Genomes and Genes
Summary: Substernal pain or burning sensation, usually associated with regurgitation of gastric juice into the esophagus.
Publications275 found, 100 shown here
- Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux diseaseE Savarino
Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, Italy
Gut 58:1185-91. 2009..Still, patients with NERD represent a very heterogeneous group and limited data on dyspeptic symptoms in various subgroups of NERD are available...
- Time trends of gastroesophageal reflux disease: a systematic reviewHashem B El-Serag
Gastroenterology and Health Services Research Sections, Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Clin Gastroenterol Hepatol 5:17-26. 2007..First, population-based studies that reported the prevalence of at least weekly heartburn and/or acid regurgitation were subjected to a time-trend analysis with a Poisson regression model...
- Management of heartburn not responding to proton pump inhibitorsR Fass
The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care System, Tucson, Arizona 85723 0001, USA
Gut 58:295-309. 2009..These include weakly acidic reflux, duodenogastro-oesophageal reflux, residual acid reflux and functional heartburn, as well as others...
- Screening for Barrett's esophagus in colonoscopy patients with and without heartburnDouglas K Rex
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
Gastroenterology 125:1670-7. 2003..The population prevalence of Barrett's esophagus (BE) is uncertain. Our aim was to describe the prevalence of BE in a volunteer population...
- Response of regurgitation to proton pump inhibitor therapy in clinical trials of gastroesophageal reflux diseasePeter J Kahrilas
Division of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 2951, USA
Am J Gastroenterol 106:1419-25; quiz 1426. 2011The typical symptoms of gastroesophageal reflux disease (GERD) are heartburn and regurgitation...
- The effect of dexlansoprazole MR on nocturnal heartburn and GERD-related sleep disturbances in patients with symptomatic GERDRonnie Fass
Southern Arizona VA Health Care System, Section of Gastroenterology 111G 1, Tucson, Arizona 85723, USA
Am J Gastroenterol 106:421-31. 2011Nocturnal heartburn and related sleep disturbances are common among patients with gastroesophageal reflux disease (GERD)...
- Randomised clinical trial: a multicentre, double-blind, placebo-controlled study on the efficacy and safety of rabeprazole 5 mg or 10 mg once daily in patients with non-erosive reflux diseaseY Kinoshita
Department of Internal Medicine II, Shimane University, Izumo, Japan
Aliment Pharmacol Ther 33:213-24. 2011..The efficacy of rabeprazole 5 mg/day for patients with non-erosive reflux disease (NERD) has not been reported in the literature...
- Functional esophageal disordersJean Paul Galmiche
University of Nantes, Nantes, France
Gastroenterology 130:1459-65. 2006Functional esophageal disorders represent processes accompanied by typical esophageal symptoms (heartburn, chest pain, dysphagia, globus) that are not explained by structural disorders, histopathology-based motor disturbances, or ..
- Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux diseaseDavid A Johnson
Eastern Virginia Medical School, Division of Gastroenterology, Norfolk, 23505, USA
Gastroenterology 126:660-4. 2004..Although heartburn is the most common symptom of reflux disease, it is unclear whether the severity of heartburn reliably indicates ..
- Predictors of heartburn during sleep in a large prospective cohort studyRonnie Fass
Section of Gastroenterology, Department of Medicine, Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
Chest 127:1658-66. 2005Nocturnal gastroesophageal reflux, which may result in nocturnal heartburn, has been demonstrated to be associated with a more severe form of gastroesophageal reflux disease (GERD)...
- Review article: the management of heartburn in pregnancyJ E Richter
Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
Aliment Pharmacol Ther 22:749-57. 2005b>Heartburn is a normal consequence of pregnancy. The predominant aetiology is a decrease in lower oesophageal sphincter pressure caused by female sex hormones, especially progesterone...
- Association of heartburn during pregnancy with the risk of gastroesophageal reflux diseaseSerhat Bor
Section of Gastroenterology, Ege University School of Medicine, Izmir, Turkey
Clin Gastroenterol Hepatol 5:1035-9. 2007b>Heartburn and gastroesophageal reflux disease (GERD) during pregnancy are accepted as an innocent condition. The effect of heartburn during pregnancy on the initiation or progress of GERD is not known...
- The effect of heartburn and acid reflux on the severity of nausea and vomiting of pregnancySimerpal Kaur Gill
The Motherisk Program, The Hospital for Sick Children University of Toronto, Toronto, Ontario, Canada
Can J Gastroenterol 23:270-2. 2009b>Heartburn (HB) and acid reflux (RF) in the nonpregnant population can cause nausea and vomiting; therefore, it is plausible that in women with nausea and vomiting of pregnancy (NVP), HB/RF may increase the severity of symptoms.
- Demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors in the gastroesophageal reflux disease groupKwang Jae Lee
Department of Gastroenterology, Ajou University School of Medicine, Suwon, South Korea
Digestion 79:131-6. 2009The diagnostic criteria for nonerosive reflux disease (NERD) and functional heartburn (FH) have been changed...
- Body-mass index and symptoms of gastroesophageal reflux in womenBrian C Jacobson
Boston University School of Medicine and Boston Medical Center, Boston, USA
N Engl J Med 354:2340-8. 2006..An association between body-mass index (BMI)--the weight in kilograms divided by the square of the height in meters - and symptoms of gastroesophageal reflux disease in persons of normal weight has not been demonstrated...
- The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groupsM Shapiro
The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723 0001, USA
Aliment Pharmacol Ther 23:321-9. 2006..Studies have demonstrated that patients with Barrett's oesophagus have the highest oesophageal acid exposure profile, followed by erosive oesophagitis and non-erosive reflux disease patients, but the exact extent of overlap remains unknown...
- Early heartburn relief with proton pump inhibitors: a systematic review and meta-analysis of clinical trialsKenneth R McQuaid
Department of Medicine, University of California San Fransisco, CA, USA
Clin Gastroenterol Hepatol 3:553-63. 2005Proton pump inhibitors (PPIs) are often taken for short-term treatment of heartburn. We performed a systematic review of the efficacy of PPIs for heartburn relief within the first 1-2 days of therapy.
- Predictors of heartburn resolution and erosive esophagitis in patients with GERDRoy C Orlando
University of North Carolina Division of Gastroenterology and Hepatology, Chapel Hill, NC 27599 7032, USA
Curr Med Res Opin 25:2091-102. 2009..assess gastroesophageal reflux disease (GERD) symptom resolution rates with esomeprazole by erosive esophagitis (EE) status, and the secondary objective was to evaluate potential predictors of the presence of EE and heartburn resolution.
- Social and medical impact, sleep quality and the pharmaceutical costs of heartburn in TaiwanC L Lu
Division of Gastroenterology, Taipei Veterans General Hospital, and School of Medicine, National Yang Ming University, Taipei, Taiwan
Aliment Pharmacol Ther 22:739-47. 2005Little is known about the social and medical burdens of heartburn in Asia.
- Symptom-relieving effect of esomeprazole 40 mg daily in patients with heartburnF Johnsson
Dept of Surgery, Lund University Hospital, Lund, Sweden
Scand J Gastroenterol 38:347-53. 2003To assess symptom relief in patients with heartburn following treatment with esomeprazole 40 mg daily.
- Comparison of the different characteristics of sensed reflux events among different heartburn groupsRon Schey
Section of Gastroenterology, Department of Medicine, The Neuroenteric Clinical Research Group, Southern Arizona VA Health Care, Tucson, AZ, USA
J Clin Gastroenterol 43:699-704. 2009Presently, there are no studies comparing sensed acid reflux event (SARE) characteristics among different heartburn groups...
- Psychometric validation of the Japanese translation of the Quality of Life in Reflux and Dyspepsia questionnaire in patients with heartburnMichio Hongo
Department of Comprehensive Medicine, Tohoku University Hospital, 1 1 Seiryo machi, Aoba, Sendai 980 8574, Japan
J Gastroenterol 42:807-15. 2007The purpose of this study was to document the psychometric characteristics of the Japanese translation of the Quality of Life in Reflux and Dyspepsia (QOLRAD-J) questionnaire in patients with heartburn.
- Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburnEdoardo Savarino
Gastroenterology Unit, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Via Giustiniani, 2, 35121, Padua, Italy
J Gastroenterol 48:473-82. 2013..We aimed to compare these histological abnormalities in healthy volunteers (HVs) and patients with erosive esophagitis (EE), NERD, and functional heartburn (FH).
- Health state utilities in gastroesophageal reflux disease patients with heartburn: a study in Germany and SwedenBernt Kartman
AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
Med Decis Making 24:40-52. 2004..of this study were to assess health state utilities in patients with gastroesophageal reflux disease with heartburn and to analyze if severity and annual frequency of heartburn can predict utilities...
- Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux diseasePeter J Kahrilas
Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Clin Gastroenterol Hepatol 10:612-9. 2012..We evaluated the responsiveness of regurgitation, characterized by the reflux disease questionnaire (RDQ) to potent acid suppression...
- Efficacy of rabeprazole on heartburn symptom resolution in patients with non-erosive and erosive gastro-oesophageal reflux disease: a multicenter study from JapanH Miwa
Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
Aliment Pharmacol Ther 26:69-77. 2007..Few studies have compared the efficacy of proton pump inhibitors in resolving the symptoms of non-erosive reflux disease (NERD) and of erosive gastro-oesophageal reflux disease (GERD) in Japan...
- Nausea, vomiting, and heartburn in pregnancy: a prospective look at risk, treatment, and outcomeChristopher R Naumann
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
J Matern Fetal Neonatal Med 25:1488-93. 2012To examine risk factors, treatment, and outcomes for nausea/vomiting (N/V) and heartburn during pregnancy.
- Pathophysiological characteristics of patients with non-erosive reflux disease differ from those of patients with functional heartburnM Frazzoni
Divisione di Medicina Interna e Gastroenterologia, Ospedale S Agostino, Modena, Italy
Aliment Pharmacol Ther 20:81-8. 2004Patients with endoscopy-negative heartburn can be subdivided into non-erosive reflux disease and functional heartburn on the basis of abnormal and normal, respectively, oesophageal acid exposure...
- Review article: management of mild and severe gastro-oesophageal reflux diseaseG N J Tytgat
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Aliment Pharmacol Ther 17:52-6. 2003..Also poorly understood is the lower yield of complete heartburn relief when the number of associated dyspeptic symptoms is high...
- Heartburn severity does not predict disease severity in patients with erosive esophagitisM Brian Fennerty
Division of Gastroenterology, Oregon Health and Science University, Portland, Oregon, USA
MedGenMed 8:6. 2006For patients with gastroesophageal reflux disease (GERD), it is often assumed by treating physicians that the severity of heartburn correlates with the severity of erosive esophagitis (EE).
- Treatment of heartburn and acid reflux associated with nausea and vomiting during pregnancyRuth Law
Leslie DanFaculty of Pharmacy, University of Toronto, Toronto, Canada
Can Fam Physician 56:143-4. 2010..and vomiting of pregnancy, which is being treated with antiemetics, some of my pregnant patients complain of heartburn and acid reflux...
- Air swallowing can be responsible for non-response of heartburn to high-dose proton pump inhibitorP Zentilin
Department of Internal Medicine, University of Genoa, Viale Benedetto XV, N 6, 16132 Genoa, Italy
Dig Liver Dis 37:454-7. 2005..She continued to complain of heartburn as major symptom and impedance allowed us to clarify that it was not related to acid or non-acid reflux, but to ..
- Patients with functional heartburn are more likely to report retrosternal discomfort during wireless pH monitoringYi Chia Lee
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
Gastrointest Endosc 62:834-41. 2005..Although the wireless Bravo pH system is effective, some patients experience retrosternal sensations possibly caused by esophageal sensitivity that may complicate clinical application...
- Heartburn: cardiac potassium channels involved in parietal cell acid secretionSiegfried Waldegger
Department of Paediatrics, University Hospital Marburg, Deutschhausstrasse 12, 35037, Marburg, Germany
Pflugers Arch 446:143-7. 2003....
- Health-related quality of life improves with treatment-related GERD symptom resolution after adjusting for baseline severityDennis A Revicki
Center for Health Outcomes Research, MEDTAP International, Inc, Bethesda, Maryland, USA
Health Qual Life Outcomes 1:73. 2003..This study evaluated the association between baseline heartburn severity and endpoint HRQL of patients treated for heartburn and the relationship between complete resolution of ..
- Functional heartburn and non-erosive reflux diseaseVincenzo Savarino
Dipartimento di Medicina Interna e Specialita Mediche, Universita degli Studi di Genova, Genova, Italy
Dig Dis 25:172-4. 2007..are a heterogeneous group including various subpopulations with different mechanisms for their main symptom of heartburn: reflux of acidic and non-acidic gastric contents, mucosal hypersensitivity, intraesophageal distension by gas, ..
- Effects of antacid formulation on postprandial oesophageal acidity in patients with a history of episodic heartburnM Robinson
Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Aliment Pharmacol Ther 16:435-43. 2002b>Heartburn self-treatment with antacids is extremely common. If the oesophagus is the primary site of antacid action, chewable antacids might raise the oesophageal pH more effectively than swallowable tablets.
- Increased frequency and enhanced perception of reflux in non-erosive reflux disease patients non-responders to proton pump inhibitorsMentore Ribolsi
Department of Digestive Disease, University Campus Bio Medico, Rome, Italy
Dig Liver Dis 44:549-54. 2012..Non-responder patients, evaluated under treatment, present symptoms which are related to non-acidic, mixed and proximal reflux episodes...
- Heartburn and regurgitation in pregnancy: the effect of fat ingestionValesca Dall'Alba
Post Graduate Program, Sciences in Gastroenterology, School of Medicine and Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
Dig Dis Sci 55:1610-4. 2010..Reflux symptoms are common in pregnancy, but their association with fat ingestion is unclear...
- Effects of a single dose of rabeprazole 20 mg and pantoprazole 40 mg on 24-h intragastric acidity and oesophageal acid exposure: a randomized study in gastro-oesophageal reflux disease patients with a history of nocturnal heartburnP Miner
Oklahoma Foundation for Digestive Research, Oklahoma City, OK, USA
Aliment Pharmacol Ther 31:991-1000. 2010Nocturnal heartburn is common in patients with gastro-oesophageal reflux disease (GERD).
- Heartburn and related factors in general population in Tehran, capital of IranA Safaee
Research Center for Gastroenterology and Hepathology, 7th Floor, Taleghani Hospital, Chamran Highway, Tabnak St, Yaman Ave, Velenjak, Tehran, Iran
East Afr J Public Health 7:196-8. 2010b>Heartburn is a highly prevalent disorder and is one of the most common gastrointestinal (GI) symptoms encountered in clinical practice...
- Heartburn: community perceptionsT D Bolin
The Gut Foundation, Prince of Wales Hospital, Randwick, New South Wales, Australia
J Gastroenterol Hepatol 15:35-9. 2000To determine the prevalence of heartburn in the Australian community, and document factors precipitating it and medications used in treatment.
- Clinical trial: factors associated with resolution of heartburn in patients with reflux oesophagitis--results from the EXPO studyJ Labenz
Medical Department, Ev Jung Stilling Hospital, Siegen, Germany
Aliment Pharmacol Ther 29:959-66. 2009..The ability to predict symptom response to reflux oesophagitis-healing therapy may optimize treatment decisions...
- Cost-effectiveness and cost-utility of long-term management strategies for heartburnRon Goeree
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 1G6, Canada
Value Health 5:312-28. 2002To compare the expected costs and outcomes of seven alternative long-term primary care strategies for the management of patients with moderate-to-severe heartburn over a 1-year period.
- Functional heartburn: what it is and how to treat itRonnie Fass
Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, GI Section 1 111G 1, 3601 South 6th Avenue, Tucson, AZ 85723 0001, USA
Gastrointest Endosc Clin N Am 19:23-33, v. 2009Functional heartburn is considered one of the most common functional esophageal disorders...
- Clinical trial: factors associated with freedom from relapse of heartburn in patients with healed reflux oesophagitis--results from the maintenance phase of the EXPO studyJ Labenz
Medical Department, Ev Jung Stilling Hospital, Siegen, Germany
Aliment Pharmacol Ther 29:1165-71. 2009Ability to predict freedom from heartburn relapse during maintenance therapy for healed reflux oesophagitis may facilitate optimal treatment choices for individual patients.
- Heartburn: another danger in the night?William C Orr
Chest 127:1486-8. 2005
- Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugsC J Hawkey
Institute of Clinical Research Trials Unit, University Hospital, Nottingham, UK
Aliment Pharmacol Ther 25:813-21. 2007The use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal symptoms such as heartburn and acid regurgitation.
- Erosive esophagitis and NERD: Can we really classify patients with heartburn by endoscopic findings?William D Chey
Clin Gastroenterol Hepatol 2:654-5. 2004
- Body mass index, chronic atrophic gastritis and heartburn: a population-based study among 8936 older adults from GermanyL Gao
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Baden Wurttemberg, Germany
Aliment Pharmacol Ther 32:296-302. 2010..It has been suggested that this relationship is as a consequence of an increased gastric acid reflux, which is caused by an enhanced intra-abdominal pressure...
- The effect of life stress on symptoms of heartburnBruce D Naliboff
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, Los Angeles, CA, USA
Psychosom Med 66:426-34. 2004..The present longitudinal study tests the general hypothesis that life stressors can exacerbate symptoms in patients with chronic heartburn.
- Refractory heartburn to proton pump inhibitors: epidemiology, etiology and managementSpiros N Sgouros
Department of Gastroenterology, Athens Naval Hospital, GR 15341 Athens, Greece
Digestion 73:218-27. 2006Patients with refractory heartburn to proton pump inhibitors (PPIs) represent a distinctive group which is difficult to manage...
- Serum lipid levels are positively associated with non-erosive reflux disease, but not with functional heartburnJ Matsuzaki
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Neurogastroenterol Motil 22:965-70, e251. 2010..Although non-erosive reflux disease (NERD) is probably associated with obesity or other metabolic syndrome, there is little direct evidence to support this assertion...
- Modulation of salivation and heartburn in response to the site of acid infusion in the human oesophagusS K Dutta
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
Aliment Pharmacol Ther 32:795-800. 2010..This may depend upon the height of acid wave and magnitude of oesophageal mucosal exposure. Interestingly, the effect of site of acid infusion upon salivary secretion and heartburn has not been examined in any detail.
- Sleep issues in gastroesophageal reflux disease: beyond simple heartburn controlWilliam C Orr
Lynn Health Science Institute, Oklahoma City, Oklahoma, USA
Rev Gastroenterol Disord 3:S22-9. 2003..Nocturnal GER can lead to the development of esophagitis and other extra esophageal complications, such as exacerbation of asthmatic symptoms...
- Comparison of objective outcomes following laparoscopic Nissen fundoplication versus laparoscopic gastric bypass in the morbidly obese with heartburnE J Patterson
Department of Minimally Invasive Surgery, Legacy Health System, 501 North Graham Street, Suite 120, Portland, OR 97227, USA
Surg Endosc 17:1561-5. 2003b>Heartburn and gastroesophageal reflux disease (GERD) affects approximately 25-50% of morbidly obese patients...
- Prevalence of acid reflux in functional dyspepsia and its association with symptom profileJ Tack
Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
Gut 54:1370-6. 2005..The aim of the present study was to study 24 hour pH monitoring in consecutive functional dyspepsia patients...
- Sustained esophageal contraction: a motor correlate of heartburn symptomN Pehlivanov
Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
Am J Physiol Gastrointest Liver Physiol 281:G743-51. 2001b>Heartburn occurs in the presence as well as the absence of acid reflux. We searched for a motor correlate of heartburn...
- Validation of a symptom diary for patients with gastro-oesophageal reflux diseaseM A Puhan
Horten Centre, University of Zurich, Switzerland
Aliment Pharmacol Ther 23:531-41. 2006..We assessed the validity and responsiveness of a symptom diary for patients with gastro-oesophageal reflux disease...
- Does short-term treatment with proton pump inhibitors cause rebound aggravation of symptoms?P G Farup
Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway
J Clin Gastroenterol 33:206-9. 2001..Rebound acid hypersecretion might occur after treatment with proton pump inhibitors. This study looks for a rebound aggravation of symptoms after short-term treatment with lansoprazole...
- An open-label, multicentre study to assess the safety and efficacy of a novel reflux suppressant (Gaviscon Advance) in the treatment of heartburn during pregnancyS W Lindow
University of Hull, Hull, UK
Int J Clin Pract 57:175-9. 2003..study investigated the efficacy and safety of a novel reflux suppressant, Gaviscon Advance, in the treatment of heartburn during pregnancy...
- Characterization of the cerebral cortical representation of heartburn in GERD patientsMark Kern
Medical College of Wisconsin Dysphagia Institute, Division of Gastroenterology and Hepatology, Digestive Disease Center, Biophysics Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Am J Physiol Gastrointest Liver Physiol 286:G174-81. 2004Although symptoms arising from the esophagus such as heartburn and pain can at times become challenging clinical problems, esophageal viscerosensation, especially with regard to chemical stimulation in humans, is incompletely understood...
- The pathogenesis of heartburn in nonerosive reflux disease: a unifying hypothesisWilliam J Barlow
Tulane University Health Sciences Center, Department of Medicine SL 35, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA
Gastroenterology 128:771-8. 2005b>Heartburn is a symptom complex that has traditionally been accepted as an acid-mediated event and a reliable indicator of gastroesophageal reflux disease...
- Proton-pump inhibitor therapy induces acid-related symptoms in healthy volunteers after withdrawal of therapyChristina Reimer
Department of Medical Gastroenterology, Køge University Hospital, Copenhagen University, Copenhagen, Denmark
Gastroenterology 137:80-7, 87.e1. 2009..Rebound acid hypersecretion (RAHS) has been demonstrated after 8 weeks of treatment with a proton-pump inhibitor (PPI). If RAHS induces acid-related symptoms, this might lead to PPI dependency and thus have important implications...
- The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux diseaseEdoardo Savarino
Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, Italy Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Milan, Italy
Dig Liver Dis 43:542-7. 2011Functional heartburn is defined by Rome III criteria as an endoscopy-negative condition with normal oesophageal acid exposure time, negative symptom association to acid reflux and unsatisfactory response to proton pump inhibitors...
- Heartburn in Belgium: prevalence, impact on daily life, and utilization of medical resourcesEdouard Louis
Gastroenterology Department, CHU of Liege, Brussels, Belgium
Eur J Gastroenterol Hepatol 14:279-84. 2002..The specificity of heartburn for the diagnosis of GORD is good...
- Heartburn-dominant, uninvestigated dyspepsia: a comparison of 'PPI-start' and 'H2-RA-start' management strategies in primary care--the CADET-HR StudyD Armstrong
Division of Gastroenterology, McMaster University, Hamilton, Ontario, Canada
Aliment Pharmacol Ther 21:1189-202. 2005There are few data on empiric, stepped therapy for heartburn relief or subsequent relapse in primary care.
- Treatment of patients with persistent heartburn symptoms: a double-blind, randomized trialRonnie Fass
The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723 0001, USA
Clin Gastroenterol Hepatol 4:50-6. 2006..2 therapeutic strategies, increasing the proton pump inhibitor dosage to twice daily versus switching to another proton pump inhibitor, in patients with persistent heartburn while receiving standard-dose proton pump inhibitor therapy.
- Nighttime heartburn is an under-appreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological AssociationReza Shaker
Medical College of Wisconsin Dysphagia Institute, Division of Gastroenterology and Hepatology, Milwaukee, Wisconsin, USA
Am J Gastroenterol 98:1487-93. 2003..as well as adenocarcinoma of the esophagus, a better understanding of the prevalence and impact of nighttime heartburn as a sign of nocturnal acid reflux events can have significant potential management implications...
- Helicobacter pylori infection in patients with erosive esophagitis is associated with rapid heartburn relief and lack of relapse after treatment with pantoprazoleJosé L Calleja
Recordati España, Scientific Research Department, Spain
Dig Dis Sci 50:432-9. 2005..Healing and symptom relief rates for HP infection were compared. We found complete relief of heartburn in 72.3% of the HP-positive versus 58.8% of the HP-negative group (P < 0.05)...
- Endoscopic and histologic findings in Iranian patients with heartburnYousef Bafandeh
Department of Gastroenterology, Tabriz University of Medical Sciences, Tabriz, Iran
Indian J Gastroenterol 24:236-8. 2005b>Heartburn is a common manifestation of gastroesophageal reflux disease. Barrett's esophagus and esophageal adenocarcinoma, known complications of this disease, appear to be less prevalent in Asia than in Western countries...
- Quantitative assessment and characterization of visceral hyperalgesia evoked by esophageal balloon distention and acid perfusion in patients with functional heartburn, nonerosive reflux disease, and erosive esophagitisMin Yang
Department of Gastroenterology, Daping Hospital, Chongqing, China
Clin J Pain 26:326-31. 2010The role of esophageal hypersensitivity in functional heartburn (FH) with negative pH test, negative symptom index, and the proton pump inhibitor (PPI) failure has not been established...
- Recurrent symptoms after fundoplication with a negative pH study--recurrent reflux or functional heartburn?Sarah K Thompson
Discipline of Surgery, University of Adelaide, Adelaide, South Australia, Australia
J Gastrointest Surg 13:54-60. 2009A small cohort of patients present after antireflux surgery complaining of recurrent heartburn. Over two thirds of these patients will have a negative 24-h pH study...
- Heartburn during sleep: a clinical marker of gastro-oesophageal reflux disease in morbidly obese patientsF Fornari
Laboratory of Oesophageal Motility, ENDOPASSO, Passo Fundo RS, Brazil
Neurogastroenterol Motil 21:136-42. 2009..The aim of this study was to assess the prevalence of heartburn during sleep (HDS) and whether this symptom predicts the presence of objective GORD parameters and increased ..
- Functional heartburn patients demonstrate traits of functional bowel disorder but lack a uniform increase of chemoreceptor sensitivity to acidMichael Shapiro
The Neuro Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723 0001, USA
Am J Gastroenterol 101:1084-91. 2006Functional heartburn (FH) patients have a profound impact on the response to anti-reflux therapy of the nonerosive reflux disease (NERD) group as compared to the response of the erosive esophagitis group...
- Review article: the role of acid suppression in patients with non-erosive reflux disease or functional heartburnK R Devault
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Jacksonville, FL 32233, USA
Aliment Pharmacol Ther 23:33-9. 2006When patients with the typical reflux symptoms of heartburn, regurgitation, or both, undergo endoscopy, up to 75% will not have endoscopic oesophagitis or evidence of Barrett's oesophagus...
- Esophageal visceral sensitivity to bile salts in patients with functional heartburn and in healthy control subjectsAli Siddiqui
Oklahoma Foundation for Digestive Research, Oklahoma City, Oklahoma 73104, USA
Dig Dis Sci 50:81-5. 2005..We have demonstrated that gastric contents can cause heartburn when the gastric pH >4. (Aliment Pharm Ther 14:129-134, 2000)...
- Beyond heartburn: a systematic review of the extra-oesophageal spectrum of reflux-induced diseaseA Pali S Hungin
Cetre for Integrated Health Care Research, University of Durham Stockton Campus, Wolfson Research Institute, Stockton on Tees TS176BH, UK
Fam Pract 22:591-603. 2005..GORD is characterized by heartburn and acid regurgitation, but is reported to be associated with a spectrum of extra-oesophageal symptoms.
- Heartburn in primary care: problems below the surfaceGerald Holtmann
Division of Internal Medicine, Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
J Gastroenterol 39:1027-34. 2004b>Heartburn is a common physiological event often associated with an underlying occurrence of gastroesophageal reflux disease (GERD)...
- Determinants of perception of heartburn and regurgitationA J Bredenoord
Department of Gastroenterology, St Antonius Hospital, PO Box 2500, 3430 EM Nieuwegein, and Gastrointestinal Research Centre, University Medical Centre, Utrecht, The Netherlands
Gut 55:313-8. 2006..It is not known why some reflux episodes evoke symptoms and others do not. We investigated the determinants of perception of gastro-oesophageal reflux...
- [Nationwide epidemiological survey regarding heartburn and reflux esophagitis in Japanese]Syuichi Ohara
The Health Administration Center, Tohoku University
Nihon Shokakibyo Gakkai Zasshi 102:1010-24. 2005The details on prevalence of heartburn and reflux esophagitis have not been clarified, since no large-scale survey has been conducted to date...
- Prevalence of heartburn and gastroesophageal reflux disease in the urban Brazilian populationJoaquim Prado P Moraes-Filho
Department of Gastroenterology, Faculty of Medicine, Clinics Hospital, University of Sao Paulo, Brazil
Arq Gastroenterol 42:122-7. 2005The epidemiological aspects of heartburn and gastroesophageal reflux disease have been object of growing interest in the last decade because of its increasing prevalence and the complications of the disease.
- Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter projectRichard F Harvey
Frenchay Hospital, North Bristol NHS Trust, Bristol BS16 1LE
BMJ 328:1417. 2004To investigate the effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux.
- Comparing lansoprazole and omeprazole in onset of heartburn relief: results of a randomized, controlled trial in erosive esophagitis patientsJ E Richter
Department of Gastroenterology, The Cleveland Clinic Foundation, Ohio 44195, USA
Am J Gastroenterol 96:3089-98. 2001..double-blind, multicenter study was conducted to confirm a previous finding that lansoprazole relieves heartburn faster than omeprazole in patients with erosive esophagitis...
- Association of body mass index with heartburn, regurgitation and esophagitis: results of the Progression of Gastroesophageal Reflux Disease studyMarc Nocon
Institute for Social Medicine, Epidemiology, and Health Economics, Charite University Medical Center, Berlin, Germany
J Gastroenterol Hepatol 22:1728-31. 2007..The aim of the present study was to analyze the impact of body mass index (BMI) on the severity and frequency of reflux symptoms and esophagitis in a large cohort of reflux patients...
- Management of heartburn in a large, randomized, community-based study: comparison of four therapeutic strategiesC W Howden
Northwestern University Medical School, Chicago, Illinois, USA
Am J Gastroenterol 96:1704-10. 2001OBJECTIVE: Our objective was to compare four management strategies for heartburn: therapy with an H2-receptor antagonist (ranitidine), therapy with a proton pump inhibitor (lansoprazole), crossover from ranitidine to lansoprazole ("..
- Quality of life in patients with endoscopy-negative heartburn: reliability and sensitivity of disease-specific instrumentsN J Talley
Department of Medicine, The University of Sydney, The Nepean Hospital, Penrith, Australia
Am J Gastroenterol 96:1998-2004. 2001..METHODS: Patients (n = 1143) with heartburn, but no esophagitis included in a randomized clinical trial assessing the effectiveness of active treatment with ..
- Functional heartburn vs. non-erosive reflux disease: similarities and differencesT Hershcovici
Gastroenterology Unit, Hadassah Hebrew University Medical Centre, Jerusalem, Israel
Aliment Pharmacol Ther 27:1103-9. 2008Bowel symptoms have been associated with non-erosive reflux disease (NERD). However, their role in functional heartburn (FH) has not been established.
- Differences in recognition of heartburn symptoms between Japanese patients with gastroesophageal reflux, physicians, nurses, and healthy lay subjectsNoriaki Manabe
Division of Endoscopy and Ultrasonography, Kawasaki Medical School, Kurashiki, Japan
Scand J Gastroenterol 43:398-402. 2008Patients who complain of "heartburn" to their general practitioner tend to use the word to indicate a variety of symptoms...
- Clinical trial: efficacy and safety of dexlansoprazole MR 60 and 90 mg in healed erosive oesophagitis - maintenance of healing and symptom reliefC W Howden
Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Aliment Pharmacol Ther 30:895-907. 2009..Dexlansoprazole MR, a modified-release formulation of dexlansoprazole, an enantiomer of lansoprazole, effectively heals erosive oesophagitis...
- Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in manS Kindt
Department of Pathophysiology, Center for Gastroenterological Research, K U Leuven, Belgium
Neurogastroenterol Motil 21:1032-e82. 2009b>Heartburn is the most typical gastro-oesophageal reflux disease (GERD) symptom. The transient receptor potential vanilloid receptor-1 (TRPV(1)) is a candidate mediator of heartburn...
- Mechanisms of heartburnDaphne Ang
Department of Gastroenterology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
Nat Clin Pract Gastroenterol Hepatol 5:383-92. 2008b>Heartburn is a typical symptom of GERD. The spectrum of diseases associated with GERD includes reflux esophagitis, Barrett's esophagus and nonerosive reflux disease (NERD)...
- Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitisDonald O Castell
Department of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston 29425, USA
Am J Gastroenterol 97:575-83. 2002..This study compared esomeprazole with lansoprazole for the healing of erosive esophagitis and resolution of heartburn.
- Clinical trial: the effects of the proton pump inhibitor dexlansoprazole MR on daytime and nighttime heartburn in patients with non-erosive reflux diseaseR Fass
Section of Gastroenterology, University of Arizona Health Science Center and Southern Arizona VA Health Care System, Tucson, AZ 85723, USA
Aliment Pharmacol Ther 29:1261-72. 2009..The proportion of patients who respond to proton pump inhibitor (PPI) therapy is about 20% lower in those with non-erosive reflux disease (NERD) than in those with erosive oesophagitis...
- Pantoprazole rapidly improves health-related quality of life in patients with heartburn: a prospective, randomized, double blind comparative study with nizatidinePierre Pare
Hôpital St Sacrement, Division of Gastroenterology, 1050, Chemin Ste Foy, Quebec G1S 4L8, Canada
J Clin Gastroenterol 37:132-8. 2003..In the absence of an objective marker such as erosions, assessment of treatment efficacy can be based on symptoms and HRQoL...
- Factor structure of the Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire evaluated in patients with heartburn predominant reflux diseaseKároly R Kulich
AstraZeneca R and D Molndal, Molndal, Sweden
Qual Life Res 12:699-708. 2003..To test whether the original factor structure of the Quality of Life in Reflux and Dyspepsia (QOLRAD) can be replicated in Nordic patients and English speaking patients...
- Sufficient control of heartburn in endoscopy-negative gastro-oesophageal reflux disease trialsO Junghard
Dept of Clinical Science, AstraZeneca R and D Molndal, Sweden
Scand J Gastroenterol 38:1197-9. 2003
- Functional heartburn: the stimulus, the pain, and the brainR Fass
Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson 85723, USA
Gut 51:885-92. 2002Functional heartburn is a common disorder and appears to be composed of several distinct subgroups. Identifying the different subgroups based on clinical history only is not achievable at present...
- Lansoprazole in the treatment of heartburn in patients without erosive oesophagitisJ E Richter
The Cleveland Clinic, Cleveland, OH 44195, USA
Aliment Pharmacol Ther 13:795-804. 1999..This randomized, double-blind, multicentre study compared lansoprazole with placebo for symptomatic relief of patients with non-erosive gastro-oesophageal reflux disease (GERD)...
- Complete resolution of heartburn symptoms and health-related quality of life in patients with gastro-oesophageal reflux diseaseD A Revicki
Center for Health Outcomes Research, MEDTAP International, Bethesda, MD 20814, USA
Aliment Pharmacol Ther 13:1621-30. 1999Medical treatments for gastro-oesophageal reflux disease (GERD) vary in their ability to completely resolve heartburn and other symptoms...
- Esomeprazole resolves chronic heartburn in patients without erosive oesophagitisP O Katz
Department of Gastroenterology, Albert Einstein Medical Center, Philadelphia, PA 19141, USA
Aliment Pharmacol Ther 18:875-82. 2003Patients with chronic heartburn but with no endoscopic evidence of erosive oesophagitis require gastric acid suppression to relieve symptoms.
- Nitrergic Neuro-smooth Muscle Transmission in the GutRaj K Goyal; Fiscal Year: 2013..Gastrointestinal motility disorders result in a variety of diseases that cause difficulty in swallowing, heartburn, dyspepsia, constipation and chronic abdominal pain...
- Gastroesophageal Antireflux MechanismsMICHAEL RAYMOND RUGGIERI; Fiscal Year: 2013..Problems associated with GERD include the minor inconveniences of heartburn to the lethal complications of aspirational pneumonia in infancy and esophageal adenocarcinoma in adulthood...
- Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall IschemiaRavinder K Mittal; Fiscal Year: 2013..manometery we found a unique "sustained esophageal contraction (SEC)" in association with esophageal pain and heartburn in the late 90's...
- Epidemiology and Pathophysiology of Reflux Disease in African AmericansFrank K Friedenberg; Fiscal Year: 2013..applicant): This research will help doctors to understand the frequency and risks for esophageal reflux disease (heartburn) in African Americans. The role of obesity and weight loss in the treatment of reflux will be clarified...
- Esophageal Adenocarcinoma Policy Model: Trends, Risk Factors and ScreeningChin Hur; Fiscal Year: 2013..b>Heartburn, the primary symptom of gastroesophageal reflux disease (GERD), affects 60 million Americans and can lead to ..
- Foregut microbiome in development of esophageal adenocarcinomaZhiheng Pei; Fiscal Year: 2012Project Summary Esophageal adenocarcinoma (EA), the type of cancer linked to heartburn due to gastroesophageal reflux diseases (GERD), has increased six fold in the past 30 years, which can not be explained by the usual environmental or ..
- ESOPHAGEAL CYTOPROTECTION--AGENTS AND MECHANISMSRoy Orlando; Fiscal Year: 2009..Since localization to the ICJs is key to validating our proposed pathogenesis of heartburn and esophagitis, another goal is to confirm, using in vivo PD measurements during salt superfusions, that this ..
- ESOPHAGEAL MOTOR FUNCTION IN HEALTH AND DISEASEREZA NONE SHAKER; Fiscal Year: 2012..It is estimated that 7-10% of US population suffers daily from heartburn the cardinal symptom of GERD which negatively impacts the quality of life, work productivity and health care ..
- ESOPHAGEAL MOTOR FUNCTION IN HEALTH AND DISEASEREZA NONE SHAKER; Fiscal Year: 2013..While mucosal injury in GERD responds adequately to medical therapy, remedying the GERD symptoms such as heartburn and sensation/awareness of the refluxate movement within the esophagus referred to as regurgitation movement ..
- Controlling Esophageal Cancer in the US.: A Colloraborative Modeling ProjectGEORG E LUEBECK; Fiscal Year: 2013..b>Heartburn, the primary symptom of gastroesophageal reflux disease (GERD), affects 60 million Americans and can lead to ..
- Esophageal Mast Cell Nerve InteractionsShaoyong Yu; Fiscal Year: 2013Abnormal esophageal sensations, such as esophageal-related noncardiac chest pain and heartburn, are common complaints. The underlying mechanism of such esophageal nociception remains unclear...
- Foregut microbiome in development of esophageal adenocarcinomaZhiheng Pei; Fiscal Year: 2009DESCRIPTION (provided by applicant): Esophageal adenocarcinoma (EA), the type of cancer linked to heartburn due to gastroesophageal reflux diseases (GERD), has increased six fold in the past 30 years, which cannot be explained by the ..
- SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEMKATHY LEPARD; Fiscal Year: 2001..Diabetic patients often experience a wide range of GI discomforts including heartburn, nausea, vomiting, diarrhea, constipation, fecal incontinence and abdominal pain...
- The Prevalence of Barrett's Esophagus in Patients with *Blair Jobe; Fiscal Year: 2004..The prevalence of GERD-related esophageal injury in patients with isolated extraesophageal symptoms (i.e., no heartburn or regurgitation) is unknown...
- A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUSKenneth Wang; Fiscal Year: 2003..Barrett's esophagus is a pre-malignant condition that is produced by gastroesophageal reflux disease (heartburn)...
- NOVEL ERYTHROMYCIN ANALOGS FOR GI MOTILITY DISORDERSChristopher Carreras; Fiscal Year: 2000..PROPOSED COMMERCIAL APPLICATIONS: The ideal motilide will be a safe and effective treatment for common heartburn. Motilides are anticipated to have applications for the treatment of diabetic gastroparesis, postoperative ileus ..
- The Prevention of Esophageal AdenocarcinomaChin Hur; Fiscal Year: 2009..to the alarming increase in the incidence of esophageal adenocarcinoma in the last two decades, patients with heartburn or reflux symptoms are increasingly undergoing endoscopic evaluation...
- Medical and Surgical Treatment of Esophageal RefluxSamuel Finlayson; Fiscal Year: 2003..Approximately 75 million Americans suffer from "heartburn", the most typical symptom of GERD...
- Barrett's Esophagus: Risk Factors in WomenDouglas Corley; Fiscal Year: 2009..It is estimated that 10% of those with chronic heartburn harbor BE, and approximately 25% of subjects with BE are women...
- Prevention of reflux-induced esophageal adenocarcimona by dietary berriesRobert Martin; Fiscal Year: 2009..BE is caused by chronic heartburn, which affects more than 19 million Americans every year...
- LASER CATHETER FOR TREATMENT OF GASTROESOPHAGEAL REFLUXAshok Gowda; Fiscal Year: 2001..PROPOSED COMMERCIAL APPLICATION: It is estimated that 33% of the adult population experience heartburn at least once a month and approximately 14 million Americans, or 7% of the adult population, suffer from ..
- Surveillance for Hepatocellular Carcinoma among HCV-infected VeteransHashem El Serag; Fiscal Year: 2009..Evaluating the extent and patterns of HCC surveillance is crucial in understanding diffusion (and obstacles) of this practice and in designing interventions to improve the implementation of HCC surveillance. ..
- Gene Expression in Barrett's EsophagusHashem El Serag; Fiscal Year: 2006..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
- ROLE OF PUBORECTALIS MUSCLE IN FECAL CONTINENCERAVINDER MITTAL; Fiscal Year: 2007..unreadable] [unreadable]..
- Comparison of Two Therapies for UES DysphagiaReza Shaker; Fiscal Year: 2004..anteroposterior and lateral diameter of maximum deglutitive UES opening, and b. maximum deglutitive laryngeal anterior and superior excursions. ..
- BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTESEllen Ebert; Fiscal Year: 2002..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
- PHARYNGEAL RECEPTORS AND REFLUX DISEASERAVINDER MITTAL; Fiscal Year: 2001..Effects of atropine on the frequency of TLESR and GER in patients with reflux esophagitis. ..
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMICHAEL L CAMILLERI; Fiscal Year: 2010..These actions may be relevant to develop new treatments for IBS. The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
- Predicting CHD Events in Black and White WomenJean C McSweeney; Fiscal Year: 2010..We also will explore the correspondence between the MAPMISS screen scores and CHD diagnostic test results. ..
- Barrett's Esophagus Ablation with Celocoxib TrialCharles Lightdale; Fiscal Year: 2002..Patients will be accrued during the first study year, and will be followed until the last patient enrolled completes one year of treatment. ..
- Treatment of Fear and Pain in Irritable Bowel SyndromeBruce Naliboff; Fiscal Year: 2006..abstract_text> ..
- MITOCHONDRIAL ROLE IN CASPASE PROCESSING AND ACTIVATIONRoberta Gottlieb; Fiscal Year: 2003..Understanding these fundamental processes in the comparatively simple and easily manipulated system of Jurkat cells and Fas-mediated apoptosis can be readily translated to studies in the heart. ..
- VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMENNeil Binkley; Fiscal Year: 2003..abstract_text> ..
- Cohort Study of Nitrate Exposure, MHG, and HealthCatherine Zeman; Fiscal Year: 2004..of nitrate/nitrite containing waters and the overall health effects as they may reflect on the current maximum contaminant level, MCL of 10 ppm (mg/I) nitrate/nitrogen, a level that was set without consideration of a safety factor ..
- Quantitative Approach to Analysis of Cortical DynamicsHualou Liang; Fiscal Year: 2005..abstract_text> ..
- The Epidemiology of Barrett's Esophagus in ChildrenMark Gilger; Fiscal Year: 2005....
- Anatomic and Mechanical Variables of the EGJ in GERDJohn Pandolfino; Fiscal Year: 2006..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
- Cytochrome P450 in Reperfusion InjuryRoberta Gottlieb; Fiscal Year: 2007..This proposal identifies cytochrome P450 monooxygenases as a previously underestimated factor in myocardial reperfusion injury, and establishes the basis for a novel therapeutic approach [unreadable] [unreadable]..
- Bid-Mediated Cytochrome c Release from MitochondriaRoberta Gottlieb; Fiscal Year: 2007..These studies will elucidate the molecular mechanism by which BH3-only proteins cause the release of cytochrome c from mitochondria. [unreadable] [unreadable]..
- ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBSMichael Camilleri; Fiscal Year: 2007..abstract_text> ..
- ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROMEMichael Camilleri; Fiscal Year: 2008..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
- Use of Quantitative RT-PCR for Staging Esophageal CancerJames Luketich; Fiscal Year: 2009..In addition, we believe that this research will answer some very interesting questions about tumor biology and metastasis in esophageal cancer. ..
- MI SYMPTOMS IN WOMEN: DISPARITIES IN WOMEN OF COLORJean McSweeney; Fiscal Year: 2002..This information will facilitate the development of educational materials tailored to women of color and should lead to earlier diagnosis and treatment. ..