cyanosis

Summary

Summary: A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin in the blood or a structural defect in the hemoglobin molecule.

Top Publications

  1. ncbi Vascular endothelial growth factor in children with congenital heart disease
    Yoshio Ootaki
    Department of Cardiothoracic Surgery, Kobe Children s Hospital, Kobe, Hyogo, Japan
    Ann Thorac Surg 75:1523-6. 2003
  2. ncbi Cardiopulmonary bypass-induced myocardial reoxygenation injury in pediatric patients with cyanosis
    P Modi
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 124:1035-6. 2002
  3. pmc A hemoglobin variant associated with neonatal cyanosis and anemia
    Moira A Crowley
    Division of Neonatology, Case Western Reserve University, Cleveland, USA
    N Engl J Med 364:1837-43. 2011
  4. ncbi Cyanosis after Kawashima-Fontan: hybrid approach to mixing and matching flows
    Larry A Latson
    Pediatrics Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Thorac Surg 92:e81-3. 2011
  5. ncbi Partial hepatic vein diversion in pulmonary arteriovenous malformations in congenital heart disease
    Enrico Aidala
    Department of Pediatric Cardiac Surgery, Ospedale Infantile Regina Margherita, Torino, Italy
    Ann Thorac Surg 78:1089-90. 2004
  6. ncbi Regression of severe pulmonary arteriovenous malformations after Fontan revision and "hepatic factor" rerouting
    Nancy A Pike
    Division of Cardiothoracic Surgery, David Geffen School of Medicine at University of California Los Angeles, UCLA Box 951741, Los Angeles, CA 90095 1741, USA
    Ann Thorac Surg 78:697-9. 2004
  7. ncbi Chronic cyanosis and vascular function: implications for patients with cyanotic congenital heart disease
    Rachael L Cordina
    Department of Cardiology, Royal Prince Alfred Hospital and University of Sydney, Australia
    Cardiol Young 20:242-53. 2010
  8. ncbi Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival
    Konstantinos Dimopoulos
    Adult Congenital Heart Programme, Department of Cardiology, Royal Brompton Hospital, Sydney St, London, SW3 6NP, United Kingdom
    Circulation 113:2796-802. 2006
  9. ncbi Cyanotic congenital heart disease and coronary artery atherogenesis
    Alistair Fyfe
    Dallas Heart Group, Dallas, TX, USA
    Am J Cardiol 96:283-90. 2005
  10. ncbi Methemoglobinemia: an unusual cause of postoperative cyanosis
    Carryn M Anderson
    Division of Vascular Surgery, Department of Surgery, University of Texas Medical Branch, Boulevard, Galveston, TX 77555 0544, USA
    J Vasc Surg 39:686-90. 2004

Detail Information

Publications253 found, 100 shown here

  1. ncbi Vascular endothelial growth factor in children with congenital heart disease
    Yoshio Ootaki
    Department of Cardiothoracic Surgery, Kobe Children s Hospital, Kobe, Hyogo, Japan
    Ann Thorac Surg 75:1523-6. 2003
    ..This study determined whether children with cyanotic congenital heart disease have elevated serum levels of vascular endothelial growth factor (VEGF) and whether elevated VEGF correlated with these abnormal vessels...
  2. ncbi Cardiopulmonary bypass-induced myocardial reoxygenation injury in pediatric patients with cyanosis
    P Modi
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    J Thorac Cardiovasc Surg 124:1035-6. 2002
  3. pmc A hemoglobin variant associated with neonatal cyanosis and anemia
    Moira A Crowley
    Division of Neonatology, Case Western Reserve University, Cleveland, USA
    N Engl J Med 364:1837-43. 2011
    Globin-gene mutations are a rare but important cause of cyanosis. We identified a missense mutation in the fetal Gγ-globin gene (HBG2) in a father and daughter with transient neonatal cyanosis and anemia...
  4. ncbi Cyanosis after Kawashima-Fontan: hybrid approach to mixing and matching flows
    Larry A Latson
    Pediatrics Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Thorac Surg 92:e81-3. 2011
    ..Pulmonary arteriovenous malformations may form in the contralateral lung and result in severe cyanosis. We report a case of resolution of pulmonary arteriovenous malformations after successful rerouting of hepatic ..
  5. ncbi Partial hepatic vein diversion in pulmonary arteriovenous malformations in congenital heart disease
    Enrico Aidala
    Department of Pediatric Cardiac Surgery, Ospedale Infantile Regina Margherita, Torino, Italy
    Ann Thorac Surg 78:1089-90. 2004
    ..My colleagues and I describe a case of partial diversion of hepatic blood into the pulmonary circulation and suggest a strategy to decrease the likelihood of conduit thrombosis and to treat pulmonary arteriovenous malformations...
  6. ncbi Regression of severe pulmonary arteriovenous malformations after Fontan revision and "hepatic factor" rerouting
    Nancy A Pike
    Division of Cardiothoracic Surgery, David Geffen School of Medicine at University of California Los Angeles, UCLA Box 951741, Los Angeles, CA 90095 1741, USA
    Ann Thorac Surg 78:697-9. 2004
    ..We present a case in which successful H-type Fontan revision with rerouting of hepatic venous flow through a hemiazygous vein successfully reversed the progression of severe left pulmonary arteriovenous malformations...
  7. ncbi Chronic cyanosis and vascular function: implications for patients with cyanotic congenital heart disease
    Rachael L Cordina
    Department of Cardiology, Royal Prince Alfred Hospital and University of Sydney, Australia
    Cardiol Young 20:242-53. 2010
    ..Recent evidence suggests that deranged endothelial function, a sequel of chronic cyanosis, could be an important factor in the pathogenesis of cyanosis-associated cardiovascular risk...
  8. ncbi Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival
    Konstantinos Dimopoulos
    Adult Congenital Heart Programme, Department of Cardiology, Royal Brompton Hospital, Sydney St, London, SW3 6NP, United Kingdom
    Circulation 113:2796-802. 2006
    ..We sought to establish the distribution, relation to cyanosis, and prognostic value of the V(E)/V(CO2) slope across a wide spectrum of ACHD patients.
  9. ncbi Cyanotic congenital heart disease and coronary artery atherogenesis
    Alistair Fyfe
    Dallas Heart Group, Dallas, TX, USA
    Am J Cardiol 96:283-90. 2005
    ..The persistence of hypocholesterolemia after the surgical elimination of cyanosis suggests a genetic determinant.
  10. ncbi Methemoglobinemia: an unusual cause of postoperative cyanosis
    Carryn M Anderson
    Division of Vascular Surgery, Department of Surgery, University of Texas Medical Branch, Boulevard, Galveston, TX 77555 0544, USA
    J Vasc Surg 39:686-90. 2004
    ..although rare, must be considered in surgical patients presenting with acute respiratory distress and cyanosis. We report two cases of methemoglobinemia in patients undergoing aortic reconstruction...
  11. ncbi Congenital methemoglobinemia: a rare cause of cyanosis in the newborn--a case report
    Shonola S Da-Silva
    Division of Pediatric Critical Care Medicine, Children s Regional Hospital, University Medical Center, Camden, New Jersey 08103, USA
    Pediatrics 112:e158-61. 2003
    b>Cyanosis is a physical finding that can occur at any age but presents the greatest challenge when it occurs in the newborn...
  12. doi Chronic cyanosis, with polycythaemia and enlarged spleen: a new clinical entity. 1903
    William Osler
    Am J Med Sci 335:411-7. 2008
  13. ncbi An approach to diagnosis and management of cyanosis and tachypnea in term infants
    Ponthenkandath Sasidharan
    Department of Pediatrics, Division of Neonatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 51:999-1021, ix. 2004
    Tachypnea and cyanosis in the newborn are frequently encountered problems in the nursery. The incidence of respiratory distress ranges from 2.9% to 7.6%, and 4.3% of newborns may require supplemental oxygen therapy...
  14. pmc Iatrogenic cyanosis and clubbing: 25 years of chronic hypoxia after the repair of an atrial septal defect
    Muath Alanbaei
    MAUDE, McGill University, Montreal, Canada
    Can J Cardiol 23:901-3. 2007
    ..Long-standing, anatomical, right-to-left shunting with cyanosis and hypoxia are associated with systemic and cerebrovascular complications...
  15. ncbi Pulse oximetry in children with congenital heart disease: effects of cardiopulmonary bypass and cyanosis
    Adalberto Torres
    University of Illinois College of Medicine at Peoria, Illinois, USA
    J Intensive Care Med 19:229-34. 2004
    ..The Nellcor N-395 pulse oximeter failed more often immediately after cardiopulmonary bypass than did the Masimo SET Radical pulse oximeter. SpO2 measured with both oximeters overestimated SaO2 in the presence of persistent hypoxemia...
  16. ncbi The coronary microcirculation in cyanotic congenital heart disease
    Eduard I Dedkov
    Department of Anatomy and Cell Biology and Cardiovascular Center, University of Iowa Carver College of Medicine, Iowa City, USA
    Circulation 114:196-200. 2006
    ..We hypothesized that preservation of flow reserve resides in remodeling of the coronary microcirculation. Microcirculatory morphometric analyses were performed to test this hypothesis...
  17. ncbi Basal metabolic state of hearts of patients with congenital heart disease: the effects of cyanosis, age, and pathology
    Paul Modi
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 78:1710-6. 2004
    ..We conducted this study to specifically look at the effects of cyanosis, age, and pathology upon the basal metabolic state of the immature human heart.
  18. ncbi Changes in myocardial free amino acids during pediatric cardiac surgery: a randomised controlled trial of three cardioplegic techniques
    Paul Modi
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Eur J Cardiothorac Surg 30:41-8. 2006
    ..Blood cardioplegia preserves myocardial free AAs in adult hearts but no clinical studies have looked at the effect of different cardioplegic techniques on intracellular free AAs in the pediatric heart...
  19. ncbi Common congenital cyanotic heart defects--diagnosis and management
    M S Ranjit
    Sri Ramachandra Medical College and Research Institute, Deemed University, Chennai 600 116
    J Indian Med Assoc 101:71-2, 74. 2003
    ..These babies, if left untreated, deteriorate rapidly in hours. There lies the urgency of early diagnosis and management. The author has elaborated the issue, in brief, in this article...
  20. ncbi Bilateral pectoral myocutaneous advancement flaps and anatomic sternal wound reconstruction in cyanotic infants with mediastinitis
    Andras Kollar
    Department of Cardiac and Thoracic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Card Surg 18:245-52. 2003
    ....
  21. ncbi The clinical significance of the reoxygenation injury in pediatric heart surgery
    Bradley S Allen
    Division of Cardiovascular Surgery, The Heart Institute for Children, Hope Children s Hospital, Oak Lawn, IL 60453, USA
    Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 6:116-27. 2003
    ..this injury can be modified and possibly ameliorated by changes in the intraoperative management of cardiopulmonary bypass...
  22. ncbi Magnetic resonance imaging of cyanotic and noncyanotic congenital heart disease
    Fernando R Gutierrez
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Magn Reson Imaging Clin N Am 10:209-35. 2002
    ..A knowledge of the advantages and disadvantages of the different imaging sequences also is important so as to optimize and expedite the examination...
  23. ncbi Anomalous drainage of the inferior vena cava into the left atrium
    B E Kogon
    Department of Cardiothoracic Surgery, Emory University, Atlanta, GA 30322, USA
    Pediatr Cardiol 27:183-5. 2006
  24. ncbi The neonate with suspected congenital heart disease
    Michael E McConnell
    Sibley Heart Center Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA
    Crit Care Nurs Q 25:17-25. 2002
    ..Neonates with respiratory distress, cyanosis, feeding difficulties, low cardiac output, or dysmorphic syndromes commonly have CHD...
  25. ncbi Free amino acids in hearts of pediatric patients with congenital heart disease: the effects of cyanosis, age, and pathology
    Paul Modi
    Bristol Heart Institute, University of Bristol, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 81:943-9. 2006
    ..However, we have found no clinical studies that have looked at the free AA profile of the immature human heart or the effects of cyanosis, age, and pathology upon this.
  26. ncbi Gingival colonization with selective HACEK microbes in children with congenital heart disease
    Robert Steelman
    Department of Pediatrics, School of Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    Clin Oral Investig 7:38-40. 2003
    ..found that the greater extent of specific HACEK microbes harbored by children with CHD is not associated with cyanosis or the degree of gingival inflammation...
  27. ncbi Ventilatory effects of morphine infusions in cyanotic versus acyanotic infants after thoracotomy
    Anne M Lynn
    Department of Anesthesiology, University of Washington School of Medicine, Seattle, Washington, USA
    Paediatr Anaesth 13:12-7. 2003
    ..The presence of cyanotic heart disease in infants receiving postoperative morphine infusions was studied for its potential effect on ventilatory effort...
  28. ncbi Renal function and cardiac angiography
    Ayumi Niboshi
    Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamikyo ku Kyoto, Japan
    Indian J Pediatr 73:49-53. 2006
    ..To study the effect of non-ionic contrast medium on renal function in children with cardiovascular disease...
  29. ncbi Feasibility and safety of immediate perioperative implantation of intravascular stents in cavopulmonary pathways
    Muhammad Walayat
    Department of Cardiology, Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland
    Catheter Cardiovasc Interv 60:94-8; discussion 99-100. 2003
    ..We report the successful use of endovascular stents during the immediate postoperative period in patients undergoing cavopulmonary anastomoses...
  30. ncbi Venovenous extracorporeal membrane oxygenation for cyanotic congenital heart disease
    Michiaki Imamura
    Department of Pediatric and Congenital Heart Surgery, Arkansas Children s Hospital, Little Rock, AR 72202, USA
    Ann Thorac Surg 78:1723-7. 2004
    ..We examined our policy of venovenous extracorporeal membrane oxygenation support through the hypoxic event and performing delayed surgery, if required, to separate from extracorporeal membrane oxygenation...
  31. ncbi Associated factors and trends in outcomes of interrupted aortic arch
    Thomas Oosterhof
    Department of Pediatrics, Division of Cardiology, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 78:1696-702. 2004
    ..We sought to determine trends in presentation, management, outcomes and associated factors...
  32. ncbi Comparison between cerebral tissue oxygenation index measured by near-infrared spectroscopy and venous jugular bulb saturation in children
    Nicole Nagdyman
    Department of Congenital Heart Defects and Pediatric Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Intensive Care Med 31:846-50. 2005
    ..To compare the cerebral tissue oxygenation index (TOI) measured by near-infrared spectroscopy (NIRS) with venous oxygen saturation in the jugular bulb (SjO(2)) during elective cardiac catheterization in children...
  33. ncbi Change in plasma volume during peak exercise in patients with cyanotic congenital heart disease after definitive operation
    Hideo Ohuchi
    Department of Pediatrics, National Cardiovascular Center, Fujishiro dai, Suita, Osaka 565 8565, Japan
    Int J Cardiol 108:216-23. 2006
    To evaluate changes in plasma volume (deltaPV) during exercise in patients with single ventricular physiology with cyanosis; post-Fontan patients; and in patients after right ventricular outflow tract reconstruction (RVOTR).
  34. ncbi Increased vascular endothelial growth factor in patients with cyanotic congenital heart diseases may not be normalized after a Fontan type operation
    Kenji Suda
    Department of Pediatrics, Tenri Hospital, Tenri City, Japan
    Ann Thorac Surg 78:942-6; discussion 946-7. 2004
    ..To determine the change of serum concentration of vascular endothelial growth factor (VEGF) in patients with cyanotic congenital heart disease (C-CHD)...
  35. ncbi Transcatheter guidewire perforation of the pulmonary valve as a palliative procedure in pulmonary atresia with intact interventricular septum
    Robin I Pinto
    Glenmark Cardiac Centre, Mumbai
    Indian Heart J 56:661-3. 2004
    ..The technical challenges of performing this procedure in small infants are highlighted...
  36. ncbi Noninvasive monitoring of carbon dioxide in infants and children with congenital heart disease: end-tidal versus transcutaneous techniques
    John Wilson
    University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Intensive Care Med 20:291-5. 2005
    ..0001) and in patients < or = 1 year of age versus patients > or = 1 year of age (6 +/- 3 mm Hg vs 4 +/- 2, P = .008). In infants and children with CHD, TC monitoring provides a more accurate estimation of Pa(CO2) than ET monitoring...
  37. ncbi Positional cyanosis in infants: an unusual presentation of right-sided cardiac masses
    Aviva Levitas
    Pediatric Cardiology Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Cardiol Young 14:46-9. 2004
    Positional cyanosis is an uncommon finding in young patients. We report three infants who presented with positional cyanosis due to a pedunculated tumour in the right heart...
  38. ncbi Soluble P-selectin and thrombomodulin-protein C-Protein S pathway in cyanotic congenital heart disease with secondary erythrocytosis
    Hitoshi Horigome
    Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Thromb Res 112:223-7. 2003
    ....
  39. pmc Anomalous origin of the pulmonary artery from the left coronary artery
    S S Kothari
    Heart 89:1436. 2003
  40. ncbi Plasma leptin levels in children with cyanotic and acyanotic congenital heart disease and correlations with growth parameters
    Olgu Hallioglu
    Hacettepe University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Cardiology and Division of Pediatric Endocrinology, Ankara, Turkey
    Int J Cardiol 92:93-7. 2003
    ..The objective of this study was to examine the possible role of leptin on growth and nutrition in children with cyanotic and acyanotic congenital heart disease...
  41. ncbi Rigid bronchoscopy for the suspicion of foreign body in the airway
    Lutfi Barlas Aydogan
    Cukurova Universitesi Tip Fakultesi, Kulak Burun Bogaz Klinigi, Balcali, Adana 01330, Turkey
    Int J Pediatr Otorhinolaryngol 70:823-8. 2006
    ..Airway foreign bodies present a diagnostic dilemma and has been recognized for many years. Since aspiration of foreign bodies can be a serious and sometimes fatal problem, early intervention and proper management is vital...
  42. ncbi [The pharmacological manipulation of Botallo's duct in the duct-dependent congenital cardiopathies and in the preterm infants with respiratory distress. A review and personal findings]
    G Distefano
    Dipartimento di Pediatria, Universita degli Studi di Catania, Policlinico, Catania
    Minerva Pediatr 57:21-34. 2005
    ....
  43. ncbi The association of renal tubular acidosis and cyanotic congenital heart disease
    Vladimiro L Vida
    Department of Pediatric Cardiovascular Surgery, UNICAR, Guatemala City, Guatemala
    J Thorac Cardiovasc Surg 130:1466-7. 2005
  44. ncbi Does the site of insertion of a systemic-pulmonary shunt influence growth of the pulmonary arteries?
    Anjan S Batra
    Department of Pediatric Cardiology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Ann Thorac Surg 79:636-40. 2005
    ..The distal shunt anastomosis can be done to a branch pulmonary artery or to the main pulmonary artery. The purpose of this study was to determine if the site of shunt connection influences pulmonary artery growth...
  45. ncbi [Epidemiologic and clinical features of congenital heart diseases in children at the Bizerta Hospital]
    Olfa Hammami
    Service de Pediatrie, hôpital régional de Bizerte
    Tunis Med 85:829-33. 2007
    ..The aim of this study is to establish the epidemiologic profile of congenital heart disease in newborns in a Tunisian department of the north west of Tunisia...
  46. ncbi Neonatal Blalock-Taussig shunt: technical aspects and postoperative management
    Sunil K Swain
    Department of Pediatric Cardiac Surgery, Apollo Children s Heart Hospital, Hyderabad, India
    Asian Cardiovasc Thorac Ann 16:7-10. 2008
    ..Meticulous surgical technique and judicious use of heparin and inotropic agents improved the outcome and reduced the incidence of shunt blockage and reexploration for bleeding...
  47. ncbi Presentation of congenital heart disease in the neonate and young infant
    Michael Silberbach
    East Carolina University, Greenville, NC, USA
    Pediatr Rev 28:123-31. 2007
  48. ncbi Effects of hemodilution on outcome after modified Blalock-Taussig shunt operation in children with cyanotic congenital heart disease
    Tapan Kumar Sahoo
    Department of Cardiac Anesthesia and Cardiothoracic Surgery, All India Institute of Medical Sciences, New Delhi, India
    J Cardiothorac Vasc Anesth 21:179-83. 2007
    ..The aim of this study was to investigate similar beneficial effects of hemodilution in preventing shunt thrombosis and decreasing postoperative blood loss after modified Blalock-Taussig (BT) shunt operations in children with CCHD...
  49. ncbi [Assessment of the reasons prompting a first echocardiography in children: a Lebanese multicenter study]
    Ghassan Chehab
    Départements de Pédiatrie, CHU Hôtel Dieu de France, Achrafieh Beyrouth and Rafik Hariri University Hospital, Jnah Grand Beyrouth, Liban
    J Med Liban 55:2-10. 2007
    ..To study the different indications behind performance of a first Doppler echocardiography (DE) in children, to assess the results and their impact on the residency teaching program in Lebanon...
  50. ncbi The efficacy of preoperative administration of a single dose of recombinant human erythropoietin in pediatric cardiac surgery
    Yoshio Ootaki
    Department of Cardiothoracic Surgery, Kobe Children s Hospital, Kobe, Hyogo, Japan
    Heart Surg Forum 10:E115-9. 2007
    ..The purpose of this study was to evaluate the efficacy of administering a single dose of rHuEPO without blood donation in children undergoing pediatric cardiac surgery...
  51. ncbi Percutaneous management of cyanosis in Fontan patients using Amplatzer occluders
    Jozef Masura
    Children s Cardiac Center, University Children s Hospital, Bratislava, Slovakia
    Catheter Cardiovasc Interv 71:843-9. 2008
    To determine causes of cyanosis and to evaluate percutaneous management of cyanosis in a group of consecutive Fontan patients.
  52. ncbi Serum IGF-1, IGFBP-3 and growth hormone levels in children with congenital heart disease: relationship with nutritional status, cyanosis and left ventricular functions
    Ener Cagri Dinleyici
    Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey
    Neuro Endocrinol Lett 28:279-83. 2007
    ..in children with congenital heart disease (CHD) and to determine if these parameters have any relationship to the cyanosis, nutritional status and the left ventricular systolic function...
  53. doi Atrial septal stent implant: atrial septal defect creation in the management of complex congenital heart defects in infants
    Glenn T Leonard
    Lillie Frank Abercrombie Section of Cardiology, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
    Congenit Heart Dis 1:129-35. 2006
    ..We describe a series of patients, ranging in age from 5 weeks to 17 months, in whom we implanted a stent across the atrial septum to create a lasting, unrestrictive interatrial communication...
  54. ncbi Cerebral malaria in children with cyanotic heart diseases: the need for a closer look
    John Okeniyi
    Obafemi Awolowo University, Department of Pediatrics and Child Health College of Health Science, Osun State, Nigeria
    Congenit Heart Dis 3:73-6. 2008
    ..We also inferred that children with cyanotic cardiac defects may be prone to cerebral malaria and that those residing in the tropics may benefit from anti-malarial prophylaxis...
  55. ncbi Device occlusion of Fontan fenestration--an economical alternative
    Rajasekaran Prem Sekar
    The Department of Pediatric Cardiology, International Center for Cardio Thoracic and Vascular Diseases, R 30 C Ambattur Industrial Estate Road, Mogappair, Chennai 600101, India
    Asian Cardiovasc Thorac Ann 15:e55-7. 2007
    ..The marked improvement in the patient's clinical status immediately and after 3 months confirms this device to be a safe, and economically better alternative to the atrial septal defect occluder...
  56. pdf Congenital heart disease in Nepalese children
    N B Basnet
    Children s Medical Diagnosis Center, Kathmandu, Nepal
    JNMA J Nepal Med Assoc 45:281-2. 2006
    ..Present data indicate the need for increased levels of cardiac care in children, correctional surgeries, monitoring of the patients and awareness among caregivers of CHD patients...
  57. ncbi Rheolytic mechanical thrombectomy for pulmonary artery thrombus in children with complex cyanotic congenital heart disease
    Shaji C Menon
    Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Catheter Cardiovasc Interv 71:237-43. 2008
    ..We report three patients with complex congenital heart disease of single ventricle physiology palliated by cavopulmonary anastomosis or central shunts and PA thrombosis treated with AngioJet system...
  58. ncbi Univentricular heart
    Paul Khairy
    Adult Congenital Heart Center, Montreal Heart Institute, 5000 Belanger St, Montreal, Quebec, H1T 1C8, Canada
    Circulation 115:800-12. 2007
    ..Although the present report touches on issues applicable to neonates and children with univentricular hearts, the focus is on information of interest and relevance to the adult cardiologist...
  59. ncbi Stent implantation into the patent ductus arteriosus in cyanotic congenital heart disease with duct-dependent or diminished pulmonary circulation
    Ahmet Celebi
    Department of Pediatric Cardiology, Dr Siyami Ersek Thoracic and Cardiovascular Surgery Center and Research Hospital, Istanbul, Turkey
    Turk J Pediatr 49:413-7. 2007
    ..All patients in whom stent implantation was successful had adequate relief of their cyanosis and were discharged home. During a mean follow-up of 9...
  60. ncbi Correlation between vascular endothelial growth factor and leptin in children with cyanotic congenital heart disease
    Halil Ibrahim Aydin
    Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey
    Turk J Pediatr 49:360-4. 2007
    ..207, p=0.211) in the cyanotic group. There was no correlation between VEGF, leptin and SaO2 in the acyanotic group. We conclude that it is likely that both VEGF and leptin have a role in the pathogenesis of angiogenesis in cyanotic CHD...
  61. ncbi The hypoxia-inducible factor HIF-1 promotes intramyocardial expression of VEGF in infants with congenital cardiac defects
    Ma Qing
    Dept of Pediatric Cardiology, Aachen University Hospital, Pauwelsstrasse 30, 52074, Aachen, Germany
    Basic Res Cardiol 102:224-32. 2007
    ..This study was designed to test the hypothesis that HIF-1 and its target genes would be upregulated in the ventricular myocardium of infants with cyanotic congenital cardiac defects...
  62. ncbi Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: a novel pathophysiological adaptive mechanism
    C R Ferreiro
    Atherosclerosis Unit, Heart Institute, Department of Pharmacology, Institute of Biomedical Sciences, , Brazil
    Circulation 103:2272-6. 2001
    ..Therefore, a novel adaptive mechanism during hypoxia is suggested...
  63. ncbi Is end-tidal CO2 an accurate measure of arterial CO2 during laparoscopic procedures in children and neonates with cyanotic congenital heart disease?
    M L Wulkan
    Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA
    J Pediatr Surg 36:1234-6. 2001
    ..There are no data on the ability of capnography to predict arterial carbon dioxide concentrations (PaCO2) in patients with CCHD during pneumoperitoneum...
  64. ncbi Early detection of Berry syndrome in a newborn with differential cyanosis
    Nai chung Fong
    Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong, China
    Chin Med J (Engl) 119:1485-8. 2006
  65. ncbi Amplatzer vascular plug closure of a Blalock-Taussig shunt through a Glenn shunt
    S Ramakrishnan
    Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
    Catheter Cardiovasc Interv 72:413-5. 2008
    ..The BT shunt which was clipped during the surgery was found to be patent. The BT shunt was finally closed from the bidirectional Glenn using an Amplatzer vascular plug, resulting in symptom relief...
  66. ncbi Serum vascular endothelial growth factor in cyanotic congenital heart disease functionally contributes to endothelial cell kinetics in vitro
    Hiromichi Hamada
    Department of Pediatrics, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
    Int J Cardiol 120:66-71. 2007
    ..develop in patients with cyanotic congenital heart disease who have low pulmonary blood flow and systemic cyanosis, but the factors functionally responsible for angiogenesis in cyanotic congenital heart disease have not been ..
  67. ncbi Overproduction of platelet microparticles in cyanotic congenital heart disease with polycythemia
    Hitoshi Horigome
    Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    J Am Coll Cardiol 39:1072-7. 2002
    ....
  68. ncbi Predictive factors for long-term prognosis in adults with cyanotic congenital heart disease--Japanese multi-center study
    Hisanori Sakazaki
    Department of Pediatric Cardiology in the Heart Center, Amagasaki Hospital, 1 1 1 Higashidaimotsu, Amagasaki, Hyogo 660 0828, Japan
    Int J Cardiol 120:72-8. 2007
    ..We aimed to identify predictive factors related to long-term prognosis through a Japanese multi-center cross-sectional study...
  69. ncbi Brain abscess in children
    Mehnaz Atiq
    Department of Paediatrics, The Aga Khan University Hospital, Karachi, Pakistan
    Indian J Pediatr 73:401-4. 2006
    ..The objective of this study was to look at the clinical profile of patients, predisposing conditions, microbiology and outcome of children suffering from brain abscess...
  70. ncbi Increased angiogenic growth factor in cyanotic congenital heart disease
    W Himeno
    Department of Pediatrics, Kurume University, 67 Asahi Machi, Kurume, Japan 830 0011
    Pediatr Cardiol 24:127-32. 2003
    To examine the relationship between the plasma levels of angiogenic growth factors and the severity of cyanosis, 80 patients with cyanotic heart disease (CHD) and 81 healthy controls were studied...
  71. ncbi Right superior vena cava draining in the left atrium: anatomical, embryological, and surgical considerations
    Guido Oppido
    Pediatric Cardiac Surgery Unit, S Orsola Malpighi Hospital, University of Bologna Medical School, Bologna, Italy
    Ann Thorac Surg 81:2313-5. 2006
    ..This rare cyanotic, congenital, cardiac malformation is herein described with particular regard to its anatomical, embryological, and surgical implications...
  72. ncbi Does normoxemic cardiopulmonary bypass prevent myocardial reoxygenation injury in cyanotic children?
    Füsun S Bulutcu
    Departments of Anesthesiology and Reanimation, Cardiothoracic and Vascular Surgery, and Pediatric Cardiology, Kadir Has University, Florence Nightingale Hospital, Istanbul, Turkey
    J Cardiothorac Vasc Anesth 16:330-3. 2002
    ..To evaluate whether the deleterious effect of cardiopulmonary bypass (CPB) can be prevented by controlling PaO(2) in cyanotic children...
  73. ncbi Breath-holding spells associated with significant bradycardia: successful treatment with permanent pacemaker implantation
    A M Kelly
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Pediatrics 108:698-702. 2001
    ..CONCLUSIONS: Permanent pacemaker therapy for children with pallid breath-holding spells associated with severe bradycardia is safe, efficacious, and warranted...
  74. ncbi Panayiotopoulos syndrome: a benign childhood autonomic epilepsy frequently imitating encephalitis, syncope, migraine, sleep disorder, or gastroenteritis
    Athanasios Covanis
    Neurology Department, Agia Sophia Children s Hospital, Thivon and Levadias, Goudi, 11527 Athens, Greece
    Pediatrics 118:e1237-43. 2006
    ..It is characterized by seizures, often prolonged, with predominantly autonomic symptoms, and by an EEG [electroencephalogram] that shows shifting and/or multiple foci, often with occipital predominance."..
  75. ncbi Pernio in pediatrics
    Tamara D Simon
    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Pediatrics 116:e472-5. 2005
    ..diagnosis alternative would be Raynaud's phenomenon, which consists of sharply demarcated cutaneous pallor and cyanosis, followed by erythema, of far shorter duration (hours rather than days)...
  76. ncbi [Congenital heart disease and acquired valvular lesions in pregnancy]
    Dieter Horstkotte
    Kardiologische Klinik, Herzzentrum Nodrhein Westfalen, Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Herz 28:227-39. 2003
    ..As a consequence of the decrease of systemic vascular resistance, the systolic and, even more, the diastolic blood pressures are reduced during approximately the first 20 weeks of pregnancy...
  77. ncbi Impact of telemedicine on the practice of pediatric cardiology in community hospitals
    Craig A Sable
    Children s National Medical Center and George Washington University Medical School, Washington, DC, USA
    Pediatrics 109:E3. 2002
    ....
  78. ncbi Raynaud's phenomenon of the nipple: a treatable cause of painful breastfeeding
    Jane E Anderson
    Department of Pediatrics, University of California, San Francisco, California 94115, USA
    Pediatrics 113:e360-4. 2004
    ..with symptoms precipitated by cold temperatures and associated with blanching of the nipple followed by cyanosis and/or erythema...
  79. pmc Glucose-6-phosphatase deficiency
    Roseline Froissart
    Centre de Référence Maladies Héréditaires du Métabolisme Hépatique, Service de Pediatrie, APHP, Clamart Cedex, France
    Orphanet J Rare Dis 6:27. 2011
    ..The disease commonly manifests, between the ages of 3 to 4 months by symptoms of hypoglycemia (tremors, seizures, cyanosis, apnea)...
  80. ncbi Congenital para esophageal hernia: a 10 year experience from Saudi Arabia
    Nishith Kumar Jetley
    Department of Pediatric Surgery, Assir Central Hospital, Abha, KSA, Saudi Arabia
    Indian J Pediatr 76:489-93. 2009
    ..The authors sought to study the presentation and the outcome of treatment of congenital para esophageal hernias (CPEH) over a period of 10 years from a single tertiary care hospital in Saudi Arabia...
  81. ncbi Retropharyngeal aberrant thymus
    S S Shah
    Division of General Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 108:E94. 2001
    ..We present the case of an infant with respiratory distress attributed to aberrant thymic tissue located in the retropharyngeal space...
  82. ncbi [Neonatal Volkmann's syndrome]
    M Dandurand
    Service de Dermatologie, Hopital Caremeau, CHU de Nimes, place du professeur R Debré, 30029 Nimes Cedex 9, France
    Ann Dermatol Venereol 136:785-9. 2009
    ..Acute limb compartment syndrome or Volkmann's ischaemic contracture is an acquired ischaemia of nerve and muscle causes by raised pressure within a closed fascial space. Congenital Volkmann's ischaemic contracture (CVIC) is a rare entity...
  83. ncbi Two cases of methemoglobinemia following zopiclone ingestion
    Hin Tat Fung
    Tuen Mun Hospital, Hong Kong, China
    Clin Toxicol (Phila) 46:167-70. 2008
    ..Intoxication with zopiclone is expected to produce drowsiness, confusion and coma but not methemoglobinemia. We report two cases of zopiclone overdose with methemoglobinemia...
  84. ncbi Ebstein's malformation. surgical treatment and results
    S Chauvaud
    Department of Cardiac Surgery, Hopital Broussais, Paris, France
    Thorac Cardiovasc Surg 48:220-3. 2000
    ..From January 1980 to December 1999, 142 patients underwent surgery. The mean age was 25 +/- 15 years (1-65). Cyanosis was present in 48% and associated lesions in 64% of the patients...
  85. ncbi Pharmacodynamic effects of serotonin (5-HT) receptor ligands in pigs: stimulation of 5-HT2 receptors induces malignant hyperthermia
    W Loscher
    Department of Pharmacology, School of Veterinary Medicine, Hannover, Federal Republic of Germany
    Naunyn Schmiedebergs Arch Pharmacol 341:483-93. 1990
    ..skeletal muscle rigidity, leading to an increase in body temperature, marked acidosis, hyperkaliaemia, cyanosis and elevation of lactate, carbon dioxide and the muscle enzyme creatine kinase (CK) in plasma...
  86. ncbi Mimics of Ebstein's anomaly
    N M Ammash
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester 55905, USA
    Am Heart J 134:508-13. 1997
    ..Two patients had cyanosis. Three patients had paroxysmal and six had chronic atrial fibrillation/flutter...
  87. ncbi Inhalation toxicity of 4-ethoxyaniline (p-phenetidine): critical analysis of results of subacute inhalation exposure studies in rats
    J Pauluhn
    Institute of Toxicology, Bayer AG, Building No 514, 42096 Wuppertal, Germany
    Inhal Toxicol 13:993-1013. 2001
    ..Rats exposed to 882.6 mg/m(3) and above evoked characteristic signs of toxicity that included cyanosis, with no apparent progression of findings during the exposure period. Animals exposed to 86...
  88. ncbi [Superior vena cava thrombosis after in vitro fertilization]
    J Brechmann
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen
    Dtsch Med Wochenschr 125:1429-32. 2000
    ..Clinical findings showed a soft and slightly painful swelling of the right side of the neck without dyspnoea or cyanosis at rest. Breath sounds were decreased over the right lower lung on auscultation.
  89. ncbi Subacute inhalation toxicity of aniline in rats: analysis of time-dependence and concentration-dependence of hematotoxic and splenic effects
    Jürgen Pauluhn
    Institute of Toxicology, Bayer HealthCare AG, D 42096 Wuppertal, Germany
    Toxicol Sci 81:198-215. 2004
    ..No mortality was observed during the study. Rats exposed to 96.5 mg/m3 and above displayed cyanosis, with no apparent progression during the exposure period...
  90. ncbi Peroneal nerve palsy: a complication of umbilical artery catheterization in the full-term newborn of a mother with diabetes
    Christina Giannakopoulou
    Department of Neonatology, University of Crete, Crete, Greece
    Pediatrics 109:e66. 2002
    ..The most frequent visible problem in an umbilical line is blanching or cyanosis of part or all of a distal extremity or the buttock area resulting from either vasospasm or a thrombotic or ..
  91. ncbi Out-of-hospital treatment of opioid overdoses in an urban setting
    K A Sporer
    Department of Emergency Services, University of California, Los Angeles, School of Medicine, USA
    Acad Emerg Med 3:660-7. 1996
    ..To investigate clinical outcomes in a cohort of opioid overdose patients treated in an out-of-hospital urban setting noted for a high prevalence of i.v. opioid use...
  92. ncbi Conditions leading to pediatric cardiology consultation in a tertiary academic hospital
    Robert L Geggel
    Department of Cardiology, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 114:e409-17. 2004
    ..To determine the basis for cardiac consultations for pediatric patients in an academic hospital setting...
  93. ncbi Current surgical therapy for Ebstein anomaly in neonates
    Brian L Reemtsen
    Children s Hospital Los Angeles and the Keck School of Medicine, Los Angeles, Calif 90027, USA
    J Thorac Cardiovasc Surg 132:1285-90. 2006
    ..Neonates with profound heart failure resulting from Ebstein anomaly have historically had poor outcomes. We report our institutional experience with the surgical management of Ebstein anomaly in severely symptomatic neonates...
  94. pmc Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes
    P H Weinstock
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York 10021, USA
    J Clin Invest 96:2555-68. 1995
    ..chylomicrons prevent red cell contact with the endothelium, a phenomenon which is presumably the cause of cyanosis and death in these mice...
  95. ncbi Subacute inhalation toxicity of 2-chloro-4-toluidine in rats
    Jürgen Pauluhn
    Institute of Toxicology, Bayer HealthCare AG, Wuppertal, Germany
    Inhal Toxicol 18:1117-34. 2006
    ..Rats exposed for 4 wk to 702.3 mg/m3 displayed characteristic signs of toxicity that included cyanosis, respiratory distress, and significantly decreased body weights...
  96. ncbi Occupational methaemoglobinaemia. Mechanisms of production, features, diagnosis and management including the use of methylene blue
    Sally M Bradberry
    National Poisons Information Service Birmingham Centre, City Hospital, Birmingham, UK
    Toxicol Rev 22:13-27. 2003
    ..observations may help: firstly, the victim is often less unwell than one would expect from the severity of 'cyanosis' and, secondly, the 'cyanosis' is unresponsive to oxygen therapy...
  97. ncbi Is acid gastroesophageal reflux in children with ALTE etiopathogenetic factor of life threatening symptoms?
    J Semeniuk
    III Department of Pediatrics, Medical University of Białystok, Ul Waszyngtona 17, 15 274 Białystok, Poland
    Adv Med Sci 52:213-21. 2007
    ..Among these symptoms are apnea, cyanosis, pallor, hypotonia, non-epileptic seizures, consciousness disorders and bradycardia.
  98. ncbi Efficacy of granisetron in preventing postanesthetic shivering
    Parvin Sajedi
    Department of Anesthesia and Critical Care, Isfahan University of Medical Sciences, Isfahan, Iran
    Acta Anaesthesiol Taiwan 46:166-70. 2008
    ..This placebo-controlled study was performed to evaluate the efficacy of granisetron, a 5-HT3 antagonist, in comparison with meperidine and tramadol in preventing postanesthetic shivering...
  99. ncbi [Prognostic value of right ventricular dysfunction and derivation of a prognostic model for patients with acute pulmonary thromboembolism]
    Ling Zhu
    Beijing Institute of Respiratory Medicine, Beijing Chao Yang Hospital, Capital Medical University, Beijingt 100020, China
    Zhonghua Liu Xing Bing Xue Za Zhi 30:184-8. 2009
    ..RVD was assessed in prognosis to which a model on it was constructed to decide the indexes correlated to the best prognosis...
  100. pmc Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    BMC Clin Pharmacol 9:3. 2009
    ..However, there is limited information about the clinical toxicity and kinetics. The objective of this study is to describe the clinical outcomes and kinetics of propanil following acute intentional self-poisoning...
  101. ncbi Pneumocystis carinii pneumonia in South African children infected with human immunodeficiency virus
    H J Zar
    Department of Paediatrics and Child Health, Red Cross War Memorial Children s Hospital, University of Cape Town, South Africa
    Pediatr Infect Dis J 19:603-7. 2000
    ..There is little information on the incidence of PCP in HIV-infected children in Africa...

Research Grants11

  1. CYTOCHROME B5--A CASE STUDY IN MOLECULAR RECOGNITION
    Mario Rivera; Fiscal Year: 1999
    ..this pathway predisposes the organism to methemoglobinemia, a pathological condition which can cause systems from cyanosis to mental retardation...
  2. STRUCTURE AND ROLE(S) OF GASTRIC AND THYMIC PEPTIDES
    Robert Carraway; Fiscal Year: 1980
    ..When injected intravenously NT induces hypotension, increased vascular permeability, hyperglycemia, and cyanosis in the anesthetized rat and also has been found to affect the secretion of pituitary and pancreatic hormones...
  3. MODULATION OF BREATHING BY UPPER AIRWAY CHEMORECEPTORS
    DAVID DONNELLY; Fiscal Year: 1991
    ..g. coughing, swallowing) are impaired or immature leaving the threat of protracted apnea and cyanosis. Despite the potential importance of this reflex, little is known of the central pathway over which this reflex ..
  4. MECHANISM OF REACTIONS OF HEMOGLOBIN WITH LIGANDS
    Vijay Sharma; Fiscal Year: 1991
    ..in aberrations of the functional behavior and pathological conditions such as sickle cell anemia, hemolysis and cyanosis among others...
  5. CASPASE INHIBITION OF APOPTOSIS, INFANT CARDIAC SURGERY
    FRANCIS MCGOWAN; Fiscal Year: 2005
    ..multifactorial, evidence suggests that it in large part may be due to myocyte loss resulting from chronic cyanosis, prolonged exposure to abnormal hemodynamic loads, and one or more episodes of ischemia-reperfusion required for ..
  6. Multidisciplinary Study of Right Ventricular Dysplasia
    Jeffrey Towbin; Fiscal Year: 2005
    ..This integrated research grant proposal offers a substantial prospect of expanding the fund of clinical knowledge regarding ARVD and of localizing the gene(s) responsible for this disorder. ..
  7. Role of Obscurin and Obscurin-MLCK in myofibrillogenesis
    Mark Russell; Fiscal Year: 2008
    ..Characterizing obscurin's roles in new myofibril assembly and in sarcomere-sarcoplasma organization may identify new strategies to treat congestive heart failure and prevent myofibril damage during ischemia. ..
  8. CLONING OF A POTENTIAL REGULATOR OF THE DHAND FACTOR
    Mark Russell; Fiscal Year: 2002
    ....
  9. Mentored Patient-Oriented Research Career Development Award
    Ruey Kang Chang; Fiscal Year: 2006
    ..The principal investigator will take advanced courses to enhance knowledge and skills needed for patient-oriented research and work with the mentors to conduct the proposed project during the award period. ..
  10. Detecting Endothelial Dysfunction in Renal Failure
    Julian Stewart; Fiscal Year: 2007
    ..These data will form the basis of future noninvasive prognostic testing and treatment of patients at risk for ECD and can provide a means to follow treatment modalities. [unreadable] [unreadable] [unreadable]..
  11. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ....