Summary: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.

Top Publications

  1. ncbi Reduction of fatigue in Sjögren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study
    S Dass
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Ann Rheum Dis 67:1541-4. 2008
  2. ncbi Post-stroke fatigue: qualitative study of three focus groups
    Nancy A Flinn
    Occupational Science and Occupational Therapy Department, College of St Catherine, St Paul, Minnesota 55105, USA nafl
    Occup Ther Int 17:81-91. 2010
  3. ncbi Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction
    Nicola Pavese
    Department of Medicine, Centre for Neuroscience, Imperial College, London, UK
    Brain 133:3434-43. 2010
  4. ncbi Fatigue in neurological disorders
    Abhijit Chaudhuri
    Division of Clinical Neurosciences, University of Glasgow, Glasgow G51 4TF, UK
    Lancet 363:978-88. 2004
  5. pmc High levels of untreated distress and fatigue in cancer patients
    L E Carlson
    Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Cancer Board, Calgary, Alberta, Canada
    Br J Cancer 90:2297-304. 2004
  6. ncbi Effect of Iyengar yoga practice on fatigue and diurnal salivary cortisol concentration in breast cancer survivors
    Jacquelyn Banasik
    College of Nursing, Washington State University, Spokane, Washington 99210 1495, USA
    J Am Acad Nurse Pract 23:135-42. 2011
  7. ncbi Match performance of high-standard soccer players with special reference to development of fatigue
    Magni Mohr
    Institute of Exercise and Sport Sciences, August Krogh Institute, Department of Human Physiology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen O, Denmark
    J Sports Sci 21:519-28. 2003
  8. ncbi Resveratrol protects against physical fatigue and improves exercise performance in mice
    Ruei Er Wu
    Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan
    Molecules 18:4689-702. 2013
  9. ncbi Effect of axitinib (AG-013736) on fatigue, thyroid-stimulating hormone, and biomarkers: a phase I study in Japanese patients
    Toru Mukohara
    National Cancer Center Hospital East, Oncology Hematology, Kashiwa, Japan
    Cancer Sci 101:963-8. 2010
  10. ncbi Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition
    G A Curt
    National Cancer Institute, Bethesda, Maryland 20892 0001, USA
    Oncologist 5:353-60. 2000

Detail Information

Publications392 found, 100 shown here

  1. ncbi Reduction of fatigue in Sjögren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study
    S Dass
    Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds, UK
    Ann Rheum Dis 67:1541-4. 2008
    Primary Sjögren syndrome (pSS) causes significant systemic symptoms including fatigue as well as glandular dysfunction...
  2. ncbi Post-stroke fatigue: qualitative study of three focus groups
    Nancy A Flinn
    Occupational Science and Occupational Therapy Department, College of St Catherine, St Paul, Minnesota 55105, USA nafl
    Occup Ther Int 17:81-91. 2010
    b>Fatigue affects many persons after cerebrovascular accident, particularly those with mild stroke...
  3. ncbi Fatigue in Parkinson's disease is linked to striatal and limbic serotonergic dysfunction
    Nicola Pavese
    Department of Medicine, Centre for Neuroscience, Imperial College, London, UK
    Brain 133:3434-43. 2010
    Disabling fatigue is a symptom in a number of neurological diseases, including multiple sclerosis, stroke and Parkinson's disease...
  4. ncbi Fatigue in neurological disorders
    Abhijit Chaudhuri
    Division of Clinical Neurosciences, University of Glasgow, Glasgow G51 4TF, UK
    Lancet 363:978-88. 2004
    Chronic fatigue is a typical symptom of neurological diseases, and is most disabling in multiple sclerosis, postpoliomyelitis, poststroke, and in chronic fatigue syndrome...
  5. pmc High levels of untreated distress and fatigue in cancer patients
    L E Carlson
    Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Cancer Board, Calgary, Alberta, Canada
    Br J Cancer 90:2297-304. 2004
    ..Many patients who report high levels of distress are not taking advantage of available supportive resources. Barriers to such use, and factors predicting distress and use of psychosocial care, require further exploration...
  6. ncbi Effect of Iyengar yoga practice on fatigue and diurnal salivary cortisol concentration in breast cancer survivors
    Jacquelyn Banasik
    College of Nursing, Washington State University, Spokane, Washington 99210 1495, USA
    J Am Acad Nurse Pract 23:135-42. 2011
    ..To examine the effect of regular Iyengar yoga practice on measures of self-perceived psychosocial function and diurnal salivary cortisol secretion in stage II-IV breast cancer survivors (n = 18)...
  7. ncbi Match performance of high-standard soccer players with special reference to development of fatigue
    Magni Mohr
    Institute of Exercise and Sport Sciences, August Krogh Institute, Department of Human Physiology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen O, Denmark
    J Sports Sci 21:519-28. 2003
    The aim of this study was to assess physical fitness, match performance and development of fatigue during competitive matches at two high standards of professional soccer...
  8. ncbi Resveratrol protects against physical fatigue and improves exercise performance in mice
    Ruei Er Wu
    Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan
    Molecules 18:4689-702. 2013
    ..However, there is limited evidence for the effects of RES on physical fatigue and exercise performance...
  9. ncbi Effect of axitinib (AG-013736) on fatigue, thyroid-stimulating hormone, and biomarkers: a phase I study in Japanese patients
    Toru Mukohara
    National Cancer Center Hospital East, Oncology Hematology, Kashiwa, Japan
    Cancer Sci 101:963-8. 2010
    ..One patient had dose-limiting toxicity (grade 3 proteinuria and fatigue). Common treatment-related adverse events were anorexia, fatigue, and diarrhea...
  10. ncbi Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition
    G A Curt
    National Cancer Institute, Bethesda, Maryland 20892 0001, USA
    Oncologist 5:353-60. 2000
    This survey was designed to confirm the prevalence and duration of fatigue in the cancer population and to assess its physical, mental, social, and economic impacts on the lives of patients and caregivers. Patients and Methods...
  11. ncbi Validation of the Functional Assessment of Chronic Illness Therapy Fatigue Scale relative to other instrumentation in patients with rheumatoid arthritis
    David Cella
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    J Rheumatol 32:811-9. 2005
    This study validated a brief measure of fatigue in rheumatoid arthritis (RA), the Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue Scale.
  12. ncbi Association of resident fatigue and distress with perceived medical errors
    Colin P West
    Division of General Internal Medicine, Department of Medicine, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    JAMA 302:1294-300. 2009
    b>Fatigue and distress have been separately shown to be associated with medical errors. The contribution of each factor when assessed simultaneously is unknown.
  13. ncbi Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration
    Pierre Alexandre Krayenbuehl
    Division of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Blood 118:3222-7. 2011
    This is the first study to investigate the efficacy of intravenous iron in treating fatigue in nonanemic patients with low serum ferritin concentration...
  14. pmc Self-report fatigue questionnaires in multiple sclerosis, Parkinson's disease and stroke: a systematic review of measurement properties
    Roy G Elbers
    Department of Physiotherapy, University of Applied Sciences Leiden, Zernikedreef 11, PO Box 382, 2300 AJ, Leiden, The Netherlands
    Qual Life Res 21:925-44. 2012
    To critically appraise, compare and summarize the measurement properties of self-report fatigue questionnaires validated in patients with multiple sclerosis (MS), Parkinson's disease (PD) or stroke.
  15. ncbi Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis
    Lena Melamud
    Division of Neuroimmunology and Multiple Sclerosis Center, Carmel Medical Center, Haifa, Israel
    J Neurol Sci 314:37-40. 2012
    Sleep disruption and fatigue are common in Multiple Sclerosis (MS). Melatonin is one of the major regulators of sleep-wake cycle...
  16. pmc Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy
    Benzi M Kluger
    Department of Neurology, University of Colorado Denver, Aurora, USA
    Neurology 80:409-16. 2013
    b>Fatigue is commonly reported in many neurologic illnesses, including multiple sclerosis, Parkinson disease, myasthenia gravis, traumatic brain injury, and stroke...
  17. ncbi Role of interleukin-6 in stress, sleep, and fatigue
    Nicolas Rohleder
    Department of Psychology and Volen National Center for Complex Systems, Brandeis University, Waltham, Massachusetts, USA
    Ann N Y Acad Sci 1261:88-96. 2012
    ..elevations in the context of inflammatory disease affect the organism, with a focus on sleep-related symptoms and fatigue; and conversely, how alterations in sleep duration and quality stimulate increased concentrations of IL-6 in the ..
  18. ncbi Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity
    Alexander Panossian
    Swedish Herbal Institute Research and Development, Spårvägen 2, SE 43296 Askloster, Sweden
    Curr Clin Pharmacol 4:198-219. 2009
    ..this review article is to assess the level of scientific evidence presented by clinical trials of adaptogens in fatigue, and to provide a rationale at the molecular level for verified effects...
  19. ncbi Physical impairment, depressive symptoms and pre-stroke fatigue are related to fatigue in the acute phase after stroke
    Anners Lerdal
    Department of Health Sciences, Buskerud University College, Drammen, Norway
    Disabil Rehabil 33:334-42. 2011
    The aim of this study was to describe prevalence of fatigue and its relationship with demographic and clinical variables during the first 2 weeks (acute phase) following a stroke.
  20. ncbi Poststroke fatigue--a review
    Anners Lerdal
    Department of Health Sciences, Buskerud University College, 3007 Drammen, Norway
    J Pain Symptom Manage 38:928-49. 2009
    Although fatigue is a common complaint after stroke, relatively little is known about how poststroke fatigue is experienced and what its related factors are...
  21. ncbi Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer
    Roanne J Segal
    Ottawa Hospital Regional Cancer Center University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Clin Oncol 27:344-51. 2009
    Radiotherapy for prostate cancer (PCa) may cause unfavorable changes in fatigue, quality of life (QOL), and physical fitness...
  22. ncbi Resistance exercise in men receiving androgen deprivation therapy for prostate cancer
    Roanne J Segal
    Department of Medical Oncology, Ottawa Regional Cancer Centre General Site, 503 Smyth Rd, Ottawa, Ontario K1H 1C4, Canada
    J Clin Oncol 21:1653-9. 2003
    Androgen deprivation therapy is a common treatment in men with prostate cancer that may cause fatigue, functional decline, increased body fatness, and loss of lean body tissue...
  23. ncbi The impact of hypogonadism and autonomic dysfunction on fatigue, emotional function, and sexual desire in male patients with advanced cancer: a pilot study
    Florian Strasser
    Section of Oncology Hematology, Department Internal Medicine, Cantonal Hospital, St Gallen, Switzerland
    Cancer 107:2949-57. 2006
    The objective of this study was to determine whether hypogonadism and autonomic dysfunction contribute substantially to cancer-related fatigue, decreased sexual desire, and depression in male patients with advanced, incurable cancer.
  24. ncbi Impact of mindfulness-based stress reduction (MBSR) on sleep, mood, stress and fatigue symptoms in cancer outpatients
    Linda E Carlson
    Department of Oncology, Department of Psychology, University of Calgary, Calgary, Alberta, Canada
    Int J Behav Med 12:278-85. 2005
    ..001). There was also a significant reduction in stress (p < .001), mood disturbance (p = .001), and fatigue (p < .001)...
  25. ncbi Poststroke fatigue: characteristics and related factors
    Smi Choi-Kwon
    College of Nursing, Seoul National University, Seoul, South Korea
    Cerebrovasc Dis 19:84-90. 2005
    Poststroke fatigue (PoSF) is a common, but poorly studied problem. The purpose of the present study was to elucidate the characteristics of and the factors associated with PoSF.
  26. ncbi Spinal modulations accompany peripheral fatigue during prolonged tennis playing
    O Girard
    Research and Education Center, ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital, Doha, Qatar
    Scand J Med Sci Sports 21:455-64. 2011
    ..H(max) /M(max) (P<0.001), H(sup) /M(sup) (P<0.01) and V/M(sup) (P<0.05) ratios were depressed with fatigue and decreased by ∼80%, 46% and 61% at the end of exercise, respectively...
  27. ncbi The effect of exercise therapy on fatigue in multiple sclerosis
    A K Andreasen
    Department of Neurology, Rigshospitalet, Denmark
    Mult Scler 17:1041-54. 2011
    b>Fatigue occurs in the majority of patients with multiple sclerosis (MS) and therapeutic possibilities are few...
  28. ncbi Interactive processes link the multiple symptoms of fatigue in sport competition
    Axel J Knicker
    German Sport University Cologne, Institute for Movement and Neurosciences, Cologne, Germany
    Sports Med 41:307-28. 2011
    Muscle physiologists often describe fatigue simply as a decline of muscle force and infer this causes an athlete to slow down...
  29. pmc Influence of brain catecholamines on the development of fatigue in exercising rats in the heat
    Hiroshi Hasegawa
    Laboratoruy of Exercise Physiology, Graduate School of Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi Hiroshima, Japan
    J Physiol 586:141-9. 2008
    ..Moreover, these results support previous findings in humans that acute bupropion ingestion increases T(core) during exercise in the heat, indicating the possibility of an important role for DA and NA in thermoregulation...
  30. pmc Measurement quality and validity of the "need for recovery scale"
    M van Veldhoven
    Department of Human Resource Studies, Tilburg University, Netherlands Dutch Foundation for Quality in Occupational Health Care SKB, Amsterdam, Netherlands
    Occup Environ Med 60:i3-9. 2003
    The "need for recovery scale" is suggested as an operationalisation for the measurement of (early symptoms of) fatigue at work. Definition of and background on the concept of need for recovery are briefly discussed...
  31. ncbi The assessment of fatigue: a practical guide for clinicians and researchers
    A J Dittner
    Department of Psychology, Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    J Psychosom Res 56:157-70. 2004
    b>Fatigue is a common feature of physical and neurological disease as well as psychiatric disorders, often reported amongst patients' most severe and distressing symptoms...
  32. ncbi Quantitative physiologically based modeling of subjective fatigue during sleep deprivation
    B D Fulcher
    School of Physics, University of Sydney, New South Wales 2006, Australia
    J Theor Biol 264:407-19. 2010
    A quantitative physiologically based model of the sleep-wake switch is used to predict variations in subjective fatigue-related measures during total sleep deprivation...
  33. pmc MS quality of life, depression, and fatigue improve after mindfulness training: a randomized trial
    P Grossman
    Department of Psychosomatic Medicine, Division of Internal Medicine, University Hospital Basel, Hebelstrasse 2, Basel, Switzerland
    Neurology 75:1141-9. 2010
    ..life (HRQOL) is often much reduced among individuals with multiple sclerosis (MS), and incidences of depression, fatigue, and anxiety are high...
  34. pmc Vitamin D status in patients with musculoskeletal pain, fatigue and headache: a cross-sectional descriptive study in a multi-ethnic general practice in Norway
    Kirsten Valebjørg Knutsen
    Department of General Practice and Community Medicine, Institute of Health and Society, University of Oslo, Norway
    Scand J Prim Health Care 28:166-71. 2010
    To investigate vitamin D levels in patients with non-specific musculoskeletal pain, headache, and fatigue.
  35. ncbi Quality of life, depression and fatigue in mildly disabled patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: 3-year results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study
    F Patti
    Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, University Hospital, Catania, Italy
    Mult Scler 17:991-1001. 2011
    The precise relationships among quality of life, depression, fatigue and cognitive impairment in multiple sclerosis (MS) are complex and poorly understood.
  36. ncbi Psychometric properties of the Fatigue Severity Scale-Rasch analyses of individual responses in a Norwegian stroke cohort
    Anners Lerdal
    Research Centre for Clinical Nursing Research, Lovisenberg Deaconal University College, Oslo, Norway
    Int J Nurs Stud 48:1258-65. 2011
    The psychometric properties of the Fatigue Severity Scale (FSS) have not been tested in people with stroke, despite its being the most frequently used instrument measuring fatigue in this population.
  37. ncbi L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism
    Tomohiro Sugino
    Soiken Inc, Toyonaka, Osaka 560 0082, Japan
    Nutr Res 28:738-43. 2008
    We examined the effects of L-ornithine administration on physical fatigue. In a double-blind, placebo-controlled, 2-way crossover study, 17 healthy volunteers were randomized to L-ornithine (2000 mg/d for 7 days and 6000 mg/d for 1 day ..
  38. ncbi Fatigue and basal ganglia
    A Chaudhuri
    Department of Neurology, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Road, G51 4TF, Scotland, Glasgow, UK
    J Neurol Sci 179:34-42. 2000
    b>Fatigue is a common symptom in neurology and occurs in the diseases of the central and peripheral nervous system...
  39. ncbi Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise
    Lars Nybo
    Institute of Exercise and Sport Sciences and Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Exerc Sport Sci Rev 35:110-8. 2007
    ..strenuous exercise, hyperventilation lowers the arterial carbon dioxide tension and blunts the increase in cerebral blood flow, which can lead to an inadequate oxygen delivery to the brain and contribute to the development of fatigue.
  40. pmc Association between pro- and anti-inflammatory cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression
    Julie Illi
    School of Nursing, University of California, San Francisco, CA 94143 0610, USA
    Cytokine 58:437-47. 2012
    ..were to determine: if distinct classes of individuals could be identified based on their experience with pain, fatigue, sleep disturbance, and depression; if these classes differed on demographic and clinical characteristics; and if ..
  41. ncbi Web-based tailored education program for disease-free cancer survivors with cancer-related fatigue: a randomized controlled trial
    Young Ho Yun
    National Cancer Center, Goyang, Korea
    J Clin Oncol 30:1296-303. 2012
    To determine whether an Internet-based tailored education program is effective for disease-free cancer survivors with cancer-related fatigue (CRF).
  42. pmc Fatigue before, during and after antiviral therapy of chronic hepatitis C: results from the Virahep-C study
    Souvik Sarkar
    Liver Disease Branch, Division of Intramural Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, United States
    J Hepatol 57:946-52. 2012
    b>Fatigue is the most frequent and often debilitating symptom of chronic hepatitis C. It is unclear whether successful therapy of hepatitis C leads to its clinical improvement...
  43. ncbi Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial
    Kerry S Courneya
    Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Alberta, Canada
    J Clin Oncol 25:4396-404. 2007
    ..We evaluated the relative merits of aerobic and resistance exercise in blunting these effects...
  44. ncbi A new hypothesis of chronic fatigue syndrome: co-conditioning theory
    Masaaki Tanaka
    Department of Physiology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Med Hypotheses 75:244-9. 2010
    Chronic fatigue syndrome is an illness characterized by a profound, disabling, and unexplained sensation of fatigue lasting at least 6 months, which severely impairs daily functioning and is accompanied by a combination of non-specific ..
  45. ncbi Exercise and fatigue
    Wim Ament
    Department of Biometrics, Faculty of Health and Technology, Zuyd University, Heerlen, The Netherlands
    Sports Med 39:389-422. 2009
    ..Depending on the form of exercise, sooner or later sensations of fatigue and exhaustion will occur...
  46. ncbi Ammonia metabolism, the brain and fatigue; revisiting the link
    Daniel J Wilkinson
    Department of Sport and Exercise Science, Chelsea School, University of Brighton, 30 Carlisle Road, Eastbourne, UK
    Prog Neurobiol 91:200-19. 2010
    This review addresses the ammonia fatigue theory in light of new evidence from exercise and disease studies and aims to provide a view of the role of ammonia during exercise...
  47. ncbi Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis
    Justin C Brown
    Department of Kinesiology, University of Connecticut, 2095 N Hillside Road, U 1110, Storrs, CT 06269, USA
    Cancer Epidemiol Biomarkers Prev 20:123-33. 2011
    ..meta-analysis was to explore the efficacy of exercise as a nonpharmacologic intervention to reduce cancer-related fatigue (CRF) among adult cancer survivors...
  48. ncbi Central inhibition regulates motor output during physical fatigue
    Masaaki Tanaka
    Department of Physiology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Brain Res 1412:37-43. 2011
    Central fatigue refers to a progressive decline in the ability to activate muscles voluntarily...
  49. ncbi Daily oral administration of crocetin attenuates physical fatigue in human subjects
    Hiroshi Mizuma
    Department of Physiology, Osaka City University Graduate School of Medicine, Osaka 545 8585, Japan
    Nutr Res 29:145-50. 2009
    ..effects of placebo with a carotenoid compound, crocetin, as well as an antioxidant, ascorbic acid, on physical fatigue in humans...
  50. ncbi Time course and risk factors of post-stroke fatigue: a prospective cohort study
    L Snaphaan
    Department of Neurology, Radboud University Nijmegen Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Eur J Neurol 18:611-7. 2011
    Post-stroke fatigue (PSF) often occurs after stroke and has a negative impact on the rehabilitation process. Several studies focused either on short- or on long-term PSF and their relations with stroke characteristics...
  51. ncbi Is fatigue after stroke associated with physical deconditioning? A cross-sectional study in ambulatory stroke survivors
    Susan J Lewis
    University of Edinburgh, Edinburgh, United Kingdom
    Arch Phys Med Rehabil 92:295-8. 2011
    To determine the relationship between a measure of fatigue and 2 indices of physical fitness, lower limb extensor power (LLEP) and walking economy.
  52. ncbi Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis
    Dewy van Hoogmoed
    Nijmegen Expert Centre of Chronic Fatigue, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Rheumatology (Oxford) 49:1294-302. 2010
    b>Fatigue is a frequently experienced and patient-relevant complaint in RA. Disease activity, anaemia and pain are regarded as disease-related factors that may lead to fatigue in RA...
  53. ncbi Fatigue in tennis: mechanisms of fatigue and effect on performance
    Daniel J Hornery
    Australian Institute of Sport, Canberra, Australian Capital Territory, Australia
    Sports Med 37:199-212. 2007
    ..science and medical journal databases (SportDiscus and PubMed) that has attempted to quantify the effects of fatigue on tennis performance...
  54. pmc Validation of the fatigue severity scale in a Swiss cohort
    Philipp O Valko
    Department of Neurology, University Hospital of Zurich, Zurich, Switzerland
    Sleep 31:1601-7. 2008
    b>Fatigue is highly prevalent and has a negative impact on quality of life and performance in a variety of disorders...
  55. ncbi Fatigue in cancer patients compared with fatigue in the general United States population
    David Cella
    Center on Outcomes Research and Education CORE, Evanston Northwestern Healthcare and Northwestern University, Illinois 60201, USA
    Cancer 94:528-38. 2002
    Although fatigue is a common symptom among cancer patients, it is also a common experience in the general, healthy population...
  56. ncbi The burden of fatigue and quality of life in myeloproliferative disorders (MPDs): an international Internet-based survey of 1179 MPD patients
    Ruben A Mesa
    Department of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 109:68-76. 2007
    Few objective data exist on the burden of fatigue and other constitutional symptoms in patients with myeloproliferative disorders (MPD).
  57. ncbi Radiotherapy-related fatigue
    Barbara Alicja Jereczek-Fossa
    Department of Radiotherapy, European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy
    Crit Rev Oncol Hematol 41:317-25. 2002
    Radiotherapy-induced fatigue is a common early and chronic side-effect of irradiation, reported in up to 80 and 30% of patients during radiation therapy and at follow-up visits, respectively...
  58. ncbi Psychophysiological investigation of vigilance decrement: boredom or cognitive fatigue?
    Nathalie Pattyn
    Department of Cognitive and Biological Psychology, Vrije Universiteit Brussel, Pleinlaan, 2, 1050 Brussel, Belgium
    Physiol Behav 93:369-78. 2008
    ..There was no physiological difference between the endogenous and exogenous conditions. Subjective experience of participants was more compatible with boredom than with high mental effort...
  59. ncbi Exercise manages fatigue during breast cancer treatment: a randomized controlled trial
    Victoria Mock
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, USA
    Psychooncology 14:464-77. 2005
    b>Fatigue is the most prevalent and debilitating symptom experienced by breast cancer patients receiving adjuvant chemotherapy or radiation therapy and few evidence-based treatments are available to manage this distressing side-effect...
  60. ncbi Fatigue, sleep restriction and driving performance
    Pierre Philip
    Clinique du Sommeil, CHU Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
    Accid Anal Prev 37:473-8. 2005
    ..D.]) drove 1000 km (625 miles) over 10 h during five 105 min sessions on an open highway. Self-rated fatigue and sleepiness before each session, number of inappropriate line crossings from video recordings and simple ..
  61. ncbi Prevalence of chronic disabling fatigue in children and adolescents
    Anne Farmer
    MRC Social, Genetic, Developmental Psychiatric Research Centre, Institute of Psychiatry, London, UK
    Br J Psychiatry 184:477-81. 2004
    ..The epidemiology of chronic fatiguing illnesses in young people is poorly understood...
  62. ncbi Experience of severe fatigue long after stroke and its relation to depressive symptoms and disease characteristics
    S P van der Werf
    The Netherlands Fatigue Research Group, Department of Medical Psychology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Eur Neurol 45:28-33. 2001
    Although the experience of abnormal fatigue is recognised as a major disabling symptom in many chronic neurological diseases, little is known about the persistence of severe fatigue after an abrupt neurological incident like a stroke...
  63. ncbi Heart rate variability reflects self-regulatory strength, effort, and fatigue
    Suzanne C Segerstrom
    Department of Psychology, University of Kentucky, 115 Kastle Hall, Lexington, KY 40506 0044, USA
    Psychol Sci 18:275-81. 2007
    ..HRV appears to index self-regulatory strength and effort, making it possible to study these phenomena in the field as well as the lab...
  64. pmc Impact of medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial
    B Oh
    Department of Medicine, Concord Repatriation General Hospital, University of Sydney, Concord, New South Wales, Australia
    Ann Oncol 21:608-14. 2010
    ..This study aimed to evaluate in a randomized controlled trial, the use of Medical Qigong (MQ) compared with usual care to improve the quality of life (QOL) of cancer patients...
  65. ncbi Relationships among infant sleep patterns, maternal fatigue, and development of depressive symptomatology
    Cindy Lee Dennis
    Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada
    Birth 32:187-93. 2005
    ..The objective of this study was to examine relationships among infant sleep patterns, maternal fatigue, and the development of postpartum depression in women with no major depressive symptomatology at 1 week ..
  66. ncbi Effects of general and local fatigue on postural control: a review
    Thierry Paillard
    Laboratoire Activité Physique, Performance et Santé, EA 4445, Universite de Pau et des Pays de l Adour, Departement STAPS, ZA Bastillac Sud, 65000 Tarbes, France
    Neurosci Biobehav Rev 36:162-76. 2012
    ..are triggered to counteract or limit the disturbance of postural control due to the general and local muscle fatigue. Conceptual models are proposed to explain how the central contribution privileges certain sensory information ..
  67. ncbi Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study
    Knut Arne Wensaas
    Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Gut 61:214-9. 2012
    ..Giardia lamblia is a common cause of gastroenteritis worldwide, but there is limited knowledge about the long-term complications...
  68. ncbi Quality of life in multiple sclerosis: the impact of depression, fatigue and disability
    M P Amato
    Department of Neurology, University of Florence, Italy
    Mult Scler 7:340-4. 2001
    ..Scale), cognitive function (Mini Mental State Examination), depression (Hamilton Rating Scale for Depression) and fatigue (Fatigue Severity Scale)...
  69. pmc Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Rd, 5th Floor, Atlanta, GA 30322, USA
    J Clin Oncol 26:971-82. 2008
    Patients with cancer experience a host of behavioral alterations that include depression, fatigue, sleep disturbances, and cognitive dysfunction...
  70. ncbi Poststroke fatigue: a 2-year follow-up study of stroke patients in Sweden
    Eva Lotta Glader
    Department of Public Health and Clinical Medicine, University Hospital, Umea, Sweden
    Stroke 33:1327-33. 2002
    b>Fatigue is common among stroke patients. This study determined the prevalence of fatigue among long-term survivors after stroke and what impact fatigue had on various aspects of daily life and on survival.
  71. ncbi Fatigue in the general Norwegian population: normative data and associations
    J H Loge
    Department of Behavioural Sciences in Medicine, University of Oslo, Norway
    J Psychosom Res 45:53-65. 1998
    Population norms for interpretation of fatigue measurements have been lacking, and the sociodemographic associations of fatigue are poorly documented. A random sample of 3500 Norwegians, aged 19-80 years, was therefore investigated...
  72. ncbi Postural control in women with multiple sclerosis: effects of task, vision and symptomatic fatigue
    R E A van Emmerik
    Department of Kinesiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Gait Posture 32:608-14. 2010
    ..An additional obstacle facing people with MS is a high incidence of symptomatic fatigue (>70%)...
  73. ncbi Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness
    Michael Maes
    Maes Clinics, Antwerp, Belgium
    Neuro Endocrinol Lett 30:462-9. 2009
    ..Coenzyme Q10 (CoQ10) is a strong antioxidant that has anti-inflammatory effects...
  74. ncbi Psychosocial working conditions and exhaustion in a working population sample of Swedish middle-aged men and women
    Sara I Lindeberg
    Social Medicine and Global Health, Department of Clinical Sciences Malmo, Faculty of Medicine, Lund University, Malmo, Sweden
    Eur J Public Health 21:190-6. 2011
    ..The aim of the present study was to explore associations between chronic stressors, in terms of psychosocial working conditions, and exhaustion in a Swedish middle-aged population sample...
  75. pmc Serum cytokine and glucose levels as predictors of poststroke fatigue in acute ischemic stroke patients
    Heidi Ormstad
    Vestre Viken Hospital Trust, Ringerike, Servicebox 13, 3530 Hønefoss, Norway
    J Neurol 258:670-6. 2011
    b>Fatigue is a common but often overlooked symptom after stroke...
  76. ncbi Fatigue, mood and quality of life improve in MS patients after progressive resistance training
    U Dalgas
    Department of Sport Science, University of Aarhus, Aarhus, Denmark
    Mult Scler 16:480-90. 2010
    b>Fatigue occurs in the majority of multiple sclerosis patients and therapeutic possibilities are few...
  77. ncbi Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters
    P Flachenecker
    Department of Neurology, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Mult Scler 8:523-6. 2002
    b>Fatigue is one of the most common, yet poorly defined, disabling symptoms in patients with multiple sclerosis (MS)...
  78. ncbi Quality of life in brain tumor patients: the relative contributions of depression, fatigue, emotional distress, and existential issues
    Guy Pelletier
    Department of Psychosocial Resources, Tom Baker Cancer Centre, University of Calgary, AB, Canada
    J Neurooncol 57:41-9. 2002
    ..The objectives of this study were: (1) to document the prevalence of depression, fatigue, emotional distress, and existential issues in a sample of brain tumor patients (2) to examine the ..
  79. pmc Selective effect of physical fatigue on motor imagery accuracy
    Franck Di Rienzo
    CRIS EA 647, Performance Mentale, Motrice et du Matériel P3M, Universite Claude Bernard Lyon 1, F 69000 Villeurbanne Cedex, France
    PLoS ONE 7:e47207. 2012
    ..during actual training sessions is usually recommended, experimental studies examining the effect of physical fatigue on subsequent motor imagery performance are sparse and yielded divergent findings...
  80. ncbi The PedsQL in pediatric cancer: reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module
    James W Varni
    Center for Child Health Outcomes, Children s Hospital and Health Center, 3020 Children s Way, San Diego, CA 92123, USA
    Cancer 94:2090-106. 2002
    ..The PedsQL Multidimensional Fatigue Scale was designed to measure fatigue in pediatric patients. The PedsQL 3...
  81. ncbi Exercise barriers and preferences among women and men with multiple sclerosis
    Miho Asano
    School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Disabil Rehabil 35:353-61. 2013
    ..The secondary objective was to estimate the extent to which women and men with MS present different perceived-health, depressive symptoms, and current exercise routines or preferences...
  82. ncbi Visual cortex: Fatigue and adaptation
    M Carandini
    Swiss Federal Institute of Technology and University of Zurich, Switzerland
    Curr Biol 10:R605-7. 2000
    ..Recent results demonstrate that this visual adaptation is explained partly by a cellular mechanism acting in individual cortical neurons...
  83. ncbi A controlled investigation into the psychological determinants of fatigue
    Ashley Craig
    Department of Health Sciences, University of Technology, P O Box 123 Broadway, Sydney, NSW 2007, Australia
    Biol Psychol 72:78-87. 2006
    Driver fatigue is associated with risks of road accidents that result in injury and death...
  84. ncbi Post-stroke fatigue and return to work: a 2-year follow-up
    G Andersen
    Department of Neurology, Aarhus University Hospital, Denmark
    Acta Neurol Scand 125:248-53. 2012
    Post-stroke fatigue may affect the ability to return to work but quantitative studies are lacking.
  85. ncbi Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development
    Amy E Latimer-Cheung
    School of Kinesiology and Health Studies, Queen s University, Kingston, Ontario, Canada
    Arch Phys Med Rehabil 94:1800-1828.e3. 2013
    To conduct a systematic review of evidence surrounding the effects of exercise training on physical fitness, mobility, fatigue, and health-related quality of life in adults with multiple sclerosis (MS).
  86. ncbi Effect of abiraterone acetate on fatigue in patients with metastatic castration-resistant prostate cancer after docetaxel chemotherapy
    C N Sternberg
    Department of Medical Oncology, San Camillo and Forlanini Hospitals, Rome, Italy
    Ann Oncol 24:1017-25. 2013
    b>Fatigue is a common, debilitating side-effect of prostate cancer and its treatment...
  87. ncbi The correlation between fatigue, physical function, the systemic inflammatory response, and psychological distress in patients with advanced lung cancer
    Duncan J F Brown
    St Columba s Hospice, Edinburgh, United Kingdom
    Cancer 103:377-82. 2005
    ..disability is reported frequently in fatigued cancer patients, but little is known about the correlation between fatigue and objective physical function...
  88. ncbi Clinical neurophysiology of fatigue
    M J Zwarts
    University Medical Centre Nijmegen, Institute of Neurology, 920 Department of Clinical Neurophysiology, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Clin Neurophysiol 119:2-10. 2008
    b>Fatigue is a multidimensional concept covering both physiological and psychological aspects...
  89. ncbi Correlation of self-assessed fatigue and alertness in multiple sclerosis
    Nicholetta Weinges-Evers
    NeuroCure Clinical Research Center, Charite University Medicine Berlin, Germany
    Mult Scler 16:1134-40. 2010
    b>Fatigue is the most common symptom in multiple sclerosis patients, but is difficult to measure; quantification thus relies on self-assessed questionnaires.
  90. ncbi Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids
    Julienne E Bower
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience at UCLA, 300 UCLA Medical Plaza, Room 3306, Box 957076 Los Angeles, CA 90095 7076, USA
    Brain Behav Immun 21:251-8. 2007
    b>Fatigue is a common problem following cancer treatment and our previous studies suggest that a chronic inflammatory process might contribute to cancer-related fatigue...
  91. ncbi Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study
    A M Malagoni
    Vascular Diseases Center, University of Ferrara, Ferrara, Italy
    Int Angiol 29:176-82. 2010
    Chronic fatigue (CF) severely affects patients with multiple sclerosis (MS), but its pathogenesis remains elusive and the effectiveness of available treatments is modest...
  92. ncbi The impact of junior doctors' worktime arrangements on their fatigue and well-being
    Philip Tucker
    Department of Psychology, Swansea University, Swansea, United Kingdom
    Scand J Work Environ Health 36:458-65. 2010
    ..We compared groups of junior doctors working on different schedules in order to identify which features of schedule design most negatively affected their fatigue and well-being in recent weeks.
  93. pmc Management of axitinib (AG-013736)-induced fatigue and thyroid dysfunction, and predictive biomarkers of axitinib exposure: results from phase I studies in Japanese patients
    Yutaka Fujiwara
    Medical Oncology Hematology, Department of Medicine, Kobe University Hospital, 7 5 2, Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Invest New Drugs 30:1055-64. 2012
    ..We report on data obtained from 18 Japanese patients with advanced solid tumors in two phase I trials that evaluated the safety, pharmacokinetics and antitumor activity of axitinib and also examined potential biomarkers...
  94. ncbi Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis
    B Wood
    Menzies Research Institute Tasmania, University of Tasmania, Tasmania, Australia
    Mult Scler 19:217-24. 2013
    Anxiety, depression and fatigue are commonly reported by persons with multiple sclerosis (PwMS).
  95. ncbi Basal ganglia and frontal/parietal cortical atrophy is associated with fatigue in relapsing-remitting multiple sclerosis
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Italy
    Mult Scler 16:1220-8. 2010
    b>Fatigue is one of the most frequent symptoms suffered by patients affected by multiple sclerosis. The patho-physiological basis of multiple sclerosis-related fatigue remains to be elucidated.
  96. ncbi Body composition, physical fitness, functional performance, quality of life, and fatigue benefits of exercise for prostate cancer patients: a systematic review
    Justin W L Keogh
    Bond University, Gold Coast, Queensland, Australia
    J Pain Symptom Manage 43:96-110. 2012
    ..Because ADT acts by means of reducing testosterone production, exercise may offset many of the ADT side effects and those of the cancer itself...
  97. ncbi Supraspinal regulation of physical fatigue
    Masaaki Tanaka
    Department of Physiology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Neurosci Biobehav Rev 36:727-34. 2012
    b>Fatigue, defined as difficulty in initiating or sustaining voluntary activities, can be classified as physical or mental, and physical fatigue can be classified as peripheral or central (spinal or supraspinal)...
  98. ncbi "Functional" or "psychosomatic" symptoms, e.g. a flu-like malaise, aches and pain and fatigue, are major features of major and in particular of melancholic depression
    Michael Maes
    Maes Clinics, Antwerp, Belgium
    Neuro Endocrinol Lett 30:564-73. 2009
    ..There is a strong comorbidity and a biological similarity between major depression and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
  99. pmc Exertion fatigue and chronic fatigue are two distinct constructs in people post-stroke
    Benjamin Y Tseng
    Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, Kansas, USA
    Stroke 41:2908-12. 2010
    Post-stroke fatigue is a common and neglected issue despite the fact that it impacts daily functions, quality of life, and has been linked with a higher mortality rate because of its association with a sedentary lifestyle...
  100. pmc I'm so tired: biological and genetic mechanisms of cancer-related fatigue
    Andrea Barsevick
    Cancer Prevention and Control Program, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA, USA
    Qual Life Res 19:1419-27. 2010
    The goal of this paper is to discuss cancer-related fatigue (CRF) and address issues related to the investigation into potential biological and genetic causal mechanisms...
  101. ncbi Psychometric properties of the Fatigue Severity Scale: Rasch analyses of responses in a Norwegian and a Swedish MS cohort
    A Lerdal
    Department of Health Sciences, Buskerud University College, Drammen, Norway
    Mult Scler 16:733-41. 2010
    Rigorous testing of the original Fatigue Severity Scale (FSS-9) with modern psychometric methods is warranted.

Research Grants80

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic Fatigue Syndrome (CFS) is a complex disease with a prevalence as high as 1%...
  3. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    ..for behavioral symptoms of posttraumatic stress disorder (PTSD) and chronic postconcussive syndrome, including fatigue, anxiety, depression, irritability, insomnia, and decreased quality of life (QoL), as well as changes in body ..
  4. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..that determine contraction and relaxation-;seconds to minutes -when sustained activity may lead to myogenic fatigue- and hours to weeks -patterns that cause changes in gene expression and long-term adaptation-...
  5. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..In most cases, overactive bladder symptoms are associated with insomnia, anxiety, fatigue, and even depression...
  6. Role of CD44 in experimental Multiple Sclerosis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..of symptoms among recent Gulf war and other war veterans which include cognitive dysfunction, depression, chronic fatigue, musculoskeletal complaints, post-traumatic stress disorder and respiratory illness...
  7. Respiratory and autonomic plasticity following intermittent hypoxia
    JASON HAROLD MATEIKA; Fiscal Year: 2012
    ..Consequences of untreated sleep apnea include increased daytime fatigue, hypertension and stroke. Thus, sleep apnea is a major health concern...
  8. Role of beta-endorphin in cancer therapy induced fatigue
    David E Fisher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fatigue occurs in up to 80% of cancer patients undergoing radiation or chemotherapy and is significantly debilitating. Our lab studies skin signaling which mediates UV induced pigmentation...
  9. Evaluation of obstructive sleep apnea with long range 3D endoscopic FDOCT
    Jun Zhang; Fiscal Year: 2013
    ..Patients with OSA suffer from fragmented sleep, chronic fatigue, daytime sleepiness, lack of concentration and memory problems with consequences including increased risk of ..
  10. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..with major depression including 1) prominent neurovegetative symptoms such as psychomotor retardation and fatigue;2) flattening of the diurnal cortisol curve;and 3) increased plasma and cerebrospinal fluid (CSF) concentrations ..
  11. Vascular and Skeletal Muscle Function in Gulf War Veterans Illness
    Scott Kinlay; Fiscal Year: 2013
    ..illness (CMI) criteria, which are based on statistical symptom cluster analysis resulting in three categories: fatigue, mood/ cognition, and musculoskeletal symptoms...
  12. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..has been used extensively by physicians over several decades to treat inflammatory disorders including chronic fatigue syndrome, rheumatoid arthritis, asthma, neurological diseases and eczema, with little understanding as to why B12 ..
  13. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2012
    ..in decreased slow TnT protein, muscle atrophy and a switch to fast fiber phenotypes with decreased tolerance to fatigue. We shall also study the phenotype of a mouse model in which the ANM nonsense mutation is knocked in the slow TnT ..
  14. Addressing Psychosocial Disparities in Rural Hispanic Cancer Survivors
    Rachel M Ceballos; Fiscal Year: 2013
    ..Cancer survivors can experience distress from long-term medical (i.e., fatigue), financial (i.e., job loss), and socio-emotional (i.e...
  15. Novel treatment of menopausal hot flushes with an estradiol prodrug
    Laszlo Prokai; Fiscal Year: 2012
    ..negatively impact the quality of life of women because they are associated with sleep disturbances resulting in fatigue, depression, irritability, and forgetfulness, as well as acute physical discomfort and negative effects on work...
  16. Prevalence and Impact of Frailty among Dialysis Patients
    Kirsten L Johansen; Fiscal Year: 2013
    ..data needed for us to define a frailty phenotype based on low physical activity, poor physical functioning, and fatigue/exhaustion...
  17. Sterile Hepatic Inflammation
    Wajahat Zafar Mehal; Fiscal Year: 2012
    ..This results in a very high degree of morbidity due to fatigue, jaundice, ankle swelling and pruritis...
  18. Abdominal Symptom Phenotypes: Pathways to New Biomarkers
    Robert Shulman; Fiscal Year: 2010
    ..well-recognized associations between IBS and other conditions (fibromyalgia, headache) and symptoms (depression, fatigue, insomnia)...
  19. Effects of nerve demyelination on auditory synaptic functions
    Jun Hee Kim; Fiscal Year: 2012
    ..mutations or autoimmune disease, as in the case of multiple sclerosis (MS) can result in increased motor neurons fatigue and nerve impulse conduction failure...
  20. Dysfunctional PGC-1alpha expression in skeletal muscle during diabetes
    S Russ Price; Fiscal Year: 2013
    ..muscle atrophy is a frequent co-morbidity of diabetes mellitus (DM) and other chronic diseases that causes fatigue and weakness. Loss of muscle mass also is a risk factor for mortality in these conditions...
  21. Underserved Men's Understanding of Androgen Deprivation Therapy Related Risks
    Sally L Maliski; Fiscal Year: 2012
    ..to prostate cancer, studies have shown that men on ADT are at increased risk for vasomotor symptoms, depression, fatigue, diminished health-related quality of life (HRQOL), decreased bone mineral density (BMD), sexual dysfunction, ..
  22. Planning a Multicenter Trial of PDE5A Inhibition for Duchenne Muscular Dystrophy
    Ronald G Victor; Fiscal Year: 2012
    ..target of NO in vascular smooth muscle-rapidly ameliorated exercise-induced muscle ischemia, muscle injury, and fatigue in the mdx mouse model of DMD...
  23. Mechanisms and consequences of sleep disordered breathing in COPD
    Cynthia D Brown; Fiscal Year: 2012
    ..sleep fragmentation and gas exchange abnormalities are common in COPD with consequent complaints of daytime fatigue. Preliminary data suggest that individuals with COPD are unable to compensate for small degrees of inspiratory ..
  24. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..associated with marked behavioral changes consistent with decreased DA function including depression, anhedonia, fatigue, motor slowing, impaired sleep and cognitive dysfunction...
  25. Coping Skills Training in Heart Failure: Outcomes and Mechanisms
    Andrew Sherwood; Fiscal Year: 2013
    ..HF symptoms, including dyspnea and fatigue, are a major source of distress for patients with HF, and often impose severe limitations on their daily ..
  26. Freeze-Dried Blueberries: Prevention and Rehabilitation Strategies in MS
    Susan O McGuire; Fiscal Year: 2011
    ..of proinflammatory cytokines, thought to be responsible for some of the sickness behavior, such as depression, fatigue and cognitive dysfunction, in MS...
  27. Study of Energy and Aging
    Steven Cummings; Fiscal Year: 2009
    ..Loss of mobility characterized by slowing gait speed, exertional fatigue and exhaustion is a hallmark of age-related functional decline...
  28. Nutrition Intervention to Reduce Symptoms in Patients with Advanced Heart Failure
    Terry A Lennie; Fiscal Year: 2013
    ..1) to determine the effects of a 6-month nutrition intervention on symptom burden (edema, shortness of air, and fatigue) and health related quality of life at 3 and 6 months, and time to heart failure rehospitalization or all-cause ..
    Kathleen C Light; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic fatigue syndrome (CFS) is a complex multisymptom disorder that lacks objective blood-based biomarkers to use in diagnosis or clinical management of symptoms...
  30. CRCNS: Computation-Enabled Adaptive Ventilatory Control System
    Ranu Jung; Fiscal Year: 2013
    ..the need for manual stimulation parameter tuning, and inability to alter stimulation parameters on muscle fatigue or changing metabolic demand...
  31. Central Nervous System Mechanisms in Knee Osteoarthritis (KOA)
    Daniel J Clauw; Fiscal Year: 2013
    ..g., fatigue, sleep problems) to be commonly present in OA 13, 14...
  32. Reducing Breast Cancer Recurrence with Weight Loss: A Vanguard Trial
    Cheryl L Rock; Fiscal Year: 2013
    ..To assess the impact of the intervention on quality of life (QOL), particularly physical functioning and fatigue;and (4) To prospectively collect blood and DNA samples to enable analysis of potential mechanisms and ..
  33. Unconventional Synaptic Modulation at the Vertebrate Neuromuscular Junction
    Clark A Lindgren; Fiscal Year: 2010
    ..In fact, disruption of NO synthesis at the NMJs of humans with muscular dystrophy may contribute to fatigue. The second question will use a fluorescence-based technique for measuring NO to determine whether the muscle is ..
  34. Long-acting EPO analog for treating anemia associated with chronic kidney disease
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Anemia leads to fatigue, a decreased quality of life and correlates with increased mortality in CKD patients...
  35. Cellular Mechanisms for the hormonal Modulation of Sleep
    Jessica Mong; Fiscal Year: 2009
    ..Complaints by women of insomnia, disturbed sleep, difficulty returning to sleep and fatigue rise sharply during their menopausal years when estrogen levels decrease markedly...
  36. Diagnostic Utility of mtDNA Content and Exercise Challenge in Veterans with GWI
    MICHAEL JOSEPH FALVO; Fiscal Year: 2013
    ..GWI symptoms vary from fatigue and pain to cognitive dysfunction and sleep disturbances, but have been difficult to quantify and treat sometimes ..
  37. Research and Mentoring on Energetic Factors and Cancer: Established Investigator
    Leslie Bernstein; Fiscal Year: 2013
    ..endometrial cancer survivors to study how changes in physical activity and body weight affect survival and how these lifestyle practices are associated with diet, use of complementary medicines, fatigue, depression, and quality of life.
  38. Caring for Those Who Share: Mitigating Iron Deficiency in Regular Blood Donors
    Alan E Mast; Fiscal Year: 2013
    ..the realization that iron deficiency even in the absence of anemia is associated with adverse effects including fatigue and decreased exercise tolerance, as well as neurological symptoms such as decreased cognitive function, pica and ..
  39. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2013
    ABSTRACT In patients with chronic heart failure (CHF) difficulty to breathe, and premature fatigue are the main symptoms limiting the patient's exercise tolerance, and ability to perform activities of daily life...
  40. Sestrin1-knockout mice as a model of facilitated muscle aging
    Jun Hee Lee; Fiscal Year: 2013
    ..of dSesn in aged flies enhances intramuscular autophagy, prevents age-dependent mobility decline and increases fatigue tolerance...
    William E Armstrong; Fiscal Year: 2011
    ..discharge pattern that maximizes hormone release per spike (referred to as facilitation) and avoids secretory fatigue (when release abates during continued activity)...
  42. Enhancing neutrophil function in neutropenia-related pneumonia
    Hongbo R Luo; Fiscal Year: 2012
    ..to antibiotic treatment and G-CSF therapy is often associated with side-effects such as bone pain, headache, fatigue, nausea, and higher risk of getting leukemia...
  43. Cytokine Effects on Amphetamine-Induced Dopamine Release using PET Neuroimaging
    Jennifer C Felger; Fiscal Year: 2011
    ..IFN)-alpha, is associated with behavioral changes consistent with DA depletion including depressive behavior, fatigue, and reduced locomotor activity...
  44. VEGF and Skeletal Muscle Adaptation during Chronic Overload
    KIMBERLY ANN HUEY; Fiscal Year: 2011
    ..Skeletal muscle normally responds to chronic elevations in load and activity by increasing mass, strength, and/or fatigue resistance...
  45. MBSR Symptom Cluster Trial for Breast Cancer Survivors
    Cecile A Lengacher; Fiscal Year: 2013
    ..After treatment completion, breast cancer survivors frequently experience residual symptoms including pain, fatigue, sleep dysfunction, anxiety, depression, and fear of recurrence...
  46. Antimicrobial and Regenerative Treatment for Oral Mucositis
    SHENDA BAKER; Fiscal Year: 2012
    ..In addition, mucositis can lead to systemic toxicities and is associated with symptom complexes that include fatigue, and mood change...
  47. Mechanisms of Cancer Treatment Related Symptoms
    Lisa J Wood; Fiscal Year: 2013
    ..These symptoms can greatly influence the subjective sensation of cancer treatment related fatigue (CTRF) which is the most common and distressing CTRS, and one that has a profoundly negative effect on physical ..
  48. ERalpha and the metabolic syndrome
    Andrea L Hevener; Fiscal Year: 2013
    ..Indeed our findings show accelerated muscle fatigue and impaired exercise-mediated induction of factors controlling mitochondrial turnover in muscle-specific ER1 ..
  49. Can Lifestyle Modify Fatigue in Breast Cancer Survivors?
    Wendy Y Chen; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): ABSTRACT Fatigue is the most common and distressing symptom among breast cancer survivors and can persist for years after treatment, even in those clinically disease-free...
  50. Hereditary Multiple Exostosis Syndrome: Pathogenesis and Treatment
    MAURIZIO contact PACIFICI; Fiscal Year: 2010
    ..Current therapies are palliative, and patients struggle with pain, limited mobility and fatigue and undergo multiple surgeries throughout their lives...
  51. Inflammation, Stress, and Social Behavior: Using Ecological Assessments and Model
    Charles Raison; Fiscal Year: 2012
    ..regimen of chronic cytokine exposure known to produce profound behavioral disturbances, including depression, fatigue and sickness, in a high percentage of individuals...
    Paul J May; Fiscal Year: 2012
    ..MIFs are highly fatigue resistant and tonically active...
  53. Acupressure for Persistent Cancer Related Fatigue
    Suzanna M Zick; Fiscal Year: 2013
    ..Persistent cancer-related fatigue (PCRF), a state of being tired or weary, is one of the most common and distressing symptoms experienced by breast ..
  54. A Mouse model of Barth syndrome, a mitochondrial cardiolipin disorder
    Zaza Khuchua; Fiscal Year: 2013
    ..by mutations in the tafazzin (taz) gene and characterized by dilated cardiomyopathy, skeletal myopathy, chronic fatigue, exercise intolerance, cyclic neutropenia and organic aciduria...
  55. Cardiovascular and Prostatic Safety of Testosterone Therapy in Aging Males
    Stephen K Van Den Eeden; Fiscal Year: 2013
    ..diagnosis of androgen deficiency is made when clinical symptoms such as decreased libido, erectile dysfunction, fatigue and depression are found in conjunction with low levels of serum testosterone...
  56. Specificity and Validity of Oxidative Stress Model of Chronic Fatigue Syndrome
    Dikoma C Shungu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic fatigue syndrome (CFS) is a complex multi-system disorder, which is often misdiagnosed as a psychiatric illness. As a result, the diagnosis of CFS is highly controversial...
  57. Telephone-based coping skills training for COPD
    James A Blumenthal; Fiscal Year: 2012
    ..COPD is an obstructive airway disease marked by symptoms of dyspnea, paroxysmal coughing, pain, fatigue, and insomnia. Approximately 12...
  58. Phase 1 of AR-42 in relapsed CLL, lymphoma, myeloma
    Craig C Hofmeister; Fiscal Year: 2012
    ..serum levels and unconfirmed responses have been observed in myeloma patients as a single agent without the fatigue and nausea characteristic of other class I/II DAC inhibitors...
  59. Psychosexual Intervention for Gynecologic Cancer Patients
    Barbara L Andersen; Fiscal Year: 2012
    ..Secondary outcomes include emotional distress, depressive symptoms, and fatigue. Important for later dissemination, procedures are in place to collect cost-effectiveness data...
  60. Muscle Afferent Feedback Effects in Patients with Heart Failure
    Markus Amann; Fiscal Year: 2013
    ..Cardinal determinants of these characteristics include excessive exercise pressor reflex, premature fatigue, and exertional dyspnea...
  61. Analysis of the Coxiella burnetii Type IV Secretion System During Infection
    Edward I Shaw; Fiscal Year: 2012
    ..It is the etiologic agent of acute Q fever and chronic diseases such as endocarditis, hepatitis, and chronic fatigue. Acquired by inhalation, C...
  62. Bupropion for Depression in ESRD Patients on Hemodialysis
    Pedro L Delgado; Fiscal Year: 2013
    ..also has been found to be effective in treating attention deficit disorder and in improving cognitive and fatigue in MDD patients...
  63. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Chronic fatigue syndrome (CFS) is characterized by fatigue, malaise, sleep and autonomic disturbances; it is considered a neuroimmune disorder with dysregulation of the hypothalamic-..
  64. Mechanisms of Respiratory Muscle Dysfunction in Heart Failure
    LEONARDO FERREIRA; Fiscal Year: 2010
    ..provided by applicant): In patients with chronic heart failure (CHF) difficulty to breathe, and premature fatigue are the main symptoms limiting the patient's exercise tolerance, and ability to perform activities of daily ..
  65. Electrical Stimulation for Hemiplegic Shoulder Pain
    John Chae; Fiscal Year: 2010
    ..ES is delivered at a relatively high frequency between 20 and 35 Hz, which can lead to more rapid onset of muscle fatigue.7 Third, due to stimulation-induced pain and muscle fatigue, an escalating stimulation schedule is needed...
  66. Changes in Control of Movement Timing and Stability With Muscle Fatigue
    JONATHAN DINGWELL; Fiscal Year: 2009
    ..Work-related musculoskeletal injuries have been linked to movement repetition, improper postures, and muscle fatigue. Muscle fatigue and/or the muscle imbalances that result from fatigue may be important as direct causes and/or ..
    Andrew Karduna; Fiscal Year: 2001
    ..There is evidence that repetitive motion is associated with muscle fatigue and abnormal shoulder motion, which in turn may lead to damage of the rotator cuff musculature...
    Cesar Blanco; Fiscal Year: 2002
    ..Pharmacologic AAS treatment is effective in decreasing diaphragm (DIA) fatigue during direct muscle stimulation in female rats...
  69. "Strength training, Self-efficacy, and Function in Blacks with Prostate Cancer."
    Bernard Hurley; Fiscal Year: 2009
    ..growth of existing tumors, the associated suppression of testosterone leads to muscle atrophy, loss of strength, fatigue, bone loss, increased fat deposition, and functional declines that lead to a deterioration in quality of life...
    Andrew Avins; Fiscal Year: 2004
    ..proposed project is a randomized pilot trial of a Swedish-style massage therapy intervention for the treatment of fatigue in patients who are undergoing cancer chemotherapy...
  71. Stress and Neuroimmune Dysergulation in Chronic Fatigue Patients
    Kathleen Light; Fiscal Year: 2007
    ..proposing novel translational investigations into neuroimmune and sensory dysregulation in patients with Chronic Fatigue Syndrome (CFS), to be performed in parallel with guiding animal model research also directed by our research ..
  72. Analysis of the Cytokine-Immunological Model of a Cancer-Related Symptom Cluster
    Jennifer Steel; Fiscal Year: 2009
    ..In a recent NIH State-of-the-Science Statement, pain, fatigue, and depression were recently reported to be the most common and distressing symptoms of cancer...
    David Prezant; Fiscal Year: 2001
    ..abstract): Long-term goal: In patients with chronic obstructive pulmonary diseases (COPD), respiratory muscle fatigue resistance must be increased to maintain ventilation in the face of chronic respiratory resistive loading (CRRL)...
    GERALDINE NEUBERGER; Fiscal Year: 1999
    DESCRIPTION: (Adapted from investigator's abstract) Fatigue, pain, and depression are hallmark symptoms of rheumatoid arthritis (RA) that if unrelieved lead to poor quality of life and functional decline...
  75. Are Fibromyalgia and Chiari I Malformation Related?
    Dedra Buchwald; Fiscal Year: 2005
    ..FM) is a common condition of unknown etiology characterized by widespread muscle pain, sleep disturbances, fatigue, and various subjective neurological complaints...
  76. Fatigue After Myocardial Infarction in Older Adults
    Patricia Crane; Fiscal Year: 2005
    ..One frequently reported barrier to participation in physical activity is fatigue. Little work, however, has been done on fatigue after Ml...
  77. Mechanical System for Low Force Fatigue Tissue Testing
    Dawn M Elliott; Fiscal Year: 2010
    ..The ElectroPulse E3000 is a state-of-the art research system for fatigue testing. The test speed range from 1mm/min to 1...
    Rolf Hubmayr; Fiscal Year: 1992
    ..a) hypercarbic respiratory failure during weaning from mechanical ventilation usually results from diaphragm fatigue, and b) diaphragm fatigue results from an imbalance between the mechanical load on the respiratory muscles and ..
    JOHN MINOTTI; Fiscal Year: 1993
    b>Fatigue and exercise intolerance are major symptoms of congestive heart failure (CHF), yet indices of cardiac function correlate poorly with exercise capacity, suggesting an important contribution of peripheral abnormalities...
    Anthony Komaroff; Fiscal Year: 1991
    This study addresses the following question: how prevalent is "chronic fatigue syndrome", or CFS, -- sometimes called "chronic mononucleosis" or "chronic Epstein-Barr virus (EBV) infection" -- and other causes of chronic fatigue, in the ..