2008..We hypothesized that the altitude-oxidative stress and EPO response would be associated with the presence or absence of acute mountain sickness (AMS) in subjects exposed at high altitude...
- Sleep architecture changes during a trek from 1400 to 5000 m in the Nepal HimalayaPamela L Johnson
David Read Laboratory, Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
J Sleep Res 19:148-56. 2010..Periodic breathing was commonplace at all altitudes, and while associated with increases in arousal indices, did not have any apparent effect on sleep architecture...
- Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHAIT)Jeffrey H Gertsch
Department of Internal Medicine, Maricopa Medical Center, 2601 E Roosevelt Avenue number O D 10, Phoenix, AZ 85008, USA
BMJ 328:797. 2004..To evaluate the efficacy of ginkgo biloba, acetazolamide, and their combination as prophylaxis against acute mountain sickness...
- Genetic contribution of the endothelial nitric oxide synthase gene to high altitude adaptation in sherpasYunden Droma
Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
High Alt Med Biol 7:209-20. 2006..The nitric oxide metabolites (NO( x )) in serum vary individually, thus it is not a reliable indicator for endogenous nitric oxide production...
- The physiologic basis of high-altitude diseasesJohn B West
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
Ann Intern Med 141:789-800. 2004
- New insights into ocular blood flow at very high altitudesMartina M Bosch
Department of Opthamology, University Hospital, Zurich, Switzerland
J Appl Physiol (1985) 106:454-60. 2009..We demonstrate that sojourns at high altitudes trigger distinct behavior of retinal and choroidal blood flow. Increase in retinal but not in choroidal blood flow correlated with the occurrence of AMS-related symptoms...
- Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxiaJim Hansen
Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
J Physiol 546:921-9. 2003..Surprisingly, chemoreflex activation by hypoxia and baroreflex deactivation by dehydration together could account for only a small part of this response, leaving the major underlying mechanisms unexplained...
- Frontiers of hypoxia research: acute mountain sicknessR C Roach
New Mexico Resonance, Box 343, Montezuma, NM 87731, USA
J Exp Biol 204:3161-70. 2001..We believe that an examination of the responses of the central nervous system to acute hypoxia will reveal important new pathophysiological processes that may help explain AMS and HACE...
- Sleep at high altitudeJohn V Weil
Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, 4200 East NinthAvenue, Denver 80262, USA
High Alt Med Biol 5:180-9. 2004..Interventions that improve sleep quality at high altitude include acetazolamide and benzodiazepines...
- Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier functionD M Bailey
Neurovascular Research Laboratory, Faculty of Health, Science and Sport, University of Glamorgan, Mid Glamorgan, South Wales CF37 1DL, UK
J Physiol 587:73-85. 2009..In conclusion, these findings suggest that AMS is associated with altered redox homeostasis and disordered CA independent of barrier disruption...
- Effects of high altitude exposure on cerebral hemodynamics in normal subjectsAurélie van Osta
Laboratory of Physiology, Faculty of Medicine, Free University of Brussels, Belgium
Stroke 36:557-60. 2005..If so, AMS could result from an alteration of dynamic autoregulation of cerebral blood flow resulting in overperfusion of capillaries and vasogenic cerebral edema...
- Alternations of heart rate variability at lower altitude in the predication of trekkers with acute mountain sickness at high altitudeHsien Hao Huang
Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R O C
Clin J Sport Med 20:58-63. 2010..To determine the change and relationship of spectral components of heart rate variability (HRV) measurements in subjects with or without acute mountain sickness (AMS) at both low and high altitude...
- Chronic mountain sickness on the Qinghai-Tibetan plateauTian Yi Wu
High Altitude Medical Research Institute, Xining 810012, China
Chin Med J (Engl) 118:161-8. 2005
- Effect of hypohydration and altitude exposure on aerobic exercise performance and acute mountain sicknessJohn W Castellani
Thermal and Mountain Medicine Division, U S Army Research Institute of Environmental Medicine, 42 Kansas St, Natick, MA 01760 5007, USA
J Appl Physiol (1985) 109:1792-800. 2010..07). In conclusion, hypohydration at 3,048 m 1) degrades aerobic performance in an additive manner with that induced by ALT; and 2) did not appear to increase the prevalence/severity of AMS symptoms...
- Awareness, prevalence, medication use, and risk factors of acute mountain sickness in tourists trekking around the Annapurnas in Nepal: a 12-year follow-upSamuel Gaillard
Département de médecine communautaire, Hopitaux Universitaires, Geneva, Switzerland
High Alt Med Biol 5:410-9. 2004..In conclusion, in 1998 as compared to 1986, trekkers were older, climbed more slowly, had better awareness of altitude illness, used more medication, and suffered less from AMS...
- Who should not go high: chronic disease and work at altitude during construction of the Qinghai-Tibet railroadTian Yi Wu
Physiological Research Group of the Ministry of Railroad, P R China
High Alt Med Biol 8:88-107. 2007....
- Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphologicalDamian Miles Bailey
Neurovascular Research Laboratory, Faculty of Health, Science and Sport, University of Glamorgan, Pontypridd, CF37 1DL, South Wales, UK
Cell Mol Life Sci 66:3583-94. 2009..This has led to a re-evaluation of the relevant pathogenic events with a specific focus on free radicals and their interaction with the trigeminovascular system...
- Hypoxic ventilatory response, ventilation, gas exchange, and fluid balance in acute mountain sicknessPeter Bartsch
Department of Internal Medicine, Division of Sports Medicine, Medical University Clinic, Heidelberg, Germany
High Alt Med Biol 3:361-76. 2002....
- Body temperature, autonomic responses, and acute mountain sicknessJack A Loeppky
Cardiology Section 111B, VA Medical Center, Albuquerque, NM, USA
High Alt Med Biol 4:367-73. 2003..Greater hypoxic vasodilation and elevated HR in AMS in the absence of other changes suggest that augmentation of beta-adrenergic tone may be involved in early AMS pathophysiology...
- Effects of hypobaric hypoxia on cerebral autoregulationAndrew W Subudhi
Altitude Research Center, University of Colorado at Denver, School of Medicine, Denver, CO, USA
Stroke 41:641-6. 2010..This investigation evaluated relationship between CA and AMS over 9 hours of hypobaric hypoxia...
- Efficacy of low-dose acetazolamide (125 mg BID) for the prophylaxis of acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trialBuddha Basnyat
Nepal International Clinic, Himalayan Rescue Association
High Alt Med Biol 4:45-52. 2003..We concluded that acetazolamide 125 mg twice daily was effective in decreasing the incidence of AMS in this Himalayan trekking population...
- Work at high altitude and oxidative stress: antioxidant nutrientsE W Askew
Division of Foods and Nutrition, University of Utah, 250 South 1850 East Room 239 N HPR, Salt Lake City, UT 84112, USA
Toxicology 180:107-19. 2002..antioxidant supplementation is when does oxidative stress become potentially damaging enough to merit antioxidant therapy and conversely, what degree of oxidative stress is necessary to foster the adaptive response of altitude exposure?..
- Optic nerve sheath diameter correlates with the presence and severity of acute mountain sickness: evidence for increased intracranial pressurePeter J Fagenholz
Himalayan Rescue Association, Pheriche Clinic, Spring Season 2006, Nepal
J Appl Physiol (1985) 106:1207-11. 2009..84, P < 0.001). Optic nerve sheath diameter, a proxy for intracranial pressure, is associated with the presence and severity of AMS...
- Going high with preexisting neurological conditionsRalf W Baumgartner
Department of Neurology, University Hospital Zurich, Switzerland
High Alt Med Biol 8:108-16. 2007..These recommendations are not based on the results of controlled randomized trials, but mainly on case reports, pathophysiological considerations, and extrapolations from the low altitude situation...
- Acute normobaric hypoxia stimulates erythropoietin releaseRichard W A Mackenzie
Chelsea School Research Center, University of Brighton, Eastbourne, United Kingdom
High Alt Med Biol 9:28-37. 2008..1 mU/mL (9.8%). It was concluded that an acute bout of hypoxia, has the capacity to elevate plasma EPO. This study also demonstrates that the increase in EPO accumulation was 2 times greater than the calculated measurement of error...
- Gene expression, autonomic function and chronic hypoxia:lessons from the AndesOtto Appenzeller
New Mexico Health Enhancement and Marathon Clinics Research Foundation, Albuquerque, NM 87122 1424, USA
Clin Auton Res 16:217-22. 2006..These changes may support the physiologic alterations induced by the ambient hypoxia at altitude and impact organism survival. They also suggest therapeutic strategies for autonomic and neurodegenerative diseases at sea level...
- Obesity: associations with acute mountain sicknessGe Ri-Li
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA
Ann Intern Med 139:253-7. 2003..Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been studied prospectively...
- Platelet count and function at high altitude and in high-altitude pulmonary edemaT Lehmann
Dept of Internal Medicine, Kantonsspital, CH 7000 Chur, Switzerland
J Appl Physiol 100:690-4. 2006..These effects are, however, not more pronounced in individuals with a history of HAPE or actually suffering from HAPE than in controls and therefore may not be a pathophysiological mechanism of HAPE...
- Recompression therapy of mountain sicknessDubravko Marković
General Hospital Pula, Pula, Croatia
Arh Hig Rada Toksikol 53:3-6. 2002..Portable hyperbaric chamber is recommended for the treatment of severe cases of acute mountain sickness, as well as for risky descent to lower altitudes...
- Ginkgo biloba and acetazolamide prophylaxis for acute mountain sickness: a randomized, placebo-controlled trialTony Chow
Department of Emergency Medicine, Loma Linda University Medical Center and Children s Hospital, Loma Linda, CA 92354, USA
Arch Intern Med 165:296-301. 2005..We performed a randomized, placebo-controlled trial of acetazolamide vs Ginkgo biloba for AMS prophylaxis...
- Lack of evidence for association of high altitude pulmonary edema and polymorphisms of the NO pathwayJohanna Weiss
Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
High Alt Med Biol 4:355-66. 2003..The results of this study suggest that none of these genetic variants plays a substantial role in the pathogenesis of HAPE in Caucasians, but does not exclude epistatic effects that might still involve the genetic systems studied here...
- The Qinghai-Tibetan plateau: how high do Tibetans live?T Wu
Department of Physiology and Mountain Sickness, High Altitude Medical Research Institute, Xining, Qinghai, P R China
High Alt Med Biol 2:489-99. 2001..Thus the apparently low incidence of CMS in Tibetans cannot be ascribed to "geographic differences." We propose that the genetic adaptation to hypoxia that has occurred in Tibetans is of importance in CMS...
- High-altitude headacheMarcos Serrano-Dueñas
Carlos Andrade Marin Hospital, Movement Disorders Unit, Neurological Service, Quito, Ecuador
Expert Rev Neurother 7:245-8. 2007..These are neurogenic problems secondary to hypoxia caused by hypobarism and, in all events, have a common denominator: hypoxia and a fundamental white organ, the brain...
- Angiotensin converting enzyme insertion allele in relation to high altitude adaptationM A Qadar Pasha
Functional Genomics Unit, Centre for Biochemical Technology, Delhi, India
Ann Hum Genet 65:531-6. 2001..The I allele frequency was 0.72 in the MLLs, 0.67 in the HLs and 0.55 in the LLs. Polymorphism study suggested that the II genotype could be associated with altitude adaptation, which might influence physical efficiency...
- High-altitude retinopathy and optical coherence tomography findingsRajeev K Seth
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA
Semin Ophthalmol 25:13-5. 2010..To report the case and OCT findings of a case of high altitude retinopathy (HAR)...
- Do changes in lung function predict high-altitude pulmonary edema at an early stage?Oliver Senn
Pulmonary Division, University Hospital of Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Med Sci Sports Exerc 38:1565-70. 2006..Therefore, we investigated the time course of pulmonary function in relation to hemodynamics and clinical symptoms in mountaineers ascending rapidly to high altitude...
- Pharmacologic prophylaxis for acute mountain sickness: a systematic shortcut reviewRawle A Seupaul
Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Ann Emerg Med 59:307-317.e1. 2012..Since 2000, a number of other agents have been reported to be beneficial. This EBEM review evaluates the most current evidence on this topic...
- Migraines and high-altitude headachesJacky A Miller
Wilderness Environ Med 14:286-7. 2003
- Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness?Damian M Bailey
Neurovascular Research Laboratory, Faculty of Health, Science and Sport, University of Glamorgan, Mid Glamorgan, United Kingdom
Am J Physiol Regul Integr Comp Physiol 297:R1283-92. 2009..This may prove a risk factor for AMS by a mechanism that appears independent of impaired BBB function and cerebral oxidative metabolism...
- Commuting to high altitude: value of oxygen enrichment of room airJohn B West
Department of Medicine, University of California San Diego, La Jolla, CA, 92093 0623, USA
High Alt Med Biol 3:223-35. 2002..Oxygen enrichment of room air can play a major role in improving living and working conditions for commuters to high altitude...
- Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysisBengt Kayser
Institute of Movement Sciences and Sports Medicine, Medical Faculty, University of Geneva, Geneva, Switzerland
High Alt Med Biol 13:82-92. 2012..The degree of efficacy of acetazolamide for the prevention of AMS is limited when the baseline risk is low, and there is some evidence of dose-responsiveness...
- No evidence for interstitial lung oedema by extensive pulmonary function testing at 4,559 mC Dehnert
Internal Medicine VII, Sports Medicine, University Hospital Heidelberg, Heidelberg, Germany
Eur Respir J 35:812-20. 2010..Data obtained in mountaineers with early mild HAPE suggest that these methods may not be sensitive enough for the detection of interstitial pulmonary fluid accumulation...
- [High altitude headache: epidemiology, pathophysiology, therapy and prophylaxis]M Burtscher
Institut für Sportwissenschaften, Universitat Innsbruck, Osterreich
Wien Klin Wochenschr 111:830-6. 1999..The most beneficial effects however, may be achieved by the combined application of acetazolamide and aspirin. This combination increases oxygenation and reduces prostaglandin synthesis...
- CYBA and GSTP1 variants associate with oxidative stress under hypobaric hypoxia as observed in high-altitude pulmonary oedemaAastha Mishra
Institute of Genomics and Integrative Biology, Delhi, India
Clin Sci (Lond) 122:299-309. 2012..In conclusion, the risk alleles of CYBA and GSTP1, their haplotypes and gene-gene interactions are associated with imbalanced oxidative stress and, thereby, with high-altitude adaptation and mal-adaptation...
- Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humansBuddha Basnyat
Nepal International Clinic, Kathmandu, Nepal, Himalayan Rescue Association, Kathmandu, Nepal
High Alt Med Biol 9:209-16. 2008....
- Autonomic cardiovascular function in high-altitude Andean natives with chronic mountain sicknessC Keyl
Department of Anesthesiology, University Medical Center, 93042 Regensburg, Germany
J Appl Physiol (1985) 94:213-9. 2003..Temporary slow-frequency breathing may provide a beneficial effect on the autonomic cardiovascular function in high-altitude natives with CMS...
- Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group)Buddha Basnyat
Nepal International Clinic, Kathmandu, Nepal
Wilderness Environ Med 22:15-22. 2011..Hence, a prospective, double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy of spironolactone in the prevention of AMS...
- Index measured at an intermediate altitude to predict impending acute mountain sicknessPietro Amedeo Modesti
Department of Medical and Surgical Critical Care, University of Florence, Italy
Med Sci Sports Exerc 43:1811-8. 2011..The aim of the present study was to develop a predictive index, measured at an intermediate altitude, to predict the onset of AMS at a higher altitude...
- Prevention of acute mountain sickness by acetazolamide in Nepali porters: a double-blind controlled trialPeter Hillenbrand
Department of Medicine, Good Hope Hospital NHS Trust, Sutton Coldfield, West Midlands, UK
Wilderness Environ Med 17:87-93. 2006..This study aimed to determine the efficacy, tolerability, and practicality of acetazolamide for the prevention of acute mountain sickness (AMS) in Nepali trekking porters early in the trekking season...
- Acute mountain sickness, inflammation, and permeability: new insights from a blood biomarker studyColleen Glyde Julian
Altitude Research Center, Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, 12469 East 17 Place, Bldg 400, Aurora, CO 80045 0508, USA
J Appl Physiol (1985) 111:392-9. 2011..Conversely, AMS susceptibility does not appear to be related to an exaggerated inflammatory response...
- Acute mountain sickness score and hypoxemiaM M Hussain
High Altitude Medical Research Cell (HALMARC, Army Medical College, Rawalpindi
J Pak Med Assoc 51:173-9. 2001..CONCLUSION: The study concludes that severity of AMS is closely related to hypoxemia and combination therapy of acetazolamide-dexamethasone may be effective in preventing AMS...
- Ear, nose, and throat effects of high altitudeCemal Cingi
Department of Otorhinolaryngology, Osmangazi University, Eskisehir, Turkey
Eur Arch Otorhinolaryngol 267:467-71. 2010..These complaints can cause delays or cancelations in a person's climbing plans. In this article, we review the ear, nose, and throat effects of high altitude based on the relevant literature...
- Theophylline and acetazolamide reduce sleep-disordered breathing at high altitudeR Fischer
Dept of Medicine, Division of Pneumology, Medizinische Klinik Innenstadt, University of Munich, Munich, Germany
Eur Respir J 23:47-52. 2004..2 +/- 1.7% versus 81.0 +/- 3.0%). The authors conclude that both oral slow release theophylline and acetazolamide are effective to normalise high-altitude sleep-disordered breathing...
- Syndromes of subacute mountain sicknessInder S Anand
Heart Failure Program, VA Medical Center, and University of Minnesota Medical School, Minneapolis, 55417, USA
High Alt Med Biol 5:156-70. 2004..Thus, it appears that both these syndromes are human counterparts of brisket disease in cattle...
- The prevalence of and risk factors for acute mountain sickness in the Eastern and Western AlpsKlemens Mairer
Department of Sport Science, Medical Section, University of Innsbruck, Fürstenweg 185, Innsbruck, Austria
High Alt Med Biol 11:343-8. 2010..Thus, expert advice by mountain guides or experienced colleagues could help to reduce the AMS risk in these subjects...
- Ginkgo biloba for the prevention of severe acute mountain sickness (AMS) starting one day before rapid ascentJeffrey H Gertsch
The University of Hawaii, John A Burns School of Medicine, and the Kapiolani Clinical Research Center, Honolulu, Hawaii 96813, USA
High Alt Med Biol 3:29-37. 2002..Twenty-one of 26 (81%) subjects developed AMS overall. This is the first study to demonstrate that 1 day of pretreatment with ginkgo 60 mg TID may significantly reduce the severity of AMS prior to rapid ascent from sea level to 4205 m...
- International Training and Research in Environmental and Occupational HealthNELSON K STEENLAND; Fiscal Year: 2012..An additional specific problem in Peru and Chile is altitude sickness. In important percentage of the population in both these countries live in high altitude...
- ALTITUDE ADAPTATION IN CHRONIC LUNG DISEASEWilliam Graham; Fiscal Year: 1980..whether syndromes equivalent to those seen in normal subjects at much higher altitude, such as acute high altitude sickness, retinal hemorrhages or pulmonary edema occur in patients who have an equivalent oxygen tension at moderate ..
- Integrity of the Pulmonary Blood-Gas BarrierJohn West; Fiscal Year: 2007..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
- Human Biology Association 2002 Annual MeetingLORNA MOORE; Fiscal Year: 2002..abstract_text> ..
- Lung Perfusion Heterogeneity and Mechanisms of EdemaSusan R Hopkins; Fiscal Year: 2010..abstract_text> ..
- Altitude-induced hypoxia,IUGR and placental functionStacy Zamudio; Fiscal Year: 2006..Such work will aid substantially in elucidating the pathologies that involve placenta hypoxia, e.g., preeclampsia, diabetes and IUGR. ..
- Cardiovascular Chemoreflex-Baroreflex InteractionJOHN HALLIWILL; Fiscal Year: 2005..By addressing these aims, we will extend insights that are now only available in animals to a poorly understood area of cardiovascular regulation in humans. ..
- RESPIRATORY & AUTONOMIC PATHOPHYSIOLOGY--PANIC DISORDERWalton Roth; Fiscal Year: 2002..abstract_text> ..
- Nanosensor probes for oxygen imaging in vivoDavid Wilson; Fiscal Year: 2009..e. ready for larger scale synthesis and rigorous toxicology studies preparatory to use in clinical trials. ..
- MATURATION OF CEREBROVASCULAR RELAXANT MECHANISMSWilliam Pearce; Fiscal Year: 2009..This approach should also identify which cGMP-dependent mechanisms may be most amenable to therapeutic pharmacological manipulation in the critically ill neonate. ..
- DOPAMINE/GLUTAMATE AND HYPOXIC INJURY IN NEWBORN BRAINDavid Wilson; Fiscal Year: 2009..This understanding will be the basis for more effective treatment of patients who have been subjected to a period(s) of insufficient oxygen delivery to the brain. ..
- Physiological Consequences of Hypoxia and Lung DiseasePeter Wagner; Fiscal Year: 2008..abstract_text> ..
- Respiratory Therapeutic Procedures in Panic DisorderWalton Roth; Fiscal Year: 2006....
- Nitric Oxide/Carbon Monoxide in Pulmonary HypertentionRaed Dweik; Fiscal Year: 2006..The training component of this proposal will lead to the candidate's transition to a fully independent investigator. ..
- PERIPHERAL CHEMORECEPTORS: MECHANISMS & MODULATIONSSukhamay Lahiri; Fiscal Year: 2003..The aim of this proposal is to understand how the processes are initiated in the chemosensory cells. ..
- MATURATION OF CEREBROVASCULAR CONTRACTILE MECHANISMSWilliam Pearce; Fiscal Year: 2005..abstract_text> ..
- MBRS RISE Program at the University of Hawaii at HiloDaniel Brown; Fiscal Year: 2004..Goal #4 of faculty development in research will be met by creating a summer program for collaborative studies at research universities and by greater institutional support for intramural research grants. ..
- Neurite density in skin as a marker for neuropathic painAnne Louise Oaklander; Fiscal Year: 2005..abstract_text> ..
- Oxygen Carriers for Hypovolemic Circulatory CollapseRobert Winslow; Fiscal Year: 2007..The research described in this proposal will focus on molecules and formulations specifically tailored for use in prehospital and trauma settings. ..
- OXYGEN LEVELS AND RADIOSENSITIVITY IN TUMORSDavid Wilson; Fiscal Year: 2001..Phosphors will be selected which can be injected intravenously and then, after the oxygen measurements, are excreted by the kidney. ..
- CHRONIC HYPOXIA, UTERINE ARTERY VASOREGULATION & GROWTHLORNA MOORE; Fiscal Year: 2003..Aim #3 focuses on women residing at either low or high altitude in whom Doppler flow velocimetry and ultrasound imaging will be used to measure uterine artery blood flow. ..