weight loss


Summary: Decrease in existing BODY WEIGHT.

Top Publications

  1. ncbi Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study
    Stavros N Karamanakos
    Nutrition Support and Morbid Obesity Unit, Department of Surgery, University of Patras School of Medicine, Patras, Greece
    Ann Surg 247:401-7. 2008
  2. ncbi Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial
    Laura P Svetkey
    Division of Nephrology, Department of Medicine, Duke Hypertension Center and Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    JAMA 299:1139-48. 2008
  3. ncbi Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity
    J Smith
    Institut Universitaire de Cardiologie et Pneumologie de Québec, Laval University, Quebec, Canada
    J Clin Endocrinol Metab 94:4275-83. 2009
  4. pmc Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    Kittichai Promrat
    Division of Gastroenterology and Hepatology, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Hepatology 51:121-9. 2010
  5. pmc Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
    Aliki Kosteli
    Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    J Clin Invest 120:3466-79. 2010
  6. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
  7. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
  8. pmc Bariatric surgery versus intensive medical therapy in obese patients with diabetes
    Philip R Schauer
    Bariatric and Metabolic Institute, Cleveland Clinic M61, 9500 Euclid Ave, Cleveland, OH 44195, USA
    N Engl J Med 366:1567-76. 2012
  9. ncbi Bariatric surgery: a systematic review and meta-analysis
    Henry Buchwald
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    JAMA 292:1724-37. 2004
  10. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010

Detail Information

Publications298 found, 100 shown here

  1. ncbi Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study
    Stavros N Karamanakos
    Nutrition Support and Morbid Obesity Unit, Department of Surgery, University of Patras School of Medicine, Patras, Greece
    Ann Surg 247:401-7. 2008
    Bariatric surgery is currently the most effective treatment in morbidly obese patients, leading to durable weight loss.
  2. ncbi Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial
    Laura P Svetkey
    Division of Nephrology, Department of Medicine, Duke Hypertension Center and Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    JAMA 299:1139-48. 2008
    Behavioral weight loss interventions achieve short-term success, but re-gain is common.
  3. ncbi Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity
    J Smith
    Institut Universitaire de Cardiologie et Pneumologie de Québec, Laval University, Quebec, Canada
    J Clin Endocrinol Metab 94:4275-83. 2009
    ..bariatric surgery (AMS) compared with those in children born before maternal surgery (BMS), we tested the hypothesis that significant maternal weight loss may modify obesity-related factors transmitted via the intrauterine environment.
  4. pmc Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    Kittichai Promrat
    Division of Gastroenterology and Hepatology, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Hepatology 51:121-9. 2010
    ..497, P = 0.007). Participants who achieved the study weight loss goal (>or=7%), compared with those who lost less than 7%, had significant improvements in steatosis (-1...
  5. pmc Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
    Aliki Kosteli
    Department of Medicine, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    J Clin Invest 120:3466-79. 2010
    ..Here we characterized the response of adipose tissue macrophages (ATMs) to weight loss and fasting in mice and identified a role for lipolysis in ATM recruitment and accumulation...
  6. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  7. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
    ..Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high risk for the disease is not known...
  8. pmc Bariatric surgery versus intensive medical therapy in obese patients with diabetes
    Philip R Schauer
    Bariatric and Metabolic Institute, Cleveland Clinic M61, 9500 Euclid Ave, Cleveland, OH 44195, USA
    N Engl J Med 366:1567-76. 2012
    ..Observational studies have shown improvement in patients with type 2 diabetes mellitus after bariatric surgery...
  9. ncbi Bariatric surgery: a systematic review and meta-analysis
    Henry Buchwald
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    JAMA 292:1724-37. 2004
    ..About 5% of the US population is morbidly obese. This disease remains largely refractory to diet and drug therapy, but generally responds well to bariatric surgery...
  10. pmc Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial
    Rena R Wing
    Department of Psychiatry, The Miriam Hospital Brown Medical School, Providence, RI 02860, USA
    Arch Intern Med 170:1566-75. 2010
    ..We examined the effects of lifestyle intervention on changes in weight, fitness, and CVD risk factors during a 4-year study...
  11. ncbi Bariatric surgery versus conventional medical therapy for type 2 diabetes
    Geltrude Mingrone
    Department of Internal Medicine, Universita Cattolica S Cuore, Largo A Gemelli 8, 00168 Rome, Italy
    N Engl J Med 366:1577-85. 2012
    ..Prospective, randomized trials comparing these procedures with medical therapy for the treatment of diabetes are needed...
  12. ncbi Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
    Lars Sjöström
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    N Engl J Med 351:2683-93. 2004
    b>Weight loss is associated with short-term amelioration and prevention of metabolic and cardiovascular risk, but whether these benefits persist over time is unknown.
  13. ncbi Effects of bariatric surgery on mortality in Swedish obese subjects
    Lars Sjöström
    Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
    N Engl J Med 357:741-52. 2007
    Obesity is associated with increased mortality. Weight loss improves cardiovascular risk factors, but no prospective interventional studies have reported whether weight loss decreases overall mortality...
  14. ncbi Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical
    Paul Poirier
    Circulation 113:898-918. 2006
    ..In this statement, we review the available evidence of the impact of obesity on CVD with emphasis on the evaluation of cardiac structure and function in obese patients and the effect of weight loss on the cardiovascular system.
  15. pmc FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
    Joo Young Huh
    Division of Endocrinology, Diabetes, and Metabolism, BethIsrael Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 61:1725-38. 2012
    ..No prior study has reported on the physiological regulation and role of circulating irisin and FNDC5 in humans...
  16. ncbi Effectiveness of web-based interventions in achieving weight loss and weight loss maintenance in overweight and obese adults: a systematic review with meta-analysis
    M Neve
    School of Health Sciences, Faculty of Health, The University of Newcastle, Newcastle, NSW, Australia
    Obes Rev 11:306-21. 2010
    The objectives of this systematic review are to evaluate the effectiveness of web-based interventions on weight loss and maintenance and identify which components of web-based interventions are associated with greater weight change and ..
  17. pmc Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials
    Tina Vilsbøll
    Diabetes Research Division, Department of Internal Medicine F, Gentofte Hospital, University of Copenhagen, DK 2900 Hellerup, Denmark
    BMJ 344:d7771. 2012
    To determine whether treatment with agonists of glucagon-like peptide-1 receptor (GLP-1R) result in weight loss in overweight or obese patients with or without type 2 diabetes mellitus.
  18. ncbi Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss
    Carl J Lavie
    Cardiac Rehabilitation, Exercise Laboratories, Ochsner Medical Center, New Orleans, Louisiana 70121 2483, USA
    J Am Coll Cardiol 53:1925-32. 2009
  19. pmc Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes
    Rena R Wing
    Department of Psychiatry and Human Behavior, Brown Medical School, The Miriam Hospital, Providence, Rhode Island, USA
    Diabetes Care 34:1481-6. 2011
    ..Overweight and obese individuals are encouraged to lose 5-10% of their body weight to improve cardiovascular disease (CVD) risk, but data supporting this recommendation are limited, particularly for individuals with type 2 diabetes...
  20. pmc Comparison of range of commercial or primary care led weight reduction programmes with minimal intervention control for weight loss in obesity: lighten Up randomised controlled trial
    Kate Jolly
    School of Health and Population Sciences, University of Birmingham, Birmingham B15 2TT, UK
    BMJ 343:d6500. 2011
    To assess the effectiveness of a range of weight management programmes in terms of weight loss.
  21. pmc Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
    Jean Pierre Furet
    French National Institute for Agricultural Research, U910, Unité d Ecologie et de Physiologie du Système Digestif, Jouy en Josas, France
    Diabetes 59:3049-57. 2010
    ..RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity resulting in drastic weight loss and improvement of metabolic and inflammatory status...
  22. ncbi Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up
    Marion J Franz
    Nutrition Concepts by Franz, Inc, Minneapolis, MN 55439, USA
    J Am Diet Assoc 107:1755-67. 2007
  23. pmc Comparative effectiveness of weight-loss interventions in clinical practice
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    N Engl J Med 365:1959-68. 2011
    Obesity and its cardiovascular complications are extremely common medical problems, but evidence on how to accomplish weight loss in clinical practice is sparse.
  24. pmc Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
    Frank M Sacks
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 360:859-73. 2009
    The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year.
  25. ncbi Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial
    Lawrence J Appel
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md 21205 2233, USA
    JAMA 289:2083-93. 2003
    b>Weight loss, sodium reduction, increased physical activity, and limited alcohol intake are established recommendations that reduce blood pressure (BP). The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP...
  26. ncbi Long-term persistence of hormonal adaptations to weight loss
    Priya Sumithran
    Department of Medicine Austin and Northern Health, University of Melbourne, Melbourne, Vic, Australia
    N Engl J Med 365:1597-604. 2011
    After weight loss, changes in the circulating levels of several peripheral hormones involved in the homeostatic regulation of body weight occur...
  27. ncbi Long-term weight loss maintenance
    Rena R Wing
    Brown Medical School, The Miriam Hospital, Department of Psychiatry, Providence, RI, USA
    Am J Clin Nutr 82:222S-225S. 2005
    There is a general perception that almost no one succeeds in long-term maintenance of weight loss. However, research has shown that approximately 20% of overweight individuals are successful at long-term weight loss when defined as ..
  28. ncbi A self-regulation program for maintenance of weight loss
    Rena R Wing
    Brown Medical School, Providence, RI, USA
    N Engl J Med 355:1563-71. 2006
    ..We developed a maintenance program based on self-regulation theory and tested the efficacy of delivering the program face to face or over the Internet...
  29. pmc Effect of weight loss with lifestyle intervention on risk of diabetes
    Richard F Hamman
    Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes Care 29:2102-7. 2006
    ..We explored the contribution of changes in weight, diet, and physical activity on the risk of developing diabetes among ILS participants...
  30. pmc Diets with high or low protein content and glycemic index for weight-loss maintenance
    Thomas Meinert Larsen
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    N Engl J Med 363:2102-13. 2010
    ..Studies of weight-control diets that are high in protein or low in glycemic index have reached varied conclusions, probably owing to the fact that the studies had insufficient power...
  31. ncbi Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery
    David E Cummings
    Department of Medicine, University of Washington the Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    N Engl J Med 346:1623-30. 2002
    b>Weight loss causes changes in appetite and energy expenditure that promote weight regain. Ghrelin is a hormone that increases food intake in rodents and humans...
  32. pmc Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial
    Susan A Jebb
    MRC Human Nutrition Research, Cambridge, UK
    Lancet 378:1485-92. 2011
    The increasing prevalence of overweight and obesity needs effective approaches for weight loss in primary care and community settings...
  33. pmc Weight loss, exercise, or both and physical function in obese older adults
    Dennis T Villareal
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, USA
    N Engl J Med 364:1218-29. 2011
    ..Obesity exacerbates the age-related decline in physical function and causes frailty in older adults; however, the appropriate treatment for obese older adults is controversial...
  34. pmc Lifestyle intervention for prevention of type 2 diabetes in primary health care: one-year follow-up of the Finnish National Diabetes Prevention Program (FIN-D2D)
    Timo Saaristo
    Pirkanmaa Hospital District, Tampere, Finland
    Diabetes Care 33:2146-51. 2010
    ..To investigate 1-year outcomes of a national diabetes prevention program in Finland...
  35. pmc Roux-en-Y gastric bypass enhances energy expenditure and extends lifespan in diet-induced obese rats
    Nicholas Stylopoulos
    Gastrointestinal Unit and MGH Weight Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1839-47. 2009
    ..Despite its widespread clinical use, the mechanisms by which RYGB induces its profound weight loss remain largely unknown...
  36. pmc Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, MUH N810, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    JAMA 304:1795-802. 2010
  37. ncbi The continuing epidemics of obesity and diabetes in the United States
    A H Mokdad
    Data Management Division, National Immunization Program, Centers for Disease Control and Prevention, MS E62, 1600 Clifton Rd, NE, Atlanta, GA 30333, USA
    JAMA 286:1195-200. 2001
    ..Recent reports show that obesity and diabetes have increased in the United States in the past decade...
  38. pmc A two-year randomized trial of obesity treatment in primary care practice
    Thomas A Wadden
    Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    N Engl J Med 365:1969-79. 2011
    ..This randomized trial compared weight loss during a 2-year period in response to three lifestyle interventions, all delivered by PCPs in collaboration ..
  39. ncbi The effects of high protein diets on thermogenesis, satiety and weight loss: a critical review
    Thomas L Halton
    Dept of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Am Coll Nutr 23:373-85. 2004
    For years, proponents of some fad diets have claimed that higher amounts of protein facilitate weight loss. Only in recent years have studies begun to examine the effects of high protein diets on energy expenditure, subsequent energy ..
  40. pmc Self-monitoring in weight loss: a systematic review of the literature
    Lora E Burke
    School of Nursing and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Am Diet Assoc 111:92-102. 2011
    Self-monitoring is the centerpiece of behavioral weight loss intervention programs...
  41. ncbi Interplay between weight loss and gut microbiota composition in overweight adolescents
    Arlette Santacruz
    Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Valencia, Spain
    Obesity (Silver Spring) 17:1906-15. 2009
    ..A group of subjects (n=23) experienced >4.0 kg weight loss and showed significant BMI (P=0.030) and BMI z-score (P=0...
  42. ncbi Who succeeds in maintaining weight loss? A conceptual review of factors associated with weight loss maintenance and weight regain
    K Elfhag
    Obesity Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Obes Rev 6:67-85. 2005
    b>Weight loss is difficult to achieve and maintaining the weight loss is an even greater challenge...
  43. pmc Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial
    Deborah F Tate
    Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7440, USA
    Am J Clin Nutr 95:555-63. 2012
    ..Replacement of caloric beverages with noncaloric beverages may be a simple strategy for promoting modest weight reduction; however, the effectiveness of this strategy is not known...
  44. pmc Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study
    W Timothy Garvey
    Department of Nutrition Sciences, UAB Diabetes Research and Training Center, University of Alabama at Birmingham, 35294 3360, USA
    Am J Clin Nutr 95:297-308. 2012
    ..phentermine/topiramate (PHEN/TPM CR), as an adjunct to lifestyle modification, has previously shown significant weight loss compared with placebo in a 56-wk study in overweight and obese subjects with ≥2 weight-related comorbidities.
  45. ncbi Male inclusion in randomized controlled trials of lifestyle weight loss interventions
    Sherry L Pagoto
    Department of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Obesity (Silver Spring) 20:1234-9. 2012
    The prevalence of obesity is similar for men (32.2%) and women (35.5%). It has been assumed that lifestyle weight loss interventions have been developed and tested in predominately female samples, but this has not been systematically ..
  46. pmc A text message-based intervention for weight loss: randomized controlled trial
    Kevin Patrick
    Department of Family and Preventive Medicine, California Institute of Telecommunications and Information Technology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0811, USA
    J Med Internet Res 11:e1. 2009
    To our knowledge, no studies have evaluated whether weight loss can be promoted in overweight adults through the use of an intervention that is largely based on daily SMS (Short Message Service: text) and MMS (Multimedia Message Service: ..
  47. ncbi Efficacy of a workplace-based weight loss program for overweight male shift workers: the Workplace POWER (Preventing Obesity Without Eating like a Rabbit) randomized controlled trial
    Philip J Morgan
    School of Education, Faculty of Education and Arts, University of Newcastle, Callaghan, New South Wales, Australia
    Prev Med 52:317-25. 2011
    To evaluate the feasibility and efficacy of a workplace-based weight loss program (Workplace POWER-WP) for male shift workers.
  48. ncbi Long-term weight-loss maintenance: a meta-analysis of US studies
    J W Anderson
    VA Medical Center, Graduate Center for Nutritional Sciences, University of Kentucky Health Management Resources Weight Management Program, Lexington, KY, USA
    Am J Clin Nutr 74:579-84. 2001
    Current perception is that participants of a structured weight-loss program regain all of their weight loss within 5 y.
  49. ncbi A randomized trial comparing human e-mail counseling, computer-automated tailored counseling, and no counseling in an Internet weight loss program
    Deborah F Tate
    Schools of Public Health and Medicine, Department of Health Behavior and Health Education, University of North Carolina, Chapel Hill, NC 27599, USA
    Arch Intern Med 166:1620-5. 2006
    Several studies have shown that e-mail counseling improves weight loss achieved in self-directed Internet programs. Computer-tailored feedback offers a population-based alternative to human e-mail counseling.
  50. ncbi How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement
    W H M Saris
    Nutrition and Toxicology Research Institute, Maastricht NUTRIM, University of Maastricht, Department of Human Biology, Maastricht, The Netherlands
    Obes Rev 4:101-14. 2003
    ..Settings in which these environmental changes can be implemented include the urban and transportation infrastructure, schools, and workplaces.'..
  51. ncbi Type 2 diabetes prevention in the "real world": one-year results of the GOAL Implementation Trial
    Pilvikki Absetz
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, FI 00300 Helsinki, Finland
    Diabetes Care 30:2465-70. 2007
    ..We report on the program's effectiveness as well as findings related to the program's reach, adoption, and implementation...
  52. ncbi Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial
    S B Heymsfield
    Weight Control Unit, St Luke s Roosevelt Hospital, New York, NY 10025, USA
    JAMA 282:1568-75. 1999
    The protein hormone leptin is important to the homeostatic regulation of body weight. Treatment with exogenous leptin may affect weight loss.
  53. ncbi 12-month outcomes and process evaluation of the SHED-IT RCT: an internet-based weight loss program targeting men
    Philip J Morgan
    School of Education, Faculty of Education and Arts, University of Newcastle, Callaghan, New South Wales, Australia
    Obesity (Silver Spring) 19:142-51. 2011
    ..evaluation of the SHED-IT (Self-Help, Exercise, and Diet using Information Technology) trial, an Internet-based weight loss program exclusively for men...
  54. pmc Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    J Fruebis
    Genset Corporation, Functional Genomics, 875 Prospect Street, No. 206, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:2005-10. 2001
    ..Thus, gAcrp30 is a novel pharmacological compound that controls energy homeostasis and exerts its effect primarily at the peripheral level...
  55. ncbi Long-term mortality after gastric bypass surgery
    Ted D Adams
    Cardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    N Engl J Med 357:753-61. 2007
  56. ncbi Obesity and health-related quality of life
    K R Fontaine
    Division of Gerontology, Department of Medicine, University of Maryland School of Medicine, Geriatric Research Education and Clinical Center GRECC, Baltimore VA Medical Center, Baltimore, MD, USA
    Obes Rev 2:173-82. 2001
  57. ncbi Translating the Diabetes Prevention Program: a comprehensive model for prevention training and program delivery
    M Kaye Kramer
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15213, USA
    Am J Prev Med 37:505-11. 2009
    ..A universal framework for translation of multiple aspects of the DPP intervention, including training, support, and evaluation is needed to enhance treatment fidelity in a variety of settings...
  58. ncbi A review and meta-analysis of the effect of weight loss on all-cause mortality risk
    Mary Harrington
    The Sugar Bureau, London WC2B 5JJ, UK
    Nutr Res Rev 22:93-108. 2009
    ..It is less clear whether weight loss benefits longevity and hence whether weight reduction is justified as a prime goal for all individuals who are ..
  59. pmc Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss
    S H Shah
    Department of Medicine, DUMC, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Diabetologia 55:321-30. 2012
    Insulin resistance (IR) improves with weight loss, but this response is heterogeneous. We hypothesised that metabolomic profiling would identify biomarkers predicting changes in IR with weight loss.
  60. pmc Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial
    Ikuyo Imayama
    Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 72:2314-26. 2012
    ..We examined the effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in 439 women...
  61. ncbi The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat
    C Martins
    Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    J Clin Endocrinol Metab 95:1609-16. 2010
    The magnitude of exercise-induced weight loss depends on the extent of compensatory responses...
  62. pmc Using mHealth technology to enhance self-monitoring for weight loss: a randomized trial
    Lora E Burke
    Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania 15261, USA
    Am J Prev Med 43:20-6. 2012
    Self-monitoring for weight loss has traditionally been performed with paper diaries. Technologic advances could reduce the burden of self-monitoring and provide feedback to enhance adherence.
  63. pmc Weight loss treatment influences untreated spouses and the home environment: evidence of a ripple effect
    A A Gorin
    Department of Psychology, Center for Health, Intervention and Prevention, University of Connecticut, Storrs, CT, USA
    Int J Obes (Lond) 32:1678-84. 2008
    To examine whether a weight loss program delivered to one spouse has beneficial effects on the untreated spouse and the home environment.
  64. ncbi Human colonic microbiota associated with diet, obesity and weight loss
    S H Duncan
    Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen, UK
    Int J Obes (Lond) 32:1720-4. 2008
    ..It has been proposed that the development of obesity in humans is influenced by the relative proportions of the two major phyla of bacteria (Bacteroidetes and Firmicutes) present in the large intestine...
  65. ncbi Systematic review: an evaluation of major commercial weight loss programs in the United States
    Adam Gilden Tsai
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Intern Med 142:56-66. 2005
    Each year millions of Americans enroll in commercial and self-help weight loss programs. Health care providers and their obese patients know little about these programs because of the absence of systematic reviews.
  66. pmc Dropout, nonusage attrition, and pretreatment predictors of nonusage attrition in a commercial Web-based weight loss program
    Melinda J Neve
    School of Health Sciences, Faculty of Health, The University of Newcastle, Callaghan, Australia
    J Med Internet Res 12:e69. 2010
    ..of the factors that predict retention and website use are critical to the development of effective Web-based weight loss interventions...
  67. pmc Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
    N Deblon
    Department of Internal Medicine, University of Geneva, Geneva, Switzerland
    Br J Pharmacol 165:2325-40. 2012
    ..Here, we investigated the mechanisms associated with the diabetogenic effects of chronic Sirolimus administration in rats and in in vitro cell cultures...
  68. pmc Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus
    Philip R Schauer
    Departments of Surgery, University of Pittsburg, Pittsburgh, PA, USA
    Ann Surg 238:467-84; discussion 84-5. 2003
    ..To evaluate pre- and postoperative clinical parameters associated with improvement of diabetes up to 4 years after laparoscopic Roux-en-Y gastric bypass (LRYGBP) in patients with type 2 diabetes mellitus (T2DM)...
  69. pmc The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it
    Thomas A Wadden
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA corrected
    Obesity (Silver Spring) 14:737-52. 2006
    ..in Diabetes) study is a multicenter, randomized controlled trial designed to determine whether intentional weight loss reduces cardiovascular morbidity and mortality in overweight individuals with type 2 diabetes...
  70. ncbi Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years
    John G Kral
    Department of Surgery, Box 40, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Pediatrics 118:e1644-9. 2006
    ..172 children who were aged 2 to 18 years and born to 113 obese mothers (BMI: 31 +/- 9 kg/m2) with substantial weight loss after biliopancreatic bypass surgery with 45 same-age siblings who were born before maternal surgery (mothers' ..
  71. ncbi Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Found
    Samuel Klein
    Circulation 110:2952-67. 2004
    ..Modest weight loss can improve diastolic function and affect the entire cluster of coronary heart disease risk factors ..
  72. ncbi A review of psychosocial pre-treatment predictors of weight control
    P J Teixeira
    Department of Exercise and Health, Faculty of Human Movement, Technical University of Lisbon, Lisbon, Portugal
    Obes Rev 6:43-65. 2005
    ..Identifying significant predictors of weight loss outcomes is central to improving treatments for obesity, as it could help professionals focus efforts on those ..
  73. ncbi Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
    Armin Zittermann
    Klinik für Thorax und Kardiovaskularchirurgie and Institut für Laboratoriums und Transfusionsmedizin, Herzzentrum NRW, Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Am J Clin Nutr 89:1321-7. 2009
    ..However, there is also evidence that calcitriol increases lipogenesis and decreases lipolysis...
  74. pmc Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults
    Jill A Parnell
    Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Am J Clin Nutr 89:1751-9. 2009
    Rodent studies show that oligofructose promotes weight loss, stimulates satiety hormone secretion, reduces energy intake, and improves lipid profiles.
  75. ncbi The defence of body weight: a physiological basis for weight regain after weight loss
    Priya Sumithran
    Department of Medicine, University of Melbourne, Australia
    Clin Sci (Lond) 124:231-41. 2013
    Although weight loss can usually be achieved by restricting food intake, the majority of dieters regain weight over the long-term...
  76. ncbi Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
    J P Bastard
    Service de Biochimie, Hopital de la Salpetriere, Paris, France
    J Clin Endocrinol Metab 85:3338-42. 2000
    ..VLCD resulted in weight loss and decreased body fat mass (approximately 3 kg)...
  77. pmc Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy
    Eric Ravussin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 17:1736-43. 2009
    ..diet-induced obese (DIO) rodents, amylin/leptin combination treatment led to marked, synergistic, fat-specific weight loss. To evaluate the weight-lowering effect of combined amylin/leptin agonism (with pramlintide/metreleptin) in ..
  78. ncbi A review of laparoscopic sleeve gastrectomy for morbid obesity
    Xinzhe Shi
    Centre for Advancement of Minimally Invasive Surgery CAMIS, Royal Alexandra Hospital, 10240 Kingsway Ave, Edmonton, AB T5H 3V9, Canada
    Obes Surg 20:1171-7. 2010
    Laparoscopic sleeve gastrectomy (LSG) is an innovative approach to the surgical management of morbid obesity. Weight loss may be achieved by restrictive and endocrine mechanisms...
  79. ncbi Dietary protein, weight loss, and weight maintenance
    M S Westerterp-Plantenga
    Department of Human Biology, NUTRIM, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Annu Rev Nutr 29:21-41. 2009
    The role of dietary protein in weight loss and weight maintenance encompasses influences on crucial targets for body weight regulation, namely satiety, thermogenesis, energy efficiency, and body composition...
  80. ncbi Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
    ..Injections of wild-type mice twice daily with the mouse protein resulted in a sustained 12 percent weight loss, decreased food intake, and a reduction of body fat from 12.2 to 0.7 percent...
  81. ncbi Efficacy and safety of topiramate in the treatment of obese subjects with essential hypertension
    Serena Tonstad
    University of Oslo, Oslo, Norway
    Am J Cardiol 96:243-51. 2005
    ..In conclusion, topiramate produced clinically relevant effects in reducing body weight and BP, with generally mild to moderate adverse effects...
  82. pmc Financial incentive-based approaches for weight loss: a randomized trial
    Kevin G Volpp
    Center for Health Equity Research and Promotion, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    JAMA 300:2631-7. 2008
    ..Identifying effective obesity treatment is both a clinical challenge and a public health priority due to the health consequences of obesity...
  83. ncbi Drug treatments for obesity: orlistat, sibutramine, and rimonabant
    Raj S Padwal
    Department of Medicine, University of Alberta Hospital, Edmonton, AB, Canada
    Lancet 369:71-7. 2007
    ..new drugs are developed we suggest that the assessment processes should include both surrogate endpoints (ie, weight loss) and clinical outcomes (ie, major obesity-related morbidity and mortality)...
  84. ncbi Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial
    Joanna McMillan-Price
    Human Nutrition Unit, University of Sydney, Sydney, Australia
    Arch Intern Med 166:1466-75. 2006
    Despite the popularity of low-glycemic index (GI) and high-protein diets, to our knowledge no randomized, controlled trials have systematically compared their relative effects on weight loss and cardiovascular risk.
  85. pmc Design and dissemination of the MOVE! Weight-Management Program for Veterans
    Linda S Kinsinger
    VHA National Center for Health Promotion and Disease Prevention, 3022 Croasdaile Dr, Ste 200, Durham, NC 27705, USA
    Prev Chronic Dis 6:A98. 2009
    ..Practitioners in the Veterans Health Administration (VHA) identified comprehensive weight management as a high priority in early 2001...
  86. pmc Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life
    I J Hickman
    School of Medicine, University of Queensland, and Department of Nutrition and Dietetic Services, Princess Alexandra Hospital, Brisbane, Australia
    Gut 53:413-9. 2004
    ..The aim of this study was to investigate the longer term effect of weight loss on liver biochemistry, serum insulin levels, and quality of life in overweight patients with liver disease and ..
  87. ncbi Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials
    Judith E Neter
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Hypertension 42:878-84. 2003
    ..43 to -0.66) systolic and -0.92 mm Hg (95% CI, -1.28 to -0.55) diastolic when expressed per kilogram of weight loss. As expected, significantly larger blood pressure reductions were observed in populations with an average ..
  88. ncbi Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    L Blonde
    Ochsner Clinic Foundation, New Orleans, LA, USA
    Diabetes Obes Metab 8:436-47. 2006
    ..This analysis examined the effects of exenatide on glycaemic control and weight over an 82-week period in patients with DM2 unable to achieve adequate glycaemic control with sulphonylurea (SU) and/or metformin (MET)...
  89. pmc Utilization patterns and user characteristics of an ad libitum Internet weight loss program
    Martin Binks
    Binks Behavioral Health PLLC, 2801 Canter Drive, Hillsborough, NC 27278, USA
    J Med Internet Res 12:e9. 2010
    The Internet holds promise for the delivery of evidence-based weight loss treatment to underserved populations. However, most studies do not reflect the more naturalistic and common ad libitum, or freely at will, use of the Internet...
  90. pmc Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
    Carel W le Roux
    Department of Metabolic Medicine, Hammersmith Hospital, Imperial College London, UK
    Ann Surg 243:108-14. 2006
    ..To study the effect of bariatric surgery on the entero-hypothalamic endocrine axis of humans and rodents...
  91. ncbi A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial
    Meredith C Fidler
    Arena Pharmaceuticals San Diego, California 92121, USA
    J Clin Endocrinol Metab 96:3067-77. 2011
    ..Lorcaserin is a novel selective agonist of the serotonin 2C receptor...
  92. ncbi Mediators of weight loss and weight loss maintenance in middle-aged women
    Pedro J Teixeira
    Department of Exercise and Health, Faculty of Human Kinetics, Technical University of Lisbon, Lisbon, Portugal
    Obesity (Silver Spring) 18:725-35. 2010
    Long-term behavioral self-regulation is the hallmark of successful weight control. We tested mediators of weight loss and weight loss maintenance in middle-aged women who participated in a randomized controlled 12-month weight management ..
  93. ncbi Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society
    Dennis T Villareal
    Division of Geriatrics and Nutritional Sciences, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Obes Res 13:1849-63. 2005
    ..of the reduction in relative health risks associated with increasing body mass index and the concern that weight loss could have potential harmful effects in the older population...
  94. pmc Lifestyle change and mobility in obese adults with type 2 diabetes
    W Jack Rejeski
    Reynolda Campus, Wake Forest University, Winston Salem, NC 27109, USA
    N Engl J Med 366:1209-17. 2012
    Adults with type 2 diabetes mellitus often have limitations in mobility that increase with age. An intensive lifestyle intervention that produces weight loss and improves fitness could slow the loss of mobility in such patients.
  95. ncbi Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss
    Monica Sabater
    Department of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona, Instituto de Salud Carlos III, Girona, Spain
    J Clin Endocrinol Metab 95:4720-8. 2010
    ..We aimed to study circulating pigment epithelium-derived factor (PEDF) in vivo in association with insulin resistance and in vitro in human adipocytes...
  96. ncbi Meta-analysis: surgical treatment of obesity
    Melinda A Maggard
    Southern California Evidence Based Practice Center, RAND Health Division, Santa Monica, California, USA
    Ann Intern Med 142:547-59. 2005
    Controversy exists regarding the effectiveness of surgery for weight loss and the resulting improvement in health-related outcomes.
  97. ncbi Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss in humans
    Monica C Klempel
    Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Nutr Rev 69:145-54. 2011
    Calorie restriction (CR)-induced weight loss has been shown to lower the risk of chronic disease in obese individuals...
  98. pmc Responses of gut microbiota to diet composition and weight loss in lean and obese mice
    Yann Ravussin
    Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Obesity (Silver Spring) 20:738-47. 2012
    ..Gut microbiota have been implicated in the regulation of body weight. The effects of weight loss on qualitative aspects of gut microbiota have been studied in humans and mice, but these studies have been ..
  99. ncbi Catecholamine reuptake inhibition causes weight loss by increasing locomotor activity and thermogenesis
    Sonja K Billes
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, OR 97006, USA
    Neuropsychopharmacology 33:1287-97. 2008
    Bupropion (BUP) is a dopamine (DA) and norepinephrine (NE) reuptake inhibitor that causes mild weight loss in obese adults. Subchronic (7 day) coadministration of selective DA and NE reuptake inhibitors also causes weight loss in mice...
  100. pmc Missing data in randomized clinical trials for weight loss: scope of the problem, state of the field, and performance of statistical methods
    Mai A Elobeid
    Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 4:e6624. 2009
    ..Herein, we meta-analytically evaluate the extent of missing data, the frequency with which various analytic methods are employed to accommodate dropouts, and the performance of multiple statistical methods...
  101. ncbi Interventions to achieve long-term weight loss in obese older people: a systematic review and meta-analysis
    Miles D Witham
    Section of Ageing and Health, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK
    Age Ageing 39:176-84. 2010
    ..the prevalence of obesity is rapidly increasing in older adults. Information is required about what interventions are effective in reducing obesity and influencing health outcomes in this age group...

Research Grants83

    SUSAN BARTLETT; Fiscal Year: 2004
    DESCRIPTION (Taken from the applicant's abstract): Dr. Susan Bartlett has a clinical background in weight loss and exercise...
  2. Regulation of Stable Fat Loss in a Model System
    Gene E Robinson; Fiscal Year: 2010
    An important challenge in developing treatments that induce weight loss and prevent weight regain is to identify regulatory mechanisms that can be targeted for drug therapy...
  3. Telehealth delivery of a weight loss program in diabetes
    Jennifer Lovejoy; Fiscal Year: 2004
    Obesity and Type 2 diabetes are emerging epidemics in the U.S. Weight loss improves diabetes outcomes and reduces the need for anti-diabetic medication...
  4. A Culturally-Tailored Weight Loss Program
    Michael Simon; Fiscal Year: 2005
    ..This proposal seeks to develop a culturally-tailored weight loss intervention for obese AA breast cancer survivors who have been free of recurrence...
  5. Obesity, Body Image and Weight Maintenance
    DAVID SARWER; Fiscal Year: 2005
    ..The great majority of obese persons, however, regain at least one-third of their weight loss in the year following treatment...
  6. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..Candidate: Since graduate school, I have been interested in the homeostatic mechanisms that operate against weight loss for obese and diabetic individuals...
  7. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..such as modifed alternate-day fasting (mADF) reproduce many of the benefits of true CR in mice, without weight loss or change in body composition...
    Michael J LaMonte; Fiscal Year: 2013
    ..Physical activity and weight loss ameliorate risk of certain Metsyn-related complications, but it is unknown if this extends to periodontal ..
  9. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..5 million individuals in the US are diagnosed with cancer. Cachexia, defined as an involuntary weight loss >5%, is present in up to 80% of these patients and it encompasses the loss of muscle and fat mass...
    Maureen J Charron; Fiscal Year: 2010
    ..fat IU offspring to diets that alter body weight and metabolism including a high fat diabetogenic diet or a weight loss ketogenic diet during their adult life...
  11. Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats
    Haifei Shi; Fiscal Year: 2010
    ..of energy homeostasis suggests the potential need for gender-specific strategies to produce therapeutic weight loss. The role of altered energy intake and expenditure and the underlying mechanism of sex differences in energy ..
  12. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..with telomere shortening, but there is a lack of research on 1) the independent and combined effects of dietary weight loss and exercise on telomere length and 2) the amount of weight loss, or change in body composition that may be ..
  13. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..that alter insulin sensitivity including short-term very low calorie diet, after stabilization following 10% weight loss, and insulin-sensitizing thiazolidinedione treatment...
    Jessica A Whiteley; Fiscal Year: 2011
    ..Given the rapidly growing prevalence of obesity in youths, developing evidence-based weight loss treatments that not only achieve weight loss but facilitate sustainability of healthy weight are needed, ..
  15. Thyroid Hormone Action
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..we have found that 2-week daily dosing of T1AM with doses approaching the 5g/kg range lead to significant weight loss in diet-induced obese mice...
  16. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..Examine blood monocyte activation, including CD11c expression, in obese mice and humans;and its modulation by weight loss and by dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA);Aim 2...
  17. Role of leptin-mediated PI3 Kinase signaling on reproductive control
    Carol Fuzeti Elias; Fiscal Year: 2013
    ..ob/ob) or resistant (db/db) to leptin are infertile, and leptin administration to ob/ob mice, but not weight loss alone, restores their fertility...
  18. Metabolic Adapation and Control of Lactation in Humans
    Morey W Haymond; Fiscal Year: 2010
    ..that control milk production will result in improved success in lactation and appropriate methods to sustain weight loss while maintaining appropriate milk production in lactating women who have gained excessive weight during ..
  19. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..ob/ob mice indicate marked improvement in key parameters associated with enhanced insulin sensitivity including weight loss, improved hepatic histology and loss of hepatic steatosis, and reduced thiobarbituric acid reactive substances (..
  20. Mechanistic Studies on Prostate Cancer Prevention by Gugulipid
    Dong Xiao; Fiscal Year: 2013
    ..cancer incidence and progression in transgenic adenocarcinoma of mouse prostate (TRAMP) mice without causing weight loss or any other side effects...
  21. Obesity: neural control of body weight and metabolism
    Barry E Levin; Fiscal Year: 2013
    ..such genetically predisposed individuals become obese, there is less than a 10% chance of producing permanent weight loss using medical interventions...
  22. Effects of Gastric Bypass Surgery on Calcium Metabolism and the Skeleton
    ANNE LOUISE SCHAFER; Fiscal Year: 2013
    ..investigator in patient-oriented clinical research involving the cross-disciplinary fields of obesity, surgical weight loss, and bone metabolism. Obesity is a chronic disease of staggering proportions...
  23. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..information and foods that are pertinent to this population, with a focus on modifying the South Asian diet for weight loss, portion control, and making healthy food choices...
    Domenico Accili; Fiscal Year: 2013
    ..E (Cpe) as a Foxo1 target, providing insight into the pathophysiology of the recidivism of obesity following weight loss;iv, identification of acetylation-based mechanisms of regulation of Foxo1 function by nutrients, and their ..
  25. Hypothalamic SIRT1 and Energy Balance
    Eduardo A Nillni; Fiscal Year: 2013
    ..Obesity treatment strategies often do not result in adequate sustained weight loss, and the prevalence and severity of obesity in the U.S. and many other countries is progressively increasing...
  26. Comparative Effectiveness of Medical Therapy vs. Bariatric Surgery for Obese T2DM
    DAVID BRADLEY contact LAUTZ; Fiscal Year: 2010
    ..Patients with T2DM undergoing bariatric surgical procedures demonstrate substantial and sustained weight loss, reductions in diabetes medications in 84%, and remission of hyperglycemia in 77% [2]...
  27. PKC delta and cell renewal in irradiated taste epithelium
    MARY ELAINE REYLAND; Fiscal Year: 2012
    ..Importantly, patients with reduced taste sensation tend to lack appetite and eat far less, leading to weight loss, as well as a significantly compromised quality of life...
  28. The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2013
    ..leads to suppressed hepatic and adipose 112-HSD1 activity that may contribution to insulin sensitivity and weight loss in a high- fat diet model of obesity...
  29. K-Mg-citrate as a BP lowering agent in African Americans; role of natriuresis
    ROBERT FRANKLIN REILLY; Fiscal Year: 2010
    ..approaches, comprised of lifestyle modifications such as exercise, reduction in alcohol consumption, weight loss, and dietary manipulation are accepted as first line management of stage I hypertension...
  30. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..One potential option to reduce these risks is to promote weight loss in older adults...
  31. Nutrition and Anabolic Interventions in Cancer Cachexia
    Melinda Sheffield-Moore; Fiscal Year: 2013
    ..Results from this study may lead to better ways of preventing cancer-related weight loss, and improve the quality of life and survival of those affected by cervical cancer.
    CLAIRE L MURPHY; Fiscal Year: 2013
    ..While frailty and weight loss in the elderly are poor prognostic factors for debility and mortality, epidemic increase in middle-aged obesity ..
  33. Prostaglandin signaling following seizures
    Jianxiong Jiang; Fiscal Year: 2013
    ..status epilepticus in mice provides many beneficial effects including reductions in mortality, weight loss, functional loss, neuroinflammation and neurodegeneration...
  34. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..complications of diabetic mellitus in clinics and can cause disabling symptoms including nausea, vomiting and weight loss and often leads to delayed or accelerated gastric emptying...
  35. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    ..whole body metabolism and weight changes in response to acute fasting/refeeding or longterm diet-induced weight loss. Knowledge gained from these studies will provide important information regarding the benefits or risks of GH ..
  36. RYGB Improves Metabolism by Interrupting the Gastric Adipose Tissue Axis
    Naji N Abumrad; Fiscal Year: 2013
    ..Roux-en-Y gastric bypass (RYGB) surgery is the most effective and sustainable weight loss procedure...
  37. Remodeling of Lipid Metabolism by Dietary Methionine Restriction
    ERIC PAUL PLAISANCE; Fiscal Year: 2012
    ..Lifestyle modifications producing weight loss improves biomarkers of metabolic syndrome, but the high rate of recidivism with these strategies has prompted ..
  38. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..Animals will be monitored for body weight and clinical signs of illness: hunched-over appearance, weight loss, loose stools/diarrhea, and bloody stools...
  39. Neuroendocrine Response to Gastric Bypass in Nonhuman Primates
    Randy J Seeley; Fiscal Year: 2010
    ..Among the current therapies for obesity, bariatric or gastrointestinal weight loss surgery (GIWLS) generally, and Roux-en-Y gastric bypass (RYGB) in particular, has proven to be the most ..
  40. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    ..g. weight loss) to increase their quality of life...
  41. Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor Patients
    Raymond P Perez; Fiscal Year: 2010
    ..Conjugated linoleic acid (CLA) is a safe, popular, and well-tolerated dietary supplement that promotes weight loss and loss of fat...
  42. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Weight loss for overweight and obese individuals is recommended for cancer prevention;however, weight loss, particularly in older adults, can cause deleterious accelerated bone and muscle loss...
  43. Predictors of Immunologic Failure in Older Adults
    David H Canaday; Fiscal Year: 2012
    ..The criteria of measuring a Frailty Index include: unintentional weight loss, exhaustion, loss of strength, slow walking speed, and low level of activity...
  44. Treatment of Hyperandrogenism vs. Insulin Resistance in Infertile PCOS Women
    Richard S Legro; Fiscal Year: 2012
    ..PCOS is to correct HA, and the key to avoiding later pregnancy complications is to improve IR with an intense weight loss program. Phase I will be a randomized trial of three preconception interventions (lasting 4 mos...
  45. Extending Sleep in Obese Adults to Promote Weight Loss
    Ann E Rogers; Fiscal Year: 2010
    ..It has been suggested--but never tested--that extending sleep will facilitate weight loss. Therefore, the goal is of this project is to lay the groundwork for a future clinical trial testing the ..
  46. The Effect of Gastric Bypass Surgery on Renal Function and Metabolism
    Benjamin K Canales; Fiscal Year: 2013
    ..in particular Roux-en-Y-gastric bypass (RYGB), are increasing as an interventional strategy to facilitate weight loss in this population...
  47. Can diet- &exercise-induced weight loss improve asthma control in obese adults?
    Jun Ma; Fiscal Year: 2013
    ..Although current evidence of the effects of weight loss on asthma outcomes is encouraging, it is far from being conclusive...
  48. A simple dietary message to improve dietary quality for metabolic syndrome
    Yunsheng Ma; Fiscal Year: 2012
    ..b>Weight loss is paramount in recommendations for metabolic syndrome...
  49. Impact of Cardiovascular and Weight Loss diets on Uric Acid and Gout Risk
    Hyon K Choi; Fiscal Year: 2013
    ..With our extensive gout research experience combined with resourceful data access, we are in a unique and unparalleled position to address these key issues facing the field in the US and beyond. ..
  50. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
    ..asthma and obesity, and demonstrated increased obstruction with weight gain and decreased obstruction with weight loss. However, the mechanisms that underlie this linkage are not known...
  51. Randomized Trial of a Postpartum Diabetes Prevention Program for Hispanic Women
    Lisa Chasan-Taber; Fiscal Year: 2013
    ..Specific aims are to evaluate the impact of the intervention on 1) postpartum weight loss, 2) biomarkers associated with insulin resistance (i.e...
  52. Exploring the Impact of Negative Energy Balance in Men with Prostate Cancer
    Wendy Demark-Wahnefried; Fiscal Year: 2013
    ..that negative energy balance from both caloric restriction and increased physical activity that results in weight loss may suppress several hormonal and inflammatory factors that drive tumor growth, e.g...
  53. TAM receptor tyrosine kinases in inflammatory bowel disease
    Carla Rothlin; Fiscal Year: 2013
    ..inflammatory disorders of the gastrointestinal tract characterized by diarrhea, bleeding, abdominal pain, and weight loss. It can progress to serious complications due to severe inflammation, like intestinal perforation, fistula ..
  54. A Mindfulness-Based Approach to the Treatment of Obesity and Diabetes
    Carla K Miller; Fiscal Year: 2010
    ..S. The prevention of weight gain and promotion of weight loss using novel approaches among people with diabetes is needed to reduce the morbidity and mortality associated ..
  55. Identification of key tumor cell-released factors that induce cachexia
    Yi Ping Li; Fiscal Year: 2013
    ..The prominent clinical feature of cachexia is weight loss, along with anorexia, inflammation, insulin resistance, and increased muscle protein breakdown...
  56. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2013
    ..An association between clinical symptoms (diarrhea, weight loss, skin lesions, etc...
  57. Genome-wide Association Study: Fetal Hemoglobin Phenotypes in Sickle Cell Disease
    Betty Pace; Fiscal Year: 2009
    ..Further, the recent publication of the lay press book, The South Beach Diet Supercharged: Faster Weight Loss and Better Health for Life has brought INT into the public limelight despite the paucity of clinical studies ..
  58. Rev-ERBa Regulates Mitochondrial Biogenesis, Adiposity, and Insulin Action
    Thomas H Reynolds; Fiscal Year: 2010
    ..associated with an increase in Akt/PKB expression, a finding that is distinct from caloric restriction induced weight loss. Our hypothesis is that the increase in Akt/PKB levels in mice treated with MnTBA porphyrin is due to the ..
  59. Alterations in Adipocyte Lipid Metabolism by Trans-10, Cis-12 CLA Supplementation
    LAURA JANE DEN HARTIGH; Fiscal Year: 2013
    ..by applicant): Conjugated linoleic acid (CLA) is a natural dietary trans fatty acid reported to promote weight loss by unknown mechanisms...
  60. Improving Outcomes for Women with GDM and Their Infants
    Alison M Stuebe; Fiscal Year: 2013
    ..control and infant health, and that continue after birth to promote improved nutrition, exercise patterns, and weight loss. Using a two-group, repeated measures experimental design, this proposed study will test a 14-week intensive ..
  61. Restorative Yoga for Therapy of the Metabolic Syndrome (RHYTHMS) study
    Alka M Kanaya; Fiscal Year: 2012
    ..these risks, but many individuals with increased metabolic risk find it difficult to achieve and maintain weight loss and increased physical activity...
    Theodore W Kurtz; Fiscal Year: 2012
    ..It is well established that weight loss and exercise can be effective in ameliorating hypertension, diabetes, and the metabolic syndrome, however, such ..
  63. Melanocortin-4 Receptor-dependent regulation of energy balance after gastric bypa
    Vincent Aguirre; Fiscal Year: 2013
    ..research and clinical training uniquely situate me to investigate how Roux- en-Y gastric bypass (RYGB) causes weight loss and improves diabetes...
  64. Creation of Eating/Activity Environments by New Mothers
    Deborah Young Hyman; Fiscal Year: 2010
    ..Interventions to facilitate weight loss have, on balance, been unsuccessful...
  65. Animal Models Workshop: The Physiology of Weight Loss Surgery
    LEE MICHAEL KAPLAN; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The use of animal models of weight loss surgery to explore the physiological regulation of energy balance and metabolic function has increased dramatically during the past five years...
  66. Obesity, Biomechanics, and Inflammation in Osteoarthritis
    Farshid Guilak; Fiscal Year: 2013
    ..In Aim 2, we will examine the effects of obesity (via high-fat diet or leptin deficiency) and weight loss on the progression of OA in a destabilized medial meniscus model of mouse OA...
  67. Eicosapentaenoic acid and protein modulation to induce anabolism in COPD
    MARIELLE PKJ ENGELEN; Fiscal Year: 2012
    ..EPA+DHA supplementation has been shown to effectively inhibit weight loss, however, weight and muscle mass gain was not achieved both in cancer and COPD...
    Eleanor Young; Fiscal Year: 1991
    ..With the past 20 ys there has been a plethora of popular diets that promote rapid weight loss. Semistarvation (SS) or very low calorie, high protein were designed to overcome the adverse effects of ..
  69. PRIDE: Program to Reduce Incontinence by Diet & Exercise
    Deborah Grady; Fiscal Year: 2007
    ..to a 6-month intensive behavioral weight control programor to usual care to determine the short-term effect of weight loss on frequency of incontinence and quality of life, to identify women most likely to benefit from weight loss and ..
    Linda Craighead; Fiscal Year: 2001
    ..Between 5-8% of overweight individuals in Community samples, and 30% of those in hospital-affiliated weight loss programs, meet Criteria for binge eating disorder (BED)...
  71. Molecular Mechanisms Mediating Resistance to Leptin Signaling During Fat Gain
    Virend Somers; Fiscal Year: 2009
    ..The failure of elevated leptin to elicit weight loss in common forms of human obesity suggests the attenuation of leptin action (leptin resistance)...
  72. A Pilot of Customized Continuous Care Management of Obesity in Pre-Diabetics
    Jun Ma; Fiscal Year: 2010
    ..Obese or overweight individuals with pre-diabetes are at high risk of progression to diabetes. Weight loss is the dominant predictor of reduced diabetes incidence in these individuals...
  73. Frontiers in Statistical Genetics for NIAMS Researchers
    Hemant Tiwari; Fiscal Year: 2005
    ..This might suggest that, among obese individuals, weight loss will increase longevity, but this has yet to be demonstrated...
  74. Childhood Obesity Treatment: A Maintenance Approach
    DENISE ELLA WILFLEY; Fiscal Year: 2010
    ..activity habits underscore the potential importance of carefully assessing neighborhood-level variables in weight loss clinical trials...
  75. Design and Evaluation of the Remote Intervention for Diet and Exercise (RIDE)
    Corby K Martin; Fiscal Year: 2010
    ..provided by applicant): A large proportion of the adult population in the United States qualifies for weight loss treatment based on the NIH treatment recommendations, but traditional clinic-based weight loss treatments have ..
    VESTA BRUE; Fiscal Year: 2010
    ..S. Post-surgical patients can see dramatic weight loss due to mal-absorption of food through bypassing sections of the small intestine limits food intake...
    DIETER KRAMSCH; Fiscal Year: 1992
    ..However, the majority of these patients regain weight, usually in repeated cycles of weight loss/regain (yo-yo dieting)...
  78. Weight Loss and Exercise in Frail Obese Elderly Subjects
    DENNIS VILLAREAL; Fiscal Year: 2009
    ..relative health risks with increasing body mass index in the elderly and the potential harmful effects of weight loss on bone health and muscle mass...
  79. Reducing Obesity in Underserved Postpartum African American Women
    Caroline M Apovian; Fiscal Year: 2010
    ..9% of white women. In addition to the obesity disparity, although many African American women attempt weight loss in the US, they are not as successful at weight loss as Caucasian women...
  80. Innovative Technology to Improve Patient Adherence to Weight Loss Recommendations
    Rena R Wing; Fiscal Year: 2010
    ..Although many Americans indicate that they are trying to lose weight, adherence to weight loss regimens is often poor...
  81. Muscle quality, exercise and weight loss in older women: A quantitative MRI stud
    JOHN GEORGIADIS; Fiscal Year: 2009
    ..b>Weight loss and exercise regimens effects on IMTG may alter myofiber orientation and density, and subsequently alter the ..
  82. Analysis of five year follow-up data from the Weight Loss Maintenance Trial
    Victor J Stevens; Fiscal Year: 2010
    ..Fortunately, even modest weight loss improves these risk factors, and well-designed, contemporary behavioral interventions typically yield a ..
  83. The Role of Bile Acids in Surgically-induced Weight Loss
    NADIA NAZIR AHMAD; Fiscal Year: 2010
    ..As a remarkably effective weight loss surgery that works via neurohumoral pathways to dramatically alter hunger, satiety, and energy balance, RYGB ..