cachexia

Summary

Summary: General ill health, malnutrition, and weight loss, usually associated with chronic disease.

Top Publications

  1. ncbi Cachexia: pathophysiology and clinical relevance
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, 1042 South Grand Boulevard M238, St Louis, MO 63104, USA
    Am J Clin Nutr 83:735-43. 2006
  2. ncbi Cachexia: a new definition
    William J Evans
    Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
    Clin Nutr 27:793-9. 2008
  3. ncbi Mechanisms of cancer cachexia
    Michael J Tisdale
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Physiol Rev 89:381-410. 2009
  4. ncbi Definition and classification of cancer cachexia: an international consensus
    Kenneth Fearon
    Clinical and Surgical Sciences, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Lancet Oncol 12:489-95. 2011
  5. ncbi Cancer cachexia: mediators, signaling, and metabolic pathways
    Kenneth C H Fearon
    Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh EH16 4SA, UK
    Cell Metab 16:153-66. 2012
  6. ncbi IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
    Dongsheng Cai
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Cell 119:285-98. 2004
  7. ncbi Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival
    Xiaolan Zhou
    Departments of Metabolic Disorders and Protein Science, Amgen Research, Thousand Oaks, CA 91320, USA
    Cell 142:531-43. 2010
  8. ncbi Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics"
    M Muscaritoli
    Department of Clinical Medicine, La Sapienza, University of Rome, Viale dell Universita, 37, Rome 00185, Italy
    Clin Nutr 29:154-9. 2010
  9. ncbi Adipose triglyceride lipase contributes to cancer-associated cachexia
    Suman K Das
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Science 333:233-8. 2011
  10. ncbi Cachexia in cancer patients
    Michael J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Nat Rev Cancer 2:862-71. 2002

Detail Information

Publications330 found, 100 shown here

  1. ncbi Cachexia: pathophysiology and clinical relevance
    John E Morley
    Division of Geriatric Medicine, Saint Louis University School of Medicine, 1042 South Grand Boulevard M238, St Louis, MO 63104, USA
    Am J Clin Nutr 83:735-43. 2006
    b>Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration...
  2. ncbi Cachexia: a new definition
    William J Evans
    Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
    Clin Nutr 27:793-9. 2008
    On December 13th and 14th a group of scientists and clinicians met in Washington, DC, for the cachexia consensus conference. At the present time, there is no widely agreed upon operational definition of cachexia...
  3. ncbi Mechanisms of cancer cachexia
    Michael J Tisdale
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Physiol Rev 89:381-410. 2009
    Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a shortened survival time...
  4. ncbi Definition and classification of cancer cachexia: an international consensus
    Kenneth Fearon
    Clinical and Surgical Sciences, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Lancet Oncol 12:489-95. 2011
    To develop a framework for the definition and classification of cancer cachexia a panel of experts participated in a formal consensus process, including focus groups and two Delphi rounds...
  5. ncbi Cancer cachexia: mediators, signaling, and metabolic pathways
    Kenneth C H Fearon
    Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh EH16 4SA, UK
    Cell Metab 16:153-66. 2012
    Cancer cachexia is characterized by a significant reduction in body weight resulting predominantly from loss of adipose tissue and skeletal muscle...
  6. ncbi IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
    Dongsheng Cai
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Cell 119:285-98. 2004
    Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and immobilization...
  7. ncbi Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival
    Xiaolan Zhou
    Departments of Metabolic Disorders and Protein Science, Amgen Research, Thousand Oaks, CA 91320, USA
    Cell 142:531-43. 2010
    Muscle wasting and cachexia have long been postulated to be key determinants of cancer-related death, but there has been no direct experimental evidence to substantiate this hypothesis...
  8. ncbi Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics"
    M Muscaritoli
    Department of Clinical Medicine, La Sapienza, University of Rome, Viale dell Universita, 37, Rome 00185, Italy
    Clin Nutr 29:154-9. 2010
    ..Based on these premises, the Special Interest Group (SIG) on cachexia-anorexia in chronic wasting diseases was created within ESPEN with the aim of developing and spreading the ..
  9. ncbi Adipose triglyceride lipase contributes to cancer-associated cachexia
    Suman K Das
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Science 333:233-8. 2011
    b>Cachexia is a multifactorial wasting syndrome most common in patients with cancer that is characterized by the uncontrolled loss of adipose and muscle mass...
  10. ncbi Cachexia in cancer patients
    Michael J Tisdale
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Nat Rev Cancer 2:862-71. 2002
  11. pmc Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy
    Sarah A Reed
    Department of Physical Therapy, 101 S Newell Dr, University of Florida, Gainesville, FL 32611, USA
    FASEB J 26:987-1000. 2012
    b>Cachexia is characterized by inexorable muscle wasting that significantly affects patient prognosis and increases mortality. Therefore, understanding the molecular basis of this muscle wasting is of significant importance...
  12. pmc PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice
    Tuoyu Geng
    Department of Medicine Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 178:1738-48. 2011
    ..These findings suggest that PGC-1α protects muscle from catabolic wasting in chronic heart failure through enhanced nitric oxide antioxidant defenses and inhibition of the forkhead transcription factor signaling pathways...
  13. ncbi Skeletal muscle loss: cachexia, sarcopenia, and inactivity
    William J Evans
    Division of Geriatrics, Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
    Am J Clin Nutr 91:1123S-1127S. 2010
    Loss of skeletal muscle mass occurs during aging (sarcopenia), disease (cachexia), or inactivity (atrophy). This article contrasts and compares the metabolic causes of loss of muscle resulting from these conditions...
  14. pmc STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia
    Andrea Bonetto
    Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 6:e22538. 2011
    b>Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients...
  15. ncbi Wasting as independent risk factor for mortality in chronic heart failure
    S D Anker
    Department of Cardiac Medicine, National Heart and Lung Institute, London
    Lancet 349:1050-3. 1997
    ..Wasting in chronic heart failure (CHF) has long been known but is little investigated. We sought to find out whether the cachectic state in CHF provides additional prognostic information about all-cause mortality...
  16. ncbi Induction of cachexia in mice by systemically administered myostatin
    Teresa A Zimmers
    Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 296:1486-8. 2002
    ..of myostatin in adult mice was found to induce profound muscle and fat loss analogous to that seen in human cachexia syndromes...
  17. pmc JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia
    Andrea Bonetto
    Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Physiol Endocrinol Metab 303:E410-21. 2012
    b>Cachexia, the metabolic dysregulation leading to sustained loss of muscle and adipose tissue, is a devastating complication of cancer and other chronic diseases...
  18. pmc Nerve growth factor links oral cancer progression, pain, and cachexia
    Yi Ye
    Bluestone Center for Clinical Research, New York University College of Dentistry, 421 First Avenue, 233W, New York, NY 10010, USA
    Mol Cancer Ther 10:1667-76. 2011
    ..Cancer-induced pain and cachexia are often studied and treated independently, although both symptoms are strongly linked with chronic inflammation ..
  19. pmc The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice
    Sergio Di Marco
    Department of Biochemistry, Rosalind and Morris Goodman Cancer Center, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada
    Nat Commun 3:896. 2012
    b>Cachexia, or muscle-wasting syndrome, is one of the major causes of death in patients affected by diseases such as cancer, AIDS and sepsis. However, no effective anti-cachectic treatment is currently available...
  20. pmc Cancer cachexia--pathophysiology and management
    Hajime Suzuki
    Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
    J Gastroenterol 48:574-94. 2013
    About half of all cancer patients show a syndrome of cachexia, characterized by anorexia and loss of adipose tissue and skeletal muscle mass...
  21. ncbi A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
    G A Taylor
    Howard Hughes Medical Institute Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunity 4:445-54. 1996
    ..normal at birth, but soon manifested marked medullary and extramedullary myeloid hyperplasia associated with cachexia, erosive arthritis, dermatitis, conjunctivitis, glomerular mesangial thickening, and high titers of anti-DNA and ..
  22. ncbi The role of C-reactive protein as a prognostic indicator in advanced cancer
    Fade Aziz Mahmoud
    Taussig Cancer Center, The Cleveland Clinic Foundation, M76, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Oncol Rep 4:250-5. 2002
    ..It is positively correlated with weight loss, anorexia-cachexia syndrome, extent of disease, and recurrence in advanced cancer...
  23. ncbi Systemic inflammation, nutritional status and survival in patients with cancer
    Donald C McMillan
    University Department of Surgery, Faculty of Medicine University of Glasgow, Royal Infirmary, Glasgow, UK
    Curr Opin Clin Nutr Metab Care 12:223-6. 2009
    ..good evidence in humans that a chronic systemic inflammatory response results in the cardinal features of cancer cachexia, principally the progressive loss of weight (in particular lean tissue)...
  24. ncbi An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer
    Donald C McMillan
    University Dept of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Proc Nutr Soc 67:257-62. 2008
    ..The aetiology of such weight loss or cachexia is complex and involves both tumour and host responses...
  25. pmc Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatment
    Nagi B Kumar
    Department of Population Sciences, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Curr Treat Options Oncol 11:107-17. 2010
    The complex syndrome of cancer cachexia (CC) that occurs in 50% to 80% cancer patients has been identified as an independent predictor of shorter survival and increased risk of treatment failure and toxicity, contributing to the mortality ..
  26. ncbi Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index
    Lisa Martin
    University of Alberta, Edmonton, Alberta, Canada
    J Clin Oncol 31:1539-47. 2013
    ..Emerging evidence suggests muscle depletion predicts survival of patients with cancer...
  27. pmc Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia
    P Costelli
    Dipartimento di Medicina ed Oncologia Sperimentale, Sezione di Patologia Generale, , Italy
    Br J Cancer 84:946-50. 2001
    b>Cachexia is a syndrome characterized by profound tissue wasting that frequently complicates malignancies...
  28. ncbi Systemic inflammation, cachexia and prognosis in patients with cancer
    Christopher Deans
    Tissue Injury and Repair Group, MRC Centre for Inflammation Research, Department of Clinical and Surgical Sciences, Medical School, Edinburgh University, Scotland, UK
    Curr Opin Clin Nutr Metab Care 8:265-9. 2005
    b>Cachexia remains an important cause of morbidity and mortality among cancer patients. The mechanisms underlying this syndrome remain unclear and are almost certainly multifactorial...
  29. ncbi The mechanisms of cachexia underlying muscle dysfunction in COPD
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Appl Physiol (1985) 114:1253-62. 2013
    Pulmonary cachexia is a prevalent, debilitating, and well-recognized feature of COPD associated with increased mortality and loss of peripheral and respiratory muscle function...
  30. ncbi Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib ± megestrol acetate for patients with cancer-related anorexia/cachexia syndrome
    Clelia Madeddu
    Department of Medical Oncology, University of Cagliari, Cagliari, Italy
    Clin Nutr 31:176-82. 2012
    ..e. antioxidants) with carnitine + celecoxib ± megestrol acetate for the treatment of cancer-related anorexia/cachexia syndrome (CACS): the primary endpoints were increase of lean body mass (LBM) and improvement of total daily ..
  31. ncbi A randomized phase III clinical trial of a combined treatment for cachexia in patients with gynecological cancers: evaluating the impact on metabolic and inflammatory profiles and quality of life
    Antonio Maccio
    Department of Obstetrics and Gynecology, Sirai Hospital, Carbonia, Italy
    Gynecol Oncol 124:417-25. 2012
    ..alterations and by symptoms including fatigue, anorexia, nausea, anemia, and immunodepression, which result in a cachexia syndrome and a marked decrease in patient quality of life (QoL)...
  32. pmc The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse
    James P White
    Department of Exercise Science, University of South Carolina, Columbia, South Carolina, United States of America
    PLoS ONE 6:e24650. 2011
    Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation...
  33. pmc Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse
    Paola Aulino
    Department of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 16, 00161 Rome, Italy
    BMC Cancer 10:363. 2010
    The majority of cancer patients experience dramatic weight loss, due to cachexia and consisting of skeletal muscle and fat tissue wasting...
  34. ncbi Rheumatoid cachexia and cardiovascular disease
    Gregory D Summers
    Department of Rheumatology, Royal Derby Hospital, Derby DE22 3NE, UK
    Nat Rev Rheumatol 6:445-51. 2010
    Both cachexia and cardiovascular disease are strongly associated with rheumatoid arthritis (RA) and linked to the chronic inflammatory process...
  35. pmc Muscle oxidative capacity during IL-6-dependent cancer cachexia
    James P White
    Dept of Exercise Science, University of South Carolina, Public Health Research Center, Rm 405, 921 Assembly St, Columbia, SC 29208, USA
    Am J Physiol Regul Integr Comp Physiol 300:R201-11. 2011
    ..between muscle oxidative capacity and muscle mass loss in red and white hindlimb muscles during cancer cachexia development in the Apc(Min/+) mouse...
  36. ncbi Molecular pathways leading to cancer cachexia
    Michael J Tisdale
    Cancer Biochemistry, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
    Physiology (Bethesda) 20:340-8. 2005
    ..Recent studies have suggested that both tumor and host factors play a major role in tissue catabolism in cachexia, leading to upregulation of degradative pathways in both skeletal muscle and adipose tissue.
  37. ncbi Signaling pathways perturbing muscle mass
    David J Glass
    Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
    Curr Opin Clin Nutr Metab Care 13:225-9. 2010
    To discuss the mechanisms of muscle loss during cachexia.
  38. ncbi Treatment of cachexia with ghrelin in patients with COPD
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Chest 128:1187-93. 2005
    ..We investigated whether ghrelin improves cachexia and functional capacity in patients with COPD.
  39. ncbi Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice
    Kate T Murphy
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 301:R716-26. 2011
    Cancer cachexia describes the progressive skeletal muscle wasting and weakness in many cancer patients and accounts for >20% of cancer-related deaths...
  40. ncbi The experience of cancer cachexia: a qualitative study of advanced cancer patients and their family members
    Joanne Reid
    Unit of Nursing and Midwifery Research, Queen s University Belfast Belfast Health and Social Care Trust, Lisburn Road, Belfast, UK
    Int J Nurs Stud 46:606-16. 2009
    b>Cachexia in advanced malignancy is a debilitating syndrome which contributes to approximately two million deaths worldwide annually...
  41. ncbi Pre-cachexia in patients with stages I-III non-small cell lung cancer: systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system
    C M Op den Kamp
    Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Lung Cancer 76:112-7. 2012
    b>Cachexia is a prevalent phenomenon of non-small cell lung cancer (NSCLC) which is responsible for increased mortality and deterioration of physical performance...
  42. ncbi Understanding the mechanisms and treatment options in cancer cachexia
    Kenneth Fearon
    Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Nat Rev Clin Oncol 10:90-9. 2013
    Cancer cachexia is a metabolic syndrome that can be present even in the absence of weight loss ('precachexia'). Cachexia is often compounded by pre-existing muscle loss, and is exacerbated by cancer therapy...
  43. pmc Myostatin is a novel tumoral factor that induces cancer cachexia
    Sudarsanareddy Lokireddy
    School of Biological Sciences, Nanyang Technological University, Singapore
    Biochem J 446:23-36. 2012
    ..is a lack of information regarding the tumoral factors that contribute to the atrophy of muscle during cancer cachexia. Therefore, in the present study, we have characterized the secretome of C26 colon cancer cells to identify the ..
  44. pmc NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo
    Ashley Wysong
    Duke University School of Medicine, Durham, North Carolina, USA
    Am J Pathol 178:1059-68. 2011
    Cancer cachexia is a severe wasting syndrome characterized by the progressive loss of lean body mass and systemic inflammation...
  45. ncbi Cachexia assessment tools
    David Blum
    European Palliative Reasearch Center, Department of Cancer Research and Molecular Medicine, NTNU, Faculty of Medicine, Trondheim, Norway
    Curr Opin Support Palliat Care 5:350-5. 2011
    b>Cachexia is a common negative consequence of cancer and is often unrecognized. To assess cachexia, malnutrition assessment tools are used...
  46. ncbi Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactions
    Peter G Arthur
    School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Australia
    Curr Opin Clin Nutr Metab Care 11:408-16. 2008
    ..Understanding these interactions in vivo will assist in identifying opportunities for more targeted therapies to reduce skeletal muscle wasting...
  47. ncbi Both oxidative and nitrosative stress are associated with muscle wasting in tumour-bearing rats
    Esther Barreiro
    Muscle and Respiratory System Research Unit, IMIM and CEXS, Universitat Pompeu Fabra, Barcelona, Spain
    FEBS Lett 579:1646-52. 2005
    Reactive oxygen and nitrogen species (ROS and RNS) have been proposed as mechanisms of cancer-induced cachexia. In this study, we assessed using Western blot analysis the levels of total protein carbonylation (2,4-dinitrophenylhydrazine ..
  48. ncbi Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies
    Shontelle Dodson
    GTx, Inc, Memphis, Tennessee 38103 2802, USA
    Annu Rev Med 62:265-79. 2011
    Cancer cachexia is a complex metabolic condition characterized by loss of skeletal muscle...
  49. pmc Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia
    J E Belizario
    Department of Pharmacology of Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, 05508 900, Brazil
    Br J Cancer 84:1135-40. 2001
    A prominent feature of several type of cancer is cachexia. This syndrome causes a marked loss of lean body mass and muscle wasting, and appears to be mediated by cytokines and tumour products...
  50. ncbi Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice
    Michelle L Asp
    Department of Human Nutrition, College of Education and Human Ecology, The Ohio State University, Columbus, Ohio, USA
    Int J Cancer 126:756-63. 2010
    Cancer cachexia is a syndrome of unintentional weight loss that is characterized by wasting of both skeletal muscle and adipose tissue. Glucose intolerance and insulin resistance have been associated with cancer cachexia...
  51. ncbi Steep elevation of blood interleukin-6 (IL-6) associated only with late stages of cachexia in cancer patients
    Satoru Iwase
    Department of Palliative Medicine, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur Cytokine Netw 15:312-6. 2004
    ..cytokines of 28, consenting, terminally ill cancer patients were studied to determine a relationship between cachexia and changes in cytokine levels...
  52. ncbi Daily physical-rest activities in relation to nutritional state, metabolism, and quality of life in cancer patients with progressive cachexia
    Marita Fouladiun
    Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Clin Cancer Res 13:6379-85. 2007
    ..To evaluate daily physical-rest activities in cancer patients losing weight in relation to disease progression...
  53. ncbi Cachexia: prevalence and impact in medicine
    Benjamin H L Tan
    Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Curr Opin Clin Nutr Metab Care 11:400-7. 2008
    b>Cachexia is a progressive deterioration of body habitus associated with certain chronic diseases (e.g., cancer, chronic obstructive pulmonary disease, chronic heart failure, and chronic kidney disease)...
  54. ncbi Inflammation and cachexia in chronic kidney disease
    Wai W Cheung
    Division of Pediatrics Nephrology, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093 0634, USA
    Pediatr Nephrol 25:711-24. 2010
    Chronic inflammation is associated with cachexia and increased mortality risk in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Inflammation suppresses appetite and causes the loss of protein stores...
  55. pmc Interleukin 6 as a key regulator of muscle mass during cachexia
    James A Carson
    Division of Applied Physiology, Department of Exercise Science, Integrative Muscle Biology Lab, University of South Carolina, Columbia, SC 29208, USA
    Exerc Sport Sci Rev 38:168-76. 2010
    Interleukin 6 (IL-6) has received significant attention for its regulatory role in muscle wasting during cachexia. This review examines the role of circulating IL-6 for decreasing muscle mass during cancer and emphasizes some of the ..
  56. ncbi Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice
    Wai W Cheung
    Department of Pediatric, University of California at San Diego, 9500 Gilman Drive, MC 0634, La Jolla, CA 92093 0634, USA
    J Am Soc Nephrol 18:2517-24. 2007
    ..that genetic or pharmacological blockade of the melanocortin-4 receptor (MC4-R) attenuates uremia-associated cachexia. However, the potential clinical utility of this approach has been limited by the need to deliver a peptide MC4-R ..
  57. ncbi Can progressive resistance training reverse cachexia in patients with rheumatoid arthritis? Results of a pilot study
    Samuele M Marcora
    School of Sport, Health and Exercise Sciences, University of Wales Bangor, and Department of Rheumatology, Gwynedd Hospital, Bangor, Wales, UK
    J Rheumatol 32:1031-9. 2005
    A Phase II trial was performed as a preliminary test of the efficacy and safety of progressive resistance training (PRT) as adjunct treatment for rheumatoid cachexia.
  58. ncbi Cachexia worsens prognosis in patients with resectable pancreatic cancer
    Jeannine Bachmann
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    J Gastrointest Surg 12:1193-201. 2008
    ..Remarkably, there are only a few data available on the impact of cachexia in patients with pancreatic cancer scheduled for tumor resection.
  59. ncbi Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stress
    Maria Cristina C Gomes-Marcondes
    Department of Physiology and Biophysics, University of Campinas, UNICAMP, SP Brazil
    Cancer Lett 180:69-74. 2002
    Muscle wasting in cancer cachexia is associated with increased levels of malondialdehyde (MDA) in gastrocnemius muscles, suggesting an increased oxidative stress...
  60. ncbi Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis
    Kenneth C Fearon
    Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
    Am J Clin Nutr 83:1345-50. 2006
    Cancer cachexia is a multifactorial syndrome that is poorly defined.
  61. pmc Role of leptin and melanocortin signaling in uremia-associated cachexia
    Wai Cheung
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 115:1659-65. 2005
    The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-associated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 (MC4-R)...
  62. ncbi Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia
    Margaret E Benny Klimek
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem Biophys Res Commun 391:1548-54. 2010
    b>Cachexia, progressive loss of fat and muscle mass despite adequate nutrition, is a devastating complication of cancer associated with poor quality of life and increased mortality. Myostatin is a potent tonic muscle growth inhibitor...
  63. ncbi The role of cytokines in cancer cachexia
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Curr Opin Support Palliat Care 3:263-8. 2009
    ..The present investigation is devoted to uncovering the different signaling pathways - particularly transcriptional factors - involved in muscle wasting...
  64. ncbi Cancer cachexia: developing multimodal therapy for a multidimensional problem
    K C H Fearon
    Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh, United Kingdom
    Eur J Cancer 44:1124-32. 2008
    Cancer cachexia is a multi-factorial syndrome that encompasses a spectrum from early weight loss (pre-cachexia) to a state of severe incapacity incompatible with life...
  65. ncbi Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease
    Takefumi Itoh
    Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Respir Crit Care Med 170:879-82. 2004
    ..In conclusion, plasma ghrelin was elevated in underweight patients with chronic obstructive pulmonary disease, and the level was associated with a cachectic state and abnormality of pulmonary function...
  66. ncbi Cardiac cachexia: a systematic overview
    Stephan von Haehling
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Pharmacol Ther 121:227-52. 2009
    Cardiac cachexia as a terminal stage of chronic heart failure carries a poor prognosis. The definition of this clinical syndrome has been a matter of debate in recent years...
  67. pmc Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia
    Chen Bing
    Neuroendocrine and Obesity Biology Unit, Department of Medicine, University Clinical Departments, University of Liverpool, Liverpool L69 3GA, UK
    Proc Natl Acad Sci U S A 101:2500-5. 2004
    ..human malignant tumors and acts as a lipid-mobilizing factor to stimulate lipolysis in adipocytes leading to cachexia in mice implanted with ZAG-producing tumors...
  68. ncbi The causes and consequences of cancer-associated malnutrition
    Eric Van Cutsem
    Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Oncol Nurs 9:S51-63. 2005
    ..such as pro-inflammatory cytokines and hormones, have been implicated in the pathogenesis of malnutrition and cachexia. The consequences of malnutrition include impairment of immune functions, performance status, muscle function, ..
  69. ncbi Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancer
    L P Hale
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 7:846-53. 2001
    ..ZAG was recently shown to stimulate lipolysis in adipocytes, leading to the development of cachexia in animals with ZAG-producing tumors...
  70. ncbi Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress
    Giovanni Mantovani
    Department of Medical Oncology, Policlinico Universitario, University of Cagliari, Strada Statale 554 bivio Sestu, 09042 Monserrato, Italy
    J Mol Med (Berl) 81:664-73. 2003
    This study assessed in a wide population of advanced cancer patients the biological parameters relevant to cancer cachexia, such as serum levels of proinflammatory cytokines (IL-1beta, IL-6, TNFalpha), IL-2, acute-phase proteins (C-..
  71. ncbi Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Suita, Osaka, Japan
    Circulation 104:1430-5. 2001
    ..We investigated whether ghrelin improves left ventricular (LV) dysfunction and attenuates cardiac cachexia in rats with chronic heart failure (CHF).
  72. ncbi Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia
    Swarnali Acharyya
    Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Cell 8:421-32. 2005
    b>Cachexia contributes to nearly a third of all cancer deaths, yet the mechanisms underlying skeletal muscle wasting in this syndrome remain poorly defined...
  73. pmc Pathophysiological role of hormones and cytokines in cancer cachexia
    Hyun Jung Kim
    Division of Hematology and Oncology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea
    J Korean Med Sci 27:128-34. 2012
    ..In total, 21 patients were included in the cachexia group and the others served as a comparison group...
  74. ncbi Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing rats
    Carina de Lima
    Department of Physiology, Biological Science Building, Federal University of Parana, Curitiba, PR, Brazil
    Eur J Appl Physiol 104:957-64. 2008
    Here, we investigated the effect of jump exercise on tumor growth, cancer cachexia, lymphocyte proliferation and macrophage function in Walker 256 tumor-bearing rats...
  75. ncbi Regulation of lipolysis: natriuretic peptides and the development of cachexia
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, UK
    Int J Cardiol 85:125-32. 2002
    The development of cachexia is commonly seen in many pathological states and is associated with a markedly impaired prognosis. Loss of fat tissue appears to be of particular pathophysiological importance in this setting...
  76. ncbi Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factors
    M L Batista
    Laboratory of Adipose Tissue Biology, Center for Integrated Biotechnology, University of Mogi das Cruzes, Mogi das Cruzes, Sao Paulo, Brazil
    Cytokine 57:9-16. 2012
    Cancer cachexia is a multifaceted syndrome whose aetiology is extremely complex and is directly related to poor patient prognosis and survival...
  77. ncbi Are inflammatory cytokines the common link between cancer-associated cachexia and depression?
    James Illman
    Centocor, Inc, Malvern, Pennsylvania, USA
    J Support Oncol 3:37-50. 2005
    ..Cancer-related depression often occurs in association with anorexia and cachexia, although until recently the relationship between these conditions has not been well understood...
  78. ncbi Lipid mobilization in cachexia: mechanisms and mediators
    Chen Bing
    Department of Obesity and Endocrinology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
    Curr Opin Support Palliat Care 5:356-60. 2011
    Extensive loss of body fat is considered as a hallmark of cancer cachexia which affects the quality of life and shortens survival. Evidence suggests that increased lipid mobilization has a central role in adipose tissue wasting...
  79. pmc Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia
    Melissa J Puppa
    Department of Exercise Science, University of South Carolina, Columbia, SC 29208, USA
    Biochim Biophys Acta 1812:1601-6. 2011
    The Apc(Min/+) mouse, an animal model of colorectal cancer and cachexia, has a heterologous mutation in the Apc tumor suppressor gene, predisposing the mouse to intestinal and colon tumor development...
  80. ncbi Cancer anorexia-cachexia syndrome: psychological effect on the patient and family
    Susan McClement
    Faculty of Nursing, University of Manitoba, Research Associate, Winnipeg, Manitoba, Canada
    J Wound Ostomy Continence Nurs 32:264-8. 2005
    ..Chronic nausea and early satiety may also occur. This constellation of symptoms is known as the cancer anorexia-cachexia syndrome...
  81. pmc Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia
    R A Murphy
    Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, 4 126 Li Ka Shing Center, Edmonton, AB T6G 2E1, Canada
    Br J Cancer 105:1469-73. 2011
    Cancer cachexia is characterised by a progressive loss of muscle, resulting in functional impairment and shorter survival...
  82. ncbi Adipocytokines and squamous cell carcinoma of the esophagus
    Takako Eguchi Nakajima
    Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    J Cancer Res Clin Oncol 136:261-6. 2010
    ..that the impaired response of adipocytokines to body weight loss may play a role in the pathogenesis of cancer-induced cachexia. We investigated the association between adipocytokines with squamous cell carcinoma of the esophagus (SCCE).
  83. ncbi Cachexia, malnutrition, the refeeding syndrome, and lessons from Goldilocks
    J Alexander Palesty
    Department of Surgery, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
    Surg Clin North Am 91:653-73. 2011
    b>Cachexia has plagued clinicians for centuries. Although all cachexia is related to malnutrition, cachexia associated with malignant diseases differs from starvation cachexia in that it is more recalcitrant to nutritional therapy...
  84. ncbi What is cancer anorexia-cachexia syndrome? A historical perspective
    N Bennani-Baiti
    Section of Palliative Medicine and Supportive Oncology, The Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    J R Coll Physicians Edinb 39:257-62. 2009
    Cancer anorexia-cachexia syndrome (CACS) is a lethal but poorly defined involuntary wasting disorder. Loss of skeletal muscle and fat distinguishes it from starvation...
  85. ncbi Central tenet of cancer cachexia therapy: do patients with advanced cancer have exploitable anabolic potential?
    Carla M Prado
    Department of Nutrition, Food and Exercise Sciences, The Florida State University, Tallahassee, FL
    Am J Clin Nutr 98:1012-9. 2013
    Skeletal muscle wasting is considered the central feature of cachexia, but the potential for skeletal muscle anabolism in patients with advanced cancer is unproven.
  86. ncbi Characterization of a cancer cachectic factor
    P Todorov
    CRC Nutritional Biochemistry Research Group, Pharmaceutical Sciences Institute, Aston University, Birmingham UK
    Nature 379:739-42. 1996
    Cancer cachexia is a syndrome of progressive wasting which has been suggested to be mediated by tumour-necrosis factor-alpha, interleukins 1 and 6, interferon-gamma and leukaemia-inhibitory factor...
  87. ncbi Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexia
    David R Thomas
    Division of Geriatric Medicine, Saint Louis University Medical Center, Saint Louis, MO 63104, USA
    Clin Nutr 26:389-99. 2007
    ..Involuntary weight loss can be categorized into three primary etiologies of starvation, sarcopenia, and cachexia. Starvation results in a loss of body fat and non-fat mass due to inadequate intake of protein and energy...
  88. ncbi Cancer cachexia and targeting chronic inflammation: a unified approach to cancer treatment and palliative/supportive care
    Neil MacDonald
    McGill Cancer Nutrition and Rehabilitation Programme, McGill University, Montreal, Quebec, Canada
    J Support Oncol 5:157-62; discussion 164-6, 183. 2007
    ..Many of the same inflammatory factors that promote tumor growth also are responsible for cancer cachexia/anorexia, pain, debilitation, and shortened survival...
  89. ncbi Possible mechanisms underlying the development of cachexia in COPD
    P D Wagner
    Division of Physiology, Dept of Medicine, University of California, San Diego, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093 0623A, USA
    Eur Respir J 31:492-501. 2008
    About 25% of patients with chronic obstructive pulmonary disease (COPD) will develop cachexia (fat-free body mass index <17 kg.m(-2) (males) or <14 kg.m(-2) (females))...
  90. pmc Expression of NF-kappaB and IkappaB proteins in skeletal muscle of gastric cancer patients
    Mary G Rhoads
    Department of Health Sciences, Boston University, Boston, MA, USA
    Eur J Cancer 46:191-7. 2010
    The mechanisms eliciting cancer cachexia are not well understood. Wasting of skeletal muscle is problematic because it is responsible for the clinical deterioration in cancer patients and for the ability to tolerate cancer treatment...
  91. ncbi Interleukin 6/interleukin 6 receptor interaction and its role as a therapeutic target for treatment of cachexia and cancer
    Ulrich H Weidle
    Roche Diagnostics, Division Pharma, Im Nonnenwald 2, Penzberg, Germany
    Cancer Genomics Proteomics 7:287-302. 2010
    ..of IL6 signaling with monoclonal antibodies directed against IL6 or IL6R and their potential impact for treatment of tumor-associated cachexia and as antitumoral agents as monotherapy and in combination with small molecule compounds.
  92. ncbi Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia
    W Doehner
    Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
    Eur J Endocrinol 145:727-35. 2001
    ..This study aimed to examine the influence of leptin on GHBP in CHF patients with and without cardiac cachexia compared with healthy control subjects.
  93. ncbi Cytokines and their relationship to the symptoms and outcome of cancer
    Bostjan Seruga
    Division of Medical Oncology, Princess Margaret Hospital, St Michael s Hospital, University of Toronto, Toronto, Canada
    Nat Rev Cancer 8:887-99. 2008
    ..In people with advanced cancer, pro-inflammatory cytokines are additionally associated with anorexia and cachexia, pain, toxicity of treatment and resistance to treatment...
  94. ncbi Role of the central melanocortin system in cachexia
    D L Marks
    Department of Pediatric Endocrinology, Oregon Health Sciences University, Portland 97201, USA
    Cancer Res 61:1432-8. 2001
    ..In some cases, a devastating state of malnutrition known as cachexia arises, brought about by a synergistic combination of a dramatic decrease in appetite and an increase in ..
  95. pmc Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting
    Norleena P Gullett
    Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA
    Am J Clin Nutr 91:1143S-1147S. 2010
    ..chronic diseases, which include chronic kidney disease, cancer, and AIDS, were presented at a symposium entitled "Cachexia and Wasting: Recent Breakthroughs in Understanding and Opportunities for Intervention," held at Experimental ..
  96. pmc The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension
    C W le Roux
    Heart 91:241-2. 2005
  97. ncbi Anti-inflammatory therapies in cancer cachexia
    Josep M Argiles
    Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Eur J Pharmacol 668:S81-6. 2011
    ..and neurons, where they produce a complex cascade of biological responses leading to the wasting associated with cachexia. The cytokines that have been involved in this cachectic response are TNF-alpha, IL-1, IL-6 and interferon-gamma...
  98. ncbi Cancer cachexia: a systematic literature review of items and domains associated with involuntary weight loss in cancer
    David Blum
    Oncological Palliative Medicine, Division of Oncology Hematology, Department of Internal Medicine and Palliative Care Center, Cantonal Hospital, St Gallen, Switzerland
    Crit Rev Oncol Hematol 80:114-44. 2011
    The concept of cancer-related anorexia/cachexia is evolving as its mechanisms are better understood...
  99. ncbi Body composition and plasma levels of inflammatory biomarkers in COPD
    T M L Eagan
    Dept of Thoracic Medicine, Haukeland University Hospital, Jonas Lies vei, 5021 Bergen, Norway
    Eur Respir J 36:1027-33. 2010
    ..14 (-0.23- -0.04), whereas FFMI was unrelated to OPG. In conclusion, COPD patients with low FFMI had lower not higher plasma levels of CRP and sTNF-R1, whereas higher fat mass was associated with higher CRP and sTNF-R1 and lower OPG...
  100. ncbi Effect of eicosapentaenoic acid (EPA) on expression of a lipid mobilizing factor in adipose tissue in cancer cachexia
    S T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Prostaglandins Leukot Essent Fatty Acids 72:409-14. 2005
    Adipose tissue of mice bearing a cachexia-inducing murine tumour (MAC16) shows increased expression of zinc-alpha(2)-glycoprotein (ZAG), a lipolytic factor thought to be responsible for the increased lipolysis...
  101. pmc Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants
    M Buck
    Department of Medicine, Veterans Affairs Medical Center, San Diego, CA, USA
    EMBO J 15:1753-65. 1996
    ..The decreased body weight, muscle wasting and skeletal muscle molecular abnormalities of cachexia were prevented by treatment of TNF alpha mice with the antioxidants D-alpha-tocopherol of BW755c, or the NOS ..

Research Grants69

  1. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..MBOAT4, ghrelin-O-acyl transferase (GOAT), food intake, peripheral regulation, gastric mucosal X/A cell, obesity, cachexia, LPS BRIEF STATEMENT OF RESEARCH OBJECTIVES (Do not use continuation sheets) Chronic changes in body weight ..
  2. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..Project Summary/Abstract Every year, over 1.5 million individuals in the US are diagnosed with cancer. Cachexia, defined as an involuntary weight loss >5%, is present in up to 80% of these patients and it encompasses the ..
  3. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..In humans, states of negative energy balance as in anorexia, cachexia, and excessive exercise can all decrease gonadotropins secretion resulting in abnormal cyclicity and infertility...
  4. Nutrition and Anabolic Interventions in Cancer Cachexia
    Melinda Sheffield-Moore; Fiscal Year: 2013
    Project Summary/Abstract Cancer cachexia severely depletes skeletal muscle mass leading to impairments in physical function and a diminished quality of life. In the clinical realm, malnutrition and cachexia are synonymous...
  5. Muscle stem cell therapy in a mouse model of premature aging
    Johnny Huard; Fiscal Year: 2010
    ..Both mice develop age-related pathologies including ataxia, kyphosis, cachexia, disc degeneration, osteoporosis, incontinence, epidermal atrophy, sarcopenia, bone marrow degeneration and liver ..
  6. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..b>Cachexia in people with COPD signals a rapid downhill course...
  7. Body composition, bone structure, and joint damage in rheumatoid arthritis
    Joshua F Baker; Fiscal Year: 2013
    ..Given that 1) rheumatoid cachexia is characterized by reduced lean mass with normal or increased fat mass and 2) low lean mass is associated with ..
  8. Brain interleukin-18 control of food intake and energy expenditure
    Eric P Zorrilla; Fiscal Year: 2013
    ..Translationally, this function would make IL-18 a clinically relevant target for sickness syndrome/cachexia. Moreover, because IL-18 administration does not share "sickness syndrome" effects of the pro-inflammatory system,..
  9. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    Kevin L Grove; Fiscal Year: 2013
    ..by applicant): It is firmly established that states of energy deficiency, such as fasting, anorexia nervosa, cachexia, bulimia, lactation and exercise-induced amenorrhea, as well as states of energy overabundance, such as obesity, ..
  10. Identification of key tumor cell-released factors that induce cachexia
    Yi Ping Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cachexia, a wasting disease characterized by progressive loss of muscle with or without loss of fat mass, is frequently associated with cancer and is estimated to be the immediate cause of death in 20%..
  11. Eicosapentaenoic acid and protein modulation to induce anabolism in COPD
    MARIELLE PKJ ENGELEN; Fiscal Year: 2012
    ..altered regulation of protein metabolism, which result initially in muscle atrophy only but in later stages in cachexia. Despite the well-recognized importance of treating cachexia in COPD with appropriate nutrition, current ..
  12. Inflammatory Cytokine regulation of POMC and Orexin neurons in cachexia.
    AARON GROSSBERG; Fiscal Year: 2012
    ..This constellation of findings closely resembles cachexia, a state of disease-associated wasting common to many chronic diseases...
  13. The Molecular Basis of Muscle Wasting in Cancer Cachexia
    SUSAN KANDARIAN; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Approximately two million people die world-wide of the consequences of cancer cachexia annually...
  14. Angiotensin II, IGF-1 and Skeletal Muscle Atrophy
    Patrice Delafontaine; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cachexia is a major complication of chronic diseases such as heart failure, kidney failure and cancer. In these conditions the renin-angiotensin system (RAS) is often activated...
  15. The effects of glucose on central vagal brainstem circuits
    KIRSTEEN NAIRN BROWNING; Fiscal Year: 2013
    ..a variety of pathological conditions, including, for example, functional gastric motility disorders, obesity or cachexia. The specific mechanisms by which glucose can reorganize vagally-mediated gastrointestinal visceral reflexes are ..
  16. The Role of the Central Melanocortin System in the Muscle Wasting of Cachexia
    THEODORE PAUL BRAUN; Fiscal Year: 2013
    ..research is to understand the role of the central melanocortin system In the pathogenesis of muscle wasting in cachexia. A patient's ability to maintain lean mass is an important factor in quality of life as well as an important ..
  17. Hypothalamic Mechanisms in Cachexia
    Daniel L Marks; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cachexia, or disease-associated wasting, is a common occurrence in cancer, renal failure, and infectious disease...
  18. Targeting Adipocyte Lipases to Treat Pancreatic Cancer-Associated Cachexia
    Enrique Saez; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cachexia is a progressive atrophy of adipose tissue and skeletal muscle that occurs in more than 85% of pancreatic ductal adenocarcinoma (PDAC) patients...
  19. NO-dependent SOD3 protection against cachexia
    Zhen Yan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cachexia is a serious medical condition in many chronic diseases, such as cancer, chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), chronic kidney disease (CKD) and some ..
  20. Long lasting ghrelin derivatives for the treatment of cancer cachexia
    TARIK SOLIMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cachexia is a complex syndrome characterized by involuntary weight loss and skeletal muscle wasting that leads to fatigue, weakness and a loss of appetite that is not reversed by increased caloric ..
  21. Role of Ca2+/calmodulin kinases in skeletal muscle glucose transport and growth.
    CAROL WITCZAK; Fiscal Year: 2013
    Skeletal muscle metabolic dysfunction and atrophy are prominent features of cachexia, a complex and devastating syndrome characterized by loss of body weight, loss of skeletal muscle and fat mass, and skeletal muscle weakness...
  22. Role of Parabrachial Nucleus Neuropeptides in Feeding
    John Paul Baird; Fiscal Year: 2011
    ..RELEVANCE: Feeding and metabolic disorders such as obesity, anorexia, bulimia, failure to thrive, gastric reflux, cachexia, early satiety, delayed gastric emptying, dysgeusia, and anosmia contribute to diseases including hypertension, ..
  23. Metabolic Actions of Brain Leptin Receptors Signaling in Type 1 Diabetes
    Roberto Coppari; Fiscal Year: 2012
    ..These therapies reduce hyperglycemia, glycosylated hemoglobin, cachexia and prevent or delay some of T1D-associated morbidities...
  24. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2013
    ..and strength in patients with muscle degenerative and wasting diseases, like muscular dystrophy, sarcopenia, and cachexia, which is often seen in patients with diseases like cancer, AIDS, and sepsis...
  25. p38 MAPK a regulator of muscle contraction and function
    Zhen Yan; Fiscal Year: 2013
    ..of this extremely important signaling pathway will facilitate the development of new interventions for numerous medical conditions, such as cardiac cachexia and type 2 diabetes that are profoundly influenced by skeletal muscle function.
  26. ACTIVATORS OF MUSCLE GENES
    Helen M Blau; Fiscal Year: 2013
    ..treating skeletal muscle diseases, including genetic defects and muscle wasting conditions such as sarcopenia and cachexia. The therapeutic utility of MuSCs is limited by the rarity of these cells in adult tissues and the inability to ..
  27. Molecular Pathogenesis and Treatment of MNGIE
    Michio Hirano; Fiscal Year: 2013
    ..in childhood or early adulthood causes ptosis, ophthalmoplegia, severe gastrointestinal dysmotility leading to cachexia, peripheral neuropathy, leukoencephalopathy, and alterations of mitochondrial DNA (mtDNA)...
  28. Molecular Mechanisms that Cause Muscle Atrophy
    Alfred L Goldberg; Fiscal Year: 2012
    ..g. cancer cachexia, renal failure) and aging...
  29. RGK proteins and aging muscle
    ROGER ALAN BANNISTER; Fiscal Year: 2012
    ..in the course of this study may also contribute to a better understanding of muscle weakness associated with cachexia, diabetes and degenerative neuromuscular disease...
  30. Circadian rhythms and skeletal muscle
    KARYN ANN ESSER; Fiscal Year: 2012
    ..for maintenance of muscle with an impact on our understanding and treatment of sarcopenia, muscle wasting/cachexia and problems associated with metabolic diseases such as insulin resistance...
  31. Profiling and Characterizing Prostate Cancer Tumor Dormancy in the Bone Marrow
    ROBERT LOUIS VESSELLA; Fiscal Year: 2010
    ..and their activation can lead to the replacement of bone marrow (BM), spinal cord compression, severe bone pain, cachexia and death...
  32. TRAINING GRANT IN ACADEMIC ENDOCRINOLOGY
    PHILIP REED LARSEN; Fiscal Year: 2013
    ..particularly in the hypothalamus, the control of skeletal muscle repair and mechanisms of muscle proteolysis in cachexia and muscle atrophy, the mechanisms of steroid hormone action and the epidemiology of diabetes, obesity, and ..
  33. Role of neuropeptide Y-glucose inhibited (NPY-GI) neurons in cytokine-induced ano
    Vanessa H Routh; Fiscal Year: 2010
    Anorexia-cachexia occurs because detection of energy deficit by the brain becomes impaired due to cytokine excess...
  34. Acute Lung Injury Induces Skeletal Muscle Atrophy
    Daniel Clark Files; Fiscal Year: 2010
    ..will also investigate whether the apparent suppression of appetite in these animals is indicative of a state of cachexia and how this state may alter muscle wasting and impair the recovery process...
  35. Calcineurin signaling, PGC-1 alpha and protein-energy wasting in kidney disease
    S Russ Price; Fiscal Year: 2013
    ..peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) is decreased during CKD and other cachexia-inducing conditions...
  36. Mechanisms underlying myostatin regulation and activity
    Se Jin Lee; Fiscal Year: 2013
    ..states characterized by debilitating muscle loss, including muscle degenerative diseases, neuromuscular diseases, cachexia, and age-related sarcopenia...
  37. A photographic method for human body composition assessment
    HELEN OLIVIA AFFUSO; Fiscal Year: 2013
    ..including obesity and sarcopenia, whose very definitions depend on assessment of fat and fat free mass, but also cachexia induced by HIV, cancer, and other diseases;multiple sclerosis;wasting in neurological disorders such as Parkinson&..
  38. PET/CT of skeletal muscle amino acid kinetics
    Thomas F Lang; Fiscal Year: 2013
    ..of conditions such as Type 2 Diabetes, protease inhibitor therapy for HIV, chronic kidney disease and cancer cachexia. Clinical research studies investigating the pathophysiology and treatment of muscle loss often utilize CT and ..
  39. Characterization of the Insulin to Autophagy Pathway in Muscles
    Norbert Perrimon; Fiscal Year: 2013
    ..signaling and the basic cellular machinery involved in protein degradation, we expect that our studies will be directly relevant to the understanding of muscle wasting associated with muscular dystrophies, cachexia and sarcopenia.
  40. Pre-Clinical and Clinical Evaluation of Skeletal Muscle Activator, CK-2017357 for
    MALAR PANNIRSELVAM; Fiscal Year: 2012
    ..intermittent claudication (cramping pains in the legs caused by peripheral arterial disease), muscle wasting (cachexia) associated with cancer, heart failure or other diseases, and the frailty associated with aging (also known as ..
  41. Leica Laser Microdissection Microscope for a Shared Resource
    Martha L Campbell-Thompson; Fiscal Year: 2013
    ..inflammatory response syndromes and to chronic inflammatory processes, including cancer and AIDS-associated cachexia. He too has active NIH funding for studies with laser capture microdissection for arterial venous fistula...
  42. Melanocortin Ligands in Disease Cachexia
    KENNETH ALLEN GRUBER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cachexia-anorexia syndrome is a life-threatening aspect to many diseases, in particular many forms of cancer or therapies for cancer...
  43. Long-acting Growth Hormone for Treating HIV-Associated Adipose Redistribution Syn
    George Cox; Fiscal Year: 2009
    ..GH analog for the treatment of HARS and other metabolic complications of HIV and HIV therapies such as wasting (cachexia)...
  44. Dissection of a Developmental Checkpoint That Preserves Regenerative Capacity
    ADRIAN J HALME; Fiscal Year: 2013
    ..damage and inflammation can produce systemic effects on growth and endocrine control of development, which are each observed in clinical examples of persistent inflammation such as obesity-related insulin resistance and cancer cachexia.
  45. Isoform-specific roles of the Na,K-ATPase in skeletal muscle
    Jerry B Lingrel; Fiscal Year: 2013
    ..Skeletal muscle weakness and fatigue is a common, debilitating condition in heart failure, sarcopenia, cachexia, muscular dystrophies, COPD, and other disorders...
  46. Chemical probes that target Stat3 to treat cancer
    DAVID JOHN TWEARDY; Fiscal Year: 2013
    ..murine bone marrow colony formation in vitro, and, prevented weight loss and sarcopenia in a murine model of cachexia. The specific hypothesis that will be examined in this Phase I STTR is that C188-9 or one of its derivatives will ..
  47. Manipulation of STAT3 Signaling for Muscle Preservation in Cancer Cachexia
    Teresa A Zimmers; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cachexia, or progressive wasting of fat and skeletal muscle despite adequate nutrition, is a devastating complication of cancer...
  48. Ubiquitin-like Protein Transfer Cascades
    Brenda A Schulman; Fiscal Year: 2013
    ..with diseases, including cancers, developmental disorders, high blood pressure, neurodegenerative disorders, and cachexia. We propose to extend our expertise on UBL conjugation to the two largest E3 families: RING (Really Interesting ..
  49. Carbohydrate Appetite, Fat Appetite and Obesity
    Anthony Sclafani; Fiscal Year: 2013
    ..This knowledge may also be applied to promote eating in clinical cases of anorexia and cachexia.
  50. PQ6 MECHANISMS OF CACHEXIA LIKE WASTING IN A DROSPHILA CANCER MODEL
    David Bilder; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cancer cachexia, a wasting syndrome characterized by the dramatic loss of skeletal muscle and adipose tissue, is perhaps the most poorly understood feature of cancer pathophysiology...
  51. Myostatin Family Signaling in Burn-Injury Related Muscle Wasting
    Teresa A Zimmers; Fiscal Year: 2013
    ..However, persistent cachexia in the convalescent phase is pathological in itself...
  52. Genetic modification of aging and diseased striated muscle
    Jeffrey S Chamberlain; Fiscal Year: 2013
    ..wasting disorders, such as muscle loss during aging (sarcopenia) and muscle atrophy associated with cancer (cachexia). Our primary focus will be on aging normal and mdx mice, a model for DMD/BMD...
  53. A comparative approach to evaluate muscle growth in an indeterminate growth model
    Peggy R Biga; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Project Summary Muscle wasting syndrome and cachexia are associated with many degenerative diseases, like cancer, AIDS, and other systemic diseases...
  54. Ghrelin and Strength Training in Frail Elderly
    Anne R Cappola; Fiscal Year: 2012
    ..It has been studied in over 300 humans, including those with specific diseases that cause cachexia (e.g. renal failure, cancer), but not in frail individuals...
  55. A20 (TNFAIP3) Regulation of Intestinal Immune Homeostasis
    TIMOTHY THEN CHIOH LU; Fiscal Year: 2012
    ..develop spontaneous intestinal inflammation and die perinatally due to spontaneous systemic inflammation and cachexia. Recent genetic studies have identified TNFAIP3 as a candidate gene associated with inflammatory bowel disease...
  56. The PRESS ERA: Protein &Resistance Exercise Supplement Study for Elderly with RA
    Rebecca Manno; Fiscal Year: 2013
    ..combination of exercise and nutritional interventions have been suggested as important treatments for rheumatoid cachexia and older frail individuals in general...
  57. Role of Merg1, a K+ Channel in the Onset of Skeletal Muscle Atrophy
    Amber L Pond; Fiscal Year: 2011
    ..Relevance. Skeletal muscle atrophy occurs with many pathological conditions (e.g., AIDS, diabetes, cancer cachexia, etc.) and is related to increased disability, morbidity and mortality...
  58. CYCLOPENTANNELATION IN TOTAL SYNTHESIS
    MARCUS ANTONIUS TIUS; Fiscal Year: 2010
    ..In tumor cells IL-6 stimulates cell proliferation and is also associated with cachexia. Selective inhibition of IL-6 could offer a new treatment for cancer...
  59. A Proteomic Screen for Muscle E3 LigaseSubstrates in Cachexia.
    IRMA SANCHEZ; Fiscal Year: 2012
    ..aspect of cancer has proven enigmatic, as the molecular details of the protein degradation programs underlying cachexia have not been elucidated...
  60. Parabrachial-Forebrain Interactions in Conditioned Taste Aversion
    STEPHEN REILLY; Fiscal Year: 2013
    ..For instance, cancer patients oftentimes develop strong aversions to their diets (leading to anorexia and cachexia) because the aversive visceral side effects of chemotherapy are associated with the foods consumed before ..
  61. Parabrachial-Forebrain Interactions in Conditioned Taste Aversion
    STEPHEN REILLY; Fiscal Year: 2009
    ..For instance, cancer patients oftentimes develop strong aversions to their diets (leading to anorexia and cachexia) because the aversive visceral side effects of chemotherapy are associated with the foods consumed before ..
  62. Molecular Imaging of Cancer Cachexia
    Zaver M Bhujwalla; Fiscal Year: 2010
    One of the most under explored and yet devastating consequences of cancer is cachexia, a condition in which the body is consumed by deranged carbohydrate, lipid and protein metabolism induced by inflammatory cytokines secreted ..
  63. MEGESTROL ACETATE FOR TREATMENT OF CANCER CACHEXIA
    David Heber; Fiscal Year: 1992
    ..These studies should provide critical information in understanding the action of this promising new approach to this important clinical problem...
  64. RECYCLING OF UREA NITROGEN IN CANCER CACHEXIA
    Bruce Patterson; Fiscal Year: 1999
    ..Urea N recycling has not thus far been examined in the protein catabolic state associated with cancer cachexia, a condition characterized by progressive muscle protein loss resulting from altered protein metabolism, chronic ..
  65. Interleukin-6 Expression and Function in Adipose Cells
    Jianbei Deng; Fiscal Year: 2006
    Elevated interleukin-6 (IL-6) is associated with fat wasting in systemic infection and cancer cachexia. However, important new data indicates that circulating IL-6 is also elevated in human obesity, and adipose tissue is the principal ..
  66. HUMAN LYMPHOCYTE PRODUCTION OF TUMOR NECROSIS FACTOR
    Sun Sang Sung; Fiscal Year: 1993
    ..necrosis factor (TNF) is important in inducing a number of abnormal physiological conditions such as shock and cachexia. In the immune system, it promotes B and T cell proliferation, inhibits the colony formation of hematopoietic ..
  67. Role of IL-4 During Acute Schistosomiasis
    Elisabeth Patton; Fiscal Year: 2002
    ..mansoni infection. These animals are unable to mount a Th2 response and suffer from debilitating cachexia and enhanced mortality subsequent to the onset of egg production...
  68. Liver Derived Microparticles In Cirhossis Pathogenesis
    RAFAL WITEK; Fiscal Year: 2009
    ..contribute to the multiple, extra-hepatic manifestations of cirrhosis, including cutaneous spider telangectases, cachexia, increased intestinal permeability, ascites and the hepatorenal syndrome, the portopulmonary syndrome, and ..
  69. ALCOHOL, NUTRITION, AND IMMUNOMODULATION
    Craig McClain; Fiscal Year: 2000
    ..are great similarities between the metabolic abnormalities/complications of AIDS and ALD including anorexia, cachexia, immune suppression, hypoalbuminemia, increased acute phase reactants and edema, to name only a few...