constipation

Summary

Summary: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.

Top Publications

  1. ncbi Constipation: evaluation and treatment
    Satish S C Rao
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Gastroenterol Clin North Am 32:659-83. 2003
  2. ncbi Functional bowel disorders
    George F Longstreth
    Kaiser Permanente Medical Care Program, San Diego, California 92120, USA
    Gastroenterology 130:1480-91. 2006
  3. ncbi Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study
    Mark Pimentel
    Cedars Sinai Medical Center, Burns and Allen Research Institute, UCLA Geffen School of Medicine, 8635 W 3rd St, Suite 770, Los Angeles, California 90034, USA
    Dig Dis Sci 51:1297-301. 2006
  4. ncbi Childhood functional gastrointestinal disorders: child/adolescent
    Andrée Rasquin
    Division of Pediatric Gastroenterology and Nutrition, CHU Ste Justine, University of Montreal, Montreal, Quebec, Canada
    Gastroenterology 130:1527-37. 2006
  5. ncbi Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Gastroenterology 139:1877-1886.e2. 2010
  6. ncbi Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation
    A Agrawal
    Neurogastroenterology Unit, Translational Medicine GI Sciences, University of Manchester, UK
    Aliment Pharmacol Ther 29:104-14. 2009
  7. ncbi A placebo-controlled trial of prucalopride for severe chronic constipation
    Michael Camilleri
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 358:2344-54. 2008
  8. ncbi Systematic review: the effects of fibre in the management of chronic idiopathic constipation
    N C Suares
    Leeds Gastroenterology Institute, Leeds General Infirmary, Great George Street, Leeds, UK
    Aliment Pharmacol Ther 33:895-901. 2011
  9. ncbi Opioid-induced constipation: challenges and therapeutic opportunities
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 106:835-42; quiz 843. 2011
  10. pmc Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled study
    M Ke
    Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China
    Neurogastroenterol Motil 24:999-e541. 2012

Detail Information

Publications362 found, 100 shown here

  1. ncbi Constipation: evaluation and treatment
    Satish S C Rao
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Gastroenterol Clin North Am 32:659-83. 2003
    b>Constipation is a common clinical problem that comprises a constellation of symptoms that include excessive straining, hard stools, feeling of incomplete evacuation, use of digital maneuvers, or infrequent defecation...
  2. ncbi Functional bowel disorders
    George F Longstreth
    Kaiser Permanente Medical Care Program, San Diego, California 92120, USA
    Gastroenterology 130:1480-91. 2006
    ..Irritable bowel syndrome (IBS), functional bloating, functional constipation, and functional diarrhea are best identified by symptom-based approaches...
  3. ncbi Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study
    Mark Pimentel
    Cedars Sinai Medical Center, Burns and Allen Research Institute, UCLA Geffen School of Medicine, 8635 W 3rd St, Suite 770, Los Angeles, California 90034, USA
    Dig Dis Sci 51:1297-301. 2006
    ..This subanalysis was done on the constipation-predominant IBS subgroup of patients (C-IBS) to test the ability of neomycin to improve constipation and its ..
  4. ncbi Childhood functional gastrointestinal disorders: child/adolescent
    Andrée Rasquin
    Division of Pediatric Gastroenterology and Nutrition, CHU Ste Justine, University of Montreal, Montreal, Quebec, Canada
    Gastroenterology 130:1527-37. 2006
    ..dyspepsia, irritable bowel syndrome, abdominal migraine, and functional abdominal pain; and (3) functional constipation and non-retentive fecal incontinence...
  5. ncbi Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Gastroenterology 139:1877-1886.e2. 2010
    ..has shown benefit in a proof-of-concept study for the treatment of patients with irritable bowel syndrome (IBS) with constipation (IBS-C). We assessed the efficacy and safety of linaclotide at a daily dose range of 75-600 μg in IBS-C.
  6. ncbi Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation
    A Agrawal
    Neurogastroenterology Unit, Translational Medicine GI Sciences, University of Manchester, UK
    Aliment Pharmacol Ther 29:104-14. 2009
    A sensation of abdominal swelling (bloating) and actual increase in girth (distension) are troublesome features of irritable bowel syndrome (IBS), which is more common in patients with constipation, especially those with delayed transit.
  7. ncbi A placebo-controlled trial of prucalopride for severe chronic constipation
    Michael Camilleri
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 358:2344-54. 2008
    In this 12-week trial, we aimed to determine the efficacy of prucalopride, a selective, high-affinity 5-hydroxytryptamine4 receptor agonist, in patients with severe chronic constipation.
  8. ncbi Systematic review: the effects of fibre in the management of chronic idiopathic constipation
    N C Suares
    Leeds Gastroenterology Institute, Leeds General Infirmary, Great George Street, Leeds, UK
    Aliment Pharmacol Ther 33:895-901. 2011
    Patients with chronic idiopathic constipation are often told to increase dietary fibre intake. Whether this is of any benefit remains unclear.
  9. ncbi Opioid-induced constipation: challenges and therapeutic opportunities
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 106:835-42; quiz 843. 2011
    ..It is estimated that opiate-induced constipation (OIC) is experienced by ~40% of these patients, and that constipation and other gastrointestinal symptoms may ..
  10. pmc Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled study
    M Ke
    Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China
    Neurogastroenterol Motil 24:999-e541. 2012
    The study evaluated efficacy and safety of the 2 mg dose of prucalopride compared to placebo in patients with chronic constipation (CC) from the Asia-Pacific region.
  11. ncbi Clinical practice : diagnosis and treatment of functional constipation
    Merit M Tabbers
    Department of Paediatric Gastroenterology and Nutrition, Emma Children s Hospital Academic Medical Centre, H7 250, PO Box 22700, 1100 DD, Amsterdam, The Netherlands
    Eur J Pediatr 170:955-63. 2011
    Childhood functional constipation has an estimated prevalence of 3% in the Western world and is probably the most common gastrointestinal complaint in children...
  12. ncbi Two randomized trials of linaclotide for chronic constipation
    Anthony J Lembo
    Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
    N Engl J Med 365:527-36. 2011
    Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients with chronic constipation.
  13. pmc Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers
    Elsa M Eriksson
    Unit for Functional Gastroenterology, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    World J Gastroenterol 14:4889-96. 2008
    ..To elucidate the differences in somatic, psychological and biochemical pattern between the subtypes of irritable bowel syndrome (IBS)...
  14. ncbi Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives
    J Tack
    Division of Gastroenterology, Department of Internal Medicine, University Hospital, Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Gut 58:357-65. 2009
    To determine the efficacy, impact on quality of life (QOL) and safety of prucalopride, a selective, high-affinity 5-HT(4) receptor agonist, in patients with chronic constipation.
  15. ncbi A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North America
    G Lindsay McCrea
    Department of Physiological Nursing, University of California at San Francisco, San Francisco, California, USA
    J Pain Symptom Manage 37:737-45. 2009
    b>Constipation is a common problem and affects between 2% and 28% of the general population. It is thought to affect more women than men. The severity of constipation is variable and it can be an acute or chronic condition...
  16. ncbi Chronic constipation
    Anthony Lembo
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    N Engl J Med 349:1360-8. 2003
  17. ncbi Childhood constipation: is there new light in the tunnel?
    M A Benninga
    Department of Paediatric Gastroenterology and Nutrition, Emma Children s Hospital, Academic Medical Centre, Amsterdam, The Netherlands
    J Pediatr Gastroenterol Nutr 39:448-64. 2004
  18. ncbi Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis
    Nicole C Suares
    Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK
    Am J Gastroenterol 106:1582-91; quiz 1581, 1592. 2011
    Chronic idiopathic constipation (CIC) is a common functional gastrointestinal disorder in the community, yet no previous systematic review and meta-analysis has estimated the global prevalence, or potential risk factors for the condition.
  19. ncbi Systematic review on the management of chronic constipation in North America
    Lawrence J Brandt
    Division of Gastroenterology, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Gastroenterol 100:S5-S21. 2005
  20. ncbi Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrhea
    Nicholas J Talley
    Mayo Foundation, Mayo Medical School, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 98:2454-9. 2003
    ..uncertain whether symptom patterns differ in subgroups of IBS arbitrarily defined by primary bowel patterns of constipation (IBS-C) and diarrhea (IBS-D)...
  21. ncbi Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the National Health and Wellness Survey
    Shawn X Sun
    Takeda Pharmaceuticals International, Inc, 1 Takeda Parkway, Deerfield, IL 60015, USA
    Dig Dis Sci 56:2688-95. 2011
    There has been limited research addressing the effects of constipation on work productivity and healthcare resource use.
  22. ncbi Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study
    Edward Michna
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Pain 12:554-62. 2011
    Methylnaltrexone is effective for opioid-induced constipation (OIC) in advanced illness patients...
  23. ncbi Increased prevalence of constipation in pre-school children is attributable to under-consumption of plant foods: A community-based study
    Warren T K Lee
    Division of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK
    J Paediatr Child Health 44:170-5. 2008
    To evaluate consumption of foods rich in dietary fibre and its relation to the prevalence of constipation in pre-school children.
  24. ncbi Prevalence of constipation: agreement among several criteria and evaluation of the diagnostic accuracy of qualifying symptoms and self-reported definition in a population-based survey in Spain
    Vicente Garrigues
    Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain
    Am J Epidemiol 159:520-6. 2004
    The aims of this study were to estimate the prevalence of chronic constipation and to evaluate the diagnostic accuracy of the symptoms and the self-reported definition of constipation...
  25. ncbi Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women
    Laurent Dukas
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 98:1790-6. 2003
    Because the risk factors for constipation in the general population are poorly defined, we examined the association between age, body mass index, and selected lifestyle and dietary factors with the prevalence of constipation in the Nurses'..
  26. pmc Health related quality of life in disorders of defecation: the Defecation Disorder List
    W P Voskuijl
    Department of Paediatric Gastroenterology and Nutrition, Emma Children s Hospital Academic Medical Center, Amsterdam, Netherlands
    Arch Dis Child 89:1124-7. 2004
    b>Constipation and encopresis frequently cause problems with respect to emotional wellbeing, and social and family life. Instruments to measure Health Related Quality of Life (HRQoL) in these disorders are not available.
  27. ncbi A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation
    A Wald
    Section of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Aliment Pharmacol Ther 28:917-30. 2008
    While numerous studies report prevalence of constipation, use of laxatives is poorly understood.
  28. ncbi Chronic constipation: an evidence-based review
    Lawrence Leung
    Department of Family Medicine, Queen s University, Kingston, Ontario, Canada
    J Am Board Fam Med 24:436-51. 2011
    Chronic constipation is a common condition seen in family practice among the elderly and women. There is no consensus regarding its exact definition, and it may be interpreted differently by physicians and patients...
  29. ncbi Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial
    Flavia Indrio
    Department of Pediatrics, Aldo Moro University of Bari, Bari, Italy
    JAMA Pediatr 168:228-33. 2014
    Infantile colic, gastroesophageal reflux, and constipation are the most common functional gastrointestinal disorders that lead to referral to a pediatrician during the first 6 months of life and are often responsible for hospitalization, ..
  30. ncbi Etiologic factors of chronic constipation: review of the scientific evidence
    Felix W Leung
    Division of Gastroenterology, Research and Medical Services, Sepulveda Ambulatory Care Center and Nursing Home, Sepulveda, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, 91343, USA
    Dig Dis Sci 52:313-6. 2007
    ..of drugs, hypothyroidism, sex hormones and colorectal cancer obstruction may play a role in the pathogenesis of constipation. A search of recent literature, however, reveals that there is a paucity of evidence-based publications that ..
  31. ncbi Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders
    Malik Hassan Mehmood
    Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University Medical College, Karachi, Pakistan
    J Med Food 13:1086-96. 2010
    ..The aim of this study was to rationalize the medicinal use of pepper and its principal alkaloid, piperine, in constipation and diarrhea using in vitro and in vivo assays...
  32. ncbi Ischemic colitis and complications of constipation associated with the use of alosetron under a risk management plan: clinical characteristics, outcomes, and incidences
    Lin Chang
    Center for Neurobiology Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Am J Gastroenterol 105:866-75. 2010
    ..The RMP was implemented following cases of ischemic colitis (IC) and complications of constipation (CoC) associated with the use of alosetron...
  33. ncbi Perforated colon volvulus coiling around the uterus in a pregnant woman with a history of severe constipation
    Ichiro Iwamoto
    Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    J Obstet Gynaecol Res 33:731-3. 2007
    A case of intestinal volvulus in both the sigmoid colon and cecum in a pregnant woman suffering from severe constipation is reported herein. The fetus was dead and the mother developed acute shock...
  34. ncbi Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation
    Satish S C Rao
    Department of Medicine, University of Iowa, Iowa City, Iowa 52242 1009, USA
    Clin Gastroenterol Hepatol 7:537-44. 2009
    ..We assessed regional and CTT with the SmartPill (SmartPill Corporation, Buffalo, NY), a new wireless pH and pressure recording capsule, in constipated and healthy subjects and compared this with ROM...
  35. ncbi Reassessment of the role of methane production between irritable bowel syndrome and functional constipation
    Manuele Furnari
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Gastrointestin Liver Dis 21:157-63. 2012
    ..Modifications of intestinal gas due to changes in microbiota may produce different symptoms. Our aim was to assess whether different patterns of hydrogen (H₂) and methane (CH₄) excretion were related to some intestinal disturbances...
  36. ncbi Chronic constipation in the elderly
    Ernest P Bouras
    Department of Medicine, Division of Gastroenterology and Hepatology, E6A, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Gastroenterol Clin North Am 38:463-80. 2009
    Chronic constipation is a common problem in the elderly, with a variety of causes, including pelvic floor dysfunction, medication effects, and numerous age-specific conditions...
  37. ncbi Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approach
    Karen Reimer
    Mundipharma Research GmbH and Co KG, Limburg Lahn, Germany
    Pharmacology 83:10-7. 2009
    ..Despite proven analgesic efficacy, the use of opioids is commonly associated with frequently dose-limiting constipation that seriously impacts on patients' quality of life...
  38. ncbi Pharmacological basis for the use of Fumaria indica in constipation and diarrhea
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 96:585-9. 2005
    ..These data indicate that the presence of cholinergic and CCB constituents in Fi.Cr may explain the respective traditional use of Fumaria indica in constipation and diarrhoea.
  39. ncbi Combined oral prolonged-release oxycodone and naloxone in opioid-induced bowel dysfunction: review of efficacy and safety data in the treatment of patients experiencing chronic pain
    Katri Elina Clemens
    University of Bonn, Malteser Hospital Bonn Rhein Sieg, Centre for Palliative Medicine, Department of Science and Research, Von Hompesch Str 1, D 53123 Bonn, Germany
    Expert Opin Pharmacother 11:297-310. 2010
    ..Agents used at present to manage opioid-induced constipation do not address the underlying opioid receptor-mediated cause of bowel dysfunction and are often ineffective...
  40. ncbi Quality of life in patients with irritable bowel syndrome
    Hubert Monnikes
    Department of Medicine, Martin Luther Hospital, Academic Teaching Hospital of Charité Universitätsmedizin Berlin, Germany
    J Clin Gastroenterol 45:S98-101. 2011
    ..There seems to be no major differences in HRQoL based on IBS subtype (constipation-dominant or diarrhea-dominant)...
  41. ncbi Factors associated with defecation patterns in 0-24-month-old children
    Vildan Taylan Tunc
    Department of Family Practice, Ankara Numune Research and Education Hospital, Ankara, Turkey
    Eur J Pediatr 167:1357-62. 2008
    ..3% of these infants defecated less than once a day...
  42. ncbi Epidemiology of constipation in North America: a systematic review
    Peter D R Higgins
    Department of Internal Medicine, University of Michigan Division of Gastroenterology, Ann Arbor, Michigan, USA
    Am J Gastroenterol 99:750-9. 2004
    The aim of this study was to systematically review the published literature regarding prevalence, risk factors, incidence, natural history, and the effect on quality of life of constipation in North America.
  43. pmc Opioid receptors in the gastrointestinal tract
    Peter Holzer
    Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, A 8010 Graz, Austria
    Regul Pept 155:11-7. 2009
    ..Together with inhibition of ion and fluid secretion, these effects cause constipation, one of the most frequent and troublesome adverse reactions of opioid analgesic therapy...
  44. ncbi Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal pain
    K A Nyrop
    Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, NC 27599 7080, USA
    Aliment Pharmacol Ther 26:237-48. 2007
    ..To provide estimates of actual costs to deliver health care to patients with functional bowel disorders, and to assess the cost impact of symptom severity, recency of onset, and satisfaction with treatment...
  45. ncbi Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study
    E M M Quigley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Aliment Pharmacol Ther 29:315-28. 2009
    Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL).
  46. ncbi Epidemiology of constipation in children and adults: a systematic review
    Suzanne M Mugie
    Division of Pediatric Gastroenterology, Nationwide Children s Hospital, Columbus, OH, United States
    Best Pract Res Clin Gastroenterol 25:3-18. 2011
    We aimed to review the published literature regarding the epidemiology of constipation in the general paediatric and adult population and to assess its geographic, gender and age distribution, and associated factors...
  47. ncbi Prucalopride, a systemic enterokinetic, for the treatment of constipation
    A V Emmanuel
    St Mark s Hospital, Harrow, Middlesex, UK
    Aliment Pharmacol Ther 16:1347-56. 2002
    Laxatives are frequently ineffective in treating constipation. An alternative therapeutic approach is to target serotonin-4 receptors, which are involved in initiating peristalsis.
  48. ncbi Symptom patterns and relative distribution of functional bowel disorders in 1,023 gastroenterology patients in Iran
    Delnaz Roshandel
    Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Taleghani Hospital, Parvaneh Street, Velenjak, Tehran, Iran
    Int J Colorectal Dis 21:814-25. 2006
    ..There are scanty data on functional bowel disorder (FBD) patterns in Iran. This first-time study tried to provide preliminary data on relative distribution of different types of FBD and their symptom patterns in Iranian patients...
  49. ncbi Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome--results of two randomized, placebo-controlled studies
    D A Drossman
    University of North Carolina Center for Functional Gl and Mobility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Aliment Pharmacol Ther 29:329-41. 2009
    Effective treatments for irritable bowel syndrome with constipation (IBS-C) are lacking.
  50. ncbi The Incidence and gastrointestinal infectious risk of functional gastrointestinal disorders in a healthy US adult population
    Chad K Porter
    Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    Am J Gastroenterol 106:130-8. 2011
    ..Within the active duty military population, a group with known high IGE rates, the population-based incidence, risk factors, and attributable burden of care referable to FGD after IGE are poorly defined...
  51. ncbi Epidemiology of childhood constipation: a systematic review
    Maartje M van den Berg
    Department of Pediatric Gastroenterology and Nutrition, Emma Children s Hospital, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 101:2401-9. 2006
    A systematic review of the published literature was performed to assess the prevalence, incidence, natural history, and comorbid conditions of functional constipation in children.
  52. pmc Epidemiology of constipation in Europe and Oceania: a systematic review
    George Peppas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    BMC Gastroenterol 8:5. 2008
    We aimed to review the literature regarding the epidemiology of constipation in Europe and Oceania and the associated prevalence/risk factors.
  53. ncbi An epidemiological survey of constipation in canada: definitions, rates, demographics, and predictors of health care seeking
    P Pare
    Department of Medicine, Laval University, Quebec City, Quebec, Canada
    Am J Gastroenterol 96:3130-7. 2001
    OBJECTIVES: The prevalence of functional constipation is highly variable among epidemiological surveys and may relate to the definitions applied...
  54. ncbi Clinical trial: the efficacy of open-label prucalopride treatment in patients with chronic constipation - follow-up of patients from the pivotal studies
    M Camilleri
    Mayo Clinic, Rochester, MN 55905, USA
    Aliment Pharmacol Ther 32:1113-23. 2010
    Prucalopride is approved in Europe for symptomatic treatment of chronic constipation in women with inadequate relief from laxatives.
  55. pmc Development and psychometric testing of the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS)
    Mariette Bengtsson
    Division of Gastroenterology and Hepatology, Department of Medicine, Malmo University Hospital, Sweden
    BMC Gastroenterol 7:16. 2007
    ..The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS...
  56. ncbi Risk factors for chronic constipation based on a general practice sample
    Nicholas J Talley
    Department of Medicine, University of Sydney, Nepean Hospital, Penrith NSW, Australia
    Am J Gastroenterol 98:1107-11. 2003
    Many factors have been associated with the occurrence of constipation, particularly poor diet and lack of exercise. However, the importance of medications and general medical illnesses in constipation remains more uncertain...
  57. ncbi Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study
    Smita L S Halder
    Dyspepsia Center, Enteric Neuroscience Program, Division of Gastroenterology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 133:799-807. 2007
    ..The natural history of FGID is unknown because of a lack of prospective population-based studies and the indistinct nature of the phenotype. We sought to report the natural history of FGID in a US population...
  58. ncbi Agarwood induced laxative effects via acetylcholine receptors on loperamide-induced constipation in mice
    Mamoru Kakino
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    Biosci Biotechnol Biochem 74:1550-5. 2010
    ..and genkwanin-5-O-primeveroside), and senna increased the frequency and weight of stools in loperamide-induced constipation model mice. EEA-1 and EEA-2 did not induce diarrhea as a side effect, but senna induced severe diarrhea...
  59. ncbi Quality of life in patients with irritable bowel syndrome seen in referral centers versus primary care: the impact of gender and predominant bowel pattern
    M Simren
    Dept of Internal Medicine, Institute of Clinical Neuroscience, Section of Psychiatry, Sahlgrenska University Hospital, Goteborg, Sweden
    Scand J Gastroenterol 36:545-52. 2001
    ..This study aimed to explore these relationships...
  60. pmc Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders
    H J Kim
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gut 53:829-37. 2004
    ....
  61. ncbi The prevalence of constipation in institutionalized people with intellectual disability
    C J Bohmer
    Academic Hospital Vrije Universiteit, Department of Gastroenterology, 1007 MB Amsterdam, The Netherlands
    J Intellect Disabil Res 45:212-8. 2001
    b>Constipation is a common problem in people with intellectual disability (ID). Laxatives are frequently prescribed with disappointing results...
  62. ncbi Socioenvironmental factors associated with constipation in Hong Kong children and Rome III criteria
    Yuk H Tam
    Department of Surgery, Division of Paediatric Surgery and Paediatric Urology, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China
    J Pediatr Gastroenterol Nutr 55:56-61. 2012
    Data regarding the prevalence of constipation in the general population of Asian children using internationally standardized definitions are scarce...
  63. pmc What do we know about dietary fiber intake in children and health? The effects of fiber intake on constipation, obesity, and diabetes in children
    Sibylle Kranz
    Department of Nutrition Science, Purdue University, West Lafayette, IN, USA
    Adv Nutr 3:47-53. 2012
    ..This paper summarizes the currently existing evidence on the implications of dietary fiber intake on constipation, obesity, and diabetes in children...
  64. pmc Opiate-induced constipation related to activation of small intestine opioid μ2-receptors
    Wency Chen
    Department of Internal Medicine, E Da Hospital and I Shou University, Kaohsiung City, Taiwan 82401, China
    World J Gastroenterol 18:1391-6. 2012
    To investigate the role of opioid μ-receptor subtype in opiate-induced constipation (OIC).
  65. ncbi Constipating and spasmolytic effects of Khat (Catha edulis Forsk) in experimental animals
    E Makonnen
    Department of Pharmacology, Faculty of Medicine, Addis Ababa University
    Phytomedicine 7:309-12. 2000
    ..The antispasmodic effect of khat extract was observed to be similar to that of D-amphetamine...
  66. ncbi Pancolonic motor response to subsensory and suprasensory sacral nerve stimulation in patients with slow-transit constipation
    P G Dinning
    Department of Human Physiology, Flinders University, Bedford Park, South Australia
    Br J Surg 99:1002-10. 2012
    Sacral nerve stimulation (SNS) is emerging as a potential treatment for patients with constipation. Although SNS can elicit an increase in colonic propagating sequences (PSs), the optimal stimulus parameters for this response remain ..
  67. ncbi Recent advances in chronic constipation
    Ritu Walia
    Department of Pediatric Gastroenterology and Nutrition, The Children s Hospital, Cleveland Clinic, Cleveland, Ohio44195, USA
    Curr Opin Pediatr 21:661-6. 2009
    Chronic constipation remains one of the most frequent complaints in primary and subspecialty pediatric clinics. It is associated with significant emotional and economic burden for both the children and the caregivers...
  68. pmc Manometric investigation of anorectal function in early and late stage Parkinson's disease
    G Bassotti
    Laboratorio di Motilità Intestinale, Sezione di Gastroenterologia ed Epatologia, Via Enrico Dal Pozzo, 06100 Perugia, Italy
    J Neurol Neurosurg Psychiatry 68:768-70. 2000
    Abnormal gastrointestinal function is relatively frequent in Parkinson's disease, and constipation is a disturbing symptom in many patients...
  69. pmc Autonomic nervous system activity in constipation-predominant irritable bowel syndrome patients
    Marcel Mazur
    Department of Pathophysiology, Jagiellonian University, Medical College, Cracow, Poland
    Med Sci Monit 18:CR493-499. 2012
    ..Autonomic nervous system dysfunction can contribute to development of irritable bowel syndrome symptoms by disturbing visceral sensations...
  70. pmc A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation
    Satish Rao
    Section of Gastroenterology Hepatology, Georgia Health Sciences University, Augusta, Georgia, USA
    Am J Gastroenterol 107:1714-24; quiz p.1725. 2012
    Linaclotide is a minimally absorbed guanylate cyclase-C agonist. The objective of this trial was to determine the efficacy and safety of linaclotide in patients with irritable bowel syndrome with constipation (IBS-C).
  71. pmc Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model
    Zi Huan Yang
    The School of Life Science, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 3:e3348. 2008
    Symptoms of constipation are extremely common, especially in the elderly...
  72. ncbi Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC)
    Y F Zhao
    Department of Health Statistics, Second Military Medical University, Shanghai, China
    Aliment Pharmacol Ther 34:1020-9. 2011
    The epidemiology and effects of functional constipation (FC) on Chinese people remain unclear.
  73. pmc Long-term safety and effectiveness of lubiprostone, a chloride channel (ClC-2) activator, in patients with chronic idiopathic constipation
    Anthony J Lembo
    Division of Gastroenterology, Harvard Medical School, 330 Brookline Ave, DA 501, Boston, MA, USA
    Dig Dis Sci 56:2639-45. 2011
    Lubiprostone helps relieve constipation in short-term 4-week studies. There are limited data on long-term pharmacological treatment with lubiprostone for chronic idiopathic constipation.
  74. ncbi Clinical and physiological findings, and possible aetiological factors of rectal hyposensitivity
    M A Gladman
    Academic Department of Surgery and Gastrointestinal Physiology Unit, St Bartholomew s and the London School of Medicine and Dentistry, London, UK
    Br J Surg 90:860-6. 2003
    ..Rectal hyposensitivity (RH) relates to insensitivity of the rectum on anorectal physiological investigation and appears common in functional bowel disorders. The clinical significance of this physiological abnormality is unclear...
  75. ncbi Breath hydrogen test after a bean meal demonstrates delayed oro-cecal transit time in children with chronic constipation
    Ana Cristina Fontenele Soares
    Pediatric Gastroenterology Division and the Medical Imaging Department, Federal University of Sao Paulo, Sao Paulo, Brazil
    J Pediatr Gastroenterol Nutr 41:221-4. 2005
    To evaluate oro-cecal transit time in children with chronic constipation.
  76. ncbi Clinical utility of colonic and anorectal manometry in chronic constipation
    Satish S C Rao
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Gastroenterol 44:597-609. 2010
    b>Constipation is one of the most common digestive problems in North America with significant psychosocioeconomic implications...
  77. ncbi Anorectal function and the effect of biofeedback therapy in ambulatory spinal cord disease patients having constipation
    Dong Hoon Yang
    Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Scand J Gastroenterol 45:1281-8. 2010
    b>Constipation in patients with mild spinal cord disease is not well investigated yet. We aimed to investigate anorectal function and the effect of biofeedback therapy in constipated patients with mild spinal cord diseases.
  78. ncbi Clinical and laboratory findings in 220 children with recurrent abdominal pain
    C F M Gijsbers
    Department of Paediatric Gastroenterology, Juliana Children s Hospital Haga Teaching Hospital, The Hague, The Netherlands
    Acta Paediatr 100:1028-32. 2011
    ..To investigate the clinical and laboratory findings in children with recurrent abdominal pain (RAP)...
  79. ncbi Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation
    Corinna Koebnick
    Department of Interventional Studies, German Institute of Human Nutrition, Bergholz Rehbrücke, Germany
    Can J Gastroenterol 17:655-9. 2003
    The aim of the present study was to investigate the effect of a probiotic beverage on gastrointestinal symptoms in patients with chronic constipation.
  80. pmc Effects of resistance and functional-skills training on habitual activity and constipation among older adults living in long-term care facilities: a randomized controlled trial
    Marijke J M Chin A Paw
    Department of Public and Occupational Health, EMGO Institute VU University Medical Center Van der Boechorststraat 7 1081 BT Amsterdam, The Netherlands
    BMC Geriatr 6:9. 2006
    ..in institutionalised older people are scarce, especially regarding effects on habitual physical activity and constipation. This study investigated the effects of different training protocols on habitual physical activity and ..
  81. ncbi A novel mutation in MED12 causes FG syndrome (Opitz-Kaveggia syndrome)
    P Rump
    Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Genet 79:183-8. 2011
    ..G958E). This is the first demonstration that other mutations in this gene can also lead to Opitz-Kaveggia syndrome. The clinical phenotype of these three new cases is reviewed in detail and compared with the previous reported cases...
  82. ncbi Quality of life in children with slow transit constipation
    Melanie C C Clarke
    Department of Surgical Research, Royal Children s Hospital, Parkville, Melbourne, Victoria 3052, Australia
    J Pediatr Surg 43:320-4. 2008
    Slow transit constipation (STC) causes intractable symptoms not readily responsive to laxatives, diet, or life-style changes...
  83. pmc Intestinal obstruction syndromes in cystic fibrosis: meconium ileus, distal intestinal obstruction syndrome, and constipation
    Hubert P J van der Doef
    Department of Pediatric Gastroenterology KE 04 133 1, University Medical Center Utrecht, Postbox 85090, 3508 AB Utrecht, The Netherlands
    Curr Gastroenterol Rep 13:265-70. 2011
    Meconium ileus at birth, distal intestinal obstruction syndrome (DIOS), and constipation are an interrelated group of intestinal obstruction syndromes with a variable severity of obstruction that occurs in cystic fibrosis patients...
  84. ncbi The nursing management of diarrhoea and constipation before and after the implementation of a bowel management protocol
    S McKenna
    Intensive Care Unit, St Vincent's Hospital, Sydney, NSW
    Aust Crit Care 14:10-6. 2001
    Intensive care unit (ICU) patients frequently suffer problems associated with both diarrhoea and constipation. Strategies to optimise the management of these conditions need to focus on improving the communication between staff and ..
  85. ncbi Chronic constipation in the elderly
    Juan F Gallegos-Orozco
    Division of Gastroenterology, Mayo Clinic in Arizona, Scottsdale, 85259, USA
    Am J Gastroenterol 107:18-25; quiz 26. 2012
    b>Constipation is one of the most frequent gastrointestinal disorders encountered in clinical practice in Western societies. Its prevalence increases with age and is more frequently reported in female patients...
  86. ncbi Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome: a randomized, placebo-controlled and dose-finding study
    S Fukudo
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neurogastroenterol Motil 23:544-e205. 2011
    ..The aim of this work was to perform a dose-finding study for lubiprostone for the treatment of constipation with or without irritable bowel syndrome (IBS) in Japan.
  87. ncbi Use of health care resources and cost of care for adults with constipation
    Gurkirpal Singh
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA
    Clin Gastroenterol Hepatol 5:1053-8. 2007
    b>Constipation is a multisymptom disorder that frequently compromises quality of life and leads patients to seek medical advice...
  88. ncbi Efficacy of an herbal dietary supplement (Smooth Move) in the management of constipation in nursing home residents: A randomized, double-blind, placebo-controlled study
    Sam Bub
    Cedarbrook Nursing Home, Allentown, PA, USA
    J Am Med Dir Assoc 7:556-61. 2006
    To investigate the efficacy and cost effectiveness of an herbal tea, Smooth Move, in nursing home residents with chronic constipation.
  89. ncbi Generalized transit delay on wireless motility capsule testing in patients with clinical suspicion of gastroparesis, small intestinal dysmotility, or slow transit constipation
    Braden Kuo
    Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA
    Dig Dis Sci 56:2928-38. 2011
    The prevalence of generalized transit delay and relation to symptoms in suspected gastroparesis, intestinal dysmotility, or slow transit constipation are unknown.
  90. ncbi Sacral nerve stimulation for intractable constipation
    Michael A Kamm
    University Department of Medicine, St Vincent s Hospital, Victoria Parade, Fitzroy, Melbourne 3065, Australia
    Gut 59:333-40. 2010
    Traditional surgical procedures for intractable idiopathic constipation are associated with a variable outcome and substantial morbidity...
  91. ncbi Presence of cholinergic and calcium channel blocking activities explains the traditional use of Hibiscus rosasinensis in constipation and diarrhoea
    Anwar H Gilani
    Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan
    J Ethnopharmacol 102:289-94. 2005
    ..extract contains spasmogenic and spasmolytic constituents mediating their effect through cholinergic receptors activation and blockade of Ca(2+) influx, respectively, which may explain its traditional use in constipation and diarrhoea.
  92. ncbi Effect of alosetron on bowel urgency and global symptoms in women with severe, diarrhea-predominant irritable bowel syndrome: analysis of two controlled trials
    Anthony J Lembo
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Clin Gastroenterol Hepatol 2:675-82. 2004
    ..The aim of this study was to assess the effect of alosetron on bowel urgency and irritable bowel syndrome (IBS) global improvement in diarrhea-predominant IBS (D-IBS)...
  93. ncbi Prescriptions of Chinese herbal medicine for constipation under the national health insurance in Taiwan
    Maw Shiou Jong
    Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R O C
    J Chin Med Assoc 73:375-83. 2010
    b>Constipation is a common gastrointestinal problem worldwide...
  94. ncbi Constipation in children: an epidemiological study in Sri Lanka using Rome III criteria
    Shaman Rajindrajith
    Department of Paediatrics, Faculty of Medicine, University of Kelaniya, Talagolla Road, Ragama 11010, Sri Lanka
    Arch Dis Child 97:43-5. 2012
    b>Constipation is a common paediatric problem, but its prevalence in Asia is unknown...
  95. ncbi Randomised clinical trial: The ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation--a double-blind study
    M Simren
    Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Aliment Pharmacol Ther 34:41-50. 2011
    One half of patients with constipation are not satisfied with available therapies, hence there is a need for more effective and well-tolerated drugs.
  96. ncbi Effects of herbal medicine Dai-Kenchu-to on anorectal function in children with severe constipation
    N Iwai
    Division of Surgery, Children s Research Hospital, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Eur J Pediatr Surg 17:115-8. 2007
    We administered the herbal medicine Dai-Kenchu-To (DKT) to children with severe chronic constipation or with severe constipation after surgery for anorectal malformations...
  97. pmc Constipation and diarrhoea - common adverse drug reactions? A cross sectional study in the general population
    Gunvor S Fosnes
    Department of Medicine, Innlandet Hospital Trust, Gjøvik, Norway
    BMC Clin Pharmacol 11:2. 2011
    b>Constipation and diarrhoea are common complaints and often reported as adverse drug reactions. This study aimed at finding associations between drugs and constipation and diarrhoea in a general population.
  98. ncbi Constipation: a potential cause of pelvic floor damage?
    C Amselem
    Pelvic Floor Institute, Barcelona, Spain
    Neurogastroenterol Motil 22:150-3, e48. 2010
    Pelvic floor damage is a major clinical problem usually attributed to obstetric injury. We speculated that constipation may also be an aetiological and preventable factor resulting from repeated stress on the perineum over many years, and ..
  99. ncbi Functional magnetic stimulation in constipation associated with Parkinson's disease
    Cheng Ming Chiu
    Department of Physical Medicine and Rehabilitation, Far Eastern Memorial Hospital, Taipei, Taiwan, ROC
    J Rehabil Med 41:1085-9. 2009
    ....
  100. ncbi Small cell ovarian carcinoma: a rare, aggressive tumor masquerading as constipation in a teenager with a fatal outcome
    Jesse Barondeau
    Department of Pediatrics, Madigan Army Medical Center, Tacoma, WA, USA
    J Pediatr Hematol Oncol 32:e139-41. 2010
    A 16-year-old female presented with symptoms consistent with constipation with no constitutional symptoms. Multiple different laxatives were attempted over 4 months and were unsuccessful...
  101. ncbi Rectal hyposensitivity: prevalence and clinical impact in patients with intractable constipation and fecal incontinence
    Marc A Gladman
    Academic Department of Surgery and Gastrointestinal Physiology Unit, Barts and The London, Queen Mary s School of Medicine and Dentistry, United Kingdom
    Dis Colon Rectum 46:238-46. 2003
    ..The purpose of this study was to determine the prevalence of rectal hyposensitivity and whether the finding of such an abnormality was associated with any clinical impact...

Research Grants76

  1. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..Disorders of any of these components result in abnormal motility patterns that cause diarrhea or constipation and associated disturbances in absorption of nutrients and water from the gut...
  2. Effects of spinal cord injury on vagal afferents from the rat bladder and colon.
    April N Herrity; Fiscal Year: 2013
    ..Patients develop a neurogenic bowel that includes constipation, fecal impaction and incontinence, and increased pain from abdominal distention 66;68;60...
  3. Iyengar yoga for adolescents and young adults with irritable bowel syndrome
    Subhadra Evans; Fiscal Year: 2013
    ..Symptoms include discomfort in the abdomen, along with diarrhea and/or constipation and other gastroenterological symptoms, which can significantly impact quality of life and daily functioning of ..
  4. Novel Phosphate Binder: Effects on Hyperphosphatemia, Vascular Calcification & Bo
    DEANNA J contact NELSON; Fiscal Year: 2010
    ..to a host of problems, including side effects that run the gamut of poor taste, halitosis, gastric bloating, constipation, the number of pills, and cost...
  5. Modulation of Colonic Epithelial Permeability by Sex Hormones
    Muriel Larauche; Fiscal Year: 2013
    ..sex differences in the alterations of colonic mucosal neuroimmune functions in relation with abdominal pain and constipation symptoms in IBS patients has not been investigated...
  6. Epigenetic regulation of stem cell senescence in aging
    DAVID TOCHUKWU ASUZU; Fiscal Year: 2011
    ..Age-related changes in the GI tract include increased gastroesophageal reflux, irritable bowel syndrome, constipation and fecal incontinence, as well as more subtle dysfunctions such as inability to consume large volumes of food...
  7. Improving pain and function in hip fracture
    R Sean Morrison; Fiscal Year: 2013
    ..g., constipation, delirium, sedation, nausea, respiratory depression) and studies suggest that older adults receive ..
  8. Stem cells for novel gene delivery of nitric oxide in the gut
    Hiroshi Mashimo; Fiscal Year: 2013
    ..of gastrointestinal motility disorders including achalasia, diabetic gastroparesis, pyloric stenosis, chronic constipation, and Hirschsprung's Disease...
  9. Bile Acids, Genetic Control and Colonic Function in Irritable Bowel Syndrome
    MICHAEL L CAMILLERI; Fiscal Year: 2013
    ..is reported in 20-75% of patients with chronic diarrhea;BA deficiency is reported in rare cases of childhood constipation. We have previously used microarray and confirmatory qRT-PCR to quantify the expression in colorectal mucosa of ..
  10. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2013
    ..been shown to cause diseases causing difficulty in swallowing, gastric stasis, dyspepsia, intestinal stasis and constipation. Defective NO neurotransmission is also implicated in diabetic gastroparesis and functional disorders of the ..
  11. Ednrb Regulation of Gastrointestinal Motility
    KENT CHARLES WILLIAMS; Fiscal Year: 2013
    ..and for other patient populations that suffer from gastroesophageal reflux, irritable bowel syndrome, and constipation. Three specific aims are proposed: Aim 1 will compare the structure and function of the ENS in the small ..
  12. Regulation of gastrointestinal neuromuscular function by NIBP/NFkB signaling
    Wenhui Hu; Fiscal Year: 2013
    ..associated with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), gastroparesis and chronic constipation/diarrhea...
  13. PSYCHOPHYSIOLOGY OF IRRITABLE BOWEL SYNDROME
    William E Whitehead; Fiscal Year: 2012
    ..than 50 physiological and psychological variables in 267 IBS patients and identified 4 independent clusters: constipation- predominant (IBS-C), diarrhea-predominant (IBS-D), pain-hypersensitive (IBS-Pn), and psychologically ..
  14. Opioid tolerance and bowel dysfunction
    William L Dewey; Fiscal Year: 2013
    ..in man is limited by side-effects that include analgesic tolerance and opioid-induced bowel dysfunction, with constipation being the most common and debilitating symptom...
  15. Mechanisms of Altered Gastrointestinal Dysfunction
    QiQi Zhou; Fiscal Year: 2013
    ..with irritable bowel syndrome (IBS) suffer from chronic abdominal pain and associated GI symptoms - diarrhea, constipation, bloating &urgency...
  16. ET3-EDNRB Signaling in Enterocolitis Associated with Colonic Aganglionosis
    PHILIP KENT FRYKMAN; Fiscal Year: 2013
    ..g., severe constipation, diarrhea, intestinal inflammation) that predispose to sepsis, and can be life-threatening...
  17. Impact of Family History of Colon Cancer on Adenomas in 40-49 Year Olds
    Philip S Schoenfeld; Fiscal Year: 2012
    ..e., constipation or diarrhea) as their indication for colonoscopy;(B) Identify risk factors associated with advanced adenomas or ..
  18. Are Autism Spectrum Disorders Associated with Leaky-Gut at an Early Critiacal Per
    Geert W Schmid-Schoenbein; Fiscal Year: 2013
    ..g., diarrhea, reflux, constipation), 3) diet (breast-milk vs...
  19. TMS in the Management of Postoperative Pain
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..use including respiratory depression, nausea and vomiting, cough suppression, mental clouding, sedation and constipation, and many of these side-effects are particularly problematic in gastric-bypass surgery patients who tend to ..
  20. Enteric nervous system deficits in Hirschsprung ganglionic bowel
    MELISSA MUSSER; Fiscal Year: 2013
    ..disorders are a substantial clinical burden with more than 25% of pediatric GI referrals arising from chronic constipation and 63 million people in the US alone suffering from chronic constipation...
  21. Symptom management for irritable bowel syndrome constipation (IBS-C)
    Joyce K Anastasi; Fiscal Year: 2013
    ..183 adults, diagnosed with IBS-Constipation (IBS-C) based on the ROME III criteria, will be randomized to one of three conditions: 1) Protocol-oriented Acu/..
  22. The influence of diabetes on M2 muscarinic receptor contractile function
    KIRK JIHYON PAK; Fiscal Year: 2012
    ..with diabetes commonly display aberrant urogenital (voiding dysfunction) and gastrointestinal (Gl) function (constipation and diarrhea), which may be caused, in part, by autonomic neuropathic changes and altered smooth muscle ..
  23. Engineered Opioid Receptors as Therapeutic Agents for Pain Control
    Ping Yee Law; Fiscal Year: 2012
    ..Unfortunately, their uses have been associated with many troublesome side effects such as nausea, constipation, respiratory depression, sedation, pruritus, tolerance and dependence development...
  24. A NURSING STUDY OF GUT FUNCTION IN MENSTRUATING WOMEN
    Margaret McLean Heitkemper; Fiscal Year: 2013
    ..loading), in three groups: moderate to severe diarrhea-predominant IBS versus women with moderate to severe constipation-predominant IBS versus control women;3) test the relationship between vagal tone and rectal hypersensitivity in ..
  25. Crystallization and structure determination of the mu-opioid receptor
    Roger K Sunahara; Fiscal Year: 2012
    ..have various adverse and sometimes fatal side-effects including nausea, respiratory depression, addiction, and constipation. A major impediment to the development of drugs that can achieve anti-nociception without the concomitant side ..
  26. Novel Treatment Strategies for Constipation and Role of Brain-Gut axis
    SATISH SC RAO; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Constipation affects up to 20% of the US population, mainly women and the elderly. Affected individuals experience impaired quality of life and most are dissatisfied with current therapy...
  27. AEROSOL FUROSEMIDE FOR DYSPNEA RELIEF: LABORATORY AND CLINICAL STUDIES
    Robert B Banzett; Fiscal Year: 2013
    ..Opiates carry many disadvantages including depression of respiration, confusion, nausea and constipation. Inhaled furosemide aerosol has shown promise in relieving dyspnea with none of these side effects...
  28. Formation of the Enteric Nervous System
    Chen Ming Fan; Fiscal Year: 2013
    ..Deficiency of enteric neurons causes abdominal distention and constipation, a condition of patients suffering from the Hirschsprung's disease...
  29. Treatment of SLE with ajulemic acid, a non-psychoactive cannabinoid derivative
    Meggan Mackay; Fiscal Year: 2013
    ..potential toxicitie including gastrointestinal bleeding and kidney toxicity in the case of NSAIDS, somnolence, constipation and nausea for narcotics and osteoporosis, osteonecrosis, diabetes, cataracts and atherosclerosis for ..
  30. Functional Relevance of CFTR Trafficking in Vivo to Intestinal Disease
    Nadia A Ameen; Fiscal Year: 2013
    ..factors and mechanisms regulating CFTR in the intestine under homeostatic and pathophysiologic conditions and extend insights into CFTR trafficking mechanisms that can be targeted to treat common intestinal diseases such as constipation.
  31. Analgesics targeting truncated 6transmembrane exon 11 variants of MOR-1 (6TM-E11)
    Susruta Majumdar; Fiscal Year: 2013
    ..Despite it potent analgesic actions, IBNtxA lacks respiratory depression, significant constipation, physical dependence or reward...
  32. Intestinal Epithelia Ammonium Transport
    Roger T Worrell; Fiscal Year: 2012
    ..tract are characterized by the dysregulation of ion and fluid transport resulting in diarrhea or constipation. Over the past fifty years, a plethora of studies have focused on possible mechanisms and treatments for these ..
  33. Development of NMUR2 Antagonists as Novel Analgesics
    NEIL CUTSHALL; Fiscal Year: 2013
    ..However, these drugs produce severe and unwanted side effects, such as respiratory depression, nausea, constipation and tolerance development (Berde et al, 2008);in addition, they are highly addictive (Koob et al, 1998)...
  34. Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a Fo
    Gregory Scherrer; Fiscal Year: 2011
    ..e. paradoxical hyperalgesia, drug abuse, vomiting, constipation, respiratory depression, etc) and have limited efficacy for the treatment of certain types of chronic pain (i.e...
  35. Mu opioid agonists with reduced side effects for the treatment of pain
    Chad E Groer; Fiscal Year: 2011
    ..receptor (MOR);however, this receptor also mediates unwanted opioid side-effects such as tolerance, dependence, constipation and overdose...
  36. Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a Fo
    Gregory Scherrer; Fiscal Year: 2013
    ..e. paradoxical hyperalgesia, drug abuse, vomiting, constipation, respiratory depression, etc) and have limited efficacy for the treatment of certain types of chronic pain (i...
  37. Assay for GI Drug Discovery
    LID WONG; Fiscal Year: 2012
    ..are the two predominant drug discovery gastrointestinal (GI) target sites for the treatments of diarrhea, constipation and gastric reflux...
  38. Obstruction-initiated mechanotranscription in colonic smooth muscle cells
    Xuan Zheng Shi; Fiscal Year: 2012
    ..hypertrophy), and are responsible for symptoms such as abdominal bloating, vomiting, abdominal cramps, and constipation, and may lead to intestinal failure...
  39. DEVELOPMENT OF RECEPTOR-SPECIFIC OPIOID PEPTIDE ANALOGS
    Peter W Schiller; Fiscal Year: 2013
    ..Their propensities to produce analgesic tolerance, physical dependence, constipation and respiratory depression will be examined...
  40. The Human Microbiome in Pediatric Abdominal Pain and Intestinal Inflammation
    James Versalovic; Fiscal Year: 2012
    ..In addition to the detailed clinical assessment of healthy children and children with irritable bowel syndrome, constipation, and inflammatory bowel disease (Crohn disease), multiple strategies will be deployed to navigate and ..
  41. Analgesic Potential of NOP Agonists to Treat Pain in Sickle Cell Disease
    Nurulain T Zaveri; Fiscal Year: 2012
    ..pain relief in sickle cell pain, without the liabilities associated with opioid- based therapies, such as constipation, tolerance and dependence...
  42. Palliative Care Symptom Management in Rural Communities
    Ardith Z Doorenbos; Fiscal Year: 2013
    ..Palliative care aims to provide relief of pain and other patient symptoms, such as fatigue, dyspnea, constipation, anxiety, and depression, in order to improve quality of life...
  43. Randomized placebo-controlled trial of glutamine for patients with IBS
    G Nicholas Verne; Fiscal Year: 2012
    ..IBS patients suffer from chronic abdominal pain associated with diarrhea, constipation, and/or bloating (Verne &Cerda, 1997)...
  44. Conservative Treatment of Fecal Incontinence in the Elderly: Effectiveness T
    William E Whitehead; Fiscal Year: 2013
    ..behavioral strategies for preventing FI, and use of fiber or nonprescription medication to treat diarrhea or constipation. To minimize drift when the treatment is disseminated to a large group of providers, patient education and ..
  45. Peripheral activation of Group III mGluR potentiates morphine analgesia
    ALYSSA LANE BAKER; Fiscal Year: 2013
    ..Major issues accompany opiate use including respiratory depression, tolerance, constipation, insomnia, and nausea...
  46. Zebrafish Based Model for Gastrointenstinal Physiology
    ADAM J RICH; Fiscal Year: 2010
    ..to help identify novel drug targets for the effective treatment of gastrointestinal motility disorders such as constipation, gastroparesis, and bloating...
  47. Mechanism of Diabetic Enteric Neuropathy
    SHANTHI K SRINIVASAN; Fiscal Year: 2013
    ..One major complication of DM is neuropathies. Constipation is a key consequence of enteric neuropathy and is significantly more common in DM patients with a prevalence of ..
  48. Computer Assisted Symptom Management for Patients Receiving Radiation Therapy
    Erik K Fromme; Fiscal Year: 2010
    ..experience significant symptoms such as pain, nausea, dyspnea, fatigue, insomnia, anxiety, depression, constipation, and anorexia...
  49. Ligands that target opioid-chemokine and opioid-mGlu5 heteromers
    Philip S Portoghese; Fiscal Year: 2013
    ..increase the efficacy of morphine and prevent the establishment of side effects such as tolerance, dependence, constipation, etc., under inflammatory conditions...
  50. Structural Approaches for Understanding Opioid and ??-Receptor Interactions
    Renyu Liu; Fiscal Year: 2013
    ..for perioperative and chronic pain management, but their side effects, which include respiratory depression, constipation, addiction and others, relate to morbidity and mortality in our patients, as well as presenting a significant ..
  51. Identification of agents to enhance colonic motility in the elderly
    Michael A Pack; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Constipation is common in the elderly and in many patients it is a significant problem that affects quality of life...
  52. Mobile e-Health dietary fiber calculator for self-management of IBS
    Lisa A Russell; Fiscal Year: 2012
    ..Several reviews have concluded that soluble fiber may be more effective than insoluble fiber for constipation, and insoluble fiber may worsen some symptoms...
  53. Relex Pathways Controlling Intestinal Motility
    TERENCE KEITH SMITH; Fiscal Year: 2012
    ..The mechanisms underlying colonic storage and slow transit have remained elusive. Slow transit constipation (STC) has been associated with colonic elongation and other changes, including an excess production of nitric ..
  54. New Strategies to Treat Overactive Bladder
    Changfeng Tai; Fiscal Year: 2013
    ..treatment within 6-12 months due to its moderate efficacy and significant adverse effects such as dry mouth, constipation, headache, and blurred vision...
  55. Synthesis and Evaluation of Functionally Biased Opioid Analgesics
    Laura M Bohn; Fiscal Year: 2013
    ..However, this receptor is also the means by which these drugs produce unwanted effects such as constipation, dependence and addiction...
  56. Pharmacological Studies of NOP Receptors
    Mei Chuan Ko; Fiscal Year: 2013
    ..used opioids for the treatment of moderate to severe pain in the clinic, the side effects of mu opioids such as constipation, respiratory depression, pruritus, abuse liability, and physical dependence limit their value as a medication...
  57. Peripheral FAAH as a target for novel analgesics
    Miguel Garcia-Guzman; Fiscal Year: 2013
    ..Clinically used analgesics cause a series of common side effects that include gastric irritation, constipation and sedation. Previous work in our lab has shown that URB937 produces no gastric irritation after oral dosing...
  58. Managing Medication-induced Constipation in Cancer: A Clinical Trial
    Susan C McMillan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Constipation is a very common problem among cancer patients and although it is very amenable to nursing intervention, constipation often goes unrecognized and untreated...
  59. GUCY2C hormone suppression links obesity with colorectal cancer
    ERIK BLOMAIN; Fiscal Year: 2013
    ..The potential for immediate translation of these results to mitigate colorectal cancer risk in obese patients can be appreciated in the context of the recent regulatory approval of oral GUCY2C ligands to treat constipation.
  60. An Implantable Pacemaker Optimized for Smooth Muscle Stimulation
    ROBERT ARTHUR ROSS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Constipation is a common symptom affecting between 2 percent and 27 percent of the population in Western countries. In the United States, it results in more than 2...
  61. Implementing best practice in palliative care
    Amy P Abernethy; Fiscal Year: 2013
    ..One example of low conformance with quality metrics identified in QDACT-PC was related to constipation management;data demonstrate that less than 50% of patients are receiving current best practice interventions to ..
  62. Agonist-Directed MOR Desensitization in Opioid Analgesic Tolerance
    Laura M Bohn; Fiscal Year: 2010
    ..Mice that lack ?arrestin2 also display significantly reduced morphine-associated side effects, such as constipation and respiratory suppression...
  63. SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEM
    KATHY LEPARD; Fiscal Year: 2001
    ..patients often experience a wide range of GI discomforts including heartburn, nausea, vomiting, diarrhea, constipation, fecal incontinence and abdominal pain...
  64. Endogenous Hormones and Risk of Endometriosis
    Stacey Missmer; Fiscal Year: 2009
    ..Establishment of follow-up among our younger cohort will provide resources for the first prospective study of endometriosis among adolescents. ..
  65. NC/OFQ analogs as ORL1 agonists to promote gut motility
    MARK FINDEIS; Fiscal Year: 2005
    ..ileus (POI) with further utility for the treatment of other Gl motilityrelated disorders, particularly severe constipation. POI is a condition characterized by a lack of bowel motility, abdominal pain, and nausea...
  66. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2007
    ..the effects of opiates, potent drugs used for pain control, including analgesia, opioid bowel syndrome (constipation and abdominal pain), and tolerance...
  67. MALE UROGENITAL FUNCTION AND CHRONIC SPINAL CORD INJURY
    Charles Hubscher; Fiscal Year: 2009
    ..In many patients, conscious control of defecation is also lost resulting in fecal incontinence and chronic constipation. Since normal ejaculation, micturition, and defecation require sequential contraction of perineal muscles that ..
  68. A prospective study of diet and endometriosis
    Stacey Missmer; Fiscal Year: 2006
    ..These analyses will be the first to evaluate the relation between these dietary factors and this important and understudied cause of morbidity among premenopausal women. [unreadable] [unreadable]..
  69. DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATION
    ALAN HOFMANN; Fiscal Year: 2005
    b>Constipation in children is a common, vexing problem for the patient, his or her parents, and the pediatric gastroenterologist. Most cases have no discernible organic cause...
  70. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
    ..of developmental disorders of the enteric nervous system including Hirschsprung's disease, slow transit constipation and infantile hypertrophic pyloric stenosis...
  71. Ret Signaling in Paraneoplastic Peripheral Neuropathy
    JOSEPHINE FOX; Fiscal Year: 2009
    ..c-RET signaling in neurons, which results in clinical symptoms of chronic thyroid disease, such as slow transit constipation and muscle weakness...
  72. IDENTIFICATION & ANALYSES OF THE UROFACIAL SYNDROME GENE
    Jin Xiong She; Fiscal Year: 2001
    ..is an autosomal recessive disease characterized by congenital obstructive uropathy due to a neurogenic bladder, constipation and abnormal facial expression. Pedigree analysis has shown that a single gene is responsible for the syndrome...
  73. The Human Microbiome in Pediatric Abdominal Pain and Intestinal Inflammation
    James Versalovic; Fiscal Year: 2009
    ..In addition to the detailed clinical assessment of healthy children and children with irritable bowel syndrome, constipation, and inflammatory bowel disease (Crohn disease), multiple strategies will be deployed to navigate and ..
  74. Acetylcholine in Diabetic Enteric Nervous System
    KATHY LEPARD; Fiscal Year: 2004
    Diabetics report a greater frequency of constipation, diarrhea, urgency, and fecal incontinence than the general population that may reflect alterations in gastrointestinal (GI) motility due to neuropathy of autonomic nerves...
  75. CONTRACTILE SIGNAL TRANSDUCTION IN ULCERATIVE COLITIS
    Weibiao Cao; Fiscal Year: 2004
    ..the muscle layer, leading to motor dysfunction, which contributes to key clinical symptoms, including diarrhea, constipation, and crampy abdominal pain...
  76. ORPHANIN FQ (OFQ) EFFECTS ON RAT COLONIC MOTILITY
    Toku Takahashi; Fiscal Year: 2003
    ..This may have important clinical implications since OFQ or its analogues may be beneficial for the treatment of refractory constipation in humans.