Genomes and Genes
Summary: General ill health, malnutrition, and weight loss, usually associated with chronic disease.
Publications330 found, 100 shown here
- Cachexia: pathophysiology and clinical relevanceJohn E Morley
Division of Geriatric Medicine, Saint Louis University School of Medicine, 1042 South Grand Boulevard M238, St Louis, MO 63104, USA
Am J Clin Nutr 83:735-43. 2006b>Cachexia causes weight loss and increased mortality. It affects more than 5 million persons in the United States. Other causes of weight loss include anorexia, sarcopenia, and dehydration...
- Cachexia: a new definitionWilliam J Evans
Donald W Reynolds Institute on Aging, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 806, Little Rock, AR 72205, USA
Clin Nutr 27:793-9. 2008On December 13th and 14th a group of scientists and clinicians met in Washington, DC, for the cachexia consensus conference. At the present time, there is no widely agreed upon operational definition of cachexia...
- Mechanisms of cancer cachexiaMichael J Tisdale
Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
Physiol Rev 89:381-410. 2009Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a shortened survival time...
- Definition and classification of cancer cachexia: an international consensusKenneth Fearon
Clinical and Surgical Sciences, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh, UK
Lancet Oncol 12:489-95. 2011To develop a framework for the definition and classification of cancer cachexia a panel of experts participated in a formal consensus process, including focus groups and two Delphi rounds...
- Cancer cachexia: mediators, signaling, and metabolic pathwaysKenneth C H Fearon
Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh EH16 4SA, UK
Cell Metab 16:153-66. 2012Cancer cachexia is characterized by a significant reduction in body weight resulting predominantly from loss of adipose tissue and skeletal muscle...
- IKKbeta/NF-kappaB activation causes severe muscle wasting in miceDongsheng Cai
Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Cell 119:285-98. 2004Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and immobilization...
- Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survivalXiaolan Zhou
Departments of Metabolic Disorders and Protein Science, Amgen Research, Thousand Oaks, CA 91320, USA
Cell 142:531-43. 2010Muscle wasting and cachexia have long been postulated to be key determinants of cancer-related death, but there has been no direct experimental evidence to substantiate this hypothesis...
- Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics"M Muscaritoli
Department of Clinical Medicine, La Sapienza, University of Rome, Viale dell Universita, 37, Rome 00185, Italy
Clin Nutr 29:154-9. 2010..Based on these premises, the Special Interest Group (SIG) on cachexia-anorexia in chronic wasting diseases was created within ESPEN with the aim of developing and spreading the ..
- Adipose triglyceride lipase contributes to cancer-associated cachexiaSuman K Das
Institute of Pathology, Medical University of Graz, Graz, Austria
Science 333:233-8. 2011b>Cachexia is a multifactorial wasting syndrome most common in patients with cancer that is characterized by the uncontrolled loss of adipose and muscle mass...
- Cachexia in cancer patientsMichael J Tisdale
Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
Nat Rev Cancer 2:862-71. 2002
- Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophySarah A Reed
Department of Physical Therapy, 101 S Newell Dr, University of Florida, Gainesville, FL 32611, USA
FASEB J 26:987-1000. 2012b>Cachexia is characterized by inexorable muscle wasting that significantly affects patient prognosis and increases mortality. Therefore, understanding the molecular basis of this muscle wasting is of significant importance...
- PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in miceTuoyu Geng
Department of Medicine Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22908, USA
Am J Pathol 178:1738-48. 2011..These findings suggest that PGC-1α protects muscle from catabolic wasting in chronic heart failure through enhanced nitric oxide antioxidant defenses and inhibition of the forkhead transcription factor signaling pathways...
- Skeletal muscle loss: cachexia, sarcopenia, and inactivityWilliam J Evans
Division of Geriatrics, Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
Am J Clin Nutr 91:1123S-1127S. 2010Loss of skeletal muscle mass occurs during aging (sarcopenia), disease (cachexia), or inactivity (atrophy). This article contrasts and compares the metabolic causes of loss of muscle resulting from these conditions...
- STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexiaAndrea Bonetto
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
PLoS ONE 6:e22538. 2011b>Cachexia, or weight loss despite adequate nutrition, significantly impairs quality of life and response to therapy in cancer patients...
- Wasting as independent risk factor for mortality in chronic heart failureS D Anker
Department of Cardiac Medicine, National Heart and Lung Institute, London
Lancet 349:1050-3. 1997..Wasting in chronic heart failure (CHF) has long been known but is little investigated. We sought to find out whether the cachectic state in CHF provides additional prognostic information about all-cause mortality...
- Induction of cachexia in mice by systemically administered myostatinTeresa A Zimmers
Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
Science 296:1486-8. 2002..of myostatin in adult mice was found to induce profound muscle and fat loss analogous to that seen in human cachexia syndromes...
- JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexiaAndrea Bonetto
Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Am J Physiol Endocrinol Metab 303:E410-21. 2012b>Cachexia, the metabolic dysregulation leading to sustained loss of muscle and adipose tissue, is a devastating complication of cancer and other chronic diseases...
- Nerve growth factor links oral cancer progression, pain, and cachexiaYi Ye
Bluestone Center for Clinical Research, New York University College of Dentistry, 421 First Avenue, 233W, New York, NY 10010, USA
Mol Cancer Ther 10:1667-76. 2011..Cancer-induced pain and cachexia are often studied and treated independently, although both symptoms are strongly linked with chronic inflammation ..
- The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in miceSergio Di Marco
Department of Biochemistry, Rosalind and Morris Goodman Cancer Center, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada
Nat Commun 3:896. 2012b>Cachexia, or muscle-wasting syndrome, is one of the major causes of death in patients affected by diseases such as cancer, AIDS and sepsis. However, no effective anti-cachectic treatment is currently available...
- Cancer cachexia--pathophysiology and managementHajime Suzuki
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
J Gastroenterol 48:574-94. 2013About half of all cancer patients show a syndrome of cachexia, characterized by anorexia and loss of adipose tissue and skeletal muscle mass...
- A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiencyG A Taylor
Howard Hughes Medical Institute Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
Immunity 4:445-54. 1996..normal at birth, but soon manifested marked medullary and extramedullary myeloid hyperplasia associated with cachexia, erosive arthritis, dermatitis, conjunctivitis, glomerular mesangial thickening, and high titers of anti-DNA and ..
- The role of C-reactive protein as a prognostic indicator in advanced cancerFade Aziz Mahmoud
Taussig Cancer Center, The Cleveland Clinic Foundation, M76, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Curr Oncol Rep 4:250-5. 2002..It is positively correlated with weight loss, anorexia-cachexia syndrome, extent of disease, and recurrence in advanced cancer...
- Systemic inflammation, nutritional status and survival in patients with cancerDonald C McMillan
University Department of Surgery, Faculty of Medicine University of Glasgow, Royal Infirmary, Glasgow, UK
Curr Opin Clin Nutr Metab Care 12:223-6. 2009..good evidence in humans that a chronic systemic inflammatory response results in the cardinal features of cancer cachexia, principally the progressive loss of weight (in particular lean tissue)...
- An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancerDonald C McMillan
University Dept of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
Proc Nutr Soc 67:257-62. 2008..The aetiology of such weight loss or cachexia is complex and involves both tumour and host responses...
- Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatmentNagi B Kumar
Department of Population Sciences, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612, USA
Curr Treat Options Oncol 11:107-17. 2010The complex syndrome of cancer cachexia (CC) that occurs in 50% to 80% cancer patients has been identified as an independent predictor of shorter survival and increased risk of treatment failure and toxicity, contributing to the mortality ..
- Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass indexLisa Martin
University of Alberta, Edmonton, Alberta, Canada
J Clin Oncol 31:1539-47. 2013..Emerging evidence suggests muscle depletion predicts survival of patients with cancer...
- Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexiaP Costelli
Dipartimento di Medicina ed Oncologia Sperimentale, Sezione di Patologia Generale, , Italy
Br J Cancer 84:946-50. 2001b>Cachexia is a syndrome characterized by profound tissue wasting that frequently complicates malignancies...
- Systemic inflammation, cachexia and prognosis in patients with cancerChristopher Deans
Tissue Injury and Repair Group, MRC Centre for Inflammation Research, Department of Clinical and Surgical Sciences, Medical School, Edinburgh University, Scotland, UK
Curr Opin Clin Nutr Metab Care 8:265-9. 2005b>Cachexia remains an important cause of morbidity and mortality among cancer patients. The mechanisms underlying this syndrome remain unclear and are almost certainly multifactorial...
- The mechanisms of cachexia underlying muscle dysfunction in COPDA H V Remels
NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
J Appl Physiol (1985) 114:1253-62. 2013Pulmonary cachexia is a prevalent, debilitating, and well-recognized feature of COPD associated with increased mortality and loss of peripheral and respiratory muscle function...
- Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib ± megestrol acetate for patients with cancer-related anorexia/cachexia syndromeClelia Madeddu
Department of Medical Oncology, University of Cagliari, Cagliari, Italy
Clin Nutr 31:176-82. 2012..e. antioxidants) with carnitine + celecoxib ± megestrol acetate for the treatment of cancer-related anorexia/cachexia syndrome (CACS): the primary endpoints were increase of lean body mass (LBM) and improvement of total daily ..
- A randomized phase III clinical trial of a combined treatment for cachexia in patients with gynecological cancers: evaluating the impact on metabolic and inflammatory profiles and quality of lifeAntonio Maccio
Department of Obstetrics and Gynecology, Sirai Hospital, Carbonia, Italy
Gynecol Oncol 124:417-25. 2012..alterations and by symptoms including fatigue, anorexia, nausea, anemia, and immunodepression, which result in a cachexia syndrome and a marked decrease in patient quality of life (QoL)...
- The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouseJames P White
Department of Exercise Science, University of South Carolina, Columbia, South Carolina, United States of America
PLoS ONE 6:e24650. 2011Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation...
- Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mousePaola Aulino
Department of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 16, 00161 Rome, Italy
BMC Cancer 10:363. 2010The majority of cancer patients experience dramatic weight loss, due to cachexia and consisting of skeletal muscle and fat tissue wasting...
- Rheumatoid cachexia and cardiovascular diseaseGregory D Summers
Department of Rheumatology, Royal Derby Hospital, Derby DE22 3NE, UK
Nat Rev Rheumatol 6:445-51. 2010Both cachexia and cardiovascular disease are strongly associated with rheumatoid arthritis (RA) and linked to the chronic inflammatory process...
- Muscle oxidative capacity during IL-6-dependent cancer cachexiaJames P White
Dept of Exercise Science, University of South Carolina, Public Health Research Center, Rm 405, 921 Assembly St, Columbia, SC 29208, USA
Am J Physiol Regul Integr Comp Physiol 300:R201-11. 2011..between muscle oxidative capacity and muscle mass loss in red and white hindlimb muscles during cancer cachexia development in the Apc(Min/+) mouse...
- Molecular pathways leading to cancer cachexiaMichael J Tisdale
Cancer Biochemistry, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom
Physiology (Bethesda) 20:340-8. 2005..Recent studies have suggested that both tumor and host factors play a major role in tissue catabolism in cachexia, leading to upregulation of degradative pathways in both skeletal muscle and adipose tissue.
- Signaling pathways perturbing muscle massDavid J Glass
Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
Curr Opin Clin Nutr Metab Care 13:225-9. 2010To discuss the mechanisms of muscle loss during cachexia.
- Treatment of cachexia with ghrelin in patients with COPDNoritoshi Nagaya
Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
Chest 128:1187-93. 2005..We investigated whether ghrelin improves cachexia and functional capacity in patients with COPD.
- Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing miceKate T Murphy
Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Victoria, Australia
Am J Physiol Regul Integr Comp Physiol 301:R716-26. 2011Cancer cachexia describes the progressive skeletal muscle wasting and weakness in many cancer patients and accounts for >20% of cancer-related deaths...
- The experience of cancer cachexia: a qualitative study of advanced cancer patients and their family membersJoanne Reid
Unit of Nursing and Midwifery Research, Queen s University Belfast Belfast Health and Social Care Trust, Lisburn Road, Belfast, UK
Int J Nurs Stud 46:606-16. 2009b>Cachexia in advanced malignancy is a debilitating syndrome which contributes to approximately two million deaths worldwide annually...
- Pre-cachexia in patients with stages I-III non-small cell lung cancer: systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome systemC M Op den Kamp
Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Lung Cancer 76:112-7. 2012b>Cachexia is a prevalent phenomenon of non-small cell lung cancer (NSCLC) which is responsible for increased mortality and deterioration of physical performance...
- Understanding the mechanisms and treatment options in cancer cachexiaKenneth Fearon
Clinical Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, Edinburgh, UK
Nat Rev Clin Oncol 10:90-9. 2013Cancer cachexia is a metabolic syndrome that can be present even in the absence of weight loss ('precachexia'). Cachexia is often compounded by pre-existing muscle loss, and is exacerbated by cancer therapy...
- Myostatin is a novel tumoral factor that induces cancer cachexiaSudarsanareddy Lokireddy
School of Biological Sciences, Nanyang Technological University, Singapore
Biochem J 446:23-36. 2012..is a lack of information regarding the tumoral factors that contribute to the atrophy of muscle during cancer cachexia. Therefore, in the present study, we have characterized the secretome of C26 colon cancer cells to identify the ..
- NF-κB inhibition protects against tumor-induced cardiac atrophy in vivoAshley Wysong
Duke University School of Medicine, Durham, North Carolina, USA
Am J Pathol 178:1059-68. 2011Cancer cachexia is a severe wasting syndrome characterized by the progressive loss of lean body mass and systemic inflammation...
- Cachexia assessment toolsDavid Blum
European Palliative Reasearch Center, Department of Cancer Research and Molecular Medicine, NTNU, Faculty of Medicine, Trondheim, Norway
Curr Opin Support Palliat Care 5:350-5. 2011b>Cachexia is a common negative consequence of cancer and is often unrecognized. To assess cachexia, malnutrition assessment tools are used...
- Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactionsPeter G Arthur
School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Australia
Curr Opin Clin Nutr Metab Care 11:408-16. 2008..Understanding these interactions in vivo will assist in identifying opportunities for more targeted therapies to reduce skeletal muscle wasting...
- Both oxidative and nitrosative stress are associated with muscle wasting in tumour-bearing ratsEsther Barreiro
Muscle and Respiratory System Research Unit, IMIM and CEXS, Universitat Pompeu Fabra, Barcelona, Spain
FEBS Lett 579:1646-52. 2005Reactive oxygen and nitrogen species (ROS and RNS) have been proposed as mechanisms of cancer-induced cachexia. In this study, we assessed using Western blot analysis the levels of total protein carbonylation (2,4-dinitrophenylhydrazine ..
- Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategiesShontelle Dodson
GTx, Inc, Memphis, Tennessee 38103 2802, USA
Annu Rev Med 62:265-79. 2011Cancer cachexia is a complex metabolic condition characterized by loss of skeletal muscle...
- Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexiaJ E Belizario
Department of Pharmacology of Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, 05508 900, Brazil
Br J Cancer 84:1135-40. 2001A prominent feature of several type of cancer is cachexia. This syndrome causes a marked loss of lean body mass and muscle wasting, and appears to be mediated by cytokines and tumour products...
- Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing miceMichelle L Asp
Department of Human Nutrition, College of Education and Human Ecology, The Ohio State University, Columbus, Ohio, USA
Int J Cancer 126:756-63. 2010Cancer cachexia is a syndrome of unintentional weight loss that is characterized by wasting of both skeletal muscle and adipose tissue. Glucose intolerance and insulin resistance have been associated with cancer cachexia...
- Steep elevation of blood interleukin-6 (IL-6) associated only with late stages of cachexia in cancer patientsSatoru Iwase
Department of Palliative Medicine, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Eur Cytokine Netw 15:312-6. 2004..cytokines of 28, consenting, terminally ill cancer patients were studied to determine a relationship between cachexia and changes in cytokine levels...
- Daily physical-rest activities in relation to nutritional state, metabolism, and quality of life in cancer patients with progressive cachexiaMarita Fouladiun
Surgical Metabolic Research Laboratory at Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg, Sweden
Clin Cancer Res 13:6379-85. 2007..To evaluate daily physical-rest activities in cancer patients losing weight in relation to disease progression...
- Cachexia: prevalence and impact in medicineBenjamin H L Tan
Clinical and Surgical Sciences Surgery, University of Edinburgh, Royal Infirmary, Edinburgh, UK
Curr Opin Clin Nutr Metab Care 11:400-7. 2008b>Cachexia is a progressive deterioration of body habitus associated with certain chronic diseases (e.g., cancer, chronic obstructive pulmonary disease, chronic heart failure, and chronic kidney disease)...
- Inflammation and cachexia in chronic kidney diseaseWai W Cheung
Division of Pediatrics Nephrology, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093 0634, USA
Pediatr Nephrol 25:711-24. 2010Chronic inflammation is associated with cachexia and increased mortality risk in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Inflammation suppresses appetite and causes the loss of protein stores...
- Interleukin 6 as a key regulator of muscle mass during cachexiaJames A Carson
Division of Applied Physiology, Department of Exercise Science, Integrative Muscle Biology Lab, University of South Carolina, Columbia, SC 29208, USA
Exerc Sport Sci Rev 38:168-76. 2010Interleukin 6 (IL-6) has received significant attention for its regulatory role in muscle wasting during cachexia. This review examines the role of circulating IL-6 for decreasing muscle mass during cancer and emphasizes some of the ..
- Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in miceWai W Cheung
Department of Pediatric, University of California at San Diego, 9500 Gilman Drive, MC 0634, La Jolla, CA 92093 0634, USA
J Am Soc Nephrol 18:2517-24. 2007..that genetic or pharmacological blockade of the melanocortin-4 receptor (MC4-R) attenuates uremia-associated cachexia. However, the potential clinical utility of this approach has been limited by the need to deliver a peptide MC4-R ..
- Can progressive resistance training reverse cachexia in patients with rheumatoid arthritis? Results of a pilot studySamuele M Marcora
School of Sport, Health and Exercise Sciences, University of Wales Bangor, and Department of Rheumatology, Gwynedd Hospital, Bangor, Wales, UK
J Rheumatol 32:1031-9. 2005A Phase II trial was performed as a preliminary test of the efficacy and safety of progressive resistance training (PRT) as adjunct treatment for rheumatoid cachexia.
- Cachexia worsens prognosis in patients with resectable pancreatic cancerJeannine Bachmann
Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
J Gastrointest Surg 12:1193-201. 2008..Remarkably, there are only a few data available on the impact of cachexia in patients with pancreatic cancer scheduled for tumor resection.
- Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stressMaria Cristina C Gomes-Marcondes
Department of Physiology and Biophysics, University of Campinas, UNICAMP, SP Brazil
Cancer Lett 180:69-74. 2002Muscle wasting in cancer cachexia is associated with increased levels of malondialdehyde (MDA) in gastrocnemius muscles, suggesting an increased oxidative stress...
- Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosisKenneth C Fearon
Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
Am J Clin Nutr 83:1345-50. 2006Cancer cachexia is a multifactorial syndrome that is poorly defined.
- Role of leptin and melanocortin signaling in uremia-associated cachexiaWai Cheung
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
J Clin Invest 115:1659-65. 2005The pathogenesis of cachexia in patients with uremia is unknown. We tested the hypothesis that uremia-associated cachexia is caused by leptin signaling through the hypothalamic melanocortin receptor 4 (MC4-R)...
- Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexiaMargaret E Benny Klimek
Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Biochem Biophys Res Commun 391:1548-54. 2010b>Cachexia, progressive loss of fat and muscle mass despite adequate nutrition, is a devastating complication of cancer associated with poor quality of life and increased mortality. Myostatin is a potent tonic muscle growth inhibitor...
- The role of cytokines in cancer cachexiaJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
Curr Opin Support Palliat Care 3:263-8. 2009..The present investigation is devoted to uncovering the different signaling pathways - particularly transcriptional factors - involved in muscle wasting...
- Cancer cachexia: developing multimodal therapy for a multidimensional problemK C H Fearon
Clinical and Surgical Sciences Surgery, School of Clinical Sciences and Community Health, University of Edinburgh, Royal Infirmary, 51 Little France Crescent, Edinburgh, United Kingdom
Eur J Cancer 44:1124-32. 2008Cancer cachexia is a multi-factorial syndrome that encompasses a spectrum from early weight loss (pre-cachexia) to a state of severe incapacity incompatible with life...
- Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary diseaseTakefumi Itoh
Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
Am J Respir Crit Care Med 170:879-82. 2004..In conclusion, plasma ghrelin was elevated in underweight patients with chronic obstructive pulmonary disease, and the level was associated with a cachectic state and abnormality of pulmonary function...
- Cardiac cachexia: a systematic overviewStephan von Haehling
Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
Pharmacol Ther 121:227-52. 2009Cardiac cachexia as a terminal stage of chronic heart failure carries a poor prognosis. The definition of this clinical syndrome has been a matter of debate in recent years...
- Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexiaChen Bing
Neuroendocrine and Obesity Biology Unit, Department of Medicine, University Clinical Departments, University of Liverpool, Liverpool L69 3GA, UK
Proc Natl Acad Sci U S A 101:2500-5. 2004..human malignant tumors and acts as a lipid-mobilizing factor to stimulate lipolysis in adipocytes leading to cachexia in mice implanted with ZAG-producing tumors...
- The causes and consequences of cancer-associated malnutritionEric Van Cutsem
Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium
Eur J Oncol Nurs 9:S51-63. 2005..such as pro-inflammatory cytokines and hormones, have been implicated in the pathogenesis of malnutrition and cachexia. The consequences of malnutrition include impairment of immune functions, performance status, muscle function, ..
- Zinc alpha-2-glycoprotein is expressed by malignant prostatic epithelium and may serve as a potential serum marker for prostate cancerL P Hale
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Cancer Res 7:846-53. 2001..ZAG was recently shown to stimulate lipolysis in adipocytes, leading to the development of cachexia in animals with ZAG-producing tumors...
- Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stressGiovanni Mantovani
Department of Medical Oncology, Policlinico Universitario, University of Cagliari, Strada Statale 554 bivio Sestu, 09042 Monserrato, Italy
J Mol Med (Berl) 81:664-73. 2003This study assessed in a wide population of advanced cancer patients the biological parameters relevant to cancer cachexia, such as serum levels of proinflammatory cytokines (IL-1beta, IL-6, TNFalpha), IL-2, acute-phase proteins (C-..
- Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failureN Nagaya
Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Suita, Osaka, Japan
Circulation 104:1430-5. 2001..We investigated whether ghrelin improves left ventricular (LV) dysfunction and attenuates cardiac cachexia in rats with chronic heart failure (CHF).
- Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexiaSwarnali Acharyya
Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA
Cancer Cell 8:421-32. 2005b>Cachexia contributes to nearly a third of all cancer deaths, yet the mechanisms underlying skeletal muscle wasting in this syndrome remain poorly defined...
- Pathophysiological role of hormones and cytokines in cancer cachexiaHyun Jung Kim
Division of Hematology and Oncology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea
J Korean Med Sci 27:128-34. 2012..In total, 21 patients were included in the cachexia group and the others served as a comparison group...
- Anaerobic exercise reduces tumor growth, cancer cachexia and increases macrophage and lymphocyte response in Walker 256 tumor-bearing ratsCarina de Lima
Department of Physiology, Biological Science Building, Federal University of Parana, Curitiba, PR, Brazil
Eur J Appl Physiol 104:957-64. 2008Here, we investigated the effect of jump exercise on tumor growth, cancer cachexia, lymphocyte proliferation and macrophage function in Walker 256 tumor-bearing rats...
- Regulation of lipolysis: natriuretic peptides and the development of cachexiaPaul R Kalra
Clinical Cardiology, National Heart and Lung Institute, London, UK
Int J Cardiol 85:125-32. 2002The development of cachexia is commonly seen in many pathological states and is associated with a markedly impaired prognosis. Loss of fat tissue appears to be of particular pathophysiological importance in this setting...
- Adipose tissue inflammation and cancer cachexia: possible role of nuclear transcription factorsM L Batista
Laboratory of Adipose Tissue Biology, Center for Integrated Biotechnology, University of Mogi das Cruzes, Mogi das Cruzes, Sao Paulo, Brazil
Cytokine 57:9-16. 2012Cancer cachexia is a multifaceted syndrome whose aetiology is extremely complex and is directly related to poor patient prognosis and survival...
- Are inflammatory cytokines the common link between cancer-associated cachexia and depression?James Illman
Centocor, Inc, Malvern, Pennsylvania, USA
J Support Oncol 3:37-50. 2005..Cancer-related depression often occurs in association with anorexia and cachexia, although until recently the relationship between these conditions has not been well understood...
- Lipid mobilization in cachexia: mechanisms and mediatorsChen Bing
Department of Obesity and Endocrinology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
Curr Opin Support Palliat Care 5:356-60. 2011Extensive loss of body fat is considered as a hallmark of cancer cachexia which affects the quality of life and shortens survival. Evidence suggests that increased lipid mobilization has a central role in adipose tissue wasting...
- Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexiaMelissa J Puppa
Department of Exercise Science, University of South Carolina, Columbia, SC 29208, USA
Biochim Biophys Acta 1812:1601-6. 2011The Apc(Min/+) mouse, an animal model of colorectal cancer and cachexia, has a heterologous mutation in the Apc tumor suppressor gene, predisposing the mouse to intestinal and colon tumor development...
- Cancer anorexia-cachexia syndrome: psychological effect on the patient and familySusan McClement
Faculty of Nursing, University of Manitoba, Research Associate, Winnipeg, Manitoba, Canada
J Wound Ostomy Continence Nurs 32:264-8. 2005..Chronic nausea and early satiety may also occur. This constellation of symptoms is known as the cancer anorexia-cachexia syndrome...
- Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexiaR A Murphy
Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, 4 126 Li Ka Shing Center, Edmonton, AB T6G 2E1, Canada
Br J Cancer 105:1469-73. 2011Cancer cachexia is characterised by a progressive loss of muscle, resulting in functional impairment and shorter survival...
- Adipocytokines and squamous cell carcinoma of the esophagusTakako Eguchi Nakajima
Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
J Cancer Res Clin Oncol 136:261-6. 2010..that the impaired response of adipocytokines to body weight loss may play a role in the pathogenesis of cancer-induced cachexia. We investigated the association between adipocytokines with squamous cell carcinoma of the esophagus (SCCE).
- Cachexia, malnutrition, the refeeding syndrome, and lessons from GoldilocksJ Alexander Palesty
Department of Surgery, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
Surg Clin North Am 91:653-73. 2011b>Cachexia has plagued clinicians for centuries. Although all cachexia is related to malnutrition, cachexia associated with malignant diseases differs from starvation cachexia in that it is more recalcitrant to nutritional therapy...
- What is cancer anorexia-cachexia syndrome? A historical perspectiveN Bennani-Baiti
Section of Palliative Medicine and Supportive Oncology, The Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
J R Coll Physicians Edinb 39:257-62. 2009Cancer anorexia-cachexia syndrome (CACS) is a lethal but poorly defined involuntary wasting disorder. Loss of skeletal muscle and fat distinguishes it from starvation...
- Central tenet of cancer cachexia therapy: do patients with advanced cancer have exploitable anabolic potential?Carla M Prado
Department of Nutrition, Food and Exercise Sciences, The Florida State University, Tallahassee, FL
Am J Clin Nutr 98:1012-9. 2013Skeletal muscle wasting is considered the central feature of cachexia, but the potential for skeletal muscle anabolism in patients with advanced cancer is unproven.
- Characterization of a cancer cachectic factorP Todorov
CRC Nutritional Biochemistry Research Group, Pharmaceutical Sciences Institute, Aston University, Birmingham UK
Nature 379:739-42. 1996Cancer cachexia is a syndrome of progressive wasting which has been suggested to be mediated by tumour-necrosis factor-alpha, interleukins 1 and 6, interferon-gamma and leukaemia-inhibitory factor...
- Loss of skeletal muscle mass in aging: examining the relationship of starvation, sarcopenia and cachexiaDavid R Thomas
Division of Geriatric Medicine, Saint Louis University Medical Center, Saint Louis, MO 63104, USA
Clin Nutr 26:389-99. 2007..Involuntary weight loss can be categorized into three primary etiologies of starvation, sarcopenia, and cachexia. Starvation results in a loss of body fat and non-fat mass due to inadequate intake of protein and energy...
- Cancer cachexia and targeting chronic inflammation: a unified approach to cancer treatment and palliative/supportive careNeil MacDonald
McGill Cancer Nutrition and Rehabilitation Programme, McGill University, Montreal, Quebec, Canada
J Support Oncol 5:157-62; discussion 164-6, 183. 2007..Many of the same inflammatory factors that promote tumor growth also are responsible for cancer cachexia/anorexia, pain, debilitation, and shortened survival...
- Possible mechanisms underlying the development of cachexia in COPDP D Wagner
Division of Physiology, Dept of Medicine, University of California, San Diego, 9500 Gilman Drive, DEPT 0623A, La Jolla, CA 92093 0623A, USA
Eur Respir J 31:492-501. 2008About 25% of patients with chronic obstructive pulmonary disease (COPD) will develop cachexia (fat-free body mass index <17 kg.m(-2) (males) or <14 kg.m(-2) (females))...
- Expression of NF-kappaB and IkappaB proteins in skeletal muscle of gastric cancer patientsMary G Rhoads
Department of Health Sciences, Boston University, Boston, MA, USA
Eur J Cancer 46:191-7. 2010The mechanisms eliciting cancer cachexia are not well understood. Wasting of skeletal muscle is problematic because it is responsible for the clinical deterioration in cancer patients and for the ability to tolerate cancer treatment...
- Interleukin 6/interleukin 6 receptor interaction and its role as a therapeutic target for treatment of cachexia and cancerUlrich H Weidle
Roche Diagnostics, Division Pharma, Im Nonnenwald 2, Penzberg, Germany
Cancer Genomics Proteomics 7:287-302. 2010..of IL6 signaling with monoclonal antibodies directed against IL6 or IL6R and their potential impact for treatment of tumor-associated cachexia and as antitumoral agents as monotherapy and in combination with small molecule compounds.
- Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexiaW Doehner
Department of Clinical Cardiology, NHLI, Imperial College School of Medicine, London, UK
Eur J Endocrinol 145:727-35. 2001..This study aimed to examine the influence of leptin on GHBP in CHF patients with and without cardiac cachexia compared with healthy control subjects.
- Cytokines and their relationship to the symptoms and outcome of cancerBostjan Seruga
Division of Medical Oncology, Princess Margaret Hospital, St Michael s Hospital, University of Toronto, Toronto, Canada
Nat Rev Cancer 8:887-99. 2008..In people with advanced cancer, pro-inflammatory cytokines are additionally associated with anorexia and cachexia, pain, toxicity of treatment and resistance to treatment...
- Role of the central melanocortin system in cachexiaD L Marks
Department of Pediatric Endocrinology, Oregon Health Sciences University, Portland 97201, USA
Cancer Res 61:1432-8. 2001..In some cases, a devastating state of malnutrition known as cachexia arises, brought about by a synergistic combination of a dramatic decrease in appetite and an increase in ..
- Update on clinical trials of growth factors and anabolic steroids in cachexia and wastingNorleena P Gullett
Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA
Am J Clin Nutr 91:1143S-1147S. 2010..chronic diseases, which include chronic kidney disease, cancer, and AIDS, were presented at a symposium entitled "Cachexia and Wasting: Recent Breakthroughs in Understanding and Opportunities for Intervention," held at Experimental ..
- The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertensionC W le Roux
Heart 91:241-2. 2005
- Anti-inflammatory therapies in cancer cachexiaJosep M Argiles
Cancer Research Group, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Eur J Pharmacol 668:S81-6. 2011..and neurons, where they produce a complex cascade of biological responses leading to the wasting associated with cachexia. The cytokines that have been involved in this cachectic response are TNF-alpha, IL-1, IL-6 and interferon-gamma...
- Cancer cachexia: a systematic literature review of items and domains associated with involuntary weight loss in cancerDavid Blum
Oncological Palliative Medicine, Division of Oncology Hematology, Department of Internal Medicine and Palliative Care Center, Cantonal Hospital, St Gallen, Switzerland
Crit Rev Oncol Hematol 80:114-44. 2011The concept of cancer-related anorexia/cachexia is evolving as its mechanisms are better understood...
- Body composition and plasma levels of inflammatory biomarkers in COPDT M L Eagan
Dept of Thoracic Medicine, Haukeland University Hospital, Jonas Lies vei, 5021 Bergen, Norway
Eur Respir J 36:1027-33. 2010..14 (-0.23- -0.04), whereas FFMI was unrelated to OPG. In conclusion, COPD patients with low FFMI had lower not higher plasma levels of CRP and sTNF-R1, whereas higher fat mass was associated with higher CRP and sTNF-R1 and lower OPG...
- Effect of eicosapentaenoic acid (EPA) on expression of a lipid mobilizing factor in adipose tissue in cancer cachexiaS T Russell
Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
Prostaglandins Leukot Essent Fatty Acids 72:409-14. 2005Adipose tissue of mice bearing a cachexia-inducing murine tumour (MAC16) shows increased expression of zinc-alpha(2)-glycoprotein (ZAG), a lipolytic factor thought to be responsible for the increased lipolysis...
- Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidantsM Buck
Department of Medicine, Veterans Affairs Medical Center, San Diego, CA, USA
EMBO J 15:1753-65. 1996..The decreased body weight, muscle wasting and skeletal muscle molecular abnormalities of cachexia were prevented by treatment of TNF alpha mice with the antioxidants D-alpha-tocopherol of BW755c, or the NOS ..
- The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intakeNILS WG LAMBRECHT; Fiscal Year: 2012..MBOAT4, ghrelin-O-acyl transferase (GOAT), food intake, peripheral regulation, gastric mucosal X/A cell, obesity, cachexia, LPS BRIEF STATEMENT OF RESEARCH OBJECTIVES (Do not use continuation sheets) Chronic changes in body weight ..
- Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related caJose M Garcia; Fiscal Year: 2013..Project Summary/Abstract Every year, over 1.5 million individuals in the US are diagnosed with cancer. Cachexia, defined as an involuntary weight loss >5%, is present in up to 80% of these patients and it encompasses the ..
- Role of leptin-mediated PI3 Kinase signaling on reproductive controlCarol Fuzeti Elias; Fiscal Year: 2013..In humans, states of negative energy balance as in anorexia, cachexia, and excessive exercise can all decrease gonadotropins secretion resulting in abnormal cyclicity and infertility...
- Nutrition and Anabolic Interventions in Cancer CachexiaMelinda Sheffield-Moore; Fiscal Year: 2013Project Summary/Abstract Cancer cachexia severely depletes skeletal muscle mass leading to impairments in physical function and a diminished quality of life. In the clinical realm, malnutrition and cachexia are synonymous...
- Muscle stem cell therapy in a mouse model of premature agingJohnny Huard; Fiscal Year: 2010..Both mice develop age-related pathologies including ataxia, kyphosis, cachexia, disc degeneration, osteoporosis, incontinence, epidermal atrophy, sarcopenia, bone marrow degeneration and liver ..
- Experimental COPD: remediation, mitigationDONALD JOHN MASSARO; Fiscal Year: 2010..b>Cachexia in people with COPD signals a rapid downhill course...
- Body composition, bone structure, and joint damage in rheumatoid arthritisJoshua F Baker; Fiscal Year: 2013..Given that 1) rheumatoid cachexia is characterized by reduced lean mass with normal or increased fat mass and 2) low lean mass is associated with ..
- Brain interleukin-18 control of food intake and energy expenditureEric P Zorrilla; Fiscal Year: 2013..Translationally, this function would make IL-18 a clinically relevant target for sickness syndrome/cachexia. Moreover, because IL-18 administration does not share "sickness syndrome" effects of the pro-inflammatory system,..
- CONTROL OF GONADOTROPIN SECRETION DURING LACTATIONKevin L Grove; Fiscal Year: 2013..by applicant): It is firmly established that states of energy deficiency, such as fasting, anorexia nervosa, cachexia, bulimia, lactation and exercise-induced amenorrhea, as well as states of energy overabundance, such as obesity, ..
- Identification of key tumor cell-released factors that induce cachexiaYi Ping Li; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cachexia, a wasting disease characterized by progressive loss of muscle with or without loss of fat mass, is frequently associated with cancer and is estimated to be the immediate cause of death in 20%..
- Eicosapentaenoic acid and protein modulation to induce anabolism in COPDMARIELLE PKJ ENGELEN; Fiscal Year: 2012..altered regulation of protein metabolism, which result initially in muscle atrophy only but in later stages in cachexia. Despite the well-recognized importance of treating cachexia in COPD with appropriate nutrition, current ..
- Inflammatory Cytokine regulation of POMC and Orexin neurons in cachexia.AARON GROSSBERG; Fiscal Year: 2012..This constellation of findings closely resembles cachexia, a state of disease-associated wasting common to many chronic diseases...
- The Molecular Basis of Muscle Wasting in Cancer CachexiaSUSAN KANDARIAN; Fiscal Year: 2013..DESCRIPTION (provided by applicant): Approximately two million people die world-wide of the consequences of cancer cachexia annually...
- Angiotensin II, IGF-1 and Skeletal Muscle AtrophyPatrice Delafontaine; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cachexia is a major complication of chronic diseases such as heart failure, kidney failure and cancer. In these conditions the renin-angiotensin system (RAS) is often activated...
- The effects of glucose on central vagal brainstem circuitsKIRSTEEN NAIRN BROWNING; Fiscal Year: 2013..a variety of pathological conditions, including, for example, functional gastric motility disorders, obesity or cachexia. The specific mechanisms by which glucose can reorganize vagally-mediated gastrointestinal visceral reflexes are ..
- The Role of the Central Melanocortin System in the Muscle Wasting of CachexiaTHEODORE PAUL BRAUN; Fiscal Year: 2013..research is to understand the role of the central melanocortin system In the pathogenesis of muscle wasting in cachexia. A patient's ability to maintain lean mass is an important factor in quality of life as well as an important ..
- Hypothalamic Mechanisms in CachexiaDaniel L Marks; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cachexia, or disease-associated wasting, is a common occurrence in cancer, renal failure, and infectious disease...
- Targeting Adipocyte Lipases to Treat Pancreatic Cancer-Associated CachexiaEnrique Saez; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cachexia is a progressive atrophy of adipose tissue and skeletal muscle that occurs in more than 85% of pancreatic ductal adenocarcinoma (PDAC) patients...
- NO-dependent SOD3 protection against cachexiaZhen Yan; Fiscal Year: 2012DESCRIPTION (provided by applicant): Cachexia is a serious medical condition in many chronic diseases, such as cancer, chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), chronic kidney disease (CKD) and some ..
- Long lasting ghrelin derivatives for the treatment of cancer cachexiaTARIK SOLIMAN; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cachexia is a complex syndrome characterized by involuntary weight loss and skeletal muscle wasting that leads to fatigue, weakness and a loss of appetite that is not reversed by increased caloric ..
- Role of Ca2+/calmodulin kinases in skeletal muscle glucose transport and growth.CAROL WITCZAK; Fiscal Year: 2013Skeletal muscle metabolic dysfunction and atrophy are prominent features of cachexia, a complex and devastating syndrome characterized by loss of body weight, loss of skeletal muscle and fat mass, and skeletal muscle weakness...
- Role of Parabrachial Nucleus Neuropeptides in FeedingJohn Paul Baird; Fiscal Year: 2011..RELEVANCE: Feeding and metabolic disorders such as obesity, anorexia, bulimia, failure to thrive, gastric reflux, cachexia, early satiety, delayed gastric emptying, dysgeusia, and anosmia contribute to diseases including hypertension, ..
- Metabolic Actions of Brain Leptin Receptors Signaling in Type 1 DiabetesRoberto Coppari; Fiscal Year: 2012..These therapies reduce hyperglycemia, glycosylated hemoglobin, cachexia and prevent or delay some of T1D-associated morbidities...
- Characterization of myostatin and GDF-11Se Jin Lee; Fiscal Year: 2013..and strength in patients with muscle degenerative and wasting diseases, like muscular dystrophy, sarcopenia, and cachexia, which is often seen in patients with diseases like cancer, AIDS, and sepsis...
- p38 MAPK a regulator of muscle contraction and functionZhen Yan; Fiscal Year: 2013..of this extremely important signaling pathway will facilitate the development of new interventions for numerous medical conditions, such as cardiac cachexia and type 2 diabetes that are profoundly influenced by skeletal muscle function.
- ACTIVATORS OF MUSCLE GENESHelen M Blau; Fiscal Year: 2013..treating skeletal muscle diseases, including genetic defects and muscle wasting conditions such as sarcopenia and cachexia. The therapeutic utility of MuSCs is limited by the rarity of these cells in adult tissues and the inability to ..
- Molecular Pathogenesis and Treatment of MNGIEMichio Hirano; Fiscal Year: 2013..in childhood or early adulthood causes ptosis, ophthalmoplegia, severe gastrointestinal dysmotility leading to cachexia, peripheral neuropathy, leukoencephalopathy, and alterations of mitochondrial DNA (mtDNA)...
- Molecular Mechanisms that Cause Muscle AtrophyAlfred L Goldberg; Fiscal Year: 2012..g. cancer cachexia, renal failure) and aging...
- RGK proteins and aging muscleROGER ALAN BANNISTER; Fiscal Year: 2012..in the course of this study may also contribute to a better understanding of muscle weakness associated with cachexia, diabetes and degenerative neuromuscular disease...
- Circadian rhythms and skeletal muscleKARYN ANN ESSER; Fiscal Year: 2012..for maintenance of muscle with an impact on our understanding and treatment of sarcopenia, muscle wasting/cachexia and problems associated with metabolic diseases such as insulin resistance...
- Profiling and Characterizing Prostate Cancer Tumor Dormancy in the Bone MarrowROBERT LOUIS VESSELLA; Fiscal Year: 2010..and their activation can lead to the replacement of bone marrow (BM), spinal cord compression, severe bone pain, cachexia and death...
- TRAINING GRANT IN ACADEMIC ENDOCRINOLOGYPHILIP REED LARSEN; Fiscal Year: 2013..particularly in the hypothalamus, the control of skeletal muscle repair and mechanisms of muscle proteolysis in cachexia and muscle atrophy, the mechanisms of steroid hormone action and the epidemiology of diabetes, obesity, and ..
- Role of neuropeptide Y-glucose inhibited (NPY-GI) neurons in cytokine-induced anoVanessa H Routh; Fiscal Year: 2010Anorexia-cachexia occurs because detection of energy deficit by the brain becomes impaired due to cytokine excess...
- Acute Lung Injury Induces Skeletal Muscle AtrophyDaniel Clark Files; Fiscal Year: 2010..will also investigate whether the apparent suppression of appetite in these animals is indicative of a state of cachexia and how this state may alter muscle wasting and impair the recovery process...
- Calcineurin signaling, PGC-1 alpha and protein-energy wasting in kidney diseaseS Russ Price; Fiscal Year: 2013..peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) is decreased during CKD and other cachexia-inducing conditions...
- Mechanisms underlying myostatin regulation and activitySe Jin Lee; Fiscal Year: 2013..states characterized by debilitating muscle loss, including muscle degenerative diseases, neuromuscular diseases, cachexia, and age-related sarcopenia...
- A photographic method for human body composition assessmentHELEN OLIVIA AFFUSO; Fiscal Year: 2013..including obesity and sarcopenia, whose very definitions depend on assessment of fat and fat free mass, but also cachexia induced by HIV, cancer, and other diseases;multiple sclerosis;wasting in neurological disorders such as Parkinson&..
- PET/CT of skeletal muscle amino acid kineticsThomas F Lang; Fiscal Year: 2013..of conditions such as Type 2 Diabetes, protease inhibitor therapy for HIV, chronic kidney disease and cancer cachexia. Clinical research studies investigating the pathophysiology and treatment of muscle loss often utilize CT and ..
- Characterization of the Insulin to Autophagy Pathway in MusclesNorbert Perrimon; Fiscal Year: 2013..signaling and the basic cellular machinery involved in protein degradation, we expect that our studies will be directly relevant to the understanding of muscle wasting associated with muscular dystrophies, cachexia and sarcopenia.
- Pre-Clinical and Clinical Evaluation of Skeletal Muscle Activator, CK-2017357 forMALAR PANNIRSELVAM; Fiscal Year: 2012..intermittent claudication (cramping pains in the legs caused by peripheral arterial disease), muscle wasting (cachexia) associated with cancer, heart failure or other diseases, and the frailty associated with aging (also known as ..
- Leica Laser Microdissection Microscope for a Shared ResourceMartha L Campbell-Thompson; Fiscal Year: 2013..inflammatory response syndromes and to chronic inflammatory processes, including cancer and AIDS-associated cachexia. He too has active NIH funding for studies with laser capture microdissection for arterial venous fistula...
- Melanocortin Ligands in Disease CachexiaKENNETH ALLEN GRUBER; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cachexia-anorexia syndrome is a life-threatening aspect to many diseases, in particular many forms of cancer or therapies for cancer...
- Long-acting Growth Hormone for Treating HIV-Associated Adipose Redistribution SynGeorge Cox; Fiscal Year: 2009..GH analog for the treatment of HARS and other metabolic complications of HIV and HIV therapies such as wasting (cachexia)...
- Dissection of a Developmental Checkpoint That Preserves Regenerative CapacityADRIAN J HALME; Fiscal Year: 2013..damage and inflammation can produce systemic effects on growth and endocrine control of development, which are each observed in clinical examples of persistent inflammation such as obesity-related insulin resistance and cancer cachexia.
- Isoform-specific roles of the Na,K-ATPase in skeletal muscleJerry B Lingrel; Fiscal Year: 2013..Skeletal muscle weakness and fatigue is a common, debilitating condition in heart failure, sarcopenia, cachexia, muscular dystrophies, COPD, and other disorders...
- Chemical probes that target Stat3 to treat cancerDAVID JOHN TWEARDY; Fiscal Year: 2013..murine bone marrow colony formation in vitro, and, prevented weight loss and sarcopenia in a murine model of cachexia. The specific hypothesis that will be examined in this Phase I STTR is that C188-9 or one of its derivatives will ..
- Manipulation of STAT3 Signaling for Muscle Preservation in Cancer CachexiaTeresa A Zimmers; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cachexia, or progressive wasting of fat and skeletal muscle despite adequate nutrition, is a devastating complication of cancer...
- Ubiquitin-like Protein Transfer CascadesBrenda A Schulman; Fiscal Year: 2013..with diseases, including cancers, developmental disorders, high blood pressure, neurodegenerative disorders, and cachexia. We propose to extend our expertise on UBL conjugation to the two largest E3 families: RING (Really Interesting ..
- Carbohydrate Appetite, Fat Appetite and ObesityAnthony Sclafani; Fiscal Year: 2013..This knowledge may also be applied to promote eating in clinical cases of anorexia and cachexia.
- PQ6 MECHANISMS OF CACHEXIA LIKE WASTING IN A DROSPHILA CANCER MODELDavid Bilder; Fiscal Year: 2013DESCRIPTION (provided by applicant): Cancer cachexia, a wasting syndrome characterized by the dramatic loss of skeletal muscle and adipose tissue, is perhaps the most poorly understood feature of cancer pathophysiology...
- Myostatin Family Signaling in Burn-Injury Related Muscle WastingTeresa A Zimmers; Fiscal Year: 2013..However, persistent cachexia in the convalescent phase is pathological in itself...
- Genetic modification of aging and diseased striated muscleJeffrey S Chamberlain; Fiscal Year: 2013..wasting disorders, such as muscle loss during aging (sarcopenia) and muscle atrophy associated with cancer (cachexia). Our primary focus will be on aging normal and mdx mice, a model for DMD/BMD...
- A comparative approach to evaluate muscle growth in an indeterminate growth modelPeggy R Biga; Fiscal Year: 2011DESCRIPTION (provided by applicant): Project Summary Muscle wasting syndrome and cachexia are associated with many degenerative diseases, like cancer, AIDS, and other systemic diseases...
- Ghrelin and Strength Training in Frail ElderlyAnne R Cappola; Fiscal Year: 2012..It has been studied in over 300 humans, including those with specific diseases that cause cachexia (e.g. renal failure, cancer), but not in frail individuals...
- A20 (TNFAIP3) Regulation of Intestinal Immune HomeostasisTIMOTHY THEN CHIOH LU; Fiscal Year: 2012..develop spontaneous intestinal inflammation and die perinatally due to spontaneous systemic inflammation and cachexia. Recent genetic studies have identified TNFAIP3 as a candidate gene associated with inflammatory bowel disease...
- The PRESS ERA: Protein &Resistance Exercise Supplement Study for Elderly with RARebecca Manno; Fiscal Year: 2013..combination of exercise and nutritional interventions have been suggested as important treatments for rheumatoid cachexia and older frail individuals in general...
- Role of Merg1, a K+ Channel in the Onset of Skeletal Muscle AtrophyAmber L Pond; Fiscal Year: 2011..Relevance. Skeletal muscle atrophy occurs with many pathological conditions (e.g., AIDS, diabetes, cancer cachexia, etc.) and is related to increased disability, morbidity and mortality...
- CYCLOPENTANNELATION IN TOTAL SYNTHESISMARCUS ANTONIUS TIUS; Fiscal Year: 2010..In tumor cells IL-6 stimulates cell proliferation and is also associated with cachexia. Selective inhibition of IL-6 could offer a new treatment for cancer...
- A Proteomic Screen for Muscle E3 LigaseSubstrates in Cachexia.IRMA SANCHEZ; Fiscal Year: 2012..aspect of cancer has proven enigmatic, as the molecular details of the protein degradation programs underlying cachexia have not been elucidated...
- Parabrachial-Forebrain Interactions in Conditioned Taste AversionSTEPHEN REILLY; Fiscal Year: 2013..For instance, cancer patients oftentimes develop strong aversions to their diets (leading to anorexia and cachexia) because the aversive visceral side effects of chemotherapy are associated with the foods consumed before ..
- Parabrachial-Forebrain Interactions in Conditioned Taste AversionSTEPHEN REILLY; Fiscal Year: 2009..For instance, cancer patients oftentimes develop strong aversions to their diets (leading to anorexia and cachexia) because the aversive visceral side effects of chemotherapy are associated with the foods consumed before ..
- Molecular Imaging of Cancer CachexiaZaver M Bhujwalla; Fiscal Year: 2010One of the most under explored and yet devastating consequences of cancer is cachexia, a condition in which the body is consumed by deranged carbohydrate, lipid and protein metabolism induced by inflammatory cytokines secreted ..
- MEGESTROL ACETATE FOR TREATMENT OF CANCER CACHEXIADavid Heber; Fiscal Year: 1992..These studies should provide critical information in understanding the action of this promising new approach to this important clinical problem...
- RECYCLING OF UREA NITROGEN IN CANCER CACHEXIABruce Patterson; Fiscal Year: 1999..Urea N recycling has not thus far been examined in the protein catabolic state associated with cancer cachexia, a condition characterized by progressive muscle protein loss resulting from altered protein metabolism, chronic ..
- Interleukin-6 Expression and Function in Adipose CellsJianbei Deng; Fiscal Year: 2006Elevated interleukin-6 (IL-6) is associated with fat wasting in systemic infection and cancer cachexia. However, important new data indicates that circulating IL-6 is also elevated in human obesity, and adipose tissue is the principal ..
- HUMAN LYMPHOCYTE PRODUCTION OF TUMOR NECROSIS FACTORSun Sang Sung; Fiscal Year: 1993..necrosis factor (TNF) is important in inducing a number of abnormal physiological conditions such as shock and cachexia. In the immune system, it promotes B and T cell proliferation, inhibits the colony formation of hematopoietic ..
- Role of IL-4 During Acute SchistosomiasisElisabeth Patton; Fiscal Year: 2002..mansoni infection. These animals are unable to mount a Th2 response and suffer from debilitating cachexia and enhanced mortality subsequent to the onset of egg production...
- Liver Derived Microparticles In Cirhossis PathogenesisRAFAL WITEK; Fiscal Year: 2009..contribute to the multiple, extra-hepatic manifestations of cirrhosis, including cutaneous spider telangectases, cachexia, increased intestinal permeability, ascites and the hepatorenal syndrome, the portopulmonary syndrome, and ..
- ALCOHOL, NUTRITION, AND IMMUNOMODULATIONCraig McClain; Fiscal Year: 2000..are great similarities between the metabolic abnormalities/complications of AIDS and ALD including anorexia, cachexia, immune suppression, hypoalbuminemia, increased acute phase reactants and edema, to name only a few...