edema

Summary

Summary: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Top Publications

  1. ncbi Mast cell degranulation induced by two phospholipase A2 homologues: dissociation between enzymatic and biological activities
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas SP, Brazil
    Eur J Pharmacol 343:257-63. 1998
  2. pmc Activation of P2X7 promotes cerebral edema and neurological injury after traumatic brain injury in mice
    Donald E Kimbler
    Department of Neurosurgery, Georgia Health Sciences University, Augusta, Georgia, United States of America
    PLoS ONE 7:e41229. 2012
  3. ncbi Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis
    Fiona M McQueen
    Auckland District Health Board and Auckland University, Auckland, New Zealand
    Arthritis Rheum 48:1814-27. 2003
  4. doi Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study
    Hassan Abdel-Aty
    Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
    J Am Coll Cardiol 53:1194-201. 2009
  5. doi Neurotoxic, myotoxic and cytolytic activities of the new basic PLA(2) isoforms BmjeTX-I and BmjeTX-II isolated from the Bothrops marajoensis (Marajó Lancehead) snake venom
    L A Ponce-Soto
    Department of Biochemistry, Institute of Biology IB, State University of Campinas UNICAMP, P O Box 6109, Zip Code 13083 970, Campinas, SP, Brazil
    Protein J 29:103-13. 2010
  6. doi Protective effects of radon inhalation on carrageenan-induced inflammatory paw edema in mice
    Takahiro Kataoka
    Graduate School of Health Sciences, Okayama University, 5 1 Shikata cho 2 chome, Kita ku, Okayama Shi, Okayama 700 8558, Japan
    Inflammation 35:713-22. 2012
  7. pmc Topography of diabetic macular edema with optical coherence tomography
    M R Hee
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, USA
    Ophthalmology 105:360-70. 1998
  8. ncbi Inflammatory oedema induced by the lys-49 phospholipase A(2) homologue piratoxin-i in the rat and rabbit. Effect of polyanions and p-bromophenacyl bromide
    E C Landucci
    Department of Pharmacology, UNICAMP, 13081 970, Campinas, SP, Brazil
    Biochem Pharmacol 59:1289-94. 2000
  9. doi ACUT2E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heart
    Anthony H Aletras
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Magn Reson Med 59:229-35. 2008
  10. doi Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction
    Franck Thuny
    CREATIS, CNRS UMR 5220, INSERM U1044, Universite de Lyon, Lyon, France
    J Am Coll Cardiol 59:2175-81. 2012

Detail Information

Publications456 found, 100 shown here

  1. ncbi Mast cell degranulation induced by two phospholipase A2 homologues: dissociation between enzymatic and biological activities
    E C Landucci
    Department of Pharmacology, Faculty of Medical Sciences, UNICAMP, Campinas SP, Brazil
    Eur J Pharmacol 343:257-63. 1998
    ..Our results also indicate that p-bromophenacyl bromide may not be a suitable pharmacological tool to investigate the correlation between enzymatic activity and the inflammatory effects of phospholipases A2...
  2. pmc Activation of P2X7 promotes cerebral edema and neurological injury after traumatic brain injury in mice
    Donald E Kimbler
    Department of Neurosurgery, Georgia Health Sciences University, Augusta, Georgia, United States of America
    PLoS ONE 7:e41229. 2012
    Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Cerebral edema, the abnormal accumulation of fluid within the brain parenchyma, contributes to elevated intracranial pressure (ICP) and is a common life-..
  3. ncbi Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis
    Fiona M McQueen
    Auckland District Health Board and Auckland University, Auckland, New Zealand
    Arthritis Rheum 48:1814-27. 2003
    ..imaging (MRI) is capable of revealing synovitis and tendinitis in early rheumatoid arthritis (RA), as well as bone edema and erosion. These features are visible before radiographic joint damage occurs...
  4. doi Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study
    Hassan Abdel-Aty
    Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada
    J Am Coll Cardiol 53:1194-201. 2009
    This study was designed to determine whether imaging myocardial edema would identify acute myocardial ischemia before irreversible injury takes place.
  5. doi Neurotoxic, myotoxic and cytolytic activities of the new basic PLA(2) isoforms BmjeTX-I and BmjeTX-II isolated from the Bothrops marajoensis (Marajó Lancehead) snake venom
    L A Ponce-Soto
    Department of Biochemistry, Institute of Biology IB, State University of Campinas UNICAMP, P O Box 6109, Zip Code 13083 970, Campinas, SP, Brazil
    Protein J 29:103-13. 2010
    ..Both isoforms BmjeTX-I and BmjeTX-II of PLA(2) also induced moderate marked paw edema, evidencing the local increase in vascular permeability...
  6. doi Protective effects of radon inhalation on carrageenan-induced inflammatory paw edema in mice
    Takahiro Kataoka
    Graduate School of Health Sciences, Okayama University, 5 1 Shikata cho 2 chome, Kita ku, Okayama Shi, Okayama 700 8558, Japan
    Inflammation 35:713-22. 2012
    ..Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum...
  7. pmc Topography of diabetic macular edema with optical coherence tomography
    M R Hee
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, USA
    Ophthalmology 105:360-70. 1998
    ..coherence tomography was a useful technique for quantifying macular thickness in patients with diabetic macular edema. The topographic mapping protocol provided geographic information on macular thickness that was intuitive and ..
  8. ncbi Inflammatory oedema induced by the lys-49 phospholipase A(2) homologue piratoxin-i in the rat and rabbit. Effect of polyanions and p-bromophenacyl bromide
    E C Landucci
    Department of Pharmacology, UNICAMP, 13081 970, Campinas, SP, Brazil
    Biochem Pharmacol 59:1289-94. 2000
    ..Our results are consistent with the suggestion that the cationic charge of PrTX-I plays a major role in the inflammatory responses induced by this PLA(2) homologue...
  9. doi ACUT2E TSE-SSFP: a hybrid method for T2-weighted imaging of edema in the heart
    Anthony H Aletras
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health DHHS, 10 Center Drive, Bethesda, MD 20892, USA
    Magn Reson Med 59:229-35. 2008
    ..Imperfect blood suppression, present in all animals on some TSE images, was a problem eliminated by TSE-SSFP and T2-prepared SSFP...
  10. doi Post-conditioning reduces infarct size and edema in patients with ST-segment elevation myocardial infarction
    Franck Thuny
    CREATIS, CNRS UMR 5220, INSERM U1044, Universite de Lyon, Lyon, France
    J Am Coll Cardiol 59:2175-81. 2012
    This study aimed to determine whether post-conditioning at the time of percutaneous coronary intervention could reduce reperfusion-induced myocardial edema in patients with acute ST-segment elevation myocardial infarction (STEMI).
  11. pmc Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells
    Shivalingappa K Swamynathan
    Laboratory of Molecular and Developmental Biology, National Eye Institute NIH, 7 Memorial Drive, Room 129, Bethesda, MD 20892, USA
    Mol Cell Biol 27:182-94. 2007
    ..and aquaporin-5 genes was downregulated, consistent with the Klf4CN corneal epithelial fragility and stromal edema, respectively...
  12. doi Effect of renin-angiotensin system blockade on calcium channel blocker-associated peripheral edema
    Harikrishna Makani
    St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10019, USA
    Am J Med 124:128-35. 2011
    Peripheral edema is a common adverse effect of calcium channel blockers...
  13. doi New insights of dimethyl sulphoxide effects (DMSO) on experimental in vivo models of nociception and inflammation
    Mariantonella Colucci
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Pharmacol Res 57:419-25. 2008
    ..Oral administration of DMSO produced anti-inflammatory effects on zymosan-induced edema in the mouse paw, whereas local administration potentiated the inflammatory action exerted by zymosan...
  14. doi Pharmacological study of edema and myonecrosis in mice induced by venom of the bushmaster snake (Lachesis muta muta) and its basic Asp49 phospholipase A(2) (LmTX-I)
    Daniela C S Damico
    Department of Biochemistry, Institute of Biology, State University of Campinas UNICAMP, P O Box 6109, CEP 13083 970 Campinas, SP, Brazil
    Protein J 27:384-91. 2008
    ..Pre-treatment of the venom with EDTA (5 mM) significantly inhibited the edema and hemorrhage. Histological examination showed that L...
  15. doi Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)
    Candida Aparecida Leite Kassuya
    Department of Pharmacology, Universidade Federal do Parana, Curitiba, PR, Brazil
    J Ethnopharmacol 124:369-76. 2009
    ..This study investigated the antipyretic and anti-inflammatory effects of the ethanolic extract (EEMO), dichloromethane fraction (DCM), and the isolated compound costunolide...
  16. doi Licorice induced hypokalemia, edema, and thrombocytopenia
    M M Celik
    Department of Internal Medicine, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey
    Hum Exp Toxicol 31:1295-8. 2012
    ..In this case report, an association of hypokalemia, edema, and thrombocytopenia that is developed due to the excessive intake of licorice is presented...
  17. pmc Short report: A calcified Taenia solium granuloma associated with recurrent perilesional edema causing refractory seizures: histopathological features
    Winnie W Ooi
    Department of Infectious Diseases, Lahey Clinic, Burlington, Massachusetts, USA
    Am J Trop Med Hyg 85:460-3. 2011
    ..calcified Taenia solium granuloma from a patient who developed recurrent seizures associated with perilesional edema surrounding a calcified cysticercus (PEC)...
  18. doi The alpha11beta1 integrin has a mechanistic role in control of interstitial fluid pressure and edema formation in inflammation
    Ø S Svendsen
    Department of Anesthesia and Intensive Care, Haukeland University Hospital, Department of Biomedicine, University of Bergen, Bergen, Norway
    Arterioscler Thromb Vasc Biol 29:1864-70. 2009
    ..Our aim was to explore whether the newly discovered collagen binding alpha11beta1 integrin has a mechanistic role in inflammatory edema formation.
  19. pmc Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy
    Hanne B Albert
    Research Department, Spine Centre of Southern Denmark, Institute of Regional Health Services Research, Lillebaelt Hospital, University of Southern Denmark, Middelfart, Denmark
    Eur Spine J 22:697-707. 2013
    Modic type 1 changes/bone edema in the vertebrae are present in 6 % of the general population and 35-40 % of the low back pain population. It is strongly associated with low back pain...
  20. ncbi Relevance of anti-reactive oxygen species activity to anti-inflammatory activity of components of eviprostat, a phytotherapeutic agent for benign prostatic hyperplasia
    Michiko Oka
    Research Laboratories, Nippon Shinyaku Co, Ltd, 14 Nishinosho Monguchi cho, Kisshoin, Minami Ku, Kyoto 601 8550, Japan
    Phytomedicine 14:465-72. 2007
    ..and hydroxyl radical (OH*) generated in cell-free systems and human neutrophils, and on carrageenin-induced paw edema in rats were investigated...
  21. ncbi Isolation and functional characterization of a new myotoxic acidic phospholipase A(2) from Bothrops pauloensis snake venom
    Renata S Rodrigues
    Instituto de Genética e Bioquímica, Universidade Federal de Uberlandia, Uberlandia, MG, Brazil
    Toxicon 50:153-65. 2007
    ..It also induced in vivo edema and myotoxicity...
  22. doi Formulation and evaluation of curcumin gel for topical application
    Nikunjana A Patel
    S K Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India
    Pharm Dev Technol 14:80-9. 2009
    ..05) whereas this effect was not significantly different for CRB and HPC gels formulations to that of standard (diclofenac gel) formulation (P > 0.05). CRB gel showed better % inhibition of inflammation as compared to HPC gel...
  23. doi Peripheral edema associated with calcium channel blockers: incidence and withdrawal rate--a meta-analysis of randomized trials
    Harikrishna Makani
    Division of Cardiology, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA
    J Hypertens 29:1270-80. 2011
    Peripheral edema is considered to be a common and annoying adverse effect of calcium channel blockers (CCBs). It has been thought to occur secondary to arteriolar dilatation causing intracapillary hypertension and fluid extravasation...
  24. doi Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice
    G Kalyan Kumar
    Post Graduate Research Center, Department of Plant Biology and Biotechnology, Presidency College, Chennai, Tamil Nadu, India
    Eur J Pharmacol 662:63-9. 2011
    ..in acute and chronic skin inflammation using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema. Embelin inhibited topical edema in the mouse ear, leading to substantial reductions in skin thickness and tissue ..
  25. pmc Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging
    Anne Kleijn
    Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 17:4484-93. 2011
    ..We aim to establish whether a gadolinium (Gd)-based agent targeting the inflammatory enzyme myeloperoxidase (MPO) can selectively detect intra- and peritumoral inflammation as well as glioma response to treatment by MRI...
  26. ncbi Suppressive effects of propolis in rat adjuvant arthritis
    E H Park
    College of Pharmacy, Sookmyung Women s University, Seoul, Korea
    Arch Pharm Res 22:554-8. 1999
    ..5 mg/kg/day, p.o.) and acetyl salicylic acid (100 mg/kg/day, p.o.). In carrageenan rat hind paw edema, which was conducted to test the effects of subfractions of EEP, the petroleum ether sub-fraction (100 mg/kg, p.o...
  27. doi Protective role of early aquaporin 4 induction against postischemic edema formation
    Lorenz Hirt
    Neurology Department, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    J Cereb Blood Flow Metab 29:423-33. 2009
    ..Its role in edema formation or resolution after stroke onset has been studied mainly at late time points...
  28. doi Anti-inflammatory effects of red pepper (Capsicum baccatum) on carrageenan- and antigen-induced inflammation
    Fernando Spiller
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Pharm Pharmacol 60:473-8. 2008
    ..baccatum juice and our data suggest that this effect may be induced by capsaicin. Moreover, the anti-inflammatory effect induced by red pepper may be by inhibition of pro-inflammatory cytokine production at the inflammatory site...
  29. doi Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats
    Carin Hoffmeister
    Programa de Pós Graduação em Farmacologia, Centro de Ciencias da Saude, Universidade Federal de Santa Maria, RS, Brazil
    Pain 152:1777-88. 2011
    ..04 [95% confidence interval 0.01-0.11]mg/paw) and edema (ED(50)=0.08 [95% confidence interval 0.04-0.16]mg/paw) when injected into the hind paw of rats...
  30. doi Analgesic effects and the mechanisms of anti-inflammation of ergostatrien-3beta-ol from Antrodia camphorata submerged whole broth in mice
    Guan Jhong Huang
    Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, Republic of China
    J Agric Food Chem 58:7445-52. 2010
    ..001). In the anti-inflammatory test, ST1 (10 mg/kg) decreased the paw edema at 4 and 5 h after lambda-carrageenin (Carr) administration and increased the activities of catalase (CAT), ..
  31. ncbi T2-weighted cardiovascular magnetic resonance imaging
    Hassan Abdel-Aty
    Franz Volhard Klinik and Department of Radiology, Charite University Hospital, Berlin, Germany
    J Magn Reson Imaging 26:452-9. 2007
    ..Of these, myocardial edema is of special relevance...
  32. pmc The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa
    Everton Tenório de Souza
    LaFI Laboratório de Farmacologia e Imunidade, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió AL, Brazil
    Mar Drugs 7:689-704. 2009
    ..assays used were the writhing and the hot plate tests, the formalin-induced pain, the capsaicin-induced ear edema and the carrageenan-induced peritonitis. Caulerpin was given orally at a concentration of 100 micromol/kg...
  33. doi Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group
    M Rudwaleit
    Department of Rheumatology, Charite University Medicine, Campus Benjamin Franklin, Berlin, Germany
    Ann Rheum Dis 68:1520-7. 2009
    ..Magnetic resonance imaging (MRI) of sacroiliac joints has evolved as the most relevant imaging modality for diagnosis and classification of early axial spondyloarthritis (SpA) including early ankylosing spondylitis...
  34. pmc Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding
    Zhaochun Chen
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13487-92. 2009
    This study describes the isolation and characterization of a neutralizing monoclonal antibody (mAb) against anthrax edema factor, EF13D...
  35. ncbi Carrageenan-induced paw edema in the rat and mouse
    Christopher J Morris
    University of Bath, UK
    Methods Mol Biol 225:115-21. 2003
  36. ncbi Phorbol ester-induced leukotriene biosynthesis and tumor promotion in mouse epidermis
    G Furstenberger
    Research Program on Tumor Cell Regulation, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Carcinogenesis 15:2823-7. 1994
    ..Intragastric administration of MK-886 prevented phorbol ester-induced ear edema, but not epidermal hyperproliferation and tumor promotion...
  37. ncbi Purification and characterization of a phospholipase A2 isoenzyme isolated from Lachesis muta snake venom
    André L Fuly
    Departamento de Bioquimica Medica, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, RJ, Rio de Janeiro, Brazil
    Biochem Pharmacol 63:1589-97. 2002
    ..It also produces a significant paw edema reaction in rats...
  38. ncbi Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse
    Robert Hannon
    Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary, University of London, Charterhouse Square, EC1M 6BQ, UK
    FASEB J 17:253-5. 2003
    ..There are also gender differences in activated leukocyte behavior in the Anx-1-/- mice that are not seen in the wild-type animals, suggesting an interaction between sex hormones and inflammation in Anx-1-/- animals...
  39. doi Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei
    Carmen Festa
    Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    Org Lett 13:1532-5. 2011
    ..A combined approach, involving Marfey's method, QM J based analysis, and DFT J/(13)C calculations, was used for establishing the absolute configuration of the entire molecule. Solomonamide A showed in vivo anti-inflammatory activity...
  40. pmc Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression
    Inmaculada Posadas
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, via D Montesano 49, Naples 80131, Italy
    Br J Pharmacol 142:331-8. 2004
    ..The present results are the first report on the differential expressions of eNOS, iNOS, COX-1 and COX-2 in response to carrageenan injection in the two phases of the mouse paw oedema...
  41. pmc Direct T2 quantification of myocardial edema in acute ischemic injury
    David Verhaert
    The Ohio State University, Columbus, Ohio 43210, USA
    JACC Cardiovasc Imaging 4:269-78. 2011
    ..To evaluate the utility of rapid, quantitative T2 mapping compared with conventional T2-weighted imaging in patients presenting with various forms of acute myocardial infarction...
  42. pmc Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
    D C Bullard
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Exp Med 183:2329-36. 1996
    ..These mice provide strong evidence for the functional importance of selectins in vivo...
  43. ncbi Upregulation of the water channel aquaporin-4 as a potential cause of postischemic cell swelling in a murine model of myocardial infarction
    Arne Warth
    Institute of Pathology, University Hospital Tubingen, Tubingen, Germany
    Cardiology 107:402-10. 2007
    ..Our findings imply a role of AQP4 in the formation of myocardial edema and this might be important for future prevention and treatment strategies of this distressing situation in order ..
  44. pmc Altered inflammatory responses in leukotriene-deficient mice
    J L Goulet
    Department of Medicine, University of North Carolina, Chapel Hill 27599 7020
    Proc Natl Acad Sci U S A 91:12852-6. 1994
    ..This has important implications for understanding the early events of an inflammatory response and for designing drugs for use in therapeutic intervention...
  45. pmc Cardiac magnetic resonance with edema imaging identifies myocardium at risk and predicts worse outcome in patients with non-ST-segment elevation acute coronary syndrome
    Subha V Raman
    Ohio State University, Columbus, Ohio 43210, USA
    J Am Coll Cardiol 55:2480-8. 2010
    The aim of this study was to define the prevalence and significance of myocardial edema in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS).
  46. ncbi Lid swelling and diplopia as presenting features of orbital sarcoid
    J Biswas
    Medical Research Foundation, 18 College Road, Chennai 600 006, India
    Indian J Ophthalmol 48:231-3. 2000
    ..In the eye, the common sites of involvement are the skin of eyelid, conjunctiva, uveal tract, retina, optic nerve and lacrimal gland...
  47. ncbi Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis
    Esther Jimenez-Boj
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 56:1118-24. 2007
    To investigate the pathologic nature of features termed "bone erosion" and "bone marrow edema" (also called "osteitis) on magnetic resonance imaging (MRI) scans of joints affected by rheumatoid arthritis (RA).
  48. ncbi Risk factors for somnolence, edema, and hallucinations in early Parkinson disease
    Kevin M Biglan
    University of Rochester, Department of Neurology, Rochester, NY 14620, USA
    Neurology 69:187-95. 2007
    ..A secondary finding of the trial was a higher than anticipated development or worsening of somnolence and edema and development of hallucinations.
  49. doi Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy
    Ingo Eitel
    University of Leipzig Heart Center, Department of Internal Medicine Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    JAMA 306:277-86. 2011
    ..Various aspects of its clinical profile have been described in small single-center populations, but larger, multicenter data sets have been lacking so far. Furthermore, it remains difficult to quickly establish diagnosis on admission...
  50. ncbi Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat
    Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643 Pecs, Szigeti u 12, Hungary
    Arthritis Rheum 50:1677-85. 2004
    ..This study was undertaken to examine this systemic "sensocrine" function of neuronally derived somatostatin in chronic inflammation in the Freund's complete adjuvant (CFA)-induced arthritis model...
  51. ncbi Tuftsin fragment 1-3 is beneficial when delivered after the induction of intracerebral hemorrhage
    Jian Wang
    Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794 8651, USA
    Stroke 36:613-8. 2005
    ..In this study, we investigate the protection and efficacy of treatment when MIF is administered 2 hours after collagenase injection...
  52. ncbi TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion
    Mahmoud M Khattab
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Eur J Pharmacol 548:167-73. 2006
    ..TEMPOL), a membrane-permeable superoxide dismutase (SOD) mimetic in carrageenan-induced rat paw edema. Treatment of rats with TEMPOL (15, 30, and 60 mg/kg, 15 min prior to carrageenan) inhibited the paw edema...
  53. pmc Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema
    Alexander S Thrane
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:846-51. 2011
    Aquaporin-4 (AQP4) is a primary influx route for water during brain edema formation...
  54. ncbi Anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams
    C O Okoli
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
    J Ethnopharmacol 109:219-25. 2007
    ..D. Adams (Compositae) was evaluated in rodents using the xylene-induced ear edema, egg albumin- and agar-induced paw edema, formaldehyde-induced arthritis, cotton pellet granuloma, gastric ..
  55. ncbi Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1
    Jocelyne Guay
    Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec H9H 3L1, Canada
    J Biol Chem 279:24866-72. 2004
    ..The results show that the carrageenan-induced edema in the paw elicits an early phase of COX-2 induction in the CNS leading to an increase synthesis in PGD(2), 6-keto-..
  56. ncbi Anti-inflammatory activity of Trichodesma indicum root extract in experimental animals
    James B Perianayagam
    Pharmacognosy and Phytochemistry Division, Faculty of Pharmaceutical Sciences, Guru Jambheshwar University, Hisar 125001, India
    J Ethnopharmacol 104:410-4. 2006
    ..42 and 21.12%, respectively, whereas the indomethacin and dexamethasone inhibited it by 29.29 and 34.13%, respectively. The results obtained suggest marked anti-inflammatory activity of the extract at the dose levels examined...
  57. ncbi Peripheral nitric oxide in carrageenan-induced inflammation
    K Omote
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuoku, 060 8543, Sapporo, Japan
    Brain Res 912:171-5. 2001
    ..that nitric oxide (NO) peripherally produced by different nitric oxide synthase (NOS) isoforms contributes to edema formation and development of hyperalgesia...
  58. ncbi Role of the cell cycle in the pathobiology of central nervous system trauma
    Ibolja Cernak
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Cell Cycle 4:1286-93. 2005
    ..Moreover, delayed systemic administration of flavopiridol significantly reduces brain lesion volume and edema development after TBI...
  59. ncbi Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica
    Wu Yin
    College of Pharmacy, Nanjing University of Traditional Chinese Medicine, 282 HanZhong Road, 210029, Nanjing, PR China
    J Ethnopharmacol 88:205-14. 2003
    ..Brucine N-oxide showed stronger inhibitory effect than brucine in carrageenan-induced rat paw edema, both of them significantly inhibited the release of prostaglandin E2 in inflammatory tissue, reduced acetic acid-..
  60. doi Greater postimplant swelling in small-volume prostate glands: implications for dosimetry, treatment planning, and operating room technique
    Eugene Chung
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 82:1944-8. 2012
    Postimplant prostatic edema has been implicated in suboptimal permanent implants, and smaller prostates have been reported to have worse dosimetric coverage...
  61. ncbi Mechanisms of the inflammatory response
    Edward R Sherwood
    Department of Anesthesiology, University of Texas Medical Branch, The Shriners Hospital for Children, 301 University Boulevard, Galveston, TX 77555 0591, USA
    Best Pract Res Clin Anaesthesiol 18:385-405. 2004
    ..However, these basic science advances have not yet translated into widespread benefit for patients suffering from trauma, sepsis and systemic inflammation...
  62. doi Implant surgery using bone- and mucosa-supported stereolithographic guides in totally edentulous jaws: surgical and post-operative outcomes of computer-aided vs. standard techniques
    Volkan Arisan
    Department of Oral Implantology, Faculty of Dentistry, Istanbul University, Capa, Istanbul, Turkey
    Clin Oral Implants Res 21:980-8. 2010
    ..The aim of this study was to compare the surgical and post-operative outcomes of a computer-aided implant surgery performed by bone- and mucosa-supported stereolithographic (SLA) guides against the standard technique...
  63. doi Formation of painful seroma and edema after the use of recombinant human bone morphogenetic protein-2 in posterolateral lumbar spine fusions
    Mark P Garrett
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013 4496, USA
    Neurosurgery 66:1044-9; discussion 1049. 2010
    ..The use of bone morphogenetic proteins for fusion augmentation in spine surgery has increased dramatically in recent years. Information is continually emerging regarding the effectiveness and safety profile of these compounds...
  64. ncbi Vascular endothelial growth factor serum level is strongly enhanced after burn injury and correlated with local and general tissue edema
    Manfred Infanger
    Department of Trauma and Reconstructive Surgery, Charite University Medicine Berlin, Benjamin Franklin Campus, Hindenburgdamm 30, D 12200 Berlin, Germany
    Burns 30:305-11. 2004
    Burn associated local and general tissue edema is induced by local cell destruction and capillary leak syndrome. Vascular endothelial growth factor (VEGF) strongly enhances vascular permeability as well as angiogenesis...
  65. pmc CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice
    Ivan Zanoni
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy
    J Clin Invest 122:1747-57. 2012
    ..b>Edema formation is one of the first steps in the inflammatory response; it is fundamental for the local accumulation of ..
  66. ncbi Effect of dexamethasone associated with serum therapy on treatment of Bothrops jararaca venom-induced paw edema in mice
    S Dias Araújo
    Laboratorio de Fisiopatologia, Instituto Butantan, Av Vital Brazil, 1500, 05503 900, Sao Paulo, SP, Brazil
    Inflamm Res 56:409-13. 2007
    The present study investigates the supposed advantage of using an association of anti-inflammatory drugs and serum therapy to treat mouse paw edema induced by injection of Bothrops jararaca snake venom (BjV).
  67. ncbi Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract
    Eun Mi Choi
    Department of Food and Nutrition, Kyunghee University, Hoegi dong, Dongdaemun Gu, Seoul, Korea
    Phytother Res 21:471-5. 2007
    ..Antiinflammatory effects were evaluated using carrageenan- and formalin-induced paw edema, and arachidonic acid-induced ear edema in mice. The ethanol extract of pine pollen (100 and 200 mg/kg, p.o...
  68. pmc Severe malnutrition with and without HIV-1 infection in hospitalised children in Kampala, Uganda: differences in clinical features, haematological findings and CD4+ cell counts
    Hanifa Bachou
    Department of Paediatrics and Child Health, Makerere University Medical School, P O Box 7072, Kampala, Uganda
    Nutr J 5:27. 2006
    ..The aim of this study was to describe the clinical features, haematological findings and CD4+ and CD8+ cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) infection...
  69. doi Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum
    P Antonisamy
    Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India
    Phytomedicine 17:300-4. 2010
    ..The anti- oedema effect was compared with indomethacin. Violacein inhibited 42.9% of ovalbumin- induced edema. Further we found that violacein (40mg/kg b.w.) reduced the edema induced by sheep red blood cells...
  70. ncbi Repeated topical application of growth hormone attenuates blood-spinal cord barrier permeability and edema formation following spinal cord injury: an experimental study in the rat using Evans blue, ([125])I-sodium and lanthanum tracers
    F Nyberg
    Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Amino Acids 23:231-9. 2002
    ..of growth hormone on a focal spinal cord trauma induced alteration in the blood-spinal cord barrier (BSCB) and edema formation was examined in a rat model...
  71. doi Transient soft-tissue edema associated with implantation of increasing doses of rhBMP-2 on an absorbable collagen sponge in an ectopic rat model
    Hyun W Bae
    Spine Center, Division of Orthopaedic Surgery, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Bone Joint Surg Am 94:1845-52. 2012
    Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive protein. However, soft-tissue edema adjacent to the site of rhBMP-2 implantation has been reported...
  72. pmc Protection of piglets against Edema disease by maternal immunization with Stx2e toxoid
    Thi Kim Nguyen Oanh
    Department of Biosystems, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Heverlee, Belgium
    Infect Immun 80:469-73. 2012
    b>Edema disease (ED) in piglets is caused by Shiga toxin Stx2e-producing Escherichia coli. We show that a genetically disarmed Stx2e toxoid is a safe antigen that generates antiserum protecting piglets against the Stx2e toxin...
  73. doi Anti-inflammatory effects and acute toxicity of hydroethanolic extract of Jacaranda decurrens roots in adult male rats
    Joyce Alencar Santos
    School of Health Sciences, Federal University of Grande Dourados, Dourados MS, Brazil
    J Ethnopharmacol 144:802-5. 2012
    ..Jacaranda decurrens subsp. symmetrifoliolata Farias and Proença (Bignoniaceae) is a species traditionally used for the treatment of inflammatory diseases. However, until this moment, there is no scientific evidence of these effects...
  74. doi Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators
    Hany H Arab
    Biochemistry Division, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taif University, Taif, Saudi Arabia
    Toxicol Appl Pharmacol 268:241-8. 2013
    ..Two models were studied in the same rat; adjuvant arthritis and subcutaneous air pouch edema. Carvedilol (10mg/kg/day p.o...
  75. pmc Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine
    D L Weinstein
    Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799
    J Bacteriol 170:4223-30. 1988
    A Shiga-like toxin type II variant (SLT-IIv) is produced by strains of Escherichia coli responsible for edema disease of swine and is antigenically related to Shiga-like toxin type II (SLT-II) of enterohemorrhagic E. coli...
  76. ncbi Leucaena leucocephala serine proteinase inhibitor: primary structure and action on blood coagulation, kinin release and rat paw edema
    M L Oliva
    Departamento de Bioquimica, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, 04044 020, Sao Paulo, Brazil
    Biochim Biophys Acta 1477:64-74. 2000
    ..weight kininogen by human plasma kallikrein in vitro and, administered intravenously, causes a decrease in paw edema induced by carrageenin or heat in male Wistar rats...
  77. pmc TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse
    Lauri J Moilanen
    The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland
    Sci Rep 2:380. 2012
    ..Here, we tested the hypothesis that TRPA1 is involved in acute inflammatory edema. The TRPA1 agonist allyl isothiocyanate (AITC) induced inflammatory edema when injected intraplantarly to mice, ..
  78. doi Anti-inflammatory effect of transduced PEP-1-heme oxygenase-1 in Raw 264.7 cells and a mouse edema model
    Soon Won Kwon
    Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Republic of Korea
    Biochem Biophys Res Commun 411:354-9. 2011
    ..7 cells and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse edema model, transduced PEP-1-HO-1 fusion proteins effectively inhibited the overexpression of pro-inflammatory ..
  79. ncbi Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection
    Jelena Lazovic
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Stroke 36:2226-31. 2005
    ..We hypothesized that abrogating IL-1 type 1 receptor (IL-1R1) signaling would reduce edema, chemokine expression, and leukocyte infiltration; lower levels of iNOS; and, consequently, decrease free radical ..
  80. doi Effect of low-level laser therapy in the inflammatory response induced by Bothrops jararacussu snake venom
    Ana Maria Barbosa
    Laboratory of Inflammation, Institute of Research and Development, University of Vale do Paraiba, Av Shishima Hifumi, 2911, Urbanova, CEP 12244 000, Sao Jose dos Campos, SP, Brazil
    Toxicon 51:1236-44. 2008
    This article reports the effect of low-level laser therapy (LLLT) on the edema formation and leukocyte influx caused by Bothrops jararacussu snake venom as an alternative treatment for Bothrops snakebites...
  81. doi Bone marrow edema is the most specific finding for rheumatoid arthritis (RA) on noncontrast magnetic resonance imaging of the hands and wrists: a comparison of patients with RA and healthy controls
    Ewa Olech
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Rheumatol 37:265-74. 2010
    To evaluate the sensitivity and specificity of magnetic resonance imaging (MRI) in detecting erosions, bone edema, and synovitis in the metacarpophalangeal and wrist joints for rheumatoid arthritis (RA).
  82. doi Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat
    Shamsherjit Kaur
    Department of Pharmacology, ISF College of Pharmacy, Moga, 142001, Punjab, India
    Inflammopharmacology 19:265-72. 2011
    ..The present study was designed to investigate the anti-inflammatory and antihyperalgesic effects of the prophylactic use of hemin alone and/or in combination with ibuprofen using adjuvant-induced arthritis in Wistar rat...
  83. doi Planning based on postneedle volume with early dosimetric assessment is beneficial for Cesium-131 permanent prostate seed implantation
    Ryan P Smith
    Department of Radiation Oncology, University of Pittsburgh Medical Center, St Maragret s Hospital, 815 Freeport Road, Pittsburgh, PA 15238, USA
    Brachytherapy 7:237-41. 2008
    This study reports on prostate edema after prostate brachytherapy using Cesium-131 ((131)Cs) and describes our method to compensate.
  84. pmc Compartmental relaxation and diffusion tensor imaging measurements in vivo in lambda-carrageenan-induced edema in rat skeletal muscle
    Reuben H Fan
    Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, TN 37232 2310, USA
    NMR Biomed 21:566-73. 2008
    ....
  85. ncbi The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death
    H Putaala
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Hum Mol Genet 10:1-8. 2001
    ..Although seemingly normal at birth, they immediately developed massive proteinuria and edema and died within 24 h...
  86. doi Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model
    P Pratheesh Kumar
    Amala Cancer Research Centre, Amala Nagar, Kerala State, India
    Immunopharmacol Immunotoxicol 31:94-102. 2009
    ..Down regulation of pro-inflammatory cytokine level and gene expression were also support the above result...
  87. ncbi Electroacupuncture inhibits inflammatory edema and hyperalgesia through regulation of cyclooxygenase synthesis in both peripheral and central nociceptive sites
    Jun Hyuk Lee
    Department of Anatomy, College of Oriental Medicine, Dong Eui University, Busan 614 052, Korea
    Am J Chin Med 34:981-8. 2006
    ..EA with 2, 15 and 120 Hz, especially 2 Hz, had significant inhibitory effects on the developing of edema and hyperalgesia, which was measured in 30-min intervals after carrageenan injection...
  88. doi Placental growth factor contributes to bronchial neutrophilic inflammation and edema in allergic asthma
    Sonja Bobic
    Department of Otorhinolaryngology and Head and Neck Surgery, Catholic University Hospitals, Kapucijnevoer 33, Leuven, Belgium
    Am J Respir Cell Mol Biol 46:781-9. 2012
    ..This study investigated their contributions to inflammation and the formation of edema in allergic asthma...
  89. ncbi Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema
    Zekai Halici
    Faculty of Medicine, Department of Pharmacology, Ataturk University, 25240, Erzurum, Turkey
    Eur J Pharmacol 566:215-21. 2007
    ..inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced paw edema. In the present study, we found that 1) Amiodarone reduced the development of carrageenan-induced paw edema, to a ..
  90. doi Anti-inflammatory and analgesic activities of the aqueous extract of Acacia karroo stem bark in experimental animals
    Adeolu A Adedapo
    Agricultural and Rural Development Research Institute, University of Fort Hare, Alice, South Africa
    Basic Clin Pharmacol Toxicol 103:397-400. 2008
    ..Indomethacin at 10 mg/kg served as reference drug in all these tests. The results gave a scientific basis to the traditional uses of Acacia karroo mainly for wound poultices, eye treatments and cold remedies...
  91. pmc Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model
    Rakesh K Jain
    E L Steele Lab for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 67:2729-35. 2007
    ..Finally, decreased fluid convection into the peritumor tissue would decrease peritumor edema associated with brain tumors and ascites accumulation in the peritoneal or pleural cavity, a major complication ..
  92. pmc Apelin attenuates UVB-induced edema and inflammation by promoting vessel function
    Mika Sawane
    Shiseido Innovative Science Research Center, Yokohama, Japan
    Am J Pathol 179:2691-7. 2011
    ..transgenic mice harboring apelin under the control of keratin 14 (K14-apelin) exhibited attenuated UVB-induced edema and a decreased number of CD11b-positive macrophages...
  93. pmc Blood is thicker than lymph
    Mark L Kahn
    Department of Medicine and University of Pennsylvania Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:23-6. 2008
    ..and Ichikawa-Shindo et al. demonstrate that loss of signaling by the adrenomedullin peptide results in embryonic edema and death (see the related articles beginning on pages 40 and 29, respectively)...
  94. pmc Mouse monoclonal antibodies to anthrax edema factor protect against infection
    Clinton E Leysath
    Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Building 33 Room 1W20B 7, Bethesda, MD 20892 3202, USA
    Infect Immun 79:4609-16. 2011
    ..b>Edema factor (EF), a potent adenylyl cyclase, is one of the toxin components...
  95. doi Risk of laryngeal edema and facial swellings after tooth extraction in patients with hereditary angioedema with and without prophylaxis with C1 inhibitor concentrate: a retrospective study
    Konrad Bork
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:58-64. 2011
    ..The aim of this study was to determine how many tooth extractions were followed by symptoms of HAE-C1-INH in patients with and without preoperative short-term prophylaxis with C1 inhibitor concentrate...
  96. pmc Requirement of alpha(4)beta(1) and alpha(5)beta(1) integrin expression in bone-marrow-derived progenitor cells in preventing endotoxin-induced lung vascular injury and edema in mice
    Kishore K Wary
    Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illinois, Chicago, Illinois 60612, USA
    Stem Cells 27:3112-20. 2009
    ..We used a mouse model of bacterial lipopolysaccharide (LPS)-induced lung vascular injury and edema formation to test the effects of BMPC integrin expression in preventing endothelial barrier injury...
  97. doi Time course of prostatic edema post permanent seed implant determined by magnetic resonance imaging
    Ron S Sloboda
    Department of Medical Physics, Cross Cancer Institute, Edmonton, Alberta, Canada
    Brachytherapy 9:354-61. 2010
    To quantify the time course of postimplant prostatic edema magnitude and spatial isotropy using serial magnetic resonance imaging (MRI).
  98. doi Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein-2 in cranial reconstruction for craniosynostosis. Case report
    M Mohsin Shah
    Division of Neurosurgery, University of Missouri Columbia, Columbia, MO 65203, USA
    J Neurosurg Pediatr 1:255-7. 2008
    The authors present a case of scalp and facial edema following craniofacial reconstruction for metopic craniosynostosis in which recombinant human bone morphogenetic protein-2 (rhBMP-2) was used to treat cranial defects related to the ..
  99. doi Quality of life after microscopic periradicular surgery using two different incision techniques: a randomized clinical study
    M Del Fabbro
    Department of Health Technologies, IRCCS Istituto Ortopedico Galeazzi, University of Milan, Milan, Italy
    Int Endod J 42:360-7. 2009
    ..To monitor the quality of life of patients after periradicular surgery when two different flap designs were used...
  100. doi Effect of aliskiren addition to amlodipine on ankle edema in hypertensive patients: a three-way crossover study
    Roberto Fogari
    Clinica Medica II, University of Pavia, Centro Ipertensione e Fisiopatologia Cardiovascolare, Department of Internal Medicine and Therapeutics, Pavia, Italy
    Expert Opin Pharmacother 12:1351-8. 2011
    ..The aim of this study was to assess the effect of aliskiren and amlopidine on ankle-foot volume (AFV) and pretibial subcutaneous tissue pressure (PSTP)...
  101. doi Anti-inflammatory activities of 6β-acetoxy-7α-hydroxyroyleanone from Taiwania cryptomerioides Hayata ex vivo and in vivo
    Guan Jhong Huang
    School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan
    J Agric Food Chem 59:11211-8. 2011
    ..7) ex vivo and carrageenan (Carr)-induced mouse paw edema model in vivo. When RAW 264.7 macrophages were treated with different concentrations of AHR (0, 0.31, 0.62, 1...

Research Grants75

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Title: A Phase II Randomized Study to Compare Anti-VEGF Agents in the Treatment of Diabetic Macular Edema (CADME) Number: 12-EI-0134 Background: - Diabetic macular edema is a common eye complication of diabetes...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Title: A Phase II Randomized Study to Compare Anti-VEGF Agents in the Treatment of Diabetic Macular Edema (CADME) Number: 12-EI-0134 Background: - Diabetic macular edema is a common eye complication of diabetes...
  3. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..T2 weighted MRI at 2 days will determine area of edema in vivo, while gadolinium plus tissue tagging at 7 days will determine in vivo myocardial scar and function in ..
  4. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Kidney disease that is identified by the appearance of large amounts of protein in the urine, edema or swelling of tissues, low plasma proteins and increased cholesterol is termed nephrotic syndrome...
  5. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..at the start of resuscitation completely prevented T/HS-induced lung AEC apoptosis, decreased inflammation and edema as well as susceptibility to pneumonia, and decreased mortality 5-fold...
  6. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..also induces a widespread expresion of pro-inflammatory genes that contribute to vascular permeability, lung edema, neutrophil infiltration, pulmonary shunt, and respiratory failure...
  7. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..also induces a widespread expression of pro-inflammatory genes that contribute to vascular permeability, lung edema, neutrophil infiltration, pulmonary shunt, and respiratory failure...
  8. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..IRI is associated with early increased endothelial permeability and edema and later, changes in gene expression, resulting in inflammation...
  9. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..b>Edema and hemorrhagic disease found in DHF/DSS result from vascular leakage, and these severe manifestations are ..
  10. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..Recipient rats will be evaluated for a) wet/dy weight ratio (W/D) (a measure of pulmonary edema), b) oxygenation by the graft, c) graft pulmonary vascular resistance, d) dynamic compliance, and e) lung tissue ..
  11. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..The principal clinical manifestation of ARDS and ALI is edema, which results from endothelial dysfunction and microvasculature permeability...
  12. Role of the kallikrein-kinin system in diabetic retinopathy
    Edward P Feener; Fiscal Year: 2012
    Excessive retinal vascular permeability contributes to the pathogenesis of diabetic macular edema (DME), a leading cause of vision loss in working-age adults...
  13. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..Development of an office-based treatment technology to diagnosis subglottic stenosis or monitor its development would reduce the need for morbidity and decrease health care costs. ..
  14. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..Preeclampsia (PE) is a serious complication of pregnancy manifested by high blood pressure, proteinuria, and edema, sometimes with encephalopathy, seizures, and hepatic failure...
  15. Novel Means to Establish Free Radical Balance in the Neonatal Premature Lung
    Prakash Jagtap; Fiscal Year: 2011
    ..of the premature infant, wherein the lung is developmentally unprepared for ex utero function and rapidly develops edema, poor compliance, pulmonary arterial hypertension (PAH), and impaired gas exchange...
  16. Angiogenesis in the Lung
    Elizabeth Wagner; Fiscal Year: 2010
    ..occurs in many pulmonary diseases such as asthma, cystic fibrosis, and chronic thromboembolism where inflammation, edema, and hemoptysis contribute to lung pathology...
  17. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..for clinical evidence of arthritis over a period of 6 weeks, a timepoint characterized in controls by erythema and edema of the entire paw including digits (score=12)...
  18. Pluripotent human stem cells as models for normal and diseased trophoblast
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..It is characterized by maternal hypertension, edema, and proteinuria, conditions that in the more serious, early onset disease can manifest as soon as 20 weeks of ..
  19. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..Neither the degree of acute BBB opening, predictive of severe vasogenic edema and HT, nor the physiological changes in the BBB components that contribute to these altered MRI signals are known...
  20. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances E Jensen; Fiscal Year: 2010
    ..Vigabatrin also appears to induce injury to white matter tracts (intramyelinic edema) in animal models and MRI white matter abnormalities in human patients...
  21. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..Disease relevance of trainee projects are numerous;eg. coronary ischemia, asthma, pulmonary edema, hypertension, cardiac failure, intestinal vascular inflammation, pulmonary fibrosis, peripheral vascular disease, ..
  22. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
    ..The anthrax toxins, protective antigen (PA) combined with lethal factor (LF) and edema factor (EF) are able to enter the cytoplasm of phagocytic cells and impair their function...
  23. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    DAVID ANTONETTI; Fiscal Year: 2013
    ..this proposal is to understand the molecular mechanisms that lead to increased vascular permeability and macular edema and to elucidate the relationship of vascular permeability to angiogenesis so that novel therapies to treat or ..
  24. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..epithelial cell barrier contributes to other sequelae observed in acute lung injury, including pulmonary edema, airway obstruction, inflammation, and respiratory infections...
  25. Development of an effective therapy against post-exposure Anthrax
    Maurizio Pellecchia; Fiscal Year: 2010
    ..of protective antigen (PA), lethal factor (LF, a Zn2+ dependant metalloproteinase) and calmodulin-activated edema factor adenylate cyclase (EF)...
  26. Mechanisms of endothelial barrier phenotypes in sickle cell disease
    SOLOMON FIIFI OFORI-ACQUAH; Fiscal Year: 2013
    ..and heme) generates oxidative stress, which is well known to increase endothelial permeability and cause tissue edema. In preliminary studies we found increased endothelial permeability and pulmonary edema in two transgenic models ..
  27. Reperfusion and Neurovascular Injury in Stroke
    Pak H Chan; Fiscal Year: 2013
    ..stroke event is known to produce ROS that can cause neurovascular injury, BBB disruption with secondary vasogenic edema, and hemorrhagic transformation of infarcted brain tissue...
  28. Rho-Modifying Cytotoxic Necrotizing Factor of E. coli
    ALISON DAVIS O'BRIEN; Fiscal Year: 2013
    ..eliciting submucosal edema (CNF1). The specific aims designed to test this hypothesis are to: 1...
  29. GILZ Regulation of ENaC
    David Pearce; Fiscal Year: 2012
    ..This work will shed new light on the basic mechanisms, and provide avenues for better treatment of high blood pressure and edema.
  30. Analyzing Anthrax Toxins in Drosophilia
    Ethan Bier; Fiscal Year: 2013
    ..made a paradigm shifting discovery in which we showed that the two key virulence factors from Bacillus anthracis, edema factor (EF) and lethal factor (LF) act cooperatively to inhibit protein trafficking to cell-cll junctions...
  31. Plasminogen activators and NMDA after brain injury
    William M Armstead; Fiscal Year: 2012
    ..NMDA receptor mediated effects on CBF in an age dependent manner leading to impaired cerebral hemodynamics and edema followed by neuronal cell loss...
  32. Prevention and Treatment of Chlorine Gas Induced Injury to the Pulmonary System
    Sadis Matalon; Fiscal Year: 2011
    ..However, following this latency period, severe lung injury, characterized by protein-rich edema and the onset of hypoxemia may develop...
  33. Regulatory targets and pathogenic mechanisms of anthrax edema factor
    Jin Mo Park; Fiscal Year: 2011
    ..the causative agent of anthrax, produces three toxin polypeptides: protective antigen (PA), lethal factor (LF) and edema factor (EF). PA binds to receptors expressed on the surface of host cells and allows cellular entry of LF and EF...
  34. Regulation of ENaC Transcription
    Bruce C Kone; Fiscal Year: 2013
    ..Abnormal expression levels of this protein can result in hypertension, potassium deficiency, and edema. This proposal examines a novel network of interacting proteins in the cell nucleus that regulate transcription, ..
  35. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Brain edema and associated intracranial hypertension are major complications of acute liver failure (ALF), which has a high mortality and for which therapeutic options are largely limited to an ..
  36. Transscleral Transport & Polymeric Delivery of Antibody & Steroids for Macular Ed
    Ashim K Mitra; Fiscal Year: 2010
    ..by applicant): Repeated intravitreal injections of steroids and anti-VEGF agents in the treatment of macular edema, pose potential post-surgical problems...
  37. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..infects endothelial cells (ECs) and HPS is characterized by thrombocytopenia, hypoxia and acute pulmonary edema that leads to respiratory insufficiency...
  38. Decompressive craniotomy versus medical therapy for refractory intracranial hyper
    Raminder Nirula; Fiscal Year: 2010
    ..1-4 Therapies to reduce cerebral edema and the discrepancy between cerebral oxygen delivery and consumption, such as osmotic diuresis, hyperosmolar ..
  39. Mesonephric Model of Podocyte Injury and Regeneration
    Weibin Zhou; Fiscal Year: 2012
    ..Nephrotic syndrome (NS) is a kidney disease characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia, due to the disruption of renal glomerular filtration barrier (GFB) function...
  40. The Roles of Conserved outer-membrane proteins in SFG rickettsia pathogenesis
    Juan J Martinez; Fiscal Year: 2013
    ..especially in the lungs and brain can result in the most severe manifestations of disease including pulmonary edema and interstitial pneumonia...
  41. Molecular Basis of Nuchal Edema
    Young Kwon Hong; Fiscal Year: 2013
    Nuchal edema (NE) is a tissue swelling on the back of the neck of fetus due to an abnormal fluid accumulation during human pregnancy and has been associated with fetuses having chromosomal aneuploidy...
  42. Mechanisms of ENaC Inhibition by Replicating Influenza Virus: Role of M2 Protein
    Sadis Matalon; Fiscal Year: 2012
    ..It has been thought that these events are responsible for flu-induced rhinorrhea and life-threatening alveolar edema in humans...
  43. Effect of cardioplegia and cardiopulmonary Bypass on coronary microvascular react
    Frank W Sellke; Fiscal Year: 2013
    ..vascular permeability factor (VEGF/VPF) are increased in expression in diabetes and are associated with increased edema formation and length of hospital stay in diabetic patients...
  44. Heme Oxygenase-1 in Lung Ischemia-Reperfusion Injury
    Patty J Lee; Fiscal Year: 2012
    ..injury during lung transplantation/surgery, thromboembolectomy, pulmonary embolism, and re-expansion pulmonary edema, all of which lead to clinically significant respiratory failure but for which no specific therapies exist...
  45. Preventing lethal hemorrhagic fever caused by hantaviruses by preserving endothel
    ALAN L MUELLER; Fiscal Year: 2012
    ..The loss of vascular integrity results in non-cardiogenic edema, shock, multi-organ failure and death...
  46. (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION: FETUS AND ADULT
    Lawrence D Longo; Fiscal Year: 2013
    ..mechanisms of diseases, including: Acute Mountain Sickness, Preeclampsia, and High Altitude Cerebral and Pulmonary Edema. PUBLIC HEALTH RELEVANCE: Scientifically, the studies will augment our understanding of basic mechanisms whereby ..
  47. Advancing a Lead Candidate Hantavirus Pulmonary Syndrome DNA Vaccine
    JAY WILLIAMS HOOPER; Fiscal Year: 2013
    ..HPS in humans including: incubation time, rapid onset/progression, target tissue (endothelium), pulmonary edema, pleural effusion, and shock...
  48. Regulation of Endothelial ICAM-1 and PMN-Mediated Lung Injury by Actin Dynamics
    Fabeha Fazal; Fiscal Year: 2013
    ..by this mechanism contributes to lung PMN sequestration and PMN-mediated lung vascular injury and tissue edema in mice. We will pursue the following specific aims to test this hypothesis...
  49. Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity
    Sven Eric Jordt; Fiscal Year: 2013
    ..injury and cardiovascular depression, and we show that a TRPV4 antagonist inhibits ozone induced oxidative lung edema. TRPV3, a TRP ion channel in keratinocytes, is a candidate mediator of cutaneous injury by vesicants and corrosive ..
  50. A novel axis regulates adipocyte plasticity
    Sean Hartig; Fiscal Year: 2013
    ..increases insulin sensitivity and fat storage efficiency in T2DM with serious, negative side effects including edema, bone loss, bladder cancer, and heart failure...
  51. Detoxification of Electrophilic Chemical Threat Agents by Nucleophilic Scavengers
    Michael C MacLeod; Fiscal Year: 2010
    ..Toxicity endpoints in the mouse tissues will include histopathology (pyknotic/apoptotic nuclei, edema, vesication, infiltration, fibrosis) and induction of mutations in reporter genes carried in the transgenic ..
  52. Analysis of alphaVbeta8 Integrin In Gliomagenesis
    Joseph H McCarty; Fiscal Year: 2012
    ..other high-grade gliomas develop severe blood vessel pathologies, including abnormal angiogenesis and associated edema and hemorrhage...
  53. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    David Stump; Fiscal Year: 2013
    ..The outcomes will include: brain edema;intravital visualization and recording of intravascular emboli;BBB leakage into the cerebrospinal fluid;emboli ..
  54. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    William Brown; Fiscal Year: 2009
    ..The outcomes will include: brain edema; intravital visualization and recording of intravascular emboli;BBB leakage into the cerebrospinal fluid; emboli ..
  55. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..In neither mouse, however, are differences from WT found in measures of the severity (edema, T cell and neutrophil infiltration, and expression of IL1 , IFN , and TNF ) of delayed type hypersensitivity ..
  56. Fetal HCMV Infection: Role of the Human Placenta
    LENORE PALMA PEREIRA; Fiscal Year: 2013
    ..The placentas are damaged from inflammation, edema, hypoxia, and fibrosis...
  57. The effects of dexamethasone on tumor and microglial cells in glioma
    TERREIA SUTTON JONES; Fiscal Year: 2013
    ..and their secreted products;3) To determine whether Dex antagonizes the anti-tumor effect of standard therapy;and 4) To determine whether compounds targeting microglia function in vivo can lead to a comparable edema reduction as Dex.
  58. Development and testing of polyvalent anthrax toxin inhibitors
    JEREMY S MOGRIDGE; Fiscal Year: 2012
    ..Heptamerization allows binding of the enzymatic toxin components, edema factor and lethal factor, and triggers endocytosis of these complexes and intoxication of the cells...
  59. Cellular Mechanisms of Lymphatic Muscle Contractility
    MICHAEL JOHN DAVIS; Fiscal Year: 2012
    ..Dysfunction of the lymphatic pump system is associated with edema, pain, lack of mobility, and increased risk of infection[unreadable]conditions that affect more than 10 million ..
  60. Tie2 Activation for the Treatment of Chemical-Induced Acute Lung Injury
    Christopher D Kontos; Fiscal Year: 2013
    ..to phosgene gas causes acute lung injury (ALI) that primarily targets alveoli, resulting in acute pulmonary edema and fatal acute respiratory distress syndrome...
  61. TRAFFIC REGULATORY PROTEINS AND ENAC
    Raymond A Frizzell; Fiscal Year: 2013
    ..are implicated in significant human diseases, including hypertension, nephrosis, cystic fibrosis and pulmonary edema. In renal and airway epithelia, ENaC activity is regulated by factors that control the number of active channels ..
  62. Nutrition Intervention to Reduce Symptoms in Patients with Advanced Heart Failure
    Terry A Lennie; Fiscal Year: 2013
    ..controlled study are 1) to determine the effects of a 6-month nutrition intervention on symptom burden (edema, shortness of air, and fatigue) and health related quality of life at 3 and 6 months, and time to heart failure ..
  63. Sphingosine 1-Phosphate: A New Target for Early Diabetic Retinopathy
    Arup Das; Fiscal Year: 2013
    ..S1P) in diabetic retinopathy, and identify novel targets for the treatment of this blinding condition, macular edema. Pericyte loss is the classic histologic finding of early diabetic retinopathy in the human retina...
  64. Autologous TGF-B-Modified HSC for Repair of Vasodegenerative Diabetic Retinopathy
    STEPHEN BARTELMEZ; Fiscal Year: 2009
    ..provided by applicant): Diabetic retinopathy induces retinal vascular endothelial damage resulting in ischemia, edema, and hemorrhage. Current available treatments for diabetic retinopathy are focused on end-stages of the disease...
  65. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    DESCRIPTION (Applicant's abstract): Pulmonary edema (too much fluid in the lungs) is one of the most common and serious complications of heart failure...
  66. CNS INJURY AND EDEMA RESEARCH CENTER
    Pak Chan; Fiscal Year: 2007
    ..leading to damage of the neurovascular unit that causes blood-brain barrier disruption, with secondary vasogenic edema and hemorrhagic transformation of infarcted brain tissue, restricting the benefit of tissue reperfusion with ..
  67. NEUROGENIC INFLUENCES ON LUNG FLUID AND SOLUTE EXCHANGE
    Fred Minnear; Fiscal Year: 1990
    ..and acute pulmonary vascular hypertension have been postulated as mechanisms in the development of pulmonary edema after a variety of clinical syndromes such as subarachnoid hemorrhage, intracranial hypertension, cerebral ..
  68. Intervention against anthrax edema factor (EF)
    Wei Jen Tang; Fiscal Year: 2005
    ..Two major anthrax toxins, edema toxin (EdTx) and lethal toxin (LeTx) alter intracellular signaling...
  69. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..pulmonary blood flow and increased pulmonary capillary pressures interact to affect the development of pulmonary edema. High altitude pulmonary edema (HAPE), an acute potentially fatal edema is used as a disease model, to allow ..
  70. PATHOGENESIS OF HERPETIC KERATITIS
    WILLIAM O BRIEN; Fiscal Year: 2002
    ..This application focuses on the mechanism(s) by which HSV infections induce corneal edema, the most common complication of herpetic keratitis...
  71. CONTROL OF CEREBRAL REPERFUSION AFTER CARDIAC ARREST
    Peter Safar; Fiscal Year: 1990
    ..global hypoperfusion are key factors in permanent brain damage; that blood brain barrier leakage and cerebral edema may be factors in reduced blood flow; and that control of post-CA perfusion failure and edema can improve outcome...
  72. ROLE OF LEUKOTRIENES IN ACUTE LUNG INJURY
    Randy Sprague; Fiscal Year: 1991
    ..on the role of products of lipoxygenase-mediated arachidonic acid metabolism as endogenous mediators of edema formation in acute lung injury (ALI)...
  73. Prostate Edema in Permanent Interstitial Brachytherapy
    Zhe Chen; Fiscal Year: 2010
    ..In prostate PIB, however, variation in post-implant source position is inevitable because edema induced by the surgical procedure causes the prostate gland to swell rapidly (to as large as twice of its pre-..
  74. ADVERSE EVENTS WITH MAGNESIUM SULFATE
    George Macones; Fiscal Year: 2000
    ..While MgSO4 is felt to have a tolerable side-effect profile, there is a risk of pulmonary edema (the most dangerous adverse event) with its use with estimates as high as 8%...
  75. MECHANISMS OF FLUID BALANCE IN LOWER VERTEBRATE LUNGS
    ALLAN SMITS; Fiscal Year: 1991
    ..abstract) One of the most life-threatening clinical conditions in respiratory medicine today is pulmonary edema, in which an accumulation of fluid in the lung tissue greatly impedes the diffusion of oxygen and carbon dioxide ..