fever

Summary

Summary: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Top Publications

  1. pmc Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in Uganda
    Daniel J Kyabayinze
    Malaria Consortium Africa, Plot 2, Sturrock Road, PO Box 8045, Kampala, Uganda
    Malar J 9:200. 2010
  2. pmc Fever with thrombocytopenia associated with a novel bunyavirus in China
    XUE JIE YU
    Chinese Center for Disease Control and Prevention, Beijing, China
    N Engl J Med 364:1523-32. 2011
  3. doi Antimicrobial prophylaxis and outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology clinical practice guideline
    Christopher R Flowers
    Emory University School of Medicine, Atlanta, GA, USA
    J Clin Oncol 31:794-810. 2013
  4. ncbi Rift Valley fever epidemic in Saudi Arabia: epidemiological, clinical, and laboratory characteristics
    Tariq A Madani
    Ministry of Health, Riyadh, Saudi
    Clin Infect Dis 37:1084-92. 2003
  5. pmc Influence of rapid malaria diagnostic tests on treatment and health outcome in fever patients, Zanzibar: a crossover validation study
    Mwinyi I Msellem
    Malaria Control Programme, Ministry of Health and Social Welfare, Zanzibar, Tanzania
    PLoS Med 6:e1000070. 2009
  6. doi Beyond malaria--causes of fever in outpatient Tanzanian children
    Valérie D'Acremont
    From the Swiss Tropical and Public Health Institute and University of Basel, Basel V D, J K M, C L, B G, the Department of Ambulatory Care and Community Medicine, University of Lausanne V D, B G, and the Infectious Diseases Service, University Hospital B G, Lausanne, and the Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospital of Geneva, and Faculty of Medicine, University of Geneva, Geneva P C, L K all in Switzerland the City Medical Office of Health, Dar es Salaam City Council V D, J K M, and Amana Hospital M K, W S, Dar es Salaam, Ifakara Health Institute, Dar es Salaam and Ifakara B G, and St Francis Hospital, Ifakara E K, S P all in Tanzania
    N Engl J Med 370:809-17. 2014
  7. doi Central circuitries for body temperature regulation and fever
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto Univ, School of Medicine Bldg E, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Am J Physiol Regul Integr Comp Physiol 301:R1207-28. 2011
  8. ncbi Heat stroke
    Abderrezak Bouchama
    Medical and Surgical Intensive Care Unit and Comparative Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    N Engl J Med 346:1978-88. 2002
  9. pmc Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus
    Bianli Xu
    Center for Disease Control and Prevention of Henan Province, Zhengzhou, China
    PLoS Pathog 7:e1002369. 2011
  10. ncbi 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline
    Thomas J Smith
    American Society of Clinical Oncology, Cancer Policy and Clinical Affairs, Alexandria, VA 22314, USA
    J Clin Oncol 24:3187-205. 2006

Research Grants

  1. Merrill D Benson; Fiscal Year: 2014
  2. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
  3. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
  4. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
  5. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
  6. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
  7. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
  8. Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2009
  9. Roy Curtiss Iii; Fiscal Year: 2016
  10. ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2016

Detail Information

Publications444 found, 100 shown here

  1. pmc Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in Uganda
    Daniel J Kyabayinze
    Malaria Consortium Africa, Plot 2, Sturrock Road, PO Box 8045, Kampala, Uganda
    Malar J 9:200. 2010
    ..This study evaluated the effect of malaria RDTs on health workers' anti-malarial drug (AMD) prescriptions among outpatients at low level health care facilities (LLHCF) within different malaria epidemiological settings in Uganda...
  2. pmc Fever with thrombocytopenia associated with a novel bunyavirus in China
    XUE JIE YU
    Chinese Center for Disease Control and Prevention, Beijing, China
    N Engl J Med 364:1523-32. 2011
    Heightened surveillance of acute febrile illness in China since 2009 has led to the identification of a severe fever with thrombocytopenia syndrome (SFTS) with an unknown cause...
  3. doi Antimicrobial prophylaxis and outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology clinical practice guideline
    Christopher R Flowers
    Emory University School of Medicine, Atlanta, GA, USA
    J Clin Oncol 31:794-810. 2013
    To provide guidelines on antimicrobial prophylaxis for adult neutropenic oncology outpatients and on selection and treatment as outpatients of those with fever and neutropenia.
  4. ncbi Rift Valley fever epidemic in Saudi Arabia: epidemiological, clinical, and laboratory characteristics
    Tariq A Madani
    Ministry of Health, Riyadh, Saudi
    Clin Infect Dis 37:1084-92. 2003
    ..descriptive study summarizes the epidemiological, clinical, and laboratory characteristics of the Rift Valley fever (RVF) epidemic that occurred in Saudi Arabia from 26 August 2000 through 22 September 2001...
  5. pmc Influence of rapid malaria diagnostic tests on treatment and health outcome in fever patients, Zanzibar: a crossover validation study
    Mwinyi I Msellem
    Malaria Control Programme, Ministry of Health and Social Welfare, Zanzibar, Tanzania
    PLoS Med 6:e1000070. 2009
    ..Our objective was to study the influence of RDT-aided malaria diagnosis on drug prescriptions, health outcomes, and costs in primary health care settings...
  6. doi Beyond malaria--causes of fever in outpatient Tanzanian children
    Valérie D'Acremont
    From the Swiss Tropical and Public Health Institute and University of Basel, Basel V D, J K M, C L, B G, the Department of Ambulatory Care and Community Medicine, University of Lausanne V D, B G, and the Infectious Diseases Service, University Hospital B G, Lausanne, and the Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospital of Geneva, and Faculty of Medicine, University of Geneva, Geneva P C, L K all in Switzerland the City Medical Office of Health, Dar es Salaam City Council V D, J K M, and Amana Hospital M K, W S, Dar es Salaam, Ifakara Health Institute, Dar es Salaam and Ifakara B G, and St Francis Hospital, Ifakara E K, S P all in Tanzania
    N Engl J Med 370:809-17. 2014
    As the incidence of malaria diminishes, a better understanding of nonmalarial fever is important for effective management of illness in children. In this study, we explored the spectrum of causes of fever in African children.
  7. doi Central circuitries for body temperature regulation and fever
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto Univ, School of Medicine Bldg E, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Am J Physiol Regul Integr Comp Physiol 301:R1207-28. 2011
    ..also functions for host defense from invading pathogens by elevating body core temperature, a response known as fever. Thermoregulation and fever involve a variety of involuntary effector responses, and this review summarizes the ..
  8. ncbi Heat stroke
    Abderrezak Bouchama
    Medical and Surgical Intensive Care Unit and Comparative Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    N Engl J Med 346:1978-88. 2002
  9. pmc Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus
    Bianli Xu
    Center for Disease Control and Prevention of Henan Province, Zhengzhou, China
    PLoS Pathog 7:e1002369. 2011
    Since 2007, many cases of fever, thrombocytopenia and leukopenia syndrome (FTLS) have emerged in Henan Province, China. Patient reports of tick bites suggested that infection could contribute to FTLS...
  10. ncbi 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline
    Thomas J Smith
    American Society of Clinical Oncology, Cancer Policy and Clinical Affairs, Alexandria, VA 22314, USA
    J Clin Oncol 24:3187-205. 2006
    ..Guided by the 1996 ASCO clinical outcomes criteria, the Update Committee formulated recommendations based on improvements in survival, quality of life, toxicity reduction and cost-effectiveness...
  11. pmc Arthropod borne disease: the leading cause of fever in pregnancy on the Thai-Burmese border
    Rose McGready
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    PLoS Negl Trop Dis 4:e888. 2010
    b>Fever in pregnancy is dangerous for both mother and foetus. In the 1980's malaria was the leading cause of death in pregnant women in refugee camps on the Thai-Burmese border...
  12. ncbi Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Pediatrics 114:1708-33. 2004
    Kawasaki disease is an acute self-limited vasculitis of childhood that is characterized by fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy...
  13. pmc Malaria misdiagnosis in Uganda--implications for policy change
    Joan Nankabirwa
    Malaria Consortium, Africa Regional Office, Kampala, Uganda
    Malar J 8:66. 2009
    ..In this study, the policy implications of such recommendations are revisited...
  14. doi Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic test
    Valérie D'Acremont
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Clin Infect Dis 51:506-11. 2010
    ..The objective of the present study was to evaluate the safety of withholding antimalarials in febrile children who have a negative test result...
  15. doi Basic clinical and laboratory features of filoviral hemorrhagic fever
    Mark G Kortepeter
    Department of Preventive Medicine, Infectious Disease Clinical Research Program, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814 5119, USA
    J Infect Dis 204:S810-6. 2011
    The filoviruses Marburg and Ebola cause severe hemorrhagic fever (HF) in humans. Beginning with the 1967 Marburg outbreak, 30 epidemics, isolated cases, and accidental laboratory infections have been described in the medical literature...
  16. doi Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review
    Ann Van den Bruel
    Department of Primary Health Care, University of Oxford, UK
    BMJ 342:d3082. 2011
    ..To collate all available evidence on the diagnostic value of laboratory tests for the diagnosis of serious infections in febrile children in ambulatory settings...
  17. pmc Feasibility and acceptability of artemisinin-based combination therapy for the home management of malaria in four African sites
    IkeOluwapo O Ajayi
    Malaria Research Laboratories, Institute of Medical Research and Training, College of Medicine, University of Ibadan, Nigeria
    Malar J 7:6. 2008
    ..The feasibility and acceptability of incorporating ACT in HMM needs to be evaluated...
  18. doi Rapid malaria diagnostic tests vs. clinical management of malaria in rural Burkina Faso: safety and effect on clinical decisions. A randomized trial
    Zeno Bisoffi
    Centre for Tropical Diseases, Sacro Cuore Hospital, Negrar Verona, Italy
    Trop Med Int Health 14:491-8. 2009
    ....
  19. pmc Humanized mice show clinical signs of dengue fever according to infecting virus genotype
    Javier Mota
    Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    J Virol 83:8638-45. 2009
    ..the four genotypes) of dengue virus serotype 2 (DEN-2) can induce the development of human-like disease, including fever, viremia, erythema, and thrombocytopenia...
  20. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
    ..hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF)...
  21. pmc Feasibility and acceptability of home-based management of malaria strategy adapted to Sudan's conditions using artemisinin-based combination therapy and rapid diagnostic test
    Khalid A Elmardi
    National Malaria Control Programme, Federal Ministry of Health, Khartoum, Sudan
    Malar J 8:39. 2009
    ..This research aimed to assess the feasibility and acceptability of home-based management of malaria (HMM) strategy using artemisinin-based combination therapy (ACT) for treatment and rapid diagnostic test (RDT) for diagnosis...
  22. pmc Evolutionary and molecular analysis of the emergent severe fever with thrombocytopenia syndrome virus
    Tommy Tsan Yuk Lam
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Epidemics 5:1-10. 2013
    In 2009, a novel Bunyavirus, called severe fever with thrombocytopenia syndrome virus (SFTSV) was identified in the vicinity of Huaiyangshan, China...
  23. pmc Dengue incidence in urban and rural Cambodia: results from population-based active fever surveillance, 2006-2008
    Sirenda Vong
    Institut Pasteur Cambodia, Phnom Penh, Cambodia
    PLoS Negl Trop Dis 4:e903. 2010
    ..To estimate the true burden of dengue in the largest province of Cambodia, Kampong Cham, we conducted community-based active dengue fever surveillance among the 0-to-19-year age group in rural villages and urban areas during 2006-2008.
  24. ncbi Sporadic case infected by severe fever with thrombocytopenia syndrome bunyavirus in a non-epidemic region of China
    Shibo Li
    Department of Infectious Diseases, Zhoushan Hospital, Zhejiang, China
    Biosci Trends 5:273-6. 2011
    We report here a clinical and molecular study on a case suffer from severe fever with thrombocytopenia syndrome (SFTS) due to a new type of bunyavirus, named SFTS bunyavirus (SFTSV), in Zhejiang Province China...
  25. doi P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release
    Maria Barberà-Cremades
    Inflammation and Experimental Surgery Unit, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University Hospital Virgen de Arrixaca Fundación Formación Investigación Sanitaria Región Murcia, Murcia, Spain
    FASEB J 26:2951-62. 2012
    Prostaglandins (PGs) are important lipid mediators involved in the development of inflammatory associated pain and fever. PGE2 is a well-established endogenous pyrogen activated by proinflammatory cytokine interleukin (IL)-1β...
  26. pmc Parental and medical knowledge and management of fever in Italian pre-school children
    Elena Chiappini
    Department of Sciences for Woman and Child s Health, University of Florence, Florence, Italy
    BMC Pediatr 12:97. 2012
    Guidelines for the management of fever in children have been recently published, however "fever phobia" is still spreading...
  27. doi Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in dengue hemorrhagic fever
    Punnee Butthep
    Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Pediatr Infect Dis J 31:e232-8. 2012
    ..The study was designed to demonstrate the alteration of cytokines and chemokines in dengue-infected patients during febrile episodes...
  28. ncbi Timing for fever-related brain damage in acute ischemic stroke
    J Castillo
    Department of Neurology, Complexo Hospitalario Universitario de Santiago Hospital Xeral de Galicia, Barcelona, Spain
    Stroke 29:2455-60. 1998
    ..The aim of this study was to determine the prognostic value of body temperature measured at different times after onset of stroke...
  29. ncbi Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Endotoxin Res 10:201-22. 2004
    For many years, it was thought that bacterial products caused fever via the intermediate production of a host-derived, fever-producing molecule, called endogenous pyrogen (EP)...
  30. doi The role of procalcitonin in febrile neutropenic patients: review of the literature
    Y Sakr
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee 103, Jena, Germany
    Infection 36:396-407. 2008
    ..evaluate the role of PCT measurements in febrile neutropenic patients in differentiating between various causes of fever and to investigate the value of PCT levels in terms of diagnosing infection or predicting outcome in these patients...
  31. pmc Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania
    Julian T Hertz
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Trop Med Hyg 86:171-7. 2012
    ..5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating...
  32. pmc Use of over-the-counter malaria medicines in children and adults in three districts in Kenya: implications for private medicine retailer interventions
    Timothy O Abuya
    Kenya Medical Research Institute Wellcome Trust Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Malar J 6:57. 2007
    ..as important targets to promote effective early treatment, based on reported widespread inadequate childhood fever treatment practices involving the retail sector. Data on adult use of over-the-counter (OTC) medicines is limited...
  33. doi Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme
    Richard Beasley
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Lancet 372:1039-48. 2008
    ..We studied 6-7-year-old children from Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) programme to investigate the association between paracetamol consumption and asthma...
  34. pmc A country-wide malaria survey in Mozambique. II. Malaria attributable proportion of fever and establishment of malaria case definition in children across different epidemiological settings
    Samuel Mabunda
    National Malaria Control Programme, Maputo, Mozambique
    Malar J 8:74. 2009
    ..In many settings of stable malaria transmission, the presence of asymptomatic malaria parasite carriers is common and the definition of clinical malaria remains uncertain...
  35. ncbi Role of fever in disease
    M J Kluger
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
    Ann N Y Acad Sci 856:224-33. 1998
    ..result in a stereotypical response that includes loss of food appetite, increased sleepiness, muscle aches, and fever. For thousands of years fever was considered a protective response, and fevers were induced by physicians to ..
  36. doi Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America
    NAOMI P O'GRADY
    National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 36:1330-49. 2008
    To update the practice parameters for the evaluation of adult patients who develop a new fever in the intensive care unit, for the purpose of guiding clinical practice.
  37. ncbi Quality of treatment for febrile illness among children at outpatient facilities in sub-Saharan Africa
    D Zurovac
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, Kenya Medical Research Institute Wellcome Trust Research Laboratories, P O Box 43640, 00100 GPO, Nairobi, Kenya
    Ann Trop Med Parasitol 100:283-96. 2006
    ..Some interventions, such as IMCI, can improve the treatment of not only malaria but also other potentially life-threatening illnesses...
  38. pmc Fever and the heat shock response: distinct, partially overlapping processes
    J D Hasday
    Department of Medicine, University of Maryland School of Medicine and the Medicine and Research Services of the Baltimore VA Medical Center, 21201, USA
    Cell Stress Chaperones 5:471-80. 2000
    ..b>Fever is a more recently evolved response, during which organisms temporarily subject themselves to thermal stress in ..
  39. ncbi Fever phobia revisited: have parental misconceptions about fever changed in 20 years?
    M Crocetti
    Department of Pediatrics, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Pediatrics 107:1241-6. 2001
    b>Fever is one of the most common reasons that parents seek medical attention for their children. Parental concerns arise in part because of the belief that fever is a disease rather than a symptom or sign of illness...
  40. ncbi The role of fever in the infected host
    J D Hasday
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, and the Medicine Services of the Baltimore Veterans Affairs Centre, MD 21201, USA
    Microbes Infect 2:1891-904. 2000
    Sepsis is a highly lethal clinical syndrome characterized by a systemic inflammatory response to infection. Fever, a non-specific acute-phase response, has been associated with improved survival and shortened disease duration in non-life-..
  41. ncbi Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults
    N French
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    AIDS 15:899-906. 2001
    ..OBJECTIVE: To investigate the effect of HIV-associated immunosuppression on malarial fever rates...
  42. pmc Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis
    Mical Paul
    Rabin Medical Centre, Beilinson Campus, Infectious Diseases Unit and Department of Medicine E, Petah Tiqva 49100, Israel
    BMJ 326:1111. 2003
    To compare the effectiveness of beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy in the treatment of patients with fever and neutropenia.
  43. pmc The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses
    Jonathan C Craig
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, Australia
    BMJ 340:c1594. 2010
    ..Design Two year prospective cohort study. Setting The emergency department of The Children's Hospital at Westmead, Westmead, Australia...
  44. pmc Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in northern Tanzania
    Malavika Prabhu
    Department of Medicine, Division of Infectious Diseases and International Health, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA
    Clin Infect Dis 53:e8-15. 2011
    The importance of Q fever, spotted fever group rickettsiosis (SFGR), and typhus group rickettsiosis (TGR) as causes of febrile illness in sub-Saharan Africa is unknown; the putative role of Q fever as a human immunodeficiency virus (HIV) ..
  45. doi Fever control using external cooling in septic shock: a randomized controlled trial
    Frederique Schortgen
    Service de Reanimation Medicale, CHU Henri Mondor, 94000 Creteil, France
    Am J Respir Crit Care Med 185:1088-95. 2012
    b>Fever control may improve vascular tone and decrease oxygen consumption, but fever may contribute to combat infection.
  46. pmc Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model
    Cong Jin
    Laboratory of Viral Hemorrhagic Fever, National Institute for Viral Disease Control and Prevention, China Center for Disease Control Beijing 102206, China
    Proc Natl Acad Sci U S A 109:10053-8. 2012
    The discovery of an emerging viral disease, severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), has prompted the need to understand pathogenesis of SFTSV...
  47. pmc Chikungunya fever: a clinical and virological investigation of outpatients on Reunion Island, South-West Indian Ocean
    Simon Djamel Thiberville
    UMR 190, Emergence des Pathologies Virales, Aix Marseille Univ IRD EHESP French School of Public Health, University Hospital Institute for Infectious Disease and Tropical Medicine, Marseille, France
    PLoS Negl Trop Dis 7:e2004. 2013
    ..Although almost all patients are outpatients, medical investigations mainly focused on hospitalised patients...
  48. pmc Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trial
    Kojo Yeboah-Antwi
    Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000340. 2010
    ..This study was designed to assess the effectiveness and feasibility of using CHWs to manage nonsevere pneumonia and uncomplicated malaria with the aid of rapid diagnostic tests (RDTs)...
  49. doi Prediction of pneumonia in a pediatric emergency department
    Mark I Neuman
    Division of Emergency Medicine, 300 Longwood Ave, Boston, MA 02115
    Pediatrics 128:246-53. 2011
    ....
  50. pmc Etiology of acute, non-malaria, febrile illnesses in Jayapura, northeastern Papua, Indonesia
    Narain H Punjabi
    U S Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Trop Med Hyg 86:46-51. 2012
    We conducted a prospective, inpatient fever study in malaria-endemic Papua, Indonesia to determine non-malaria fever etiologies...
  51. doi Update of the 2009 Italian Pediatric Society Guidelines about management of fever in children
    Elena Chiappini
    Department of Sciences for Woman and Child s Health, University of Florence, Anna Meyer Children s University Hospital, Viale Pieraccini 24, Florence, Italy
    Clin Ther 34:1648-1653.e3. 2012
    In 2009, the Italian Pediatric Society developed national guidelines for management of fever in children for health care providers and parents/caregivers; an update of these guidelines was scheduled after 2 years.
  52. pmc Single cell transcriptomics of hypothalamic warm sensitive neurons that control core body temperature and fever response Signaling asymmetry and an extension of chemical neuroanatomy
    James Eberwine
    Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States
    Pharmacol Ther 129:241-59. 2011
    ..Our study suggests that it is well-worth interrogating the cDNA libraries of single neurons by sequencing and chipping...
  53. ncbi Influences on parents' fever management: beliefs, experiences and information sources
    Anne Walsh
    School of Nursing, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
    J Clin Nurs 16:2331-40. 2007
    To identify parents' knowledge, beliefs, management and sources of information about fever management.
  54. pmc An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurol 258:302-7. 2011
    Subfebrile temperature or fever is present in about a third of patients on the first day after stroke onset and is associated with poor outcome. However, the temporal profile of this association is not well established...
  55. doi Induced hypothermia and fever control for prevention and treatment of neurological injuries
    Kees H Polderman
    Department of Intensive Care, University Medical Center Utrecht, Utrecht, Netherlands
    Lancet 371:1955-69. 2008
    ..This Review discusses the available evidence for use of controlled hypothermia, and also deals with fever control...
  56. doi Effect of hyperthermia on prognosis after acute ischemic stroke
    Monica Saini
    Division of Neurology, Department of Medicine, University of Alberta, AB, Canada
    Stroke 40:3051-9. 2009
    ..Clinical studies evaluating the effect of temperature on poststroke outcome have, however, been limited by small sample sizes. We sought to evaluate the effect of temperature and timing of hyperthermia on outcome after ischemic stroke...
  57. doi Health seeking behavior after fever onset in a malaria-endemic area of Malawi
    Ruben E Mujica Mota
    University of Liverpool Management School, Liverpool, United Kingdom
    Am J Trop Med Hyg 81:935-43. 2009
    ..Total out of pocket costs of fever episodes constitutes between 9% and 14% in young children and 18% in adults of their total available resources...
  58. doi Tropheryma whipplei bacteremia during fever in rural West Africa
    Florence Fenollar
    Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Universite de la Mediterranee, Faculte de Medecine, 1Marseille, France
    Clin Infect Dis 51:515-21. 2010
    ..We investigated the role of T. whipplei in febrile patients from rural Senegal who had a negative test result for malaria...
  59. pmc Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
    R Horai
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108, Japan
    J Exp Med 187:1463-75. 1998
    ..b>Fever development upon injection with turpentine was suppressed in IL-1beta as well as IL-1alpha/beta KO mice, but not ..
  60. pmc Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study
    Hugh Reyburn
    London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 329:1212. 2004
    ..To study the diagnosis and outcomes in people admitted to hospital with a diagnosis of severe malaria in areas with differing intensities of malaria transmission...
  61. doi Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials
    Roman Prymula
    Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 374:1339-50. 2009
    Although fever is part of the normal inflammatory process after immunisation, prophylactic antipyretic drugs are sometimes recommended to allay concerns of high fever and febrile convulsion...
  62. ncbi Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever
    Thomas J Walsh
    National Cancer Institute, Bethesda, MD 20892, USA
    N Engl J Med 346:225-34. 2002
    Patients with neutropenia and persistent fever are often treated empirically with amphotericin B or liposomal amphotericin B to prevent invasive fungal infections. Antifungal triazoles offer a potentially safer and effective alternative.
  63. ncbi Causes and empirical treatment of fever in HIV-infected adult outpatients, Abidjan, Côte d'Ivoire
    Xavier Anglaret
    INSERM U 330, Universite Victor Segalen Bordeaux, France
    AIDS 16:909-18. 2002
    In Abidjan, HIV prevalence has been estimated at 20% in outpatients attending community clinics. Documenting causes of fever in HIV-infected adult outpatients may help to improve care in these centres with limited facilities.
  64. ncbi Accuracy of malaria diagnosis by microscopy, rapid diagnostic test, and PCR methods and evidence of antimalarial overprescription in non-severe febrile patients in two Tanzanian hospitals
    Emanuele Nicastri
    Virology Laboratory, Epidemiology Department, National Institute for Infectious Diseases Lazzaro Spallanzani INMI, Via Portuense 292, 00149 Rome, Italy
    Am J Trop Med Hyg 80:712-7. 2009
    ..5% and 97.6%, respectively. Overprescription and underdiagnosis rates were 29.3% and 30.8%, respectively. On-field training, clinical management of febrile illness, and malaria microscopy in remote settings should be considered...
  65. ncbi Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules
    S S Evans
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Blood 97:2727-33. 2001
    b>Fever is associated with increased survival during acute infection, although its mechanism of action is largely unknown...
  66. pmc Emerging evidence indicates that physiologically relevant thermal stress regulates dendritic cell function
    Julie R Ostberg
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA
    Cancer Immunol Immunother 55:292-8. 2006
    Elevations in temperature that are associated with inflammation or fever have been linked to improved survival from infections, enhanced immunological functions, and increased control of tumor growth...
  67. ncbi Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study
    C Suttinont
    Department of Medicine, Maharat Nakhon Ratchasima Hospital, Amphur Mueng, Nakhon Ratchasima Province, 30000, Thailand
    Ann Trop Med Parasitol 100:363-70. 2006
    ..The 845 patients investigated, of whom 661 were male, had a median age of 38 years and a median duration of fever, on presentation, of 3.5 days. Most (76.5%) were agricultural workers and most (68...
  68. pmc Rural-urban differences in maternal responses to childhood fever in South East Nigeria
    Benjamin S C Uzochukwu
    Department of Community Medicine, College of Medicine, University of Nigeria, Enugu, Nigeria
    PLoS ONE 3:e1788. 2008
    ..of vulnerability perceived by mothers will affect their perception of the severity and threat of their child's fever and the patterns of health care use...
  69. pmc Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations
    James A Potts
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Trop Med Int Health 13:1328-40. 2008
    ..The objective of this systematic review was to identify clinical and laboratory features that differentiate dengue fever (DF) and/or dengue haemorrhagic fever (DHF) from other febrile illnesses (OFI) in dengue-endemic populations.
  70. ncbi Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
    Jane W Newburger
    Circulation 110:2747-71. 2004
    Kawasaki disease is an acute self-limited vasculitis of childhood that is characterized by fever, bilateral nonexudative conjunctivitis, erythema of the lips and oral mucosa, changes in the extremities, rash, and cervical lymphadenopathy...
  71. pmc Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial
    Hugh Reyburn
    Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WCIE 7HT
    BMJ 334:403. 2007
    ..To compare rapid diagnostic tests (RDTs) for malaria with routine microscopy in guiding treatment decisions for febrile patients...
  72. pmc Accuracy of a rapid diagnostic test on the diagnosis of malaria infection and of malaria-attributable fever during low and high transmission season in Burkina Faso
    Zeno Bisoffi
    Centre for Tropical Diseases, S, Cuore Hospital, 37024 Negrar, Verona, Italy
    Malar J 9:192. 2010
    ..Moreover, no formal attempt has been made to estimate RDTs accuracy on malaria-attributable fever. This study aims at estimating the accuracy of a RDT for the diagnosis of both malaria infection and malaria - ..
  73. pmc Person-to-person transmission of severe fever with thrombocytopenia syndrome bunyavirus through blood contact
    Zhongtao Gai
    Jinan Infectious Disease Hospital, Shandong University, Jinan
    Clin Infect Dis 54:249-52. 2012
    Severe fever with thrombocytopenia syndrome bunyavirus is a newly discovered bunyavirus with high pathogenicity to human. The transmission model has been largely uncharacterized...
  74. pmc Spatial modelling of healthcare utilisation for treatment of fever in Namibia
    Victor A Alegana
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, PO Box 43640, 00100 GPO Nairobi, Kenya
    Int J Health Geogr 11:6. 2012
    ..Here, empirical household survey data on treatment seeking for fever were used to model the utilisation of public health facilities and define their catchment areas and populations in ..
  75. doi Clinical features and molecular diagnosis of Chikungunya fever from South India
    Vemu Lakshmi
    Department of Microbiology, Nizam s Institute of Medical Sciences, Hyderabad, India
    Clin Infect Dis 46:1436-42. 2008
    An epidemic of Chikungunya fever of unprecedented magnitude occurred in many parts of India in early 2006 after an interval of 33 years, and there has been a resurgence in some parts of South India since June 2007...
  76. pmc Clinical and laboratory features that differentiate dengue from other febrile illnesses in an endemic area--Puerto Rico, 2007-2008
    Christopher J Gregory
    Epidemic Intelligence Service Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Am J Trop Med Hyg 82:922-9. 2010
    ..accuracy of the models was greater than either the current World Health Organization case definition for dengue fever or a proposed modification to this definition, while requiring the collection of fewer data...
  77. ncbi Combating hyperthermia in acute stroke: a significant clinical concern
    M D Ginsberg
    Cerebral Vascular Disease Research Center, Department of Neurology, University of Miami School of Medicine, Fla 33101, USA
    Stroke 29:529-34. 1998
    ..for our recommendation that physicians treating acute cerebral ischemia or traumatic brain injury diligently monitor their patients for incipient fever and take prompt measures to maintain core-body temperature at normothermic levels.
  78. ncbi The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: a review of pharmacological and genetic studies in the mouse
    J Adriaan Bouwknecht
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neurosci Biobehav Rev 31:41-59. 2007
    ..The advantages and disadvantages of the SIH procedure as a physiological model of anxiety are discussed...
  79. ncbi The Multinational Association for Supportive Care in Cancer risk index: A multinational scoring system for identifying low-risk febrile neutropenic cancer patients
    J Klastersky
    Institut Jules Bordet, Brussels, Belgium
    J Clin Oncol 18:3038-51. 2000
    ..The purpose of this study was to develop an internationally validated scoring system to identify these patients...
  80. doi An infectious cDNA clone of a highly pathogenic porcine reproductive and respiratory syndrome virus variant associated with porcine high fever syndrome
    Jian Lv
    China Agricultural University, College of Biological Sciences, Beijing 100094, PR China
    J Gen Virol 89:2075-9. 2008
    Since May 2006, a so-called 'porcine high fever syndrome' (PHFS) has spread all over China...
  81. pmc Interactions between age and ITN use determine the risk of febrile malaria in children
    Philip Bejon
    Kenyan Medical Research Institute KEMRI, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS ONE 4:e8321. 2009
    ..However, the more common practice in Sub-Saharan Africa is to target ITN distribution on young children. There are few data on the long term outcomes of this practice...
  82. ncbi Fever in the elderly
    D C Norman
    Department of Medicine, Division of Geriatrics, University of California of Los Angeles School of Medicine, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Clin Infect Dis 31:148-51. 2000
    ..b>Fever, the cardinal sign of infection, may be absent or blunted 20%-30% of the time...
  83. ncbi Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure
    G Hilbert
    Division of Medical Intensive Care, University Hospital, Bordeaux, France
    N Engl J Med 344:481-7. 2001
    ..Avoiding intubation is a major goal in the management of respiratory failure, particularly in immunosuppressed patients. Nevertheless, there are only limited data on the efficacy of noninvasive ventilation in these high-risk patients...
  84. doi First-day step-down to oral outpatient treatment versus continued standard treatment in children with cancer and low-risk fever in neutropenia. A randomized controlled trial within the multicenter SPOG 2003 FN study
    Eva Brack
    Department of Pediatrics, University of Bern, Bern, Switzerland
    Pediatr Blood Cancer 59:423-30. 2012
    The standard treatment of fever in chemotherapy-induced neutropenia (FN) includes emergency hospitalization and empirical intravenous antimicrobial therapy...
  85. pmc Clinical features and factors associated with severity and fatality among patients with severe fever with thrombocytopenia syndrome Bunyavirus infection in Northeast China
    Baocheng Deng
    Department of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province, China
    PLoS ONE 8:e80802. 2013
    In 2009, severe fever with thrombocytopenia syndrome virus (SFTSV) was identified as a novel member of the genus phlebovirus in the Bunyaviridae family in China...
  86. ncbi Neutropenia-related costs in patients treated with first-line chemotherapy for advanced non-small cell lung cancer
    Michael E Stokes
    United BioSource Corporation, 185 Dorval Ave, Ste 500, Dorval, QC, H9S 5J9, Canada
    J Manag Care Pharm 15:669-82. 2009
    ..Neutropenia-related complications often lead to increased use of costly health care including inpatient and outpatient services. Monitoring and treatment of neutropenia thus place an economic burden on the health care system...
  87. ncbi [Epidemiologic analysis on severe fever with thrombocytopenia syndrome in Hubei province, 2010]
    Li Liu
    Hubei Provincial Center for Disease Control and Prevention, Wuhan, China
    Zhonghua Liu Xing Bing Xue Za Zhi 33:168-72. 2012
    To identify the epidemic characteristics and risk factors of an emerging infectious disease-severe fever with thrombocytopenia syndrome (SFTS) in Hubei province.
  88. pmc Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret model
    Kim L Roberts
    Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 7:e43303. 2012
    ..animal model in which this can be assessed because they display typical influenza-like clinical signs including fever and sneezing after infection...
  89. doi Beliefs and expectations of Canadian parents who bring febrile children for medical care
    Mark C Enarson
    Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Pediatrics 130:e905-12. 2012
    The purpose of this survey was to study the beliefs, expectations, and satisfaction of Canadian parents regarding fever and the treatment of their febrile children.
  90. ncbi Stroke severity determines body temperature in acute stroke
    G Boysen
    Department of Neurology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Stroke 32:413-7. 2001
    ..Experimental studies showing that hyperthermia increases infarct size have lent credibility to this assumption. The aim of the present study was to test the hypothesis that initial body temperature is of importance for stroke outcome...
  91. ncbi A prospective study of bloodstream infections as cause of fever in Malawi: clinical predictors and implications for management
    Remco P H Peters
    Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi
    Trop Med Int Health 9:928-34. 2004
    To determine the contribution of a blood culture service to the diagnosis of fever in a resource-poor setting and to identify clinical predictors of specific bloodstream infections (BSI).
  92. ncbi The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study
    Carl I Schulman
    Division of Trauma and Surgical Critical Care, University of Miami Leonard M Miller School of Medicine, Miami, Florida 33101, USA
    Surg Infect (Larchmt) 6:369-75. 2005
    Despite the large body of evidence suggesting a beneficial role of fever in the host response, antipyretic therapy is commonly employed for febrile critically ill patients...
  93. ncbi Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma
    Tamas Bartfai
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
    Ann N Y Acad Sci 1113:173-7. 2007
    ..In seizures, IL-1ra is a strong anticonvulsant and in IL-1beta-dependent fever, a powerful antipyretic...
  94. ncbi Comparing different patterns for managing febrile children in the ED between emergency and pediatric physicians: impact on patient outcome
    Vei Ken Seow
    Emergency Department, Shin Kong Wu Ho Su Memorial Hospital, Taipei 111, Taiwan
    Am J Emerg Med 25:1004-8. 2007
    The management of children with fever of indefinite source still remains controversial...
  95. pmc Performance of Interleukin-6 and Interleukin-8 serum levels in pediatric oncology patients with neutropenia and fever for the assessment of low-risk
    Miriam Diepold
    Department of Pediatric Oncology and Hematology, University Hospital of Bern, 3010 Bern, Switzerland
    BMC Infect Dis 8:28. 2008
    Patients with chemotherapy-related neutropenia and fever are usually hospitalized and treated on empirical intravenous broad-spectrum antibiotic regimens...
  96. doi Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever
    Sharon Sanders
    The School of Medicine, The University of Queensland, Royal Brisbane Hospital Complex, Queensland, Brisbane, Australia
    J Pediatr 153:570-4. 2008
    To determine the accuracy of C-reactive protein (CRP) for diagnosing serious bacterial and bacterial infections in infants and children presenting with fever.
  97. pmc Autism, fever, epigenetics and the locus coeruleus
    Mark F Mehler
    Institute for Brain Disorders and Neural Regeneration, The Saul R Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Brain Res Rev 59:388-92. 2009
    ..We hypothesize that febrigenesis and the behavioral-state changes associated with fever in autism depend upon selective normalization of key components of a functionally impaired locus coeruleus-..
  98. doi Parental fever attitude and management: influence of parental ethnicity and child's age
    Ruud G Nijman
    Department of Paediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Emerg Care 26:339-42. 2010
    The objective was to study parental fever management and attitude toward fever from the perspective of the child's ethnicity and age.
  99. doi Unknown fever and back pain caused by Bartonella henselae in a veterinarian after a needle puncture: a case report and literature review
    Jen Wei Lin
    Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    Vector Borne Zoonotic Dis 11:589-91. 2011
    ..He sought for clinical help because of unknown fever and persistent back pain for at least a month after an accidental needle puncture...
  100. pmc Fever detection in under 5 children in a tertiary health facility using the infrared tympanic thermometer in the oral mode
    Benedict O Edelu
    Department of Pediatrics, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria
    Ital J Pediatr 37:8. 2011
    ..procedure in the care of sick children, especially the under-5 children, as many disease conditions present with fever. The oral mercury-in-glass thermometer which has relatively good accuracy cannot be used in children less than 5 ..
  101. pmc A clinical diagnostic model for predicting influenza among young adult military personnel with febrile respiratory illness in Singapore
    Vernon J Lee
    Biodefence Centre, Ministry of Defence, Singapore, Singapore
    PLoS ONE 6:e17468. 2011
    ..We aim to compare the differences in presentation between influenza and non-influenza cases among those with febrile respiratory illness (FRI) to determine predictors of influenza infection...

Research Grants78

  1. Merrill D Benson; Fiscal Year: 2014
    ..disease), and inherited recurrent febrile diseases such as the autosomal recessive familial Mediterranean fever (FMF), and a group of autosomal dominant syndromes including TNF-alpha receptor associated periodic syndrome (..
  2. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..Infants and young children are particularly vulnerable to fasting, and this is significantly exacerbated by fever and viral infections, which are common in this age group...
  3. Group A Streptococcus responses to oxidative stress
    Ioannis Gryllos; Fiscal Year: 2010
    ..as well as life threatening invasive disease and the post-streptococcal autoimmune conditions of acute rheumatic fever and heart disease...
  4. Systematics of medically important Dermacentor tick vectors
    Dmitry A Apanaskevich; Fiscal Year: 2011
    ..and veterinary perspectives;for example, they are vectors of Rickettsia rickettsii causing Rocky Mountain spotted fever;Rickettsia sibirica causing North Asian tick typhus;Rickettsia conori causing Boutenneuse fever;Francisella ..
  5. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..Heart failure has many causes, congenital defects and infections induced rheumatic fever, are among the most common symptoms lead to heart valve disease...
  6. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) are diseases caused by 4 serotypes of dengue virus (DV)...
  7. Fatty acid related regulation of enteric infectious disease
    FREDRICK JON KULL; Fiscal Year: 2012
    ..pathogenic activity, thereby laying the groundwork for development of therapeutics that could be broadly applied to treat enteric bacterial infections causing diseases such as travelers'diarrhea, dysentery, and typhoid fever.
  8. Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2009
    The mosquito-borne flaviviruses include the NIAID list of Class A, B, or C emerging human pathogens such as Yellow fever virus (YFV), West Nile virus (WNV) and Dengue (DEN1-4) viruses that cause serious illnesses with considerable ..
  9. Roy Curtiss Iii; Fiscal Year: 2016
    ..features to ensure safety and efficacy when used to immunize infants and adults to protect against enteric fever and an additional infectious disease such as caused by HBV, (iv) to design, construct and evaluate a recombinant ..
  10. ARUNKUMAR GOVINDAKARNAVAR; Fiscal Year: 2016
    ..have greatly enhanced understanding of the infectious etiologies of Acute Febrile Illness (AFI) such as fever of more than a week's duration, including that of Kyasanur Forest Disease (KFD), Leptospirosis, Rickettsial ..
  11. Systemic AA Amyloidosis Inhibitors
    ALAN D SNOW; Fiscal Year: 2010
    ..bowl disease, tuberculosis, leprosy, Hodgkin's disease, renal cell carcinoma, and Familial Mediterranean Fever. The consequences of fibrillar AA amyloid deposition in systemic organs are usually fatal to patients, with most ..
  12. Biochemistry and Function of a Novel Bacterial Photosensory Two-Component System
    MELISSA MARKS; Fiscal Year: 2010
    ..to the World Health Organization, over 130,000 cases of cholera (Vibrio cholerae) and 17 million cases of Typhoid fever (Salmonella typhi) occur annually...
  13. Rafi Ahmed; Fiscal Year: 2016
    ..To achieve these goals, we studied one of the most effective human vaccines ever developed, the yellow fever vaccine-17D (YFV-17D) as a model...
  14. Linda J Kenney; Fiscal Year: 2016
    ..g. military bases, hospitals or nursing homes). The number of typhoid fever cases exceeds 33 million per year worldwide and remains a potential concern among previously vaccinated travelers ..
  15. Analysis of the functions of axon guidance genes during vector mosquito developme
    MOLLY DUMAN SCHEEL; Fiscal Year: 2012
    ..These studies will include the yellow and dengue fever virus vector Aedes aegypti, as well as the malaria vector Anopheles gambiae...
  16. Lynda G Tussey; Fiscal Year: 2015
    ..because sequential infection by different dengue virus serotypes can lead to life-threatening dengue hemorrhagic fever or dengue shock syndrome...
  17. Diane E Griffin; Fiscal Year: 2016
    ..Arthropod-borne (arbo) viruses, most importantly alphaviruses and flaviviruses, cause widespread epidemics of fever, encephalitis and arthritis and pose increasing threats to human populations through expansion into new geographic ..
  18. ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2016
    ..Human granulocytic anaplasmosis (HGA) is a severe illness with a fatality rate of <5% that, like spotted fever, is caused by tick-borne intracellular bacteria, presenting a highly relevant, challenging opportunity to study ..
  19. Role of surface proteins in sand fly colonization by Bartonella bacilliformis
    Michael F Minnick; Fiscal Year: 2013
    ..regions, the disease manifests as an acute illness with an ~80% reduction in erythrocyte hematocrit (Oroya fever), whereas in endemic regions, angiomatous skin lesions (verruga peruana) and chronic bacteremia prevail, creating ..
  20. Pathogenesis of autoimmune endocarditis: roles for Fc receptors and integrins?
    Bryce Binstadt; Fiscal Year: 2012
    ..In particular, inflammation of the cardiac valves occurs in rheumatic fever (rheumatic carditis) and in SLE and the related antiphospholipid syndrome (Libman-Sacks endocarditis)...
  21. Programming of Protective CD8 T-Cell Memory by Live and Adjuvanted Subunit Vaccin
    Marulasiddappa Suresh; Fiscal Year: 2013
    ..Live attenuated vaccines have been highly effective in controlling human infections such as smallpox, yellow fever, measles, mumps, rubella, and chicken pox...
  22. Role of Coxiella burnetii group I introns in growth modulation
    Michael F Minnick; Fiscal Year: 2010
    ..by applicant): Coxiella burnetii is an extremely infectious, obligate intracellular bacterium that causes Q fever, and is classified as a Select B Agent...
  23. Pirooz Eghtesady; Fiscal Year: 2014
    ..elevated anti-human cardiac myosin serum titers in mothers of HLHS babies (as found in patients with rheumatic fever), compared with three control groups...
  24. Metal-dependent phosphohydrolase activity of CvfA from Streptococcus pyogenes
    GABRIELA CITLALLI PEREZ-ALVARADO; Fiscal Year: 2012
    ..Group A Streptococcus (GAS) is associated with a broad range of human diseases including scarlet fever, impetigo, pharyngitis, necrotizing fasciitis, streptococcal toxic shock syndrome and the post- streptococcal ..
  25. Nikkomycin Z treatment of early coccidioidal pneumonia: Phase II clinical trial
    DAVID LARWOOD; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Coccidioidomycosis (Valley Fever) is an orphan fungal infection endemic to the US southwest, for which approximately 50,000 persons seek medical attention each year...
  26. Endemic maintenance of relapsing fever genotypes.
    Michael Bela Teglas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Relapsing fever is a vector-borne disease long associated with poverty and human suffering in areas of social disruption across Africa and Asia. In the western U.S...
  27. Brain interleukin-18 control of food intake and energy expenditure
    Eric P Zorrilla; Fiscal Year: 2013
    ..in hungry mice as potently as does the adipocyte hormone leptin and does so without producing the adverse malaise, fever or HPA-axis activation classically associated with proinflammatory cytokine-driven "sickness" anorexia...
  28. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2012
    ..Test the hypothesis that an upregulated endothelial IL15 system enhances TNF-induced neuroinflammation, shown by fever, sickness behavior, reactive gliosis, and cerebral production of proinflammatory cytokines...
  29. Juan J Martinez; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Rickettsia conorii, a member of the spotted fever group (SFG) rickettsia is an obligate intracellular tick borne pathogen and is the causative agent of Mediterranean spotted fever...
  30. Virus interference with Toll like Receptor Response on Dendritic Cells
    Elina I Zuniga; Fiscal Year: 2010
    ..obtained from this project will help in understanding the pathogenesis of the life threatening human hemorrhagic fever arenaviruses...
  31. Impact of Temperature Profile on Outcome After Traumatic Brain Injury
    Lori Kennedy Madden; Fiscal Year: 2013
    ..in trauma resuscitation with TBI, temperature management goals after TBI, and timing of interventions to prevent/minimize fever after TBI. Finally, temperature management following TBI may improve outcomes at a relatively low cost.
  32. Slobodan Paessler; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Several arenaviruses cause hemorrhagic fever (HF) disease in humans and pose a serious threat to public health within their endemic regions...
  33. Preventing lethal hemorrhagic fever caused by hantaviruses by preserving endothel
    ALAN L MUELLER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Viral hemorrhagic fever (VHF) activates the innate immune system triggering an exuberant release of cytokines and other permeability factors that destabilize the endothelial barrier...
  34. Determining Molecular Mechanisms of Chikungunya Virulence and Attenuation
    KATHERINE D RYMAN; Fiscal Year: 2010
    ..Since early 2005, a CHIKV epidemic has been responsible for over 1.5 million cases of CHIK fever in India and the Indian Ocean islands of Riunion, Mauritius, Madagascar and Seychelles...
  35. Genetic Analysis of Mosquito Metamorphosis
    James T Nishiura; Fiscal Year: 2012
    Yearly, millions of people die, or are seriously debilitated, from malaria, dengue fever, yellow fever and several forms of viral encephalitis. Hematophageous mosquitoes transmit the causative agents of these diseases [1, 2]...
  36. Fatty Acid Synthase Inhibitors As Broad Spectrum Anti-Flaviviral Therapeutics
    Glenn Randall; Fiscal Year: 2013
    ..FASN inhibitors block the replication of DENV and other flaviviruses including West Nile virus and yellow fever virus...
  37. Md Yunus; Fiscal Year: 2014
    ..cause of mortality and morbidity in Bangladesh, some of the most common water related diseases being typhoid fever, bacillary dysentery, and diarrhea...
  38. IRES-mediated translation initiation on viral mRNAs
    CHRISTOPHER ULRICH TRISTRAM HELLEN; Fiscal Year: 2013
    ..The IRES of classical swine fever virus, a pestivirus, is substantially resistant to inhibition by eIF2 phosphorylation, which can be accounted for ..
  39. Antiviral potential of helicase inhibitors
    David N Frick; Fiscal Year: 2012
    ..hepatitis C virus (HCV), Dengue virus (DENV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), and human immunodeficiency virus (HIV)...
  40. Eric S Johnson; Fiscal Year: 2015
    ..manufactured by growing the vaccine virus in chicken embryos such as measles, mumps, influenza, and yellow-fever vaccines, that may contain exogenous and endogenous forms of these oncogenic viruses...
  41. Development of Site-Specific Mutagenesis in Coxiella burnetti
    JAMES EVANS SAMUEL; Fiscal Year: 2012
    ..a Gram-negative obligate intracellular bacterium, is the etiological agent of acute and chronic Q (query) fever in humans. Analysis of C...
  42. Microbial regulation of intestinal gene expression through microRNA
    Sushila Dalal; Fiscal Year: 2012
    ..Hsps protect the intestinal epithelium from stressors such as heat (fever), inflammation, starvation, and infection...
  43. Thomas R Kozel; Fiscal Year: 2014
    ..of concept for the InMAD approach to target discovery is already in hand for tularemia, melioidosis and relapsing fever where candidate proteins and polysaccharides that are shed into serum during infection have been identified...
  44. Extracellular Replication of Listeria in Vivo
    Christopher H Contag; Fiscal Year: 2010
    ..grows inside the gallbladder, which is highly unusual and unique in any animal model, and resembles human typhoid fever. We propose to use molecular imaging techniques to learn how this bacterium colonizes the gallbladder, ..
  45. Charles R Sanders; Fiscal Year: 2016
    ..Members of the MAPEG superfamily are involved in several aspects of the regulation of pain, fever, inflammation and allergic response in humans...
  46. Molecular probes for a vOTU from CCHFV using a fluorogenic peptide
    SCOTT DUSAN PEGAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Crimean-Congo hemorrhagic fever (CCHF) virus is a ssRNA (-) Nairovirus that produces fever, prostration, and severe hemorrhages in humans...
  47. REBECCA R RICO-HESSE; Fiscal Year: 2016
    ..Dengue virus is a single-stranded RNA Flavivirus that causes dengue fever (DF), the most prevalent arthropod-borne viral illness in humans...
  48. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..Experimental exposure of Swiss Webster mice to the isolate at 1X103 PFU/eye resulted in mild eye disease and fever. Viral DNA was detected in spleen tissue during the acute infection, and was detectable in the TG after 20 day ..
  49. Functional genomics of human variation to Salmonella invasion
    DENNIS CHUN YONE KO; Fiscal Year: 2013
    ..elucidate how human genetic differences contribute to variation in infection by the bacteria that causes typhoid fever, Salmonella typhi. The first aim is to identify human genetic differences that modify invasion of S...
  50. Central Sympathetic Regulation of Thermogenesis in Fever
    Shaun F Morrison; Fiscal Year: 2013
    Project Summary Fever is a defended elevation in body temperature that plays a significant role in the acute phase reaction stimulated by a cascade of endogenous pyrogens released during infection...
  51. Novel mechanisms by which aspirin might protect against atherosclerosis
    Sampath Parthasarathy; Fiscal Year: 2012
    ..acid') inhibits the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever. Recent studies also suggest that aspirin may have other modes of action, including the induction of nitric oxide ..
  52. Short-term responses to temperature changes in Escherichia coli
    Christine A White Ziegler; Fiscal Year: 2010
    ..intermediate temperatures between 23[unreadable]C and 37[unreadable]C and at 40[unreadable]C, indicative of a host fever response, will uncover what temperature ranges program a characterized thermoregulatory response...
  53. Small Regulatory RNAs of Coxiella burnetii - The Agent of Q Fever
    JAMES MICHAEL BATTISTI; Fiscal Year: 2013
    ..provided by applicant): Coxiella burnetii is an extremely infectious, intracellular bacterium that causes Q fever in humans and is classified as a select agent...
  54. Abdu F Azad; Fiscal Year: 2016
    ..The illness is accompanied by fever, headache, chills, vomiting, nausea, myalgia, and rash and leads to disseminated multisystem disease...
  55. Raymond J St Leger; Fiscal Year: 2015
    ..in areas where mosquito-borne diseases including malaria, filariasis, viral encephalitides, dengue and yellow fever are endemic...
  56. Development of Therapeutic Pan-Filovirus Macaque Monoclonal Antibodies
    Sven G Enterlein; Fiscal Year: 2013
    ..provided by applicant): Filoviruses, Ebola (EBOV) and Marburg (MARV), are causative agents of sever hemorrhagic fever in humans with case-fatality rates exceeding 88%...
  57. Fitness and Virulence of Dengue Virus in the Context of Changing Host Immunity
    Eva Harris; Fiscal Year: 2012
    ..DENV infection results in dengue fever, an acute febrile illness, or the more severe, life- threatening dengue hemorrhagic fever/dengue shock syndrome...
  58. MECHANISMS OF SALMONELLA INVASION AND TRANSMIGRATION
    James E Casanova; Fiscal Year: 2013
    ..Salmonella strains causes symptoms ranging from gastritis to potentially fatal systemic disease such as Typhoid Fever. The goals of this research are to define the host cell machinery that is subverted by Salmonella to enter the ..
  59. Mucosal innate immune defense to Rift Valley fever virus
    Amy G Hise; Fiscal Year: 2010
    ..study will define mucosal virulence and mechanism of innate immune host defense against aerosolized Rift Valley fever virus, a Category A biodefense pathogen...
  60. Stephen Obaro; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Typhoid fever is caused by Salmonella enteric serovar Typhi (S. typhi), a human specific pathogen...
  61. Development of a Recombinant Subunit Vaccine for CCHF
    David E Clements; Fiscal Year: 2013
    ..Crimean-Congo hemorrhagic fever virus (CCHFV) is a significant human pathogen due to it ability cause severe disease and its high fatality rate...
  62. Age-associated Toll-like receptor dysfunction in the lungs
    Carlos J Orihuela; Fiscal Year: 2010
    ..severe in the elderly;2) why 10% of the elderly with pneumonia show no overt clinical signs of infection such as fever, cough, or dyspnea;and 3) why lack of fever is a prognostic indicator of poor clinical outcome...
  63. Bioavailable proteasome inhibitors as broad-spectrum antivirals
    ALEXANDER NICLAS FREIBERG; Fiscal Year: 2013
    ..of multiple Category A-C pathogens: Filoviridae (Ebola), Paramyxoviridae (Nipah), Bunyaviridae (Rift Valley fever), Flaviviridae (Russian-Spring-Summer encephalitis), and Arenaviridae (Junin)...
  64. A Novel Method of Generating Hepatitis C Virus-Like Particles using Lentivirus
    Boro Dropulic; Fiscal Year: 2009
    ..such as AIDS but also for a wide range of other viral diseases of clinical interest such as hepatitis C, yellow fever, West Nile fever, dengue fever, and influenza...
  65. Mosquito Vector Control Using Bt Coupled to Seed Oil Bodies
    Mohd Amir Abdullah; Fiscal Year: 2009
    ..Mosquitoes are the insect vectors for numerous blood-borne human diseases including malaria, West Nile fever, yellow fever, and dengue that cause millions of deaths each year worldwide...
  66. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Five Bartonella species are emerging infectious agents responsible for Oroya fever, cat-scratch disease, bacillary angiomatosis, and trench fever in humans...
  67. Rickettsia ricketti and Rickettsia-like organisms in Maryland
    Douglas Norris; Fiscal Year: 2009
    ..The best known of the human rickettsial infections is Rocky Mountain Spotted Fever (RMSF), a disease that maintains a fatality rate of 3-10%, even with modern medical care...
  68. Culture and Identification of Rickettsia-like Organisms in Maryland
    Douglas E Norris; Fiscal Year: 2010
    ..The best known of the human rickettsial infections is responsible for Rocky Mountain Spotted Fever (RMSF), a disease that has remained severe with a fatality rate of 3-10%, even with modern medical care...
  69. MOLECULAR EPIDEMIOLOGY AND ECOLOGY OF OROPOUCHE VIRUS
    Alan Barrett; Fiscal Year: 2000
    Oropouche (ORO) fever is vector-borne viral disease, transmitted by the biting-midge Culicoides paraensis, which during the past 40 years has emerged as an increasing public health problem in South America...
  70. Molecular Etiology of Familial Mediterranean Fever
    Deborah Gumucio; Fiscal Year: 2007
    Patients with the autosomal recessive disease, Familial Mediterranean fever (FMF), suffer periodic, upredictable attacks of fever associated with severe pain; the pain is localized most commonly in joints (arthritis), abdomen (..
  71. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..and to genetically diverse human populations, and lacking cytotoxic T-cell epitopes associated with hemorrhagic fever. The combination of epitope selection, targeting to the MHC II compartment, and ex vivo analysis of the immune ..
  72. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ..Among them are Rocky Mountain spotted fever and epidemic typhus caused respectively by R. rickettsii and R. prowazekii...
  73. Phase II, IL-1 Trap for Treatment of Familial Mediterranean Fever
    Steven J Spalding; Fiscal Year: 2010
    Familial Mediterranean fever is an autosomal recessive autoinflammatory genetic disorder resulting in recurrent episodes of fever, serositis, arthritis and rash...