heartburn

Summary

Summary: Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.

Top Publications

  1. pmc Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease
    E Savarino
    Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Gut 58:1185-91. 2009
  2. ncbi Time trends of gastroesophageal reflux disease: a systematic review
    Hashem B El-Serag
    Gastroenterology and Health Services Research Sections, Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 5:17-26. 2007
  3. ncbi Management of heartburn not responding to proton pump inhibitors
    R Fass
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
    Gut 58:295-309. 2009
  4. ncbi Screening for Barrett's esophagus in colonoscopy patients with and without heartburn
    Douglas K Rex
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Gastroenterology 125:1670-7. 2003
  5. ncbi Response of regurgitation to proton pump inhibitor therapy in clinical trials of gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 106:1419-25; quiz 1426. 2011
  6. ncbi The effect of dexlansoprazole MR on nocturnal heartburn and GERD-related sleep disturbances in patients with symptomatic GERD
    Ronnie Fass
    Southern Arizona VA Health Care System, Section of Gastroenterology 111G 1, Tucson, Arizona 85723, USA
    Am J Gastroenterol 106:421-31. 2011
  7. ncbi Randomised clinical trial: a multicentre, double-blind, placebo-controlled study on the efficacy and safety of rabeprazole 5 mg or 10 mg once daily in patients with non-erosive reflux disease
    Y Kinoshita
    Department of Internal Medicine II, Shimane University, Izumo, Japan
    Aliment Pharmacol Ther 33:213-24. 2011
  8. ncbi Functional esophageal disorders
    Jean Paul Galmiche
    University of Nantes, Nantes, France
    Gastroenterology 130:1459-65. 2006
  9. ncbi Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease
    David A Johnson
    Eastern Virginia Medical School, Division of Gastroenterology, Norfolk, 23505, USA
    Gastroenterology 126:660-4. 2004
  10. ncbi Predictors of heartburn during sleep in a large prospective cohort study
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
    Chest 127:1658-66. 2005

Detail Information

Publications275 found, 100 shown here

  1. pmc Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease
    E Savarino
    Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Gut 58:1185-91. 2009
    ..Still, patients with NERD represent a very heterogeneous group and limited data on dyspeptic symptoms in various subgroups of NERD are available...
  2. ncbi Time trends of gastroesophageal reflux disease: a systematic review
    Hashem B El-Serag
    Gastroenterology and Health Services Research Sections, Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Gastroenterol Hepatol 5:17-26. 2007
    ..First, population-based studies that reported the prevalence of at least weekly heartburn and/or acid regurgitation were subjected to a time-trend analysis with a Poisson regression model...
  3. ncbi Management of heartburn not responding to proton pump inhibitors
    R Fass
    The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
    Gut 58:295-309. 2009
    ..These include weakly acidic reflux, duodenogastro-oesophageal reflux, residual acid reflux and functional heartburn, as well as others...
  4. ncbi Screening for Barrett's esophagus in colonoscopy patients with and without heartburn
    Douglas K Rex
    Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
    Gastroenterology 125:1670-7. 2003
    ..The population prevalence of Barrett's esophagus (BE) is uncertain. Our aim was to describe the prevalence of BE in a volunteer population...
  5. ncbi Response of regurgitation to proton pump inhibitor therapy in clinical trials of gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
    Am J Gastroenterol 106:1419-25; quiz 1426. 2011
    The typical symptoms of gastroesophageal reflux disease (GERD) are heartburn and regurgitation...
  6. ncbi The effect of dexlansoprazole MR on nocturnal heartburn and GERD-related sleep disturbances in patients with symptomatic GERD
    Ronnie Fass
    Southern Arizona VA Health Care System, Section of Gastroenterology 111G 1, Tucson, Arizona 85723, USA
    Am J Gastroenterol 106:421-31. 2011
    Nocturnal heartburn and related sleep disturbances are common among patients with gastroesophageal reflux disease (GERD)...
  7. ncbi Randomised clinical trial: a multicentre, double-blind, placebo-controlled study on the efficacy and safety of rabeprazole 5 mg or 10 mg once daily in patients with non-erosive reflux disease
    Y Kinoshita
    Department of Internal Medicine II, Shimane University, Izumo, Japan
    Aliment Pharmacol Ther 33:213-24. 2011
    ..The efficacy of rabeprazole 5 mg/day for patients with non-erosive reflux disease (NERD) has not been reported in the literature...
  8. ncbi Functional esophageal disorders
    Jean Paul Galmiche
    University of Nantes, Nantes, France
    Gastroenterology 130:1459-65. 2006
    Functional esophageal disorders represent processes accompanied by typical esophageal symptoms (heartburn, chest pain, dysphagia, globus) that are not explained by structural disorders, histopathology-based motor disturbances, or ..
  9. ncbi Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease
    David A Johnson
    Eastern Virginia Medical School, Division of Gastroenterology, Norfolk, 23505, USA
    Gastroenterology 126:660-4. 2004
    ..Although heartburn is the most common symptom of reflux disease, it is unclear whether the severity of heartburn reliably indicates ..
  10. ncbi Predictors of heartburn during sleep in a large prospective cohort study
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
    Chest 127:1658-66. 2005
    Nocturnal gastroesophageal reflux, which may result in nocturnal heartburn, has been demonstrated to be associated with a more severe form of gastroesophageal reflux disease (GERD)...
  11. ncbi Review article: the management of heartburn in pregnancy
    J E Richter
    Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Aliment Pharmacol Ther 22:749-57. 2005
    b>Heartburn is a normal consequence of pregnancy. The predominant aetiology is a decrease in lower oesophageal sphincter pressure caused by female sex hormones, especially progesterone...
  12. ncbi Association of heartburn during pregnancy with the risk of gastroesophageal reflux disease
    Serhat Bor
    Section of Gastroenterology, Ege University School of Medicine, Izmir, Turkey
    Clin Gastroenterol Hepatol 5:1035-9. 2007
    b>Heartburn and gastroesophageal reflux disease (GERD) during pregnancy are accepted as an innocent condition. The effect of heartburn during pregnancy on the initiation or progress of GERD is not known...
  13. pmc The effect of heartburn and acid reflux on the severity of nausea and vomiting of pregnancy
    Simerpal Kaur Gill
    The Motherisk Program, The Hospital for Sick Children University of Toronto, Toronto, Ontario, Canada
    Can J Gastroenterol 23:270-2. 2009
    b>Heartburn (HB) and acid reflux (RF) in the nonpregnant population can cause nausea and vomiting; therefore, it is plausible that in women with nausea and vomiting of pregnancy (NVP), HB/RF may increase the severity of symptoms.
  14. ncbi Demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors in the gastroesophageal reflux disease group
    Kwang Jae Lee
    Department of Gastroenterology, Ajou University School of Medicine, Suwon, South Korea
    Digestion 79:131-6. 2009
    The diagnostic criteria for nonerosive reflux disease (NERD) and functional heartburn (FH) have been changed...
  15. pmc Body-mass index and symptoms of gastroesophageal reflux in women
    Brian C Jacobson
    Boston University School of Medicine and Boston Medical Center, Boston, USA
    N Engl J Med 354:2340-8. 2006
    ..An association between body-mass index (BMI)--the weight in kilograms divided by the square of the height in meters - and symptoms of gastroesophageal reflux disease in persons of normal weight has not been demonstrated...
  16. ncbi The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups
    M Shapiro
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
    Aliment Pharmacol Ther 23:321-9. 2006
    ..Studies have demonstrated that patients with Barrett's oesophagus have the highest oesophageal acid exposure profile, followed by erosive oesophagitis and non-erosive reflux disease patients, but the exact extent of overlap remains unknown...
  17. ncbi Early heartburn relief with proton pump inhibitors: a systematic review and meta-analysis of clinical trials
    Kenneth R McQuaid
    Department of Medicine, University of California San Fransisco, CA, USA
    Clin Gastroenterol Hepatol 3:553-63. 2005
    Proton pump inhibitors (PPIs) are often taken for short-term treatment of heartburn. We performed a systematic review of the efficacy of PPIs for heartburn relief within the first 1-2 days of therapy.
  18. ncbi Predictors of heartburn resolution and erosive esophagitis in patients with GERD
    Roy C Orlando
    University of North Carolina Division of Gastroenterology and Hepatology, Chapel Hill, NC 27599 7032, USA
    Curr Med Res Opin 25:2091-102. 2009
    ..assess gastroesophageal reflux disease (GERD) symptom resolution rates with esomeprazole by erosive esophagitis (EE) status, and the secondary objective was to evaluate potential predictors of the presence of EE and heartburn resolution.
  19. ncbi Social and medical impact, sleep quality and the pharmaceutical costs of heartburn in Taiwan
    C L Lu
    Division of Gastroenterology, Taipei Veterans General Hospital, and School of Medicine, National Yang Ming University, Taipei, Taiwan
    Aliment Pharmacol Ther 22:739-47. 2005
    Little is known about the social and medical burdens of heartburn in Asia.
  20. ncbi Symptom-relieving effect of esomeprazole 40 mg daily in patients with heartburn
    F Johnsson
    Dept of Surgery, Lund University Hospital, Lund, Sweden
    Scand J Gastroenterol 38:347-53. 2003
    To assess symptom relief in patients with heartburn following treatment with esomeprazole 40 mg daily.
  21. ncbi Comparison of the different characteristics of sensed reflux events among different heartburn groups
    Ron Schey
    Section of Gastroenterology, Department of Medicine, The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care, Tucson, AZ, USA
    J Clin Gastroenterol 43:699-704. 2009
    Presently, there are no studies comparing sensed acid reflux event (SARE) characteristics among different heartburn groups...
  22. ncbi Psychometric validation of the Japanese translation of the Quality of Life in Reflux and Dyspepsia questionnaire in patients with heartburn
    Michio Hongo
    Department of Comprehensive Medicine, Tohoku University Hospital, 1 1 Seiryo machi, Aoba, Sendai 980 8574, Japan
    J Gastroenterol 42:807-15. 2007
    The purpose of this study was to document the psychometric characteristics of the Japanese translation of the Quality of Life in Reflux and Dyspepsia (QOLRAD-J) questionnaire in patients with heartburn.
  23. ncbi Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburn
    Edoardo Savarino
    Gastroenterology Unit, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Via Giustiniani, 2, 35121, Padua, Italy
    J Gastroenterol 48:473-82. 2013
    ..We aimed to compare these histological abnormalities in healthy volunteers (HVs) and patients with erosive esophagitis (EE), NERD, and functional heartburn (FH).
  24. ncbi Health state utilities in gastroesophageal reflux disease patients with heartburn: a study in Germany and Sweden
    Bernt Kartman
    AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    Med Decis Making 24:40-52. 2004
    ..of this study were to assess health state utilities in patients with gastroesophageal reflux disease with heartburn and to analyze if severity and annual frequency of heartburn can predict utilities...
  25. ncbi Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease
    Peter J Kahrilas
    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Clin Gastroenterol Hepatol 10:612-9. 2012
    ..We evaluated the responsiveness of regurgitation, characterized by the reflux disease questionnaire (RDQ) to potent acid suppression...
  26. ncbi Efficacy of rabeprazole on heartburn symptom resolution in patients with non-erosive and erosive gastro-oesophageal reflux disease: a multicenter study from Japan
    H Miwa
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Aliment Pharmacol Ther 26:69-77. 2007
    ..Few studies have compared the efficacy of proton pump inhibitors in resolving the symptoms of non-erosive reflux disease (NERD) and of erosive gastro-oesophageal reflux disease (GERD) in Japan...
  27. ncbi Nausea, vomiting, and heartburn in pregnancy: a prospective look at risk, treatment, and outcome
    Christopher R Naumann
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Matern Fetal Neonatal Med 25:1488-93. 2012
    To examine risk factors, treatment, and outcomes for nausea/vomiting (N/V) and heartburn during pregnancy.
  28. ncbi Pathophysiological characteristics of patients with non-erosive reflux disease differ from those of patients with functional heartburn
    M Frazzoni
    Divisione di Medicina Interna e Gastroenterologia, Ospedale S Agostino, Modena, Italy
    Aliment Pharmacol Ther 20:81-8. 2004
    Patients with endoscopy-negative heartburn can be subdivided into non-erosive reflux disease and functional heartburn on the basis of abnormal and normal, respectively, oesophageal acid exposure...
  29. ncbi Review article: management of mild and severe gastro-oesophageal reflux disease
    G N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 17:52-6. 2003
    ..Also poorly understood is the lower yield of complete heartburn relief when the number of associated dyspeptic symptoms is high...
  30. pmc Heartburn severity does not predict disease severity in patients with erosive esophagitis
    M Brian Fennerty
    Division of Gastroenterology, Oregon Health and Science University, Portland, Oregon, USA
    MedGenMed 8:6. 2006
    For patients with gastroesophageal reflux disease (GERD), it is often assumed by treating physicians that the severity of heartburn correlates with the severity of erosive esophagitis (EE).
  31. pmc Treatment of heartburn and acid reflux associated with nausea and vomiting during pregnancy
    Ruth Law
    Leslie DanFaculty of Pharmacy, University of Toronto, Toronto, Canada
    Can Fam Physician 56:143-4. 2010
    ..and vomiting of pregnancy, which is being treated with antiemetics, some of my pregnant patients complain of heartburn and acid reflux...
  32. ncbi Air swallowing can be responsible for non-response of heartburn to high-dose proton pump inhibitor
    P Zentilin
    Department of Internal Medicine, University of Genoa, Viale Benedetto XV, N 6, 16132 Genoa, Italy
    Dig Liver Dis 37:454-7. 2005
    ..She continued to complain of heartburn as major symptom and impedance allowed us to clarify that it was not related to acid or non-acid reflux, but to ..
  33. ncbi Patients with functional heartburn are more likely to report retrosternal discomfort during wireless pH monitoring
    Yi Chia Lee
    Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Gastrointest Endosc 62:834-41. 2005
    ..Although the wireless Bravo pH system is effective, some patients experience retrosternal sensations possibly caused by esophageal sensitivity that may complicate clinical application...
  34. ncbi Heartburn: cardiac potassium channels involved in parietal cell acid secretion
    Siegfried Waldegger
    Department of Paediatrics, University Hospital Marburg, Deutschhausstrasse 12, 35037, Marburg, Germany
    Pflugers Arch 446:143-7. 2003
    ....
  35. pmc Health-related quality of life improves with treatment-related GERD symptom resolution after adjusting for baseline severity
    Dennis A Revicki
    Center for Health Outcomes Research, MEDTAP International, Inc, Bethesda, Maryland, USA
    Health Qual Life Outcomes 1:73. 2003
    ..This study evaluated the association between baseline heartburn severity and endpoint HRQL of patients treated for heartburn and the relationship between complete resolution of ..
  36. ncbi Functional heartburn and non-erosive reflux disease
    Vincenzo Savarino
    Dipartimento di Medicina Interna e Specialita Mediche, Universita degli Studi di Genova, Genova, Italy
    Dig Dis 25:172-4. 2007
    ..are a heterogeneous group including various subpopulations with different mechanisms for their main symptom of heartburn: reflux of acidic and non-acidic gastric contents, mucosal hypersensitivity, intraesophageal distension by gas, ..
  37. ncbi Effects of antacid formulation on postprandial oesophageal acidity in patients with a history of episodic heartburn
    M Robinson
    Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Aliment Pharmacol Ther 16:435-43. 2002
    b>Heartburn self-treatment with antacids is extremely common. If the oesophagus is the primary site of antacid action, chewable antacids might raise the oesophageal pH more effectively than swallowable tablets.
  38. ncbi Increased frequency and enhanced perception of reflux in non-erosive reflux disease patients non-responders to proton pump inhibitors
    Mentore Ribolsi
    Department of Digestive Disease, University Campus Bio Medico, Rome, Italy
    Dig Liver Dis 44:549-54. 2012
    ..Non-responder patients, evaluated under treatment, present symptoms which are related to non-acidic, mixed and proximal reflux episodes...
  39. ncbi Heartburn and regurgitation in pregnancy: the effect of fat ingestion
    Valesca Dall'Alba
    Post Graduate Program, Sciences in Gastroenterology, School of Medicine and Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
    Dig Dis Sci 55:1610-4. 2010
    ..Reflux symptoms are common in pregnancy, but their association with fat ingestion is unclear...
  40. ncbi Effects of a single dose of rabeprazole 20 mg and pantoprazole 40 mg on 24-h intragastric acidity and oesophageal acid exposure: a randomized study in gastro-oesophageal reflux disease patients with a history of nocturnal heartburn
    P Miner
    Oklahoma Foundation for Digestive Research, Oklahoma City, OK, USA
    Aliment Pharmacol Ther 31:991-1000. 2010
    Nocturnal heartburn is common in patients with gastro-oesophageal reflux disease (GERD).
  41. ncbi Heartburn and related factors in general population in Tehran, capital of Iran
    A Safaee
    Research Center for Gastroenterology and Hepathology, 7th Floor, Taleghani Hospital, Chamran Highway, Tabnak St, Yaman Ave, Velenjak, Tehran, Iran
    East Afr J Public Health 7:196-8. 2010
    b>Heartburn is a highly prevalent disorder and is one of the most common gastrointestinal (GI) symptoms encountered in clinical practice...
  42. ncbi Heartburn: community perceptions
    T D Bolin
    The Gut Foundation, Prince of Wales Hospital, Randwick, New South Wales, Australia
    J Gastroenterol Hepatol 15:35-9. 2000
    To determine the prevalence of heartburn in the Australian community, and document factors precipitating it and medications used in treatment.
  43. ncbi Clinical trial: factors associated with resolution of heartburn in patients with reflux oesophagitis--results from the EXPO study
    J Labenz
    Medical Department, Ev Jung Stilling Hospital, Siegen, Germany
    Aliment Pharmacol Ther 29:959-66. 2009
    ..The ability to predict symptom response to reflux oesophagitis-healing therapy may optimize treatment decisions...
  44. ncbi Cost-effectiveness and cost-utility of long-term management strategies for heartburn
    Ron Goeree
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 1G6, Canada
    Value Health 5:312-28. 2002
    To compare the expected costs and outcomes of seven alternative long-term primary care strategies for the management of patients with moderate-to-severe heartburn over a 1-year period.
  45. ncbi Functional heartburn: what it is and how to treat it
    Ronnie Fass
    Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, GI Section 1 111G 1, 3601 South 6th Avenue, Tucson, AZ 85723 0001, USA
    Gastrointest Endosc Clin N Am 19:23-33, v. 2009
    Functional heartburn is considered one of the most common functional esophageal disorders...
  46. ncbi Clinical trial: factors associated with freedom from relapse of heartburn in patients with healed reflux oesophagitis--results from the maintenance phase of the EXPO study
    J Labenz
    Medical Department, Ev Jung Stilling Hospital, Siegen, Germany
    Aliment Pharmacol Ther 29:1165-71. 2009
    Ability to predict freedom from heartburn relapse during maintenance therapy for healed reflux oesophagitis may facilitate optimal treatment choices for individual patients.
  47. ncbi Heartburn: another danger in the night?
    William C Orr
    Chest 127:1486-8. 2005
  48. ncbi Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugs
    C J Hawkey
    Institute of Clinical Research Trials Unit, University Hospital, Nottingham, UK
    Aliment Pharmacol Ther 25:813-21. 2007
    The use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal symptoms such as heartburn and acid regurgitation.
  49. ncbi Erosive esophagitis and NERD: Can we really classify patients with heartburn by endoscopic findings?
    William D Chey
    Clin Gastroenterol Hepatol 2:654-5. 2004
  50. ncbi Body mass index, chronic atrophic gastritis and heartburn: a population-based study among 8936 older adults from Germany
    L Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Baden Wurttemberg, Germany
    Aliment Pharmacol Ther 32:296-302. 2010
    ..It has been suggested that this relationship is as a consequence of an increased gastric acid reflux, which is caused by an enhanced intra-abdominal pressure...
  51. ncbi The effect of life stress on symptoms of heartburn
    Bruce D Naliboff
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, Los Angeles, CA, USA
    Psychosom Med 66:426-34. 2004
    ..The present longitudinal study tests the general hypothesis that life stressors can exacerbate symptoms in patients with chronic heartburn.
  52. ncbi Refractory heartburn to proton pump inhibitors: epidemiology, etiology and management
    Spiros N Sgouros
    Department of Gastroenterology, Athens Naval Hospital, GR 15341 Athens, Greece
    Digestion 73:218-27. 2006
    Patients with refractory heartburn to proton pump inhibitors (PPIs) represent a distinctive group which is difficult to manage...
  53. ncbi Serum lipid levels are positively associated with non-erosive reflux disease, but not with functional heartburn
    J Matsuzaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Neurogastroenterol Motil 22:965-70, e251. 2010
    ..Although non-erosive reflux disease (NERD) is probably associated with obesity or other metabolic syndrome, there is little direct evidence to support this assertion...
  54. ncbi Modulation of salivation and heartburn in response to the site of acid infusion in the human oesophagus
    S K Dutta
    Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Aliment Pharmacol Ther 32:795-800. 2010
    ..This may depend upon the height of acid wave and magnitude of oesophageal mucosal exposure. Interestingly, the effect of site of acid infusion upon salivary secretion and heartburn has not been examined in any detail.
  55. ncbi Sleep issues in gastroesophageal reflux disease: beyond simple heartburn control
    William C Orr
    Lynn Health Science Institute, Oklahoma City, Oklahoma, USA
    Rev Gastroenterol Disord 3:S22-9. 2003
    ..Nocturnal GER can lead to the development of esophagitis and other extra esophageal complications, such as exacerbation of asthmatic symptoms...
  56. ncbi Comparison of objective outcomes following laparoscopic Nissen fundoplication versus laparoscopic gastric bypass in the morbidly obese with heartburn
    E J Patterson
    Department of Minimally Invasive Surgery, Legacy Health System, 501 North Graham Street, Suite 120, Portland, OR 97227, USA
    Surg Endosc 17:1561-5. 2003
    b>Heartburn and gastroesophageal reflux disease (GERD) affects approximately 25-50% of morbidly obese patients...
  57. pmc Prevalence of acid reflux in functional dyspepsia and its association with symptom profile
    J Tack
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Gut 54:1370-6. 2005
    ..The aim of the present study was to study 24 hour pH monitoring in consecutive functional dyspepsia patients...
  58. ncbi Sustained esophageal contraction: a motor correlate of heartburn symptom
    N Pehlivanov
    Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Gastrointest Liver Physiol 281:G743-51. 2001
    b>Heartburn occurs in the presence as well as the absence of acid reflux. We searched for a motor correlate of heartburn...
  59. ncbi Validation of a symptom diary for patients with gastro-oesophageal reflux disease
    M A Puhan
    Horten Centre, University of Zurich, Switzerland
    Aliment Pharmacol Ther 23:531-41. 2006
    ..We assessed the validity and responsiveness of a symptom diary for patients with gastro-oesophageal reflux disease...
  60. ncbi Does short-term treatment with proton pump inhibitors cause rebound aggravation of symptoms?
    P G Farup
    Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway
    J Clin Gastroenterol 33:206-9. 2001
    ..Rebound acid hypersecretion might occur after treatment with proton pump inhibitors. This study looks for a rebound aggravation of symptoms after short-term treatment with lansoprazole...
  61. ncbi An open-label, multicentre study to assess the safety and efficacy of a novel reflux suppressant (Gaviscon Advance) in the treatment of heartburn during pregnancy
    S W Lindow
    University of Hull, Hull, UK
    Int J Clin Pract 57:175-9. 2003
    ..study investigated the efficacy and safety of a novel reflux suppressant, Gaviscon Advance, in the treatment of heartburn during pregnancy...
  62. ncbi Characterization of the cerebral cortical representation of heartburn in GERD patients
    Mark Kern
    Medical College of Wisconsin Dysphagia Institute, Division of Gastroenterology and Hepatology, Digestive Disease Center, Biophysics Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Gastrointest Liver Physiol 286:G174-81. 2004
    Although symptoms arising from the esophagus such as heartburn and pain can at times become challenging clinical problems, esophageal viscerosensation, especially with regard to chemical stimulation in humans, is incompletely understood...
  63. ncbi The pathogenesis of heartburn in nonerosive reflux disease: a unifying hypothesis
    William J Barlow
    Tulane University Health Sciences Center, Department of Medicine SL 35, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
    Gastroenterology 128:771-8. 2005
    b>Heartburn is a symptom complex that has traditionally been accepted as an acid-mediated event and a reliable indicator of gastroesophageal reflux disease...
  64. ncbi Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapy
    Christina Reimer
    Department of Medical Gastroenterology, Køge University Hospital, Copenhagen University, Copenhagen, Denmark
    Gastroenterology 137:80-7, 87.e1. 2009
    ..Rebound acid hypersecretion (RAHS) has been demonstrated after 8 weeks of treatment with a proton-pump inhibitor (PPI). If RAHS induces acid-related symptoms, this might lead to PPI dependency and thus have important implications...
  65. ncbi The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease
    Edoardo Savarino
    Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, Italy Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Milan, Italy
    Dig Liver Dis 43:542-7. 2011
    Functional heartburn is defined by Rome III criteria as an endoscopy-negative condition with normal oesophageal acid exposure time, negative symptom association to acid reflux and unsatisfactory response to proton pump inhibitors...
  66. ncbi Heartburn in Belgium: prevalence, impact on daily life, and utilization of medical resources
    Edouard Louis
    Gastroenterology Department, CHU of Liege, Brussels, Belgium
    Eur J Gastroenterol Hepatol 14:279-84. 2002
    ..The specificity of heartburn for the diagnosis of GORD is good...
  67. ncbi Heartburn-dominant, uninvestigated dyspepsia: a comparison of 'PPI-start' and 'H2-RA-start' management strategies in primary care--the CADET-HR Study
    D Armstrong
    Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
    Aliment Pharmacol Ther 21:1189-202. 2005
    There are few data on empiric, stepped therapy for heartburn relief or subsequent relapse in primary care.
  68. ncbi Treatment of patients with persistent heartburn symptoms: a double-blind, randomized trial
    Ronnie Fass
    The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723 0001, USA
    Clin Gastroenterol Hepatol 4:50-6. 2006
    ..2 therapeutic strategies, increasing the proton pump inhibitor dosage to twice daily versus switching to another proton pump inhibitor, in patients with persistent heartburn while receiving standard-dose proton pump inhibitor therapy.
  69. ncbi Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association
    Reza Shaker
    Medical College of Wisconsin Dysphagia Institute, Division of Gastroenterology and Hepatology, Milwaukee, Wisconsin, USA
    Am J Gastroenterol 98:1487-93. 2003
    ..as well as adenocarcinoma of the esophagus, a better understanding of the prevalence and impact of nighttime heartburn as a sign of nocturnal acid reflux events can have significant potential management implications...
  70. ncbi Helicobacter pylori infection in patients with erosive esophagitis is associated with rapid heartburn relief and lack of relapse after treatment with pantoprazole
    José L Calleja
    Recordati España, Scientific Research Department, Spain
    Dig Dis Sci 50:432-9. 2005
    ..Healing and symptom relief rates for HP infection were compared. We found complete relief of heartburn in 72.3% of the HP-positive versus 58.8% of the HP-negative group (P < 0.05)...
  71. ncbi Endoscopic and histologic findings in Iranian patients with heartburn
    Yousef Bafandeh
    Department of Gastroenterology, Tabriz University of Medical Sciences, Tabriz, Iran
    Indian J Gastroenterol 24:236-8. 2005
    b>Heartburn is a common manifestation of gastroesophageal reflux disease. Barrett's esophagus and esophageal adenocarcinoma, known complications of this disease, appear to be less prevalent in Asia than in Western countries...
  72. ncbi Quantitative assessment and characterization of visceral hyperalgesia evoked by esophageal balloon distention and acid perfusion in patients with functional heartburn, nonerosive reflux disease, and erosive esophagitis
    Min Yang
    Department of Gastroenterology, Daping Hospital, Chongqing, China
    Clin J Pain 26:326-31. 2010
    The role of esophageal hypersensitivity in functional heartburn (FH) with negative pH test, negative symptom index, and the proton pump inhibitor (PPI) failure has not been established...
  73. ncbi Recurrent symptoms after fundoplication with a negative pH study--recurrent reflux or functional heartburn?
    Sarah K Thompson
    Discipline of Surgery, University of Adelaide, Adelaide, South Australia, Australia
    J Gastrointest Surg 13:54-60. 2009
    A small cohort of patients present after antireflux surgery complaining of recurrent heartburn. Over two thirds of these patients will have a negative 24-h pH study...
  74. ncbi Heartburn during sleep: a clinical marker of gastro-oesophageal reflux disease in morbidly obese patients
    F Fornari
    Laboratory of Oesophageal Motility, ENDOPASSO, Passo Fundo RS, Brazil
    Neurogastroenterol Motil 21:136-42. 2009
    ..The aim of this study was to assess the prevalence of heartburn during sleep (HDS) and whether this symptom predicts the presence of objective GORD parameters and increased ..
  75. ncbi Functional heartburn patients demonstrate traits of functional bowel disorder but lack a uniform increase of chemoreceptor sensitivity to acid
    Michael Shapiro
    The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723 0001, USA
    Am J Gastroenterol 101:1084-91. 2006
    Functional heartburn (FH) patients have a profound impact on the response to anti-reflux therapy of the nonerosive reflux disease (NERD) group as compared to the response of the erosive esophagitis group...
  76. ncbi Review article: the role of acid suppression in patients with non-erosive reflux disease or functional heartburn
    K R Devault
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Jacksonville, FL 32233, USA
    Aliment Pharmacol Ther 23:33-9. 2006
    When patients with the typical reflux symptoms of heartburn, regurgitation, or both, undergo endoscopy, up to 75% will not have endoscopic oesophagitis or evidence of Barrett's oesophagus...
  77. ncbi Esophageal visceral sensitivity to bile salts in patients with functional heartburn and in healthy control subjects
    Ali Siddiqui
    Oklahoma Foundation for Digestive Research, Oklahoma City, Oklahoma 73104, USA
    Dig Dis Sci 50:81-5. 2005
    ..We have demonstrated that gastric contents can cause heartburn when the gastric pH >4. (Aliment Pharm Ther 14:129-134, 2000)...
  78. ncbi Beyond heartburn: a systematic review of the extra-oesophageal spectrum of reflux-induced disease
    A Pali S Hungin
    Cetre for Integrated Health Care Research, University of Durham Stockton Campus, Wolfson Research Institute, Stockton on Tees TS176BH, UK
    Fam Pract 22:591-603. 2005
    ..GORD is characterized by heartburn and acid regurgitation, but is reported to be associated with a spectrum of extra-oesophageal symptoms.
  79. ncbi Heartburn in primary care: problems below the surface
    Gerald Holtmann
    Division of Internal Medicine, Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    J Gastroenterol 39:1027-34. 2004
    b>Heartburn is a common physiological event often associated with an underlying occurrence of gastroesophageal reflux disease (GERD)...
  80. pmc Determinants of perception of heartburn and regurgitation
    A J Bredenoord
    Department of Gastroenterology, St Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, and Gastrointestinal Research Centre, University Medical Centre, Utrecht, The Netherlands
    Gut 55:313-8. 2006
    ..It is not known why some reflux episodes evoke symptoms and others do not. We investigated the determinants of perception of gastro-oesophageal reflux...
  81. ncbi [Nationwide epidemiological survey regarding heartburn and reflux esophagitis in Japanese]
    Syuichi Ohara
    The Health Administration Center, Tohoku University
    Nihon Shokakibyo Gakkai Zasshi 102:1010-24. 2005
    The details on prevalence of heartburn and reflux esophagitis have not been clarified, since no large-scale survey has been conducted to date...
  82. ncbi Prevalence of heartburn and gastroesophageal reflux disease in the urban Brazilian population
    Joaquim Prado P Moraes-Filho
    Department of Gastroenterology, Faculty of Medicine, Clinics Hospital, University of Sao Paulo, Brazil
    Arq Gastroenterol 42:122-7. 2005
    The epidemiological aspects of heartburn and gastroesophageal reflux disease have been object of growing interest in the last decade because of its increasing prevalence and the complications of the disease.
  83. pmc Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project
    Richard F Harvey
    Frenchay Hospital, North Bristol NHS Trust, Bristol BS16 1LE
    BMJ 328:1417. 2004
    To investigate the effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux.
  84. ncbi Comparing lansoprazole and omeprazole in onset of heartburn relief: results of a randomized, controlled trial in erosive esophagitis patients
    J E Richter
    Department of Gastroenterology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 96:3089-98. 2001
    ..double-blind, multicenter study was conducted to confirm a previous finding that lansoprazole relieves heartburn faster than omeprazole in patients with erosive esophagitis...
  85. ncbi Association of body mass index with heartburn, regurgitation and esophagitis: results of the Progression of Gastroesophageal Reflux Disease study
    Marc Nocon
    Institute for Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
    J Gastroenterol Hepatol 22:1728-31. 2007
    ..The aim of the present study was to analyze the impact of body mass index (BMI) on the severity and frequency of reflux symptoms and esophagitis in a large cohort of reflux patients...
  86. ncbi Management of heartburn in a large, randomized, community-based study: comparison of four therapeutic strategies
    C W Howden
    Northwestern University Medical School, Chicago, Illinois, USA
    Am J Gastroenterol 96:1704-10. 2001
    OBJECTIVE: Our objective was to compare four management strategies for heartburn: therapy with an H2-receptor antagonist (ranitidine), therapy with a proton pump inhibitor (lansoprazole), crossover from ranitidine to lansoprazole ("..
  87. ncbi Quality of life in patients with endoscopy-negative heartburn: reliability and sensitivity of disease-specific instruments
    N J Talley
    Department of Medicine, The University of Sydney, The Nepean Hospital, Penrith, Australia
    Am J Gastroenterol 96:1998-2004. 2001
    ..METHODS: Patients (n = 1143) with heartburn, but no esophagitis included in a randomized clinical trial assessing the effectiveness of active treatment with ..
  88. ncbi Functional heartburn vs. non-erosive reflux disease: similarities and differences
    T Hershcovici
    Gastroenterology Unit, Hadassah Hebrew University Medical Centre, Jerusalem, Israel
    Aliment Pharmacol Ther 27:1103-9. 2008
    Bowel symptoms have been associated with non-erosive reflux disease (NERD). However, their role in functional heartburn (FH) has not been established.
  89. ncbi Differences in recognition of heartburn symptoms between Japanese patients with gastroesophageal reflux, physicians, nurses, and healthy lay subjects
    Noriaki Manabe
    Division of Endoscopy and Ultrasonography, Kawasaki Medical School, Kurashiki, Japan
    Scand J Gastroenterol 43:398-402. 2008
    Patients who complain of "heartburn" to their general practitioner tend to use the word to indicate a variety of symptoms...
  90. ncbi Clinical trial: efficacy and safety of dexlansoprazole MR 60 and 90 mg in healed erosive oesophagitis - maintenance of healing and symptom relief
    C W Howden
    Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Aliment Pharmacol Ther 30:895-907. 2009
    ..Dexlansoprazole MR, a modified-release formulation of dexlansoprazole, an enantiomer of lansoprazole, effectively heals erosive oesophagitis...
  91. ncbi Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man
    S Kindt
    Department of Pathophysiology, Center for Gastroenterological Research, K U Leuven, Belgium
    Neurogastroenterol Motil 21:1032-e82. 2009
    b>Heartburn is the most typical gastro-oesophageal reflux disease (GERD) symptom. The transient receptor potential vanilloid receptor-1 (TRPV(1)) is a candidate mediator of heartburn...
  92. ncbi Mechanisms of heartburn
    Daphne Ang
    Department of Gastroenterology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Nat Clin Pract Gastroenterol Hepatol 5:383-92. 2008
    b>Heartburn is a typical symptom of GERD. The spectrum of diseases associated with GERD includes reflux esophagitis, Barrett's esophagus and nonerosive reflux disease (NERD)...
  93. ncbi Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis
    Donald O Castell
    Department of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston 29425, USA
    Am J Gastroenterol 97:575-83. 2002
    ..This study compared esomeprazole with lansoprazole for the healing of erosive esophagitis and resolution of heartburn.
  94. ncbi Clinical trial: the effects of the proton pump inhibitor dexlansoprazole MR on daytime and nighttime heartburn in patients with non-erosive reflux disease
    R Fass
    Section of Gastroenterology, University of Arizona Health Science Center and Southern Arizona VA Health Care System, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 29:1261-72. 2009
    ..The proportion of patients who respond to proton pump inhibitor (PPI) therapy is about 20% lower in those with non-erosive reflux disease (NERD) than in those with erosive oesophagitis...
  95. ncbi Pantoprazole rapidly improves health-related quality of life in patients with heartburn: a prospective, randomized, double blind comparative study with nizatidine
    Pierre Pare
    Hôpital St Sacrement, Division of Gastroenterology, 1050, Chemin Ste Foy, Quebec G1S 4L8, Canada
    J Clin Gastroenterol 37:132-8. 2003
    ..In the absence of an objective marker such as erosions, assessment of treatment efficacy can be based on symptoms and HRQoL...
  96. ncbi Factor structure of the Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire evaluated in patients with heartburn predominant reflux disease
    Károly R Kulich
    AstraZeneca R and D Molndal, Molndal, Sweden
    Qual Life Res 12:699-708. 2003
    ..To test whether the original factor structure of the Quality of Life in Reflux and Dyspepsia (QOLRAD) can be replicated in Nordic patients and English speaking patients...
  97. ncbi Sufficient control of heartburn in endoscopy-negative gastro-oesophageal reflux disease trials
    O Junghard
    Dept of Clinical Science, AstraZeneca R and D Molndal, Sweden
    Scand J Gastroenterol 38:1197-9. 2003
  98. pmc Functional heartburn: the stimulus, the pain, and the brain
    R Fass
    Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723, USA
    Gut 51:885-92. 2002
    Functional heartburn is a common disorder and appears to be composed of several distinct subgroups. Identifying the different subgroups based on clinical history only is not achievable at present...
  99. ncbi Lansoprazole in the treatment of heartburn in patients without erosive oesophagitis
    J E Richter
    The Cleveland Clinic, Cleveland, OH 44195, USA
    Aliment Pharmacol Ther 13:795-804. 1999
    ..This randomized, double-blind, multicentre study compared lansoprazole with placebo for symptomatic relief of patients with non-erosive gastro-oesophageal reflux disease (GERD)...
  100. ncbi Complete resolution of heartburn symptoms and health-related quality of life in patients with gastro-oesophageal reflux disease
    D A Revicki
    Center for Health Outcomes Research, MEDTAP International, Bethesda, MD 20814, USA
    Aliment Pharmacol Ther 13:1621-30. 1999
    Medical treatments for gastro-oesophageal reflux disease (GERD) vary in their ability to completely resolve heartburn and other symptoms...
  101. ncbi Esomeprazole resolves chronic heartburn in patients without erosive oesophagitis
    P O Katz
    Department of Gastroenterology, Albert Einstein Medical Center, Philadelphia, PA 19141, USA
    Aliment Pharmacol Ther 18:875-82. 2003
    Patients with chronic heartburn but with no endoscopic evidence of erosive oesophagitis require gastric acid suppression to relieve symptoms.

Research Grants44

  1. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2013
    ..Gastrointestinal motility disorders result in a variety of diseases that cause difficulty in swallowing, heartburn, dyspepsia, constipation and chronic abdominal pain...
  2. Gastroesophageal Antireflux Mechanisms
    MICHAEL RAYMOND RUGGIERI; Fiscal Year: 2013
    ..Problems associated with GERD include the minor inconveniences of heartburn to the lethal complications of aspirational pneumonia in infancy and esophageal adenocarcinoma in adulthood...
  3. Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall Ischemia
    Ravinder K Mittal; Fiscal Year: 2013
    ..manometery we found a unique "sustained esophageal contraction (SEC)" in association with esophageal pain and heartburn in the late 90's...
  4. Epidemiology and Pathophysiology of Reflux Disease in African Americans
    Frank K Friedenberg; Fiscal Year: 2013
    ..applicant): This research will help doctors to understand the frequency and risks for esophageal reflux disease (heartburn) in African Americans. The role of obesity and weight loss in the treatment of reflux will be clarified...
  5. Esophageal Adenocarcinoma Policy Model: Trends, Risk Factors and Screening
    Chin Hur; Fiscal Year: 2013
    ..b>Heartburn, the primary symptom of gastroesophageal reflux disease (GERD), affects 60 million Americans and can lead to ..
  6. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2012
    Project Summary Esophageal adenocarcinoma (EA), the type of cancer linked to heartburn due to gastroesophageal reflux diseases (GERD), has increased six fold in the past 30 years, which can not be explained by the usual environmental or ..
  7. ESOPHAGEAL CYTOPROTECTION--AGENTS AND MECHANISMS
    Roy Orlando; Fiscal Year: 2009
    ..Since localization to the ICJs is key to validating our proposed pathogenesis of heartburn and esophagitis, another goal is to confirm, using in vivo PD measurements during salt superfusions, that this ..
  8. ESOPHAGEAL MOTOR FUNCTION IN HEALTH AND DISEASE
    REZA NONE SHAKER; Fiscal Year: 2012
    ..It is estimated that 7-10% of US population suffers daily from heartburn the cardinal symptom of GERD which negatively impacts the quality of life, work productivity and health care ..
  9. ESOPHAGEAL MOTOR FUNCTION IN HEALTH AND DISEASE
    REZA NONE SHAKER; Fiscal Year: 2013
    ..While mucosal injury in GERD responds adequately to medical therapy, remedying the GERD symptoms such as heartburn and sensation/awareness of the refluxate movement within the esophagus referred to as regurgitation movement ..
  10. Controlling Esophageal Cancer in the US.: A Colloraborative Modeling Project
    GEORG E LUEBECK; Fiscal Year: 2013
    ..b>Heartburn, the primary symptom of gastroesophageal reflux disease (GERD), affects 60 million Americans and can lead to ..
  11. Esophageal Mast Cell Nerve Interactions
    Shaoyong Yu; Fiscal Year: 2013
    Abnormal esophageal sensations, such as esophageal-related noncardiac chest pain and heartburn, are common complaints. The underlying mechanism of such esophageal nociception remains unclear...
  12. Foregut microbiome in development of esophageal adenocarcinoma
    Zhiheng Pei; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Esophageal adenocarcinoma (EA), the type of cancer linked to heartburn due to gastroesophageal reflux diseases (GERD), has increased six fold in the past 30 years, which cannot be explained by the ..
  13. SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEM
    KATHY LEPARD; Fiscal Year: 2001
    ..Diabetic patients often experience a wide range of GI discomforts including heartburn, nausea, vomiting, diarrhea, constipation, fecal incontinence and abdominal pain...
  14. The Prevalence of Barrett's Esophagus in Patients with *
    Blair Jobe; Fiscal Year: 2004
    ..The prevalence of GERD-related esophageal injury in patients with isolated extraesophageal symptoms (i.e., no heartburn or regurgitation) is unknown...
  15. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2003
    ..Barrett's esophagus is a pre-malignant condition that is produced by gastroesophageal reflux disease (heartburn)...
  16. NOVEL ERYTHROMYCIN ANALOGS FOR GI MOTILITY DISORDERS
    Christopher Carreras; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATIONS: The ideal motilide will be a safe and effective treatment for common heartburn. Motilides are anticipated to have applications for the treatment of diabetic gastroparesis, postoperative ileus ..
  17. The Prevention of Esophageal Adenocarcinoma
    Chin Hur; Fiscal Year: 2009
    ..to the alarming increase in the incidence of esophageal adenocarcinoma in the last two decades, patients with heartburn or reflux symptoms are increasingly undergoing endoscopic evaluation...
  18. Medical and Surgical Treatment of Esophageal Reflux
    Samuel Finlayson; Fiscal Year: 2003
    ..Approximately 75 million Americans suffer from "heartburn", the most typical symptom of GERD...
  19. Barrett's Esophagus: Risk Factors in Women
    Douglas Corley; Fiscal Year: 2009
    ..It is estimated that 10% of those with chronic heartburn harbor BE, and approximately 25% of subjects with BE are women...
  20. Prevention of reflux-induced esophageal adenocarcimona by dietary berries
    Robert Martin; Fiscal Year: 2009
    ..BE is caused by chronic heartburn, which affects more than 19 million Americans every year...
  21. LASER CATHETER FOR TREATMENT OF GASTROESOPHAGEAL REFLUX
    Ashok Gowda; Fiscal Year: 2001
    ..PROPOSED COMMERCIAL APPLICATION: It is estimated that 33% of the adult population experience heartburn at least once a month and approximately 14 million Americans, or 7% of the adult population, suffer from ..
  22. Surveillance for Hepatocellular Carcinoma among HCV-infected Veterans
    Hashem El Serag; Fiscal Year: 2009
    ..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
  23. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  24. ROLE OF PUBORECTALIS MUSCLE IN FECAL CONTINENCE
    RAVINDER MITTAL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. Comparison of Two Therapies for UES Dysphagia
    Reza Shaker; Fiscal Year: 2004
    ..anteroposterior and lateral diameter of maximum deglutitive UES opening, and b. maximum deglutitive laryngeal anterior and superior excursions. ..
  26. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  27. PHARYNGEAL RECEPTORS AND REFLUX DISEASE
    RAVINDER MITTAL; Fiscal Year: 2001
    ..Effects of atropine on the frequency of TLESR and GER in patients with reflux esophagitis. ..
  28. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  29. Predicting CHD Events in Black and White Women
    Jean C McSweeney; Fiscal Year: 2010
    ..We also will explore the correspondence between the MAPMISS screen scores and CHD diagnostic test results. ..
  30. Barrett's Esophagus Ablation with Celocoxib Trial
    Charles Lightdale; Fiscal Year: 2002
    ..Patients will be accrued during the first study year, and will be followed until the last patient enrolled completes one year of treatment. ..
  31. Treatment of Fear and Pain in Irritable Bowel Syndrome
    Bruce Naliboff; Fiscal Year: 2006
    ..abstract_text> ..
  32. MITOCHONDRIAL ROLE IN CASPASE PROCESSING AND ACTIVATION
    Roberta Gottlieb; Fiscal Year: 2003
    ..Understanding these fundamental processes in the comparatively simple and easily manipulated system of Jurkat cells and Fas-mediated apoptosis can be readily translated to studies in the heart. ..
  33. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2003
    ..abstract_text> ..
  34. Cohort Study of Nitrate Exposure, MHG, and Health
    Catherine Zeman; Fiscal Year: 2004
    ..of nitrate/nitrite containing waters and the overall health effects as they may reflect on the current maximum contaminant level, MCL of 10 ppm (mg/I) nitrate/nitrogen, a level that was set without consideration of a safety factor ..
  35. Quantitative Approach to Analysis of Cortical Dynamics
    Hualou Liang; Fiscal Year: 2005
    ..abstract_text> ..
  36. The Epidemiology of Barrett's Esophagus in Children
    Mark Gilger; Fiscal Year: 2005
    ....
  37. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  38. Cytochrome P450 in Reperfusion Injury
    Roberta Gottlieb; Fiscal Year: 2007
    ..This proposal identifies cytochrome P450 monooxygenases as a previously underestimated factor in myocardial reperfusion injury, and establishes the basis for a novel therapeutic approach [unreadable] [unreadable]..
  39. Bid-Mediated Cytochrome c Release from Mitochondria
    Roberta Gottlieb; Fiscal Year: 2007
    ..These studies will elucidate the molecular mechanism by which BH3-only proteins cause the release of cytochrome c from mitochondria. [unreadable] [unreadable]..
  40. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  41. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2008
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  42. Use of Quantitative RT-PCR for Staging Esophageal Cancer
    James Luketich; Fiscal Year: 2009
    ..In addition, we believe that this research will answer some very interesting questions about tumor biology and metastasis in esophageal cancer. ..
  43. MI SYMPTOMS IN WOMEN: DISPARITIES IN WOMEN OF COLOR
    Jean McSweeney; Fiscal Year: 2002
    ..This information will facilitate the development of educational materials tailored to women of color and should lead to earlier diagnosis and treatment. ..