altitude sickness

Summary

Summary: A morbid condition of ANOXIA caused by the reduced available oxygen at high altitudes.

Top Publications

  1. ncbi Acute mountain sickness: influence of susceptibility, preexposure, and ascent rate
    Michael Schneider
    Department of Internal Medicine, Division of Sports Medicine, University Hospital Heidelberg, Germany
    Med Sci Sports Exerc 34:1886-91. 2002
  2. ncbi Intraocular pressure during a very high altitude climb
    Martina M Bosch
    Department of Ophthalmology, University Hospital, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 51:1609-13. 2010
  3. pmc Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Proc Natl Acad Sci U S A 107:11459-64. 2010
  4. ncbi Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment
    Joshua O Stream
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Wilderness Environ Med 19:293-303. 2008
  5. ncbi Consensus statement on chronic and subacute high altitude diseases
    Fabiola Leon-Velarde
    Cayetano Heredia University IIA, Department of Biological and Physiological Sciences, Oxygen Transport Laboratory, Lima 100, Peru
    High Alt Med Biol 6:147-57. 2005
  6. ncbi Prevalence of acute mountain sickness in the Eastern Alps
    Klemens Mairer
    Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria
    High Alt Med Biol 10:239-45. 2009
  7. ncbi The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness
    Dante Penaloza
    Department of Medicine, Faculty of Medicine, University Cayetano Heredia, Lima, Peru
    Circulation 115:1132-46. 2007
  8. ncbi Autonomic control of the cardiovascular system during acclimatization to high altitude: effects of sildenafil
    Jérémy Cornolo
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, 93017 Bobigny, France
    J Appl Physiol 97:935-40. 2004
  9. ncbi Gene polymorphisms and high-altitude pulmonary edema susceptibility: a 2011 update
    Yongjun Luo
    Department of High Altitude Diseases, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, PR China
    Respiration 84:155-62. 2012
  10. ncbi Prevention and treatment of high-altitude pulmonary edema
    Marco Maggiorini
    Intensive Care Unit, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Prog Cardiovasc Dis 52:500-6. 2010

Detail Information

Publications275 found, 100 shown here

  1. ncbi Acute mountain sickness: influence of susceptibility, preexposure, and ascent rate
    Michael Schneider
    Department of Internal Medicine, Division of Sports Medicine, University Hospital Heidelberg, Germany
    Med Sci Sports Exerc 34:1886-91. 2002
    ..We examined the interaction of various established risk factors for acute mountain sickness (AMS) in a setting relevant for mountaineering and trekking...
  2. ncbi Intraocular pressure during a very high altitude climb
    Martina M Bosch
    Department of Ophthalmology, University Hospital, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 51:1609-13. 2010
    ..Reports on intraocular pressure (IOP) changes at high altitudes have provided inconsistent and even conflicting..
  3. pmc Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Proc Natl Acad Sci U S A 107:11459-64. 2010
    ..Whichever of these explanations is correct, the evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants...
  4. ncbi Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment
    Joshua O Stream
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Wilderness Environ Med 19:293-303. 2008
    ....
  5. ncbi Consensus statement on chronic and subacute high altitude diseases
    Fabiola Leon-Velarde
    Cayetano Heredia University IIA, Department of Biological and Physiological Sciences, Oxygen Transport Laboratory, Lima 100, Peru
    High Alt Med Biol 6:147-57. 2005
    ..Most of the cases of high altitude diseases are preventable if on-site personnel identify the condition and implement appropriate care...
  6. ncbi Prevalence of acute mountain sickness in the Eastern Alps
    Klemens Mairer
    Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria
    High Alt Med Biol 10:239-45. 2009
    ..Consideration of easily modifiable risk factors such as individual exertion and water intake could markedly reduce AMS and contribute to the enjoyment of mountaineering...
  7. ncbi The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness
    Dante Penaloza
    Department of Medicine, Faculty of Medicine, University Cayetano Heredia, Lima, Peru
    Circulation 115:1132-46. 2007
    ..Chronic mountain sickness is a public health problem in the Andean mountains and other mountainous regions around the world. Therefore, dissemination of preventive and therapeutic measures is essential...
  8. ncbi Autonomic control of the cardiovascular system during acclimatization to high altitude: effects of sildenafil
    Jérémy Cornolo
    Laboratoire Réponses Cellulaires et Fonctionnelles à l Hypoxie, Universite Paris 13, 93017 Bobigny, France
    J Appl Physiol 97:935-40. 2004
    ..Sil had no deleterious effects on the cardiovascular response to high-altitude exposure and its control by the autonomic nervous system...
  9. ncbi Gene polymorphisms and high-altitude pulmonary edema susceptibility: a 2011 update
    Yongjun Luo
    Department of High Altitude Diseases, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, PR China
    Respiration 84:155-62. 2012
    ..The goal of this review article is to summarize the current literature and to define the outstanding areas of research that need to be explored to advance our ability to predict when HAPE will occur...
  10. ncbi Prevention and treatment of high-altitude pulmonary edema
    Marco Maggiorini
    Intensive Care Unit, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Prog Cardiovasc Dis 52:500-6. 2010
    ..If progressive high altitude acclimatization would not be possible, prophylaxis with nifedipine or tadalafil for long sojourns at high altitude or dexamethasone for a short stay of less then 5 days should be recommended...
  11. ncbi Role of hypobaria in fluid balance response to hypoxia
    Jack A Loeppky
    Cardiology Section, VA Medical Center, Albuquerque, New Mexico
    High Alt Med Biol 6:60-71. 2005
    ..The fluid retention at ALT in AMS-susceptible subjects appears related to a synergistic interaction involving reduced P(B) and ADH and ALDO...
  12. ncbi Appetite at "high altitude" [Operation Everest III (Comex-'97)]: a simulated ascent of Mount Everest
    M S Westerterp-Plantenga
    Maastricht University, Maastricht, The Netherlands
    J Appl Physiol (1985) 87:391-9. 1999
    ..We conclude that exposure to hypobaric hypoxia per se appears to be associated with a change in the attitude toward eating and with a decreased appetite and food intake...
  13. ncbi Oximetry, heart rate variability, and the diagnosis of mild-to-moderate acute mountain sickness
    Michael S Koehle
    School of Human Kinetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Eur J Emerg Med 17:119-22. 2010
    ..In conclusion, in patients with SpO2 of 86% or more at 4380 m or higher, the likelihood of AMS is low. Diastolic blood pressure correlated with AMS severity, whereas heart rate variability was not useful in the diagnosis of AMS...
  14. ncbi Who are more at risk for acute mountain sickness: a prospective study in Qinghai-Tibet railroad construction workers on Mt. Tanggula
    Tian Yi Wu
    Physiological Research Group of the Ministry of Railway, High Altitude Medical Research Institute, Xining, Qinghai 810012, China
    Chin Med J (Engl) 125:1393-400. 2012
    ..Tanggula during the construction of the Qinghai-Tibet railroad. This study explored the risk factors predisposing workers to developing AMS and attempted to develop more effective ways of preventing and treating AMS...
  15. ncbi High altitude sleep disturbances monitored by actigraphy and polysomnography
    Yvonne Nussbaumer-Ochsner
    Pulmonary Division and Sleep Disorders Center, University Hospital of Zurich, and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    High Alt Med Biol 12:229-36. 2011
    ..Data on sleep at altitude are scant due to the limited availability of polysomnography. Therefore, we investigated whether actigraphy might serve as a simple tool for monitoring sleep during altitude field studies...
  16. ncbi High altitude headache. A prospective study of its clinical characteristics
    M Serrano-Dueñas
    Movement Disorders Clinic, Neurological Service, Hospital Carlos Andrade Marín and, Medicine Faculty, Pontificia Universidad Catolica del Ecuador, Quito, Ecuador
    Cephalalgia 25:1110-6. 2005
    ..8%; concurrent symptoms referred to, anorexia 26.8%, irritability 26.5%, and finally pessimism and anxiety feelings 33.2 and 29.5%, respectively. We believe that elements provided by us must lead to a new official AH diagnosis criterion...
  17. ncbi Acute mountain sickness in Iranian trekkers around Mount Damavand (5671 m) in Iran
    Vahid Ziaee
    Department of Pediatrics, Sport Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Wilderness Environ Med 14:214-9. 2003
    ..Many trekkers up Mount Damavand run the risk of developing acute mountain sickness (AMS); however, not much is documented concerning the incidence of AMS and its related factors within this population...
  18. ncbi Physiology and pathophysiology with ascent to altitude
    Biff F Palmer
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Med Sci 340:69-77. 2010
    ..The most common clinical manifestations of altitude illness are acute mountain sickness, high altitude pulmonary edema, and high altitude cerebral edema...
  19. ncbi The cerebral effects of ascent to high altitudes
    Mark H Wilson
    Centre for Altitude, Space and Extreme Environment Medicine, University College London, London, UK
    Lancet Neurol 8:175-91. 2009
    ..The effects of hypobaric hypoxia might also provide new insights into the understanding of hypoxia in the clinical setting...
  20. ncbi Cerebrovascular responses to altitude
    Julien V Brugniaux
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Respir Physiol Neurobiol 158:212-23. 2007
    ..Existing gaps in our knowledge of CBF and altitude, and areas of future investigation include effects of longer exposures, intermittent hypoxia, and gender differences in the CBF responses to altitude...
  21. ncbi Physiological aspects of high-altitude pulmonary edema
    Peter Bartsch
    Department of Internal Medicine VII, Division of Sports Medicine, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    J Appl Physiol (1985) 98:1101-10. 2005
    ..The combination of high flow at higher pressure results in pressures, which exceed the structural and dynamic capacity of the alveolar capillary barrier to maintain normal alveolar fluid balance...
  22. ncbi Pathogenesis of high-altitude pulmonary edema: inflammation is not an etiologic factor
    Erik R Swenson
    Pulmonary and Critical Care Section, S 111 Pulm, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    JAMA 287:2228-35. 2002
    ....
  23. ncbi High-altitude illness
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal Himalayan Rescue Association, Kathmandu, Nepal
    Lancet 361:1967-74. 2003
    ..Despite investigation of other agents, acetazolamide remains the preferred drug for preventing AMS. The next few years are likely to see many advances in the understanding of the causes and management of high-altitude illness...
  24. ncbi General introduction to altitude adaptation and mountain sickness
    P Bartsch
    Department of Internal Medicine, Division of Sports Medicine, Medical University Clinic, Heidelberg, Germany heidelberg de
    Scand J Med Sci Sports 18:1-10. 2008
    ..A new classification of altitude levels based on the effects on performance and well-being is proposed and an overview given over the various modalities using hypoxia and altitude for improvement of performance...
  25. ncbi Reduced oxygen due to high-altitude exposure relates to atrophy in motor-function brain areas
    M Di Paola
    Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy
    Eur J Neurol 15:1050-7. 2008
    ..The present study was designed to explore the effects of high-altitude exposure using a quantitative MRI technique, voxel-based morphometry...
  26. ncbi High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein
    G Hartmann
    Ludwig Maximilians University, Munich, Germany
    Cytokine 12:246-52. 2000
    ..The existence and the kinetics of high altitude-induced cytokines found in this study support the hypothesis that inflammation is involved in the development of HAPO...
  27. ncbi New insights in the pathogenesis of high-altitude pulmonary edema
    Urs Scherrer
    Department of Internal Medicine and the Botnar Center for Extreme Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Prog Cardiovasc Dis 52:485-92. 2010
    ....
  28. ncbi Human genetic adaptation to high altitude
    L G Moore
    Department of Anthropology, University of Colorado at Denver, Denver CO 80217, USA
    High Alt Med Biol 2:257-79. 2001
    ....
  29. ncbi High altitude pulmonary edema: a pressure-induced leak
    Christoph Dehnert
    Medical University Clinic, Department of Internal Medicine, Div of Sports Medicine, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Respir Physiol Neurobiol 158:266-73. 2007
    ..Lower levels of exhaled NO in hypoxia before and during HAPE suggest that this abnormality also occurs in the lungs and polymorphisms of the eNOS gene are associated with susceptibility to HAPE in the Indian and Japanese population...
  30. ncbi Normo or hypobaric hypoxic tests: propositions for the determination of the individual susceptibility to altitude illnesses
    Gustave Savourey
    Département des Facteurs Humains, Pôle tolérance climatique et vêtement, Centre de Recherches du Service de Sante des Armees, BP 87 38702, La Tronche Cedex, France
    Eur J Appl Physiol 100:193-205. 2007
    ..47 + 0.104PetO2(hPa)-0.68CpO2 (%), (R = 0.77, P = 0.001); and AMSmean = 3.91 + 0.059Deltaf + 0.438HCR-0.135CpO2 (R = 0.71, P = 0.017)...
  31. pmc Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns
    Guoqiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2342. 2008
    ....
  32. ncbi Changes of hematocrit and hemoglobin concentration in the cold Himalayan environment in dependence on total body fluid
    Markus Tannheimer
    Department of Visceral and Thoracic Surgery, Armed Forces Hospital Ulm, Ulm, Germany
    Sleep Breath 14:193-9. 2010
    ..Therefore, the influence of water distribution on hemoglobin (Hb) and hematocrit (Hct) values during a long-term exposure at high altitude was investigated...
  33. ncbi KGF-2 targets alveolar epithelia and capillary endothelia to reduce high altitude pulmonary oedema in rats
    Jun She
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
    J Cell Mol Med 16:3074-84. 2012
    ..Thus, KGF-2 may represent a potential drug candidate for the prevention of HAPE...
  34. pmc Susceptibility to high altitude pulmonary oedema: role of ACE and ET-1 polymorphisms
    R Charu
    Thorax 61:1011-2. 2006
  35. ncbi Risk factors for high-altitude headache in mountaineers
    Martin Burtscher
    Department of Sport Science, University of Innsbruck, Innsbruck, Austria
    Cephalalgia 31:706-11. 2011
    ..The aim was to identify most relevant risk factors of high-altitude headache within a broad mountaineering population through a prospective, observational, rater-blinded study...
  36. pmc The role of oxygen-increased respirator in humans ascending to high altitude
    Guanghao Shen
    Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi, 710049, PR China
    Biomed Eng Online 11:49. 2012
    ..Many instruments have been developed to treat mild cases of AMS. However, long-lasting and portable anti-hypoxia equipment for individual is not yet available...
  37. ncbi Blood pressure responses in young adults first exposed to high altitude for 12 months at 3550 m
    Patricia Siques
    Institute of Health Studies, Universidad Arturo Prat, Iquique, Chile
    High Alt Med Biol 10:329-35. 2009
    ..Further, a sustained high DBP should be a matter of epidemiological concern and emphasizes the need for BP monitoring among young lowlanders exposed to high altitude...
  38. ncbi The body weight loss during acute exposure to high-altitude hypoxia in sea level residents
    Ri Li Ge
    Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China
    Sheng Li Xue Bao 62:541-6. 2010
    ....
  39. ncbi Reduced autonomic activity during stepwise exposure to high altitude
    K Sevre
    Department of Cardiology, , Oslo, Norway
    Acta Physiol Scand 173:409-17. 2001
    ..1 +/- 6%, P = 0.03). Diastolic blood pressure, HR and adrenaline displayed similar tendencies. We conclude that a transient reduction in parasympathetic and sympathetic activity was demonstrated during stepwise exposure to high altitude...
  40. ncbi Alterations in autonomic nervous control of heart rate among tourists at 2700 and 3700 m above sea level
    M Kanai
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi, Japan
    Wilderness Environ Med 12:8-12. 2001
    ..The sympathetic nervous system was dominant to the parasympathetic at 3700 m. These alterations in the autonomic nervous system might play some role in physical fitness at high altitudes...
  41. ncbi Epidemiology of acute mountain sickness on Jade Mountain, Taiwan: an annual prospective observational study
    Shih Hao Wang
    Department of Emergency Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
    High Alt Med Biol 11:43-9. 2010
    ..The overall presentation of AMS was similar to that on other major world mountains...
  42. ncbi Everest or bust: a cross sectional, epidemiological study of acute mountain sickness at 4243 meters in the Himalayas
    B Basnyat
    Himalayan Rescue Association Nepal International Clinic Patan Hospital, Nepal
    Aviat Space Environ Med 70:867-73. 1999
    ....
  43. ncbi Endothelin-1 gene variants and levels associate with adaptation to hypobaric hypoxia in high-altitude natives
    Charu Rajput
    Institute of Genomics and Integrative Biology, Delhi 110 007, India Centre for Biotechnology, Hamdard University, New Delhi 110 062, India
    Biochem Biophys Res Commun 341:1218-24. 2006
    ..Interaction between these alleles and association with lower ET-1 levels strengthen their association with high-altitude adaptation. Presence of such alleles in sojourners may help in acclimatization...
  44. ncbi Pathophysiological significance of peroxidative stress, neuronal damage, and membrane permeability in acute mountain sickness
    Damian M Bailey
    Department of Physiology, University of Glamorgan, Pontypridd, South Wales, UK
    J Appl Physiol (1985) 96:1459-63. 2004
    ..The pathophysiological significance of increased sarcolemmal membrane permeability and inflammatory response, either as a cause or epiphenomenon of AMS and/or high-altitude pulmonary edema, remains to be elucidated...
  45. ncbi Pulmonary extravascular fluid accumulation in recreational climbers: a prospective study
    George Cremona
    Unit of Respiratory Medicine, San Raffaele University Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
    Lancet 359:303-9. 2002
    ..High altitude pulmonary oedema (HAPE) that is severe enough to require urgent medical care is infrequent. We hypothesised that subclinical HAPE is far more frequent than suspected during even modest climbs of average effort...
  46. ncbi Oxidative stress and erythropoietin response in altitude exposure
    Hsien Hao Huang
    Department of Emergency Medicine, Taipei VeteransGeneral Hospital, College of Medicine, NationalYang Ming University, Taipei, Taiwan
    Clin Invest Med 31:E380-5. 2008
    ..We hypothesized that the altitude-oxidative stress and EPO response would be associated with the presence or absence of acute mountain sickness (AMS) in subjects exposed at high altitude...
  47. ncbi Sleep architecture changes during a trek from 1400 to 5000 m in the Nepal Himalaya
    Pamela L Johnson
    David Read Laboratory, Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    J Sleep Res 19:148-56. 2010
    ..Periodic breathing was commonplace at all altitudes, and while associated with increases in arousal indices, did not have any apparent effect on sleep architecture...
  48. pmc Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHAIT)
    Jeffrey H Gertsch
    Department of Internal Medicine, Maricopa Medical Center, 2601 E Roosevelt Avenue number O D 10, Phoenix, AZ 85008, USA
    BMJ 328:797. 2004
    ..To evaluate the efficacy of ginkgo biloba, acetazolamide, and their combination as prophylaxis against acute mountain sickness...
  49. ncbi Genetic contribution of the endothelial nitric oxide synthase gene to high altitude adaptation in sherpas
    Yunden Droma
    Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    High Alt Med Biol 7:209-20. 2006
    ..The nitric oxide metabolites (NO( x )) in serum vary individually, thus it is not a reliable indicator for endogenous nitric oxide production...
  50. ncbi The physiologic basis of high-altitude diseases
    John B West
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Ann Intern Med 141:789-800. 2004
  51. ncbi New insights into ocular blood flow at very high altitudes
    Martina M Bosch
    Department of Opthamology, University Hospital, Zurich, Switzerland
    J Appl Physiol (1985) 106:454-60. 2009
    ..We demonstrate that sojourns at high altitudes trigger distinct behavior of retinal and choroidal blood flow. Increase in retinal but not in choroidal blood flow correlated with the occurrence of AMS-related symptoms...
  52. pmc Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia
    Jim Hansen
    Copenhagen Muscle Research Centre, Rigshospitalet, Copenhagen, Denmark
    J Physiol 546:921-9. 2003
    ..Surprisingly, chemoreflex activation by hypoxia and baroreflex deactivation by dehydration together could account for only a small part of this response, leaving the major underlying mechanisms unexplained...
  53. ncbi Frontiers of hypoxia research: acute mountain sickness
    R C Roach
    New Mexico Resonance, Box 343, Montezuma, NM 87731, USA
    J Exp Biol 204:3161-70. 2001
    ..We believe that an examination of the responses of the central nervous system to acute hypoxia will reveal important new pathophysiological processes that may help explain AMS and HACE...
  54. ncbi Sleep at high altitude
    John V Weil
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, 4200 East NinthAvenue, Denver 80262, USA
    High Alt Med Biol 5:180-9. 2004
    ..Interventions that improve sleep quality at high altitude include acetazolamide and benzodiazepines...
  55. pmc Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function
    D M Bailey
    Neurovascular Research Laboratory, Faculty of Health, Science and Sport, University of Glamorgan, Mid Glamorgan, South Wales CF37 1DL, UK
    J Physiol 587:73-85. 2009
    ..In conclusion, these findings suggest that AMS is associated with altered redox homeostasis and disordered CA independent of barrier disruption...
  56. ncbi Effects of high altitude exposure on cerebral hemodynamics in normal subjects
    Aurélie van Osta
    Laboratory of Physiology, Faculty of Medicine, Free University of Brussels, Belgium
    Stroke 36:557-60. 2005
    ..If so, AMS could result from an alteration of dynamic autoregulation of cerebral blood flow resulting in overperfusion of capillaries and vasogenic cerebral edema...
  57. ncbi Alternations of heart rate variability at lower altitude in the predication of trekkers with acute mountain sickness at high altitude
    Hsien Hao Huang
    Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R O C
    Clin J Sport Med 20:58-63. 2010
    ..To determine the change and relationship of spectral components of heart rate variability (HRV) measurements in subjects with or without acute mountain sickness (AMS) at both low and high altitude...
  58. ncbi Chronic mountain sickness on the Qinghai-Tibetan plateau
    Tian Yi Wu
    High Altitude Medical Research Institute, Xining 810012, China
    Chin Med J (Engl) 118:161-8. 2005
  59. ncbi Effect of hypohydration and altitude exposure on aerobic exercise performance and acute mountain sickness
    John W Castellani
    Thermal and Mountain Medicine Division, U S Army Research Institute of Environmental Medicine, 42 Kansas St, Natick, MA 01760 5007, USA
    J Appl Physiol (1985) 109:1792-800. 2010
    ..07). In conclusion, hypohydration at 3,048 m 1) degrades aerobic performance in an additive manner with that induced by ALT; and 2) did not appear to increase the prevalence/severity of AMS symptoms...
  60. ncbi Awareness, prevalence, medication use, and risk factors of acute mountain sickness in tourists trekking around the Annapurnas in Nepal: a 12-year follow-up
    Samuel Gaillard
    Département de médecine communautaire, Hopitaux Universitaires, Geneva, Switzerland
    High Alt Med Biol 5:410-9. 2004
    ..In conclusion, in 1998 as compared to 1986, trekkers were older, climbed more slowly, had better awareness of altitude illness, used more medication, and suffered less from AMS...
  61. ncbi Who should not go high: chronic disease and work at altitude during construction of the Qinghai-Tibet railroad
    Tian Yi Wu
    Physiological Research Group of the Ministry of Railroad, P R China
    High Alt Med Biol 8:88-107. 2007
    ....
  62. pmc Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological
    Damian Miles Bailey
    Neurovascular Research Laboratory, Faculty of Health, Science and Sport, University of Glamorgan, Pontypridd, CF37 1DL, South Wales, UK
    Cell Mol Life Sci 66:3583-94. 2009
    ..This has led to a re-evaluation of the relevant pathogenic events with a specific focus on free radicals and their interaction with the trigeminovascular system...
  63. ncbi Hypoxic ventilatory response, ventilation, gas exchange, and fluid balance in acute mountain sickness
    Peter Bartsch
    Department of Internal Medicine, Division of Sports Medicine, Medical University Clinic, Heidelberg, Germany
    High Alt Med Biol 3:361-76. 2002
    ....
  64. ncbi Body temperature, autonomic responses, and acute mountain sickness
    Jack A Loeppky
    Cardiology Section 111B, VA Medical Center, Albuquerque, NM, USA
    High Alt Med Biol 4:367-73. 2003
    ..Greater hypoxic vasodilation and elevated HR in AMS in the absence of other changes suggest that augmentation of beta-adrenergic tone may be involved in early AMS pathophysiology...
  65. ncbi Effects of hypobaric hypoxia on cerebral autoregulation
    Andrew W Subudhi
    Altitude Research Center, University of Colorado at Denver, School of Medicine, Denver, CO, USA
    Stroke 41:641-6. 2010
    ..This investigation evaluated relationship between CA and AMS over 9 hours of hypobaric hypoxia...
  66. ncbi Efficacy of low-dose acetazolamide (125 mg BID) for the prophylaxis of acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial
    Buddha Basnyat
    Nepal International Clinic, Himalayan Rescue Association
    High Alt Med Biol 4:45-52. 2003
    ..We concluded that acetazolamide 125 mg twice daily was effective in decreasing the incidence of AMS in this Himalayan trekking population...
  67. ncbi Work at high altitude and oxidative stress: antioxidant nutrients
    E W Askew
    Division of Foods and Nutrition, University of Utah, 250 South 1850 East Room 239 N HPR, Salt Lake City, UT 84112, USA
    Toxicology 180:107-19. 2002
    ..antioxidant supplementation is when does oxidative stress become potentially damaging enough to merit antioxidant therapy and conversely, what degree of oxidative stress is necessary to foster the adaptive response of altitude exposure?..
  68. ncbi Optic nerve sheath diameter correlates with the presence and severity of acute mountain sickness: evidence for increased intracranial pressure
    Peter J Fagenholz
    Himalayan Rescue Association, Pheriche Clinic, Spring Season 2006, Nepal
    J Appl Physiol (1985) 106:1207-11. 2009
    ..84, P < 0.001). Optic nerve sheath diameter, a proxy for intracranial pressure, is associated with the presence and severity of AMS...
  69. ncbi Going high with preexisting neurological conditions
    Ralf W Baumgartner
    Department of Neurology, University Hospital Zurich, Switzerland
    High Alt Med Biol 8:108-16. 2007
    ..These recommendations are not based on the results of controlled randomized trials, but mainly on case reports, pathophysiological considerations, and extrapolations from the low altitude situation...
  70. ncbi Acute normobaric hypoxia stimulates erythropoietin release
    Richard W A Mackenzie
    Chelsea School Research Center, University of Brighton, Eastbourne, United Kingdom
    High Alt Med Biol 9:28-37. 2008
    ..1 mU/mL (9.8%). It was concluded that an acute bout of hypoxia, has the capacity to elevate plasma EPO. This study also demonstrates that the increase in EPO accumulation was 2 times greater than the calculated measurement of error...
  71. ncbi Gene expression, autonomic function and chronic hypoxia:lessons from the Andes
    Otto Appenzeller
    New Mexico Health Enhancement and Marathon Clinics Research Foundation, Albuquerque, NM 87122 1424, USA
    Clin Auton Res 16:217-22. 2006
    ..These changes may support the physiologic alterations induced by the ambient hypoxia at altitude and impact organism survival. They also suggest therapeutic strategies for autonomic and neurodegenerative diseases at sea level...
  72. ncbi Obesity: associations with acute mountain sickness
    Ge Ri-Li
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA
    Ann Intern Med 139:253-7. 2003
    ..Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been studied prospectively...
  73. ncbi Platelet count and function at high altitude and in high-altitude pulmonary edema
    T Lehmann
    Dept of Internal Medicine, Kantonsspital, CH 7000 Chur, Switzerland
    J Appl Physiol 100:690-4. 2006
    ..These effects are, however, not more pronounced in individuals with a history of HAPE or actually suffering from HAPE than in controls and therefore may not be a pathophysiological mechanism of HAPE...
  74. ncbi Recompression therapy of mountain sickness
    Dubravko Marković
    General Hospital Pula, Pula, Croatia
    Arh Hig Rada Toksikol 53:3-6. 2002
    ..Portable hyperbaric chamber is recommended for the treatment of severe cases of acute mountain sickness, as well as for risky descent to lower altitudes...
  75. ncbi Ginkgo biloba and acetazolamide prophylaxis for acute mountain sickness: a randomized, placebo-controlled trial
    Tony Chow
    Department of Emergency Medicine, Loma Linda University Medical Center and Children s Hospital, Loma Linda, CA 92354, USA
    Arch Intern Med 165:296-301. 2005
    ..We performed a randomized, placebo-controlled trial of acetazolamide vs Ginkgo biloba for AMS prophylaxis...
  76. ncbi Lack of evidence for association of high altitude pulmonary edema and polymorphisms of the NO pathway
    Johanna Weiss
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Bergheimer Strasse 58, D 69115 Heidelberg, Germany
    High Alt Med Biol 4:355-66. 2003
    ..The results of this study suggest that none of these genetic variants plays a substantial role in the pathogenesis of HAPE in Caucasians, but does not exclude epistatic effects that might still involve the genetic systems studied here...
  77. ncbi The Qinghai-Tibetan plateau: how high do Tibetans live?
    T Wu
    Department of Physiology and Mountain Sickness, High Altitude Medical Research Institute, Xining, Qinghai, P R China
    High Alt Med Biol 2:489-99. 2001
    ..Thus the apparently low incidence of CMS in Tibetans cannot be ascribed to "geographic differences." We propose that the genetic adaptation to hypoxia that has occurred in Tibetans is of importance in CMS...
  78. ncbi High-altitude headache
    Marcos Serrano-Dueñas
    Carlos Andrade Marin Hospital, Movement Disorders Unit, Neurological Service, Quito, Ecuador
    Expert Rev Neurother 7:245-8. 2007
    ..These are neurogenic problems secondary to hypoxia caused by hypobarism and, in all events, have a common denominator: hypoxia and a fundamental white organ, the brain...
  79. ncbi Angiotensin converting enzyme insertion allele in relation to high altitude adaptation
    M A Qadar Pasha
    Functional Genomics Unit, Centre for Biochemical Technology, Delhi, India
    Ann Hum Genet 65:531-6. 2001
    ..The I allele frequency was 0.72 in the MLLs, 0.67 in the HLs and 0.55 in the LLs. Polymorphism study suggested that the II genotype could be associated with altitude adaptation, which might influence physical efficiency...
  80. ncbi High-altitude retinopathy and optical coherence tomography findings
    Rajeev K Seth
    Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA
    Semin Ophthalmol 25:13-5. 2010
    ..To report the case and OCT findings of a case of high altitude retinopathy (HAR)...
  81. ncbi Do changes in lung function predict high-altitude pulmonary edema at an early stage?
    Oliver Senn
    Pulmonary Division, University Hospital of Zurich and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Med Sci Sports Exerc 38:1565-70. 2006
    ..Therefore, we investigated the time course of pulmonary function in relation to hemodynamics and clinical symptoms in mountaineers ascending rapidly to high altitude...
  82. ncbi Pharmacologic prophylaxis for acute mountain sickness: a systematic shortcut review
    Rawle A Seupaul
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Ann Emerg Med 59:307-317.e1. 2012
    ..Since 2000, a number of other agents have been reported to be beneficial. This EBEM review evaluates the most current evidence on this topic...
  83. ncbi Migraines and high-altitude headaches
    Jacky A Miller
    Wilderness Environ Med 14:286-7. 2003
  84. ncbi Increased cerebral output of free radicals during hypoxia: implications for acute mountain sickness?
    Damian M Bailey
    Neurovascular Research Laboratory, Faculty of Health, Science and Sport, University of Glamorgan, Mid Glamorgan, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 297:R1283-92. 2009
    ..This may prove a risk factor for AMS by a mechanism that appears independent of impaired BBB function and cerebral oxidative metabolism...
  85. ncbi Commuting to high altitude: value of oxygen enrichment of room air
    John B West
    Department of Medicine, University of California San Diego, La Jolla, CA, 92093 0623, USA
    High Alt Med Biol 3:223-35. 2002
    ..Oxygen enrichment of room air can play a major role in improving living and working conditions for commuters to high altitude...
  86. ncbi Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysis
    Bengt Kayser
    Institute of Movement Sciences and Sports Medicine, Medical Faculty, University of Geneva, Geneva, Switzerland
    High Alt Med Biol 13:82-92. 2012
    ..The degree of efficacy of acetazolamide for the prevention of AMS is limited when the baseline risk is low, and there is some evidence of dose-responsiveness...
  87. ncbi No evidence for interstitial lung oedema by extensive pulmonary function testing at 4,559 m
    C Dehnert
    Internal Medicine VII, Sports Medicine, University Hospital Heidelberg, Heidelberg, Germany
    Eur Respir J 35:812-20. 2010
    ..Data obtained in mountaineers with early mild HAPE suggest that these methods may not be sensitive enough for the detection of interstitial pulmonary fluid accumulation...
  88. ncbi [High altitude headache: epidemiology, pathophysiology, therapy and prophylaxis]
    M Burtscher
    Institut für Sportwissenschaften, Universitat Innsbruck, Osterreich
    Wien Klin Wochenschr 111:830-6. 1999
    ..The most beneficial effects however, may be achieved by the combined application of acetazolamide and aspirin. This combination increases oxygenation and reduces prostaglandin synthesis...
  89. ncbi CYBA and GSTP1 variants associate with oxidative stress under hypobaric hypoxia as observed in high-altitude pulmonary oedema
    Aastha Mishra
    Institute of Genomics and Integrative Biology, Delhi, India
    Clin Sci (Lond) 122:299-309. 2012
    ..In conclusion, the risk alleles of CYBA and GSTP1, their haplotypes and gene-gene interactions are associated with imbalanced oxidative stress and, thereby, with high-altitude adaptation and mal-adaptation...
  90. ncbi Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal, Himalayan Rescue Association, Kathmandu, Nepal
    High Alt Med Biol 9:209-16. 2008
    ....
  91. ncbi Autonomic cardiovascular function in high-altitude Andean natives with chronic mountain sickness
    C Keyl
    Department of Anesthesiology, University Medical Center, 93042 Regensburg, Germany
    J Appl Physiol (1985) 94:213-9. 2003
    ..Temporary slow-frequency breathing may provide a beneficial effect on the autonomic cardiovascular function in high-altitude natives with CMS...
  92. ncbi Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group)
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal
    Wilderness Environ Med 22:15-22. 2011
    ..Hence, a prospective, double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy of spironolactone in the prevention of AMS...
  93. ncbi Index measured at an intermediate altitude to predict impending acute mountain sickness
    Pietro Amedeo Modesti
    Department of Medical and Surgical Critical Care, University of Florence, Italy
    Med Sci Sports Exerc 43:1811-8. 2011
    ..The aim of the present study was to develop a predictive index, measured at an intermediate altitude, to predict the onset of AMS at a higher altitude...
  94. ncbi Prevention of acute mountain sickness by acetazolamide in Nepali porters: a double-blind controlled trial
    Peter Hillenbrand
    Department of Medicine, Good Hope Hospital NHS Trust, Sutton Coldfield, West Midlands, UK
    Wilderness Environ Med 17:87-93. 2006
    ..This study aimed to determine the efficacy, tolerability, and practicality of acetazolamide for the prevention of acute mountain sickness (AMS) in Nepali trekking porters early in the trekking season...
  95. pmc Acute mountain sickness, inflammation, and permeability: new insights from a blood biomarker study
    Colleen Glyde Julian
    Altitude Research Center, Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, 12469 East 17 Place, Bldg 400, Aurora, CO 80045 0508, USA
    J Appl Physiol (1985) 111:392-9. 2011
    ..Conversely, AMS susceptibility does not appear to be related to an exaggerated inflammatory response...
  96. ncbi Acute mountain sickness score and hypoxemia
    M M Hussain
    High Altitude Medical Research Cell (HALMARC, Army Medical College, Rawalpindi
    J Pak Med Assoc 51:173-9. 2001
    ..CONCLUSION: The study concludes that severity of AMS is closely related to hypoxemia and combination therapy of acetazolamide-dexamethasone may be effective in preventing AMS...
  97. ncbi Ear, nose, and throat effects of high altitude
    Cemal Cingi
    Department of Otorhinolaryngology, Osmangazi University, Eskisehir, Turkey
    Eur Arch Otorhinolaryngol 267:467-71. 2010
    ..These complaints can cause delays or cancelations in a person's climbing plans. In this article, we review the ear, nose, and throat effects of high altitude based on the relevant literature...
  98. ncbi Theophylline and acetazolamide reduce sleep-disordered breathing at high altitude
    R Fischer
    Dept of Medicine, Division of Pneumology, Medizinische Klinik Innenstadt, University of Munich, Munich, Germany
    Eur Respir J 23:47-52. 2004
    ..2 +/- 1.7% versus 81.0 +/- 3.0%). The authors conclude that both oral slow release theophylline and acetazolamide are effective to normalise high-altitude sleep-disordered breathing...
  99. ncbi Syndromes of subacute mountain sickness
    Inder S Anand
    Heart Failure Program, VA Medical Center, and University of Minnesota Medical School, Minneapolis, 55417, USA
    High Alt Med Biol 5:156-70. 2004
    ..Thus, it appears that both these syndromes are human counterparts of brisket disease in cattle...
  100. ncbi The prevalence of and risk factors for acute mountain sickness in the Eastern and Western Alps
    Klemens Mairer
    Department of Sport Science, Medical Section, University of Innsbruck, Fürstenweg 185, Innsbruck, Austria
    High Alt Med Biol 11:343-8. 2010
    ..Thus, expert advice by mountain guides or experienced colleagues could help to reduce the AMS risk in these subjects...
  101. ncbi Ginkgo biloba for the prevention of severe acute mountain sickness (AMS) starting one day before rapid ascent
    Jeffrey H Gertsch
    The University of Hawaii, John A Burns School of Medicine, and the Kapiolani Clinical Research Center, Honolulu, Hawaii 96813, USA
    High Alt Med Biol 3:29-37. 2002
    ..Twenty-one of 26 (81%) subjects developed AMS overall. This is the first study to demonstrate that 1 day of pretreatment with ginkgo 60 mg TID may significantly reduce the severity of AMS prior to rapid ascent from sea level to 4205 m...

Research Grants24

  1. International Training and Research in Environmental and Occupational Health
    NELSON K STEENLAND; Fiscal Year: 2012
    ..An additional specific problem in Peru and Chile is altitude sickness. In important percentage of the population in both these countries live in high altitude...
  2. ALTITUDE ADAPTATION IN CHRONIC LUNG DISEASE
    William Graham; Fiscal Year: 1980
    ..whether syndromes equivalent to those seen in normal subjects at much higher altitude, such as acute high altitude sickness, retinal hemorrhages or pulmonary edema occur in patients who have an equivalent oxygen tension at moderate ..
  3. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  4. Human Biology Association 2002 Annual Meeting
    LORNA MOORE; Fiscal Year: 2002
    ..abstract_text> ..
  5. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..abstract_text> ..
  6. Altitude-induced hypoxia,IUGR and placental function
    Stacy Zamudio; Fiscal Year: 2006
    ..Such work will aid substantially in elucidating the pathologies that involve placenta hypoxia, e.g., preeclampsia, diabetes and IUGR. ..
  7. Cardiovascular Chemoreflex-Baroreflex Interaction
    JOHN HALLIWILL; Fiscal Year: 2005
    ..By addressing these aims, we will extend insights that are now only available in animals to a poorly understood area of cardiovascular regulation in humans. ..
  8. RESPIRATORY & AUTONOMIC PATHOPHYSIOLOGY--PANIC DISORDER
    Walton Roth; Fiscal Year: 2002
    ..abstract_text> ..
  9. Nanosensor probes for oxygen imaging in vivo
    David Wilson; Fiscal Year: 2009
    ..e. ready for larger scale synthesis and rigorous toxicology studies preparatory to use in clinical trials. ..
  10. MATURATION OF CEREBROVASCULAR RELAXANT MECHANISMS
    William Pearce; Fiscal Year: 2009
    ..This approach should also identify which cGMP-dependent mechanisms may be most amenable to therapeutic pharmacological manipulation in the critically ill neonate. ..
  11. DOPAMINE/GLUTAMATE AND HYPOXIC INJURY IN NEWBORN BRAIN
    David Wilson; Fiscal Year: 2009
    ..This understanding will be the basis for more effective treatment of patients who have been subjected to a period(s) of insufficient oxygen delivery to the brain. ..
  12. Physiological Consequences of Hypoxia and Lung Disease
    Peter Wagner; Fiscal Year: 2008
    ..abstract_text> ..
  13. Respiratory Therapeutic Procedures in Panic Disorder
    Walton Roth; Fiscal Year: 2006
    ....
  14. Nitric Oxide/Carbon Monoxide in Pulmonary Hypertention
    Raed Dweik; Fiscal Year: 2006
    ..The training component of this proposal will lead to the candidate's transition to a fully independent investigator. ..
  15. PERIPHERAL CHEMORECEPTORS: MECHANISMS & MODULATIONS
    Sukhamay Lahiri; Fiscal Year: 2003
    ..The aim of this proposal is to understand how the processes are initiated in the chemosensory cells. ..
  16. MATURATION OF CEREBROVASCULAR CONTRACTILE MECHANISMS
    William Pearce; Fiscal Year: 2005
    ..abstract_text> ..
  17. MBRS RISE Program at the University of Hawaii at Hilo
    Daniel Brown; Fiscal Year: 2004
    ..Goal #4 of faculty development in research will be met by creating a summer program for collaborative studies at research universities and by greater institutional support for intramural research grants. ..
  18. Neurite density in skin as a marker for neuropathic pain
    Anne Louise Oaklander; Fiscal Year: 2005
    ..abstract_text> ..
  19. Oxygen Carriers for Hypovolemic Circulatory Collapse
    Robert Winslow; Fiscal Year: 2007
    ..The research described in this proposal will focus on molecules and formulations specifically tailored for use in prehospital and trauma settings. ..
  20. OXYGEN LEVELS AND RADIOSENSITIVITY IN TUMORS
    David Wilson; Fiscal Year: 2001
    ..Phosphors will be selected which can be injected intravenously and then, after the oxygen measurements, are excreted by the kidney. ..
  21. CHRONIC HYPOXIA, UTERINE ARTERY VASOREGULATION & GROWTH
    LORNA MOORE; Fiscal Year: 2003
    ..Aim #3 focuses on women residing at either low or high altitude in whom Doppler flow velocimetry and ultrasound imaging will be used to measure uterine artery blood flow. ..