anoxia

Summary

Summary: Clinical manifestation of respiratory distress consisting of a relatively complete absence of oxygen.

Top Publications

  1. pmc Hypoxia-inducible factors and the response to hypoxic stress
    Amar J Majmundar
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell 40:294-309. 2010
  2. pmc Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    Huafeng Zhang
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 283:10892-903. 2008
  3. ncbi Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
    Naomi Hosogai
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes 56:901-11. 2007
  4. ncbi Adipokines: inflammation and the pleiotropic role of white adipose tissue
    Paul Trayhurn
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
    Br J Nutr 92:347-55. 2004
  5. pmc Hypoxia-inducible factors, stem cells, and cancer
    Brian Keith
    Abramson Family Cancer Research Institute, University of Pennsylvania, 453 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cell 129:465-72. 2007
  6. ncbi Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure
    Kurt R Stenmark
    Univ of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1013-32. 2009
  7. ncbi Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    Rebecca J Appelhoff
    Henry Wellcome Bldg of Genomic Medicine, Roosevelt Drive, Headington, Oxford, UK
    J Biol Chem 279:38458-65. 2004
  8. pmc NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    Jordi Rius
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
    Nature 453:807-11. 2008
  9. ncbi Influence of cerebral and muscle oxygenation on repeated-sprint ability
    Kurt J Smith
    Integrative Physiology Unit, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Appl Physiol 109:989-99. 2010
  10. ncbi Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    Robert D Guzy
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Cell Metab 1:401-8. 2005

Detail Information

Publications354 found, 100 shown here

  1. pmc Hypoxia-inducible factors and the response to hypoxic stress
    Amar J Majmundar
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cell 40:294-309. 2010
    ..These transcription factors function in normal tissue homeostasis and impinge on critical aspects of disease progression and recovery. Insights from basic HIF biology are being translated into pharmaceuticals targeting the HIF pathway...
  2. pmc Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    Huafeng Zhang
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 283:10892-903. 2008
    ....
  3. ncbi Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
    Naomi Hosogai
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Diabetes 56:901-11. 2007
    ..Hypoxia also increased instability of adiponectin mRNA. Our results suggest that hypoperfusion and hypoxia in adipose tissues underlie the dysregulated production of adipocytokines and metabolic syndrome in obesity...
  4. ncbi Adipokines: inflammation and the pleiotropic role of white adipose tissue
    Paul Trayhurn
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
    Br J Nutr 92:347-55. 2004
    ....
  5. pmc Hypoxia-inducible factors, stem cells, and cancer
    Brian Keith
    Abramson Family Cancer Research Institute, University of Pennsylvania, 453 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cell 129:465-72. 2007
    ..As many cancers are thought to develop from a small number of transformed, self-renewing, and multipotent "cancer stem cells," these results suggest new roles for HIFs in tumor progression...
  6. ncbi Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure
    Kurt R Stenmark
    Univ of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1013-32. 2009
    ..This review highlights progress that has been made in animal modeling of this important human condition...
  7. ncbi Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    Rebecca J Appelhoff
    Henry Wellcome Bldg of Genomic Medicine, Roosevelt Drive, Headington, Oxford, UK
    J Biol Chem 279:38458-65. 2004
    ....
  8. pmc NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    Jordi Rius
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
    Nature 453:807-11. 2008
    ..IKK-beta is also essential for HIF-1alpha accumulation in macrophages experiencing a bacterial infection. Hence, IKK-beta is an important physiological contributor to the hypoxic response, linking it to innate immunity and inflammation...
  9. ncbi Influence of cerebral and muscle oxygenation on repeated-sprint ability
    Kurt J Smith
    Integrative Physiology Unit, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Appl Physiol 109:989-99. 2010
    ..By using a hypoxia paradigm, the study suggests that cerebral oxygenation contributes to the impairment of repeated-sprint ability...
  10. ncbi Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    Robert D Guzy
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Cell Metab 1:401-8. 2005
    ..These results demonstrate that mitochondria function as O(2) sensors and signal hypoxic HIF-1 alpha and HIF-2 alpha stabilization by releasing ROS to the cytosol...
  11. ncbi Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    Robert G Bristow
    Departments of Medical Biophysics and Radiation Oncology, University of Toronto and Ontario Cancer Institute and Princess Margaret Hospital University Health Network, 610 University Avenue, Toronto, Ontario, M5G2M9, Canada
    Nat Rev Cancer 8:180-92. 2008
    ..Acute and chronic hypoxia might lead to different biology within the tumour and this might have a direct effect on the design of new therapies for the treatment of hypoxic tumours...
  12. ncbi Hypoxia and cancer
    M Christiane Brahimi-Horn
    Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189, Nice, France
    J Mol Med (Berl) 85:1301-7. 2007
    ..It is hoped that a better understanding of the mechanisms implicated will lead to alternative and more efficient therapeutic approaches...
  13. pmc MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
    Stephen Y Chan
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 10:273-84. 2009
    ..These results identify important mechanistic connections among microRNA, iron-sulfur cluster biology, hypoxia, and mitochondrial function, with broad implications for cellular metabolism and adaptation to cellular stress...
  14. ncbi Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    G L Semenza
    Center for Medical Genetics, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Biol Chem 271:32529-37. 1996
    ..These results provide further evidence that the coordinate transcriptional activation of genes encoding glycolytic enzymes which occurs in hypoxic cells is mediated by HIF-1...
  15. pmc Significant molecular and systemic adaptations after repeated sprint training in hypoxia
    Raphaël Faiss
    ISSUL Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland
    PLoS ONE 8:e56522. 2013
    ..01) in RSH. Our findings show larger improvement in repeated sprint performance in RSH than in RSN with significant molecular adaptations and larger blood perfusion variations in active muscles...
  16. ncbi Regulation of oxygen homeostasis by hypoxia-inducible factor 1
    Gregg L Semenza
    Vascular Program, Institute for Cell Engineering, McKusick Nathans Institute of Genetic Medicine, Baltimore, Maryland, USA
    Physiology (Bethesda) 24:97-106. 2009
    ..HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively...
  17. ncbi HIF-1: mediator of physiological and pathophysiological responses to hypoxia
    G L Semenza
    Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
    J Appl Physiol (1985) 88:1474-80. 2000
    ..Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders...
  18. ncbi Biology of HIF-1alpha
    A Weidemann
    Division of Biological Sciences, Molecular Biology Section, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Death Differ 15:621-7. 2008
    ..The transcriptional complex hypoxia-inducible factor has emerged as a key regulator of the molecular hypoxic response, mediating a wide range of physiological and cellular mechanisms necessary to adapt to reduced oxygen...
  19. ncbi Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure
    Masaomi Nangaku
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Soc Nephrol 17:17-25. 2006
    ..This has given hope for the development of novel therapeutic approaches against this final common pathway...
  20. ncbi hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer
    Carme Camps
    Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford, United Kingdom
    Clin Cancer Res 14:1340-8. 2008
    ..We examined hypoxia-induced miRNA expression changes to identify markers of survival in breast cancer...
  21. ncbi Hypoxic pulmonary vasoconstriction
    J T Sylvester
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, Maryland, USA
    Physiol Rev 92:367-520. 2012
    ..Although understanding of HPV has advanced significantly, major areas of ignorance and uncertainty await resolution...
  22. ncbi Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    Peter Staller
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 425:307-11. 2003
    ....
  23. ncbi Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    Selma Pennacchietti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    Cancer Cell 3:347-61. 2003
    ..These data show that hypoxia promotes tumor invasion by sensitizing cells to HGF stimulation, providing a molecular basis to explain Met overexpression in cancer...
  24. ncbi Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    Craig Murdoch
    Tumor Targeting Group, Academic Unit of Pathology, Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, United Kingdom
    Blood 104:2224-34. 2004
    ....
  25. pmc Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Proc Natl Acad Sci U S A 107:11459-64. 2010
    ..Whichever of these explanations is correct, the evidence for genetic selection at the EPAS1 locus from the GWADS study is supported by the replicated studies associating function with the allelic variants...
  26. ncbi Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
    Dominador J Manalo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 105:659-69. 2005
    ....
  27. ncbi Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    Kurt R Stenmark
    Department of Pediatrics, Developmental Lung Biology Laboratory, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 99:675-91. 2006
    ..This review provides perspectives on each of the aforementioned areas...
  28. ncbi Reactive oxygen species: a breath of life or death?
    John P Fruehauf
    Department of Medicine, Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, California 92668, USA
    Clin Cancer Res 13:789-94. 2007
    ..This review will cover recent work in ROS-mediated signaling in cancer cells and its potential as a target for developmental therapeutics...
  29. ncbi HIF-1 and mechanisms of hypoxia sensing
    G L Semenza
    Johns Hopkins Hospital, CMSC 1004, 600 North Wolfe Street, Baltimore, Maryland 21287 3914, USA
    Curr Opin Cell Biol 13:167-71. 2001
    ..The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1 alpha under non-hypoxic conditions but inhibits hypoxia-induced HIF-1 alpha expression...
  30. pmc HIF-1alpha induces cell cycle arrest by functionally counteracting Myc
    Minori Koshiji
    Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 23:1949-56. 2004
    ..Hence, we propose that Myc is an integral part of a novel HIF-1alpha pathway, which regulates a distinct group of Myc target genes in response to hypoxia...
  31. pmc Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity
    Sarah R Walmsley
    Division of Respiratory Medicine, Department of Medicine, School of Clinical Medicine, University of Cambridge, Addenbrooke s and Papworth Hospitals, Cambridge, CB2 2QQ, UK
    J Exp Med 201:105-15. 2005
    ..In addition, we identify macrophage inflammatory protein-1beta as a novel hypoxia-induced neutrophil survival factor...
  32. pmc The heat-inducible transcription factor HsfA2 enhances anoxia tolerance in Arabidopsis
    Valeria Banti
    Plant Lab, Scuola Superiore Sant Anna, 56127 Pisa, Italy
    Plant Physiol 152:1471-83. 2010
    b>Anoxia induces several heat shock proteins, and a mild heat pretreatment can acclimatize Arabidopsis (Arabidopsis thaliana) seedlings to subsequent anoxic treatment...
  33. pmc miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer
    Antonis Giannakakis
    Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 7:255-64. 2008
    ..Taken together, our results indicate that miR-210 plays a crucial role in tumor onset as a key regulator of the hypoxia response and provide evidence for a link between hypoxia and the regulation of cell cycle...
  34. pmc Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    E Schipani
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Genes Dev 15:2865-76. 2001
    ....
  35. ncbi Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells
    Denis Mottet
    Laboratory of Biochemistry and Cellular Biology, University of Namur, 61 rue de Bruxelles, 5000 Namur, Belgium
    J Biol Chem 278:31277-85. 2003
    ....
  36. pmc miR-210: the master hypoxamir
    Yuk C Chan
    Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Microcirculation 19:215-23. 2012
    ....
  37. ncbi "Live high-train low" using normobaric hypoxia: a double-blinded, placebo-controlled study
    Christoph Siebenmann
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland
    J Appl Physiol (1985) 112:106-17. 2012
    ..In conclusion, 4 wk of LHTL, using 16 h/day of normobaric hypoxia, did not improve endurance performance or any of the measured, associated physiological variables...
  38. ncbi Red cell volume expansion at altitude: a meta-analysis and Monte Carlo simulation
    Peter Rasmussen
    Zurich Center of Integrative Human Physiology, Institute of Physiology, Zurich, Switzerland
    Med Sci Sports Exerc 45:1767-72. 2013
    ..The time course and the contribution of the red cell volume expansion are not clear. The purpose of the present meta-analysis was to explore how much altitude exposure is required to induce polycythemia in healthy lowlanders...
  39. ncbi Oncogenic alterations of metabolism
    C V Dang
    Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Trends Biochem Sci 24:68-72. 1999
    ....
  40. ncbi Does 'altitude training' increase exercise performance in elite athletes?
    Carsten Lundby
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Br J Sports Med 46:792-5. 2012
    ..Another aim is to encourage investigators to design well-controlled studies that will enhance our understanding of the mechanisms and potential benefits of altitude training...
  41. pmc MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU
    Elena Favaro
    Genomics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    PLoS ONE 5:e10345. 2010
    ..Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis...
  42. pmc Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue
    Nils Halberg
    Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell Biol 29:4467-83. 2009
    ..Collectively, our observations are consistent with a model in which adipose tissue hypoxia serves as an early upstream initiator for adipose tissue dysfunction by inducing a local state of fibrosis...
  43. ncbi Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    C Chen
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:9519-25. 2001
    ..Collectively these results indicate that H-Ras up-regulates the glut1 promoter, at least in part, by increasing HIF-1alpha protein levels leading to transactivation of promoter through the HIF-1 binding site...
  44. pmc Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response
    Magdalena Pasarica
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Diabetes 58:718-25. 2009
    ..Based on rodent studies, we examined the hypothesis that increased adipose tissue (AT) mass in obesity without an adequate support of vascularization might lead to hypoxia, macrophage infiltration, and inflammation...
  45. ncbi Hypoxia is important in the biology and aggression of human glial brain tumors
    Sydney M Evans
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6072, USA
    Clin Cancer Res 10:8177-84. 2004
    ..1% oxygen) was present in 5 of 12 grade 4 tumors. A correlation between more rapid tumor recurrence and hypoxia was demonstrated with EF5 binding, but this relationship was not predicted by Eppendorf measurements...
  46. ncbi How can we overcome tumor hypoxia in radiation therapy?
    Hiroshi Harada
    Group of Radiation and Tumor Biology, Career Path Promotion Unit for Young Life Scientists, Kyoto University, Japan
    J Radiat Res 52:545-56. 2011
    ....
  47. ncbi Hypoxia-inducible factor 1 (HIF-1) pathway
    Gregg L Semenza
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 North Broadway, Baltimore, MD 21205, USA
    Sci STKE 2007:cm8. 2007
    ..A growing number of proteins and small molecules have been identified that regulate HIF-1 activity by modulating the physical or functional interaction of PHD2, VHL, FIH-1, RACK1, or HSP90 with HIF-1alpha...
  48. ncbi Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline
    Paola Caruso
    Division of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, 126 University Ave, University of Glasgow, Glasgow, Scotland
    Arterioscler Thromb Vasc Biol 30:716-23. 2010
    ..Each miRNA is capable of potentially controlling hundreds of genes. The regulation of miRNAs in the lung during the development of pulmonary arterial hypertension (PAH) is unknown...
  49. pmc An integrated approach for experimental target identification of hypoxia-induced miR-210
    Pasquale Fasanaro
    IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy
    J Biol Chem 284:35134-43. 2009
    ..Given the complexity of miRNA actions, we view such a multiprong approach as useful to adequately describe the multiple pathways regulated by miR-210 during physiopathological processes...
  50. ncbi Signal transduction to hypoxia-inducible factor 1
    Gregg Semenza
    Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 1004, Baltimore, MD 21287 3914, USA
    Biochem Pharmacol 64:993-8. 2002
    ....
  51. ncbi Time course of haemoglobin mass during 21 days live high:train low simulated altitude
    Sally A Clark
    Department of Physiology, Australian Institute of Sport, PO Box 176, Belconnen, ACT, 2616, Australia
    Eur J Appl Physiol 106:399-406. 2009
    ..04, P = 0.89) between the increase in sEPO and the increase in Hb(mass). Athletes seeking to gain erythropoietic benefits from moderate altitude need to spend >12 h/day in hypoxia...
  52. ncbi Mechanisms of spreading depression and hypoxic spreading depression-like depolarization
    G G Somjen
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Physiol Rev 81:1065-96. 2001
    ..Short bouts of SD and HSD are well tolerated, but prolonged depolarization results in lasting loss of neuron function. Irreversible damage can, however, be avoided if Ca(2+) influx into neurons is prevented...
  53. pmc Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia
    Linda F Thompson
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA
    J Exp Med 200:1395-405. 2004
    ..Vascular leakage secondary to hypoxia was reversed in part by adenosine receptor agonists or reconstitution with soluble 5'-nucleotidase. Together, our studies identify CD73 as a critical mediator of vascular leakage in vivo...
  54. ncbi Pulmonary hypertension in COPD
    A Chaouat
    Dept for Respiratory Diseases and Respiratory Intensive Care, Centre Hospitalier Universitaire de Nancy, Vandoeuvre les Nancy, France
    Eur Respir J 32:1371-85. 2008
    ..In the meantime, the treatment of cor pulmonale in chronic obstructive pulmonary disease continues to rest on supplemental oxygen and a variety of measures aimed at the relief of airway obstruction...
  55. ncbi A microRNA component of the hypoxic response
    R Kulshreshtha
    Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, MA 02111, USA
    Cell Death Differ 15:667-71. 2008
    ..Several HRMs exhibit induction in response to HIF activation, thus extending its repertoire of targets beyond translated genes. In the present review, we discuss the emerging roles of HRMs in oxygen deprivation in cancer context...
  56. ncbi p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
    D E Richard
    Institute of Signaling, Developmental Biology and Cancer Research, UMR CNRS 6543, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
    J Biol Chem 274:32631-7. 1999
    ..This interaction between HIF-1alpha and p42/p44 MAPK suggests a cooperation between hypoxic and growth factor signals that ultimately leads to the increase in HIF-1-mediated gene expression...
  57. pmc The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF
    Sophie Beyer
    Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
    J Biol Chem 283:36542-52. 2008
    ..Studies on ectopically expressed JMJD1A and JMJD2B indicate that both proteins retain their histone lysine demethylase activity in hypoxia and thereby might impact the hypoxic gene expression program...
  58. ncbi Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha
    Tokujiro Uchida
    Department of Physiology, INSERM U426, Faculte de Medecine Xavier Bichat, Universite Paris 7, 75870 Paris, Cedex 18, France
    J Biol Chem 279:14871-8. 2004
    ..This trans-regulation between HIF-1alpha and HIF-2alpha during hypoxia likely conveys target gene specificity...
  59. ncbi The role of hypoxia in development of the Mammalian embryo
    Sally L Dunwoodie
    Developmental Biology Division, Victor Chang Cardiac Research Institute, University of New South Wales, Sydney, NSW 2052, Australia
    Dev Cell 17:755-73. 2009
    ..This review describes how low oxygen and HIF affect gene expression, cell behavior, and ultimately morphogenesis of the embryo and placenta...
  60. pmc Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    Debra F Higgins
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:3810-20. 2007
    ....
  61. pmc Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress
    Mark W Dewhirst
    Radiation Oncology Department, Duke University Medical Center, Durham, Durham, NC 27710, USA
    Radiat Res 172:653-65. 2009
    ..Cycling hypoxia can influence angiogenesis, treatment responses and metastatic behavior. It represents an important and relatively less well understood feature of tumor biology that requires additional research...
  62. pmc Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
    Laura E Via
    Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20852, USA
    Infect Immun 76:2333-40. 2008
    ..Thus, three independent lines of evidence support the hypothesis that hypoxic microenvironments are an important feature of some lesions in these animal models of tuberculosis...
  63. pmc Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
    H J Marti
    Department of Molecular Cell Biology, the Max Planck Institute for Physiological and Clinical Research, Bad Nauheim, Germany
    Am J Pathol 156:965-76. 2000
    ..Exogenous support of this natural protective mechanism might lead to enhanced survival after stroke...
  64. ncbi Effectiveness of intermittent training in hypoxia combined with live high/train low
    Eileen Y Robertson
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Eur J Appl Physiol 110:379-87. 2010
    ..9%; +/-1.4%) immediately post-altitude. LH/TL+TH elicited greater enhancements in physiological capacities compared with TH, however, the transfer of benefits to time-trial performance was more variable...
  65. ncbi 'Go or grow': the key to the emergence of invasion in tumour progression?
    H Hatzikirou
    School of Health Information Sciences, University of Texas Health Science Center at Houston, 7000 Fannin, Houston, TX 77030, USA
    Math Med Biol 29:49-65. 2012
    ..We test this hypothesis with the help of a lattice-gas cellular automaton. Finally, we suggest possible therapies that could help prevent the progression towards malignancy and invasiveness of benign tumours...
  66. ncbi Upregulation of heme oxygenase-1 expression by hydroxysafflor yellow A conferring protection from anoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes
    Shan xin Liu
    Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qinchun Road, Hangzhou, 310003, China
    Int J Cardiol 160:95-101. 2012
    ..Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent to alleviate I/R injury, but the mechanisms underlying this therapeutic effect are unknown...
  67. pmc Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model
    Rachel E Nisbet
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Atlanta, Georgia 30033, USA
    Am J Respir Cell Mol Biol 42:482-90. 2010
    ....
  68. pmc Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha
    A Y Yu
    Institute of Genetic Medicine, Division of Pulmonary and Critical Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
    J Clin Invest 103:691-6. 1999
    ..These results indicate that partial HIF-1alpha deficiency has significant effects on multiple systemic responses to chronic hypoxia...
  69. pmc Experimental selection of hypoxia-tolerant Drosophila melanogaster
    Dan Zhou
    Department of Pediatrics, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:2349-54. 2011
    ..Unique analytical tools and genetic and bioinformatic strategies allowed us to discover that Notch activation plays a major role in this hypoxia tolerance in Drosophila melanogaster...
  70. ncbi miR-210: More than a silent player in hypoxia
    Cecilia Devlin
    Department of Medicine, Indiana University, Indianapolis, IN, USA
    IUBMB Life 63:94-100. 2011
    ..Such targets may broadly affect the evolution of tumors and other pathological settings, such as ischemic disorders. Harnessing the knowledge of miR-210's actions may lead to novel diagnostic and therapeutic approaches...
  71. pmc Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction
    Liming Wang
    The Keenan Research Centre at Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Invest 122:4218-30. 2012
    ..Based on these data, we propose that HPV originates at the alveolocapillary level, from which the hypoxic signal is propagated as endothelial membrane depolarization to upstream arterioles in a Cx40-dependent manner...
  72. ncbi Interleukin-1beta and tumor necrosis factor-alpha stimulate DNA binding of hypoxia-inducible factor-1
    T Hellwig-Burgel
    Institut fur Physiologie, Medizinische Universitat zu Lubeck, Lubeck, Germany
    Blood 94:1561-7. 1999
    ..Thus, cytokine-induced inhibition of EPO production is not mediated by impairment of HIF-1 function. We propose that HIF-1 may be involved in modulating gene expression during inflammation...
  73. ncbi Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat
    D Gozal
    Kosair Children s Hospital Research Institute, Departments of Pediatrics, Pharmacology, and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neurosci 21:2442-50. 2001
    ..Furthermore, EHYP impaired performance during acquisition of a cognitive spatial task without affecting sensorimotor function. Such changes may underlie components of the learning and memory impairments found in OSA...
  74. ncbi Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics
    Leon G Fine
    Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, California, USA
    Kidney Int 74:867-72. 2008
    ..The limited success of existing strategies in retarding chronic kidney disease mandates that these new avenues of treatment be explored...
  75. pmc Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    Kalindi Parmar
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:5431-6. 2007
    ....
  76. pmc Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea
    Sanja Jelic
    Columbia University College of Physicians and Surgeons, Division of Pulmonary, Allergy, and Critical Care Medicine, PH8 Center, Room 840, 630 W 168th St, New York, NY 10032, USA
    Circulation 117:2270-8. 2008
    ..The effects of continuous positive airway pressure (CPAP) therapy on endothelial function and repair capacity were assessed...
  77. ncbi Impact of tumor hypoxia and anemia on radiation therapy outcomes
    Louis B Harrison
    Department of Radiation Oncology, Continuum Cancer Centers of New York, Beth Israel Medical Center, 10 Union Square East, New York, NY 10003, USA
    Oncologist 7:492-508. 2002
    ..Nonetheless, the correction of anemia may be a worthwhile strategy for radiation oncologists to improve local control and survival...
  78. ncbi Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo
    Harly Greenberg
    Division of Pulmonary, Critical Care and Sleep Medicine, Long Island Jewish Medical Center, The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, NY, USA
    Biochem Biophys Res Commun 343:591-6. 2006
    ..Thus, CIH-mediated NF-kappaB activation may be a molecular mechanism linking OSA and cardiovascular pathologies seen in OSA patients...
  79. ncbi Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome
    Silke Ryan
    Sleep Research Laboratory, St Vincent s University Hospital, Dublin, Ireland
    Circulation 112:2660-7. 2005
    ..We investigated the underlying molecular mechanisms of this association in a translational study...
  80. pmc HIF-1alpha expression regulates the bactericidal capacity of phagocytes
    Carole Peyssonnaux
    Division of Biological Sciences, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Clin Invest 115:1806-15. 2005
    ..HIF-1alpha control of myeloid cell activity in infected tissues could represent a novel therapeutic target for enhancing host defense...
  81. pmc Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange
    Norbert Weissmann
    University of Giessen Lung Center UGLC, Department of Internal Medicine II V, Klinikstrasse 36, 35392 Giessen, Germany
    Proc Natl Acad Sci U S A 103:19093-8. 2006
    ..We conclude that TRPC6 plays a unique and indispensable role in acute hypoxic pulmonary vasoconstriction. Manipulation of TRPC6 function may thus offer a therapeutic strategy for the control of pulmonary hemodynamics and gas exchange...
  82. ncbi Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels
    Evangelos D Michelakis
    Department of Medicine, University of Alberta, Edmonton, Canada
    Circulation 105:244-50. 2002
    ..We hypothesized that dichloroacetate (DCA), a metabolic modulator that can shift redox balance toward an oxidized state and increase Kv current in myocardial cells, would reverse CH-PHT...
  83. ncbi Muscle tissue adaptations to hypoxia
    H Hoppeler
    Department of Anatomy, University of Bern, Buhlstrasse 26, CH 3000 Bern 9, Switzerland
    J Exp Biol 204:3133-9. 2001
    ..In addition to the positive effects of hypoxia training on athletic performance, there is some recent indication that hypoxia training has a positive effect on the risk factors for cardiovascular disease...
  84. ncbi Oxidative stress in rat testis and epididymis under intermittent hypobaric hypoxia: protective role of ascorbate supplementation
    Jorge Gonzalo Farias
    Instituto de Biotecnología de Tarapacá, Universidad Arturo Prat, Av Arturo Prat 2120, Iquique, Chile
    J Androl 31:314-21. 2010
    ..This protection by AA of the IHH-induced lipid peroxidation can be explained in part by the preservation of glutathione reductase activity in these organs...
  85. pmc Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
    Bohan Wang
    Obesity Biology Unit Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University Clinical Departments, University of Liverpool, Liverpool, UK
    Pflugers Arch 455:479-92. 2007
    ..Hypoxia may underlie the development of the inflammatory response in adipocytes, leading to obesity-associated diseases...
  86. ncbi Interleukin-6 overexpression induces pulmonary hypertension
    M Kathryn Steiner
    Division of Pulmonary Critical Care Medicine, University of Massachusetts Memorial Medical Center, Worcester, MA 01655, USA
    Circ Res 104:236-44, 28p following 244. 2009
    ..These findings suggest that IL-6 promotes the development and progression of pulmonary vascular remodeling and PAH through proproliferative antiapoptotic mechanisms...
  87. ncbi Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells
    Warren L Grayson
    Department of Chemical and Biomedical Engineering, FAMU FSU College of Engineering, 2525 Pottsdamer Street, Tallahassee, FL 32310, USA
    Biochem Biophys Res Commun 358:948-53. 2007
    ..The results from this study demonstrated that oxygen concentrations affected many aspects of stem-cell physiology, including growth and in vitro development, and may be a critical parameter during expansion and differentiation...
  88. ncbi Flow-mediated vasodilation is impaired in adult rat offspring exposed to prenatal hypoxia
    J S Morton
    Dept of Obstetrics Gynaecology and Physiology, Univ of Alberta, Edmonton, Alberta, Canada
    J Appl Physiol (1985) 110:1073-82. 2011
    ..01). A change in the mechanisms of vasodilation occurring at an earlier age in IUGR offspring may predispose them to develop cardiovascular diseases as an aging adult...
  89. ncbi Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification
    Makoto Hirao
    Department of Orthopaedics, Osaka University Graduate School of Medicine, 2 2 Yamadoaka, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:31079-92. 2006
    ..These hypoxia-induced phenomena may act on chondrocytes to enhance and preserve their phenotype and function during chondrocyte differentiation and endochondral ossification...
  90. pmc The zebrafish embryo as a dynamic model of anoxia tolerance
    Bryce A Mendelsohn
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 237:1780-8. 2008
    ..These observations permit mechanistic insight into energy homeostasis during development that now enable genetic and small molecule screens in this vertebrate model of anoxia tolerance.
  91. ncbi Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting
    Lazaro Centanin
    Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Dev Cell 14:547-58. 2008
    ..We propose that the autonomous response to hypoxia that occurs in tracheal cells enhances tracheal sensitivity to increasing Branchless levels, and that this mechanism is a cardinal step in hypoxia-dependent tracheal sprouting...
  92. ncbi Selected Contribution: Pulmonary hypertension in mice following intermittent hypoxia
    K A Fagan
    Cardiovascular Pulmonary Research Laboratory, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Appl Physiol (1985) 90:2502-7. 2001
    ..We conclude that mice develop pulmonary hypertension following IH, representing a possible animal model of pulmonary hypertension in response to the repetitive hypoxia-reoxygenation of sleep apnea...
  93. ncbi Intermittent hypoxia: cell to system
    N R Prabhakar
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Physiol Lung Cell Mol Physiol 281:L524-8. 2001
    ..Chronic intermittent hypoxia leads to sustained elevation in arterial blood pressure and is associated with upregulation of catecholaminergic and renin-angiotensin systems and downregulation of nitric oxide synthases...
  94. pmc Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity
    Nao Iiyori
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Respir Crit Care Med 175:851-7. 2007
    ..Furthermore, we assessed the impact of IH on specific metabolic function in liver and muscle. Finally, we examined the potential mechanistic role of the autonomic nervous system (ANS) in mediating insulin resistance in response to IH...
  95. ncbi Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia
    Jianguo Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Appl Physiol 102:557-63. 2007
    ..In conclusion, CIH leads to hypercholesterolemia and lipid peroxidation in the absence of obesity, and the degree of metabolic dysregulation is dependent on the severity of the hypoxic stimulus...
  96. ncbi HIF-1alpha is essential for myeloid cell-mediated inflammation
    Thorsten Cramer
    Molecular Biology Section, Division of Biological Sciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 112:645-57. 2003
    ..This role for HIF-1alpha demonstrates its direct regulation of survival and function in the inflammatory microenvironment...
  97. pmc The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice
    Rachel E Nisbet
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Center, Atlanta, Georgia, USA
    Am J Respir Cell Mol Biol 40:601-9. 2009
    ..These findings demonstrate that NADPH oxidase-derived ROS contribute to the development of pulmonary vascular remodeling and hypertension caused by CIH...
  98. pmc Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation
    Cormac T Taylor
    UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Physiol 586:4055-9. 2008
    ..Recent studies indicate that these pathways may represent important new therapeutic targets in diseases characterized by hypoxic inflammation...
  99. pmc Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis
    Heui Dong Park
    Department of Pathobiology, University of Washington, Seattle, WA 98195, USA
    Mol Microbiol 48:833-43. 2003
    ..Together, these results demonstrate that Rv3133c/DosR is a transcription factor of the two-component response regulator class, and that it is the primary mediator of a hypoxic signal within M. tuberculosis...
  100. pmc Adaptive sugar provisioning controls survival of C. elegans embryos in adverse environments
    Harold N Frazier
    Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA
    Curr Biol 19:859-63. 2009
    ..elegans to hyperosmotic conditions protects their offspring from these conditions but causes sensitivity to anoxia exposure...
  101. pmc Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling
    Lunyin Yu
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148, Boston, MA 02114 2696, USA
    Am J Respir Crit Care Med 177:1276-84. 2008
    ..However, a causal role for the NHE1 gene in pulmonary hypertension has not been determined...

Research Grants64

  1. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..hibernating and preconditioned heart tissue in the "Second Window of Protection" (SWOP), is protective against anoxia. In AIM #1, we hypothesize that UCP-2 protects mitochondria against anoxia-reoxygenation, by reducing superoxide ..
  2. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..e. exercise, irregular homeostatis, anoxia/hypoxia, diet etc.) contribute to interferences that lower sensor accuracy...
  3. Pain and Hypoxia in Premature Neonates
    DANILYN MAG AKAT ANGELES; Fiscal Year: 2012
    ..Specific Aim 4 will determine whether there is a positive correlation between biobehavioral markers of procedural pain and biochemical markers of hypoxia, oxidative stress, and cell injury. ..
  4. Contractile Regulation of Cardiocyte Protein Synthesis
    Paul J McDermott; Fiscal Year: 2013
    ..thereby exposing the myocardium to either an insufficient supply of oxygen (hypoxia) or a complete lack of oxygen (anoxia)...
  5. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    Ischemia-reperfusion (I-R) in organs or anoxia-reoxygenation (A-R) in cells leads to cell death, oxidant stress, and organ dysfunction...
  6. Correlative Multimodal Imaging of Cardiac Electrophysiology and Metabolism
    JOHN PETER contact WIKSWO; Fiscal Year: 2010
    ..instruments, and extending the approach to allow the study of regional hyperkalemia, hypoglycemia, anoxia, and ischemia...
  7. Role of Astrocytic TREK-2 Potassium Channels in Cerebral Ischemia
    Misty J Eaton; Fiscal Year: 2013
    ..astrocytes to help maintain extracellular glutamate and K+ concentrations low during pathological events such as anoxia, ischemia, hypoxia, hypoglycemia and/or spreading depression...
  8. Cellular Biomechanics of Heat-Shock Induced Defects in Drosophila Embryogenesis
    M Shane Hutson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Non-specific environmental stress in early embryogenesis, e.g. heat shock, anoxia or chemical exposure, can lead to remarkably specific developmental defects...
  9. Modulation of GABAB receptor signaling
    Stephen J Moss; Fiscal Year: 2010
    ..cellular levels of ATP and in mediating cellular responses to metabolic stressors that include ischemia and anoxia. Transient anoxia also increases AMPK-phosphorylation of GABAB receptors and neuronal survival after this trauma...
  10. Pharmacological targeting of the Unfolded Protein Response as an antitumor strate
    Constantinos Koumenis; Fiscal Year: 2012
    Hypoxia/anoxia is a well-characterized component of the microenvironment of most solid tumor...
  11. Prenatal Exposure to Solid Fuel Smoke and Birth Outcomes in Sri Lanka
    Nalini Sathiakumar; Fiscal Year: 2011
    ..5), both known to cause fetal anoxia. However, the evidence linking indoor smoke to and adverse pregnancy outcomes is limited and sometimes conflicting;..
  12. Mitchondria-Nuclear Crosstalk in Hypoxic Gene Induction
    ROBERT POYTON; Fiscal Year: 2009
    ..in yeast to ask if mammalian cells experience transient oxidative or nitrosative stress when exposed to hypoxia or anoxia and, if so, identify proteins carbonylated or tyrosine nitrated under anoxic or hypoxic conditions...
  13. Stem Cells in Cardiac Repair and Angiogenesis
    Muhammad Ashraf; Fiscal Year: 2013
    ..Similarly when subjected to anoxia, younger MSCs showed more resistance and survived better as indicated by low level LDH release (an indicator of ..
  14. Na/Bicarbonate Cotransporters in Brain
    MARK OLIVER BEVENSEE; Fiscal Year: 2010
    ..The information \,;;1\ enhance our understa nding of acid -base handling by brain cells, partieul arly in acid-base disturbances associ:Jted \,;;th ischemia, anoxia/ hypoxia, stroh, and reperftlsion inj ury.
  15. NEUTROPHILS AND HEPATOTOXICITY
    ROBERT ANDREW ROTH; Fiscal Year: 2010
    ..Understanding how neutrophils interact with oxygen deficiency to promote liver injury could lead to better ways to prevent or treat adverse drug reactions and other types of inflammatory liver injury. ..
  16. Angiomyogenesis with HIF-1a responsive microRNAs
    RAFEEQ HABEEBAHMED; Fiscal Year: 2012
    ..are down- or upregulated in mesenchymal stem cells (MSCs) during reprogramming by intermittent cycles of brief anoxia/re-oxygenation (A/R) in parallel with activation of HIF-11...
  17. Stable isotopic and metabolomic studies in a model of lactic acidosis tolerance
    Daniel E Warren; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The goal of the proposed research is to use the profoundly anoxia and acidosis-resistant painted turtle to better understand the basic processes underlying vertebrate anaerobic metabolism, which is ..
  18. The Role of phosphoenolpyruvate carboxykinase and reactive oxygen species in the
    JASON EARL PODRABSKY; Fiscal Year: 2013
    ..of the annual killifish Austrofundulus limnaeus are an excellent model for investigating the mechanistic basis of anoxia-tolerance and anoxia-sensitivity in vertebrates. Embryos of A...
  19. Regulation of CD8 immunity to intracellular infections
    Ananda W Goldrath; Fiscal Year: 2013
    ..Furthermore, we will study the clinical relevance of pharmacologic stabilization of HIF, a molecule targeted in numerous disease contexts, to CD8+ T cell function. ..
  20. Basic Mechanisms of the Epilepsies Workshops
    Antonio Delgado Escueta; Fiscal Year: 2009
    ..g., prolonged febrile seizures, one or repeated seizures, birth anoxia-asphyxia hemorrhage, postnatal head trauma, neurocysticercosis, a stroke, and aging brains)...
  21. Optimal design of challenge-response experiments in cardiac electrophysiology
    MATTHEW STEPHEN SHOTWELL; Fiscal Year: 2013
    ..We observed the time course of cardiac action potential duration (APD) as a result of intermittent cardiac anoxia, a metabolic challenge that simulates asphyxia...
  22. DIVALENT CATIONS AND CARDIAC LIPID METABOLISM
    MARGARET WEIS; Fiscal Year: 1990
    The Mg2+ content of the heart is significantly reduced during acute hypoxia/anoxia and during Ca2+ deprivation (a model for acute ischemic states), suggesting that Mg2+ loss may mediate the pathophysiological changes that accompany acute ..
  23. Control of Synaptic Glutamate Release
    Steven J Mennerick; Fiscal Year: 2013
    ..We also evaluate the long-term implications of anoxia-induced silencing on subsequent network activity...
  24. Molecular mechanisms of oxidative stress resistance in an animal model of aging w
    Sarah Milton; Fiscal Year: 2009
    ..has provided new insights into the defense against oxidative stress as certain species survive prolonged bouts of anoxia and repeated reoxygenation without apparent cellular damage...
  25. Reactive nitrogen species in hypoxic fetal brain injury
    Sidhartha Tan; Fiscal Year: 2007
    ..abstract_text> ..
  26. CONTROL OF CEREBRAL REPERFUSION AFTER CARDIAC ARREST
    Peter Safar; Fiscal Year: 1990
    Cerebral neurons can probably tolerate at least 20 min of normothermic anoxia. After cardiac arrest (CA) of more than 5 min and cardiopulmonary resuscitation (CPR), however, the "post- resuscitation syndrome" of multiple organ systems ..
  27. GLUTAMATE TRANSPORT IN EXCITOTOXIC CELL DEATH
    Margaret Sutherland; Fiscal Year: 1999
    ..regulation of glutamate transporter gene expression during periods of neuronal insult associated with ischemia, anoxia, epilepsy, amyotrophic lateral sclerosis and psychiatric disorders such as schizophrenia results in excitotoxic ..
  28. PATHOGENESIS OF LIVER CELL NECROSIS
    John Farber; Fiscal Year: 2005
    ..death following an inhibition of mitochondrial electron transport, as a consequence most importantly of ischemia anoxia, over the last three years we have studied five models of apoptosis...
  29. STRETCH CHANGES IN THE RABBIT CERVIX BY PROSTAGLANDIN
    John Conrad; Fiscal Year: 1980
    ..If ordinary dilatation is lacking; obstructive labor takes place causing fetal anoxia or worse...
  30. RICKETTSIAL EFFECTS ON ENDOTHELIAL FUNCTIONS
    Thomas Walker; Fiscal Year: 1990
    ..The results of these changes are hypotension decreased blood volume, tissue anoxia, and shock due to peripheral vascular collapse...
  31. Role of C5a versus C5b-9 in Myocardial Ischemia and Reperfusion Injury
    Benjamin Guikema; Fiscal Year: 2007
    ..These aims will be addressed by subjecting adult rat ventricular myocytes (ARVM) to anoxia and reoxygenation in the presence of rat serum from wild type animals or animals lacking C6 and are therefore ..
  32. ISCHEMIA/REPERFUSION INJURY IN SURGERY AND TRAUMA
    Nicholas Vedder; Fiscal Year: 2000
    ..endothelium, stimulated by direct PKC activation, pro-adhesive mediators of ischemia-reperfusion, and cellular anoxia and reoxygenation. The effect of PKC inhibition on PMN beta2- integrin expression will also be examined in vitro...
  33. LEAD PHARMACOKINETICS AND TOXICITY
    Ho Leung Fung; Fiscal Year: 1980
    ..73 plus or minus 0.41 ng/min; mean plus or minus SE, n equals 9) was slightly reduced by either anoxia (1.75 plus or minus 0.08; n equals 7, p less then 0.10) or 0.02 M NaF (1.20 plus or minus 0...
  34. ANOXIA RESPONSIVE VL30 ELEMENTS
    Garth Anderson; Fiscal Year: 1992
    Our central objectives are to understand why anoxia induces normal rat fibroblasts to express very high levels of retrovirus/retrotransposon related VL30 element RNA, and to understand the relationship of this process to malignant ..
  35. Depolarization-induced Ca Stores Release in CNS Axons
    Peter Stys; Fiscal Year: 2006
    ..2) To study the mechanisms of Ca release from ER in myelinated axons and glia under pathological conditions (eg, anoxia, ischemia), with a focus on the interaction between DHPRs and RyRs...
  36. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 2001
    ..electrical stimulation, trauma such as physical puncture of the brain or applied pressure, or by anoxia/asphyxia...
  37. Differential 02 Sensing in Right and Left hearts: Crosstalk with Ca-Signaling
    Shahrzad Movafagh; Fiscal Year: 2009
    ..Our main hypothesis is that anoxia/hypoxia differentially alters calcium signaling in right versus left ventricles...
  38. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2003
    ..preparation from the turtle which takes advantage of this species' extraordinary resistance to anoxia. Using this preparation, conditioning of reflex pathways was undertaken simply by using electrical stimulation of ..
  39. Hypoxia and the Role of HIF-1 in the Ischemic Testis
    Michael Palladino; Fiscal Year: 2005
    ..pro-apoptotic role in the ischemic rat testis depending on the duration and extent of oxygen debt {hypoxia through anoxia)...
  40. OXIDATIVE INSULT TO CULTURED RENAL TUBULAR CELLS
    MICHAEL GOLIGORSKY; Fiscal Year: 1993
    ..b>Anoxia-reoxygenation, hydrogen peroxide and tert-butyl peroxide- induced changes in the above parameters of cell calcium ..
  41. PLASMALOGEN CATABOLISM DURNIG MYOCARDIAL ISCHEMIA
    David Ford; Fiscal Year: 1993
    ..phospholipid metabolism has never been directly demonstrated, alterations in the sarcolemmal compartment during anoxia and agonist stimulation will be assessed by specifically incorporating radiolabeled plasmalogens and diacyl ..
  42. Exercise Training and Myocardial K-ATP Channel Function
    RUSSELL MOORE; Fiscal Year: 2007
    ..We recently found that Tr elicits a marked reduction in the magnitude of an anoxia-inducible, glibenclamide-sensitive outward K current (IK,ATP) in single rat ventricular cardiocytes...
  43. ADRENERGIC CONTROL OF HEART & MUSCLE PHOSPHOFRUCTOKINASE
    TAG MANSOUR; Fiscal Year: 1990
    ..Because of the critical role it plays during anoxia, information about its modulation contributes to a better understanding of many cardiovascular and muscular ..
  44. BIOLOGY OF THE BLOOD BRAIN BARRIER
    William Pardridge; Fiscal Year: 1999
    ..to identify the subcellular localization of the BBB GLUT1 glucose transporter in pathologic states such as anoxia or ischemia. Project by K.L...
  45. ENDOTHELIAL CELL IN CORONARY VASOSPASM AND THROMBOSIS
    ROBERT HIGHSMITH; Fiscal Year: 1992
    ..Other investigators have shown that EDCF activity can be expressed by the intact endothelial lining and that anoxia enhances the release of a diffusable, polypeptide vasoconstrictor from intact vessels in an EC-dependent fashion...
  46. EXCITOTOXICITY--ROLE OF NON-NMDA RECEPTORS
    Richard Bridges; Fiscal Year: 1991
    ..g. epilepsy, Huntington's disease, anoxia, ischemia, hypoglycemia)...
  47. Mitochondria and Cardiac Cell Death
    James Weiss; Fiscal Year: 2007
    ..In this revised application that two separable components predispose mitochondria to injury during anoxia/reoxygenation...
  48. CELLULAR IMMUNITY IN SICK AND MALNOURISHED INFANTS
    E Stiehm; Fiscal Year: 1991
    ..defenses, but also a yet not well defined role in infection, intrauterine or postnatal malnutrition, hypogycemia, anoxia, etc...
  49. SUBSTANCE P-SPECIFIC CONDUCTING POLYMER ELECTRODE
    ANASTASIA BOGOMOLOVA; Fiscal Year: 2001
    ..are the key players in a variety of human responses to pain, stress, hemorrhage, transfusion, orthostasis and anoxia, and are affecting the immune system The concentration of a specific neuropeptide in a certain system of the body ..
  50. RESEARCH CENTER FOR CEREBRAL VASCULAR DISEASE
    MYRON GINSBERG; Fiscal Year: 2004
    ..serum albumin therapy, and of exacerbation of injury due to hyperthermia (fever); 2) mitochondria and cerebral anoxia/ischemia: basic mechanistic studies of protection and dysfunction; and 3) the metabolic and structural ..
  51. LIPOSOME MYOCARDIAL UPTAKE IN INFARCT AND ISCHEMIA
    VICENTE CARIDE; Fiscal Year: 1980
    ..Fetal mouse heart culture will permit the study of well controlled degrees of injury: anoxia, reversible and irreversible ischemia and situations of recovery...
  52. PERINATAL BRAIN DAMAGE--MECHANISMS AND PREVENTION
    John Olney; Fiscal Year: 1990
    ..of evidence suggest that endogenous EAA may cause or that EAA antagonists can prevent brain damage associated with anoxia/ischemia. Such evidence derives from both in vitro and in vivo research...
  53. NA/CA2 EXCHANGE AND CAI IN THE PROXIMAL TUBULE
    Jesus Dominguez; Fiscal Year: 1990
    ..Two, in the rat proximal tubule, anoxia alters the homeostatic interdependence of Ca2+ and Na+...
  54. SGP-2 (CLUSTERIN) AND REPRODUCTION
    Michael Griswold; Fiscal Year: 2003
    ..and the basal level of secretion is greatly increased under conditions of cellular stress such as heat shock or anoxia. In addition, it accumulates in apoptotic germ cells in the testis but it is synthesized primarily by the Sertoli ..
  55. BIOSYNTHESIS AND FUNCTIONS OF ANIMAL CELL PLASMALOGENS
    RAPHAEL ZOELLER; Fiscal Year: 2001
    ..cells are hypersensitive to chemical hypoxia (a chemical model for ischemia/ reperfusion), as well as anoxia/reoxygenation...
  56. Neuronal basis of courtship specificity and plasticity
    Toshihiro Kitamoto; Fiscal Year: 2006
    ..and memory, can occur for a number of reasons including brain surgery, chronic alcohol abuse, head injury, anoxia, and various neurodegenerative disorders such as Alzheimer's disease...
  57. Selective Prenatal Dopamine Damage in Non Human Primates
    John Elsworth; Fiscal Year: 2003
    ..developmental abnormalities may occur as a result of genetics, drug abuse, environmental toxins, physical trauma, anoxia or infection...
  58. ISCHEMIC INJURY OF NEONATAL CNS WHITE MATTER GLIA
    Robert Fern; Fiscal Year: 2001
    ..from Applicant's Abstract): The proposed research will examine mechanisms of CNS white matter injury following anoxia- ischemia, which is of causal relevance to periventricular leukomalacia (PL), the most common neurological lesion ..
  59. RESEARCH CENTER IN CEREBROVASCULAR DISEASE
    Fred Plum; Fiscal Year: 1993
    ..studies examine cerebral energy metabolism and blood flow in evolving stroke, axoplasmic transport during anoxia-ischemia, and the effect of hypoxemia on acetylcholine metabolism in the brain...
  60. ELECTROPHYSIOLOGIC MECHANISMS--ISCHEMIC NEURONAL INJURY
    NORMAN HERSHKOWITZ; Fiscal Year: 1992
    b>Anoxia/ischemia will induce reversible changes in neurons that eventually become irreversible, and the cells die...
  61. Elevated Zinc in Ischemia and reperfusion
    Yang Li; Fiscal Year: 2006
    ..a disability caused by brain injury, the result of an either external physical force or internal causes such as anoxia, stroke/ischemic insult, Alzheimer disease, or epilepsy...
  62. POSTTRANSLATIONAL REGULATION OF HSF ACTIVITY
    James Bonner; Fiscal Year: 2002
    ..O2- is produced nonenzymatically during heat shock, and by mitochondrial activity during hypoxia or recovery from anoxia. The response to O2- shows that HSF is an immediate cellular defense against reperfusion injury, incurred ..
  63. CAN MICROGLIAL CELLS PREVENT NEURONAL INJURY?
    Annadora Bruce Keller; Fiscal Year: 2002
    ..e., seizure-induced damage), anoxia (i.e., stroke), and amyloid- dependent (i.e., Alzheimer s like pathology)...
  64. IONIC HOMEOSTASIS IN ANOXIC CARDIAC MUSCLE CELLS
    ROBERT HADLEY; Fiscal Year: 1999
    ..that the Na+ channel, the Na+/H+ exchanger, and the Na+/K+ pump make to the elevation of [Na+] during anoxia. 2) Test the hypothesis that the reoxygenation-induced Ca2+ spike is caused by the recovery of the Na+/Ca2+ ..