nausea

Summary

Summary: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.

Top Publications

  1. ncbi Antiemetics: American Society of Clinical Oncology clinical practice guideline update
    Ethan Basch
    Memorial Sloan Kettering Cancer Center, New York, USA
    J Clin Oncol 29:4189-98. 2011
  2. ncbi Pharmacological mechanisms of 5-HT₃ and tachykinin NK₁ receptor antagonism to prevent chemotherapy-induced nausea and vomiting
    Camilo Rojas
    Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6515, USA
    Eur J Pharmacol 684:1-7. 2012
  3. ncbi Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    John B Buse
    Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Lancet 374:39-47. 2009
  4. pmc The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide
    Scott E Kanoski
    Department of Psychology, School of Art and Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 62:1916-27. 2012
  5. ncbi Spectrum of use and tolerability of 5-HT3 receptor antagonists
    U Haus
    Novartis Pharma GmbH, Nuremberg, Germany
    Scand J Rheumatol Suppl 119:12-8. 2004
  6. ncbi Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with cisplatin therapy: randomized, double-blind study protocol--EASE
    Steven Grunberg
    University of Vermont, Dept of Medicine, Fletcher Allen Health Care, 89 Beaumont Ave, Given Bldg E 214, Burlington, VT 05405, USA
    J Clin Oncol 29:1495-501. 2011
  7. doi Chemotherapy-induced nausea and vomiting
    Paul J Hesketh
    Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    N Engl J Med 358:2482-94. 2008
  8. pmc Neuromyelitis optica unique area postrema lesions: nausea, vomiting, and pathogenic implications
    B F Gh Popescu
    Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Neurology 76:1229-37. 2011
  9. ncbi Effects of an integrated yoga programme on chemotherapy-induced nausea and emesis in breast cancer patients
    R M Raghavendra
    Department of Life Sciences, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, India
    Eur J Cancer Care (Engl) 16:462-74. 2007
  10. ncbi The burden of illness of severe nausea and vomiting of pregnancy in the United States
    Cheryl L Attard
    Innovus Research Inc, Ontario, Canada
    Am J Obstet Gynecol 186:S220-7. 2002

Research Grants

  1. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2012
  2. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
  3. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
  4. Predictors of Dietary Quality in Low-Income Pregnant Women
    Eileen R Fowles; Fiscal Year: 2010
  5. Improving pain and function in hip fracture
    R Sean Morrison; Fiscal Year: 2013
  6. Developing Novel Dual CRF-R1/Orexin-1 Receptor Antagonists for Tobacco Dependence
    Belew Mekonnen; Fiscal Year: 2011
  7. Mechanisms of Postoperative Ileus
    YVETTE FRANCE TACHE; Fiscal Year: 2012
  8. Compounds to treat Helicobacter pylori infection
    Kenneth Coleman; Fiscal Year: 2013
  9. MURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSION
    Abdu F Azad; Fiscal Year: 2013
  10. Polyvalent siRNA-Gold Nanoparticle Constructs to Eradicate Glioma
    Emily S Day; Fiscal Year: 2012

Detail Information

Publications367 found, 100 shown here

  1. ncbi Antiemetics: American Society of Clinical Oncology clinical practice guideline update
    Ethan Basch
    Memorial Sloan Kettering Cancer Center, New York, USA
    J Clin Oncol 29:4189-98. 2011
    ..To update the American Society of Clinical Oncology (ASCO) guideline for antiemetics in oncology...
  2. ncbi Pharmacological mechanisms of 5-HT₃ and tachykinin NK₁ receptor antagonism to prevent chemotherapy-induced nausea and vomiting
    Camilo Rojas
    Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6515, USA
    Eur J Pharmacol 684:1-7. 2012
    b>Nausea and vomiting are among the most common and distressing consequences of cytotoxic chemotherapies. Nausea and vomiting can be acute (0-24h) or delayed (24-72 h) after chemotherapy administration...
  3. ncbi Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    John B Buse
    Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Lancet 374:39-47. 2009
    ..We compared the efficacy and safety of liraglutide, a human GLP-1 analogue, with exenatide, an exendin-based GLP-1 receptor agonist...
  4. pmc The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide
    Scott E Kanoski
    Department of Psychology, School of Art and Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 62:1916-27. 2012
    ..b>Nausea is the most common adverse side effect reported with these GLP-1R agonists...
  5. ncbi Spectrum of use and tolerability of 5-HT3 receptor antagonists
    U Haus
    Novartis Pharma GmbH, Nuremberg, Germany
    Scand J Rheumatol Suppl 119:12-8. 2004
    ..antagonists are primarily used and found effective in the prevention and treatment of chemotherapy-induced nausea and emesis, and in postoperative nausea and vomiting (PONV)...
  6. ncbi Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with cisplatin therapy: randomized, double-blind study protocol--EASE
    Steven Grunberg
    University of Vermont, Dept of Medicine, Fletcher Allen Health Care, 89 Beaumont Ave, Given Bldg E 214, Burlington, VT 05405, USA
    J Clin Oncol 29:1495-501. 2011
    ..antagonist (NK1RA), to an ondansetron and dexamethasone regimen improves prevention of chemotherapy-induced nausea/vomiting (CINV), particularly during the delayed phase (DP; 25 to 120 hours)...
  7. doi Chemotherapy-induced nausea and vomiting
    Paul J Hesketh
    Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    N Engl J Med 358:2482-94. 2008
  8. pmc Neuromyelitis optica unique area postrema lesions: nausea, vomiting, and pathogenic implications
    B F Gh Popescu
    Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Neurology 76:1229-37. 2011
    ..Aquaporin-4 (AQP4) autoimmunity targets this region, resulting in intractable nausea associated with vomiting or hiccups in NMO.
  9. ncbi Effects of an integrated yoga programme on chemotherapy-induced nausea and emesis in breast cancer patients
    R M Raghavendra
    Department of Life Sciences, Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, India
    Eur J Cancer Care (Engl) 16:462-74. 2007
    This study examined the effect of an integrated yoga programme on chemotherapy-related nausea and emesis in early operable breast cancer outpatients...
  10. ncbi The burden of illness of severe nausea and vomiting of pregnancy in the United States
    Cheryl L Attard
    Innovus Research Inc, Ontario, Canada
    Am J Obstet Gynecol 186:S220-7. 2002
    Our purpose was to determine the extent to which nausea and vomiting of pregnancy affects a woman's quality of life (QOL), ability to function, and health care resource use...
  11. ncbi Acute effect of palonosetron on electrocardiographic parameters in cancer patients: a prospective study
    C Yavas
    Department of Radiation Oncology, Konya Training and Research Hospital, Konya, Turkey
    Support Care Cancer 20:2343-7. 2012
    ..5 HT(3) receptor antagonists regarding the prevention of acute, delayed and overall chemotherapy-induced nausea and vomiting...
  12. ncbi Communicating about chemotherapy-induced nausea and vomiting: a comparison of patient and provider perspectives
    John M Salsman
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Natl Compr Canc Netw 10:149-57. 2012
    Despite recent progress, chemotherapy-induced nausea and vomiting (CINV), especially delayed CINV, continues to be a problem. Delayed CINV is underestimated and perceived differently by providers and patients...
  13. ncbi The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): the Pan European Emesis Registry (PEER)
    M Aapro
    Medical Oncology and Radiation, IMO Clinique de Genolier, Genolier, Switzerland
    Ann Oncol 23:1986-92. 2012
    While guidelines for preventing chemotherapy-induced nausea and vomiting (CINV) are widely available, clinical uptake of guidelines remains low...
  14. pmc The brain circuitry underlying the temporal evolution of nausea in humans
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Cereb Cortex 23:806-13. 2013
    b>Nausea is a universal human experience. It evolves slowly over time, and brain mechanisms underlying this evolution are not well understood...
  15. ncbi Malnutrition and chemotherapy-induced nausea and vomiting: implications for practice
    Wendy Davidson
    Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Australia
    Oncol Nurs Forum 39:E340-5. 2012
    To determine the prevalence of malnutrition and chemotherapy-induced nausea and vomiting (CINV) limiting patients' dietary intake in a chemotherapy unit.
  16. pmc Palonosetron in combination with 1-day versus 3-day dexamethasone for prevention of nausea and vomiting following moderately emetogenic chemotherapy: a randomized, multicenter, phase III trial
    Luigi Celio
    Medical Oncology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy
    Support Care Cancer 19:1217-25. 2011
    ..III trial assessed the efficacy of palonosetron plus dexamethasone given once in preventing acute and delayed chemotherapy-induced nausea and vomiting (CINV) following a broad range of moderately emetogenic chemotherapy (MEC) regimens.
  17. pmc Efficacy of oral palonosetron compared to intravenous palonosetron for the prevention of chemotherapy-induced nausea and vomiting associated with moderately emetogenic chemotherapy: a phase 3 trial
    Ralph Boccia
    Center for Cancer and Blood Disorders, Bethesda, MD 20817, USA
    Support Care Cancer 21:1453-60. 2013
    ..a pharmacologically unique 5-HT3 receptor antagonist (RA) approved as a single IV injection for the prevention of nausea and vomiting induced by chemotherapy (CINV) of either moderate or highly emetogenic potential (MEC and HEC, ..
  18. ncbi Neurokinin-1 receptor antagonists for chemotherapy-induced nausea and vomiting: a systematic review
    Lucas Vieira dos Santos
    Medical Oncology Department, Gastrointestinal Oncology Division, Barretos Cancer Hospital, 520 Brasil St, Barretos, Sao Paulo 14784 011, Brazil
    J Natl Cancer Inst 104:1280-92. 2012
    ..of neurokinin-1 receptor (NK1R) antagonists to antiemetic regimens has substantially reduced chemotherapy-induced nausea and vomiting (CINV). We sought to systematically review the overall impact of NK1R antagonists on CINV prevention.
  19. ncbi Cancer chemotherapy-induced nausea and vomiting: role of mediators, development of drugs and treatment methods
    R Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, India
    Pharmazie 60:83-96. 2005
    The development of serotonin 5-HT3 receptor antagonists dramatically improved the treatment of chemotherapy-induced nausea and vomiting...
  20. ncbi Palonosetron: in the prevention of nausea and vomiting
    Lily P H Yang
    Adis, North Shore, Auckland, New Zealand
    Drugs 69:2257-78. 2009
    ..Intravenous palonosetron is widely indicated for the prevention of chemotherapy-induced nausea and vomiting (CINV) in the acute and delayed phases following moderately emetogenic chemotherapy (MEC) and the ..
  21. ncbi Improving the care of patients with regard to chemotherapy-induced nausea and emesis: the effect of feedback to clinicians on adherence to antiemetic prescribing guidelines
    Wilson C Mertens
    Baystate Regional Cancer Program, Division of Hematology Oncology, Baystate Medical Center, Springfield, MA 01107, USA
    J Clin Oncol 21:1373-8. 2003
    To evaluate the effect of performance and outcomes feedback on adherence to clinical practice guidelines regarding chemotherapy-induced nausea and emesis (CINE).
  22. ncbi Drug insight: New antiemetics in the management of chemotherapy-induced nausea and vomiting
    Thein H Oo
    Caritas St Elizabeth s Medical Center and Tufts University School of Medicine, Boston, MA 02135, USA
    Nat Clin Pract Oncol 2:196-201. 2005
    b>Nausea and vomiting remain among the most feared side effects of chemotherapy for cancer patients...
  23. ncbi Management of platinum-based chemotherapy-induced acute nausea and vomiting: is there a superior serotonin receptor antagonist?
    Mehdi Hamadani
    Arthur G James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43228, US
    J Oncol Pharm Pract 13:69-75. 2007
    ..receptor (5-HT(3))antagonists in revolutionizing the management of platinum-based chemotherapy-induced acute nausea and vomiting (CINV)...
  24. pmc Opportunities for the replacement of animals in the study of nausea and vomiting
    A M Holmes
    National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, W1B 1AL, UK
    Br J Pharmacol 157:865-80. 2009
    b>Nausea and vomiting are among the most common symptoms encountered in medicine as either symptoms of disease or side effects of treatments...
  25. ncbi A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone injection for the prevention of acute chemotherapy-induced nausea and vomiting
    Ching Liang Ho
    Division of Hematology Oncology, Tri Service General Hospital, Taipei, Taiwan
    Jpn J Clin Oncol 40:294-301. 2010
    To evaluate the efficacy of intravenous ramosetron plus dexamethasone for the prevention of acute chemotherapy-induced nausea and vomiting.
  26. ncbi Migraine symptoms: results of a survey of self-reported migraineurs
    S D Silberstein
    Temple University School of Medicine, Philadelphia, PA, USA
    Headache 35:387-96. 1995
    ..Gastrointestinal disturbances including nausea, vomiting, abdominal cramps, or diarrhea are almost universal...
  27. ncbi Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial
    Mitsue Saito
    Department of Breast Oncology, Juntendo University Hospital, Tokyo, Japan
    Lancet Oncol 10:115-24. 2009
    ..antagonist that has shown better efficacy than ondansetron and dolasetron in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately emetogenic chemotherapy, and similar efficacy to ondansetron ..
  28. ncbi Efficacy, dose-response, and safety of ondansetron in prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized placebo-controlled trials
    M R Tramer
    Nuffield Department of Anaesthetics, The Churchill, and Oxford Radcliffe Hospital, United Kingdom
    Anesthesiology 87:1277-89. 1997
    The authors reviewed efficacy and safety data for ondansetron for preventing postoperative nausea and vomiting (PONV).
  29. ncbi Double-blind, randomised, controlled study of the efficacy and tolerability of palonosetron plus dexamethasone for 1 day with or without dexamethasone on days 2 and 3 in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy
    M Aapro
    Division of Oncology, Institut Multidisciplinaire d Oncologie, Clinique de Genolier, Genolier, Switzerland
    Ann Oncol 21:1083-8. 2010
    ..We evaluated the possibility to reduce the total dose of corticosteroids when palonosetron, a long-acting second-generation 5-hydroxytryptamine-3 (5-HT(3)) receptor antagonist, is used...
  30. ncbi Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations
    T Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    J Neurol Neurosurg Psychiatry 79:1075-8. 2008
    Intractable hiccup and nausea (IHN) are unique symptoms in neuromyelitis optica (NMO). Recent studies have strongly suggested that the pathogenesis of NMO is closely associated with anti-aquaporin-4 (AQP4) antibody...
  31. pmc Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases
    Paul L R Andrews
    Division of Basic Medical Sciences, St George s University of London, Cranmer Terrace, London, SW 17 0RE, UK
    Auton Neurosci 125:100-15. 2006
    b>Nausea and vomiting are amongst the most common symptoms encountered in medicine as either symptoms of diseases or side effects of treatments...
  32. pmc Development and psychometric testing of the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS)
    Mariette Bengtsson
    Division of Gastroenterology and Hepatology, Department of Medicine, Malmo University Hospital, Sweden
    BMC Gastroenterol 7:16. 2007
    ..The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS...
  33. pmc Health-related quality of life in women with nausea and vomiting of pregnancy: the importance of psychosocial context
    S Munch
    School of Social Work, Rutgers University, New Brunswick, NJ 08901, USA
    J Perinatol 31:10-20. 2011
    To test whether women with hyperemesis gravidarum (HG) demonstrated lower health-related quality of life (HRQoL) scores compared with those with nausea and vomiting of pregnancy (NVP).
  34. ncbi Resource utilization and costs associated with chemotherapy-induced nausea and vomiting (CINV) following highly or moderately emetogenic chemotherapy administered in the US outpatient hospital setting
    Thomas A Burke
    Global Outcomes Research, Oncology, Global Human Health, Merck and Co, Inc, One Merck Drive, WS2E 76, Whitehouse Station, NJ 08889, USA
    Support Care Cancer 19:131-40. 2011
    Chemotherapy-induced nausea and vomiting (CINV), common adverse events of chemotherapy, may be associated with considerable healthcare resource utilization...
  35. ncbi Delayed nausea and vomiting continue to reduce patients' quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment
    Brigitte Bloechl-Daum
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    J Clin Oncol 24:4472-8. 2006
    Chemotherapy-induced nausea and vomiting (CINV) are major adverse effects of cancer chemotherapy...
  36. ncbi Efficacy of palonosetron (PAL) compared to other serotonin inhibitors (5-HT3R) in preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic (MoHE) treatment: systematic review and meta-analysis
    Tobias Engel Ayer Botrel
    Rua Tranquillo Prosperi, 143, Campinas, Sao Paulo, 13084 778, Brazil
    Support Care Cancer 19:823-32. 2011
    ..25 mg with other 5-HT(3)R in patients receiving moderately or highly emetogenic (MoHE) chemotherapy...
  37. ncbi Nausea and vomiting of pregnancy: using the 24-hour Pregnancy-Unique Quantification of Emesis (PUQE-24) scale
    Neda Ebrahimi
    The Motherisk Program, Hospital for Sick Children, Toronto ON, Canada
    J Obstet Gynaecol Can 31:803-7. 2009
    With up to 80% of pregnant women experiencing nausea and vomiting of pregnancy (NVP), it is critical to have a graded scale of its severity as a guide for appropriate treatment...
  38. pmc Insight in the prediction of chemotherapy-induced nausea
    Joseph A Roscoe
    James P Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Support Care Cancer 18:869-76. 2010
    To identify risk factors for chemotherapy-related nausea.
  39. ncbi Difference in risk factors for postoperative nausea and vomiting
    Michaela Stadler
    Department of Anesthesiology, University Hospital Center of Charleroi, Belgium
    Anesthesiology 98:46-52. 2003
    It is commonly stated that risk factors for postoperative nausea are the same as for vomiting...
  40. ncbi Ginger: an overview
    Brett White
    Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Am Fam Physician 75:1689-91. 2007
    ..Ginger has been shown to be effective for pregnancy-induced and postoperative nausea and vomiting. There is less evidence to support its use for motion sickness or other types of nausea and vomiting...
  41. pmc Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting
    W L Hasler
    University of Michigan, Ann Arbor, Michigan, USA
    Neurogastroenterol Motil 25:427-38, e300-1. 2013
    ..This study related pain to clinical factors in gastroparesis and contrasted pain/discomfort- with nausea/vomiting-predominant disease.
  42. ncbi Recollections and repercussions of the first inhaled cigarette
    Joseph R DiFranza
    Department of Family Medicine and Community Health, University of Massachusetts Medical School, 55 Lake Avenue, Worcester, MA 01655, USA
    Addict Behav 29:261-72. 2004
    ..It has not been determined if a youth's reaction to the first smoking experience is predictive of future nicotine dependence, or whether the impact of the first cigarette can be altered by manipulating levels of tar, nicotine and menthol...
  43. ncbi Effect of a ginger extract on pregnancy-induced nausea: a randomised controlled trial
    Karen E Willetts
    School of Women and Children s Health, University of New South Wales, Royal Hospital for Women, Randwick, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 43:139-44. 2003
    ..To investigate the effect of a ginger extract (EV.EXT35) on the symptoms of morning sickness...
  44. ncbi Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review
    Ewan McNicol
    Department of Anesthesia, New England Medical Center and Tufts University School of Medicine, Boston, MA 02111, USA
    J Pain 4:231-56. 2003
    ..The side effects studied were constipation, pruritus, nausea and vomiting, myoclonus, sedation, respiratory depression, and delirium...
  45. ncbi Effects of antioxidant herbs on chemotherapy-induced nausea and vomiting in a rat-pica model
    Sangeeta R Mehendale
    Tang Center for Herbal Medicine Research, and Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60637, USA
    Am J Chin Med 32:897-905. 2004
    b>Nausea and vomiting are significant adverse effects of chemotherapeutic agents like cisplatin, and cause significant patient morbidity...
  46. ncbi Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting--randomised clinical study subset data
    J M Wo
    Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY, USA
    Aliment Pharmacol Ther 33:679-88. 2011
    Limited therapeutic options exist for severe gastroparesis, where severe nausea and vomiting can lead to weight loss, dehydration and malnutrition due to inadequate caloric and fluid intake...
  47. pmc The efficacy of acupressure for symptom management: a systematic review
    Eun Jin Lee
    Central Baptist Hospital, Lexington, Kentucky, USA
    J Pain Symptom Manage 42:589-603. 2011
    ..Acupressure is a noninvasive strategy used to manage various symptoms...
  48. pmc Chemotherapy-induced nausea and vomiting in daily clinical practice: a community hospital-based study
    Doranne L Hilarius
    Red Cross Hospital, Vondellaan 13, 1942 LE, Beverwijk, The Netherlands
    Support Care Cancer 20:107-17. 2012
    Chemotherapy-induced nausea and vomiting (CINV) are major adverse effects of cancer chemotherapy...
  49. pmc A survey of visually induced symptoms and associated factors in spectators of three dimensional stereoscopic movies
    Angelo G Solimini
    Department of Public Health and Infectious Diseases, Sapienza University of Rome, Piazza Aldo Moro, 5, 00185, Rome, Italy
    BMC Public Health 12:779. 2012
    ..This study aims to (1) quantify the occurrence of visually induced symptoms suffered by the spectators during and after viewing a commercial 3D movie and (2) to assess individual and environmental factors associated to those symptoms...
  50. ncbi Review of the efficacy of aprepitant for the prevention of chemotherapy-induced nausea and vomiting in a range of tumor types
    Matti S Aapro
    IMO Clinique de Genolier, Genolier, Switzerland
    Cancer Treat Rev 39:113-7. 2013
    ..Since the distribution of risk factors for chemotherapy-induced nausea and vomiting differs across tumor types, it is important to understand the efficacy of antiemetic regimens in ..
  51. ncbi Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica
    T Misu
    Department of Neurology, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Neurology 65:1479-82. 2005
    Intractable hiccup and nausea (IHN) was found in eight of 47 cases of relapsing neuromyelitis optica (NMO) (17%) but in none of 130 cases of multiple sclerosis (MS). IHN resolved with methylprednisolone...
  52. ncbi A placebo-controlled trial of exenatide twice-daily added to thiazolidinediones alone or in combination with metformin
    J Liutkus
    Medicine Professional Corporation, Cambridge, Ontario, Canada
    Diabetes Obes Metab 12:1058-65. 2010
    ..To test the hypothesis that glycaemic control with exenatide added to thiazolidinediones (TZDs) with or without metformin was superior to placebo...
  53. ncbi Evaluation of new antiemetic agents and definition of antineoplastic agent emetogenicity--state of the art
    Steven M Grunberg
    Division of Hematology Oncology, University of Vermont College of Medicine, 89 Beaumont Avenue, Given Building E214, Burlington, VT 05405, USA
    Support Care Cancer 19:S43-7. 2011
    ..As control of vomiting has improved, attention has shifted to control of nausea, a related but distinct and equally important problem...
  54. ncbi Single-dose palonosetron and dexamethasone in preventing nausea and vomiting induced by moderately emetogenic chemotherapy in breast and colorectal cancer patients
    Silvia Brugnatelli
    Medical Oncology, Fondazione Foliclinico San Matteo, Pavia, Italy
    Tumori 97:362-6. 2011
    ..5-HT3 receptor antagonist, has been demonstrated to control emesis related to chemotherapy-induced nausea and vomiting (CINV)...
  55. pmc Efficacy and safety of single-dose fosaprepitant in the prevention of chemotherapy-induced nausea and vomiting in patients receiving high-dose cisplatin: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial
    H Saito
    Department of Respiratory Medicine, Aichi Cancer Center Aichi Hospital, Okazaki, Japan
    Ann Oncol 24:1067-73. 2013
    ..We evaluated the efficacy and safety of single-dose fosaprepitant in combination with intravenous granisetron and dexamethasone...
  56. pmc Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists
    M de Boer Dennert
    Department of Medical Oncology, Rotterdam Cancer Institute Daniel den Hoed Kliniek and University Hospital, The Netherlands
    Br J Cancer 76:1055-61. 1997
    ..Vomiting and nausea were found to be the two most distressing side-effects...
  57. pmc Changes in serotonin metabolism in cancer patients: its relationship to nausea and vomiting induced by chemotherapeutic drugs
    L X Cubeddu
    Central University of Venezuela, School of Pharmacy, Caracas
    Br J Cancer 66:198-203. 1992
    ..Dacarbazine (283 +/- 22 mg m-2), another strongly emetogenic agent, induced acute nausea and emesis paralleled by marked increases in the urinary excretion of 5-HIAA...
  58. ncbi Management of chemotherapy-induced nausea and vomiting : focus on newer agents and new uses for older agents
    Rudolph M Navari
    Indiana University School of Medicine, 1234 Notre Dame Avenue, South Bend, IN 46617, USA
    Drugs 73:249-62. 2013
    Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life...
  59. ncbi Chemotherapy-induced nausea and vomiting: clinician and patient perspectives
    Lee S Schwartzberg
    The West Clinic, 100 N Humphreys Boulevard, Memphis, TN 38120, USA
    J Support Oncol 5:5-12. 2007
    Chemotherapy-induced nausea and vomiting (CINV) is a common and serious problem encountered by many patients receiving anticancer therapy. Up to three fourths of all cancer patients experience chemotherapy-related emesis...
  60. ncbi Aprepitant: a review of its use in the prevention of nausea and vomiting
    Monique P Curran
    Wolters Kluwer Health, Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore 0754, Auckland, New Zealand
    Drugs 69:1853-78. 2009
    ..1 then 80 mg once daily on days 2 and 3) was effective in the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with single or multiple cycles of highly emetogenic chemotherapy (HEC)...
  61. ncbi Safety evaluation of aprepitant for the prevention of chemotherapy-induced nausea and vomiting
    Christina H Ruhlmann
    Odense University Hospital, Department of Oncology, Sdr Boulevard 29, DK 5000 Odense C, Denmark
    Expert Opin Drug Saf 10:449-62. 2011
    Aprepitant is the only neurokinin (NK(1)) receptor antagonist (RA) approved for prevention of chemotherapy-induced nausea and vomiting (CINV). Aprepitant is co-administered with a 5-HT(3) RA and a corticosteroid...
  62. ncbi Chemotherapy-induced nausea and vomiting: which antiemetic for which therapy?
    Lee S Schwartzberg
    The West Clinic, Memphis, TN 38120, USA
    Oncology (Williston Park) 21:946-53; discussion 954, 959, 962 passim. 2007
    Chemotherapy-induced nausea and vomiting (CINV) remains an important and common toxicity of cancer treatment...
  63. ncbi Optimising antiemetic therapy: what are the problems and how can they be overcome?
    Matti Aapro
    Clinique de Genolier, 1272, Genolier, Switzerland
    Curr Med Res Opin 21:885-97. 2005
    ..Prophylactic use of these agents is recommended for the prevention of both chemotherapy- and radiotherapy-induced nausea and vomiting, given with a corticosteroid...
  64. ncbi The associations of maternal caffeine consumption and nausea with spontaneous abortion
    W Wen
    Department of Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232-8300, USA
    Epidemiology 12:38-42. 2001
    ..Of the 71 women who did not experience nausea, 29.6% had a spontaneous abortion, compared with 7.2% of 514 women who did experience nausea...
  65. pmc Impact of nausea and vomiting on quality of life in cancer patients during chemotherapy
    Enzo Ballatori
    Medical Statistics Unit, Dept of Internal Medicine and Public Health, University, P Tommasi 2, L Aquila, Italy
    Health Qual Life Outcomes 1:46. 2003
    It is commonly claimed that the nausea and vomiting accompanying cytotoxic chemotherapy have a negative impact on health-related quality of life...
  66. ncbi Multicenter, phase II, placebo-controlled, double-blind, randomized study of aprepitant in Japanese patients receiving high-dose cisplatin
    Toshiaki Takahashi
    Thoracic Oncology Division, Shizuoka Cancer Center, Sunto gun, Shizuoka, Japan
    Cancer Sci 101:2455-61. 2010
    Aprepitant is a new neurokinin-1 (NK(1) ) receptor antagonist developed as a treatment for chemotherapy-induced nausea and vomiting (CINV)...
  67. ncbi Manual acupuncture as an adjunctive treatment of nausea in patients with cancer in palliative care--a prospective, observational pilot study
    Elisabeth Nystrom
    Advanced home healthcare, Solna Sundbyberg, Solna, Sweden
    Acupunct Med 26:27-32. 2008
    ..been reported for the effect of PC6 acupuncture in preventing or attenuating postoperative and pregnancy related nausea. Our primary aim was to examine whether PC6 acupuncture during a period of chemotherapy could complement ..
  68. ncbi Impact on daily functioning and indirect/direct costs associated with chemotherapy-induced nausea and vomiting (CINV) in a U.S. population
    Amin Haiderali
    Global Health Outcomes Oncology, GlaxoSmithKline, 1250 South Collegeville Road, Mail Code UP4110, Collegeville, PA 19426, USA
    Support Care Cancer 19:843-51. 2011
    Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect of chemotherapy, but it may be prevented or mitigated with medications...
  69. ncbi Motion sickness susceptibility questionnaire revised and its relationship to other forms of sickness
    J F Golding
    Department of Psychology, University of Westminster, London, UK
    Brain Res Bull 47:507-16. 1998
    ..45. Correlation between MSSQ and other sources of nausea and vomiting in the last 12 months, excluding motion sickness itself, was r = 0.3 (p < 0...
  70. ncbi Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting
    P Diemunsch
    Department of Anesthesiology, Hautepierre University Hospital, 1 Avenue Moliere, Strasbourg, France
    Br J Anaesth 103:7-13. 2009
    ..Aprepitant is the first NK1 receptor antagonist approved for use in postoperative nausea and vomiting, but several other compounds are currently being investigated for their potential as antiemetics in ..
  71. ncbi Chemotherapy-induced nausea and vomiting: antiemetic trials that impacted clinical practice
    Michael E Trigg
    Global Medical Affairs, Merck and Co, Inc, North Wales, PA 19454, USA
    J Oncol Pharm Pract 16:233-44. 2010
    to review the scientific evidence related to serotonin and substance P and the clinical impact targeting these two neurotransmitters have had managing chemotherapy-induced nausea and vomiting (CINV).
  72. ncbi Prophylaxis of radiation-induced nausea and vomiting using 5-hydroxytryptamine-3 serotonin receptor antagonists: a systematic review of randomized trials
    Nadia Salvo
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
    Int J Radiat Oncol Biol Phys 82:408-17. 2012
    To systematically review the effectiveness and safety of 5-hydroxytryptamine-3 receptor antagonists (5-HT3 RAs) compared with other antiemetic medication or placebo for prophylaxis of radiation-induced nausea and vomiting.
  73. ncbi Treatment of nausea and vomiting in advanced cancer
    M P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    Support Care Cancer 8:444-52. 2000
    b>Nausea and vomiting unrelated to chemotherapy is common in advanced cancer patients. The etiology of nausea and vomiting may from evident by the pattern of vomiting, associated symptoms, review of medications and physical examination...
  74. ncbi Acupuncture to alleviate chemotherapy-induced nausea and vomiting in pediatric oncology - a randomized multicenter crossover pilot trial
    S Gottschling
    Department of Pediatric Hematology and Oncology, Saarland University, Homburg, Germany
    Klin Padiatr 220:365-70. 2008
    ..We report on a multicenter crossover study at 5 tertiary hospitals in Germany...
  75. ncbi Conditioned nausea in rats: assessment by conditioned disgust reactions, rather than conditioned taste avoidance
    Linda A Parker
    Department of Psychology, University of Guelph, uelph, ON
    Can J Exp Psychol 62:198-209. 2008
    ..aversion as conditioned disgust reactions (gapes, chin rubs, and paw treads) during an intraoral infusion of a nausea-paired flavored solution...
  76. ncbi Aprepitant (EMEND): the role of substance P in nausea and vomiting
    Eric Prommer
    UCLA School of Medicine, Division of Hematology Oncology, Los Angeles, CA 90073, USA
    J Pain Palliat Care Pharmacother 19:31-9. 2005
    ..Aprepitant is indicated for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy in adults...
  77. ncbi 5-HT3 receptor antagonists for prevention of late acute-onset emesis
    Manuel Constenla
    Complejo Hospitalario de Pontevedra, C Loureiro Crespo, 2, 36001 Pontevedra, Spain
    Ann Pharmacother 38:1683-91. 2004
    To review the currently available literature on the efficacy of the 5-HT(3) receptor antagonists in the prevention of late acute-onset chemotherapy-induced nausea and vomiting (12-24 h after cytotoxic treatment).
  78. ncbi Acupressure for nausea: results of a pilot study
    S L Dibble
    Institute for Health and Aging, University of California, San Francisco, USA
    Oncol Nurs Forum 27:41-7. 2000
    To compare differences in nausea experience and intensity in women undergoing chemotherapy for breast cancer between those receiving usual care plus acupressure training and treatment and those receiving only usual care.
  79. ncbi Pharmacological management of chemotherapy-induced nausea and vomiting: focus on recent developments
    Rudolph M Navari
    Department of Medicine, Indiana University School of Medicine, South Bend, USA
    Drugs 69:515-33. 2009
    Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life...
  80. ncbi Nausea, pain, fatigue, and multiple symptoms in hospitalized children with cancer
    Elizabeth Miller
    Children s Hospital of Los Angeles, California, USA
    Oncol Nurs Forum 38:E382-93. 2011
    To describe the prevalence, frequency, severity, and distress of multiple symptoms in hospitalized children with cancer and to examine the overall symptom scores and global distress in patients reporting nausea, pain, and fatigue.
  81. ncbi Patient expectation is a strong predictor of severe nausea after chemotherapy: a University of Rochester Community Clinical Oncology Program study of patients with breast carcinoma
    Joseph A Roscoe
    Behavioral Medicine Unit, University of Rochester Community Clinical Oncology Program Research Base, University of Rochester James P Wilmot Cancer Center, Rochester, New York
    Cancer 101:2701-8. 2004
    Patients may use their past experiences with nausea, as well as information about the incidence of nausea from chemotherapy that other patients have experienced, to form a prediction, or response expectancy, of nausea from their own ..
  82. ncbi Determinants of women's decision making on whether to treat nausea and vomiting of pregnancy pharmacologically
    Anne Baggley
    The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Midwifery Womens Health 49:350-4. 2004
    b>Nausea and vomiting of pregnancy (NVP) affects up to 80% of all women to some degree during their pregnancies...
  83. ncbi Palonosetron: a second-generation 5-hydroxytryptamine receptor antagonist
    Rudolph M Navari
    Indiana University School of Medicine, Notre Dame Cancer Institute, South Bend, IN 46617, USA
    Future Oncol 2:591-602. 2006
    Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life...
  84. ncbi Conditioned food aversion in Suncus murinus (house musk shrew) - a new model for the study of nausea in a species with an emetic reflex
    J E Smith
    Department of Physiology, St. George's Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK
    Physiol Behav 73:593-8. 2001
    ..murinus and that the induction of emesis can be uncoupled from food aversion. S. murinus provides a promising new model in which the relationship between emesis, nausea and conditioned food aversion can be investigated.
  85. ncbi Chemotherapy-induced nausea and vomiting in breast cancer patients: a prospective observational study
    Christopher M Booth
    Toronto Sunnybrook Regional Cancer Centre and Princess Margaret Hospital, Toronto, Canada
    J Support Oncol 5:374-80. 2007
    Despite advances in the prevention and treatment of emesis, nausea and vomiting are still considered by patients to be among the most severe and feared adverse effects of chemotherapy for breast cancer...
  86. ncbi Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    Eur J Cancer 47:1682-91. 2011
    This study investigates whether demographical, disease-related and genetic factors contribute to inter-individual differences in nausea and vomiting among patients receiving opioids for cancer pain.
  87. ncbi Update and new trends in antiemetic therapy: the continuing need for novel therapies
    P Feyer
    Department of Radiooncology, Nuclear Medicine, Vivantes Clinics Berlin Neukölln, Berlin
    Ann Oncol 22:30-8. 2011
    Chemotherapy-induced nausea and vomiting (CINV) continues to be one of the most feared side effects of chemotherapy...
  88. ncbi Acupuncture for nausea and vomiting: an update of clinical and experimental studies
    Konrad Streitberger
    Department of Anaesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Auton Neurosci 129:107-17. 2006
    ..of this overview is to summarize existing knowledge about the effects of acupuncture-point stimulation on nausea and vomiting...
  89. ncbi Palonosetron
    M Asif A Siddiqui
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 64:1125-32; discussion 1133-4. 2004
    ..selective serotonin 5-HT(3) receptor antagonist that has been evaluated for the prevention of chemotherapy-induced nausea and vomiting...
  90. ncbi Guidelines for antiemetic treatment of chemotherapy-induced nausea and vomiting: past, present, and future recommendations
    Karin Jordan
    Department of Internal Medicine IV, Oncology Hematology, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, 06120 Halle Saale, Germany
    Oncologist 12:1143-50. 2007
    Clinicians should be aware that chemotherapy-induced nausea and vomiting (CINV) is still one of the most feared side effects of chemotherapy...
  91. ncbi Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults
    P Bytzer
    Department of Medicine, University of Sydney, Nepean Hospital, Clinical Sciences Building, PO Box 63, Penrith, New South Wales 2751, Australia
    Arch Intern Med 161:1989-96. 2001
    ..CONCLUSIONS: Diabetes mellitus is associated with an increased prevalence of upper and lower gastrointestinal symptoms. This effect may be linked to poor glycemic control but not to duration of diabetes or type of treatment...
  92. ncbi The safety of drugs for the treatment of nausea and vomiting of pregnancy
    Simerpal K Gill
    The Hospital for Sick Children, The Motherisk Program, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Expert Opin Drug Saf 6:685-94. 2007
    b>Nausea and vomiting of pregnancy (NVP) is the most common medical condition of pregnancy, affecting up to 80% of all pregnancies to some degree...
  93. ncbi Antiemetic control: toward a new standard of care for emetogenic chemotherapy
    Rudolph M Navari
    University of Notre Dame, Walther Cancer Research Center, South Bend, IN 46617, USA
    Expert Opin Pharmacother 10:629-44. 2009
    Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life...
  94. ncbi Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options
    Frank Porreca
    Department of Pharmacology, University of Arizona, Tuscon, Arizona 85724, USA
    Pain Med 10:654-62. 2009
    Gastrointestinal (GI) side effects such as nausea and vomiting are common following opioid analgesia and represent a significant cause of patient discomfort and treatment dissatisfaction...
  95. pmc Capecitabine plus Irinotecan (XELIRI regimen) compared to 5-FU/LV plus Irinotecan (FOLFIRI regimen) as neoadjuvant treatment for patients with unresectable liver-only metastases of metastatic colorectal cancer: a randomised prospective phase II trial
    Erik Skof
    Institute of Oncology, Division of Medical Oncology, Zaloska 2, 1000 Ljubljana, Slovenia
    BMC Cancer 9:120. 2009
    ..There are, however, no data about the use of the XELIRI regimen in the neoadjuvant treatment...
  96. ncbi Relation of nausea and vomiting in acute myocardial infarction to location of the infarct
    Eileen E Fuller
    Department of Internal Medicine, Presbyterian Hospital, Dallas, TX, USA
    Am J Cardiol 104:1638-40. 2009
    To determine whether the incidence of nausea and vomiting in patients with acute myocardial infarction (AMI) varies with infarct location, we studied 180 patients who had been admitted to our hospital for ST-segment elevation AMI or AMI ..
  97. ncbi Clinically significant changes in nausea as measured on a visual analog scale
    Gregory W Hendey
    University of California, San Francisco Fresno, University Medical Center, Fresno, CA 93702, USA
    Ann Emerg Med 45:77-81. 2005
    Our objective is to determine the minimum clinically significant change in nausea as measured on a visual analog scale.
  98. ncbi Undertreatment of nausea and other symptoms in hospitalized cancer patients
    Judi Greaves
    Palliative Care, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC 3002, Australia
    Support Care Cancer 17:461-4. 2009
    This survey aimed to provide a symptom profile, in particular for nausea and its treatment, of advanced cancer patients prior to implementation of a clinical practice guideline for nausea.
  99. ncbi Nausea, vomiting, and retching: complex problems in palliative care
    V A Rhodes
    Sinclair School of Nursing, University of Missouri, Columbia, MO, USA
    CA Cancer J Clin 51:232-48; quiz 249-52. 2001
    Patients with advanced cancer commonly experience nausea, vomiting, and/or retching (NVR) as a result of the malignant process and its treatment...
  100. ncbi Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy
    P A Fasching
    University Breast Center Franconia, Erlangen University Hospital, Universitaetsstrasse 21 23, Erlangen, Bavaria, Germany
    J Cancer Res Clin Oncol 134:1079-86. 2008
    The aim of this study was to correlate chemotherapy-induced nausea and vomiting (CINV) with commonly occurring single nucleotide polymorphisms (SNP) in the 5-hydroxytryptamine receptor 3 genes (HTR3)...
  101. ncbi Aprepitant: a review of its use in the prevention of chemotherapy-induced nausea and vomiting
    Toni M Dando
    Adis International Limited, 41 Centorian Drive, PB 65901, Mairangi Bay, Auckland, New Zealand
    Drugs 64:777-94. 2004
    ..in combination with other agents, is indicated for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy in adults...

Research Grants74

  1. Alzheimer's Disease Therapeutic
    Trevor P Castor; Fiscal Year: 2012
    ..which contains oil soluble gingerols and shogaols, recently completed a successful Phase II/III clinical trial for nausea and emesis in cancer patients undergoing chemotherapy...
  2. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..by applicant): Acupuncture and its potent alternative, electroacupuncture (EA), are accepted treatments for pain, nausea and vomiting. Small trails further suggest that EA can lower elevated blood pressure...
  3. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..is one of the vigorous complications of diabetic mellitus in clinics and can cause disabling symptoms including nausea, vomiting and weight loss and often leads to delayed or accelerated gastric emptying...
  4. Predictors of Dietary Quality in Low-Income Pregnant Women
    Eileen R Fowles; Fiscal Year: 2010
    ..habits) and contextual maternal factors (ethnicity, pre-pregnant BMI, pregnancy-spacing, pregnancy intendedness, nausea and vomiting) to dietary quality;and 2) explore the relationships of dietary quality and selected nutrition ..
  5. Improving pain and function in hip fracture
    R Sean Morrison; Fiscal Year: 2013
    ..g., constipation, delirium, sedation, nausea, respiratory depression) and studies suggest that older adults receive significantly less analgesia than younger ..
  6. Developing Novel Dual CRF-R1/Orexin-1 Receptor Antagonists for Tobacco Dependence
    Belew Mekonnen; Fiscal Year: 2011
    ..satisfactory, and is further confounded by serious unwanted side effects such as insomnia, dry mouth, seizure, nausea, headache, psychotropic and gastrointestinal upset...
  7. Mechanisms of Postoperative Ileus
    YVETTE FRANCE TACHE; Fiscal Year: 2012
    ..Besides causing significant discomfort to patients (bloating, nausea, emesis, and abdominal pain), POI hampers recovery and constitutes the most common reason for delaying discharge ..
  8. Compounds to treat Helicobacter pylori infection
    Kenneth Coleman; Fiscal Year: 2013
    ..will not harm the intestinal flora, avoiding many of the common side effects of broad spectrum antibiotics such as nausea and diarrhea. This provides preliminary validation for the approach to develop specific therapeutics targeting H...
  9. MURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSION
    Abdu F Azad; Fiscal Year: 2013
    ..The illness is accompanied by fever, headache, chills, vomiting, nausea, myalgia, and rash and leads to disseminated multisystem disease...
  10. Polyvalent siRNA-Gold Nanoparticle Constructs to Eradicate Glioma
    Emily S Day; Fiscal Year: 2012
    ..are also viable treatment options, but they are plagued by side effects ranging from minor reactions like nausea and hair loss to extreme complications such as personality changes, loss of physical ability, or cognitive ..
  11. A Prospective Cohort Study of Migraines, Platelet Activation, and Preeclampsia
    Michelle A Williams; Fiscal Year: 2012
    ..from tension-type headaches by the moderate to severe intensity, unilateral location, the presence of nausea, and sensitivity to activity and/or stimuli...
  12. Enhancing neutrophil function in neutropenia-related pneumonia
    Hongbo R Luo; Fiscal Year: 2012
    ..antibiotic treatment and G-CSF therapy is often associated with side-effects such as bone pain, headache, fatigue, nausea, and higher risk of getting leukemia...
  13. Searching for Novel Analgesic and Anti-inflammatory Agents
    Guigen Li; Fiscal Year: 2010
    ..proven to show physiological effects, such as supraspinal analgesia, respiratory depression, miosis, euphoria, nausea, and reduced gastrointestinal motility...
  14. BDADs for Male Contraception
    John K Amory; Fiscal Year: 2013
    ..to market as male contraceptives, however, because they caused a "disulfiram reaction" characterized by flushing, nausea and vomiting when co-ingested with alcohol...
  15. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..been approved by the Food and Drug Administration (FDA) (Marinol(r) soft gelatin capsules) for the treatment of nausea and vomiting associated with chemotherapy and for appetite stimulation in AIDS patients suffering from the wasting ..
  16. Patient research in eosinophilic gastrointestinal diseases
    Glenn T Furuta; Fiscal Year: 2013
    ..The Disease- EGIDs are an increasingly recognized group of diseases affecting children and adults characterized by nausea, vomiting, abdominal pain, dysphagia, food impaction and diarrhea that occur in conjunction with intestinal ..
  17. Taste and Cyclophosphamide in Mice
    Eugene R Delay; Fiscal Year: 2013
    ..Prior research has focused mostly on how nausea and other side effects of these drugs form conditioned food aversions that reduce food consumption, or how these ..
  18. Phase 1 of AR-42 in relapsed CLL, lymphoma, myeloma
    Craig C Hofmeister; Fiscal Year: 2012
    ..levels and unconfirmed responses have been observed in myeloma patients as a single agent without the fatigue and nausea characteristic of other class I/II DAC inhibitors...
  19. Mechanisms of Cardiac Function and Cerebral Vascular Control during Heat Stress
    Robert Matthew Brothers; Fiscal Year: 2010
    ..in this condition to have compromised blood pressure control evidenced by lightheadedness, vertigo, and nausea upon standing or similar gravitational stressors, which can lead to syncope and a high potential of injury...
  20. Massachusetts Center for Birth Defects Research and Prevention
    Allen A Mitchell; Fiscal Year: 2013
    ..because these medications are popular and vascular disruption pathogenesis is poorly understood);3) Drugs for nausea and vomiting of pregnancy and risk of congenital heart defects (If drugs used as a remedy for such a common ..
  21. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..There are many risks associated with opiate use including respiratory depression, nausea and vomiting, cough suppression, mental clouding, sedation and constipation, and many of these side-effects are ..
  22. Oral Interleukin 11 as a Countermeasure against Radiation Injury to Gut
    Alexander Burnett; Fiscal Year: 2009
    ..At lesser doses, gastrointestinal syndrome predominates and is characterized by nausea, vomiting, and diarrhea...
  23. Protease Operated Depot for Delivery of GLP-1
    Ashutosh Chilkoti; Fiscal Year: 2013
    ..which necessitates twice-daily injection of the drug, and also leads to undesirable side-reactions such as nausea, and hence limits both the efficacy of the drug and its widespread adoption...
  24. Glial-Neural Interactions in Autonomic Control
    Richard C Rogers; Fiscal Year: 2012
    ..was the 70 year-old observation by Cushing that bleeding intracranial head injury produced a profound anorexia, nausea, gastric stasis, and accompanying ulcer...
  25. Allosteric Modulators of CB1 Cannabinoid Receptor
    GANESHSINGH ARJUNSINGH THAKUR; Fiscal Year: 2010
    ..While generally well tolerated, there was nonetheless a high dropout rate and an increased incidence of nausea and psychiatric disorders associated with rimonabant clinical trials, highlighting the need to develop safer ..
  26. Mechanism of Medication Overuse Headache and Chronic Migraine Pain
    Frank Porreca; Fiscal Year: 2013
    ..e., nausea, vomiting, photophobia or phonophobia with or without aura)...
  27. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This is a pilot clinical trial of carbidopa to treat the disabling attacks of nausea and vomiting suffered by patients with FD (also known as Riley Day syndrome or hereditary sensory and autonomic ..
  28. Chemoprevention of pituitary gonadotrope tumors
    T Rajendra Kumar; Fiscal Year: 2013
    ..as damage to brain tissue and optic chiasm, vision loss, increased intracranial pressure, persistent headache and nausea. Because they have no well-defined diagnostic markers, null cell adenomas often go undetected until they are very ..
  29. Oral paclitaxel solubilized and bioenhanced by food compound for cancer therapy
    Zhijun Liu; Fiscal Year: 2013
    ..g., nausea, hypersensitivity reactions) and significant cost savings...
  30. Transdermal Cannabidiol Prodrug Delivery
    Audra L Stinchcomb; Fiscal Year: 2011
    ..be tested in Phase II clinical trials for opiate addiction, analgesic effect, inflammation relief (arthritis), and nausea and vomiting treatment, as there is substantial preclinical/clinical data with CBD to justify therapeutic utility ..
  31. Design, Synthesis and Evaluation of Novel Isoform-Selective Sodium Channel Inhibi
    JOHN VINCENT MULCAHY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Side effects associated with opioid analgesics, such as nausea, drowsiness, respiratory depression, and potential for addiction, are motivating the design and development of new therapies for acute, ..
  32. Discovering a Combination Therapeutic Approach to Use in the Treatment of Cryptoc
    Mitchell W Mutz; Fiscal Year: 2013
    ..CM presents with symptoms including severe nausea, headache due to inflammation of the meninges, altered mental status, and fever...
  33. In vitro screening of novel therapeutic agents for the treatment of alcohol abuse
    S John Mihic; Fiscal Year: 2010
    ..as an anti-parasitic compound by the Danish company Medicinalco when workers administered it noted symptoms of nausea following alcohol use...
  34. VESTIBULAR REGULATION OF RESPIRATORY MUSCLE ACTIVITY
    Bill J Yates; Fiscal Year: 2013
    ..Specific Aim 1 will map the locations of neurons activated during vomiting and accompanying nausea elicited by stimulation of vestibular receptors and compare the sites to those activated during emesis triggered ..
  35. Evaluation of Salmonella in Symptomatic and Asymptomatic Pets
    Timothy S Frana; Fiscal Year: 2012
    ..Salmonellosis causes gastrointestinal disease in humans and animals. Symptoms in people include nausea, vomiting, abdominal cramps, diarrhea, fever and headache...
  36. Massachusetts Center for Birth Defects Research and Prevention
    Allen A Mitchell; Fiscal Year: 2013
    ..steroidal anti-inflammatory drugs, important because they are used by more than 20% of pregnant women;7) Drugs for nausea and vomiting of pregnancy, key because of the increasing use of some medications for this pregnancy-specific ..
  37. KIDNEY STONE INHIBITORS
    SHANTHA S SARANGAPANI; Fiscal Year: 2013
    ..dosages for these medications are very high and could cause serious side effects, gastrointestinal lesions, nausea and other complications resulting in poor compliance...
  38. Phenotype-Genotype Associations with Symptoms During Childhood Leukemia Treatment
    Michael E Scheurer; Fiscal Year: 2013
    ..Symptoms include fatigue, sleep disturbance, pain, depression, nausea, physical activity changes, as well as memory and cognition deficits...
  39. Engineered Opioid Receptors as Therapeutic Agents for Pain Control
    Ping Yee Law; Fiscal Year: 2012
    ..Unfortunately, their uses have been associated with many troublesome side effects such as nausea, constipation, respiratory depression, sedation, pruritus, tolerance and dependence development...
  40. Mechanisms of postnatal cutaneous afferent development during inflammation
    Michael P Jankowski; Fiscal Year: 2013
    ..it is well known that current pharmacological treatments for pain have adverse effects in children such as mild nausea or vomiting but also more severe side effects like respiratory depression and even death...
  41. Crystallization and structure determination of the mu-opioid receptor
    Roger K Sunahara; Fiscal Year: 2012
    ..of pain, analgesics that work on [unreadable]OR have various adverse and sometimes fatal side-effects including nausea, respiratory depression, addiction, and constipation...
  42. Glycated CD59 as a novel biomarker of gestational diabetes mellitus
    Jose A Halperin; Fiscal Year: 2013
    ..a cumbersome, costly and time-consuming test with poor reproducibility and many times unwanted effects including nausea and vomiting...
  43. Neural mechanism of glucagon-like-peptide-1 receptor-mediated nausea /malaise
    Matthew R Hayes; Fiscal Year: 2013
    ..It is remarkable to note, however, while nausea and/or vomiting are the major adverse events (i.e...
  44. AEROSOL FUROSEMIDE FOR DYSPNEA RELIEF: LABORATORY AND CLINICAL STUDIES
    Robert B Banzett; Fiscal Year: 2013
    ..Opiates carry many disadvantages including depression of respiration, confusion, nausea and constipation...
  45. Treatment of SLE with ajulemic acid, a non-psychoactive cannabinoid derivative
    Meggan Mackay; Fiscal Year: 2013
    ..including gastrointestinal bleeding and kidney toxicity in the case of NSAIDS, somnolence, constipation and nausea for narcotics and osteoporosis, osteonecrosis, diabetes, cataracts and atherosclerosis for corticosteroids...
  46. Biochemical, Structural and Polymorphic Characterization of Human ALDH1B1
    BRIAN CHRISTOPHER JACKSON; Fiscal Year: 2013
    ..at the molecular level, and acetaldehyde accumulation causes facial flushing, tachycardia, headache and nausea, and alcohol avoidance at the physiological level...
  47. Oncologist-Assisted Home Exercise Program for Advanced Colon Cancer Patients
    Karen M Basen Engquist; Fiscal Year: 2010
    ..functioning (self-reported and performance tests) and the secondary outcomes of symptoms (fatigue, sleep, pain, nausea, psychological distress) of patients with advanced colon cancer, compared to an attention control intervention (..
  48. Phosphodiesterease-4 (PDE4) as a Novel Target to Reduce Ethanol Consumption
    Han Ting Zhang; Fiscal Year: 2012
    ..The latter is particularly important given that PDE4B is not involved in nausea and emesis, the primary side effects of PDE4 inhibitors...
  49. THC impairment of CD4/CD8 T cell-mediated host resistance to HIV and influenza
    Norbert E Kaminski; Fiscal Year: 2013
    ..stimulating appetite to alleviate the wasting syndrome that accompanies AIDS and as an antiemetic to relieve the nausea produced by cancer chemotherapy...
  50. Development of NMUR2 Antagonists as Novel Analgesics
    NEIL CUTSHALL; Fiscal Year: 2013
    ..However, these drugs produce severe and unwanted side effects, such as respiratory depression, nausea, constipation and tolerance development (Berde et al, 2008);in addition, they are highly addictive (Koob et al, ..
  51. Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)
    STEPHEN JOHN CUTLER; Fiscal Year: 2013
    ..in the etiology of weight control, the control of the immune system, treatment of cancer, control of nausea and vomiting in patients receiving anti-neoplastic treatment, glaucoma, and the development of sigma receptor ..
  52. Adherence to Swallowing Rehabilitation Exercises in Head and Neck Cancer
    Eileen H Shinn; Fiscal Year: 2013
    ..of Self-Regulation delivering objective and motivational coping strategies for mucositis, xerostomia, fatigue, nausea and dysphagia...
  53. Device for Delivery of Rolipram to Liver for Treatment of Alcoholic Liver Disease
    Leila Gobejishvili; Fiscal Year: 2012
    ..effective PDE4 inhibitor to treat ALD, but in humans systemic administration of the inhibitor induces severe nausea when the drug crosses the blood-brain-barrier...
  54. A Neural Systems Approach to Monitoring and Drug-Delivery for General Anesthesia
    PATRICK PURDON; Fiscal Year: 2009
    ..Other frequent side effects of general anesthesia include cardiovascular and respiratory depression, nausea, and vomiting...
  55. Redesigning General Anesthesia
    Matthew A Wilson; Fiscal Year: 2013
    ..their effects most likely explains a significant component of anesthesia-related morbidity;drug side effects (nausea, hypotension, respiratory depression, hypothermia) are due to actions at sites other than their intended targets ..
  56. INTERSPECIFIC COMPETITION BETWEEN RICKETTSIAE IN TICKS
    Abdu F Azad; Fiscal Year: 2013
    ..RMSF is characterized by headache, fever, myalgia, nausea and vomiting early in the illness and if untreated it could progress to multi-organ failure and death...
  57. CXCR4-Vagal Tone and Gastric motility
    Richard C Rogers; Fiscal Year: 2013
    ..The literature suggests that profound anorexia, gastric stasis, nausea and emesis are frequent complications of CNS pathology in which SDF1 release is prominent...
  58. MULTI-ANALYTE IMMUNOCHROMATOGRAPHIC TEST STRIP FOR BACTERIAL TOXIN DETECTION
    THOMAS W OWEN; Fiscal Year: 2011
    ..The microbes or toxins enter the body through the gastrointestinal tract, and often cause the first symptoms. Nausea, vomiting, abdominal cramps and diarrhea are common symptoms in many foodborne diseases...
  59. Brain Mechanisms for Autonomic Outflow and Nausea in Cyclic Vomiting Syndrome
    Vitaly Napadow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): While the sensation of nausea is universal in the human experience, the brain activity underlying this perceptual state is not well understood...
  60. Functional Networks in Migraine
    Todd Schwedt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Migraine attacks are characterized by moderate to severe ain, nausea, vomiting, increased sensitivity to lights, sounds and odors, and cutaneous allodynia...
  61. Actuated Fine-Gauge Spinal Needle Insertion to Reduce Dura Damage and PDPH Risk
    MAUREEN L MULVIHILL; Fiscal Year: 2012
    ..provides many benefits over general anesthesia including decreased blood loss, decreased post-anesthesia nausea and vomiting, and better post-op pain control...
  62. A Presurgery Hypnosis Training Program for Nurse Anesthetists
    Guy H Montgomery; Fiscal Year: 2011
    ..of women will experience highly aversive side effects following breast conserving surgery, including pain, nausea, and fatigue...
  63. Novel Rinse to Treat Oral Candidiasis in Cancer Patients
    Bakul Bhatt; Fiscal Year: 2007
    ..Furthermore, side effects of Fluconazole include nausea, vomiting, abdominal pain, headaches, dizziness, drowsiness, fever, diarrhea, rash and changes in the sense of ..
  64. Determining Therapeutic Efficacy of AGE in AD
    Neelima Chauhan; Fiscal Year: 2005
    ..These drugs exert serious side effects including gastrointestinal bleeding, liver and renal toxicity, nausea, and are not effective with patients carrying ApoE gene 1...
  65. A MULTI-CHANNEL GASTRIC PACER FOR TREATING GASTROPARESIS
    Robert Ross; Fiscal Year: 2004
    ..In gastroparesis, impaired gastric emptying can lead to nausea, vomiting, premature satiety, abdominal pain, abdominal bloating, weight loss, bacterial overgrowth, and ..
  66. GENETICS OF ALCOHOLISM IN AMERICAN INDIANS
    Richard Deitrich; Fiscal Year: 1993
    ..Orientals with this gene develop a syndrome following alcohol ingestion with facial flushing, tachycardia and some nausea. While the mutation is common in Oriental populations (approx. 45%) it is seen in a very low proportion (approx...
  67. SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEM
    KATHY LEPARD; Fiscal Year: 2001
    ..Diabetic patients often experience a wide range of GI discomforts including heartburn, nausea, vomiting, diarrhea, constipation, fecal incontinence and abdominal pain...
  68. The Treatment of Methotrexate Resistant Rheumatoid Arthritis With Aminopterin
    Stuart Kahn; Fiscal Year: 2009
    ..Especially troubling are gastrointestinal and central nervous system side effects that include nausea, stomatitis, liver irritation, headache, fatigue, disorientation and poor memory...
  69. Transcutaneous electroacupuncture for gastroparesis
    Jiande Chen; Fiscal Year: 2010
    ..Common symptoms of gastroparesis include nausea, vomiting, early satiety and abdominal bloating...
  70. Acupuncture to Prevent Postoperative Paralytic lleus
    JOSEPH CHIANG; Fiscal Year: 2004
    ..quality of life status between treatment and control groups in terms of pain, use of opioid analgesics, nausea, vomiting, insomnia, abdominal distention/fullness, activity, and sense of well-being; and 2) compare costs due to ..
  71. Novel non-invasive treatment for hypotension during hemodialysis
    Anja Metzger; Fiscal Year: 2007
    ..IDH often causes abdominal pain, nausea, vomiting, muscle cramps, dizziness and fainting, slows or terminates the dialysis run, reduces the quality of ..
  72. Dual-pulse electrical stimulation for gastroparesis
    Jiande Chen; Fiscal Year: 2004
    ..indicated that gastric electrical stimulation (GES) with short pulses (in the order of mu s) improves symptoms of nausea and vomiting, whereas gastric electrical stimulation with long pulses (in the order of ms) improves gastric ..
  73. EFFECT OF GINSENG ON CISPLATIN-INDUCED EMESIS
    Chun Su Yuan; Fiscal Year: 2006
    ..b>Nausea/vomiting, a significant adverse effect of chemotherapeutic drugs, should be adequately controlled to reduce ..
  74. Slowing of Transit - The Third Enteric Function of 5-HT
    Henry Lin; Fiscal Year: 2005
    ..Abdominal pain, nausea, bloating, diarrhea and malnutrition are the consequences of impaired control of intestinal transit...