Genomes and Genes
Summary: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
Publications362 found, 100 shown here
- Constipation: evaluation and treatmentSatish S C Rao
Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Gastroenterol Clin North Am 32:659-83. 2003b>Constipation is a common clinical problem that comprises a constellation of symptoms that include excessive straining, hard stools, feeling of incomplete evacuation, use of digital maneuvers, or infrequent defecation...
- Functional bowel disordersGeorge F Longstreth
Kaiser Permanente Medical Care Program, San Diego, California 92120, USA
Gastroenterology 130:1480-91. 2006..Irritable bowel syndrome (IBS), functional bloating, functional constipation, and functional diarrhea are best identified by symptom-based approaches...
- Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled studyMark Pimentel
Cedars Sinai Medical Center, Burns and Allen Research Institute, UCLA Geffen School of Medicine, 8635 W 3rd St, Suite 770, Los Angeles, California 90034, USA
Dig Dis Sci 51:1297-301. 2006..This subanalysis was done on the constipation-predominant IBS subgroup of patients (C-IBS) to test the ability of neomycin to improve constipation and its ..
- Childhood functional gastrointestinal disorders: child/adolescentAndrée Rasquin
Division of Pediatric Gastroenterology and Nutrition, CHU Ste Justine, University of Montreal, Montreal, Quebec, Canada
Gastroenterology 130:1527-37. 2006..dyspepsia, irritable bowel syndrome, abdominal migraine, and functional abdominal pain; and (3) functional constipation and non-retentive fecal incontinence...
- Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipationJeffrey M Johnston
Ironwood Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
Gastroenterology 139:1877-1886.e2. 2010..has shown benefit in a proof-of-concept study for the treatment of patients with irritable bowel syndrome (IBS) with constipation (IBS-C). We assessed the efficacy and safety of linaclotide at a daily dose range of 75-600 μg in IBS-C.
- Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipationA Agrawal
Neurogastroenterology Unit, Translational Medicine GI Sciences, University of Manchester, UK
Aliment Pharmacol Ther 29:104-14. 2009A sensation of abdominal swelling (bloating) and actual increase in girth (distension) are troublesome features of irritable bowel syndrome (IBS), which is more common in patients with constipation, especially those with delayed transit.
- A placebo-controlled trial of prucalopride for severe chronic constipationMichael Camilleri
College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
N Engl J Med 358:2344-54. 2008In this 12-week trial, we aimed to determine the efficacy of prucalopride, a selective, high-affinity 5-hydroxytryptamine4 receptor agonist, in patients with severe chronic constipation.
- Systematic review: the effects of fibre in the management of chronic idiopathic constipationN C Suares
Leeds Gastroenterology Institute, Leeds General Infirmary, Great George Street, Leeds, UK
Aliment Pharmacol Ther 33:895-901. 2011Patients with chronic idiopathic constipation are often told to increase dietary fibre intake. Whether this is of any benefit remains unclear.
- Opioid-induced constipation: challenges and therapeutic opportunitiesMichael Camilleri
Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Gastroenterol 106:835-42; quiz 843. 2011..It is estimated that opiate-induced constipation (OIC) is experienced by ~40% of these patients, and that constipation and other gastrointestinal symptoms may ..
- Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled studyM Ke
Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China
Neurogastroenterol Motil 24:999-e541. 2012The study evaluated efficacy and safety of the 2 mg dose of prucalopride compared to placebo in patients with chronic constipation (CC) from the Asia-Pacific region.
- Clinical practice : diagnosis and treatment of functional constipationMerit M Tabbers
Department of Paediatric Gastroenterology and Nutrition, Emma Children s Hospital Academic Medical Centre, H7 250, PO Box 22700, 1100 DD, Amsterdam, The Netherlands
Eur J Pediatr 170:955-63. 2011Childhood functional constipation has an estimated prevalence of 3% in the Western world and is probably the most common gastrointestinal complaint in children...
- Two randomized trials of linaclotide for chronic constipationAnthony J Lembo
Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
N Engl J Med 365:527-36. 2011Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients with chronic constipation.
- Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markersElsa M Eriksson
Unit for Functional Gastroenterology, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
World J Gastroenterol 14:4889-96. 2008..To elucidate the differences in somatic, psychological and biochemical pattern between the subtypes of irritable bowel syndrome (IBS)...
- Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxativesJ Tack
Division of Gastroenterology, Department of Internal Medicine, University Hospital, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
Gut 58:357-65. 2009To determine the efficacy, impact on quality of life (QOL) and safety of prucalopride, a selective, high-affinity 5-HT(4) receptor agonist, in patients with chronic constipation.
- A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North AmericaG Lindsay McCrea
Department of Physiological Nursing, University of California at San Francisco, San Francisco, California, USA
J Pain Symptom Manage 37:737-45. 2009b>Constipation is a common problem and affects between 2% and 28% of the general population. It is thought to affect more women than men. The severity of constipation is variable and it can be an acute or chronic condition...
- Chronic constipationAnthony Lembo
Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
N Engl J Med 349:1360-8. 2003
- Childhood constipation: is there new light in the tunnel?M A Benninga
Department of Paediatric Gastroenterology and Nutrition, Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
J Pediatr Gastroenterol Nutr 39:448-64. 2004
- Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysisNicole C Suares
Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK
Am J Gastroenterol 106:1582-91; quiz 1581, 1592. 2011Chronic idiopathic constipation (CIC) is a common functional gastrointestinal disorder in the community, yet no previous systematic review and meta-analysis has estimated the global prevalence, or potential risk factors for the condition.
- Systematic review on the management of chronic constipation in North AmericaLawrence J Brandt
Division of Gastroenterology, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY, USA
Am J Gastroenterol 100:S5-S21. 2005
- Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrheaNicholas J Talley
Mayo Foundation, Mayo Medical School, Rochester, Minnesota 55905, USA
Am J Gastroenterol 98:2454-9. 2003..uncertain whether symptom patterns differ in subgroups of IBS arbitrarily defined by primary bowel patterns of constipation (IBS-C) and diarrhea (IBS-D)...
- Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the National Health and Wellness SurveyShawn X Sun
Takeda Pharmaceuticals International, Inc, 1 Takeda Parkway, Deerfield, IL 60015, USA
Dig Dis Sci 56:2688-95. 2011There has been limited research addressing the effects of constipation on work productivity and healthcare resource use.
- Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled studyEdward Michna
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Pain 12:554-62. 2011Methylnaltrexone is effective for opioid-induced constipation (OIC) in advanced illness patients...
- Increased prevalence of constipation in pre-school children is attributable to under-consumption of plant foods: A community-based studyWarren T K Lee
Division of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK
J Paediatr Child Health 44:170-5. 2008To evaluate consumption of foods rich in dietary fibre and its relation to the prevalence of constipation in pre-school children.
- Prevalence of constipation: agreement among several criteria and evaluation of the diagnostic accuracy of qualifying symptoms and self-reported definition in a population-based survey in SpainVicente Garrigues
Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain
Am J Epidemiol 159:520-6. 2004The aims of this study were to estimate the prevalence of chronic constipation and to evaluate the diagnostic accuracy of the symptoms and the self-reported definition of constipation...
- Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of womenLaurent Dukas
Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Am J Gastroenterol 98:1790-6. 2003Because the risk factors for constipation in the general population are poorly defined, we examined the association between age, body mass index, and selected lifestyle and dietary factors with the prevalence of constipation in the Nurses'..
- Health related quality of life in disorders of defecation: the Defecation Disorder ListW P Voskuijl
Department of Paediatric Gastroenterology and Nutrition, Emma Children s Hospital Academic Medical Center, Amsterdam, Netherlands
Arch Dis Child 89:1124-7. 2004b>Constipation and encopresis frequently cause problems with respect to emotional wellbeing, and social and family life. Instruments to measure Health Related Quality of Life (HRQoL) in these disorders are not available.
- A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipationA Wald
Section of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Aliment Pharmacol Ther 28:917-30. 2008While numerous studies report prevalence of constipation, use of laxatives is poorly understood.
- Chronic constipation: an evidence-based reviewLawrence Leung
Department of Family Medicine, Queen s University, Kingston, Ontario, Canada
J Am Board Fam Med 24:436-51. 2011Chronic constipation is a common condition seen in family practice among the elderly and women. There is no consensus regarding its exact definition, and it may be interpreted differently by physicians and patients...
- Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trialFlavia Indrio
Department of Pediatrics, Aldo Moro University of Bari, Bari, Italy
JAMA Pediatr 168:228-33. 2014Infantile colic, gastroesophageal reflux, and constipation are the most common functional gastrointestinal disorders that lead to referral to a pediatrician during the first 6 months of life and are often responsible for hospitalization, ..
- Etiologic factors of chronic constipation: review of the scientific evidenceFelix W Leung
Division of Gastroenterology, Research and Medical Services, Sepulveda Ambulatory Care Center and Nursing Home, Sepulveda, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 91343, USA
Dig Dis Sci 52:313-6. 2007..of drugs, hypothyroidism, sex hormones and colorectal cancer obstruction may play a role in the pathogenesis of constipation. A search of recent literature, however, reveals that there is a paucity of evidence-based publications that ..
- Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disordersMalik Hassan Mehmood
Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, Pakistan
J Med Food 13:1086-96. 2010..The aim of this study was to rationalize the medicinal use of pepper and its principal alkaloid, piperine, in constipation and diarrhea using in vitro and in vivo assays...
- Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: clinical characteristics, outcomes, and incidencesLin Chang
Center for Neurobiology Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Am J Gastroenterol 105:866-75. 2010..The RMP was implemented following cases of ischemic colitis (IC) and complications of constipation (CoC) associated with the use of alosetron...
- Perforated colon volvulus coiling around the uterus in a pregnant woman with a history of severe constipationIchiro Iwamoto
Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
J Obstet Gynaecol Res 33:731-3. 2007A case of intestinal volvulus in both the sigmoid colon and cecum in a pregnant woman suffering from severe constipation is reported herein. The fetus was dead and the mother developed acute shock...
- Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipationSatish S C Rao
Department of Medicine, University of Iowa, Iowa City, Iowa 52242 1009, USA
Clin Gastroenterol Hepatol 7:537-44. 2009..We assessed regional and CTT with the SmartPill (SmartPill Corporation, Buffalo, NY), a new wireless pH and pressure recording capsule, in constipated and healthy subjects and compared this with ROM...
- Reassessment of the role of methane production between irritable bowel syndrome and functional constipationManuele Furnari
Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
J Gastrointestin Liver Dis 21:157-63. 2012..Modifications of intestinal gas due to changes in microbiota may produce different symptoms. Our aim was to assess whether different patterns of hydrogen (H₂) and methane (CH₄) excretion were related to some intestinal disturbances...
- Chronic constipation in the elderlyErnest P Bouras
Department of Medicine, Division of Gastroenterology and Hepatology, E6A, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Gastroenterol Clin North Am 38:463-80. 2009Chronic constipation is a common problem in the elderly, with a variety of causes, including pelvic floor dysfunction, medication effects, and numerous age-specific conditions...
- Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approachKaren Reimer
Mundipharma Research GmbH and Co KG, Limburg Lahn, Germany
Pharmacology 83:10-7. 2009..Despite proven analgesic efficacy, the use of opioids is commonly associated with frequently dose-limiting constipation that seriously impacts on patients' quality of life...
- Pharmacological basis for the use of Fumaria indica in constipation and diarrheaAnwar H Gilani
Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
J Ethnopharmacol 96:585-9. 2005..These data indicate that the presence of cholinergic and CCB constituents in Fi.Cr may explain the respective traditional use of Fumaria indica in constipation and diarrhoea.
- Combined oral prolonged-release oxycodone and naloxone in opioid-induced bowel dysfunction: review of efficacy and safety data in the treatment of patients experiencing chronic painKatri Elina Clemens
University of Bonn, Malteser Hospital Bonn Rhein Sieg, Centre for Palliative Medicine, Department of Science and Research, Von Hompesch Str 1, D 53123 Bonn, Germany
Expert Opin Pharmacother 11:297-310. 2010..Agents used at present to manage opioid-induced constipation do not address the underlying opioid receptor-mediated cause of bowel dysfunction and are often ineffective...
- Quality of life in patients with irritable bowel syndromeHubert Monnikes
Department of Medicine, Martin Luther Hospital, Academic Teaching Hospital of Charité Universitätsmedizin Berlin, Germany
J Clin Gastroenterol 45:S98-101. 2011..There seems to be no major differences in HRQoL based on IBS subtype (constipation-dominant or diarrhea-dominant)...
- Factors associated with defecation patterns in 0-24-month-old childrenVildan Taylan Tunc
Department of Family Practice, Ankara Numune Research and Education Hospital, Ankara, Turkey
Eur J Pediatr 167:1357-62. 2008..3% of these infants defecated less than once a day...
- Epidemiology of constipation in North America: a systematic reviewPeter D R Higgins
Department of Internal Medicine, University of Michigan Division of Gastroenterology, Ann Arbor, Michigan, USA
Am J Gastroenterol 99:750-9. 2004The aim of this study was to systematically review the published literature regarding prevalence, risk factors, incidence, natural history, and the effect on quality of life of constipation in North America.
- Opioid receptors in the gastrointestinal tractPeter Holzer
Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
Regul Pept 155:11-7. 2009..Together with inhibition of ion and fluid secretion, these effects cause constipation, one of the most frequent and troublesome adverse reactions of opioid analgesic therapy...
- Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal painK A Nyrop
Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, NC 27599 7080, USA
Aliment Pharmacol Ther 26:237-48. 2007..To provide estimates of actual costs to deliver health care to patients with functional bowel disorders, and to assess the cost impact of symptom severity, recency of onset, and satisfaction with treatment...
- Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled studyE M M Quigley
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Aliment Pharmacol Ther 29:315-28. 2009Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL).
- Epidemiology of constipation in children and adults: a systematic reviewSuzanne M Mugie
Division of Pediatric Gastroenterology, Nationwide Children s Hospital, Columbus, OH, United States
Best Pract Res Clin Gastroenterol 25:3-18. 2011We aimed to review the published literature regarding the epidemiology of constipation in the general paediatric and adult population and to assess its geographic, gender and age distribution, and associated factors...
- Prucalopride, a systemic enterokinetic, for the treatment of constipationA V Emmanuel
St Mark s Hospital, Harrow, Middlesex, UK
Aliment Pharmacol Ther 16:1347-56. 2002Laxatives are frequently ineffective in treating constipation. An alternative therapeutic approach is to target serotonin-4 receptors, which are involved in initiating peristalsis.
- Symptom patterns and relative distribution of functional bowel disorders in 1,023 gastroenterology patients in IranDelnaz Roshandel
Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Taleghani Hospital, Parvaneh Street, Velenjak, Tehran, Iran
Int J Colorectal Dis 21:814-25. 2006..There are scanty data on functional bowel disorder (FBD) patterns in Iran. This first-time study tried to provide preliminary data on relative distribution of different types of FBD and their symptom patterns in Iranian patients...
- Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome--results of two randomized, placebo-controlled studiesD A Drossman
University of North Carolina Center for Functional Gl and Mobility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Aliment Pharmacol Ther 29:329-41. 2009Effective treatments for irritable bowel syndrome with constipation (IBS-C) are lacking.
- The Incidence and gastrointestinal infectious risk of functional gastrointestinal disorders in a healthy US adult populationChad K Porter
Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
Am J Gastroenterol 106:130-8. 2011..Within the active duty military population, a group with known high IGE rates, the population-based incidence, risk factors, and attributable burden of care referable to FGD after IGE are poorly defined...
- Epidemiology of childhood constipation: a systematic reviewMaartje M van den Berg
Department of Pediatric Gastroenterology and Nutrition, Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
Am J Gastroenterol 101:2401-9. 2006A systematic review of the published literature was performed to assess the prevalence, incidence, natural history, and comorbid conditions of functional constipation in children.
- Epidemiology of constipation in Europe and Oceania: a systematic reviewGeorge Peppas
Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
BMC Gastroenterol 8:5. 2008We aimed to review the literature regarding the epidemiology of constipation in Europe and Oceania and the associated prevalence/risk factors.
- An epidemiological survey of constipation in canada: definitions, rates, demographics, and predictors of health care seekingP Pare
Department of Medicine, Laval University, Quebec City, Quebec, Canada
Am J Gastroenterol 96:3130-7. 2001OBJECTIVES: The prevalence of functional constipation is highly variable among epidemiological surveys and may relate to the definitions applied...
- Clinical trial: the efficacy of open-label prucalopride treatment in patients with chronic constipation - follow-up of patients from the pivotal studiesM Camilleri
Mayo Clinic, Rochester, MN 55905, USA
Aliment Pharmacol Ther 32:1113-23. 2010Prucalopride is approved in Europe for symptomatic treatment of chronic constipation in women with inadequate relief from laxatives.
- Development and psychometric testing of the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS)Mariette Bengtsson
Division of Gastroenterology and Hepatology, Department of Medicine, Malmo University Hospital, Sweden
BMC Gastroenterol 7:16. 2007..The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS...
- Risk factors for chronic constipation based on a general practice sampleNicholas J Talley
Department of Medicine, University of Sydney, Nepean Hospital, Penrith NSW, Australia
Am J Gastroenterol 98:1107-11. 2003Many factors have been associated with the occurrence of constipation, particularly poor diet and lack of exercise. However, the importance of medications and general medical illnesses in constipation remains more uncertain...
- Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based studySmita L S Halder
Dyspepsia Center, Enteric Neuroscience Program, Division of Gastroenterology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Gastroenterology 133:799-807. 2007..The natural history of FGID is unknown because of a lack of prospective population-based studies and the indistinct nature of the phenotype. We sought to report the natural history of FGID in a US population...
- Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in miceMamoru Kakino
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
Biosci Biotechnol Biochem 74:1550-5. 2010..and genkwanin-5-O-primeveroside), and senna increased the frequency and weight of stools in loperamide-induced constipation model mice. EEA-1 and EEA-2 did not induce diarrhea as a side effect, but senna induced severe diarrhea...
- Quality of life in patients with irritable bowel syndrome seen in referral centers versus primary care: the impact of gender and predominant bowel patternM Simren
Dept of Internal Medicine, Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska University Hospital, Goteborg, Sweden
Scand J Gastroenterol 36:545-52. 2001..This study aimed to explore these relationships...
- Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disordersH J Kim
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Gut 53:829-37. 2004....
- The prevalence of constipation in institutionalized people with intellectual disabilityC J Bohmer
Academic Hospital Vrije Universiteit, Department of Gastroenterology, 1007 MB Amsterdam, The Netherlands
J Intellect Disabil Res 45:212-8. 2001b>Constipation is a common problem in people with intellectual disability (ID). Laxatives are frequently prescribed with disappointing results...
- Socioenvironmental factors associated with constipation in Hong Kong children and Rome III criteriaYuk H Tam
Department of Surgery, Division of Paediatric Surgery and Paediatric Urology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
J Pediatr Gastroenterol Nutr 55:56-61. 2012Data regarding the prevalence of constipation in the general population of Asian children using internationally standardized definitions are scarce...
- What do we know about dietary fiber intake in children and health? The effects of fiber intake on constipation, obesity, and diabetes in childrenSibylle Kranz
Department of Nutrition Science, Purdue University, West Lafayette, IN, USA
Adv Nutr 3:47-53. 2012..This paper summarizes the currently existing evidence on the implications of dietary fiber intake on constipation, obesity, and diabetes in children...
- Opiate-induced constipation related to activation of small intestine opioid μ2-receptorsWency Chen
Department of Internal Medicine, E Da Hospital and I Shou University, Kaohsiung City, Taiwan 82401, China
World J Gastroenterol 18:1391-6. 2012To investigate the role of opioid μ-receptor subtype in opiate-induced constipation (OIC).
- Constipating and spasmolytic effects of Khat (Catha edulis Forsk) in experimental animalsE Makonnen
Department of Pharmacology, Faculty of Medicine, Addis Ababa University
Phytomedicine 7:309-12. 2000..The antispasmodic effect of khat extract was observed to be similar to that of D-amphetamine...
- Pancolonic motor response to subsensory and suprasensory sacral nerve stimulation in patients with slow-transit constipationP G Dinning
Department of Human Physiology, Flinders University, Bedford Park, South Australia
Br J Surg 99:1002-10. 2012Sacral nerve stimulation (SNS) is emerging as a potential treatment for patients with constipation. Although SNS can elicit an increase in colonic propagating sequences (PSs), the optimal stimulus parameters for this response remain ..
- Recent advances in chronic constipationRitu Walia
Department of Pediatric Gastroenterology and Nutrition, The Children s Hospital, Cleveland Clinic, Cleveland, Ohio44195, USA
Curr Opin Pediatr 21:661-6. 2009Chronic constipation remains one of the most frequent complaints in primary and subspecialty pediatric clinics. It is associated with significant emotional and economic burden for both the children and the caregivers...
- Manometric investigation of anorectal function in early and late stage Parkinson's diseaseG Bassotti
Laboratorio di Motilità Intestinale, Sezione di Gastroenterologia ed Epatologia, Via Enrico Dal Pozzo, 06100 Perugia, Italy
J Neurol Neurosurg Psychiatry 68:768-70. 2000Abnormal gastrointestinal function is relatively frequent in Parkinson's disease, and constipation is a disturbing symptom in many patients...
- Autonomic nervous system activity in constipation-predominant irritable bowel syndrome patientsMarcel Mazur
Department of Pathophysiology, Jagiellonian University, Medical College, Cracow, Poland
Med Sci Monit 18:CR493-499. 2012..Autonomic nervous system dysfunction can contribute to development of irritable bowel syndrome symptoms by disturbing visceral sensations...
- A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipationSatish Rao
Section of Gastroenterology Hepatology, Georgia Health Sciences University, Augusta, Georgia, USA
Am J Gastroenterol 107:1714-24; quiz p.1725. 2012Linaclotide is a minimally absorbed guanylate cyclase-C agonist. The objective of this trial was to determine the efficacy and safety of linaclotide in patients with irritable bowel syndrome with constipation (IBS-C).
- Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation modelZi Huan Yang
The School of Life Science, Sun Yat Sen University, Guangzhou, China
PLoS ONE 3:e3348. 2008Symptoms of constipation are extremely common, especially in the elderly...
- Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)Y F Zhao
Department of Health Statistics, Second Military Medical University, Shanghai, China
Aliment Pharmacol Ther 34:1020-9. 2011The epidemiology and effects of functional constipation (FC) on Chinese people remain unclear.
- Long-term safety and effectiveness of lubiprostone, a chloride channel (ClC-2) activator, in patients with chronic idiopathic constipationAnthony J Lembo
Division of Gastroenterology, Harvard Medical School, 330 Brookline Ave, DA 501, Boston, MA, USA
Dig Dis Sci 56:2639-45. 2011Lubiprostone helps relieve constipation in short-term 4-week studies. There are limited data on long-term pharmacological treatment with lubiprostone for chronic idiopathic constipation.
- Clinical and physiological findings, and possible aetiological factors of rectal hyposensitivityM A Gladman
Academic Department of Surgery and Gastrointestinal Physiology Unit, St Bartholomew s and the London School of Medicine and Dentistry, London, UK
Br J Surg 90:860-6. 2003..Rectal hyposensitivity (RH) relates to insensitivity of the rectum on anorectal physiological investigation and appears common in functional bowel disorders. The clinical significance of this physiological abnormality is unclear...
- Breath hydrogen test after a bean meal demonstrates delayed oro-cecal transit time in children with chronic constipationAna Cristina Fontenele Soares
Pediatric Gastroenterology Division and the Medical Imaging Department, Federal University of Sao Paulo, Sao Paulo, Brazil
J Pediatr Gastroenterol Nutr 41:221-4. 2005To evaluate oro-cecal transit time in children with chronic constipation.
- Clinical utility of colonic and anorectal manometry in chronic constipationSatish S C Rao
Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
J Clin Gastroenterol 44:597-609. 2010b>Constipation is one of the most common digestive problems in North America with significant psychosocioeconomic implications...
- Anorectal function and the effect of biofeedback therapy in ambulatory spinal cord disease patients having constipationDong Hoon Yang
Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
Scand J Gastroenterol 45:1281-8. 2010b>Constipation in patients with mild spinal cord disease is not well investigated yet. We aimed to investigate anorectal function and the effect of biofeedback therapy in constipated patients with mild spinal cord diseases.
- Clinical and laboratory findings in 220 children with recurrent abdominal painC F M Gijsbers
Department of Paediatric Gastroenterology, Juliana Children s Hospital Haga Teaching Hospital, The Hague, The Netherlands
Acta Paediatr 100:1028-32. 2011..To investigate the clinical and laboratory findings in children with recurrent abdominal pain (RAP)...
- Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipationCorinna Koebnick
Department of Interventional Studies, German Institute of Human Nutrition, Bergholz Rehbrücke, Germany
Can J Gastroenterol 17:655-9. 2003The aim of the present study was to investigate the effect of a probiotic beverage on gastrointestinal symptoms in patients with chronic constipation.
- Effects of resistance and functional-skills training on habitual activity and constipation among older adults living in long-term care facilities: a randomized controlled trialMarijke J M Chin A Paw
Department of Public and Occupational Health, EMGO Institute VU University Medical Center Van der Boechorststraat 7 1081 BT Amsterdam, The Netherlands
BMC Geriatr 6:9. 2006..in institutionalised older people are scarce, especially regarding effects on habitual physical activity and constipation. This study investigated the effects of different training protocols on habitual physical activity and ..
- A novel mutation in MED12 causes FG syndrome (Opitz-Kaveggia syndrome)P Rump
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Clin Genet 79:183-8. 2011..G958E). This is the first demonstration that other mutations in this gene can also lead to Opitz-Kaveggia syndrome. The clinical phenotype of these three new cases is reviewed in detail and compared with the previous reported cases...
- Quality of life in children with slow transit constipationMelanie C C Clarke
Department of Surgical Research, Royal Children s Hospital, Parkville, Melbourne, Victoria 3052, Australia
J Pediatr Surg 43:320-4. 2008Slow transit constipation (STC) causes intractable symptoms not readily responsive to laxatives, diet, or life-style changes...
- Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipationHubert P J van der Doef
Department of Pediatric Gastroenterology KE 04 133 1, University Medical Center Utrecht, Postbox 85090, 3508 AB Utrecht, The Netherlands
Curr Gastroenterol Rep 13:265-70. 2011Meconium ileus at birth, distal intestinal obstruction syndrome (DIOS), and constipation are an interrelated group of intestinal obstruction syndromes with a variable severity of obstruction that occurs in cystic fibrosis patients...
- The nursing management of diarrhoea and constipation before and after the implementation of a bowel management protocolS McKenna
Intensive Care Unit, St Vincent's Hospital, Sydney, NSW
Aust Crit Care 14:10-6. 2001Intensive care unit (ICU) patients frequently suffer problems associated with both diarrhoea and constipation. Strategies to optimise the management of these conditions need to focus on improving the communication between staff and ..
- Chronic constipation in the elderlyJuan F Gallegos-Orozco
Division of Gastroenterology, Mayo Clinic in Arizona, Scottsdale, 85259, USA
Am J Gastroenterol 107:18-25; quiz 26. 2012b>Constipation is one of the most frequent gastrointestinal disorders encountered in clinical practice in Western societies. Its prevalence increases with age and is more frequently reported in female patients...
- Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome: a randomized, placebo-controlled and dose-finding studyS Fukudo
Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Neurogastroenterol Motil 23:544-e205. 2011..The aim of this work was to perform a dose-finding study for lubiprostone for the treatment of constipation with or without irritable bowel syndrome (IBS) in Japan.
- Use of health care resources and cost of care for adults with constipationGurkirpal Singh
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA
Clin Gastroenterol Hepatol 5:1053-8. 2007b>Constipation is a multisymptom disorder that frequently compromises quality of life and leads patients to seek medical advice...
- Efficacy of an herbal dietary supplement (Smooth Move) in the management of constipation in nursing home residents: A randomized, double-blind, placebo-controlled studySam Bub
Cedarbrook Nursing Home, Allentown, PA, USA
J Am Med Dir Assoc 7:556-61. 2006To investigate the efficacy and cost effectiveness of an herbal tea, Smooth Move, in nursing home residents with chronic constipation.
- Generalized transit delay on wireless motility capsule testing in patients with clinical suspicion of gastroparesis, small intestinal dysmotility, or slow transit constipationBraden Kuo
Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
Dig Dis Sci 56:2928-38. 2011The prevalence of generalized transit delay and relation to symptoms in suspected gastroparesis, intestinal dysmotility, or slow transit constipation are unknown.
- Sacral nerve stimulation for intractable constipationMichael A Kamm
University Department of Medicine, St Vincent s Hospital, Victoria Parade, Fitzroy, Melbourne 3065, Australia
Gut 59:333-40. 2010Traditional surgical procedures for intractable idiopathic constipation are associated with a variable outcome and substantial morbidity...
- Presence of cholinergic and calcium channel blocking activities explains the traditional use of Hibiscus rosasinensis in constipation and diarrhoeaAnwar H Gilani
Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
J Ethnopharmacol 102:289-94. 2005..extract contains spasmogenic and spasmolytic constituents mediating their effect through cholinergic receptors activation and blockade of Ca(2+) influx, respectively, which may explain its traditional use in constipation and diarrhoea.
- Effect of alosetron on bowel urgency and global symptoms in women with severe, diarrhea-predominant irritable bowel syndrome: analysis of two controlled trialsAnthony J Lembo
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Clin Gastroenterol Hepatol 2:675-82. 2004..The aim of this study was to assess the effect of alosetron on bowel urgency and irritable bowel syndrome (IBS) global improvement in diarrhea-predominant IBS (D-IBS)...
- Prescriptions of Chinese herbal medicine for constipation under the national health insurance in TaiwanMaw Shiou Jong
Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R O C
J Chin Med Assoc 73:375-83. 2010b>Constipation is a common gastrointestinal problem worldwide...
- Constipation in children: an epidemiological study in Sri Lanka using Rome III criteriaShaman Rajindrajith
Department of Paediatrics, Faculty of Medicine, University of Kelaniya, Talagolla Road, Ragama 11010, Sri Lanka
Arch Dis Child 97:43-5. 2012b>Constipation is a common paediatric problem, but its prevalence in Asia is unknown...
- Randomised clinical trial: The ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation--a double-blind studyM Simren
Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Aliment Pharmacol Ther 34:41-50. 2011One half of patients with constipation are not satisfied with available therapies, hence there is a need for more effective and well-tolerated drugs.
- Effects of herbal medicine Dai-Kenchu-to on anorectal function in children with severe constipationN Iwai
Division of Surgery, Children s Research Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan
Eur J Pediatr Surg 17:115-8. 2007We administered the herbal medicine Dai-Kenchu-To (DKT) to children with severe chronic constipation or with severe constipation after surgery for anorectal malformations...
- Constipation and diarrhoea - common adverse drug reactions? A cross sectional study in the general populationGunvor S Fosnes
Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway
BMC Clin Pharmacol 11:2. 2011b>Constipation and diarrhoea are common complaints and often reported as adverse drug reactions. This study aimed at finding associations between drugs and constipation and diarrhoea in a general population.
- Constipation: a potential cause of pelvic floor damage?C Amselem
Pelvic Floor Institute, Barcelona, Spain
Neurogastroenterol Motil 22:150-3, e48. 2010Pelvic floor damage is a major clinical problem usually attributed to obstetric injury. We speculated that constipation may also be an aetiological and preventable factor resulting from repeated stress on the perineum over many years, and ..
- Functional magnetic stimulation in constipation associated with Parkinson's diseaseCheng Ming Chiu
Department of Physical Medicine and Rehabilitation, Far Eastern Memorial Hospital, Taipei, Taiwan, ROC
J Rehabil Med 41:1085-9. 2009....
- Small cell ovarian carcinoma: a rare, aggressive tumor masquerading as constipation in a teenager with a fatal outcomeJesse Barondeau
Department of Pediatrics, Madigan Army Medical Center, Tacoma, WA, USA
J Pediatr Hematol Oncol 32:e139-41. 2010A 16-year-old female presented with symptoms consistent with constipation with no constitutional symptoms. Multiple different laxatives were attempted over 4 months and were unsuccessful...
- Rectal hyposensitivity: prevalence and clinical impact in patients with intractable constipation and fecal incontinenceMarc A Gladman
Academic Department of Surgery and Gastrointestinal Physiology Unit, Barts and The London, Queen Mary s School of Medicine and Dentistry, United Kingdom
Dis Colon Rectum 46:238-46. 2003..The purpose of this study was to determine the prevalence of rectal hyposensitivity and whether the finding of such an abnormality was associated with any clinical impact...
- ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSISJohn R Grider; Fiscal Year: 2013..Disorders of any of these components result in abnormal motility patterns that cause diarrhea or constipation and associated disturbances in absorption of nutrients and water from the gut...
- Effects of spinal cord injury on vagal afferents from the rat bladder and colon.April N Herrity; Fiscal Year: 2013..Patients develop a neurogenic bowel that includes constipation, fecal impaction and incontinence, and increased pain from abdominal distention 66;68;60...
- Iyengar yoga for adolescents and young adults with irritable bowel syndromeSubhadra Evans; Fiscal Year: 2013..Symptoms include discomfort in the abdomen, along with diarrhea and/or constipation and other gastroenterological symptoms, which can significantly impact quality of life and daily functioning of ..
- Novel Phosphate Binder: Effects on Hyperphosphatemia, Vascular Calcification & BoDEANNA J contact NELSON; Fiscal Year: 2010..to a host of problems, including side effects that run the gamut of poor taste, halitosis, gastric bloating, constipation, the number of pills, and cost...
- Modulation of Colonic Epithelial Permeability by Sex HormonesMuriel Larauche; Fiscal Year: 2013..sex differences in the alterations of colonic mucosal neuroimmune functions in relation with abdominal pain and constipation symptoms in IBS patients has not been investigated...
- Epigenetic regulation of stem cell senescence in agingDAVID TOCHUKWU ASUZU; Fiscal Year: 2011..Age-related changes in the GI tract include increased gastroesophageal reflux, irritable bowel syndrome, constipation and fecal incontinence, as well as more subtle dysfunctions such as inability to consume large volumes of food...
- Improving pain and function in hip fractureR Sean Morrison; Fiscal Year: 2013..g., constipation, delirium, sedation, nausea, respiratory depression) and studies suggest that older adults receive ..
- Stem cells for novel gene delivery of nitric oxide in the gutHiroshi Mashimo; Fiscal Year: 2013..of gastrointestinal motility disorders including achalasia, diabetic gastroparesis, pyloric stenosis, chronic constipation, and Hirschsprung's Disease...
- Bile Acids, Genetic Control and Colonic Function in Irritable Bowel SyndromeMICHAEL L CAMILLERI; Fiscal Year: 2013..is reported in 20-75% of patients with chronic diarrhea;BA deficiency is reported in rare cases of childhood constipation. We have previously used microarray and confirmatory qRT-PCR to quantify the expression in colorectal mucosa of ..
- Nitrergic Neuro-smooth Muscle Transmission in the GutRaj K Goyal; Fiscal Year: 2013..been shown to cause diseases causing difficulty in swallowing, gastric stasis, dyspepsia, intestinal stasis and constipation. Defective NO neurotransmission is also implicated in diabetic gastroparesis and functional disorders of the ..
- Ednrb Regulation of Gastrointestinal MotilityKENT CHARLES WILLIAMS; Fiscal Year: 2013..and for other patient populations that suffer from gastroesophageal reflux, irritable bowel syndrome, and constipation. Three specific aims are proposed: Aim 1 will compare the structure and function of the ENS in the small ..
- Regulation of gastrointestinal neuromuscular function by NIBP/NFkB signalingWenhui Hu; Fiscal Year: 2013..associated with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), gastroparesis and chronic constipation/diarrhea...
- PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROMEWilliam E Whitehead; Fiscal Year: 2012..than 50 physiological and psychological variables in 267 IBS patients and identified 4 independent clusters: constipation- predominant (IBS-C), diarrhea-predominant (IBS-D), pain-hypersensitive (IBS-Pn), and psychologically ..
- Opioid tolerance and bowel dysfunctionWilliam L Dewey; Fiscal Year: 2013..in man is limited by side-effects that include analgesic tolerance and opioid-induced bowel dysfunction, with constipation being the most common and debilitating symptom...
- Mechanisms of Altered Gastrointestinal DysfunctionQiQi Zhou; Fiscal Year: 2013..with irritable bowel syndrome (IBS) suffer from chronic abdominal pain and associated GI symptoms - diarrhea, constipation, bloating &urgency...
- ET3-EDNRB Signaling in Enterocolitis Associated with Colonic AganglionosisPHILIP KENT FRYKMAN; Fiscal Year: 2013..g., severe constipation, diarrhea, intestinal inflammation) that predispose to sepsis, and can be life-threatening...
- Impact of Family History of Colon Cancer on Adenomas in 40-49 Year OldsPhilip S Schoenfeld; Fiscal Year: 2012..e., constipation or diarrhea) as their indication for colonoscopy;(B) Identify risk factors associated with advanced adenomas or ..
- Are Autism Spectrum Disorders Associated with Leaky-Gut at an Early Critiacal PerGeert W Schmid-Schoenbein; Fiscal Year: 2013..g., diarrhea, reflux, constipation), 3) diet (breast-milk vs...
- TMS in the Management of Postoperative PainJeffrey J Borckardt; Fiscal Year: 2010..use including respiratory depression, nausea and vomiting, cough suppression, mental clouding, sedation and constipation, and many of these side-effects are particularly problematic in gastric-bypass surgery patients who tend to ..
- Enteric nervous system deficits in Hirschsprung ganglionic bowelMELISSA MUSSER; Fiscal Year: 2013..disorders are a substantial clinical burden with more than 25% of pediatric GI referrals arising from chronic constipation and 63 million people in the US alone suffering from chronic constipation...
- Symptom management for irritable bowel syndrome constipation (IBS-C)Joyce K Anastasi; Fiscal Year: 2013..183 adults, diagnosed with IBS-Constipation (IBS-C) based on the ROME III criteria, will be randomized to one of three conditions: 1) Protocol-oriented Acu/..
- The influence of diabetes on M2 muscarinic receptor contractile functionKIRK JIHYON PAK; Fiscal Year: 2012..with diabetes commonly display aberrant urogenital (voiding dysfunction) and gastrointestinal (Gl) function (constipation and diarrhea), which may be caused, in part, by autonomic neuropathic changes and altered smooth muscle ..
- Engineered Opioid Receptors as Therapeutic Agents for Pain ControlPing Yee Law; Fiscal Year: 2012..Unfortunately, their uses have been associated with many troublesome side effects such as nausea, constipation, respiratory depression, sedation, pruritus, tolerance and dependence development...
- A NURSING STUDY OF GUT FUNCTION IN MENSTRUATING WOMENMargaret McLean Heitkemper; Fiscal Year: 2013..loading), in three groups: moderate to severe diarrhea-predominant IBS versus women with moderate to severe constipation-predominant IBS versus control women;3) test the relationship between vagal tone and rectal hypersensitivity in ..
- Crystallization and structure determination of the mu-opioid receptorRoger K Sunahara; Fiscal Year: 2012..have various adverse and sometimes fatal side-effects including nausea, respiratory depression, addiction, and constipation. A major impediment to the development of drugs that can achieve anti-nociception without the concomitant side ..
- Novel Treatment Strategies for Constipation and Role of Brain-Gut axisSATISH SC RAO; Fiscal Year: 2011DESCRIPTION (provided by applicant): Constipation affects up to 20% of the US population, mainly women and the elderly. Affected individuals experience impaired quality of life and most are dissatisfied with current therapy...
- AEROSOL FUROSEMIDE FOR DYSPNEA RELIEF: LABORATORY AND CLINICAL STUDIESRobert B Banzett; Fiscal Year: 2013..Opiates carry many disadvantages including depression of respiration, confusion, nausea and constipation. Inhaled furosemide aerosol has shown promise in relieving dyspnea with none of these side effects...
- Formation of the Enteric Nervous SystemChen Ming Fan; Fiscal Year: 2013..Deficiency of enteric neurons causes abdominal distention and constipation, a condition of patients suffering from the Hirschsprung's disease...
- Treatment of SLE with ajulemic acid, a non-psychoactive cannabinoid derivativeMeggan Mackay; Fiscal Year: 2013..potential toxicitie including gastrointestinal bleeding and kidney toxicity in the case of NSAIDS, somnolence, constipation and nausea for narcotics and osteoporosis, osteonecrosis, diabetes, cataracts and atherosclerosis for ..
- Functional Relevance of CFTR Trafficking in Vivo to Intestinal DiseaseNadia A Ameen; Fiscal Year: 2013..factors and mechanisms regulating CFTR in the intestine under homeostatic and pathophysiologic conditions and extend insights into CFTR trafficking mechanisms that can be targeted to treat common intestinal diseases such as constipation.
- Analgesics targeting truncated 6transmembrane exon 11 variants of MOR-1 (6TM-E11)Susruta Majumdar; Fiscal Year: 2013..Despite it potent analgesic actions, IBNtxA lacks respiratory depression, significant constipation, physical dependence or reward...
- Intestinal Epithelia Ammonium TransportRoger T Worrell; Fiscal Year: 2012..tract are characterized by the dysregulation of ion and fluid transport resulting in diarrhea or constipation. Over the past fifty years, a plethora of studies have focused on possible mechanisms and treatments for these ..
- Development of NMUR2 Antagonists as Novel AnalgesicsNEIL CUTSHALL; Fiscal Year: 2013..However, these drugs produce severe and unwanted side effects, such as respiratory depression, nausea, constipation and tolerance development (Berde et al, 2008);in addition, they are highly addictive (Koob et al, 1998)...
- Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a FoGregory Scherrer; Fiscal Year: 2011..e. paradoxical hyperalgesia, drug abuse, vomiting, constipation, respiratory depression, etc) and have limited efficacy for the treatment of certain types of chronic pain (i.e...
- Mu opioid agonists with reduced side effects for the treatment of painChad E Groer; Fiscal Year: 2011..receptor (MOR);however, this receptor also mediates unwanted opioid side-effects such as tolerance, dependence, constipation and overdose...
- Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a FoGregory Scherrer; Fiscal Year: 2013..e. paradoxical hyperalgesia, drug abuse, vomiting, constipation, respiratory depression, etc) and have limited efficacy for the treatment of certain types of chronic pain (i...
- Assay for GI Drug DiscoveryLID WONG; Fiscal Year: 2012..are the two predominant drug discovery gastrointestinal (GI) target sites for the treatments of diarrhea, constipation and gastric reflux...
- Obstruction-initiated mechanotranscription in colonic smooth muscle cellsXuan Zheng Shi; Fiscal Year: 2012..hypertrophy), and are responsible for symptoms such as abdominal bloating, vomiting, abdominal cramps, and constipation, and may lead to intestinal failure...
- DEVELOPMENT OF RECEPTOR-SPECIFIC OPIOID PEPTIDE ANALOGSPeter W Schiller; Fiscal Year: 2013..Their propensities to produce analgesic tolerance, physical dependence, constipation and respiratory depression will be examined...
- The Human Microbiome in Pediatric Abdominal Pain and Intestinal InflammationJames Versalovic; Fiscal Year: 2012..In addition to the detailed clinical assessment of healthy children and children with irritable bowel syndrome, constipation, and inflammatory bowel disease (Crohn disease), multiple strategies will be deployed to navigate and ..
- Analgesic Potential of NOP Agonists to Treat Pain in Sickle Cell DiseaseNurulain T Zaveri; Fiscal Year: 2012..pain relief in sickle cell pain, without the liabilities associated with opioid- based therapies, such as constipation, tolerance and dependence...
- Palliative Care Symptom Management in Rural CommunitiesArdith Z Doorenbos; Fiscal Year: 2013..Palliative care aims to provide relief of pain and other patient symptoms, such as fatigue, dyspnea, constipation, anxiety, and depression, in order to improve quality of life...
- Randomized placebo-controlled trial of glutamine for patients with IBSG Nicholas Verne; Fiscal Year: 2012..IBS patients suffer from chronic abdominal pain associated with diarrhea, constipation, and/or bloating (Verne &Cerda, 1997)...
- Conservative Treatment of Fecal Incontinence in the Elderly: Effectiveness TWilliam E Whitehead; Fiscal Year: 2013..behavioral strategies for preventing FI, and use of fiber or nonprescription medication to treat diarrhea or constipation. To minimize drift when the treatment is disseminated to a large group of providers, patient education and ..
- Peripheral activation of Group III mGluR potentiates morphine analgesiaALYSSA LANE BAKER; Fiscal Year: 2013..Major issues accompany opiate use including respiratory depression, tolerance, constipation, insomnia, and nausea...
- Zebrafish Based Model for Gastrointenstinal PhysiologyADAM J RICH; Fiscal Year: 2010..to help identify novel drug targets for the effective treatment of gastrointestinal motility disorders such as constipation, gastroparesis, and bloating...
- Mechanism of Diabetic Enteric NeuropathySHANTHI K SRINIVASAN; Fiscal Year: 2013..One major complication of DM is neuropathies. Constipation is a key consequence of enteric neuropathy and is significantly more common in DM patients with a prevalence of ..
- Computer Assisted Symptom Management for Patients Receiving Radiation TherapyErik K Fromme; Fiscal Year: 2010..experience significant symptoms such as pain, nausea, dyspnea, fatigue, insomnia, anxiety, depression, constipation, and anorexia...
- Ligands that target opioid-chemokine and opioid-mGlu5 heteromersPhilip S Portoghese; Fiscal Year: 2013..increase the efficacy of morphine and prevent the establishment of side effects such as tolerance, dependence, constipation, etc., under inflammatory conditions...
- Structural Approaches for Understanding Opioid and ??-Receptor InteractionsRenyu Liu; Fiscal Year: 2013..for perioperative and chronic pain management, but their side effects, which include respiratory depression, constipation, addiction and others, relate to morbidity and mortality in our patients, as well as presenting a significant ..
- Identification of agents to enhance colonic motility in the elderlyMichael A Pack; Fiscal Year: 2012DESCRIPTION (provided by applicant): Constipation is common in the elderly and in many patients it is a significant problem that affects quality of life...
- Mobile e-Health dietary fiber calculator for self-management of IBSLisa A Russell; Fiscal Year: 2012..Several reviews have concluded that soluble fiber may be more effective than insoluble fiber for constipation, and insoluble fiber may worsen some symptoms...
- Relex Pathways Controlling Intestinal MotilityTERENCE KEITH SMITH; Fiscal Year: 2012..The mechanisms underlying colonic storage and slow transit have remained elusive. Slow transit constipation (STC) has been associated with colonic elongation and other changes, including an excess production of nitric ..
- New Strategies to Treat Overactive BladderChangfeng Tai; Fiscal Year: 2013..treatment within 6-12 months due to its moderate efficacy and significant adverse effects such as dry mouth, constipation, headache, and blurred vision...
- Synthesis and Evaluation of Functionally Biased Opioid AnalgesicsLaura M Bohn; Fiscal Year: 2013..However, this receptor is also the means by which these drugs produce unwanted effects such as constipation, dependence and addiction...
- Pharmacological Studies of NOP ReceptorsMei Chuan Ko; Fiscal Year: 2013..used opioids for the treatment of moderate to severe pain in the clinic, the side effects of mu opioids such as constipation, respiratory depression, pruritus, abuse liability, and physical dependence limit their value as a medication...
- Peripheral FAAH as a target for novel analgesicsMiguel Garcia-Guzman; Fiscal Year: 2013..Clinically used analgesics cause a series of common side effects that include gastric irritation, constipation and sedation. Previous work in our lab has shown that URB937 produces no gastric irritation after oral dosing...
- Managing Medication-induced Constipation in Cancer: A Clinical TrialSusan C McMillan; Fiscal Year: 2012DESCRIPTION (provided by applicant): Constipation is a very common problem among cancer patients and although it is very amenable to nursing intervention, constipation often goes unrecognized and untreated...
- GUCY2C hormone suppression links obesity with colorectal cancerERIK BLOMAIN; Fiscal Year: 2013..The potential for immediate translation of these results to mitigate colorectal cancer risk in obese patients can be appreciated in the context of the recent regulatory approval of oral GUCY2C ligands to treat constipation.
- An Implantable Pacemaker Optimized for Smooth Muscle StimulationROBERT ARTHUR ROSS; Fiscal Year: 2012DESCRIPTION (provided by applicant): Constipation is a common symptom affecting between 2 percent and 27 percent of the population in Western countries. In the United States, it results in more than 2...
- Implementing best practice in palliative careAmy P Abernethy; Fiscal Year: 2013..One example of low conformance with quality metrics identified in QDACT-PC was related to constipation management;data demonstrate that less than 50% of patients are receiving current best practice interventions to ..
- Agonist-Directed MOR Desensitization in Opioid Analgesic ToleranceLaura M Bohn; Fiscal Year: 2010..Mice that lack ?arrestin2 also display significantly reduced morphine-associated side effects, such as constipation and respiratory suppression...
- SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEMKATHY LEPARD; Fiscal Year: 2001..patients often experience a wide range of GI discomforts including heartburn, nausea, vomiting, diarrhea, constipation, fecal incontinence and abdominal pain...
- Endogenous Hormones and Risk of EndometriosisStacey Missmer; Fiscal Year: 2009..Establishment of follow-up among our younger cohort will provide resources for the first prospective study of endometriosis among adolescents. ..
- NC/OFQ analogs as ORL1 agonists to promote gut motilityMARK FINDEIS; Fiscal Year: 2005..ileus (POI) with further utility for the treatment of other Gl motilityrelated disorders, particularly severe constipation. POI is a condition characterized by a lack of bowel motility, abdominal pain, and nausea...
- mu Opioid Receptor Function in the Enteric Nervous SystemCatia Sternini; Fiscal Year: 2007..the effects of opiates, potent drugs used for pain control, including analgesia, opioid bowel syndrome (constipation and abdominal pain), and tolerance...
- MALE UROGENITAL FUNCTION AND CHRONIC SPINAL CORD INJURYCharles Hubscher; Fiscal Year: 2009..In many patients, conscious control of defecation is also lost resulting in fecal incontinence and chronic constipation. Since normal ejaculation, micturition, and defecation require sequential contraction of perineal muscles that ..
- A prospective study of diet and endometriosisStacey Missmer; Fiscal Year: 2006..These analyses will be the first to evaluate the relation between these dietary factors and this important and understudied cause of morbidity among premenopausal women. [unreadable] [unreadable]..
- DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATIONALAN HOFMANN; Fiscal Year: 2005b>Constipation in children is a common, vexing problem for the patient, his or her parents, and the pediatric gastroenterologist. Most cases have no discernible organic cause...
- Development of the enteric nervous system: Cells & genesMichael Gershon; Fiscal Year: 2006..of developmental disorders of the enteric nervous system including Hirschsprung's disease, slow transit constipation and infantile hypertrophic pyloric stenosis...
- Ret Signaling in Paraneoplastic Peripheral NeuropathyJOSEPHINE FOX; Fiscal Year: 2009..c-RET signaling in neurons, which results in clinical symptoms of chronic thyroid disease, such as slow transit constipation and muscle weakness...
- IDENTIFICATION & ANALYSES OF THE UROFACIAL SYNDROME GENEJin Xiong She; Fiscal Year: 2001..is an autosomal recessive disease characterized by congenital obstructive uropathy due to a neurogenic bladder, constipation and abnormal facial expression. Pedigree analysis has shown that a single gene is responsible for the syndrome...
- The Human Microbiome in Pediatric Abdominal Pain and Intestinal InflammationJames Versalovic; Fiscal Year: 2009..In addition to the detailed clinical assessment of healthy children and children with irritable bowel syndrome, constipation, and inflammatory bowel disease (Crohn disease), multiple strategies will be deployed to navigate and ..
- Acetylcholine in Diabetic Enteric Nervous SystemKATHY LEPARD; Fiscal Year: 2004Diabetics report a greater frequency of constipation, diarrhea, urgency, and fecal incontinence than the general population that may reflect alterations in gastrointestinal (GI) motility due to neuropathy of autonomic nerves...
- CONTRACTILE SIGNAL TRANSDUCTION IN ULCERATIVE COLITISWeibiao Cao; Fiscal Year: 2004..the muscle layer, leading to motor dysfunction, which contributes to key clinical symptoms, including diarrhea, constipation, and crampy abdominal pain...
- ORPHANIN FQ (OFQ) EFFECTS ON RAT COLONIC MOTILITYToku Takahashi; Fiscal Year: 2003..This may have important clinical implications since OFQ or its analogues may be beneficial for the treatment of refractory constipation in humans.