birth weight

Summary

Summary: The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.

Top Publications

  1. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  2. doi Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial
    Lars Ake Persson
    Department of Women s and Children s Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden
    JAMA 307:2050-9. 2012
  3. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
  4. pmc Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts
    Shane A Norris
    Medical Research Council Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Diabetes Care 35:72-9. 2012
  5. doi Birth weight and subsequent risk of obesity: a systematic review and meta-analysis
    Z B Yu
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital, Nanjing Medical University, Nanjing, China
    Obes Rev 12:525-42. 2011
  6. ncbi Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus
    Charlotte M Boney
    Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Brown Medical School and Hasbro Children s Hospital, Providence, Rhode Island, USA
    Pediatrics 115:e290-6. 2005
  7. ncbi On the importance--and the unimportance--of birthweight
    A J Wilcox
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham NC 27709, USA
    Int J Epidemiol 30:1233-41. 2001
  8. ncbi The developmental origins of adult disease
    D J P Barker
    University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
    J Am Coll Nutr 23:588S-595S. 2004
  9. pmc Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 111:201-5. 2003
  10. ncbi SNAP-II and SNAPPE-II: Simplified newborn illness severity and mortality risk scores
    D K Richardson
    Joint Program in Neonatology, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital and Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA
    J Pediatr 138:92-100. 2001

Detail Information

Publications408 found, 100 shown here

  1. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  2. doi Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial
    Lars Ake Persson
    Department of Women s and Children s Health, International Maternal and Child Health, Uppsala University, Uppsala, Sweden
    JAMA 307:2050-9. 2012
    ..Nutritional insult in fetal life and small size at birth are common in low-income countries and are associated with serious health consequences...
  3. pmc A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass...
  4. pmc Size at birth, weight gain in infancy and childhood, and adult diabetes risk in five low- or middle-income country birth cohorts
    Shane A Norris
    Medical Research Council Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
    Diabetes Care 35:72-9. 2012
    We examined associations of birth weight and weight gain in infancy and early childhood with type 2 diabetes (DM) risk in five cohorts from low- and middle-income countries.
  5. doi Birth weight and subsequent risk of obesity: a systematic review and meta-analysis
    Z B Yu
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital, Nanjing Medical University, Nanjing, China
    Obes Rev 12:525-42. 2011
    This report describes the association between birth weight (BW) and obesity. Screening of 478 citations from five electronic databases resulted in the inclusion of 33 studies, most of medium quality...
  6. ncbi Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus
    Charlotte M Boney
    Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Brown Medical School and Hasbro Children s Hospital, Providence, Rhode Island, USA
    Pediatrics 115:e290-6. 2005
    ..We examined the development of MS among large-for-gestational-age (LGA) and appropriate-for-gestational age (AGA) children...
  7. ncbi On the importance--and the unimportance--of birthweight
    A J Wilcox
    Epidemiology Branch, National Institute of Environmental Health Sciences, Durham NC 27709, USA
    Int J Epidemiol 30:1233-41. 2001
    ..While the ordinary approaches to birthweight are not well grounded, the links between birthweight and a range of health outcomes may nonetheless reflect the workings of biological mechanisms with implications for human health...
  8. ncbi The developmental origins of adult disease
    D J P Barker
    University of Southampton, MRC Epidemiology Centre, Southampton General Hospital, Southampton, SO16 6YD, England
    J Am Coll Nutr 23:588S-595S. 2004
    ..A new vision of optimal early human development is emerging which takes account of both short and long-term outcomes...
  9. pmc Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 111:201-5. 2003
    ..Among African Americans, high prenatal exposure to PAHs was associated with lower birth weight (p = 0.003) and smaller head circumference (p = 0.01) after adjusting for potential confounders...
  10. ncbi SNAP-II and SNAPPE-II: Simplified newborn illness severity and mortality risk scores
    D K Richardson
    Joint Program in Neonatology, Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital and Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA
    J Pediatr 138:92-100. 2001
    OBJECTIVES: Illness severity scores for newborns are complex and restricted by birth weight and have dated validations and calibrations. We developed and validated simplified neonatal illness severity and mortality risk scores...
  11. ncbi Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: longitudinal birth cohort study and analysis
    Ken K L Ong
    Department of Paediatrics, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Pediatr Res 52:863-7. 2002
    ..The sequence of fetal growth restraint and postnatal catch-up growth may predispose to obesity risk in this contemporary population...
  12. pmc Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University Medical Center, 2200 West Main Street, Ste 600, Durham, NC 27705, USA
    Cancer Causes Control 23:635-45. 2012
    ..We examined associations among DNA methylation at IGF2 differentially methylated regions (DMRs), circulating IGF2 protein concentrations in umbilical cord blood (UCB) and birth weight in newborns.
  13. pmc A nearly continuous measure of birth weight for gestational age using a United States national reference
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, USA
    BMC Pediatr 3:6. 2003
    Fully understanding the determinants and sequelae of fetal growth requires a continuous measure of birth weight adjusted for gestational age...
  14. ncbi Weights of placentae from small-for-gestational age infants revisited
    S Heinonen
    Department of Obstetrics and Gynecology, University Hospital of Kuopio, Finland
    Placenta 22:399-404. 2001
    ..Future studies should evaluate whether growth restriction could be reversed by therapeutic approaches increasing placental weight...
  15. pmc Fetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study
    T J Parsons
    Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH, UK
    BMJ 323:1331-5. 2001
    To determine the influence of birth weight on body mass index at different stages of later life; whether this relation persists after accounting for potential confounding factors; and the role of indicators of fetal growth (birth weight ..
  16. ncbi Effects of Plasmodium vivax malaria in pregnancy
    F Nosten
    Shokio Malaria Research Unit, Mae Sot, Thailand
    Lancet 354:546-9. 1999
    ..P. falciparum infection has harmful effects in pregnancy, but the effects of P. vivax have not been characterised. We investigated the effects of P. vivax infection during pregnancy...
  17. ncbi Fetal origins of adult disease: strength of effects and biological basis
    D J P Barker
    Medical Research Council Environmental Epidemiology Unit, Southampton SO16 6YD, UK
    Int J Epidemiol 31:1235-9. 2002
    ....
  18. pmc Persistent epigenetic differences associated with prenatal exposure to famine in humans
    Bastiaan T Heijmans
    Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
    Proc Natl Acad Sci U S A 105:17046-9. 2008
    ..These data are the first to contribute empirical support for the hypothesis that early-life environmental conditions can cause epigenetic changes in humans that persist throughout life...
  19. doi Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh
    Anisur Rahman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka, Bangladesh
    Am J Epidemiol 169:304-12. 2009
    The authors evaluated the association of prenatal arsenic exposure with size at birth (birth weight, birth length, head and chest circumferences)...
  20. pmc Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity
    Payam Dadvand
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health Perspect 121:267-373. 2013
    ..A growing body of evidence has associated maternal exposure to air pollution with adverse effects on fetal growth; however, the existing literature is inconsistent...
  21. doi Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management
    Francesc Figueras
    Department of Maternal Fetal Medicine, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Am J Obstet Gynecol 204:288-300. 2011
    ..Appropriate protocols based on available evidence as well as individualized clinical assessment are essential to ensure good management and timely delivery...
  22. doi Differences in the implications of maternal lipids on fetal metabolism and growth between gestational diabetes mellitus and control pregnancies
    U M Schaefer-Graf
    Berlin Center for Diabetes in Pregnancy, Department of Obstetrics and Gynecology, St Joseph s Hospital, Berlin, Germany
    Diabet Med 28:1053-9. 2011
    ....
  23. ncbi Regression models for twin studies: a critical review
    John B Carlin
    Clinical Epidemiology and Biostatistics Unit, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 34:1089-99. 2005
    ..and issues of interpretation are illustrated using an example from a recent study of the association between birth weight and cord blood erythropoietin...
  24. pmc Does birth weight influence physical activity in youth? A combined analysis of four studies using objectively measured physical activity
    Charlotte L Ridgway
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, United Kingdom
    PLoS ONE 6:e16125. 2011
    ..Furthermore, individuals with very low birth weight report lower levels of physical activity as adults...
  25. ncbi A new and improved population-based Canadian reference for birth weight for gestational age
    M S Kramer
    Department of Pediatrics, McGill University Faculty of Medicine, Montreal, Canada
    Pediatrics 108:E35. 2001
    ..1 or more major methodologic problems, including errors in reported gestational age, biologically implausible birth weight for gestational age, insufficient sample sizes at low gestational age, single-hospital or other non-population-..
  26. doi Birthweight and mortality in adulthood: a systematic review and meta-analysis
    Kari R Risnes
    Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway
    Int J Epidemiol 40:647-61. 2011
    ..The net effect of birth size on long-term mortality has only been assessed in individual studies, with conflicting results...
  27. doi Early growth patterns and long-term obesity risk
    Nicolas Stettler
    The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Clin Nutr Metab Care 13:294-9. 2010
    ..These data are important because the potential programming of obesity in early life provides hope for new prevention strategies targeting early growth for long-term benefits...
  28. ncbi Infant growth and later body composition: evidence from the 4-component model
    Sirinuch Chomtho
    The Medical Research Council, Childhood Nutrition Research Centre, Institute of Child Health, University College London, London, United Kingdom
    Am J Clin Nutr 87:1776-84. 2008
    ..Rapid weight gain in infancy is associated with higher body mass index in later life, but its relation with individual body-composition components remains unclear...
  29. ncbi Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia
    Teresa A Hillier
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Diabetes Care 30:2287-92. 2007
    ..The purpose of this study was to determine how the range of measured maternal glycemia in pregnancy relates to risk of obesity in childhood...
  30. ncbi Birth weight in relation to morbidity and mortality among newborn infants
    D D McIntire
    Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    N Engl J Med 340:1234-8. 1999
    At any given gestational age, infants with low birth weight have relatively high morbidity and mortality...
  31. doi The effects of maternal body mass index on pregnancy outcome
    A S Khashan
    The Anu Research Centre, Department of Obstetrics and Gynaecology, Cork University Maternity Hospital, University College Cork, Wilton, Cork, Ireland
    Eur J Epidemiol 24:697-705. 2009
    ..Overweight and obese women have a higher risk of macrosomia and Caesarean delivery and lower risk of preterm delivery. The mechanism underlying this association is unclear and is worthy of further investigation...
  32. ncbi Glomerular number and size in autopsy kidneys: the relationship to birth weight
    Michael Hughson
    University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Kidney Int 63:2113-22. 2003
    ..Higher rates of low birth weight (LBW) among African Americans is suggested to predispose African Americans to the higher risk, possibly by ..
  33. pmc A cohort study of traffic-related air pollution impacts on birth outcomes
    Michael Brauer
    School of Environmental Health, The University of British Columbia, 2206 East Mall, Vancouver BC V6T1Z3 Canada
    Environ Health Perspect 116:680-6. 2008
    ..Evidence suggests that air pollution exposure adversely affects pregnancy outcomes. Few studies have examined individual-level intraurban exposure contrasts...
  34. ncbi Neonatal anthropometry: the thin-fat Indian baby. The Pune Maternal Nutrition Study
    C S Yajnik
    King Edward Memorial Hospital, Rasta Peth, Pune, India
    Int J Obes Relat Metab Disord 27:173-80. 2003
    ..To examine body size and fat measurements of babies born in rural India and compare them with white Caucasian babies born in an industrialised country...
  35. pmc Sex differences in the developmental origins of hypertension and cardiorenal disease
    Jeffrey S Gilbert
    Department of Physiology and Pharmacology, University of Minnesota Medical School Duluth, Duluth, MN 55812, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1941-52. 2008
    ..hypothesis derives from clinical observations, indicating long-term health consequences for persons of low birth weight. There is growing evidence, primarily from animal studies, that supports the idea that processes put in motion ..
  36. pmc Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta
    Amanda C Filiberto
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Epigenetics 6:566-72. 2011
    ..Our work is one of the first to link infant growth as a measure of the intrauterine environment and epigenetic alterations to the GR and suggests that DNA methylation may be a critical determinant of placental function...
  37. ncbi Adult consequences of fetal growth restriction
    David J P Barker
    Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Clin Obstet Gynecol 49:270-83. 2006
    ..Cardiovascular disease and type 2 diabetes arise through a series of interactions between environmental influences and the pathways of development that precede them...
  38. ncbi Genetic and environmental influences on birth weight, birth length, head circumference, and gestational age by use of population-based parent-offspring data
    Astrid Lunde
    Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway
    Am J Epidemiol 165:734-41. 2007
    Familial correlations in birth weight and gestational age have been explained by fetal and maternal genetic factors, mainly in studies on offspring of twins...
  39. pmc Malaria in pregnancy: the difficulties in measuring birthweight
    M J Rijken
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    BJOG 118:671-8. 2011
    ..We performed a structured search of the literature using 'malaria', 'pregnancy' and 'birth weight' as search terms...
  40. ncbi Programming of body composition by early growth and nutrition
    Jonathan C K Wells
    Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Proc Nutr Soc 66:423-34. 2007
    ..Early studies reporting positive associations between birth weight and adult BMI suggested a tendency for large babies to become obese adults...
  41. pmc Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria
    Catherine O Falade
    Department of Clinical Pharmacology, University College Hospital, Ibadan, Nigeria
    Malar J 6:88. 2007
    ..This study sets out to evaluate the effectiveness of IPT-SP in the prevention of maternal and placental malaria in parturient mothers in Ibadan, Nigeria, where the risk of malaria is present all year round...
  42. pmc Pre-pregnancy body mass index in relation to infant birth weight and offspring overweight/obesity: a systematic review and meta-analysis
    Zhangbin Yu
    State Key Laboratory of Reproductive Medicine, Department of Pediatrics, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, China
    PLoS ONE 8:e61627. 2013
    ..However, there is not a meta-analysis to determine if pre-pregnancy body mass index (BMI) is related to infant birth weight (BW) and offspring overweight/obesity.
  43. ncbi The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature
    R R Huxley
    Division of Public Health and Primary Health Care, Institute of Health Sciences, Oxford, UK
    J Hypertens 18:815-31. 2000
    ....
  44. pmc Impact of maternal body mass index on neonatal outcome
    P Kalk
    Department of Pharmacolcgy and Toxicology, Charite, Hessische Str 3 4, 10115 Berlin, Germany
    Eur J Med Res 14:216-22. 2009
    ..An increased maternal BMI is known to be associated with admission of the newborn to a neonatal care unit. The reasons and impact of this admission on fetal outcome, however, are unknown so far...
  45. doi Birth weight and risk of type 2 diabetes: a systematic review
    Peter H Whincup
    Division of Community Health Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, England
    JAMA 300:2886-97. 2008
    Low birth weight is implicated as a risk factor for type 2 diabetes. However, the strength, consistency, independence, and shape of the association have not been systematically examined.
  46. pmc Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight
    Miho Ishida
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, UK
    Am J Hum Genet 90:715-9. 2012
    b>Birth weight is an important indicator of both perinatal and adult health, but little is known about the genetic factors contributing to its variability...
  47. pmc Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight
    Connie J Mulligan
    Department of Anthropology, University of Florida, Gainesville, FL, USA
    Epigenetics 7:853-7. 2012
    ..we show a significant correlation between culturally relevant measures of maternal prenatal stress, newborn birth weight and newborn methylation in the promoter of the glucocorticoid receptor NR3C1...
  48. pmc Airborne PM2.5 chemical components and low birth weight in the northeastern and mid-Atlantic regions of the United States
    Keita Ebisu
    School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA
    Environ Health Perspect 120:1746-52. 2012
    ..Chemical components of particulate matter ≤ 2.5 µm (PM2.5) composition are spatially -heterogeneous, which might contribute to discrepancies across PM2.5 studies...
  49. doi In utero exposure to bisphenol-A and its effect on birth weight of offspring
    Maohua Miao
    Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, CA 94612, United States
    Reprod Toxicol 32:64-8. 2011
    To examine the effect of in utero BPA exposure on the birth weight of offspring, a total of 587 children from families in which parent(s) did or did not have occupational exposure to BPA were examined...
  50. pmc Effects of cord serum insulin, IGF-II, IGFBP-2, IL-6 and cortisol concentrations on human birth weight and length: pilot study
    Arianna Smerieri
    Department of Paediatrics, University Hospital of Parma, Parma, Italy
    PLoS ONE 6:e29562. 2011
    ..This study aimed at establishing and clarifying the effect of cord serum insulin, IGF-II, IGFBP-2, cortisol and IL-6 concentrations on birth length and weight...
  51. pmc Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris)
    Marie Pedersen
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health Perspect 120:1739-45. 2012
    ..Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents...
  52. ncbi The influence of obesity and diabetes on the prevalence of macrosomia
    Hugh M Ehrenberg
    Case Western Reserve University School of Medicine, Department of Reproductive Biology, MetroHealth Medical Center, Cleveland, Ohio, USA
    Am J Obstet Gynecol 191:964-8. 2004
    ..This study was undertaken to determine the relative contribution of abnormal pregravid maternal body habitus and diabetes on the prevalence of large-for-gestational-age infants...
  53. ncbi Pre-pregnancy body mass index, gestational weight gain, and other maternal characteristics in relation to infant birth weight
    Ihunnaya O Frederick
    Department of Health Services, University of Washington School of Public Health and Community Medicine, Seattle, WA, USA
    Matern Child Health J 12:557-67. 2008
    Infant birth weight is influenced by modifiable maternal pre-pregnancy behaviors and characteristics...
  54. pmc Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
    Cathy E Elks
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Med 7:e1000284. 2010
    ..Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity...
  55. pmc Childhood body-mass index and the risk of coronary heart disease in adulthood
    Jennifer L Baker
    Institute of Preventive Medicine, Center for Health and Society, Copenhagen, Denmark
    N Engl J Med 357:2329-37. 2007
    ..Risk factors for coronary heart disease (CHD) are already identifiable in overweight children. The severity of the long-term effects of excess childhood weight on CHD, however, remains unknown...
  56. pmc Ambient air pollution and birth weight in full-term infants in Atlanta, 1994-2004
    Lyndsey A Darrow
    Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 119:731-7. 2011
    ..An emerging body of evidence suggests that ambient levels of air pollution during pregnancy are associated with fetal growth...
  57. doi Associations between fetal size, maternal {alpha}-tocopherol and childhood asthma
    Stephen W Turner
    Department of Child Health, University of Aberdeen, Royal Aberdeen Children s Hospital, Foresterhill, Aberdeen AB25 2ZG, UK
    Thorax 65:391-7. 2010
    ..002). CONCLUSIONS These findings support the concept of very early fetal programming of respiratory disease. Maternal vitamin E status may be one determinant for growth of the fetus and fetal lungs during early pregnancy...
  58. ncbi Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight
    Xiaobin Wang
    Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, 91 E Concord St, Maternity 4, Boston, MA 02118, USA
    JAMA 287:195-202. 2002
    ..Little is known about genetic susceptibility to cigarette smoke in relation to adverse pregnancy outcomes...
  59. doi Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy
    Hans G Richter
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Pineal Res 46:357-64. 2009
    ..Here, we investigated the effects of maternal treatment with melatonin on placental efficiency, fetal growth, birth weight and protein expression of placental oxidative stress markers in undernourished pregnancy...
  60. doi FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI
    Hao Mei
    Department of Epidemiology, Tulane University, New Orleans, LA, USA
    Hum Genet 128:589-96. 2010
    ..Knowledge is limited on FTO, modulating the association between birth weight and longitudinal change of BMI...
  61. ncbi Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group
    M F Cotch
    National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA
    Sex Transm Dis 24:353-60. 1997
    ..vaginalis at mid-gestation was significantly associated with low birth weight (odds ratio 1.3; 95% confidence interval 1.1 to 1.5), preterm delivery (odds ratio 1...
  62. ncbi Parental overweight, socioeconomic status and high birth weight are the major determinants of overweight and obesity in 5-7 y-old children: baseline data of the Kiel Obesity Prevention Study (KOPS)
    S Danielzik
    Institut fur Humanernahrung und Lebensmittelkunde, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Int J Obes Relat Metab Disord 28:1494-502. 2004
    ..To identify the major risk factors of overweight and obesity in prepubertal children...
  63. pmc Maternal blood manganese levels and infant birth weight
    Ami R Zota
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 20:367-73. 2009
    ..High manganese exposures have been associated with negative reproductive outcomes in animals, but few epidemiologic studies have examined the effects of human fetal manganese exposure...
  64. pmc Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain
    Ferran Ballester
    Center for Public Health Research CSISP, Conselleria de Sanitat, 46020, Valencia, Spain
    Environ Health 9:6. 2010
    ..The objective of this study was to assess the association between exposure to air pollution during pregnancy and anthropometric measures at birth in a cohort in Valencia, Spain...
  65. ncbi Maternal gestational diabetes, birth weight, and adolescent obesity
    Matthew W Gillman
    Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Pediatrics 111:e221-6. 2003
    ..Gestational diabetes mellitus (GDM) reflects a metabolically altered fetal environment associated with high birth weight, itself associated with later obesity...
  66. ncbi Early life factors and blood pressure at age 31 years in the 1966 northern Finland birth cohort
    Marjo Riitta Jarvelin
    Department of Epidemiology and Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom
    Hypertension 44:838-46. 2004
    Data on the birth weight-blood pressure relationship are inconsistent. Although an inverse association has been suggested in several large studies, interpretation is complicated by publication and other biases...
  67. pmc A multicenter, randomized trial of treatment for mild gestational diabetes
    Mark B Landon
    Department of Obstetrics and Gynecology, Ohio State University, Columbus, USA
    N Engl J Med 361:1339-48. 2009
    ..It is uncertain whether treatment of mild gestational diabetes mellitus improves pregnancy outcomes...
  68. ncbi Fetal programming of coronary heart disease
    David J P Barker
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, SO16 6YD, Southampton, UK
    Trends Endocrinol Metab 13:364-8. 2002
    ..Coronary heart disease appears to be a developmental disorder that originates through two widespread biological phenomena, developmental plasticity and compensatory growth...
  69. ncbi Deliveries, mothers and newborn infants in Sweden, 1973-2000. Trends in obstetrics as reported to the Swedish Medical Birth Register
    Viveca Odlind
    Center for Epidemiology, Swedish National Board of Health and Welfare, Stockholm, Sweden
    Acta Obstet Gynecol Scand 82:516-28. 2003
    ..The aim of this report is to present descriptive data from the Swedish Medical Birth Register (MBR) reflecting trends in obstetric and neonatal practices over three decades...
  70. doi Exercise training in pregnancy reduces offspring size without changes in maternal insulin sensitivity
    Sarah A Hopkins
    Liggins Institute, The University of Auckland, PO Box 92019, Auckland 1142, New Zealand
    J Clin Endocrinol Metab 95:2080-8. 2010
    ..Regular aerobic exercise, through an effect on maternal insulin sensitivity, may influence offspring size by regulating nutrient supply to the fetus...
  71. ncbi Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Center, Western General Hospital, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R34-8. 2005
    Epidemiological studies linking low birth weight and subsequent cardiometabolic disease have given rise to the hypothesis that events in fetal life permanently program subsequent cardiovascular risk...
  72. ncbi The influence of erythrocyte folate and serum vitamin B12 status on birth weight
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Nutr 93:593-9. 2005
    The extent to which maternal folate and vitamin B12 modulate infant birth weight is unclear. The present study investigated mothers in early gestation (mean 11.5 (sd 5.8) weeks) and neonates, at delivery...
  73. ncbi Placenta and fetal growth restriction
    Carolyn M Salafia
    Department of Epidemiology, Mailman School of Public Health, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Clin Obstet Gynecol 49:236-56. 2006
    ....
  74. ncbi Australian national birthweight percentiles by gestational age
    C L Roberts
    NSW Centre for Perinatal Health Services Research, Department of Obstetrics and Gynaecology, University of Sydney
    Med J Aust 170:114-8. 1999
    ..To develop national birthweight percentiles by gestational age for male and female singleton infants born in Australia, and to compare the birthweight percentiles of Indigenous and non-Indigenous infants...
  75. pmc Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke
    Susan K Murphy
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC 27708, USA
    Gene 494:36-43. 2012
    ..methylated regions (DMRs) regulating Insulin-like Growth Factor 2 (IGF2) and H19, and how this might relate to birth weight of infants born to 418 pregnant women. Smoking status was ascertained through self-report and medical records...
  76. doi Air pollution and birth outcomes: a systematic review
    Prakesh S Shah
    Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada
    Environ Int 37:498-516. 2011
    ....
  77. ncbi Effect of treatment of gestational diabetes mellitus on pregnancy outcomes
    Caroline A Crowther
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, Australia
    N Engl J Med 352:2477-86. 2005
    ..We conducted a randomized clinical trial to determine whether treatment of women with gestational diabetes mellitus reduced the risk of perinatal complications...
  78. doi A global reference for fetal-weight and birthweight percentiles
    Rafael T Mikolajczyk
    Department of Clinical Epidemiology, Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany
    Lancet 377:1855-61. 2011
    ..Our aim was to create a generic reference for fetal weight and birthweight that overcame these deficiencies and could be readily adapted to local populations...
  79. ncbi Increased fetal adiposity: a very sensitive marker of abnormal in utero development
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH 44109, USA
    Am J Obstet Gynecol 189:1698-704. 2003
    ....
  80. pmc Epidemiology of preterm birth
    Janet Tucker
    Dugald Baird Centre, Department of Obstetrics and Gynaecology, University of Aberdeen
    BMJ 329:675-8. 2004
  81. ncbi Placental monocyte infiltrates in response to Plasmodium falciparum malaria infection and their association with adverse pregnancy outcomes
    Stephen J Rogerson
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Am J Trop Med Hyg 68:115-9. 2003
    Maternal anemia and low birth weight (LBW) may complicate malaria in pregnancy, and placental monocyte infiltrates have been associated with LBW, and anecdotally with anemia. We examined placental pathology from 357 Malawian women...
  82. pmc Multiple micronutrient supplementation during pregnancy in low-income countries: a meta-analysis of effects on birth size and length of gestation
    Caroline H D Fall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Food Nutr Bull 30:S533-46. 2009
    ..Multiple micronutrient deficiencies are common among women in low-income countries and may adversely affect pregnancy outcomes...
  83. ncbi Activating mutations in the ABCC8 gene in neonatal diabetes mellitus
    Andrey P Babenko
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, USA
    N Engl J Med 355:456-66. 2006
    ..We hypothesized that activating mutations in ABCC8, which encodes SUR1, cause neonatal diabetes...
  84. ncbi Is birth weight related to later glucose and insulin metabolism?--A systematic review
    C A Newsome
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK
    Diabet Med 20:339-48. 2003
    To determine the relationship of birth weight to later glucose and insulin metabolism.
  85. ncbi Patterns of growth among children who later develop type 2 diabetes or its risk factors
    J G Eriksson
    National Public Health Institute, Helsinki, Finland
    Diabetologia 49:2853-8. 2006
    ..We studied fetal and childhood growth patterns that are associated with IGT and type 2 diabetes in adult life...
  86. pmc Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
    Rachel M Freathy
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
    Nat Genet 42:430-5. 2010
    To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,..
  87. ncbi The importance of the period of malarial infection during pregnancy on birth weight in tropical Africa
    Gilles Cottrell
    Institut de Recherche pour le Developpement, Paris, France
    Am J Trop Med Hyg 76:849-54. 2007
    Malaria in pregnant women is related to low birth weight (LBW), a factor contributing to infant mortality. Which period of infection during pregnancy leads to the most harmful consequences is unclear...
  88. pmc Prenatal insecticide exposures and birth weight and length among an urban minority cohort
    Robin M Whyatt
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 112:1125-32. 2004
    ..and that levels of the organophosphate chlorpyrifos in umbilical cord plasma were inversely associated with birth weight and length...
  89. pmc Executive functions of six-year-old boys with normal birth weight and gestational age
    Desiree Yee Ling Phua
    Singapore Institute for Clinical Sciences, The Agency for Science, Technology and Research, Singapore, Singapore
    PLoS ONE 7:e36502. 2012
    Impaired fetal development, reflected by low birth weight or prematurity, predicts an increased risk for psychopathology, especially attention deficit hyperactivity disorder (ADHD)...
  90. pmc Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): a meta-analysis within 12 European Birth Cohorts
    Eva Govarts
    Environmental Risk and Health, Flemish Institute for Technological Research VITO, Mol, Belgium
    Environ Health Perspect 120:162-70. 2012
    ..prenatal eXposure to the development of obesity later in life) projects, we examined the hypothesis that the combination of polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) adversely affects birth weight.
  91. doi Ambient air pollution, birth weight and preterm birth: a systematic review and meta-analysis
    David M Stieb
    Environmental Health Science and Research Bureau, Health Canada, 3rd Floor, 269 Laurier Ave W, Ottawa, ON, Canada K1A 0K9
    Environ Res 117:100-11. 2012
    Low birth weight and preterm birth have a substantial public health impact. Studies examining their association with outdoor air pollution were identified using searches of bibliographic databases and reference lists of relevant papers...
  92. doi Vitamin D status of low birth weight infants in Delhi: a comparative study
    Ramesh Agarwal
    All India Institute of Medical Sciences, Department of Pediatrics, Kasturba Hospital and Swami Dayanand Hospital, New Delhi 110029, India
    J Trop Pediatr 58:446-50. 2012
    To evaluate vitamin D status of preterm and term low birthweight (LBW) and term normal birth weight (NBW; weight ≥ 2500 g) infants at birth and in early infancy.
  93. pmc Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight
    Jessica Tyrrell
    European Centre for Environment and Human Health, University of Exeter, The Knowledge Spa, Truro, UK
    Hum Mol Genet 21:5344-58. 2012
    Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on ..
  94. pmc Birth weight- and fetal weight-growth restriction: impact on neurodevelopment
    Iris G Streimish
    Newborn Medicine, Newton Wellesley Hospital, Newton, MA, USA
    Early Hum Dev 88:765-71. 2012
    The newborn classified as growth-restricted on fetal weight curves, but not on birth weight curves, is classified prenatally as small for gestational age (SGA), but postnatally as appropriate for gestational age (AGA).
  95. ncbi Effect of early gestation feeding, birth weight, and gender of progeny on muscle fiber characteristics of pigs at slaughter
    G Bee
    Swiss Federal Research Station for Animal Production, Posieux 1726, Switzerland
    J Anim Sci 82:826-36. 2004
    Maternal nutrition and progeny birth weight affect muscle fiber development in the pig, thereby influencing early postnatal growth rate...
  96. pmc Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter?
    Linda S Adair
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Clin Nutr 89:1383-92. 2009
    ..Promoting catch-up growth in malnourished children has health benefits, but recent evidence suggests that accelerated child weight gain increases adult chronic disease risk...
  97. doi Maternal use of nicotine replacement therapy during pregnancy and offspring birthweight: a study within the Danish National Birth Cohort
    Tina H Lassen
    National Institute of Public Health, University of Southern Denmark, Copenhagen K, Denmark
    Paediatr Perinat Epidemiol 24:272-81. 2010
    ..The results of this study suggest that maternal use of NRT in pregnancy does not seriously affect birthweight, but there could be a negative effect on birthweight associated with simultaneous use of more than one type of NRT product...
  98. doi Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Res 111:125-35. 2011
    ..Maternal exposure to air pollution has been associated with adverse pregnancy outcomes. Few studies took into account the spatial and temporal variation of air pollution levels...
  99. pmc Levels of hexachlorobenzene (HCB) in breast milk in relation to birth weight in a Norwegian cohort
    Merete Eggesbø
    Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, N 0403 Oslo, Norway
    Environ Res 109:559-66. 2009
    ..However, its potential for reproductive toxicity in humans exposed to background levels has not been fully evaluated. Here we examined the association between maternal levels of HCB and their infants' birth weight.
  100. pmc Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans
    Anthony A Fryer
    Institute of Science and Technology in Medicine, Keele University School of Medicine, University Hospital of North Staffordshire Stoke on Trent, Staffordshire, UK
    Epigenetics 6:86-94. 2011
    Supplementation with folic acid during pregnancy is known to reduce the risk of neural tube defects and low birth weight. It is thought that folate and other one-carbon intermediates might secure these clinical effects via DNA methylation...
  101. doi Does birthweight predict bone mass in adulthood? A systematic review and meta-analysis
    J Baird
    MRC Epidemiology Resource Centre, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Osteoporos Int 22:1323-34. 2011
    ..Higher birthweight was associated with higher bone mineral content of the spine and hip in adult men and women at ages between 18 and 80 years across a range of settings...

Research Grants80

  1. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..Although multiple factors influence birth weight and size, air pollution exposure during pregnancy has been recently explored as a contributor...
  2. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..If successful, the health benefit will be large, as it is estimated that treating NEC alone (not including treating its later complications) adds $650 million to the annual health bill. ..
  3. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..8 NI/100 patients. The incidence increases with decreasing birth weight, being as high as 81.8 NI/100 patients in Very Low Birth Weight group (birth weight <1500 g)...
  4. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..and neonatal intensive care units (NICUs) have greatly raised the survival rate of at-risk, very low birth weight, and extremely premature infants, approximately 30,000 American babies under the age of one still die each year ..
  5. The effect of trichloroethylene exposure on adverse pregnancy outcomes
    Iman Hassan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Adverse pregnancy outcomes, including preterm birth, low birth weight, small for gestational age, intrauterine growth restriction and stillbirth,are significant determinants of infant mortality and ..
  6. Effect of Lactobacillus GG on gut permeability and microbiome in VLBW neonates
    ROSE MARIE VISCARDI; Fiscal Year: 2013
    ..enterocolitis (NEC) is a life-threatening, gastrointestinal emergency that occurs in 7 to 10% very low birth weight (VLBW, <1500 g) infants...
  7. Maternal One Carbon Metabolism and Low Birth Weight Infant
    Satish C Kalhan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Low birth weight (LBW) in infants, due to intrauterine growth retardation (IUGR), defined as weight <2500gms at term gestation, remains a critical problem in the developing countries and is a major ..
  8. Exploring persistent epigenetic changes after prenatal famine exposure in humans
    L H Lumey; Fiscal Year: 2010
    ..We have recently completed the first study in humans showing associations between early life factors such as birth weight and genomic DNA methylation measured in mid-life among women in a multiethnic birth cohort (1) and also the ..
  9. Outcomes of Infertility Treatments in Clinic and Population-Based Cohorts
    Joseph B Stanford; Fiscal Year: 2010
    ..However, epidemiologic studies have demonstrated higher incidence of preterm birth, low birth weight, and birth defects among children conceived through ART, when compared to children conceived naturally, even ..
  10. Role of Vimentin in Pathogenesis of CNS Inflammation
    Sheng He Huang; Fiscal Year: 2013
    ..of neonatal sepsis and meningitis (NSM), which remains a major cause of death in newborns, especially in low-birth weight infants. The ibeA locus is able to modulate expression of several virulence factors (e.g...
  11. The Impact of Sleep-Disordered Breathing on Adverse Pregnancy Outcomes
    LOUISE M O apos BRIEN; Fiscal Year: 2010
    ..extent to which SDB symptoms and signs predict adverse pregnancy outcomes, in particular pre-eclampsia and low birth weight. As an exploratory aim, Aim 4, will test whether self-reported habitual snoring is associated with an increased ..
  12. A Rapid Point-of-care Diagnostic for Neisseria gonorrhoeae STDs
    Richard F Selden; Fiscal Year: 2012
    ..Infection can also lead to sterility, ectopic pregnancy, and low birth weight. Approximately 10% of infected males and 50% of infected females are asymptomatic, hastening the spread of the ..
  13. Mechanisms of Airway Smooth Muscle Hypertrophy
    Marc B Hershenson; Fiscal Year: 2013
    ..appear to be potent biomarkers for the development of BPD;accounting for the potential influences of gender, birth weight and gestational age, isolation of mesenchymal stromal cells increased the adjusted odds ratio of BPD over 31-..
  14. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..Certain risk factors for poor outcomes are not altered by neonatal care such as socioeconomic status, sex, birth weight and gestational age at birth...
  15. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..Pregnancy outcomes (stillbirth, gestational length, preterm birth, birth weight, small for gestational age [SGA], birth length, head circumference, anogenital distance [AGD]), thyroid ..
  16. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..severe preterm (<32 weeks) and moderately preterm (32-37 weeks), and small-for-gestational-age (below 10% of birth weight for gestational age)...
  17. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ..e., low birth weight [LBW], and pre-term delivery [PTD]), a study is proposed to determine how inhalation of Cd-bearing NP (as CdO ..
  18. Predictors of Dietary Quality in Low-Income Pregnant Women
    Eileen R Fowles; Fiscal Year: 2010
    ..More effective targeted strategies initiated within this narrow window of time may reduce the number of low birth weight infants and improve obstetrical outcomes.
  19. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    ....
  20. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..Reported effects of background exposures in infants include reduced birth weight, less postnatal growth, impaired development, impaired immune-response, and lower thyroid hormone level...
  21. Genome-wide DNA Methylation Profiles Associated with Abnormal Intrauterine Growth
    Cristina Montagna; Fiscal Year: 2013
    ..Public Health Relevance: Infants born at the extremes of birth weight (i.e...
  22. Maternal Obesity and Gestational Diabetes: Impact on Metabolome
    William L Lowe; Fiscal Year: 2013
    ..metabolic signature in mothers and newborns is associated with newborn anthropometric traits at birth including birth weight, sum of skinfolds, and percent body fat...
  23. Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary Dysplasia
    Marlowe Eldridge; Fiscal Year: 2013
    ..Survival of very low birth weight (VLBW) infants has increased, however, these infants remain at risk for long-term medical problems including ..
  24. Click chemistry for novel antimicrobials against periodontal pathogens
    Valery V Fokin; Fiscal Year: 2010
    ....
  25. Genetics of Spontaneous Pelvic Organ Prolapse in the Mouse
    Jay E Reeder; Fiscal Year: 2010
    ..literature has correlated the development of pelvic organ prolapse with age, vaginal parity, increased infant birth weight, menopausal status, and genetic susceptibility...
  26. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2010
    ..One of the major causes of morbidity and mortality of low birth weight neonates relates to injury, inflammation, perforation and obstruction of the lower GI tract, which can be ..
  27. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ..to conception, early pregnancy loss (EPL), spontaneous abortion (SAB), and birth outcomes (gestational age, birth weight, length, and head circumference);(3) Preconception BMI and Micronutrients: including serum biomarkers of folate,..
  28. NICHD Maternal Fetal Medicine Units Network
    Geeta K Swamy; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Intervention strategies for maternal-fetal conditions such as prematurity, low birth weight, and preeclampsia remain controversial...
  29. Reducing Preterm Births in Underserved Pregnant Women
    JAMES G CHRISTIAN; Fiscal Year: 2011
    ..The rate of premature birth has increased by 36 percent since the early 1980s. Rates of low birth weight babies are higher in medically underserved and minority populations-even when issues such as access and ..
  30. Role of VEGF in Perinatal Hypertension
    STEVEN HERBERT ABMAN; Fiscal Year: 2013
    ..surfactant therapy and improved ventilator strategies, have markedly increased survival of extremely low birth weight infants...
  31. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2013
    ..One of the major causes of morbidity and mortality of low birth weight neonates relates to injury, inflammation, perforation and obstruction of the lower GI tract, which can be ..
  32. Biomarker Profiles for Early Diagnosis of Sepsis in Neonates
    JAMES PRESTON MAPES; Fiscal Year: 2011
    ..applicant): Sepsis is a frequent and serious problem in neonatal intensive care units, particularly in very low birth weight (VLBW) infants. Over 20% of all VLBW infants experience one or more episodes of late-onset sepsis...
  33. The Toxic Environment and the Epigenetics of Fetal Growth
    HEATHER HERSON BURRIS; Fiscal Year: 2013
    ..birth outcomes and known to affect DNA methylation, it remains unknown whether DNA methylation mediates arsenic-birth weight associations...
  34. Adipocyte Renin-Angiotensin System and Programming of Hypertension
    Mina Desai; Fiscal Year: 2010
    ..Our model of maternal food restriction during pregnancy results in low birth weight newborns that develop obesity and hypertension as adults...
  35. Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants
    Leslie A Parker; Fiscal Year: 2013
    ..importance of adequate enteral nutrition during the first few weeks following birth in premature very low birth weight (VLBW) infants is well known and necessary to facilitate optimal growth and development and reduce both ..
  36. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..trial in HIV-positive Tanzanian women showed a significant reduction in pre-term birth, fetal loss, and low birth weight. In addition, reduced rates of HIV transmission and morbidity were seen in subsets of infants born to ..
  37. Prenatal stress biology, infant body composition and obesity risk
    Sonja Entringer; Fiscal Year: 2013
    ..studies of fetal programming of obesity have relied on measures of either size at birth (such as low birth weight or small-for-gestational age birth), or fetal and early postnatal growth velocity, as markers of adverse ..
  38. A geostatistical framework for the multi-scale boundary analysis of space-time tr
    PIERRE E GOOVAERTS; Fiscal Year: 2013
    ..in the incidence of breast cancer late-stage diagnosis and adverse birth outcomes (mortality and low birth weight), as well as their temporal changes, in Michigan. Specifically, this project will accomplish three aims: 1...
  39. Genetic Manipulation of Unreaplasma spp. Infecting Humans using Synthetic Genomic
    JOHN IRVIN GLASS; Fiscal Year: 2013
    ..Learning how to transplant ureaplasma genomes could lead to our being able to do this for many other species including bacteria with unrealized pharmaceutical or industrial potential, for which we have no genetic tools. ..
  40. Mechanisms of Arsenic-Induced Developmental Toxicity
    Lisa Bain; Fiscal Year: 2009
    ..with adverse developmental outcomes such as stillbirths, spontaneous abortions, neonatal mortality, low birth weight, and delays in the use of musculature...
  41. Transforming Women's Health: Discovery, Development, and Delivery
    Ellen M Daley; Fiscal Year: 2012
    ..e. infant mortality, low birth weight, preterm birth) and are less likely to isit a dentist compared to women in the U.S...
  42. Cookstove Replacement for Prevention of ARI and Low Birthweight in Nepal
    JAMES MACK TIELSCH; Fiscal Year: 2012
    ..Low birth weight is highly prevalent in this population as well affecting approximately 30% of live born infants...
  43. GWA Mapping: Maternal Metabolism-Birth Weight Interactions
    WILLIAM LOWE; Fiscal Year: 2009
    ..cause of neonatal morbidity and mortality, and epidemiological data have established an association between birth weight and later risk of adult metabolic disease...
  44. Maternal Dietary Patterns and Child Weight Status
    Chantel L Martin; Fiscal Year: 2013
    ..and total cholesterol;(2) to examine the relationship between maternal dietary patterns during pregnancy and birth weight z-score;and (3) to investigate the association between maternal dietary patterns and child weight trajectory ..
  45. Mother Sibling Interactions
    Julie A Thompson; Fiscal Year: 2010
    ..3] Social development and health problems may be magnified when the newborn is a very low birth weight (VLBW) infant (less than 1500g) and requires additional attention from the mother...
  46. Optimal Prevention and Control of Periodontal Disease: The Periodontal Pocket Irr
    Thomas E Van Dyke; Fiscal Year: 2011
    ..S. adults (NIH estimate), and other health issues including heart disease, stroke, diabetes, pre-term low term birth weight, rheumatoid arthritis, and chronic kidney disease...
  47. Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in Vi
    DEBORAH ANN HANSEN; Fiscal Year: 2013
    ..Developmental endpoints such as structural birth defects, failed pregnancy, low birth weight, increased childhood cancers; and developmental, endocrine, and biochemical abnormalities have been reported in ..
  48. Prenatal Cocaine Exposure: Young Adult Follow Up
    Ruth Rose-Jacobs; Fiscal Year: 2013
    ..We consider as potential biologic factors among others: gender, birth weight, IUCE, age at assessment, &a novel composite measurement of overall level of intrauterine substance ..
  49. Effects of Maternal Influenza Immunization: A Field Trial in Guatemala'
    Saad B Omer; Fiscal Year: 2010
    ..The secondary infant/fetus outcomes include clinical influenza-like illness, prematurity, birth weight, delivery complications, pneumonia and severe pneumonia (per WHO Integrated Management of Childhood Illness ..
  50. Pregnancy and EARly Lifestyle improvement Study (PEARLS)
    Kaumudi J Joshipura; Fiscal Year: 2013
    ..Such intrauterine programming events affect birth weight and raise the offspring's risk trajectory for future obesity, type 2 diabetes, cardiovascular disease and ..
  51. Motivational Incentives to Reduce Secondhand Smoke in NICU Infants'Homes
    Angela L Stotts; Fiscal Year: 2013
    ..Preterm, low birth weight infants admitted to a Neonatal Intensive Care Unit (NICU) are especially vulnerable to the effects of SHSe, ..
  52. VCU Building Interdisciplinary Research Careers in Women's Health
    Jerome F Strauss; Fiscal Year: 2011
    ..interventions for pre-eclampsia, polycystic ovary syndrome, perinatal depression, preterm birth, low birth weight, vaginal bacteriosis, breast and ovarian cancer, and substance abuse...
  53. Repair of Bone Defects with Human Autologous Pluripotent Very Small Embryonic lik
    Russell S Taichman; Fiscal Year: 2013
    ..Furthermore, periodontitis is associated with systemic disorders such as diabetes mellitus, preterm low birth weight, and cardiovascular disease...
  54. Adverse Outcomes of Assisted Reproductive Technologies: Genetics or Epigenetics?
    Margareta Pisarska; Fiscal Year: 2013
    ..These pregnancies are at increased risk of adverse outcomes, including low birth weight, preeclampsia, placental abruption, placenta previa, preterm delivery, and perinatal mortality, many of which ..
  55. Weight gain, type 2 diabetes, and factors that affect neuroendocrine function
    EDWARD ANTONIO RUIZ-NARVAEZ; Fiscal Year: 2013
    ..AA women are less likely to have been breastfed, more likely to have been born preterm and with a low birth weight, and more likely to experience violence victimization, racism, depression, and sleep deprivation...
  56. Role of endocrine-disrupting chemicals and social stress on perinatal outcomes
    Ami R Zota; Fiscal Year: 2012
    ..and psychosocial stress on adverse perinatal outcomes, such as gestational hypertension, preterm birth, and low birth weight, and assess whether these effects are mediated via the thyroid system...
  57. Early Identification of Developmental Disorders in Infants
    B Eugene Parker; Fiscal Year: 2012
    ..with in vitro fertilization procedures, the number of preterm (<37 weeks postmenstrual age) very low birth weight (<1,500 g) neonates born is growing [34]...
  58. Trial of Late SURFactant (TOLSURF) to Prevent BPD - Clinical Coord Ctr
    ROBERTA ANDERSON BALLARD; Fiscal Year: 2013
    Bronchopulmonary dysplasia (BPD) is a major and costly cause of long-term pulmonary disability in extremely low birth weight (ELBW <1000 g and <30 weeks gestation) infants...
  59. Trial Of Late SURFactant (TOLSURF) to Prevent BPD-Data Coordinating Center
    Dennis M Black; Fiscal Year: 2013
    Bronchopulmonary dysplasia (BPD) is a major and costly cause of long-term pulmonary disability in extremely low birth weight (ELBW <1000 g and <30 weeks gestation) infants...
  60. Impact of Catecholamines to Insulin-Glucose Homeostasis in IUGR Fetuses
    Sean W Limesand; Fiscal Year: 2013
    ..and mortality, and potentially lower the incidence of adult onset diseases that have been correlated with low birth weight. PUBLIC HEALTH RELEVANCE: Fetal growth restriction continues to contribute to major medical problems for the ..
  61. Epidemiology of testicular cancer in the Utah population
    Mia Hashibe; Fiscal Year: 2012
    ..results across studies include lower birth order, higher maternalage, short gestational duration, and low birth weight. Thus far, an epidemiologic study on testicular cancer in Utah has never been conducted...
  62. Adiponectin regulates nutrient transport in the placenta
    Theresa L Powell; Fiscal Year: 2009
    ..proposal will provide preliminary data to address the mechanisms whereby maternal obesity leads to increased birth weight. Specifically, we will test the hypothesis that low blood concentrations of the hormone adiponectin in obese ..
  63. Fetal Programming and Human Physical Performance
    Tom Brutsaert; Fiscal Year: 2009
    ..e., low birth weight (BW) and low ponderal index, PI, kg/m3) and results in a permanent re-programming of metabolism which increases ..
  64. Comprehensive Clinical Decision Support for the Primary Care of Premature Infants
    Robert W Grundmeier; Fiscal Year: 2010
    ..is a rapidly growing public health concern in the United States, with over 60,000 infants born in 2006 with a birth weight under 1500 grams1...
  65. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2010
    ..brain damage, management of neonatal jaundice remains based upon proxies, such as gestational age and birth weight along with the bilirubin level. A number of methods for assaying the bilirubin level now ex- ist...
  66. Temperature & Vasomotor Tone During the First 5 Days in Preterms Less than 1000g
    ROBIN BRITT KNOBEL; Fiscal Year: 2010
    ..examine maturation of vasomotor tone by measuring central and peripheral body temperature of 30 extremely low birth weight (ELBW) infants in relationship to peripheral perfusion during the first 5 days of life...
  67. EEG synchrony of preterm infants: Regional disparities and perinatal risks
    Philip Grieve; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Despite advances in perinatal care over the past decades, extremely low birth weight (ELBW: birth weight <1000gm;age at birth ~ <30 wks) infants are at high risk for cerebral palsy (CP), ..
  68. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
    ..births, including 1400 who are admitted to the WFUSM neonatal intensive care units, and 270 who are very low birth weight. An important attribute of WFUSM is that it is a regional perinatal and neonatal center which provides care ..
  69. The Neonatal Microbiome and Necrotizing Enterocolitis
    Phillip Tarr; Fiscal Year: 2009
    ..About 80% of cases occur within 35 days of birth among hospitalized newborns of low birth weight. Probiotics diminish the incidence and severity of NEC, and NEC does not occur antepartum...
  70. Accelerating Adoption of Comparative Effectiveness Research in Premature Infants
    Phillip Brian Smith; Fiscal Year: 2010
    ..proposal will change prescribing and feeding practices and measure these practice changes in 25% of very low birth weight (<1500 g birth weight) infants born in the US...
  71. A Collaborative, Intersectional Approach to Health Disparities in Pregnancy
    Tina Bloom; Fiscal Year: 2007
    ..Serious health disparities in pregnancy outcomes (maternal and infant mortality, preterm birth, and low birth weight) exist, and in many cases, are growing worse...
  72. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..was conducted to examine the effect of antenatal vitamin A supplementation on vertical transmission of HIV, birth weight, and other health outcomes in Malawi...
  73. Early Identification of Developmental Disorders in Infants
    B Parker; Fiscal Year: 2007
    ..with in vitro fertilization procedures, the number of preterm (< 37 weeks postmenstrual age) very low birth weight (< 1,500 g) infants born is growing [2]...
  74. Multiple Chronic Conditions in VLBW Infants: Epidemiology, NICU Care, and Outcome
    William Gardner; Fiscal Year: 2010
    ..Premature and very low birth weight infants (PVLBW, defined as gestational age d 32 weeks and birth weight d 1500g) are 100 times more likely than ..
  75. Vitamin D status in pregnant women
    Theresa Scholl; Fiscal Year: 2009
    ..The prognostic importance of maternal vitamin D status for birth weight, gestation duration and poor pregnancy outcomes (low birth weight, preterm delivery, fetal growth restriction)...
  76. AMALGAM RESTORATIONS AND PREGNANCY OUTCOMES
    Richard Mitchell; Fiscal Year: 1993
    ..whether restorations increase the risk that a pregnancy will end with a spontaneous abortion, stillbirth, low birth weight infant, or congenital abnormality...
  77. Wed Based Outreach for Pregnant African American Women
    JoAnne Herman; Fiscal Year: 2001
    DESCRIPTION: Low birth weight and preterm birth are the primary factors responsible for neonatal deaths, perinatal deaths, and infants with permanent neurological damage...
  78. MORTALITY BY RACE AMONG LOW BIRTH WEIGHT INFANTS
    Robert Michielutte; Fiscal Year: 1990
    ..and behavioral factors, and characteristics of the mother and infant previously found to be related to low birth weight and infant mortality...
  79. KANGAROO MOTHER CARE TO PREVENT INFANT MORTALITY
    Nancy Sloan; Fiscal Year: 2001
    Low birth weight (LBW) puts infants at greater risk of life-threatening respiratory and gastrointestinal conditions that account for much of the mortality in early infancy...
  80. Assessment of Nicotine Metabolism Among Underserved Pregnant Women from NE SCRIPT
    Donna Parker; Fiscal Year: 2007
    ..The effect of tobacco exposure on the infant's birth weight may have long-term consequences...