vomiting

Summary

Summary: The forcible expulsion of the contents of the STOMACH through the MOUTH.

Top Publications

  1. doi Chemotherapy-induced nausea and vomiting
    Paul J Hesketh
    Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    N Engl J Med 358:2482-94. 2008
  2. ncbi Antiemetics: American Society of Clinical Oncology clinical practice guideline update
    Ethan Basch
    Memorial Sloan Kettering Cancer Center, New York, USA
    J Clin Oncol 29:4189-98. 2011
  3. ncbi Pharmacological mechanisms of 5-HT₃ and tachykinin NK₁ receptor antagonism to prevent chemotherapy-induced nausea and vomiting
    Camilo Rojas
    Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6515, USA
    Eur J Pharmacol 684:1-7. 2012
  4. ncbi Update and new trends in antiemetic therapy: the continuing need for novel therapies
    P Feyer
    Department of Radiooncology, Nuclear Medicine, Vivantes Clinics Berlin Neukölln, Berlin
    Ann Oncol 22:30-8. 2011
  5. ncbi Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron
    Peter Eisenberg
    California Cancer Care, Greenbrae, California, USA
    Cancer 98:2473-82. 2003
  6. ncbi Risk of functional gastrointestinal disorders in U.S. military following self-reported diarrhea and vomiting during deployment
    Chad K Porter
    Enteric Diseases Department, Infectious Disease Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Dig Dis Sci 56:3262-9. 2011
  7. ncbi Spectrum of use and tolerability of 5-HT3 receptor antagonists
    U Haus
    Novartis Pharma GmbH, Nuremberg, Germany
    Scand J Rheumatol Suppl 119:12-8. 2004
  8. ncbi Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with cisplatin therapy: randomized, double-blind study protocol--EASE
    Steven Grunberg
    University of Vermont, Dept of Medicine, Fletcher Allen Health Care, 89 Beaumont Ave, Given Bldg E 214, Burlington, VT 05405, USA
    J Clin Oncol 29:1495-501. 2011
  9. ncbi Susceptibility to winter vomiting disease: a sweet matter
    Gustaf E Rydell
    Dept of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Rev Med Virol 21:370-82. 2011
  10. pmc Neuromyelitis optica unique area postrema lesions: nausea, vomiting, and pathogenic implications
    B F Gh Popescu
    Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Neurology 76:1229-37. 2011

Detail Information

Publications317 found, 100 shown here

  1. doi Chemotherapy-induced nausea and vomiting
    Paul J Hesketh
    Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    N Engl J Med 358:2482-94. 2008
  2. ncbi Antiemetics: American Society of Clinical Oncology clinical practice guideline update
    Ethan Basch
    Memorial Sloan Kettering Cancer Center, New York, USA
    J Clin Oncol 29:4189-98. 2011
    ..To update the American Society of Clinical Oncology (ASCO) guideline for antiemetics in oncology...
  3. ncbi Pharmacological mechanisms of 5-HT₃ and tachykinin NK₁ receptor antagonism to prevent chemotherapy-induced nausea and vomiting
    Camilo Rojas
    Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6515, USA
    Eur J Pharmacol 684:1-7. 2012
    Nausea and vomiting are among the most common and distressing consequences of cytotoxic chemotherapies. Nausea and vomiting can be acute (0-24h) or delayed (24-72 h) after chemotherapy administration...
  4. ncbi Update and new trends in antiemetic therapy: the continuing need for novel therapies
    P Feyer
    Department of Radiooncology, Nuclear Medicine, Vivantes Clinics Berlin Neukölln, Berlin
    Ann Oncol 22:30-8. 2011
    Chemotherapy-induced nausea and vomiting (CINV) continues to be one of the most feared side effects of chemotherapy...
  5. ncbi Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist: results of a phase III, single-dose trial versus dolasetron
    Peter Eisenberg
    California Cancer Care, Greenbrae, California, USA
    Cancer 98:2473-82. 2003
    ..approximately 40 hours), has shown efficacy in Phase II trials in preventing chemotherapy-induced nausea and vomiting (CINV) resulting from highly emetogenic chemotherapy...
  6. ncbi Risk of functional gastrointestinal disorders in U.S. military following self-reported diarrhea and vomiting during deployment
    Chad K Porter
    Enteric Diseases Department, Infectious Disease Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Dig Dis Sci 56:3262-9. 2011
    ..Furthermore, stress associated with deployment may potentiate the increased FGD risk...
  7. ncbi Spectrum of use and tolerability of 5-HT3 receptor antagonists
    U Haus
    Novartis Pharma GmbH, Nuremberg, Germany
    Scand J Rheumatol Suppl 119:12-8. 2004
    ..in the prevention and treatment of chemotherapy-induced nausea and emesis, and in postoperative nausea and vomiting (PONV)...
  8. ncbi Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with cisplatin therapy: randomized, double-blind study protocol--EASE
    Steven Grunberg
    University of Vermont, Dept of Medicine, Fletcher Allen Health Care, 89 Beaumont Ave, Given Bldg E 214, Burlington, VT 05405, USA
    J Clin Oncol 29:1495-501. 2011
    ..NK1RA), to an ondansetron and dexamethasone regimen improves prevention of chemotherapy-induced nausea/vomiting (CINV), particularly during the delayed phase (DP; 25 to 120 hours)...
  9. ncbi Susceptibility to winter vomiting disease: a sweet matter
    Gustaf E Rydell
    Dept of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Rev Med Virol 21:370-82. 2011
    Norovirus, the cause of winter vomiting disease, has emerged in recent years to be a major cause of sporadic and epidemic gastroenteritis worldwide...
  10. pmc Neuromyelitis optica unique area postrema lesions: nausea, vomiting, and pathogenic implications
    B F Gh Popescu
    Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Neurology 76:1229-37. 2011
    ..Aquaporin-4 (AQP4) autoimmunity targets this region, resulting in intractable nausea associated with vomiting or hiccups in NMO.
  11. ncbi Vomiting calls to NHS Direct provide an early warning of norovirus outbreaks in hospitals
    P Loveridge
    Real time Syndromic Surveillance Team, Health Protection Agency West Midlands, Birmingham, UK
    J Hosp Infect 74:385-93. 2010
    ..We investigated whether NHS Direct vomiting calls can be used as a reliable indicator of norovirus activity and, if so, whether the increase in calls ..
  12. ncbi Food protein-induced enterocolitis syndrome: an update on natural history and review of management
    Stephanie A Leonard
    Jaffe Food Allergy Institute, Division of Pediatric Allergy and Immunology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann Allergy Asthma Immunol 107:95-101; quiz 101, 162. 2011
    ..To review the clinical features, pathophysiology, and management of food protein-induced enterocolitis syndrome (FPIES) and to discuss new observations in epidemiology and natural history...
  13. ncbi Review article: cyclic vomiting syndrome in adults--rediscovering and redefining an old entity
    R A Hejazi
    Department of Internal Medicine, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    Aliment Pharmacol Ther 34:263-73. 2011
    Cyclic vomiting syndrome is a disorder characterised by recurrent episodes of severe nausea and vomiting separated by symptom-free periods.
  14. ncbi Acute effect of palonosetron on electrocardiographic parameters in cancer patients: a prospective study
    C Yavas
    Department of Radiation Oncology, Konya Training and Research Hospital, Konya, Turkey
    Support Care Cancer 20:2343-7. 2012
    ..HT(3) receptor antagonists regarding the prevention of acute, delayed and overall chemotherapy-induced nausea and vomiting. First generation 5 HT(3) receptor antagonists may induce electrocardiographic changes of heart rate and ..
  15. ncbi Communicating about chemotherapy-induced nausea and vomiting: a comparison of patient and provider perspectives
    John M Salsman
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Natl Compr Canc Netw 10:149-57. 2012
    Despite recent progress, chemotherapy-induced nausea and vomiting (CINV), especially delayed CINV, continues to be a problem. Delayed CINV is underestimated and perceived differently by providers and patients...
  16. ncbi The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): the Pan European Emesis Registry (PEER)
    M Aapro
    Medical Oncology and Radiation, IMO Clinique de Genolier, Genolier, Switzerland
    Ann Oncol 23:1986-92. 2012
    While guidelines for preventing chemotherapy-induced nausea and vomiting (CINV) are widely available, clinical uptake of guidelines remains low...
  17. ncbi Malnutrition and chemotherapy-induced nausea and vomiting: implications for practice
    Wendy Davidson
    Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Australia
    Oncol Nurs Forum 39:E340-5. 2012
    To determine the prevalence of malnutrition and chemotherapy-induced nausea and vomiting (CINV) limiting patients' dietary intake in a chemotherapy unit.
  18. ncbi Neurokinin-1 receptor antagonists for chemotherapy-induced nausea and vomiting: a systematic review
    Lucas Vieira dos Santos
    Medical Oncology Department, Gastrointestinal Oncology Division, Barretos Cancer Hospital, 520 Brasil St, Barretos, Sao Paulo 14784 011, Brazil
    J Natl Cancer Inst 104:1280-92. 2012
    ..of neurokinin-1 receptor (NK1R) antagonists to antiemetic regimens has substantially reduced chemotherapy-induced nausea and vomiting (CINV). We sought to systematically review the overall impact of NK1R antagonists on CINV prevention.
  19. pmc Palonosetron in combination with 1-day versus 3-day dexamethasone for prevention of nausea and vomiting following moderately emetogenic chemotherapy: a randomized, multicenter, phase III trial
    Luigi Celio
    Medical Oncology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy
    Support Care Cancer 19:1217-25. 2011
    ..III trial assessed the efficacy of palonosetron plus dexamethasone given once in preventing acute and delayed chemotherapy-induced nausea and vomiting (CINV) following a broad range of moderately emetogenic chemotherapy (MEC) regimens.
  20. pmc Efficacy of oral palonosetron compared to intravenous palonosetron for the prevention of chemotherapy-induced nausea and vomiting associated with moderately emetogenic chemotherapy: a phase 3 trial
    Ralph Boccia
    Center for Cancer and Blood Disorders, Bethesda, MD 20817, USA
    Support Care Cancer 21:1453-60. 2013
    ..unique 5-HT3 receptor antagonist (RA) approved as a single IV injection for the prevention of nausea and vomiting induced by chemotherapy (CINV) of either moderate or highly emetogenic potential (MEC and HEC, respectively)...
  21. ncbi Management of platinum-based chemotherapy-induced acute nausea and vomiting: is there a superior serotonin receptor antagonist?
    Mehdi Hamadani
    Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43228, US
    J Oncol Pharm Pract 13:69-75. 2007
    ..5-HT(3))antagonists in revolutionizing the management of platinum-based chemotherapy-induced acute nausea and vomiting (CINV)...
  22. ncbi Drug insight: New antiemetics in the management of chemotherapy-induced nausea and vomiting
    Thein H Oo
    Caritas St Elizabeth s Medical Center and Tufts University School of Medicine, Boston, MA 02135, USA
    Nat Clin Pract Oncol 2:196-201. 2005
    Nausea and vomiting remain among the most feared side effects of chemotherapy for cancer patients...
  23. ncbi Improving the care of patients with regard to chemotherapy-induced nausea and emesis: the effect of feedback to clinicians on adherence to antiemetic prescribing guidelines
    Wilson C Mertens
    Baystate Regional Cancer Program, Division of Hematology Oncology, Baystate Medical Center, Springfield, MA 01107, USA
    J Clin Oncol 21:1373-8. 2003
    ..To evaluate the effect of performance and outcomes feedback on adherence to clinical practice guidelines regarding chemotherapy-induced nausea and emesis (CINE)...
  24. ncbi Cancer chemotherapy-induced nausea and vomiting: role of mediators, development of drugs and treatment methods
    R Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, India
    Pharmazie 60:83-96. 2005
    ..of serotonin 5-HT3 receptor antagonists dramatically improved the treatment of chemotherapy-induced nausea and vomiting. Ondansetron, a serotonin 5-HT3 receptor antagonist in combination with dexamethasone is widely used to treat ..
  25. ncbi Palonosetron: in the prevention of nausea and vomiting
    Lily P H Yang
    Adis, North Shore, Auckland, New Zealand
    Drugs 69:2257-78. 2009
    ..Intravenous palonosetron is widely indicated for the prevention of chemotherapy-induced nausea and vomiting (CINV) in the acute and delayed phases following moderately emetogenic chemotherapy (MEC) and the prevention of ..
  26. pmc Opportunities for the replacement of animals in the study of nausea and vomiting
    A M Holmes
    National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, W1B 1AL, UK
    Br J Pharmacol 157:865-80. 2009
    Nausea and vomiting are among the most common symptoms encountered in medicine as either symptoms of disease or side effects of treatments...
  27. ncbi A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone injection for the prevention of acute chemotherapy-induced nausea and vomiting
    Ching Liang Ho
    Division of Hematology Oncology, Tri Service General Hospital, Taipei, Taiwan
    Jpn J Clin Oncol 40:294-301. 2010
    To evaluate the efficacy of intravenous ramosetron plus dexamethasone for the prevention of acute chemotherapy-induced nausea and vomiting.
  28. ncbi Food protein-induced enterocolitis syndrome: case presentations and management lessons
    Scott H Sicherer
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Allergy Clin Immunol 115:149-56. 2005
    ..Approximately 2 hours after reintroduction of the protein, vomiting ensues, followed by an elevation of the peripheral blood polymorphonuclear leukocyte count, diarrhea, and ..
  29. ncbi Intractable vomiting as the initial presentation of neuromyelitis optica
    Metha Apiwattanakul
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 68:757-61. 2010
    ..Clinic patients identified since 2005) whose initial presenting symptom of neuromyelitis optica was intractable vomiting. The initial evaluation in 75% was gastroenterologic...
  30. ncbi The burden of illness of severe nausea and vomiting of pregnancy in the United States
    Cheryl L Attard
    Innovus Research Inc, Ontario, Canada
    Am J Obstet Gynecol 186:S220-7. 2002
    Our purpose was to determine the extent to which nausea and vomiting of pregnancy affects a woman's quality of life (QOL), ability to function, and health care resource use...
  31. ncbi Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial
    Mitsue Saito
    Department of Breast Oncology, Juntendo University Hospital, Tokyo, Japan
    Lancet Oncol 10:115-24. 2009
    ..that has shown better efficacy than ondansetron and dolasetron in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately emetogenic chemotherapy, and similar efficacy to ondansetron in ..
  32. ncbi Double-blind, randomised, controlled study of the efficacy and tolerability of palonosetron plus dexamethasone for 1 day with or without dexamethasone on days 2 and 3 in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy
    M Aapro
    Division of Oncology, Institut Multidisciplinaire d Oncologie, Clinique de Genolier, Genolier, Switzerland
    Ann Oncol 21:1083-8. 2010
    ..We evaluated the possibility to reduce the total dose of corticosteroids when palonosetron, a long-acting second-generation 5-hydroxytryptamine-3 (5-HT(3)) receptor antagonist, is used...
  33. ncbi Efficacy, dose-response, and safety of ondansetron in prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized placebo-controlled trials
    M R Tramer
    Nuffield Department of Anaesthetics, The Churchill, and Oxford Radcliffe Hospital, United Kingdom
    Anesthesiology 87:1277-89. 1997
    The authors reviewed efficacy and safety data for ondansetron for preventing postoperative nausea and vomiting (PONV).
  34. pmc Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study
    Richard G Boles
    Division of Medical Genetics and the Saban Research Institute, Childrens Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, California 90027, USA
    BMC Neurol 10:10. 2010
    Cyclic vomiting syndrome (CVS), which is defined by recurrent stereotypical episodes of nausea and vomiting, is a relatively-common disabling condition that is associated with migraine headache and mitochondrial dysfunction...
  35. pmc Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases
    Paul L R Andrews
    Division of Basic Medical Sciences, St George s University of London, Cranmer Terrace, London, SW 17 0RE, UK
    Auton Neurosci 125:100-15. 2006
    Nausea and vomiting are amongst the most common symptoms encountered in medicine as either symptoms of diseases or side effects of treatments...
  36. pmc Development and psychometric testing of the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS)
    Mariette Bengtsson
    Division of Gastroenterology and Hepatology, Department of Medicine, Malmo University Hospital, Sweden
    BMC Gastroenterol 7:16. 2007
    ..The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS...
  37. ncbi Two common mitochondrial DNA polymorphisms are highly associated with migraine headache and cyclic vomiting syndrome
    E A Zaki
    Division of Medical Genetics, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Cephalalgia 29:719-28. 2009
    ..multifactorial pathogenesis of migraine without aura (MoA, 'common migraine') and the related condition of cyclic vomiting syndrome (CVS)...
  38. ncbi Resource utilization and costs associated with chemotherapy-induced nausea and vomiting (CINV) following highly or moderately emetogenic chemotherapy administered in the US outpatient hospital setting
    Thomas A Burke
    Global Outcomes Research, Oncology, Global Human Health, Merck and Co, Inc, One Merck Drive, WS2E 76, Whitehouse Station, NJ 08889, USA
    Support Care Cancer 19:131-40. 2011
    Chemotherapy-induced nausea and vomiting (CINV), common adverse events of chemotherapy, may be associated with considerable healthcare resource utilization...
  39. ncbi Efficacy of palonosetron (PAL) compared to other serotonin inhibitors (5-HT3R) in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic (MoHE) treatment: systematic review and meta-analysis
    Tobias Engel Ayer Botrel
    Rua Tranquillo Prosperi, 143, Campinas, Sao Paulo, 13084 778, Brazil
    Support Care Cancer 19:823-32. 2011
    ..25 mg with other 5-HT(3)R in patients receiving moderately or highly emetogenic (MoHE) chemotherapy...
  40. ncbi Nausea and vomiting of pregnancy: using the 24-hour Pregnancy-Unique Quantification of Emesis (PUQE-24) scale
    Neda Ebrahimi
    The Motherisk Program, Hospital for Sick Children, Toronto ON, Canada
    J Obstet Gynaecol Can 31:803-7. 2009
    With up to 80% of pregnant women experiencing nausea and vomiting of pregnancy (NVP), it is critical to have a graded scale of its severity as a guide for appropriate treatment...
  41. ncbi Difference in risk factors for postoperative nausea and vomiting
    Michaela Stadler
    Department of Anesthesiology, University Hospital Center of Charleroi, Belgium
    Anesthesiology 98:46-52. 2003
    It is commonly stated that risk factors for postoperative nausea are the same as for vomiting. The authors designed a prospective study to identify and differentiate the risk factors for postoperative nausea and vomiting in various ..
  42. pmc Insight in the prediction of chemotherapy-induced nausea
    Joseph A Roscoe
    James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Support Care Cancer 18:869-76. 2010
    ..To identify risk factors for chemotherapy-related nausea...
  43. pmc The impact of rotavirus gastroenteritis on the family
    T Christopher Mast
    Merck Research Laboratories, North Wales, PA, USA
    BMC Pediatr 9:11. 2009
    ....
  44. pmc Health-related quality of life in women with nausea and vomiting of pregnancy: the importance of psychosocial context
    S Munch
    School of Social Work, Rutgers University, New Brunswick, NJ 08901, USA
    J Perinatol 31:10-20. 2011
    To test whether women with hyperemesis gravidarum (HG) demonstrated lower health-related quality of life (HRQoL) scores compared with those with nausea and vomiting of pregnancy (NVP).
  45. ncbi A re-evaluation of the neurotransmitter basis of chemotherapy-induced immediate and delayed vomiting: evidence from the least shrew
    Nissar A Darmani
    Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USA
    Brain Res 1248:40-58. 2009
    Although the neurotransmitter basis of chemotherapy-induced vomiting (CIV) is thought to be multifactorial, it is generally accepted that acute (immediate) CIV is mainly due to the release of serotonin (5-HT) within the gastrointestinal ..
  46. ncbi Antiemetic guidelines: creating a more practical treatment approach
    Jim M Koeller
    University of Texas Health Science Center at San Antonio, Pharmacotherapy MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Support Care Cancer 10:519-22. 2002
    ..create a simpler, more practical approach to the use of antiemetics in preventing chemotherapy-induced nausea and vomiting. The group's intention was to clarify available guidelines and produce a practical document, based on evidence, ..
  47. ncbi Why "winter" vomiting disease? Seasonality, hydrology, and Norovirus epidemiology in Toronto, Canada
    Amy L Greer
    Child Health Evaluative Sciences, The Research Institute of the Hospital for Sick Children, Toronto, ON, Canada
    Ecohealth 6:192-9. 2009
    ..The seasonality of disease occurrence is sufficiently stereotyped to result in this disease being dubbed "winter vomiting disease." The genesis of this seasonality has been obscure...
  48. pmc The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo
    Camilo Rojas
    the Brain Science Institute, Johns Hopkins University School of Medicine, 855 N Wolfe Street, Suite 270, Baltimore, MD 21205, USA
    J Pharmacol Exp Ther 335:362-8. 2010
    ..is the only 5-HT(3) receptor antagonist approved for the treatment of delayed chemotherapy-induced nausea and vomiting (CINV) in moderately emetogenic chemotherapy...
  49. ncbi Similarities of the neuronal circuit for the induction of fictive vomiting between ferrets and dogs
    Takako Onishi
    Department of Clinical Nutrition, Faculty of Medical Professions, Kawasaki University of Medical Welfare, 288 Matsushima, Kurashiki, Okayama 701 0193, Japan
    Auton Neurosci 136:20-30. 2007
    Previous studies suggested that the following neuronal circuit participates in the induction of vomiting by afferent vagal stimulation in decerebrated paralyzed dogs: (1) afferent fibers of the vagus nerve, (2) neurons of the solitary ..
  50. ncbi Gastrointestinal motor and myoelectric correlates of motion sickness
    I M Lang
    Department of Medicine and Dysphagia Institute, Medical College of Wisconsin, and Surgical Research Service, Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53226, USA
    Am J Physiol 277:G642-52. 1999
    ..Motion sickness was activated by vertical oscillation (VO) at +/-0.5 g and identified as salivation, licking, or vomiting. Vomiting was initiated chemically by UK-14304 (2.5-15 microg/kg iv) or CuSO4 (10-50 mg ig)...
  51. pmc The efficacy of acupressure for symptom management: a systematic review
    Eun Jin Lee
    Central Baptist Hospital, Lexington, Kentucky, USA
    J Pain Symptom Manage 42:589-603. 2011
    ..Acupressure is a noninvasive strategy used to manage various symptoms...
  52. ncbi Delayed nausea and vomiting continue to reduce patients' quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment
    Brigitte Bloechl-Daum
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    J Clin Oncol 24:4472-8. 2006
    Chemotherapy-induced nausea and vomiting (CINV) are major adverse effects of cancer chemotherapy...
  53. ncbi Effects of antioxidant herbs on chemotherapy-induced nausea and vomiting in a rat-pica model
    Sangeeta R Mehendale
    Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Am J Chin Med 32:897-905. 2004
    Nausea and vomiting are significant adverse effects of chemotherapeutic agents like cisplatin, and cause significant patient morbidity...
  54. pmc Chemotherapy-induced nausea and vomiting in daily clinical practice: a community hospital-based study
    Doranne L Hilarius
    Red Cross Hospital, Vondellaan 13, 1942 LE, Beverwijk, The Netherlands
    Support Care Cancer 20:107-17. 2012
    Chemotherapy-induced nausea and vomiting (CINV) are major adverse effects of cancer chemotherapy...
  55. ncbi Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting--randomised clinical study subset data
    J M Wo
    Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY, USA
    Aliment Pharmacol Ther 33:679-88. 2011
    Limited therapeutic options exist for severe gastroparesis, where severe nausea and vomiting can lead to weight loss, dehydration and malnutrition due to inadequate caloric and fluid intake...
  56. ncbi Review of the efficacy of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in a range of tumor types
    Matti S Aapro
    IMO Clinique de Genolier, Genolier, Switzerland
    Cancer Treat Rev 39:113-7. 2013
    ..Since the distribution of risk factors for chemotherapy-induced nausea and vomiting differs across tumor types, it is important to understand the efficacy of antiemetic regimens in multiple patient ..
  57. pmc Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting
    W L Hasler
    University of Michigan, Ann Arbor, Michigan, USA
    Neurogastroenterol Motil 25:427-38, e300-1. 2013
    ..This study related pain to clinical factors in gastroparesis and contrasted pain/discomfort- with nausea/vomiting-predominant disease.
  58. ncbi Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity--state of the art
    Steven M Grunberg
    Division of Hematology Oncology, University of Vermont College of Medicine, 89 Beaumont Avenue, Given Building E214, Burlington, VT 05405, USA
    Support Care Cancer 19:S43-7. 2011
    ..As control of vomiting has improved, attention has shifted to control of nausea, a related but distinct and equally important problem...
  59. pmc Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared with artemether-lumefantrine for uncomplicated malaria
    Darren Creek
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    Am J Trop Med Hyg 83:873-5. 2010
    ..We used data from a randomized control trial in rural Uganda to compare the risk of early vomiting (within one hour of dosing) for children 6-24 months of age randomized to receive DP (n = 240) or AL (n = 228) ..
  60. pmc Efficacy and safety of single-dose fosaprepitant in the prevention of chemotherapy-induced nausea and vomiting in patients receiving high-dose cisplatin: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial
    H Saito
    Department of Respiratory Medicine, Aichi Cancer Center Aichi Hospital, Okazaki, Japan
    Ann Oncol 24:1067-73. 2013
    ..We evaluated the efficacy and safety of single-dose fosaprepitant in combination with intravenous granisetron and dexamethasone...
  61. ncbi Management of chemotherapy-induced nausea and vomiting : focus on newer agents and new uses for older agents
    Rudolph M Navari
    Indiana University School of Medicine, 1234 Notre Dame Avenue, South Bend, IN 46617, USA
    Drugs 73:249-62. 2013
    Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life...
  62. ncbi Single-dose palonosetron and dexamethasone in preventing nausea and vomiting induced by moderately emetogenic chemotherapy in breast and colorectal cancer patients
    Silvia Brugnatelli
    Medical Oncology, Fondazione Foliclinico San Matteo, Pavia, Italy
    Tumori 97:362-6. 2011
    ..5-HT3 receptor antagonist, has been demonstrated to control emesis related to chemotherapy-induced nausea and vomiting (CINV)...
  63. ncbi Chemotherapy-induced nausea and vomiting: clinician and patient perspectives
    Lee S Schwartzberg
    The West Clinic, 100 N Humphreys Boulevard, Memphis, TN 38120, USA
    J Support Oncol 5:5-12. 2007
    Chemotherapy-induced nausea and vomiting (CINV) is a common and serious problem encountered by many patients receiving anticancer therapy. Up to three fourths of all cancer patients experience chemotherapy-related emesis...
  64. ncbi Optimising antiemetic therapy: what are the problems and how can they be overcome?
    Matti Aapro
    Clinique de Genolier, 1272, Genolier, Switzerland
    Curr Med Res Opin 21:885-97. 2005
    ..use of these agents is recommended for the prevention of both chemotherapy- and radiotherapy-induced nausea and vomiting, given with a corticosteroid...
  65. ncbi Aprepitant: a review of its use in the prevention of nausea and vomiting
    Monique P Curran
    Wolters Kluwer Health, Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore 0754, Auckland, New Zealand
    Drugs 69:1853-78. 2009
    ..once daily on days 2 and 3) was effective in the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with single or multiple cycles of highly emetogenic chemotherapy (HEC)...
  66. ncbi Efficacy of tricyclic antidepressant therapy in adults with cyclic vomiting syndrome: a two-year follow-up study
    Reza A Hejazi
    Center for Gastrointestinal Nerve and Muscle Function, Division of Gastroenterology Motility, Department of Medicine, Kansas University Medical Center, Kansas City, KS, USA
    J Clin Gastroenterol 44:18-21. 2010
    ..effects of prolonged tricyclic antidepressants (TCAs) therapy on the frequency and duration of episodes of cyclic vomiting syndrome (CVS) in adults, and the global assessment of clinical improvement and the number of emergency ..
  67. ncbi Differentiating purging and nonpurging bulimia nervosa and binge eating disorder
    Araceli Núñez-Navarro
    Department of Psychiatry, University Hospital of Bellvitge, Feixa Llarga s n, PC 08907 Barcelona, Spain
    Int J Eat Disord 44:488-96. 2011
    ..To explore similarities and differences in clinical and personality variables across three groups: binge eating disorder (BED), bulimia nervosa-purging type (BN-P), and bulimia nervosa-non purging type (BN-NP)...
  68. pmc Impact of nausea and vomiting on quality of life in cancer patients during chemotherapy
    Enzo Ballatori
    Medical Statistics Unit, Dept of Internal Medicine and Public Health, University, P Tommasi 2, L Aquila, Italy
    Health Qual Life Outcomes 1:46. 2003
    It is commonly claimed that the nausea and vomiting accompanying cytotoxic chemotherapy have a negative impact on health-related quality of life...
  69. ncbi Safety evaluation of aprepitant for the prevention of chemotherapy-induced nausea and vomiting
    Christina H Ruhlmann
    Odense University Hospital, Department of Oncology, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Expert Opin Drug Saf 10:449-62. 2011
    ..the only neurokinin (NK(1)) receptor antagonist (RA) approved for prevention of chemotherapy-induced nausea and vomiting (CINV). Aprepitant is co-administered with a 5-HT(3) RA and a corticosteroid...
  70. ncbi Pharmacological management of chemotherapy-induced nausea and vomiting: focus on recent developments
    Rudolph M Navari
    Department of Medicine, Indiana University School of Medicine, South Bend, USA
    Drugs 69:515-33. 2009
    Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life...
  71. ncbi Chemotherapy-induced nausea and vomiting in breast cancer patients: a prospective observational study
    Christopher M Booth
    Toronto Sunnybrook Regional Cancer Centre and Princess Margaret Hospital, Toronto, Canada
    J Support Oncol 5:374-80. 2007
    Despite advances in the prevention and treatment of emesis, nausea and vomiting are still considered by patients to be among the most severe and feared adverse effects of chemotherapy for breast cancer...
  72. ncbi A progress study of 100 cancer patients treated by acupressure for chemotherapy-induced vomiting after failure with the pharmacological approach
    G Gardani
    Department of Radiotherapy and Oncology, San Gerardo Hospital, Monza, Milan, Italy
    Minerva Med 98:665-8. 2007
    ..has been shown that the pharmacological approach is not the only possible strategy in the treatment of nausea and vomiting, since bioenergetic approaches, such as acupressure and acupuncture, may also counteract the onset of vomiting ..
  73. ncbi Chemotherapy-induced nausea and vomiting: which antiemetic for which therapy?
    Lee S Schwartzberg
    The West Clinic, Memphis, TN 38120, USA
    Oncology (Williston Park) 21:946-53; discussion 954, 959, 962 passim. 2007
    Chemotherapy-induced nausea and vomiting (CINV) remains an important and common toxicity of cancer treatment...
  74. ncbi Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting
    P Diemunsch
    Department of Anesthesiology, Hautepierre University Hospital, 1 Avenue Moliere, Strasbourg, France
    Br J Anaesth 103:7-13. 2009
    ..Aprepitant is the first NK1 receptor antagonist approved for use in postoperative nausea and vomiting, but several other compounds are currently being investigated for their potential as antiemetics in the ..
  75. ncbi Determinants of women's decision making on whether to treat nausea and vomiting of pregnancy pharmacologically
    Anne Baggley
    The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Midwifery Womens Health 49:350-4. 2004
    Nausea and vomiting of pregnancy (NVP) affects up to 80% of all women to some degree during their pregnancies...
  76. pmc Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse
    J H Allen
    Department of Medicine, Mt Barker Hospital, South Australia, Australia
    Gut 53:1566-70. 2004
    To explore the association between chronic cannabis abuse and a cyclical vomiting illness that presented in a series of cases in South Australia.
  77. ncbi Aprepitant (EMEND): the role of substance P in nausea and vomiting
    Eric Prommer
    UCLA School of Medicine, Division of Hematology Oncology, Los Angeles, CA 90073, USA
    J Pain Palliat Care Pharmacother 19:31-9. 2005
    ..Aprepitant is indicated for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy in adults...
  78. ncbi Acupuncture to alleviate chemotherapy-induced nausea and vomiting in pediatric oncology - a randomized multicenter crossover pilot trial
    S Gottschling
    Department of Pediatric Hematology and Oncology, Saarland University, Homburg, Germany
    Klin Padiatr 220:365-70. 2008
    ..We report on a multicenter crossover study at 5 tertiary hospitals in Germany...
  79. ncbi Review article: the pathophysiology, differential diagnosis and management of rumination syndrome
    J Tack
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, Leuven, Vlaanderen, Belgium
    Aliment Pharmacol Ther 33:782-8. 2011
    ..It is now well-recognised that rumination syndrome occurs in patients of all ages and cognitive abilities...
  80. ncbi Chemotherapy-induced nausea and vomiting: antiemetic trials that impacted clinical practice
    Michael E Trigg
    Global Medical Affairs, Merck and Co, Inc, North Wales, PA 19454, USA
    J Oncol Pharm Pract 16:233-44. 2010
    to review the scientific evidence related to serotonin and substance P and the clinical impact targeting these two neurotransmitters have had managing chemotherapy-induced nausea and vomiting (CINV).
  81. ncbi Prophylaxis of radiation-induced nausea and vomiting using 5-hydroxytryptamine-3 serotonin receptor antagonists: a systematic review of randomized trials
    Nadia Salvo
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Int J Radiat Oncol Biol Phys 82:408-17. 2012
    To systematically review the effectiveness and safety of 5-hydroxytryptamine-3 receptor antagonists (5-HT3 RAs) compared with other antiemetic medication or placebo for prophylaxis of radiation-induced nausea and vomiting.
  82. ncbi Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    Eur J Cancer 47:1682-91. 2011
    This study investigates whether demographical, disease-related and genetic factors contribute to inter-individual differences in nausea and vomiting among patients receiving opioids for cancer pain.
  83. ncbi Impact on daily functioning and indirect/direct costs associated with chemotherapy-induced nausea and vomiting (CINV) in a U.S. population
    Amin Haiderali
    Global Health Outcomes Oncology, GlaxoSmithKline, 1250 South Collegeville Road, Mail Code UP4110, Collegeville, PA 19426, USA
    Support Care Cancer 19:843-51. 2011
    Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect of chemotherapy, but it may be prevented or mitigated with medications...
  84. ncbi 5-HT3 receptor antagonists for prevention of late acute-onset emesis
    Manuel Constenla
    Complejo Hospitalario de Pontevedra, C Loureiro Crespo, 2, 36001 Pontevedra, Spain
    Ann Pharmacother 38:1683-91. 2004
    To review the currently available literature on the efficacy of the 5-HT(3) receptor antagonists in the prevention of late acute-onset chemotherapy-induced nausea and vomiting (12-24 h after cytotoxic treatment).
  85. ncbi Prevalence of functional gastrointestinal diseases in a cohort of Sri Lankan adolescents: comparison between Rome II and Rome III criteria
    Niranga Manjuri Devanarayana
    Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    J Trop Pediatr 57:34-9. 2011
    ..Prevalence of functional constipation, aerophagia, adolescent rumination syndrome, cyclical vomiting syndrome and non-retentive faecal incontinence were 4.2, 6.3, 4, 0.5 and 0.2%, respectively. Only 58 (13...
  86. ncbi Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults
    P Bytzer
    Department of Medicine, University of Sydney, Nepean Hospital, Clinical Sciences Building, PO Box 63, Penrith, New South Wales 2751, Australia
    Arch Intern Med 161:1989-96. 2001
    ..CONCLUSIONS: Diabetes mellitus is associated with an increased prevalence of upper and lower gastrointestinal symptoms. This effect may be linked to poor glycemic control but not to duration of diabetes or type of treatment...
  87. ncbi Palonosetron
    M Asif A Siddiqui
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 64:1125-32; discussion 1133-4. 2004
    ..5-HT(3) receptor antagonist that has been evaluated for the prevention of chemotherapy-induced nausea and vomiting. black triangle Intravenously administered palonosetron has a linear pharmacokinetic profile, with a long ..
  88. ncbi Antiemetic control: toward a new standard of care for emetogenic chemotherapy
    Rudolph M Navari
    University of Notre Dame, Walther Cancer Research Center, South Bend, IN 46617, USA
    Expert Opin Pharmacother 10:629-44. 2009
    Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life...
  89. ncbi The safety of drugs for the treatment of nausea and vomiting of pregnancy
    Simerpal K Gill
    The Hospital for Sick Children, The Motherisk Program, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Expert Opin Drug Saf 6:685-94. 2007
    Nausea and vomiting of pregnancy (NVP) is the most common medical condition of pregnancy, affecting up to 80% of all pregnancies to some degree...
  90. ncbi Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options
    Frank Porreca
    Department of Pharmacology, University of Arizona, Tuscon, Arizona 85724, USA
    Pain Med 10:654-62. 2009
    Gastrointestinal (GI) side effects such as nausea and vomiting are common following opioid analgesia and represent a significant cause of patient discomfort and treatment dissatisfaction...
  91. ncbi Relation of nausea and vomiting in acute myocardial infarction to location of the infarct
    Eileen E Fuller
    Department of Internal Medicine, Presbyterian Hospital, Dallas, TX, USA
    Am J Cardiol 104:1638-40. 2009
    To determine whether the incidence of nausea and vomiting in patients with acute myocardial infarction (AMI) varies with infarct location, we studied 180 patients who had been admitted to our hospital for ST-segment elevation AMI or AMI ..
  92. ncbi Acupuncture for nausea and vomiting: an update of clinical and experimental studies
    Konrad Streitberger
    Department of Anaesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Auton Neurosci 129:107-17. 2006
    ..this overview is to summarize existing knowledge about the effects of acupuncture-point stimulation on nausea and vomiting. Systematic reviews on postoperative nausea and vomiting, chemotherapy-induced nausea and vomiting, and pregnancy-..
  93. ncbi Guidelines for antiemetic treatment of chemotherapy-induced nausea and vomiting: past, present, and future recommendations
    Karin Jordan
    Department of Internal Medicine IV, Oncology Hematology, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, 06120 Halle Saale, Germany
    Oncologist 12:1143-50. 2007
    Clinicians should be aware that chemotherapy-induced nausea and vomiting (CINV) is still one of the most feared side effects of chemotherapy...
  94. ncbi Clinical inquiries. What is the best treatment for gastroesophageal reflux and vomiting in infants?
    Vanessa McPherson
    Department of Family Medicine, Carolinas HealthCare System, Charlotte, NC, USA
    J Fam Pract 54:372-5. 2005
    The literature on pediatric reflux can be divided into studies addressing clinically apparent reflux (vomiting or regurgitation) and reflux as measured by pH probe or other methods...
  95. ncbi Functional gastroduodenal disorders
    Jan Tack
    Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
    Gastroenterology 130:1466-79. 2006
    ..The third category, nausea and vomiting disorders, comprises chronic idiopathic nausea (frequent bothersome nausea without vomiting), functional vomiting ..
  96. ncbi Nausea, vomiting, and retching: complex problems in palliative care
    V A Rhodes
    Sinclair School of Nursing, University of Missouri, Columbia, MO, USA
    CA Cancer J Clin 51:232-48; quiz 249-52. 2001
    Patients with advanced cancer commonly experience nausea, vomiting, and/or retching (NVR) as a result of the malignant process and its treatment...
  97. ncbi Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy
    P A Fasching
    University Breast Center Franconia, Erlangen University Hospital, Universitaetsstrasse 21 23, Erlangen, Bavaria, Germany
    J Cancer Res Clin Oncol 134:1079-86. 2008
    The aim of this study was to correlate chemotherapy-induced nausea and vomiting (CINV) with commonly occurring single nucleotide polymorphisms (SNP) in the 5-hydroxytryptamine receptor 3 genes (HTR3)...
  98. ncbi Toxicities of the platinum antineoplastic agents
    Maurie Markman
    Department of Hematology Medical Oncology R 35, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, USA
    Expert Opin Drug Saf 2:597-607. 2003
    ..Furthermore, with appropriate dose modifications, the large majority of patients who may benefit from this class of cytotoxic pharmaceutical drugs will be able to complete a planned therapeutic programme...
  99. ncbi Resiniferatoxin antagonizes cisplatin-induced emesis in dogs and ferrets
    Hisashi Yamakuni
    Department of Cancer and Urology, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, Kashima 2 1 6, Yodogawa, Osaka 532 8514, Japan
    Eur J Pharmacol 442:273-8. 2002
    ..These results suggest that resiniferatoxin-related vanilloids may be useful drugs against both acute and delayed emesis induced by cancer chemotherapy...
  100. pmc Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus)
    Bart C De Jonghe
    Monell Chemical Senses Ctr, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 296:R902-11. 2009
    Cancer chemotherapy drugs, such as cisplatin, potently produce nausea and vomiting. Acute effects of these treatments are partly controlled by antiemetic drugs, but the delayed effects (>24 h), especially nausea, are more difficult to ..
  101. ncbi A study of intragastric and intravesicular pressure changes during rest, coughing, weight lifting, retching, and vomiting
    Atif Iqbal
    Department of Surgery, University of Missouri Columbia, One Hospital Drive, Columbia, MO 65212, USA
    Surg Endosc 22:2571-5. 2008
    ..Our objective was to quantify intragastric and intravesicular pressures during activities, through the use of manometry catheters...

Research Grants68

  1. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Rotavirus infections are the major viral cause of acute vomiting and diarrhea in children under 5 years of age...
  2. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..Acupuncture and its potent alternative, electroacupuncture (EA), are accepted treatments for pain, nausea and vomiting. Small trails further suggest that EA can lower elevated blood pressure...
  3. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..of the vigorous complications of diabetic mellitus in clinics and can cause disabling symptoms including nausea, vomiting and weight loss and often leads to delayed or accelerated gastric emptying...
  4. Predictors of Dietary Quality in Low-Income Pregnant Women
    Eileen R Fowles; Fiscal Year: 2010
    ..contextual maternal factors (ethnicity, pre-pregnant BMI, pregnancy-spacing, pregnancy intendedness, nausea and vomiting) to dietary quality;and 2) explore the relationships of dietary quality and selected nutrition biomarkers to ..
  5. Ibuprofen and enteric neural crest precursor migration
    ELLEN MERRICK; Fiscal Year: 2013
    ..The resulting distal bowel aganglionosis leads to a functional obstruction, which causes vomiting, abdominal distension and predisposes to premature death...
  6. Adipose Organ Transplant for Treatment of Maple Syrup Urine Disease
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2012
    ..amp;BCKAs) accumulate in plasma and tissues, leading to progressive neurological damage, cognitive decline, vomiting, seizures, coma, and death. Standard treatment involves intensive nutritional support to lower BCAA intake...
  7. MURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSION
    Abdu F Azad; Fiscal Year: 2013
    ..The illness is accompanied by fever, headache, chills, vomiting, nausea, myalgia, and rash and leads to disseminated multisystem disease...
  8. Non-invasive Ultrasound Elasticity Imaging (UEI) in Crohn's Disease
    Jonathan M Rubin; Fiscal Year: 2010
    ..When Crohn's patients have abdominal pain and vomiting, this indicates severe narrowing of the small intestine...
  9. Pharmaconutrients as Therapies for Critical Illness: Zinc in Severe Sepsis
    Renee D Stapleton; Fiscal Year: 2013
    ..The endpoints are normalization of plasma zinc level and safety and tolerability parameters including vomiting and diarrhea. The results of this study will lead to R01 or U01 applications for future clinical trials...
  10. BDADs for Male Contraception
    John K Amory; Fiscal Year: 2013
    ..male contraceptives, however, because they caused a "disulfiram reaction" characterized by flushing, nausea and vomiting when co-ingested with alcohol...
  11. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..by the Food and Drug Administration (FDA) (Marinol(r) soft gelatin capsules) for the treatment of nausea and vomiting associated with chemotherapy and for appetite stimulation in AIDS patients suffering from the wasting syndrome...
  12. Enteric Virus Calcium Channel Inhibitors
    Joseph M Hyser; Fiscal Year: 2013
    ..Rotaviruses (RV) are the leading cause of childhood viral gastroenteritis, resulting in diarrhea, vomiting and life-threatening dehydratio...
  13. Patient research in eosinophilic gastrointestinal diseases
    Glenn T Furuta; Fiscal Year: 2013
    ..EGIDs are an increasingly recognized group of diseases affecting children and adults characterized by nausea, vomiting, abdominal pain, dysphagia, food impaction and diarrhea that occur in conjunction with intestinal eosinophilia...
  14. Massachusetts Center for Birth Defects Research and Prevention
    Allen A Mitchell; Fiscal Year: 2013
    ..these medications are popular and vascular disruption pathogenesis is poorly understood);3) Drugs for nausea and vomiting of pregnancy and risk of congenital heart defects (If drugs used as a remedy for such a common condition cause ..
  15. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..There are many risks associated with opiate use including respiratory depression, nausea and vomiting, cough suppression, mental clouding, sedation and constipation, and many of these side-effects are particularly ..
  16. Oral Interleukin 11 as a Countermeasure against Radiation Injury to Gut
    Alexander Burnett; Fiscal Year: 2009
    ..At lesser doses, gastrointestinal syndrome predominates and is characterized by nausea, vomiting, and diarrhea...
  17. Mechanism of Medication Overuse Headache and Chronic Migraine Pain
    Frank Porreca; Fiscal Year: 2013
    ..e., nausea, vomiting, photophobia or phonophobia with or without aura)...
  18. Corticotropin-Releasing Factor Action on GI Function
    YVETTE FRANCE TACHE; Fiscal Year: 2012
    ..can initiate and aggravate functional bowel diseases, such as irritable bowel syndrome, dyspepsia and cyclic vomiting syndrome...
  19. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
    ..provided by applicant): This is a pilot clinical trial of carbidopa to treat the disabling attacks of nausea and vomiting suffered by patients with FD (also known as Riley Day syndrome or hereditary sensory and autonomic neuropathy ..
  20. fMRI in Binge Eating Disorder Participants Pre and Post Bariatric Surgery
    Lauren Puma; Fiscal Year: 2013
    ..g., vomiting). Binge foods usually consist of high-palatability foods (HPF), such as ice cream and pizza...
  21. Transdermal Cannabidiol Prodrug Delivery
    Audra L Stinchcomb; Fiscal Year: 2011
    ..Phase II clinical trials for opiate addiction, analgesic effect, inflammation relief (arthritis), and nausea and vomiting treatment, as there is substantial preclinical/clinical data with CBD to justify therapeutic utility for these ..
  22. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2013
    ..that occurs when hypertension during pregnancy develops with neurologic complications, including headache, vomiting, blindness and convulsions...
  23. VESTIBULAR REGULATION OF RESPIRATORY MUSCLE ACTIVITY
    Bill J Yates; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vomiting is a consequence of a stereotyped pattern of co-contractions of the diaphragm and abdominal muscles that generate high intragastric pressures...
  24. Evaluation of Salmonella in Symptomatic and Asymptomatic Pets
    Timothy S Frana; Fiscal Year: 2012
    ..Salmonellosis causes gastrointestinal disease in humans and animals. Symptoms in people include nausea, vomiting, abdominal cramps, diarrhea, fever and headache...
  25. Massachusetts Center for Birth Defects Research and Prevention
    Allen A Mitchell; Fiscal Year: 2013
    ..drugs, important because they are used by more than 20% of pregnant women;7) Drugs for nausea and vomiting of pregnancy, key because of the increasing use of some medications for this pregnancy-specific condition;8) ..
  26. 2/2-Preventing Eating Disorders and Reducing Comorbidity
    DENISE ELLA WILFLEY; Fiscal Year: 2010
    ..g., vomiting and purging)...
  27. Mechanisms of postnatal cutaneous afferent development during inflammation
    Michael P Jankowski; Fiscal Year: 2013
    ..known that current pharmacological treatments for pain have adverse effects in children such as mild nausea or vomiting but also more severe side effects like respiratory depression and even death...
  28. 1/2-Preventing Eating Disorders and Reducing Comorbidity
    CBARR BARR TAYLOR; Fiscal Year: 2010
    ..g., vomiting and purging)...
  29. Glycated CD59 as a novel biomarker of gestational diabetes mellitus
    Jose A Halperin; Fiscal Year: 2013
    ..costly and time-consuming test with poor reproducibility and many times unwanted effects including nausea and vomiting. A simpler, easy to use, patient friendly marker that is also involved in the pathogenesis of diabetes and its ..
  30. Neural mechanism of glucagon-like-peptide-1 receptor-mediated nausea /malaise
    Matthew R Hayes; Fiscal Year: 2013
    ..It is remarkable to note, however, while nausea and/or vomiting are the major adverse events (i.e...
  31. Role of Gata3 in pylorus development
    Ajay Prakash; Fiscal Year: 2013
    ..common postnatal pathology in infants is hypertrophic pyloric stenosis (HPS), which presents with projectile vomiting and inability to feed. In adults, pyloric malfunction can lead to gastro- duodenal reflux...
  32. Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)
    STEPHEN JOHN CUTLER; Fiscal Year: 2013
    ..in the etiology of weight control, the control of the immune system, treatment of cancer, control of nausea and vomiting in patients receiving anti-neoplastic treatment, glaucoma, and the development of sigma receptor agonists in the ..
  33. Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a Fo
    Gregory Scherrer; Fiscal Year: 2011
    ..However, current opioid therapies generate significant side effects (i.e. paradoxical hyperalgesia, drug abuse, vomiting, constipation, respiratory depression, etc) and have limited efficacy for the treatment of certain types of ..
  34. Pathogenesis of Salmonella bacteremia
    Renee M Tsolis; Fiscal Year: 2013
    ..NTS) are associated with gastroenteritis, a localized infection with low mortality manifesting as diarrhea, vomiting and intestinal cramping...
  35. Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a Fo
    Gregory Scherrer; Fiscal Year: 2013
    ..However, current opioid therapies generate significant side effects (i.e. paradoxical hyperalgesia, drug abuse, vomiting, constipation, respiratory depression, etc) and have limited efficacy for the treatment of certain types of ..
  36. A Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia
    PATRICK PURDON; Fiscal Year: 2009
    ..Other frequent side effects of general anesthesia include cardiovascular and respiratory depression, nausea, and vomiting. These instances of anesthesia-related morbidity occur because anesthetic drugs affect the entire central nervous ..
  37. INTERSPECIFIC COMPETITION BETWEEN RICKETTSIAE IN TICKS
    Abdu F Azad; Fiscal Year: 2013
    ..RMSF is characterized by headache, fever, myalgia, nausea and vomiting early in the illness and if untreated it could progress to multi-organ failure and death...
  38. Obstruction-initiated mechanotranscription in colonic smooth muscle cells
    Xuan Zheng Shi; Fiscal Year: 2012
    ..increased thickness of muscle layer (hypertrophy), and are responsible for symptoms such as abdominal bloating, vomiting, abdominal cramps, and constipation, and may lead to intestinal failure...
  39. Development and Validation of a High Risk and Potential Newborn Screening for Inh
    Edwin W Naylor; Fiscal Year: 2013
    ..For example fatty acid oxidation disorder (an IEM) may have generic symptoms like lethargy, vomiting, and liver anomalies, which make it very hard to pinpoint the condition in the newborn...
  40. MULTI-ANALYTE IMMUNOCHROMATOGRAPHIC TEST STRIP FOR BACTERIAL TOXIN DETECTION
    THOMAS W OWEN; Fiscal Year: 2011
    ..Nausea, vomiting, abdominal cramps and diarrhea are common symptoms in many foodborne diseases...
  41. Functional Networks in Migraine
    Todd Schwedt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Migraine attacks are characterized by moderate to severe ain, nausea, vomiting, increased sensitivity to lights, sounds and odors, and cutaneous allodynia...
  42. Brain Mechanisms for Autonomic Outflow and Nausea in Cyclic Vomiting Syndrome
    Vitaly Napadow; Fiscal Year: 2013
    ..Nausea is a particularly debilitating symptom for patients with Cyclic Vomiting Syndrome (CVS, ROME III definition)...
  43. Actuated Fine-Gauge Spinal Needle Insertion to Reduce Dura Damage and PDPH Risk
    MAUREEN L MULVIHILL; Fiscal Year: 2012
    ..many benefits over general anesthesia including decreased blood loss, decreased post-anesthesia nausea and vomiting, and better post-op pain control...
  44. Phase 2 Study of Esophageal String Test in Diagnosing Eosinophilic Esophagitis
    Glenn T Furuta; Fiscal Year: 2013
    ..is an increasingly recognized rare disease of children and adults characterized by symptoms including nausea, vomiting, abdominal pain, dysphagia and food impaction that occur in conjunction with esophageal eosinophilia...
  45. International Conference on Nausea and Vomiting 2013
    Bill J Yates; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nausea and vomiting are common highly aversive experiences for patients with gastrointestinal disease and result in reductions of appetite, qualit of life, and adherence to medications with these side ..
  46. Novel Approaches to Screening for Inflicted Childhood Neurotrauma
    Rachel P Berger; Fiscal Year: 2013
    ..g. vomiting or irritability) are misdiagnosed by a medical professional...
  47. FUNCTIONAL PLASTICITY IN THE MAMMALIAN SPINAL CORD
    Harry G Goshgarian; Fiscal Year: 2013
    ..doses necessary to induce recovery without experiencing significant side effects (nausea, nervousness, vomiting, etc.) which forced them to discontinue drug therapy...
  48. Parent/Health Care Provider Behaviors &Child's Anxiety
    Zeev Kain; Fiscal Year: 2013
    ..the impact of P-TIPS on surgical recovery parameters such as postoperative pain, recovery room stay, nausea and vomiting, emergence delirium and maladaptive behavioral changes;2...
  49. Advancing Science for the Diagnosis and Treatment of Gastroparesis
    Pankaj J Pasricha; Fiscal Year: 2013
    ..of gastric function characterized by delay in gastric emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness, abdominal pain, and malnutrition that may require nutritional support...
  50. Continuation of the NIDDK Gastroparesis Consortium
    Irene Sarosiek; Fiscal Year: 2013
    ..motilityfunction characterized by a delay in gastric emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness, abdominal pain, and malnutrition that may require nutritional support...
  51. Prospective Measurement of Risk Behaviors in Low Literate Mexican American Women
    Karen F Stein; Fiscal Year: 2013
    ..has been reliably linked to eating disordered (ED) behaviors, such as binge eating, fasting and self-induced vomiting, and, recent studies show that high BMI, tobacco and alcohol use are strongly associated with bulimia nervosa and ..
  52. Transcutaneous electroacupuncture for gastroparesis
    Jiande Chen; Fiscal Year: 2010
    ..Common symptoms of gastroparesis include nausea, vomiting, early satiety and abdominal bloating...
  53. Enteric-Coated Oral Beclomethasone Dipropionate in Patients with Acute Enteritis
    CHRISTOPHER JOSEPH SCHABER; Fiscal Year: 2010
    ..and are not replaced, gastrointestinal toxicity develops over the next few days and weeks with chronic diarrhea, vomiting and pain being the major symptoms...
  54. Temple University Gastroparesis Clinical Center
    HENRY PAUL PARKMAN; Fiscal Year: 2013
    ..placebo for the relief of nausea in patients with chronic nausea and vomiting of presumed gastric origin;PBG: pathological basis of gastroparesis, a tissue study from full thickness gastric ..
  55. Gastroparesis Clinical Research Consortium-University of Michigan Clinical Center
    William L Hasler; Fiscal Year: 2013
    ..provided by applicant): Gastroparesis is characterized by delayed gastric emptying in association with nausea, vomiting, fullness, early satiety, and pain that has devastating impacts on quality of life...
  56. Novel Rinse to Treat Oral Candidiasis in Cancer Patients
    Bakul Bhatt; Fiscal Year: 2007
    ..Furthermore, side effects of Fluconazole include nausea, vomiting, abdominal pain, headaches, dizziness, drowsiness, fever, diarrhea, rash and changes in the sense of taste...
  57. eCancer: A technological approach to symptom management from home to practice
    BRIAN DAVID DECKER; Fiscal Year: 2010
    ..Despite pretreatment supportive care regimens for anemia, neutropenia, nausea and vomiting, levels of burden for such symptoms as pain, fatigue, shortness of breath and loss of appetite remain high...
  58. Genotype Analysis for Diagnosis of Urea Cycle Disorders
    Steven Dobrowolski; Fiscal Year: 2005
    ..Clinical presentation includes poor feeding, vomiting, and lethargy symptoms leading to misdiagnosis as sepsis...
  59. Predicting severe post-surgical pain using clinical risk factors
    Christian C Apfel; Fiscal Year: 2012
    ..for pain, like those developed for other conditions with multi-factorial causes such as postoperative nausea and vomiting, cardiovascular diseases, and cancer, could afford clinicians the opportunity to adopt a more proactive and ..
  60. Dissemination of Patient Centered Outcomes in Anesthesia Care
    Richard P Dutton; Fiscal Year: 2013
    ..Complications that affect patient comfort, such as inadequate pain management or perioperative nausea and vomiting, are common and disturbing occurrences...
  61. SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEM
    KATHY LEPARD; Fiscal Year: 2001
    ..Diabetic patients often experience a wide range of GI discomforts including heartburn, nausea, vomiting, diarrhea, constipation, fecal incontinence and abdominal pain...
  62. Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department
    Polly Bijur; Fiscal Year: 2009
    ..period, number and dose of additional analgesics administered by the clinical staff, incidence of nausea, vomiting, and pruritis...
  63. A MULTI-CHANNEL GASTRIC PACER FOR TREATING GASTROPARESIS
    Robert Ross; Fiscal Year: 2004
    ..In gastroparesis, impaired gastric emptying can lead to nausea, vomiting, premature satiety, abdominal pain, abdominal bloating, weight loss, bacterial overgrowth, and obstruction, as ..
  64. Acupuncture to Prevent Postoperative Paralytic lleus
    JOSEPH CHIANG; Fiscal Year: 2004
    ..quality of life status between treatment and control groups in terms of pain, use of opioid analgesics, nausea, vomiting, insomnia, abdominal distention/fullness, activity, and sense of well-being; and 2) compare costs due to extended ..
  65. Novel non-invasive treatment for hypotension during hemodialysis
    Anja Metzger; Fiscal Year: 2007
    ..IDH often causes abdominal pain, nausea, vomiting, muscle cramps, dizziness and fainting, slows or terminates the dialysis run, reduces the quality of dialysis, ..
  66. EFFECT OF GINSENG ON CISPLATIN-INDUCED EMESIS
    Chun Su Yuan; Fiscal Year: 2006
    ..Nausea/vomiting, a significant adverse effect of chemotherapeutic drugs, should be adequately controlled to reduce morbidity and ..
  67. Dual-pulse electrical stimulation for gastroparesis
    Jiande Chen; Fiscal Year: 2004
    ..gastric electrical stimulation (GES) with short pulses (in the order of mu s) improves symptoms of nausea and vomiting, whereas gastric electrical stimulation with long pulses (in the order of ms) improves gastric motility...
  68. CONTROL OF ENTEROTOXIN GENE EXPRESSION IN S AUREUS
    George Stewart; Fiscal Year: 2003
    ..distinct enterotoxins when growing in food and the ingestion of the preformed toxin is responsible for the vomiting and diarrhea symptomology which is the hallmark of staphylococcal food poisoning...