hyperphagia

Summary

Summary: Ingestion of a greater than optimal quantity of food.

Top Publications

  1. ncbi Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice
    Karin Weide
    Max Planck Institut fuer physiologische und klinische Forschung, W G Kerckhoff Institut, D 61231 Bad Nauheim, Germany
    Physiol Genomics 13:47-56. 2003
  2. ncbi Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat
    Takeshi K Watanabe
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Clin Exp Pharmacol Physiol 32:355-66. 2005
  3. ncbi Established diet-induced obesity in female rats leads to offspring hyperphagia, adiposity and insulin resistance
    P Nivoit
    Department of Developmental Biology, Katholieke Universiteit Leuven, Faculty of Medicine, Leuven, Belgium
    Diabetologia 52:1133-42. 2009
  4. ncbi Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
  5. pmc Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene
    Juliette Gray
    University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, CB2 2XY, U K
    Diabetes 55:3366-71. 2006
  6. ncbi Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    I Sadaf Farooqi
    University Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 348:1085-95. 2003
  7. ncbi Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    Heike Munzberg
    Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 145:4880-9. 2004
  8. pmc Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity
    Jacob C Garza
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    J Endocrinol 197:471-82. 2008
  9. ncbi Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
  10. pmc Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
    W E Lyons
    Neural Development Group, Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 96:15239-44. 1999

Detail Information

Publications259 found, 100 shown here

  1. ncbi Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice
    Karin Weide
    Max Planck Institut fuer physiologische und klinische Forschung, W G Kerckhoff Institut, D 61231 Bad Nauheim, Germany
    Physiol Genomics 13:47-56. 2003
    ..energy expenditure measurements from day 21 to 35, onset of excessive fat deposition in MC4r-/- is fueled by hyperphagia and counteracted partially by hypermetabolism...
  2. ncbi Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat
    Takeshi K Watanabe
    Otsuka GEN Research Institute, Otsuka Pharmaceutical Co Ltd, Tokushima, Japan
    Clin Exp Pharmacol Physiol 32:355-66. 2005
    1. We have confirmed the Diabetes Mellitus OLETF type I (Dmo1) effect on hyperphagia, dyslipidaemia and obesity in the Otsuka Long-Evans Tokushima Fatty (OLETF) strain...
  3. ncbi Established diet-induced obesity in female rats leads to offspring hyperphagia, adiposity and insulin resistance
    P Nivoit
    Department of Developmental Biology, Katholieke Universiteit Leuven, Faculty of Medicine, Leuven, Belgium
    Diabetologia 52:1133-42. 2009
    ..We investigated the effects of established maternal diet-induced obesity on male and female offspring appetite, glucose homeostasis and body composition in rats...
  4. ncbi Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming
    Anne Maj Samuelsson
    Division of Reproduction and Endocrinology, King s College London, London, UK
    Hypertension 51:383-92. 2008
    ..Developmentally programmed hyperphagia, physical inactivity, and altered adipocyte metabolism may play a mechanistic role.
  5. pmc Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene
    Juliette Gray
    University Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, CB2 2XY, U K
    Diabetes 55:3366-71. 2006
    ..We report an 8-year-old girl with hyperphagia and severe obesity, impaired cognitive function, and hyperactivity who harbored a de novo chromosomal inversion,..
  6. ncbi Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
    I Sadaf Farooqi
    University Department of Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 348:1085-95. 2003
    ..However, the clinical spectrum and mode of inheritance have not been defined, pathophysiological mechanisms leading to obesity are poorly understood, and there is little information regarding genotype-phenotype correlations...
  7. ncbi Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    Heike Munzberg
    Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 145:4880-9. 2004
    ..Defects in leptin action in the ARC may play a role in the pathogenesis of leptin-resistant obesity...
  8. pmc Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity
    Jacob C Garza
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    J Endocrinol 197:471-82. 2008
    ..Our results provide evidence that AAV-mediated silencing of MC4R on PVN neurons promotes hyperphagia and obesity in response to the dietary challenge in the adult animal.
  9. ncbi Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
    Here we report the presence of hyperphagia, obesity and insulin resistance in knockout mice deficient in IL-18 or IL-18 receptor, and in mice transgenic for expression of IL-18 binding protein...
  10. pmc Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
    W E Lyons
    Neural Development Group, Advanced BioScience Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 96:15239-44. 1999
    ..mice that have a normal life span and show that these animals develop enhanced intermale aggressiveness and hyperphagia accompanied by significant weight gain in early adulthood; these behavioral abnormalities are known to ..
  11. ncbi Ghrelin causes hyperphagia and obesity in rats
    A M Wren
    Endocrine Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Diabetes 50:2540-7. 2001
    ..saline 2.2 +/- 3.8 g, P < 0.05) and adiposity. These data provide evidence that ghrelin is important in long-term control of food intake and body weight and that circulating ghrelin at fasting concentrations may stimulate food intake...
  12. ncbi Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
    I Sadaf Farooqi
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge CB2 2XY, United Kingdom
    J Clin Endocrinol Metab 92:3369-73. 2007
    ..To date, only two unrelated subjects with this disorder have been reported...
  13. pmc A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism
    Adam J de Smith
    Section of Genomic Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Hum Mol Genet 18:3257-65. 2009
    ..We report a 19-year-old male with hyperphagia and severe obesity, mild learning difficulties and hypogonadism, in whom diagnostic tests for Prader-Willi ..
  14. pmc SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice
    Feng Ding
    Department of Genetics, Stanford University, Stanford, California, USA
    PLoS ONE 3:e1709. 2008
    ..Around three months of age, they develop hyperphagia, but stay lean on regular and high-fat diet...
  15. pmc Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function
    Jason G Barrera
    Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Neurosci 31:3904-13. 2011
    ..NTS PPG knockdown caused hyperphagia and exacerbated high-fat diet (HFD)-induced fat accumulation and glucose intolerance...
  16. pmc Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy
    Tingqing Guo
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 61:2414-23. 2012
    ..ectopic lipid deposition, peripheral insulin resistance, reduced adipokine levels, and increased food intake (hyperphagia)...
  17. ncbi Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus
    J L Michaud
    Research Center, Hopital Sainte Justine, 3175 Cote Sainte Catherine, Montreal, Quebec, H3T 1C5, Canada
    Hum Mol Genet 10:1465-73. 2001
    ..Severe obesity was described recently in a patient with a balanced translocation disrupting SIM1. Pathways controlling the development of the PVN thus have the potential to cause obesity in both mice and humans...
  18. ncbi The use of dextroamphetamine to treat obesity and hyperphagia in children treated for craniopharyngioma
    Patrick W Mason
    Inova Fairfax Hospital for Children, Fairfax, VA, USA
    Arch Pediatr Adolesc Med 156:887-92. 2002
    ..Obesity and attention difficulties are known complications following surgical treatment for craniopharyngioma. Treatments to date have been largely disappointing...
  19. pmc Induction of hyperphagia and carbohydrate intake by μ-opioid receptor stimulation in circumscribed regions of frontal cortex
    Jesus D Mena
    Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin 53719, USA
    J Neurosci 31:3249-60. 2011
    ..Here we show that hyperphagia can be driven by μ-opioid receptor stimulation in restricted regions of ventral medial prefrontal cortex (..
  20. ncbi Dopamine is required for hyperphagia in Lep(ob/ob) mice
    M S Szczypka
    Howard Hughes Medical Institute and Department of Biochemistry, Box 357370, University of Washington, Seattle, Washington, USA
    Nat Genet 25:102-4. 2000
    ..Leptin-null (Lep(ob/ob)) mice exhibit obesity, decreased energy expenditure and hyperphagia. As the hypothalamic leptin-melanocortin pathway appears to regulate appetite and metabolism, we generated mice ..
  21. pmc Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia
    Catherine S Mitchell
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Clin Invest 120:1345-54. 2010
    ..Raised energy expenditure and hyperphagia are recognized features of hyperthyroidism, but the effects of comparable hyperthyroxinemia in RTH patients are ..
  22. ncbi Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls
    Sara G Vienberg
    Insulin and Incretin Biology, Hagedorn Research Institute, Niels Steensensvej 4, DK 2820 Gentofte, Denmark
    Eur J Endocrinol 167:49-57. 2012
    ..Fibroblast growth factor 21 (FGF21) is a metabolic factor involved in glucose and lipid metabolism. However, little is known about the physiological role of FGF21 during a dietary challenge in humans...
  23. ncbi Insulin resistance of hypothalamic arcuate neurons in neonatally overfed rats
    Helga Davidowa
    Institut fur Neurophysiologie, Charite, Universitatsmedizin Berlin, Germany
    Neuroreport 18:521-4. 2007
    ..This can be regarded as insulin resistance, which is induced during early development and persists in later life...
  24. ncbi Blunted fasting-induced hypothalamic activation and refeeding hyperphagia in late-onset obesity
    Csilla Becskei
    Institute of Veterinary Physiology and Zurich Centre of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Neuroendocrinology 90:371-82. 2009
    ..A similar impact of hyperinsulinemia and hyperleptinemia in LOO mice is also likely although under the current experimental conditions responsiveness to some effects of these hormones appeared to be reduced...
  25. ncbi Low expression of insulin signaling molecules impairs glucose uptake in adipocytes after early overnutrition
    Ananda L Rodrigues
    Department of Pharmacology, Institute of Biology, State University of Rio de Janeiro, Av 28 de setembro 87 fds, Vila Isabel, Rio de Janeiro 20551 030, RJ, Brazil
    J Endocrinol 195:485-94. 2007
    ..Our data demonstrated that early postnatal overfeeding induced a persistent hyperphagia accompanied by a significant increase in body weight until 90 days of age...
  26. pmc Food reward, hyperphagia, and obesity
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1266-77. 2011
    ..by internal state signals, we analyze the potentially circular relationship between palatable food intake, hyperphagia, and obesity...
  27. pmc Olanzapine-induced hyperphagia and weight gain associate with orexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation
    Johan Fernø
    Dr Einar Martens Research Group for Biological Psychiatry, Department of Clinical Medicine, University of Bergen, Bergen, Norway
    PLoS ONE 6:e20571. 2011
    ..drug treatment in patients with schizophrenia is limited by the propensity of these drugs to induce hyperphagia, weight gain and other metabolic disturbances, particularly evident for olanzapine and clozapine...
  28. pmc Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse
    Ilia N Karatsoreos
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    Endocrinology 151:2117-27. 2010
    ..increases in weight gain, increased adiposity, elevated plasma leptin, insulin and triglyceride levels, hyperphagia, and decreased home-cage locomotion...
  29. ncbi Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice
    Shinya Kojima
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Peptides 30:962-6. 2009
    ..to raise hypothalamic leptin levels, rescued the STZ-pretreated mice from early mortality, gradually curbed hyperphagia to normalize intake by week 20, and maintained BW at significantly lower than the control range...
  30. ncbi Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats
    Churl Namkoong
    Asan Institute for Life Sciences, Ulsan University College of Medicine, Poognap dong, Songpa Gu, Seoul 138 736, Korea
    Diabetes 54:63-8. 2005
    ..Compared with control rats, STZ-induced diabetic rats had significant hyperphagia and weight loss...
  31. ncbi The hyperleptinemia and ObRb expression in hyperphagic obese rats
    Ying Han
    Graduate School, Dong A University College of Medicine, Busan, Republic of Korea
    Biochem Biophys Res Commun 394:70-4. 2010
    ..in high-fat-diet-induced obese rats and aged obese rats is well established, but it is not clear whether hyperphagia-induced obese rats also develop leptin resistance...
  32. pmc Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity
    Lisa M Davis
    Department of International Health, Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Neuroendocrinology 89:152-62. 2009
    ....
  33. ncbi Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat
    Michelle J Hansen
    Neuroendocrine Laboratory, Department of Pharmacology, The University of Melbourne, Victoria, Australia
    J Neurochem 88:909-16. 2004
    ..of differing lengths (2-17 weeks) of high-fat diet on hypothalamic NPY peptide content, release and NPY-induced hyperphagia. Male Sprague-Dawley rats (211 +/- 3 g) were fed either a high-fat diet (30% fat) or laboratory chow (5% fat)...
  34. ncbi Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice
    Pieter Jan Verhulst
    Centre for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium
    Gastroenterology 135:1267-76. 2008
    ..Mice with streptozotocin (STZ)-induced diabetes exhibit hyperphagia, altered gastric emptying, and increased plasma ghrelin levels...
  35. pmc Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia
    Manivannan Subramanian
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    Dis Model Mech 6:734-44. 2013
    ..Thus, reduced InsP3R function alters lipid metabolism and causes hyperphagia in adults. Together, the metabolic and behavioral changes lead to obesity...
  36. ncbi Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice
    Pascal Clerc
    Institut National de la Sante et de la Recherche Medicale Unit 531, Institut Fédératif de Recherche 31, Université de Toulouse 3, 31432 Toulouse Cedex 4, France
    Endocrinology 148:1039-49. 2007
    ..CCK2R(-/-) mice developed obesity that was associated with hyperphagia. Obesity was related with increased fat deposition resulting from adipocyte hypertrophy...
  37. ncbi Circadian feeding drive of metabolic activity in adipose tissue and not hyperphagia triggers overweight in mice: is there a role of the pentose-phosphate pathway?
    Paula Stucchi
    Instituto Pluridisciplinar and Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Endocrinology 153:690-9. 2012
    ..Because PPP is the main source of reduced nicotinamide adenine dinucleotide phosphate, we suggest that PPP inhibition might be an early marker of adipose dysfunction in diet-induced obesity...
  38. ncbi Changes in macronutrient balance during over- and underfeeding assessed by 12-d continuous whole-body calorimetry
    S A Jebb
    MRC Dunn Clinical Nutrition Centre, Cambridge, United Kingdom
    Am J Clin Nutr 64:259-66. 1996
    ..Metabolic fuel selection is dominated by the need to maintain carbohydrate balance. This induces inappropriate counterregulatory alterations in fat oxidation during energy surplus...
  39. pmc Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice
    E A Fox
    Behavioral Neurogenetics Laboratory, Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Neuroscience 229:176-99. 2013
    ..of brain-derived neurotrophic factor (BDNF) cause late- and early-onset obesity, respectively, both involving hyperphagia. Little is known about the mechanism underlying this hyperphagia or whether BDNF loss from peripheral tissues ..
  40. ncbi A role for hypothalamic AMP-activated protein kinase in the mediation of hyperphagia and weight gain induced by chronic treatment with olanzapine in female rats
    Ei Sejima
    Department of Pharmaceutical Care and Health Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    Cell Mol Neurobiol 31:985-9. 2011
    ..to ascertain if hypothalamic AMP-activated protein kinase (AMPK) mediates olanzapine-induced weight gain and hyperphagia. Body weight and food intake in each rat were evaluated every day and every two days, respectively...
  41. pmc Obesity-programmed mice are rescued by early genetic intervention
    Viviana F Bumaschny
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    J Clin Invest 122:4203-12. 2012
    ..To challenge this hypothesis, we generated a reversible genetic mouse model of early-onset hyperphagia and severe obesity by selectively blocking the expression of the proopiomelanocortin gene (Pomc) in ..
  42. pmc Gastric expression of plasminogen activator inhibitor (PAI)-1 is associated with hyperphagia and obesity in mice
    Susan Kenny
    Departments of Cell and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Endocrinology 154:718-26. 2013
    ..PAI-1-H/Kβ mice had increased plasma concentrations of PAI-1 and increased body mass, adiposity, and hyperphagia compared with wild-type mice...
  43. pmc Maternal environmental contribution to adult sensitivity and resistance to obesity in Long Evans rats
    Mariana Schroeder
    Psychology Department, Bar Ilan University, Ramat Gan, Israel
    PLoS ONE 5:e13825. 2010
    The OLETF rat is an animal model of early onset hyperphagia induced obesity, presenting multiple pre-obese characteristics during the suckling period...
  44. ncbi Weight gain by hyperalimentation elevates C-reactive protein levels but does not affect circulating levels of adiponectin or resistin in healthy subjects
    Olov Astrand
    Department of Medical and Health Sciences, Faculty of Health Sciences, Linkoping University, SE 58185 Linkoping, Sweden
    Eur J Endocrinol 163:879-85. 2010
    ..Increase of resistin and/or reduction of adiponectin have been implicated in the development of insulin resistance following weight gain. We aimed to study this prospectively in humans...
  45. ncbi Programmed hyperphagia due to reduced anorexigenic mechanisms in intrauterine growth-restricted offspring
    Mina Desai
    Perinatal Research Laboratories, Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Torrance, California 90502, USA
    Reprod Sci 14:329-37. 2007
    ..When nursed by ad libitum-fed controls, IUGR offspring exhibit hyperphagia with adult obesity, marked by increased percentage body fat and plasma leptin, suggesting altered anorexigenic ..
  46. ncbi Hunger does not diminish over time in mice under protracted caloric restriction
    Catherine Hambly
    Aberdeen Centre for Energy Regulation and Obesity ACERO, Rowett Research Institute, Bucksburn, Aberdeen, Scotland, United Kingdom
    Rejuvenation Res 10:533-42. 2007
    ..We used the magnitude of hyperphagia on release from restriction as a bioassay of hunger in restricted mice...
  47. ncbi A role for arcuate cocaine and amphetamine-regulated transcript in hyperphagia, thermogenesis, and cold adaptation
    Wing May Kong
    Department of Metabolic Medicine, Division of Investigative Sciences, Hammersmith Campus, Faculty of Medicine, Imperial College School of Science, Technology and Medicine, London, UK
    FASEB J 17:1688-90. 2003
    ..Together with the orexigenic and thermogenic effects of CART, this finding suggests a role for arcuate nucleus CART in cold adaptation...
  48. ncbi A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats
    S Bi
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Regul Integr Comp Physiol 281:R254-60. 2001
    ..To examine the potential role of hypothalamic pathways in the hyperphagia and obesity of OLETF rats, we compared patterns of hypothalamic neuropeptide Y (NPY), proopiomelanocortin (POMC)..
  49. ncbi Profound obesity secondary to hyperphagia in mice lacking kinase suppressor of ras 2
    Jean Pierre Revelli
    Lexicon Pharmaceuticals, The Woodlands, Texas, USA
    Obesity (Silver Spring) 19:1010-8. 2011
    ..The obesity and T2D of KSR2(-/-) mice resulted from hyperphagia which was unresponsive to leptin and did not originate downstream of MC4R...
  50. ncbi Evidence for serotonergic modulation of progesterone-induced hyperphagia, depression and algesia in female mice
    Gurpreet Kaur
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Brain Res 943:206-15. 2002
    The acute administration of the neurosteroid precursor, progesterone (10 mg/kg, s.c.) produced significant hyperphagia in female mice as observed at 0.5-, 1-, 2- and 3-h time intervals...
  51. ncbi Rai1 haploinsufficiency causes reduced Bdnf expression resulting in hyperphagia, obesity and altered fat distribution in mice and humans with no evidence of metabolic syndrome
    Brooke Burns
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hum Mol Genet 19:4026-42. 2010
    ..Expression analyses revealed that Bdnf (brain-derived neurotrophic factor), a gene previously associated with hyperphagia and obesity, is downregulated in the Rai1(+/-) mouse hypothalamus, and reporter studies show that RAI1 directly ..
  52. ncbi IGF-I treatment reduces hyperphagia, obesity, and hypertension in metabolic disorders induced by fetal programming
    M H Vickers
    Liggins Institute for Medical Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand 92019
    Endocrinology 142:3964-73. 2001
    ..programming, and we have shown that undernutrition of the mother during gestation leads to programming of hyperphagia, obesity, hypertension, hyperinsulinemia, and hyperleptinemia in the offspring...
  53. pmc Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant
    Jonathan Krakoff
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, Phoenix, AZ, USA
    Diabetes 57:3267-72. 2008
    ..Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure...
  54. pmc Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Philos Trans R Soc Lond B Biol Sci 361:1211-8. 2006
    ..contributes to the OLETF's inability to compensate for their meal size control deficit leading to their overall hyperphagia. Access to a running wheel and the resulting exercise normalizes food intake and body weight in OLETF rats...
  55. ncbi Attention-deficit/hyperactivity disorder: associations with overeating and obesity
    Caroline Davis
    York University, Toronto, Ontario, Canada
    Curr Psychiatry Rep 12:389-95. 2010
    ..This view conforms with the well-established evidence that drug use and abuse are substantially higher among those with ADHD than among the general population...
  56. ncbi Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone
    Akira Gomori
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300 2611, Japan
    Am J Physiol Endocrinol Metab 284:E583-8. 2003
    ..In the MHF diet-fed mice, MCH more clearly increased the body weight accompanied by a sustained hyperphagia and significant increase in fat and liver weights...
  57. ncbi Decision-making deficits and overeating: a risk model for obesity
    Caroline Davis
    York University, 343 Bethune College, 4700 Keele Street, Toronto, ON M3J 1P3, Canada
    Obes Res 12:929-35. 2004
    ..That is, they choose immediate rewards in the face of future long-term negative consequences...
  58. ncbi Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation
    Paulo José Forcina Martins
    Dept of Psychobiology, Universidade Federal de Sao Paulo, Brazil
    Am J Physiol Endocrinol Metab 298:E726-34. 2010
    ..However, no study has verified the relationship between neuropeptide Y (NPY) and orexin changes during hyperphagia induced by sleep deprivation...
  59. pmc Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression
    Kristen P Tolson
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:3803-12. 2010
    ....
  60. ncbi Control of hyperphagia prevents obesity in BDNF heterozygous mice
    Vincenzo Coppola
    Neural Development Group, Mouse Cancer Genetics Program, National Cancer Institute, 7th Street, Bldg 560 Rm 32 31D, P O Box B, Frederick, MD 21702, USA
    Neuroreport 15:2665-8. 2004
    ..Thus, hyperphagia appears to be the primary cause of obesity development rather than changes in mechanisms controlling metabolism.
  61. ncbi Hyperphagia and increased meal size are responsible for weight gain in rats treated sub-chronically with olanzapine
    Nima Davoodi
    Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Psychopharmacology (Berl) 203:693-702. 2009
    ..Atypical antipsychotic-induced weight gain is a significant impediment in the treatment of schizophrenia...
  62. ncbi Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    J C Erickson
    Howard Hughes Institute, University of Washington, Seattle, USA
    Nature 381:415-21. 1996
    ..These results indicate that NPY is not essential for certain feeding responses or leptin actions but is an important modulator of excitability in the central nervous system...
  63. ncbi Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice
    Hella S Jürgens
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Physiol Genomics 25:234-41. 2006
    ..V-Lep(ob)/J (ob/ob) strains (11% and 65% fat at 23 wk, respectively). NZO mice exhibited a significant hyperphagia that, when food intake was expressed per metabolic body mass, was less pronounced than that of the ob/ob strain...
  64. pmc Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees
    Fanny Stutzmann
    Centre National de la Recherche Scientifique 8090, Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 57:2511-8. 2008
    ..However, there is uncertainty regarding the degree of penetrance of this condition, and the putative impact of the environment on the development of obesity in MC4R mutation carriers is unknown...
  65. ncbi Extending the phenotype of monosomy 1p36 syndrome and mapping of a critical region for obesity and hyperphagia
    Carla S D'Angelo
    Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of Sao Paulo, Sao Paulo, Brazil
    Am J Med Genet A 152:102-10. 2010
    ..Our work reinforces the association of monosomy 1p36 and obesity and hyperphagia, and further suggests that these features may be associated with non-classical manifestations of this disorder ..
  66. pmc Postnatal early overnutrition changes the leptin signalling pathway in the hypothalamic-pituitary-thyroid axis of young and adult rats
    Ananda Lages Rodrigues
    Departamento de Ciencias Fisiologicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    J Physiol 587:2647-61. 2009
    ..Rats raised in a small litter can develop hyperinsulinaemia, hyperphagia, hyperleptinaemia and hypertension as adults...
  67. ncbi A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior
    Maria Sakkou
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Cell Metab 5:450-63. 2007
    ..We report that the brain-specific homeobox transcription factor Bsx is required for locomotory behavior, hyperphagia, and expression of the hypothalamic neuropeptides Npy and Agrp, which regulate feeding behavior and body weight...
  68. ncbi SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake
    Bassil M Kublaoui
    Department of Pediatrics, and McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, 75390 8591, USA
    Endocrinology 147:4542-9. 2006
    ..The SIM1 transgene also completely rescued the hyperphagia and partially rescued the obesity of agouti yellow mice, in which melanocortin signaling is abrogated...
  69. ncbi Energy density in cafeteria diet induced hyperphagia in the rat
    Amir Shafat
    Department of Biomedical Science, University of Sheffield, Alfred Denny Building, Western Bank, Sheffield S10 2TN, UK
    Appetite 52:34-8. 2009
    ..Presenting a varied and energy-dense diet often leads to hyperphagia and weight gain...
  70. pmc Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure
    Dong Xi
    Division of Endocrinology and Diabetes, Department of Pediatrics, School of Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS ONE 7:e36453. 2012
    ..Previously we showed that Sim1(+/-) mice and conditional postnatal Sim1(-/-) mice exhibit hyperphagia, obesity, increased linear growth and susceptibility to diet-induced obesity, but no decrease in energy ..
  71. ncbi Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism
    Luis Varela
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, Santiago de Compostela A Coruña 15782, Spain
    J Pathol 227:209-22. 2012
    Hyperthyroidism is characterized in rats by increased energy expenditure and marked hyperphagia. Alterations of thermogenesis linked to hyperthyroidism are associated with dysregulation of hypothalamic AMPK and fatty acid metabolism; ..
  72. ncbi Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    Silvana Obici
    Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Neurosci 5:566-72. 2002
    ..This selective decrease in hypothalamic insulin receptor protein was accompanied by rapid onset of hyperphagia and increased fat mass...
  73. ncbi Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding
    R J Seeley
    Department of Psychology, University of Washington, Seattle 98195 1525, USA
    Am J Physiol 271:R819-23. 1996
    ..Furthermore, the hypothalamic NPY response to food restriction is not tied to low food intake per se, but rather to negative energy balance...
  74. ncbi Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2 1 Seiryou machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Endocrinology 147:5893-900. 2006
    ..down-regulates hypothalamic 5-HT2C and 5-HT1B receptor gene expression under restricted feeding conditions, whereas chronic hyperphagia increases the expression of these genes and decreases plasma des-acyl ghrelin levels in Ay mice.
  75. ncbi Distinct forebrain and caudal brainstem contributions to the neuropeptide Y mediation of ghrelin hyperphagia
    Lucy F Faulconbridge
    Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Diabetes 54:1985-93. 2005
    Neuropeptide Y (NPY) has been implicated in the downstream mediation of ghrelin hyperphagia, with the site of action for both peptides considered to be intrinsic to the hypothalamus...
  76. ncbi Adaptation to a high-fat diet leads to hyperphagia and diminished sensitivity to cholecystokinin in rats
    David M Savastano
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, University Park, 16802 6504, USA
    J Nutr 135:1953-9. 2005
    ..These results demonstrate that chronic ingestion of a HF diet leads to short-term overconsumption of a high-energy, high-fat food compared with LF-fed cohorts, which is associated with a decreased sensitivity to CCK...
  77. ncbi Role of ghrelin in streptozotocin-induced diabetic hyperphagia
    Shinya Ishii
    Department of Medicine, Nippon Medical School, Tokyo 113 8603, Japan
    Endocrinology 143:4934-7. 2002
    ..STZ-treated diabetic rats were markedly hyperphagic. This hyperphagia was accompanied by hyperglycemia, hypoinsulinemia, and reduced plasma GH levels...
  78. ncbi Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects
    Timothy H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Psychobiol 48:360-7. 2006
    ..is also evident in preobese, juvenile OLETF rats suggesting a causal role for this overexpression in the hyperphagia and obesity. Running wheel exercise normalizes food intake and body weight in OLETF rats...
  79. pmc Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice
    Tsung Yin J Yeh
    Department of Medicine, Endocrine Division, University of California, San Diego, La Jolla, California, USA
    Diabetes 58:2476-85. 2009
    ..Its chromosomal locus 8p23.1 is linked to monogenic forms of diabetes in certain kindred. We hypothesize that TNKS is involved in energy homeostasis in mammals...
  80. pmc Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
    Bassil M Kublaoui
    Department of Pediatrics, Department of Internal Medicine, McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, Dallas, TX 75390 8591, USA
    Mol Endocrinol 22:1723-34. 2008
    ..Consequently, we hypothesized that altered PVN neuropeptide expression mediates the hyperphagia of Sim1(+/-) mice...
  81. ncbi Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice
    J Lloyd Holder
    Dept of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8591, USA
    Am J Physiol Endocrinol Metab 287:E105-13. 2004
    ..To investigate the relation between Sim1 dosage and hyperphagia, we generated sim1-knockout mice and studied their growth and feeding behavior...
  82. ncbi Involvement of stomach ghrelin and hypothalamic neuropeptides in tumor necrosis factor-alpha-induced hypophagia in mice
    Mizuki Endo
    Department of Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idaigaoka, Yufu Hasama, Oita, 879 5593 Japan
    Regul Pept 140:94-100. 2007
    ..Taken together, these findings suggest that hypothalamic POMC and AGRP and stomach ghrelin may be involved in TNF-alpha-induced hypophagia in mice...
  83. ncbi Hyperphagia as a mediator of renal disease initiation in obese Zucker rats
    F T Stevenson
    Division of Nephrology, Department of Internal Medicine, School of Medicine, University of California Davis, 95616, USA
    Obes Res 9:492-9. 2001
    ..We sought to determine whether prevention of overeating would block the very earliest manifestations of renal injury in young obese Zucker rats (OZRs)...
  84. ncbi Increased production of active ghrelin is relevant to hyperphagia in nonobese spontaneously diabetic Torii rats
    Hiroharu Mifune
    Institute of Animal Experimentation, Kurume University School of Medicine, Kurume 830 0011, Japan
    Metabolism 61:491-5. 2012
    ..The SDT rats with uncontrolled hyperglycemia show hyperphagia with a concomitant increase of plasma active ghrelin concentration...
  85. ncbi Improvement of hyperphagia by activation of cerebral I(1)-imidazoline receptors in streptozotocin-induced diabetic mice
    H H Chung
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
    Horm Metab Res 44:645-9. 2012
    ..In the present study, we used the agonist of I1R to investigate the effect on hyperphagia in streptozotocin (STZ)-induced diabetic mice...
  86. pmc Cannabinoid-induced hyperphagia: correlation with inhibition of proopiomelanocortin neurons?
    Jennie Ho
    Department of Basic Medical Sciences, Western University of Health Sciences, Pomona, CA 91766, United States
    Physiol Behav 92:507-19. 2007
    ..These data demonstrate that cannabinoids regulate appetite in the guinea pig in part through both presynaptic and postsynaptic actions on anorexigenic POMC neurons...
  87. ncbi Ziprasidone and aripiprazole attenuate olanzapine-induced hyperphagia in rats
    S Snigdha
    Bradford School of Pharmacy, University of Bradford, West Yorkshire BD7 1DP, UK
    J Psychopharmacol 22:567-71. 2008
    ..001), neither of which affected food intake alone. The lack of hyperphagia induced by aripiprazole and ziprasidone may reflect an inherent pharmacological mechanism preventing weight gain...
  88. ncbi Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity
    Yanyun Chen
    Division of Endocrinology, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Endocrinology 143:2469-77. 2002
    ..Our data firmly establish MCHR1 as a mediator of MCH effects on energy homeostasis and suggest that inactivation of MCHR1 alone is capable to counterbalance obesity induced by a high-fat diet...
  89. ncbi Hyperphagia and obesity in Na,K-ATPase alpha2 subunit-defective mice
    Kiyoshi Kawakami
    Division of Biology, Center for Molecular Medicine, Jichi Medical School, Yakushiji, Minamikawachi, Kawachi, Tochigi 329 0498 Japan
    Obes Res 13:1661-71. 2005
    ..The aim of this study was to examine whether Atp1a2-defective heterozygous mice show obesity and reveal the mechanisms underlying the obesity...
  90. ncbi Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism
    P D Raposinho
    Department of Pediatrics, Division of Pediatric Endocrinology and Diabetology, University of Geneva School of Medicine, 1211 Geneva 14, Switzerland
    Mol Cell Endocrinol 185:195-204. 2001
    ..chronic infusion of NPY into the lateral ventricle of normal rats produced an obesity syndrome characterized by hyperphagia, hyperinsulinism and collapse of reproductive function...
  91. ncbi Role of endogenous ghrelin in the hyperphagia of mice with streptozotocin-induced diabetes
    J Dong
    Center for Gastroenterological Research, Catholitic University of Leuven, 3000 Leuven, Belgium
    Endocrinology 147:2634-42. 2006
    ..To investigate the role of ghrelin in the hyperphagia associated with uncontrolled streptozotocin-induced diabetes, food intake was followed in diabetic ghrelin ..
  92. ncbi Alpha1 receptor antagonist in the median raphe nucleus evoked hyperphagia in free-feeding rats
    Samira Schultz Mansur
    Department of Physiological Sciences, Centre of Biological Sciences CCB, Federal University of Santa Catarina UFSC, 88040 970, Florianopolis, SC, Brazil
    Appetite 57:498-503. 2011
    ..PRA in the MnR followed by PHE did not change the feeding behavior, PRA injection alone into the MnR caused hyperphagia accompanied by a reduction in the latency to start eating, an increase in feeding frequency and an increase in ..
  93. ncbi Hyperphagia by self- and xeno-cannibalism: cell death by indigestion?: a reminiscence of the Phedrus Fabula "Rana Rupta et Bos"?
    Antonella Tinari
    Istituto Superiore di Sanita, Rome, Italy
    Autophagy 4:128-30. 2008
    ..Under this point of view, over-feeding cells are reminiscent of the frog in the Phedrus Fabula "Rana Rupta et Bos"...
  94. ncbi Implicit wanting and explicit liking are markers for trait binge eating. A susceptible phenotype for overeating
    Graham Finlayson
    BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Appetite 57:722-8. 2011
    ..Trait binge eating is functional at low levels and implicit wanting measured simultaneously with explicit liking may be useful markers for reward-driven overconsumption in this susceptible phenotype...
  95. ncbi Ecological momentary assessment of obesogenic eating behavior: combining person-specific and environmental predictors
    J Graham Thomas
    Department of Psychology, Drexel University, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1574-9. 2011
    ..Individuals practicing weight control may benefit from limiting their exposure to good tasting high-calorie food in their immediate environment...
  96. pmc Attenuation of obesity by early-life food restriction in genetically hyperphagic male OLETF rats: peripheral mechanisms
    Mariana Schroeder
    Life Sciences Faculty, Bar Ilan University, Ramat Gan 52900, Israel
    Horm Behav 57:455-62. 2010
    ..In the present study, we used the OLETF rat model of early-onset hyperphagia induced obesity, which become obese as a result of the absence of CCK(1) receptors, to examine the influence of ..
  97. ncbi Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
    K Nonogaki
    Department of Psychiatry and Center for Neurobiology and Psychiatry, University of California at San Francisco, 94143 0984, USA
    Nat Med 4:1152-6. 1998
    ..Chronic hyperphagia leads to a 'middle-aged'-onset obesity associated with a partial leptin resistance of late onset...
  98. ncbi Amphetamine-sensitized rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia
    Nicole M Avena
    Department of Psychology, Green Hall, Princeton University, Princeton, NJ 08544, USA
    Pharmacol Biochem Behav 74:635-9. 2003
    ....
  99. ncbi Hyperphagia contributes to the normal body composition and protein-energy balance in HIV-infected asymptomatic men
    Pascal Crenn
    Department of Medicine, Infectious Diseases and Clinical Nutrition, Raymond Poincaré Hospital AP HP, Garches, Versailles Saint Quentin en Yvelines University, Paris, France
    J Nutr 134:2301-6. 2004
    ..Moderate hyperphagia, which occurred despite increased levels of cytokines, in conjunction with increased protein synthesis ..
  100. ncbi Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression
    Ruojing Yang
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:23418-25. 2003
    ..Finally, the hyperphagia induced by STZ injection was completely reversed by GMDeltaC expression in liver...
  101. pmc Hypothalamic neuropeptide Y (NPY) and the attenuation of hyperphagia in streptozotocin diabetic rats treated with dopamine D1/D2 agonists
    Dong Yih Kuo
    Department of Physiology, Chung Shan Medical University, Taichung City, Taiwan 40201, ROC
    Br J Pharmacol 148:640-7. 2006
    ..6. It is demonstrated that the response of D1/D2 agonist-induced appetite suppression is attenuated in diabetic rats compared to normal rats and that elevated hypothalamic NPY content may contribute to this alteration...

Research Grants67

  1. Iron, Metabolic Regulation and Type 2 Diabetes Risk
    Donald A McClain; Fiscal Year: 2013
    ..signaling in macrophages and adipocytes, will be examined in mouse models with normal glucose tolerance, hyperphagia, diabetes, and with genetic inactivation of the hepcidin gene. 3...
  2. Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats
    Haifei Shi; Fiscal Year: 2010
    ..the BDNF gene or reducing expression of its specific receptor tropomyosin- related kinase B (TrkB) leads to hyperphagia and obesity, with females having more potent phenotypes and developing more severe obesity than males, ..
  3. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..Such low-grade inflammation in TLR5KO mice resulted in hyperglycemia, hyperlipidemia, hyperphagia, insulin resistance, obesity, hepatic steatosis and hypertension, collectively referred to as metabolic ..
  4. Mechanisms of Diabetic Hyperphagia and Insulin Resistance
    Michael W Schwartz; Fiscal Year: 2012
    ..of responses implicated in the pronounced increase of food intake characteristic of uDM (termed "diabetic hyperphagia")...
  5. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
    ..In both NEXLPL-/- and NEXLPL a period of hyperphagia precedes obesity followed by marked reductions in metabolic rate ensue...
  6. Maternal Hyperinsulinemia and Fetal Programming
    Mulchand S Patel; Fiscal Year: 2011
    ..environment, achieved by dietary or pharmacological interventions imposed on 1-HC female rats to reduce hyperphagia and body weight gain, will reverse the transgenerational effect for 2-HC offspring...
  7. Interaction of Estrogen and AMPK in the Hypothalamus
    Jessica Healy; Fiscal Year: 2012
    ..In women, decreases in estradiol occur during menopause and may lead to hyperphagia and obesity. Estradiol is anorexigenic in rodents and humans...
  8. Neurochemistry/physiology of proopiomelanocortin neurons
    MALCOLM JAMES LOW; Fiscal Year: 2013
    ..of POMC function from the brain results in profound obesity and a metabolic syndrome characterized by extreme hyperphagia and reduced basal metabolic rate...
  9. BRAIN GLUCOSENSING NEURONS IN HEALTH AND DIABETES
    Barry E Levin; Fiscal Year: 2013
    ..have an inborn elevation of ARC GK in association with altered numbers of glucose and FA sensing VMN neurons, hyperphagia when exposed to HE diet and a blunted CRR to IIH as compared to selectively bred diet-resistant (DR) rats...
  10. Mechanisms of Programmed Gestational Hyperphagia
    MICHAEL GLENN ROSS; Fiscal Year: 2012
    ..cellular responsiveness), and 2) leptin administration to IUGR newborns will prevent programmed offspring hyperphagia. The proposed studies will determine mechanisms of impaired satiety-induced hyperphagia, focusing on the leptin ..
  11. INTERACTIONS OF LEPTIN AND CENTRAL SEROTONIN SYSTEMS
    Joel K Elmquist; Fiscal Year: 2013
    ..mouse model, and we found that re-expression of 5-HT2CR only in pro-opiomelanocortin (POMC) neurons rescues hyperphagia, obesity and insulin resistance caused by global deletion of 5-HT2CR...
  12. Cellular Mechanisms of Hypothalamic Inflammation in High Fat Diet-Induced Obesity
    Joshua P Thaler; Fiscal Year: 2013
    ..At the onset of high-fat feeding, there is a period of early hyperphagia and a concomitant inflammatory response specifically in the hypothalamus...
  13. BMP7 and the regulation of central and peripheral energy balance
    Kristy Townsend; Fiscal Year: 2012
    ..that mice with POMC-neuron (ie: in hypothalamus and NTS/brainstem) deletion of BMPR1a (a BMP7 receptor) exhibit hyperphagia as well as increased energy expenditure and BAT thermogenesis...
  14. Cholecystokinin - Role in postprandial gastric motility
    Helen E Raybould; Fiscal Year: 2013
    ..lipid is attenuated by long term ingestion of a high fat diet, leading to a reduction in short term satiety, hyperphagia and altered body weight regulation...
  15. Therapeutic Opportunities of Targeting Tissue Factor Signaling in Obesity
    Fahumiya Samad; Fiscal Year: 2013
    ..fat diet (HFD) fed C57BL/6J mouse model of obesity simulates the human condition, including feeding behavior (hyperphagia), weight gain/energy metabolism, and the development of the metabolic syndrome characterized by insulin ..
  16. NEURAL HIERARCHY IN THE MODULATION OF INGESTIVE BEHAVIOR
    Harvey J Grill; Fiscal Year: 2013
    ..reduction in endogenous mNTS leptin receptor (LepRb) signaling (RNA interference [RNA-i]-mediated) triggers hyperphagia and weight gain, in part, via reduction in the food intake suppressive effect of GI satiation signals...
  17. The role of vagal afferent neurons in regulating feeding behavior
    GUILLAUME FH DE LARTIGUE; Fiscal Year: 2013
    ..with specific focus on understanding how dysregulation of vagal afferent signaling leads to the development of hyperphagia and weight gain in diet induced obesity...
  18. Patterns of Infusion of Anorexigenic Substances that Reduce Obesity
    ROGER REIDELBERGER; Fiscal Year: 2012
    ..a caloric restriction-induced weight loss of 10% in diet-induced obese (DIO) rats, attenuates post-restriction hyperphagia and weight regain...
  19. PERINATAL METABOLIC AND HORMONAL EFFECTS
    Sherin U Devaskar; Fiscal Year: 2010
    ..provoke a cascade of hypothalamic adaptive events, which lend towards a permanency by culminating in hyperphagia/inactivity, visceral adiposity, insulin and leptin resistance...
  20. Regulation of Hypothalamic POMC by Leptin
    Christian Bjorbaek; Fiscal Year: 2010
    ..or leptin receptors, or have mutations in the POMC or the melanocortin receptor genes, suffer from severe hyperphagia, obesity, and insulin resistance...
  21. RNA editing-mediated modulation of serotonin 2C receptor protein expression
    RANDI JO ULBRICHT; Fiscal Year: 2011
    ..by an initial failure to thrive, cognitive deficits, decreased somatic growth, neonatal muscular hypotonia, and hyperphagia associated with morbid obesity...
  22. Cilial dysfunction and pathogenesis of obesity
    Bradley K Yoder; Fiscal Year: 2010
    ..of cilia in the adult mouse and more specifically in the hypothalamus results in rapid onset obesity due to hyperphagia. The phenotype is additionally associated with the development of hyperleptinemia and hyperinsulinemia...
  23. Oxytocin and Oxytocin Neurons in the Hypothalamic Regulation of Feeding
    Bassil M Kublaoui; Fiscal Year: 2012
    ..When treated with Oxt by central administration, their hyperphagia was rescued at doses that did not affect wild-type mice...
  24. Role of Sim1 in Hyperphagic Obesity
    Bassil M Kublaoui; Fiscal Year: 2010
    ..mice have the phenotypic constellation suggested to be a hallmark of defective melanocortin signaling, namely hyperphagia, obesity, increased length, and a sensitivity to high fat...
  25. Sim1 Function in Feeding Regulation
    Andrew R Zinn; Fiscal Year: 2013
    ..how Sim1 haploinsufficiency results in defective Mc4r signaling and how these changes relate to the associated hyperphagia and obesity...
  26. High Fat Feeding Promotes Malfunction of the Nodose Ganglia
    Chung Owyang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Prolonged ingestion of a high fat diet (HFD) is associated with hyperphagia and obesity...
  27. Correction of obesity by optogenetic manipulation of striatal neurons
    ELIZABETH KATHERINE SCHWARTZ; Fiscal Year: 2013
    ..expressing NAc medium spiny neurons will increase feeding behavior and feeding-induced reward, and will lead to hyperphagia and weight gain...
  28. Hepatic Mitochondria and Insulin Resistance in Fatty Liver and Type 2 Diabetes
    RANDY SCOTT RECTOR; Fiscal Year: 2013
    ..will conduct studies in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a well characterized rodent model of hyperphagia-induced obesity, NAFLD, and type 2 diabetes to examine the following specific aims...
  29. Synphilin-1 and obesity
    Wanli W Smith; Fiscal Year: 2013
    ..synphilin-1 modulates hypothalamic feeding related gene expression and AMPK signaling cascades resulting in hyperphagia and obesity...
  30. The TSC-mTOR pathway in cellular and organismal energy metabolism
    Kun Liang Guan; Fiscal Year: 2013
    ..To elucidate the mechanism of mTOR activation in inducing leptin resistance and hyperphagia Aim 4...
  31. The role of caveolae &insulin signaling in CNS insulin transport
    GREGORY KEE PUM HONG; Fiscal Year: 2013
    ..Defects in CNS insulin action result in hyperphagia, weight gain, and dysregulated hepatic glucose production (42)...
  32. Central Regulation of Hepatic Energy Stores
    Allison W Xu; Fiscal Year: 2013
    ..PI3K signaling pathway leads to decreased hepatic sympathetic tone and increased triglyceride levels without hyperphagia and weight gain...
  33. Role of Oxytocin Signaling in the Pathogenesis of Diet-Induced Obesity
    JAMES ERNEST BLEVINS; Fiscal Year: 2013
    ..downstream signaling to brain circuits that regulate food intake and energy expenditure, thereby promoting hyperphagia and obesity...
  34. BDNF and TrkB-containing neuronal circuits mediating energy balance
    Maribel Rios; Fiscal Year: 2013
    ..evidence includes the robust effects of energy status on expression of BDNF and TrkB in the VMH and the hyperphagia and obesity elicited by selectively deleting BDNF in the VMH of adult mice...
  35. GENETIC COMPLEMENTATION OF A MOUSE MODEL FOR PWS
    James L Resnick; Fiscal Year: 2010
    ..infantile hypotonia, short stature, and neonatal failure to thrive followed by obsessive-compulsive behavior, hyperphagia, and obesity...
  36. Interactions between neuronal networks that regulate food intake and body weight
    Lori M Zeltser; Fiscal Year: 2013
    ..LeprHYP mice exhibit early-onset hyperphagia and obesity;however, they maintain stable levels of adiposity from 8 weeks of age...
  37. Neural regulation of protein ingestion
    Christopher D Morrison; Fiscal Year: 2013
    ..the hypothesis that reduced amino acid signaling within specific areas of the hypothalamus contributes to the hyperphagia induced by negative protein balance, and 2) Test the hypothesis that mTOR signaling, AMPK signaling, and/or ..
  38. HPA axis dysregulation and phenomenology of depression
    Erik Nelson; Fiscal Year: 2009
    ..associated with hyperarousal and anorexia in melancholia, whereas low HPA activity is linked with fatigue and hyperphagia in atypical depression...
  39. Opioid modulation of neural encoding of motivation and reward
    Sharif A Taha; Fiscal Year: 2013
    ..However, the mechanisms through which sNAcc MOR stimulation causes hyperphagia, and how diet-induced changes in this circuit contribute to binge eating behavior, remain poorly understood...
  40. Predicting Phenotypic Trajectories in Prader-Willi Syndrome
    ELISABETH MAY DYKENS; Fiscal Year: 2013
    ..characterized by intellectual disabilities;compulsivity;tantrums;irritability;growth hormone dysfunction;hyperphagia;and increased risks of morbid obesity, psychosis, and autism spectrum disorders (ASD)...
  41. Sustaining factors for stress-induced emotional feeding in females
    Mark E Wilson; Fiscal Year: 2013
    ..case, as subordinate females consume significantly more calories when given a high caloric diet (HCD) and this hyperphagia persists when a healthier diet is exclusively available...
  42. Myostatin Family Signaling in Burn-Injury Related Muscle Wasting
    Teresa A Zimmers; Fiscal Year: 2013
    ..We developed a mouse model of burn injury that causes long- term hyperinflammation and catabolism despite hyperphagia. Myostatin family signaling was increased in skeletal muscle after burn...
  43. Developmentally Programmed Hyperphagia and Obesity via BPA enhanced Neurogenesis
    MICHAEL GLENN ROSS; Fiscal Year: 2013
    ..Using both NPC neurosphere culture and in vivo/ex vivo rodent studies, this proposal provides a unique opportunity to determine mechanisms of programmed hyperphagia in BPA-exposed offspring which contribute to offspring obesity.
  44. Sensory Controls of Hyperphagia in Obesity
    Gary Schwartz; Fiscal Year: 2009
    ..Obesity represents an important dysfunctional state of energy balance, and is frequently accompanied by hyperphagia that is manifested by increased meal size...
  45. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
    ..The proposed investigations examine the influence of the duration of diabetes, the effects of hyperphagia and caloric malnutrition, and the influence of glycemic control with insulin on gastric emptying...
  46. A Genetic-Neuroanatomic Dissection of MC4R function
    Bradford B Lowell; Fiscal Year: 2013
    ..Indeed, absence of MC4Rs causes marked hyperphagia and massive obesity...
  47. Neural-Specific Regulation of POMC Gene Expression
    Malcolm Low; Fiscal Year: 2005
    ..Null mutations of the POMC gene have rarely been associated with early onset morbid obesity and hyperphagia in children...
  48. Molecular mechanisms underlying parallel Agouti adaptation in Peromyscus
    CATHERINE LINNEN; Fiscal Year: 2009
    ..Agouti protein and are associated with severe pleiotropic effects that include embryonic lethality, diabetes, hyperphagia, tumor susceptibility, and obesity in laboratory mice...
  49. BRAIN MONOAMINES AND LUTEINIZING HORMONE SECRETION
    William Crowley; Fiscal Year: 2003
    ..Because lactation is also characterized by a marked physiological hyperphagia, and because NPY is the most powerful central stimulant of feeding behavior, one set of proposed experiments ..
  50. Characterizing the function of Syndecan during CNS development
    Karl Johnson; Fiscal Year: 2009
    ..In addition, because mutations in Sdc cause hyperphagia in mouse model systems, and are correlated with obesity in human populations, elucidating the mechanisms of Sdc ..
  51. REGULATION OF RNA EDITING IN THE CNS
    Ronald B Emeson; Fiscal Year: 2010
    ..1) Mutant mice misexpressing an ADAR2 transgene demonstrate a hyperphagia-mediated, maturity-onset obesity accompanied by hyperglycemia and hypercortisolism...
  52. Clonidine Treatment for Neonatal Abstinence Syndrome
    Estelle Gauda; Fiscal Year: 2006
    ..poor feeding, tachycardia, hypertension, diaphoresis, restlessness, insomnia, irritability, tremors, clonus, hyperphagia with poor growth and acidosis, reversible neurologic abnormalities, and even seizures...
  53. LEPTIN ACTION ON HYPOTHALAMIC PEPTIDES GOVERNING FEEDING
    Abhiram Sahu; Fiscal Year: 2001
    ..the NPY and NT systems and in leptin receptor function that may be anticipated to occur in association with the hyperphagia and subsequent return to the control condition that follows withdrawl from chronic leptin infusion...
  54. Neurochemistry of Stress-Induced Binge Eating
    MARY BOGGIANO; Fiscal Year: 2006
    ..from foot shock alone, does not alter food intake, but in rats with a history of cFR, stress produces powerful hyperphagia that is characteristic of binge-eating...
  55. Skeletal Muscle Microcirculation in Obese Zucker Rats
    Jefferson Frisbee; Fiscal Year: 2009
    ..excellent model for examining the impact of Syndrome X on the peripheral microcirculation, as owing to chronic hyperphagia, OZR sequentially develop type II DM, hypertriglyceridemia, and moderate hypertension...
  56. HYPOTHALAMIC DYSFUNCTION
    Patrick Tso; Fiscal Year: 1999
    ..The phenotype shows several behavioral, metabolic and endocrine abnormalities such as hyperactivity, hyperphagia, hyperlipidemia, hyperinsulinemia, increased fat deposition and fatty liver...
  57. ADRENAL-PANCREAS INTERACTIONS: INTAKE & WEIGHT CONTROL
    THOMAS CASTONGUAY; Fiscal Year: 1993
    ..The prominent disturbances seen in most species with elevated corticoid levels are hyperphagia, obesity, hyperinsulinemia, abnormal glucoregulation and glucose intolerance...
  58. Role of hypothalamic PPAR-gamma in the control of food intake and body weight
    DAVID ALEXANDER SARRUF; Fiscal Year: 2010
    ..activation to promote adipocyte differentiation and lipid storage, studies have confirmed that TZDs induce hyperphagia in rodents and that this increase in food consumption largely accounts for weight gain induced by these drugs...
  59. The Agouti Related Protein and its Role in Human Obesity
    George Argyropoulos; Fiscal Year: 2007
    ..by applicant): The Agouti Related Protein (AGRP) is upregulated in obese and diabetic mice and stimulates hyperphagia and the development of obesity when overexpressed in transgenic mice...
  60. NUTRITIONAL & METABOLIC REGULATION OF BODY WEIGHT
    RICHARD GALBRAITH; Fiscal Year: 2003
    ..There is evidence, derived from the observation that inhibitors of nitric oxide synthase oppose the hyperphagia caused by many disparate stimuli, to suggest that the locus of action of nitric oxide may be distal to the ..
  61. Food intake and obesity in cloned mice
    Randall R Sakai; Fiscal Year: 2010
    ..Specific Aims are: 1) To determine whether obesity in cloned mice is the result of hyperphagia or differences in metabolic rate during early postnatal development...
  62. GENETIC AND PHYSIOLOGICAL REGULATION IN BROWN ADIPOCYTES
    Michael Sitrin; Fiscal Year: 2004
    ..Ablation of BAT in transgenic mice causes obesity in the absence of hyperphagia confirming the important role of BAT in energy balance...
  63. ENTEROGLUCAGON AND INTESTINAL ADAPTATION
    Jared Diamond; Fiscal Year: 1992
    ..absorption of all nutrients increases, under many conditions associated with increased energy needs leading to hyperphagia. Second, specific intestinal transporters are up- or down-regulated by changes in dietary levels or body stores ..
  64. ANIMAL MODELS OF EXTREME HYPERPHAGIA AND HIGH METABOLISM
    Jared Diamond; Fiscal Year: 2001
    DESCRIPTION: The long term goal is to develop and exploit a new animal model for studying hyperphagia and high metabolic rate...
  65. Regulation of food intake by melanocortin 4 receptors on neurons of the PVN
    Linh Vong; Fiscal Year: 2009
    ..Targeted deletion of MC4R in rodents resulted in a marked increase in food intake or hyperphagia, reduced energy expenditure, and obesity...
  66. HYPOTHALAMIC PEPTIDES, FOOD INTAKE, AND DIABETES
    Michael Schwartz; Fiscal Year: 2006
    ..Several observations suggest that the effect of uDM to increase food intake, known as diabetic hyperphagia, results at least in part from these ARC neuronal responses...
  67. MECHANISMS OF UCP REGULATION BY LEPTIN
    Thomas Gettys; Fiscal Year: 2001
    ..These mice are characterized by morbid obesity, hyperphagia, low sympathetic output, compromised thermogenic capacity and enhanced energy efficiency...