weight gain

Summary

Summary: Increase in BODY WEIGHT over existing weight.

Top Publications

  1. pmc Intake of sugar-sweetened beverages and weight gain: a systematic review
    Vasanti S Malik
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 84:274-88. 2006
  2. pmc Changes in diet and lifestyle and long-term weight gain in women and men
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:2392-404. 2011
  3. ncbi Ghrelin induces adiposity in rodents
    M Tschop
    Endocrine Research and BioResearch Technologies and Proteins, Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Nature 407:908-13. 2000
  4. pmc Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors: the Jerusalem Perinatal Family Follow-up Study
    Hagit Hochner
    Hebrew University Hadassah, Braun School of Public Health, Jerusalem, Israel
    Circulation 125:1381-9. 2012
  5. ncbi Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain
    Eva Qing Ye
    Program on Genomics and Nutrition, School of Public Health, University of California, Los Angeles, CA, USA
    J Nutr 142:1304-13. 2012
  6. ncbi Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women
    Matthias B Schulze
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    JAMA 292:927-34. 2004
  7. ncbi Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    Jeffrey A Lieberman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    N Engl J Med 353:1209-23. 2005
  8. pmc Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood
    Abigail Fraser
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Circulation 121:2557-64. 2010
  9. ncbi Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Lancet 373:31-41. 2009
  10. pmc Short sleep duration and weight gain: a systematic review
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Obesity (Silver Spring) 16:643-53. 2008

Detail Information

Publications351 found, 100 shown here

  1. pmc Intake of sugar-sweetened beverages and weight gain: a systematic review
    Vasanti S Malik
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 84:274-88. 2006
    ..Whether an association exists between SSB intake and weight gain is unclear...
  2. pmc Changes in diet and lifestyle and long-term weight gain in women and men
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:2392-404. 2011
    Specific dietary and other lifestyle behaviors may affect the success of the straightforward-sounding strategy "eat less and exercise more" for preventing long-term weight gain.
  3. ncbi Ghrelin induces adiposity in rodents
    M Tschop
    Endocrine Research and BioResearch Technologies and Proteins, Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Nature 407:908-13. 2000
    ..Here we show that peripheral daily administration of ghrelin caused weight gain by reducing fat utilization in mice and rats...
  4. pmc Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors: the Jerusalem Perinatal Family Follow-up Study
    Hagit Hochner
    Hebrew University Hadassah, Braun School of Public Health, Jerusalem, Israel
    Circulation 125:1381-9. 2012
    Accumulating evidence demonstrates that both maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) are associated with adult offspring adiposity...
  5. ncbi Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain
    Eva Qing Ye
    Program on Genomics and Nutrition, School of Public Health, University of California, Los Angeles, CA, USA
    J Nutr 142:1304-13. 2012
    ..whole-grain and fiber intake in relation to risk of type 2 diabetes (T2D), cardiovascular disease (CVD), weight gain, and metabolic risk factors...
  6. ncbi Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women
    Matthias B Schulze
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    JAMA 292:927-34. 2004
    ..beverages like soft drinks and fruit punches contain large amounts of readily absorbable sugars and may contribute to weight gain and an increased risk of type 2 diabetes, but these relationships have been minimally addressed in adults.
  7. ncbi Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    Jeffrey A Lieberman
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    N Engl J Med 353:1209-23. 2005
    ..We compared a first-generation antipsychotic, perphenazine, with several newer drugs in a double-blind study...
  8. pmc Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood
    Abigail Fraser
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Circulation 121:2557-64. 2010
    We sought to examine the association of gestational weight gain (GWG) and prepregnancy weight with offspring adiposity and cardiovascular risk factors.
  9. ncbi Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
    Stefan Leucht
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Munich, Germany
    Lancet 373:31-41. 2009
    ....
  10. pmc Short sleep duration and weight gain: a systematic review
    Sanjay R Patel
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH, USA
    Obesity (Silver Spring) 16:643-53. 2008
    ..This work reviews the literature regarding short sleep duration as an independent risk factor for obesity and weight gain.
  11. ncbi Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models
    E F Murphy
    Alimentary Pharmabiotic Centre, University College Cork, Ireland
    Gut 59:1635-42. 2010
    ..Therefore, we explored the effect of a high-fat (HF) diet and genetically determined obesity (ob/ob) for changes in microbiota and energy harvesting capacity over time...
  12. ncbi Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge, UK
    Acta Paediatr 95:904-8. 2006
    In a systematic review, we identified 21 separate studies with data on the association between rapid infancy weight gain, up to age 2 y, and subsequent obesity risk. Uniformly all studies reported significant positive associations...
  13. ncbi Combined associations of prepregnancy body mass index and gestational weight gain with the outcome of pregnancy
    Ellen A Nohr
    Department of Epidemiology, Institute of Public Health, University of Aarhus, Aarhus, Denmark
    Am J Clin Nutr 87:1750-9. 2008
    Although both maternal prepregnancy body mass index (BMI) and gestational weight gain (GWG) may affect birth weight, their separate and joint associations with complications of pregnancy and delivery and with postpartum weight retention ..
  14. ncbi Identifying risk for obesity in early childhood
    Philip R Nader
    Division of Community Pediatrics, University of California, San Diego, California, USA
    Pediatrics 118:e594-601. 2006
    ..Our aim with this study was to assist clinicians by estimating the predictive value of earlier levels of BMI status on later risk of overweight and obesity during the middle childhood and early adolescent years...
  15. pmc Gestational weight gain and child adiposity at age 3 years
    Emily Oken
    Obesity Prevention Program, Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Am J Obstet Gynecol 196:322.e1-8. 2007
    The purpose of this study was to examine the associations of gestational weight gain with child adiposity.
  16. pmc Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts
    Shane A Norris
    Medical Research Council Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Diabetes Care 35:72-9. 2012
    We examined associations of birth weight and weight gain in infancy and early childhood with type 2 diabetes (DM) risk in five cohorts from low- and middle-income countries.
  17. ncbi Fructose, weight gain, and the insulin resistance syndrome
    Sharon S Elliott
    Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 76:911-22. 2002
    ..in individuals who consume diets that are high in dietary fructose could therefore increase the likelihood of weight gain and its associated metabolic sequelae...
  18. pmc FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies
    Jens K Hertel
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Diabetes 60:1637-44. 2011
    ..FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult life span...
  19. ncbi Maternal obesity: pregnancy complications, gestational weight gain and nutrition
    I Guelinckx
    Department of Nutrition and Health Preventive Medicine, Catholic University Leuven, University Hospital Gasthuisberg, Leuven, Belgium
    Obes Rev 9:140-50. 2008
    ..Furthermore, gestational weight gain (GWG) of obese pregnant women generally exceeds the Institute of Medicine recommended ranges...
  20. ncbi Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    Steven E Kahn
    Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    N Engl J Med 355:2427-43. 2006
    ..The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known...
  21. ncbi How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement
    W H M Saris
    Nutrition and Toxicology Research Institute, Maastricht NUTRIM, University of Maastricht, Department of Human Biology, Maastricht, The Netherlands
    Obes Rev 4:101-14. 2003
    ..However for preventing weight gain or regain this guideline is likely to be insufficient for many individuals in the current environment...
  22. ncbi Family- and school-based correlates of energy balance-related behaviours in 10-12-year-old children: a systematic review within the ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) project
    Maite Verloigne
    Department of Movement and Sport Sciences, Ghent University, Watersportlaan 2, B 9000 Ghent, Belgium
    Public Health Nutr 15:1380-95. 2012
    ..energy balance-related behaviours (physical activity, sedentary behaviour, breakfast consumption, soft drink consumption) among 10-12-year-olds, using the EnRG framework (Environmental Research framework for weight Gain prevention).
  23. ncbi Who succeeds in maintaining weight loss? A conceptual review of factors associated with weight loss maintenance and weight regain
    K Elfhag
    Obesity Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Obes Rev 6:67-85. 2005
    ..Factors that may pose a risk for weight regain include a history of weight cycling, disinhibited eating, binge eating, more hunger, eating in response to negative emotions and stress, and more passive reactions to problems...
  24. ncbi The developmental origins of adult disease
    D J P Barker
    University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
    J Am Coll Nutr 23:588S-595S. 2004
    ..Recent observations have shown that impaired growth in infancy and rapid childhood weight gain exacerbate the effects of impaired prenatal growth...
  25. pmc Fetuses of obese mothers develop insulin resistance in utero
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University at Metro Health Medical Center, Cleveland, Ohio, USA
    Diabetes Care 32:1076-80. 2009
    ..The purpose of this study was to determine whether fetuses of obese women have increased obesity, insulin resistance, and markers of inflammation, supporting the concept of fetal programming...
  26. ncbi Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: a meta-analytic comparison of randomized controlled trials
    Jacqueline Caemmerer
    Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Schizophr Res 140:159-68. 2012
    To evaluate the efficacy of non-pharmacological interventions for antipsychotic-associated weight gain.
  27. pmc Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
    E Stice
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    Science 322:449-52. 2008
    ....
  28. ncbi Prepregnancy body mass index and gestational weight gain with the outcome of pregnancy: a 13-year study of 292,568 cases in China
    Yuanyuan Liu
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No 38 Xueyuan Road, Haidian District, Beijing 100191, People s Republic of China
    Arch Gynecol Obstet 286:905-11. 2012
    We aimed to investigate the combined associations of prepregnancy body mass index (BMI) and gestational weight gain (GWG) with pregnancy outcomes in Chinese women.
  29. ncbi Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner
    Jessica L Bolton
    Duke University, Department of Psychology and Neuroscience, 210 Research Dr, Box 91050, 3019 GSRB II, Durham, NC 27708, USA
    FASEB J 26:4743-54. 2012
    ..We tested the hypothesis that prenatal air pollution exposure would predispose the offspring to weight gain in adulthood. Pregnant mice were exposed to filtered air (FA) or diesel exhaust (DE) on embryonic days (E) 9-17...
  30. ncbi Excessive gestational weight gain predicts large for gestational age neonates independent of maternal body mass index
    Z M Ferraro
    Faculty of Health Sciences, School of Human Kinetics, University of Ottawa, Ontario, Canada
    J Matern Fetal Neonatal Med 25:538-42. 2012
    To determine the effects of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on large-for-gestational-age (LGA) birth weight (≥90th % ile).
  31. pmc Circadian timing of food intake contributes to weight gain
    Deanna M Arble
    Center for Sleep and Circadian Biology, Northwestern University, Evanston, Illinois, USA
    Obesity (Silver Spring) 17:2100-2. 2009
    ..behavioral levels raise the possibility that the timing of food intake itself may play a significant role in weight gain. The present study focused on the role of the circadian phase of food consumption in weight gain...
  32. pmc The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interven
    Jonathan Q Purnell
    Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Circulation 127:180-7. 2013
    ..therapy of type 1 diabetes mellitus reduces diabetes mellitus complications but can be associated with excess weight gain, central obesity, and dyslipidemia...
  33. ncbi Early determinants of overweight at 4.5 years in a population-based longitudinal study
    L Dubois
    Canada Research Chair in Nutrition and Population Health, Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    Int J Obes (Lond) 30:610-7. 2006
    ..5 years, to determine which factors exert the most influence in early life...
  34. ncbi Interventions during pregnancy to reduce excessive gestational weight gain: a systematic review assessing current clinical evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system
    A K Ronnberg
    Department of Obstetrics and Gynaecology, Orebro University Hospital, Orebro, Sweden
    BJOG 117:1327-34. 2010
    Excessive weight gain during pregnancy is common in developed countries and increases the risk of complications during pregnancy, delivery and the postpartum period, which can affect both maternal and fetal outcome...
  35. ncbi The role of histaminergic H1 and H3 receptors in food intake: a mechanism for atypical antipsychotic-induced weight gain?
    Chao Deng
    Centre for Translational Neuroscience, School of Health Sciences, University of Wollongong, Wollongong, 2522, NSW, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 34:1-4. 2010
    ..However a major downfall to their use is metabolic side-effects particularly weight gain/obesity, which occurs by unknown mechanisms...
  36. pmc EuropeaN Energy balance Research to prevent excessive weight Gain among Youth (ENERGY) project: Design and methodology of the ENERGY cross-sectional survey
    Maartje M van Stralen
    Department of Public and Occupational Health, VU University Medical Center, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands
    BMC Public Health 11:65. 2011
    Obesity treatment is by large ineffective long term, and more emphasis on the prevention of excessive weight gain in childhood and adolescence is warranted...
  37. pmc Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis
    Christine Rummel-Kluge
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie der Technischen Universitat Munchen, Klinikum rechts der Isar, Möhlstr 26, 81675 Munchen, Germany
    Schizophr Res 123:225-33. 2010
    ..We conducted a meta-analysis of studies comparing the metabolic side effects of the following SGAs head-to-head: amisulpride, aripiprazole, clozapine, olanzapine, quetiapine, risperidone, sertindole, ziprasidone, zotepine...
  38. ncbi Time spent being sedentary and weight gain in healthy adults: reverse or bidirectional causality?
    Ulf Ekelund
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    Am J Clin Nutr 88:612-7. 2008
    ..Whether obesity is a cause or a consequence of a sedentary lifestyle has not yet been fully elucidated, which leaves uncertainty about the direction of causality...
  39. ncbi Changing diet and physical activity to reduce gestational weight gain: a meta-analysis
    B Gardner
    Health Behaviour Research Centre, Department of Epidemiology and Public Health, University College London, London, UK
    Obes Rev 12:e602-20. 2011
    Excessive pregnancy weight gain is associated with adverse maternal and child health outcomes...
  40. ncbi Gestational weight gain and long-term postpartum weight retention: a meta-analysis
    Ina Nehring
    Division of Epidemiology, Institute of Social Pediatrics and Adolescent Medicine, Ludwig Maximilians Universitat Munchen, Freising, Germany
    Am J Clin Nutr 94:1225-31. 2011
    Gestational weight gain (GWG) is known to be a potential risk factor for short-term postpartum weight retention (PPWR) and thus for overweight in women. Does GWG also determine the long-term risk of overweight in women?
  41. ncbi Effect of noninsulin antidiabetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
    Olivia J Phung
    University of Connecticut School of Pharmacy, Storrs, and Drug Information Center, Hartford Hospital, Hartford, Connecticut 06102 5037, USA
    JAMA 303:1410-8. 2010
    ..Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin monotherapy fails is unclear...
  42. ncbi Can gestational weight gain be modified by increasing physical activity and diet counseling? A meta-analysis of interventional trials
    Ina Streuling
    Division of Epidemiology, Institute of Social Pediatrics and Adolescent Medicine, Ludwig Maximilians University of Munich, Munich, Germany
    Am J Clin Nutr 92:678-87. 2010
    Excessive gestational weight gain (GWG) increases the risk of a number of adverse pregnancy outcomes and was recently identified as a potential risk factor for childhood obesity...
  43. ncbi Obesity and the environment: where do we go from here?
    James O Hill
    Center for Human Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 299:853-5. 2003
    ..There is an urgent need to push back against the environmental forces that are producing gradual weight gain in the population...
  44. ncbi Fast food consumption and breakfast skipping: predictors of weight gain from adolescence to adulthood in a nationally representative sample
    Heather M Niemeier
    Weight Control and Diabetes Research Center, The Miriam Hospital Brown Medical School, Providence, Rhode Island 02903, USA
    J Adolesc Health 39:842-9. 2006
    To investigate whether fast food consumption and breakfast skipping are associated with weight gain during the transition from adolescence to adulthood.
  45. ncbi Early origins of cardiovascular disease: is there a unifying hypothesis?
    Atul Singhal
    MRC Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Lancet 363:1642-5. 2004
  46. ncbi Randomized controlled trial to prevent excessive weight gain in pregnant women
    B A Polley
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Int J Obes Relat Metab Disord 26:1494-502. 2002
    ..8-11.4 kg). A significant number of normal-weight women and an even greater proportion of overweight women exceed these guidelines, which increases postpartum weight retention and may contribute to the development of obesity...
  47. ncbi Preventing excessive weight gain during pregnancy through dietary and lifestyle counseling: a randomized controlled trial
    Shelly M Asbee
    Carolinas Medical Center, Charlotte, North Carolina, USA
    Obstet Gynecol 113:305-12. 2009
    To estimate whether an organized, consistent program of dietary and lifestyle counseling prevents excessive weight gain in pregnancy.
  48. ncbi H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs
    Wesley K Kroeze
    Department of Biochemistry, RM W463, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4935, USA
    Neuropsychopharmacology 28:519-26. 2003
    ..b>Weight gain is a common and potentially serious complication of some antipsychotic drug therapy, and may be accompanied by ..
  49. ncbi Gestational weight gain: influences on the long-term health of the child
    Lucilla Poston
    Division of Women s Health, King s College London, St Thomas Hospital, London, UK
    Curr Opin Clin Nutr Metab Care 15:252-7. 2012
    To address the recent evidence which suggests that inappropriate gestational weight gain (GWG) may have consequences that extend to the longer term health of the child.
  50. ncbi The consequences of obesity and excess weight gain in pregnancy
    Jane E Norman
    Tommy s Centre for Maternal and Fetal Health, MRC Centre for Reproductive Health, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TY, UK
    Proc Nutr Soc 70:450-6. 2011
    ..The risk of the majority of these complications is amplified by excess weight gain in pregnancy and increases in proportion to the degree of obesity, for example, women with extreme obesity have ..
  51. ncbi Maternal weight gain during the first half of pregnancy and offspring obesity at 16 years: a prospective cohort study
    J Laitinen
    Finnish Institute of Occupational Health, Oulu, Finland
    BJOG 119:716-23. 2012
    To assess the association between maternal gestational weight gain (GWG) during the first 20 weeks of gestation and overweight/obesity and abdominal obesity of offspring at the age of 16 years.
  52. ncbi Diet, nutrition and the prevention of excess weight gain and obesity
    B A Swinburn
    Physical Activity and Nutrition Research Unit, School of Health Sciences, Deakin University, Melbourne, Australia
    Public Health Nutr 7:123-46. 2004
    ..To review the evidence on the diet and nutrition causes of obesity and to recommend strategies to reduce obesity prevalence...
  53. pmc The association between pregnancy weight gain and birthweight: a within-family comparison
    David S Ludwig
    Department of Medicine, Children s Hospital, Boston, MA 02115, USA
    Lancet 376:984-90. 2010
    Excessive weight gain during pregnancy seems to increase birthweight and the offspring's risk of obesity later in life. However, this association might be confounded by genetic and other shared effects...
  54. pmc Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
    Anutosh Chakraborty
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 143:897-910. 2010
    ..IP6K1 knockout mice manifest insulin sensitivity and are resistant to obesity elicited by high-fat diet or aging. Inhibition of IP6K1 may afford a therapeutic approach to obesity and diabetes...
  55. ncbi Achieving a clinically relevant composite outcome of an HbA1c of <7% without weight gain or hypoglycaemia in type 2 diabetes: a meta-analysis of the liraglutide clinical trial programme
    B Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Diabetes Obes Metab 14:77-82. 2012
    ..we performed a meta-analysis of data from these trials evaluating the proportion of patients achieving a clinically relevant composite measure of diabetes control consisting of an HbA1c <7% without weight gain or hypoglycaemia.
  56. ncbi Understanding and addressing the epidemic of obesity: an energy balance perspective
    James O Hill
    Center for Human Nutrition, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Endocr Rev 27:750-61. 2006
    ..the study of how behavioral and environmental factors have interacted to produce positive energy balance and weight gain. Reversing the epidemic of obesity will require modifying some combination of these factors to help the ..
  57. pmc Individual differences in nucleus accumbens activity to food and sexual images predict weight gain and sexual behavior
    Kathryn E Demos
    Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Neurosci 32:5549-52. 2012
    ..in human reward-related brain activity in the nucleus accumbens to food and sexual images predict subsequent weight gain and sexual activity 6 months later...
  58. ncbi Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation
    Kazuko Masuo
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
    Hypertension 42:474-80. 2003
    ..the relations between serum uric acid, plasma norepinephrine, and insulin or leptin levels in subjects with weight gain-induced blood pressure elevation, we conducted the present longitudinal study...
  59. pmc Associations of linear growth and relative weight gain during early life with adult health and human capital in countries of low and middle income: findings from five birth cohort studies
    Linda S Adair
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516 2524, USA
    Lancet 382:525-34. 2013
    Fast weight gain and linear growth in children in low-income and middle-income countries are associated with enhanced survival and improved cognitive development, but might increase risk of obesity and related adult cardiometabolic ..
  60. pmc Weight status in the first 6 months of life and obesity at 3 years of age
    Elsie M Taveras
    Department of Ambulatory Care and Prevention, Harvard Medical School, Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
    Pediatrics 123:1177-83. 2009
    ..The goal was to examine the associations of weight-for-length at birth and at 6 months with obesity at 3 years of age...
  61. pmc Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
    Cathy E Elks
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Med 7:e1000284. 2010
    ..Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity...
  62. ncbi Preventing excessive gestational weight gain: a systematic review of interventions
    H Skouteris
    Deakin University, Melbourne, Vic, Australia
    Obes Rev 11:757-68. 2010
    ..excessive weight during pregnancy have an increased risk of post-partum obesity, and retention of gestational weight gain (GWG) post birth is a strong predictor of maternal overweight/obesity a decade or more after the birth...
  63. pmc Associations of gestational weight gain with maternal body mass index, waist circumference, and blood pressure measured 16 y after pregnancy: the Avon Longitudinal Study of Parents and Children (ALSPAC)
    Abigail Fraser
    MRC Centre for Causal Analyses in Translational Epidemiology and the School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Am J Clin Nutr 93:1285-92. 2011
    Little is known about associations of gestational weight gain (GWG) with long-term maternal health.
  64. ncbi Infant growth and later body composition: evidence from the 4-component model
    Sirinuch Chomtho
    The Medical Research Council, Childhood Nutrition Research Centre, Institute of Child Health, University College London, London, United Kingdom
    Am J Clin Nutr 87:1776-84. 2008
    Rapid weight gain in infancy is associated with higher body mass index in later life, but its relation with individual body-composition components remains unclear.
  65. ncbi Early growth patterns and long-term obesity risk
    Nicolas Stettler
    The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Clin Nutr Metab Care 13:294-9. 2010
    ..These data are important because the potential programming of obesity in early life provides hope for new prevention strategies targeting early growth for long-term benefits...
  66. ncbi Preventing excessive weight gain during pregnancy - a controlled trial in primary health care
    T I Kinnunen
    UKK Institute for Health Promotion Research, Tampere, Finland
    Eur J Clin Nutr 61:884-91. 2007
    To investigate whether individual counselling on diet and physical activity during pregnancy can have positive effects on diet and leisure time physical activity (LTPA) and prevent excessive gestational weight gain.
  67. pmc Randomized trial of a behavioral intervention to prevent excessive gestational weight gain: the Fit for Delivery Study
    Suzanne Phelan
    Departments of Kinesiology, California Polytechnic State University, San Luis Obispo, 93407 0386, USA
    Am J Clin Nutr 93:772-9. 2011
    Excessive weight gain during pregnancy is a major risk factor for postpartum weight retention and future weight gain and obesity in women, but few adequately powered randomized controlled trials have examined the efficacy of a behavioral ..
  68. ncbi Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood
    Ralph W J Leunissen
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    JAMA 301:2234-42. 2009
    ..Growth during infancy appears to be an important determinant of cardiovascular disease and type 2 diabetes later in life...
  69. pmc Systematic review of clinical trials on dietary interventions to prevent excessive weight gain during pregnancy among normal weight, overweight and obese women
    Ida Tanentsapf
    Faculty of Health Sciences, Copenhagen University, Panum Instituttet, Copenhagen, Denmark
    BMC Pregnancy Childbirth 11:81. 2011
    Excessive weight gain during pregnancy and subsequent postpartum weight retention may contribute to the epidemic of obesity among women of childbearing age...
  70. ncbi A systematic review of studies on socioeconomic inequalities in dietary intakes associated with weight gain and overweight/obesity conducted among European adults
    K Giskes
    Department of Public Health, Erasmus Medical Center, Rotterdam, The
    Obes Rev 11:413-29. 2010
    This Review examined socioeconomic inequalities in intakes of dietary factors associated with weight gain, overweight/obesity among adults in Europe...
  71. ncbi Effect of antihyperglycemic agents added to metformin and a sulfonylurea on glycemic control and weight gain in type 2 diabetes: a network meta-analysis
    Jorge L Gross
    Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil
    Ann Intern Med 154:672-9. 2011
    ..Few studies have examined the effect of adding a third antihyperglycemic drug when blood glucose control is not achieved by using metformin and a sulfonylurea...
  72. ncbi Antidepressants and body weight: a comprehensive review and meta-analysis
    Alessandro Serretti
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy
    J Clin Psychiatry 71:1259-72. 2010
    Psychotropic drugs often induce weight gain, leading to discomfort and discontinuation of treatment and, more importantly, increasing the risk of obesity-related illnesses such as diabetes mellitus, hypertension, and coronary heart ..
  73. ncbi The relationship between gut microbiota and weight gain in humans
    Emmanouil Angelakis
    Unite des Rickettsies, URMITE CNRS UMR 6236 IRD 198, IFR 48, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Future Microbiol 7:91-109. 2012
    ..Recently, microbial changes in the human gut were proposed to be one of the possible causes of obesity. This review summarizes the latest research on the association between microbial ecology and host weight...
  74. ncbi Antipsychotic-induced weight gain: a comprehensive research synthesis
    D B Allison
    Obesity Research Center, St Luke s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, NY 10025, UDA
    Am J Psychiatry 156:1686-96. 1999
    ..The purpose of this study was to estimate and compare the effects of antipsychotics-both the newer ones and the conventional ones-on body weight...
  75. pmc Excess gains in weight and waist circumference associated with childbearing: The Coronary Artery Risk Development in Young Adults Study (CARDIA)
    E P Gunderson
    Kaiser Permanente Foundation Hospitals, Division of Research, 2000 Broadway, Oakland, CA 94612, USA
    Int J Obes Relat Metab Disord 28:525-35. 2004
    ..To examine the association of childbearing with weight and waist circumference (WC) changes, we compared women with and without pregnancies or births during follow-up...
  76. ncbi Relationship between stress, eating behavior, and obesity
    Susan J Torres
    Centre for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
    Nutrition 23:887-94. 2007
    ..Evidence from longitudinal studies suggests that chronic life stress may be causally linked to weight gain, with a greater effect seen in men...
  77. ncbi Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula
    Nicolas Stettler
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, 36th St and Civic Center Blvd, Philadelphia, PA 19104 4399, USA
    Circulation 111:1897-903. 2005
    ..Rapid infancy weight gain is associated with childhood obesity, whereas low infancy weight is associated with coronary heart disease...
  78. ncbi Smoking cessation and weight gain
    C Filozof
    Unidad de Tabaquismo, Area de Prevención y Rehabilitación Cardiaca, Instituto Cardiovascular, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain
    Obes Rev 5:95-103. 2004
    ..Smoking cessation is associated with substantial health benefits. Weight gain is cited as a primary reason for not trying to quit smoking...
  79. ncbi Effect of lifestyle intervention on dietary habits, physical activity, and gestational weight gain in obese pregnant women: a randomized controlled trial
    Isabelle Guelinckx
    Department of Nutrition Public Health Medicine, LFoRCe, Catholic University Leuven, Leuven, Belgium
    Am J Clin Nutr 91:373-80. 2010
    Maternal obesity and excessive gestational weight gain (GWG) are major short- and long-term risk factors for maternal and fetal complications.
  80. pmc Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents
    Christoph U Correll
    Zucker Hillside Hospital, Psychiatry Research, North Shore Long Island Jewish Health System, 75 59 263rd St, Glen Oaks, NY 11004, USA
    JAMA 302:1765-73. 2009
    ..Cardiometabolic effects of second-generation antipsychotic medications are concerning but have not been sufficiently studied in pediatric and adolescent patients naive to antipsychotic medication...
  81. ncbi Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity
    Carolyn Wu
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Arch Ophthalmol 128:443-7. 2010
    To validate longitudinal postnatal weight gain as a method for predicting severe retinopathy of prematurity (ROP) in a US cohort.
  82. ncbi Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications
    T A P Lett
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Mol Psychiatry 17:242-66. 2012
    ..However, most SGAs, and to a lesser degree FGAs, are linked to substantial weight gain. This substantial weight gain is a leading factor in patient non-compliance and poses significant risk of ..
  83. ncbi Monosodium glutamate is not associated with obesity or a greater prevalence of weight gain over 5 years: findings from the Jiangsu Nutrition Study of Chinese adults
    Zumin Shi
    Department of Nutrition and Foodborne Disease Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, 172 Jiangsu Road, Nanjing, China
    Br J Nutr 104:457-63. 2010
    ..MSG intake and obesity, and determine whether a greater MSG intake is associated with a clinically significant weight gain over 5 years...
  84. ncbi Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children
    Lourdes Ibanez
    Endocrinology Unit, Hospital Sant Joan de Deu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950 Esplugues, Barcelona, Spain
    J Clin Endocrinol Metab 91:2153-8. 2006
    Low birth weight followed by rapid postnatal weight gain is associated with long-term risks for central obesity and insulin resistance. However, the timing of these changes is unclear.
  85. ncbi Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis
    Vincenzo De Luca
    University of Toronto, Centre for Addiction and Mental Health, Neurogenetics Section, Toronto, ON, Canada
    Int J Neuropsychopharmacol 10:697-704. 2007
    ..gene (HTR2C) develop obesity and that many atypical antipsychotics with potent 5-HT2C antagonism may induce weight gain in susceptible individuals...
  86. ncbi Metabolic and cardiovascular adverse effects associated with antipsychotic drugs
    Marc De Hert
    University Psychiatric Center, Catholic University Leuven, Leuvensesteenweg 517, 3070 Kortenberg, Belgium marc de hert uc kortenberg be
    Nat Rev Endocrinol 8:114-26. 2012
    ....
  87. pmc Effect of dietary protein content on weight gain, energy expenditure, and body composition during overeating: a randomized controlled trial
    George A Bray
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    JAMA 307:47-55. 2012
    ..The role of diet composition in response to overeating and energy dissipation in humans is unclear...
  88. ncbi Weight regain after a diet-induced loss is predicted by higher baseline leptin and lower ghrelin plasma levels
    Ana B Crujeiras
    Laboratory of Molecular and Cellular Endocrinology, Instituto de Investigació n Sanitaria, Complejo Hospitalario de Santiago and Santiago de Compostela University, Santiago de Compostela, Spain
    J Clin Endocrinol Metab 95:5037-44. 2010
    ..Appetite-related hormones may play an important role in weight regain after obesity therapy...
  89. ncbi Physical activity and gestational weight gain: a meta-analysis of intervention trials
    I Streuling
    Division of Epidemiology, Institute of Social Paediatrics and Adolescent Medicine, Ludwig Maximilians University of Munich, Munich, Germany
    BJOG 118:278-84. 2011
    high gestational weight gain (GWG) has been found to be associated with a number of adverse perinatal and long-term outcomes.
  90. pmc The LiP (Lifestyle in Pregnancy) study: a randomized controlled trial of lifestyle intervention in 360 obese pregnant women
    Christina A Vinter
    Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
    Diabetes Care 34:2502-7. 2011
    To study the effects of lifestyle intervention on gestational weight gain (GWG) and obstetric outcomes.
  91. ncbi Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis
    Celine Druet
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Paediatr Perinat Epidemiol 26:19-26. 2012
    To assess the predictive ability of infant weight gain on subsequent obesity we performed a meta-analysis of individual-level data on 47,661 participants from 10 cohort studies from the UK, France, Finland, Sweden, the US and Seychelles...
  92. pmc Maintaining a high physical activity level over 20 years and weight gain
    Arlene L Hankinson
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Ste 1400, Chicago, IL 60611, USA
    JAMA 304:2603-10. 2010
    Data supporting physical activity guidelines to prevent long-term weight gain are sparse, particularly during the period when the highest risk of weight gain occurs.
  93. ncbi Early differences in fecal microbiota composition in children may predict overweight
    Marko Kalliomaki
    Functional Foods Forum and Program on Health Biosciences and the Department of Pediatrics, University of Turku, Turku, Finland
    Am J Clin Nutr 87:534-8. 2008
    ..Experimental studies suggest that gut microbiota deviations predispose toward energy storage and obesity...
  94. ncbi BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropsychopharmacology 33:2200-5. 2008
    ..We investigated whether the Val66Met polymorphism of the BDNF gene affected weight gain after long-term antipsychotic treatment in schizophrenia...
  95. ncbi Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women
    A Santacruz
    Microbial Ecophysiology and Nutrition Group, Institute of Agrochemistry and Food Technology IATA, Spanish National Research Council CSIC, Valencia, Spain
    Br J Nutr 104:83-92. 2010
    ..The objective of the present study was to establish possible relationships between gut microbiota, body weight, weight gain and biochemical parameters in pregnant women...
  96. ncbi Body mass index, provider advice, and target gestational weight gain
    Naomi E Stotland
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California 94110, USA
    Obstet Gynecol 105:633-8. 2005
    To study the relationships among prepregnancy body mass index (BMI), women's target gestational weight gain, and provider weight gain advice.
  97. ncbi Excess pregnancy weight gain and long-term obesity: one decade later
    Brenda L Rooney
    Gundersen Lutheran Medical Center, La Crosse, Wisconsin 54601, USA
    Obstet Gynecol 100:245-52. 2002
    To estimate the impact of excess pregnancy weight gain and failure to lose weight by 6 months postpartum on excess weight 8-10 years later.
  98. ncbi Food insecurity affects school children's academic performance, weight gain, and social skills
    Diana F Jyoti
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853 6301, USA
    J Nutr 135:2831-9. 2005
    ..This study provides the strongest empirical evidence to date that food insecurity is linked to specific developmental consequences for children, and that these consequences may be both nutritional and nonnutritional...
  99. ncbi Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice
    Hayato Maeda
    Faculty of Fisheries Sciences, Hokkaido University, 3 1 1 Minato, Hakodate, Hokkaido 041 8611, Japan
    J Agric Food Chem 55:7701-6. 2007
    ..We previously reported that dietary fucoxanthin attenuates the weight gain of white adipose tissue (WAT) of diabetic/obese KK- A(y) mice...
  100. ncbi Associations of gestational weight gain with offspring body mass index and blood pressure at 21 years of age: evidence from a birth cohort study
    Abdullah A Mamun
    School of Population Health, University of Queensland, Herston Rd, Herston, QLD 4006, Australia
    Circulation 119:1720-7. 2009
    Maternal weight gain in pregnancy is positively associated with offspring body mass index (BMI) and obesity risk in childhood, but whether this increased risk extends into adulthood or results in increases in other cardiovascular risk ..
  101. ncbi Obesity, weight gain, and the risk of kidney stones
    Eric N Taylor
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    JAMA 293:455-62. 2005
    ..It is unclear if obesity increases the risk of stone formation, and it is not known if weight gain influences risk.

Research Grants81

  1. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..activation are already present in the high risk adolescents, suggesting a causal role for these factors in weight gain. K99 participants (Subjects;Ss) will be 22 (11M;11F) obese (BMI centile>95th) and 44 (22M;22F) lean (BMI ..
  2. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..of years that cannabis extracts increase appetite, particularly for highly palatable foods and can result in weight gain. The eCB system consists of two endogenous cannabinoid receptors, CB1 and CB2...
  3. Neurobehavioral Correlates of Familial/genetic obesity risk in adolescents
    Susan Carnell; Fiscal Year: 2013
    ..activation are already present in the high risk adolescents, suggesting a causal role for these factors in weight gain. K99 participants (Subjects;Ss) will be 22 (11M;11F) obese (BMI centile>95th) and 44 (22M;22F) lean (BMI ..
  4. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ....
  5. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..The side-effects of the atypical antipsychotic drugs such as clozapine, include diabetes, severe weight gain and cardiac arrhythmias...
  6. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..GI pH appears to attenuate nutritional abnormalities, as the use of proton-pump inhibitors (PPIs) normalizes weight gain during the neonatal period...
  7. Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular Function
    ANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010
    ..plausibly contribute to elevated blood pressure (BP)and vascular and pressure- sensitive target organ injury, weight gain, dyslipidemia, and glucose intolerance...
  8. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..The Primary Endpoint shall be the time to regain birth weight, daily weight gain, and number of days to hospital discharge, Incidence of nosocomial infections [late-onset bacteremia, pneumonia,..
  9. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Menopause is associated with about a 10-15 pound weight gain and a redistribution of fat to the abdomen...
  10. Neural Functioning of Feeding Centers in Obese Youth
    ROBERT STANLEY SHERWIN; Fiscal Year: 2013
    ..highly palatable foods (glucose) in obese adolescents may translate into the development of more effective weight gain and diabetes prevention program in youth...
  11. Role of GDNF in the regulation of hepatic steatosis
    SHANTHI K SRINIVASAN; Fiscal Year: 2013
    ..Recently we discovered that (i) GDNF transgenic mice when fed a high fat diet resist weight gain and development of hepatic steatosis, despite similar food intake and physical activity...
  12. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..insulin sensitivity in fat cells, increases insulin production by the pancreas, and reduces the risk of weight gain and development of diabetes...
  13. Obesity: neural control of body weight and metabolism
    Barry E Levin; Fiscal Year: 2013
    ..in hypothalamic leptin receptor transcription, binding and downstream signaling pathways, food intake and body weight gain on chow and HE diet, carcass composition, expression of various mRNA and protein species will be used to ..
  14. Hypothalamic SIRT1 and Energy Balance
    Eduardo A Nillni; Fiscal Year: 2013
    ..mediated knock down of Sirt1 in the arcuate nucleus (ARC) of the hypothalamus decreases food intake and body weight gain. Therefore, this proposal provides a novel view assigned to Sirt1 as a cellular energy sensor regulating energy ..
  15. Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome Risk
    PEI AN SHIH; Fiscal Year: 2013
    ....
  16. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..Use of statins, aspirin, and NSAID's and of insulinemia (weight and weight gain, dietary insulin index, plasma C-peptide, and adiponectin) will also be examined detail...
  17. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..Available literature suggests that substantial weight gain and other physiological changes during the short period of pregnancy may be associated with increased snoring, ..
  18. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..in older adults may be in understanding how age-related changes in body composition, in addition to excess weight gain, affect cardiometabolic risk factors and functional status...
  19. NPC1L1 and Metabolic Diseases
    Liqing Yu; Fiscal Year: 2013
    ..intestine to L1KO mice, thereby re-establishing intestinal NPC1L1 expression, and determine if this will rescue weight gain in L1KO mice...
  20. The Role of Substrate Metabolism and Macrophage Activation in Obesity
    Amy Johnson; Fiscal Year: 2013
    ..classically activated M1 macrophage cells of the innate immune system infiltrate adipose tissue at the onset of weight gain contributing to the inflammatory state of fat, ultimately resulting in systemic insulin resistance, while ..
  21. Growth hormone and adult physiology
    Rhonda D Kineman; Fiscal Year: 2013
    ..Circulating GH levels also decline with weight gain, independent of age...
  22. Diet Quality and CVD Risk Factors in a Family Based Weight Management Study
    Alice H Lichtenstein; Fiscal Year: 2013
    ..they will provide objective measures for the effectiveness of a family-based program designed to prevent excess weight gain in high-risk children and potential 'spill-over'effects in the mothers/female guardians of the ..
  23. Leptin function &resistance in midbrain VTA &SN in reward eating &obesity
    YI NONE ZHANG; Fiscal Year: 2013
    ..1) leptin activation of the VTA has a greater counter-regulatory function against HF intake and associated weight gain than that of the forebrain arcuate nucleus (ARC) of the hypothalamus;(2) a new physiological function of leptin ..
  24. Mechanisms of diet-induced leptin resistance in ARC and VTA
    Philip J Scarpace; Fiscal Year: 2013
    ..Furthermore, disruptions in both pathways are necessary to promote weight gain. We will test these hypotheses in male Sprague Dawley rats by examining the neural regulation of food intake ..
  25. Role of NPC1L1 in regulating energy metabolism, nutrient utilization & weight gai
    Philip N Howles; Fiscal Year: 2010
    ..Reduced fat absorption may account for part of the difference in weight gain, but additional mechanisms, including increased energy expenditure, may also confer protection against diabetes ..
  26. Interventions Against the Molecular Etiology of BMPR2-induced PAH
    James D West; Fiscal Year: 2013
    ..This paradoxically causes some GR-dependent agonist effects, thus weight gain and high blood glucose in BMPR2 mutant humans and mice, but causes inability to signal through others, leaving ..
  27. Remodeling of Lipid Metabolism by Dietary Methionine Restriction
    ERIC PAUL PLAISANCE; Fiscal Year: 2012
    ....
  28. Metabolic Syndrome and Breast Cancer: Effects of a Combined Exercise Intervention
    Christina Dieli-Conwright; Fiscal Year: 2013
    ..However, serious breast cancer treatment side effects such as weight gain persist during survivorship and present an increased risk of developing metabolic-related diseases including ..
  29. Neuroendocrine Response to Gastric Bypass in Nonhuman Primates
    Randy J Seeley; Fiscal Year: 2010
    ..effects of RYGB in the Rhesus macaque, a species of NHP that, like many humans, is susceptible to the weight gain and diabetes-promoting effects of a high fat diet...
  30. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..role in bone metabolism, vitamin D also has anti-adipogenic properties which could protect against weight gain, and is positively associated with muscle strength and physical functioning, which could support the adoption ..
  31. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..measured by testicular volume and Tanner stages);2) somatic growth, specifically height, height velocity, weight gain, and BMI;3) altered serum concentrations of hormones that regulate somatic growth and pubertal development (..
  32. Sympathetic Regulation of AMPK in the control of non-shivering thermogenesis
    Jacob D Mulligan; Fiscal Year: 2012
    ..The third aim is to test the hypothesis that chronic weight gain increases caloric expenditure of BAT via an AMPK-mediated increase in brown adipocyte mitochondrial biogenesis...
  33. Maternal Hyperinsulinemia and Fetal Programming
    Mulchand S Patel; Fiscal Year: 2011
    ..achieved by dietary or pharmacological interventions imposed on 1-HC female rats to reduce hyperphagia and body weight gain, will reverse the transgenerational effect for 2-HC offspring...
  34. Imaging Strategies to Measure Brown Fat and Its Activity
    C Ronald Kahn; Fiscal Year: 2010
    ..studies suggest that in addition to its role in heat generation, BAT may also play a role in protection from weight gain and insulin resistance in both rodents and humans. Indeed, because of its very high metabolic activity...
  35. The Role of Estradiol and Sex in the Effects of Ghrelin on Meal Patterns and Fos-
    PETER BUTERA; Fiscal Year: 2009
    ..between ghrelin and estradiol may underlie the inhibitory effects of estradiol on feeding behavior and the weight gain caused by ovariectomy and estrogen withdrawal...
  36. Novel High Affinity and Long-Acting Bovine FSH Analogs for Veterinary Superovulat
    BRUCE DALE WEINTRAUB; Fiscal Year: 2012
    ..in vivo by pK studies in mice and/or rats as well as the classic Steelman-Pohley FSH bioassay of ovarian weight gain plus histological analysis of antral follicle number and size. 4...
  37. Exercise, Breast Cancer Prevention, and Mechanisms
    Henry J Thompson; Fiscal Year: 2013
    ..However, the focus on PA to control weight gain, while critical, tends to distract attention from the fact that 40% of women are an appropriate weight for ..
  38. NKT cells, fatty acids, and insulin resistance
    CURTIS LEE GABRIEL; Fiscal Year: 2010
    ..Specifically, we will measure weight gain, body composition, insulin resistance, and expression of pro-inflammatory genes in adipose tissue...
  39. Liver cancer risk and prevention among persons living with HIV/AIDS
    LESLEY SUEJEAN PARK; Fiscal Year: 2013
    ..While hepatitis B virus and hepatitis C virus treatment, prevention of weight gain, and hazardous alcohol consumption cessation are hypothesized to contribute to liver cancer prevention, it has ..
  40. Weight management for improved pregnancy outcomes
    Victor J Stevens; Fiscal Year: 2012
    ..Given the serious consequences of added weight gain during pregnancy for obese women, such as gestational diabetes, pre-eclampsia, or cesarean delivery, the best ..
  41. Food Environment, Diet Quality and Disparities in Obesity
    Adam Drewnowski; Fiscal Year: 2013
    ..main aim of the study is to assess the impact of SEP, environmental, and dietary variables on obesity and body weight gain. The hypothesis is that low dietary quality and low diet cost will be associated with prevalent obesity and ..
  42. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ..similar to the Metabolic Syndrome;in which they develop hyperglycemia, hyperlipidemia, hyperinsulinemia and weight gain. On the other hand, our most recent data suggest that both FKBP51 and PP5 have similar modulatory effects on GR...
  43. The Effect of Behavioral and Physiological Factors on Obesity Risk in Children
    Karen B Dorsey; Fiscal Year: 2012
    ..that her limited knowledge of nutrition, physical activity, and other physiological processes that determine weight gain left her ill prepared to help her overweight patients...
  44. DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASE
    Frank B Hu; Fiscal Year: 2013
    ..competing renewal are to illuminate the long-term relationships among overall diet quality, energy balance, weight gain, and cardiovascular disease (CVD) risk in the Nurses'Health Study (NHS), NHS II, and Health Professionals ..
  45. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
    ..Numerous studies have convincingly linked asthma and obesity, and demonstrated increased obstruction with weight gain and decreased obstruction with weight loss. However, the mechanisms that underlie this linkage are not known...
  46. Phase III Study Comparing Albumin and Hetastarch Therapy in Acute Lung Injury
    Gregory S Martin; Fiscal Year: 2013
    ..It is now well established that fluid overload, weight gain, and reductions in oncotic pressure are deleterious factors in ALI...
  47. A Mindfulness-Based Approach to the Treatment of Obesity and Diabetes
    Carla K Miller; Fiscal Year: 2010
    The rising prevalence of diabetes parallels the rise in obesity in the U.S. The prevention of weight gain and promotion of weight loss using novel approaches among people with diabetes is needed to reduce the morbidity and mortality ..
  48. GWA Mapping: Maternal Metabolism-Birth Weight Interactions
    WILLIAM LOWE; Fiscal Year: 2009
    ..circumference and adiposity) allowing for other known influences such as gestational age, parity, and maternal weight gain. (2) To apply the above approaches to identify genetic variation that impacts maternal glucose tolerance at ~28 ..
  49. Translational Diebetes Prevention in GDM
    Assiamira Ferrara; Fiscal Year: 2013
    ..Goals for the intervention during pregnancy (Phase I) are to help women comply with the IOM guidelines for weight gain. Phase I will be delivered through 1 individual in-person session and 2 telephone counseling contacts...
  50. Bisphenol A and Children's Growth & Development
    KIM G contact HARLEY; Fiscal Year: 2010
    ..reproductive development, including sexually-dimorphic alterations in brain structure and behavior;increased weight gain;and earlier puberty. Because of these health concerns, several countries and U.S...
  51. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2013
    ..We will determine alterations in colitis severity by measuring changes in body weight gain, mortality, histological damage, and fluid leak. Specific Aim 2...
  52. Pregnancy and EARly Lifestyle improvement Study (PEARLS)
    Kaumudi J Joshipura; Fiscal Year: 2013
    ..evaluate whether the combined intervention will: (1) increase the percent of women with adequate gestational weight gain, (2) optimize early infant growth and (3) achieve adequate retention and compliance...
  53. Evaluating Economic Subsidies To Improve Dietary Intake Among Low Income Families
    Marian L Fitzgibbon; Fiscal Year: 2010
    ..and voucher redemption data with reported dietary intake, important social contextual variables, and child weight gain trajectory over the first 18 months of the policy (with informed consent)...
  54. Intravenous Protein Therapy for Treatment of Congenital Muscular Dystrophy
    Bradley L Hodges; Fiscal Year: 2010
    ..This will include assessment of more disease endpoints including weight gain, lifespan, locomotor activity and grip strength, creatine kinase, apoptosis, and histopathological changes...
  55. Weight gain, type 2 diabetes, and factors that affect neuroendocrine function
    EDWARD ANTONIO RUIZ-NARVAEZ; Fiscal Year: 2013
    ..We propose to prospectively assess whether the above- mentioned factors are associated with weight gain and incidence of T2D in AA women, and whether genetic variants in the FTO gene modify these associations...
  56. Nutrition, Deregulation of Imprinted Genes
    Cathrine Hoyo; Fiscal Year: 2013
    ..of imprinting and increased circulating concentrations of growth factors they encode, and subsequently, rapid weight gain in the offspring...
  57. Creation of Eating/Activity Environments by New Mothers
    Deborah Young Hyman; Fiscal Year: 2010
    ..We will also explore the relationship between presence or absence of the G-protein ss3 subunit C825 T and weight gain in the babies...
  58. Ethanol Regulates Vacuolar ATPase &PEDF
    Chuhan Chung; Fiscal Year: 2013
    ..3) Cerulein-induced pancreatitis results in impaired weight gain and increased collagen deposition in PEDF null mice compared to WT animals...
  59. Obesity and Metabolic Risk Disparities: Underlying Food Environment Factors
    Penny Gordon-Larsen; Fiscal Year: 2013
    ..and availability and access to away-from-home food eateries and food shopping options on diet, and in turn, weight gain and metabolic risk factors...
  60. Pathogenesis/Treatment-Inherited Cholesterol Deficiency
    Gordon L Watson; Fiscal Year: 2013
    ..Biochemical markers, dysmorphic features, and physiological indicators (e.g., survival rates, weight gain and photosensitivity) will all be monitored...
  61. Mechanisms of Programmed Gestational Hyperphagia
    MICHAEL GLENN ROSS; Fiscal Year: 2012
    ..model human obesity programming, as IUGR offspring of nutrient- restricted rat dams exhibit increased appetite, weight gain and the development of obesity...
  62. MECHANISMS FOR FETAL HEPATIC PROGRAMMING IN THE NON-HUMAN PRIMATE (NHP)
    Jacob E Friedman; Fiscal Year: 2010
    ..Associations between childhood obesity and maternal obesity without diabetes or weight gain during pregnancy have been suggested, but are less clear...
  63. Neuroendocrine Mechanisms of Developmental Massage Therapy in Preterm Infants
    Laurie Moyer Mileur; Fiscal Year: 2009
    ..Touch'or massage therapy is associated with decreased cortisol levels and improved weight gain in premature infants...
  64. DIETARY OMEGA-3 FATTY ACIDS, GENE EXPRESSION AND GROWTH
    William Heird; Fiscal Year: 2001
    Dietary omega3 fatty acids have been associated with higher rates of energy expenditure, lower rates of weight gain and/or lower rates of fat deposition in rodents as well as human infants and adults...
  65. EPIDEMIC HYPERTENSION IN NIGERIAN WORKERS
    Clareann Bunker; Fiscal Year: 1999
    ..5. Further analyses suggested that, above the BMI threshold, adult weight gain is a stronger determinant of blood pressure than pre-adult weight...
  66. Prevention of Overfeeding During Infancy
    Kathryn G Dewey; Fiscal Year: 2010
    ..One of the key risk factors for later obesity is a rapid rate of weight gain during infancy;related behavioral factors are parenting styles and associated infant feeding practices...
  67. MEGESTROL ACETATE FOR TREATMENT OF CANCER CACHEXIA
    David Heber; Fiscal Year: 1992
    ..In 1986, Tchekmedyian et.al. observed weight gain in 30 of 33 advanced breast cancer patients treated with megestrol acetate, a progestational steroid...
  68. Physical Activity and Diet in the Prevention of Obesity in Men and Women
    Howard D Sesso; Fiscal Year: 2010
    ..activity, as well as dietary patterns that may be associated with the development of obesity and long-term weight gain during middle and late adulthood...
  69. HYPOTHALAMIC NEUROTRANSMITTER SYSTEMS & EATING BEHAVIOR
    SARAH LEIBOWITZ; Fiscal Year: 2004
    ..Another factor to consider is individual predisposition to weight gain, due to genetic or early environmental influences...
  70. METABOLIC ASPECTS OF BODY WEIGHT CHANGE IN DEPRESSION
    Madelyn Fernstrom; Fiscal Year: 1991
    Antidepressant treatment is reputed to be associated with unwanted, excessive weight gain. Regulation of body weight is a complex problem and can result from increase caloric intake, decreased caloric expenditure, or both...
  71. Understanding the Rise of Obesity among Immigrants: A Pilot Study
    Gilbert Gee; Fiscal Year: 2010
    ..S. This convergence suggests that weight gain is occurring faster among immigrants...
  72. Molecular Mechanisms Mediating Resistance to Leptin Signaling During Fat Gain
    Virend Somers; Fiscal Year: 2009
    ..intervention against obesity lie in the recognition of novel mechanisms involved during the initial stages of weight gain in humans...
  73. STRENGTH--Survivor TRaining for ENhancinG Total Health
    Wendy Demark Wahnefried; Fiscal Year: 2002
    b>Weight gain is a common side effect that accompanies adjuvant chemotherapy for breast cancer...
  74. COMBINING SCHEDULED REDUCTION WITH WEIGHT CONTROL
    William Riley; Fiscal Year: 1999
    ..computer and a written program guide, will be targeted to consumers, primarily women, for whom concern over weight gain is a significant impediment to successful smoking cessation...
  75. EXERCISE AND DIET INTERVENTION AFTER LIVER TRANSPLANT
    Patricia Painter; Fiscal Year: 2000
    ..functioning and frequently report symptoms related to muscle weakness and fatigue and are at risk for excessive weight gain. Cardiovascular risk is also elevated...
  76. Biopsychosocial determinants of weight gain in Black first-year college women
    Jennifer Webb; Fiscal Year: 2010
    ..g., weight gain, sedentary behaviors) and protection (e.g...
  77. Massaging Preterm Infants Enhances Growth
    Tiffany Field; Fiscal Year: 2006
    A number of studies have documented an average of 47 percent greater weight gain in preterm neonates following massage therapy. Our currently funded study suggests that massage therapy increases vagal activity, oxytocin, and IGF-1...
  78. HEALTHY WEIGHT MANAGEMENT FOR BREAST CANCER SURVIVORS
    Cheryl Rock; Fiscal Year: 2003
    b>Weight gain commonly occurs in women following the diagnosis of breast cancer. Post-diagnosis weight gain may increase risk for recurrence, and obesity at diagnosis of breast cancer is an established negative prognostic factor...
  79. Effect Of Weight-Increased Psychotropic Medications on Appetite Regulation
    KIMBERLY ANN BROWNLEY; Fiscal Year: 2010
    ..treated with second-generation ('atypical') antipsychotics (SGA) frequently experience severe weight gain that leads to obesity and obesity-related disorders, interferes with medication compliance, and necessitates ..
  80. Role of hypothalamic PPAR-gamma in the control of food intake and body weight
    DAVID ALEXANDER SARRUF; Fiscal Year: 2010
    ..Despite their impressive benefits, the thiazoladinedione (TZD) class of synthetic PPARy agonists also cause weight gain and fat accumulation...
  81. STN/Three Individual Projects: COATS, METS, CRSTN
    Scott Stroup; Fiscal Year: 2009
    ..There will be monitoring for and management of weight gain, insulin resistance, cholesterol elevation, and extrapyramidal side effects (EPSE) using pre-determined and ..