sclerosis

Summary

Summary: A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.

Top Publications

  1. ncbi Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issues
    Chris Zarow
    University of Southern California, Rancho Los Amigos National Rehabilitation Center, 7601 E Imperial Highway, Medical Science Building, Room 26, Downey, CA 90242, USA
    Curr Neurol Neurosci Rep 8:363-70. 2008
  2. doi International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods
    Ingmar Blumcke
    Department of Neuropathology, University Hospital Erlangen, Erlangen, Germany
    Epilepsia 54:1315-29. 2013
  3. ncbi Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis
    Hideaki Hamano
    Second Department of Internal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621, Matsumoto, Japan
    Lancet 359:1403-4. 2002
  4. ncbi Treatment options for encapsulating peritoneal sclerosis based on progressive stage
    H Kawanishi
    Akane Foundation, Tsuchiya General Hospital, Hiroshima, Japan
    Adv Perit Dial 17:200-4. 2001
  5. ncbi ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis
    Heinz Gregor Wieser
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Epilepsia 45:695-714. 2004
  6. pmc Assessing the validity of an abdominal CT scoring system in the diagnosis of encapsulating peritoneal sclerosis
    Ruth M Tarzi
    Imperial College Kidney and Transplant Institute, Hammersmith Hospital, London, UK
    Clin J Am Soc Nephrol 3:1702-10. 2008
  7. pmc Encapsulating peritoneal sclerosis in the new millennium: a national cohort study
    Michaela C Brown
    Scottish Renal Registry, Royal Infirmary, Glasgow, UK
    Clin J Am Soc Nephrol 4:1222-9. 2009
  8. pmc Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy
    Osamu Yokota
    Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, UK
    Acta Neuropathol 120:55-66. 2010
  9. doi TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype
    Yvonne S Davidson
    Mental Health and Neurodegeneration Research Group, Salford Royal Foundation Trust, University of Manchester, Salford M6 8HD, UK
    Acta Neuropathol 122:703-13. 2011
  10. doi A cross-sectional MRI study of brain regional atrophy and clinical characteristics of temporal lobe epilepsy with hippocampal sclerosis
    Saud Alhusaini
    Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Epilepsy Res 99:156-66. 2012

Research Grants

  1. MERVYN N WEITZMANN; Fiscal Year: 2016
  2. Cory Teuscher; Fiscal Year: 2014
  3. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
  4. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
  5. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
  6. Neil W Kowall; Fiscal Year: 2014
  7. Michael Demetriou; Fiscal Year: 2014
  8. Shervin Assassi; Fiscal Year: 2014
  9. Samuel D Crish; Fiscal Year: 2016
  10. Inderjit Singh; Fiscal Year: 2014

Detail Information

Publications378 found, 100 shown here

  1. ncbi Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issues
    Chris Zarow
    University of Southern California, Rancho Los Amigos National Rehabilitation Center, 7601 E Imperial Highway, Medical Science Building, Room 26, Downey, CA 90242, USA
    Curr Neurol Neurosci Rep 8:363-70. 2008
    Hippocampal sclerosis (HS) is a pathologic term used to describe severe loss of neurons and reactive gliosis without cystic cavitation in the CA1 sector of the hippocampus...
  2. doi International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods
    Ingmar Blumcke
    Department of Neuropathology, University Hospital Erlangen, Erlangen, Germany
    Epilepsia 54:1315-29. 2013
    Hippocampal sclerosis (HS) is the most frequent histopathology encountered in patients with drug-resistant temporal lobe epilepsy (TLE)...
  3. ncbi Hydronephrosis associated with retroperitoneal fibrosis and sclerosing pancreatitis
    Hideaki Hamano
    Second Department of Internal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi, 390 8621, Matsumoto, Japan
    Lancet 359:1403-4. 2002
    ..Treatment with corticosteroids lowered serum concentrations of IgG4. IgG4 might also have a pathological role in a systemic fibrosing process that includes pancreatic and retroperitoneal lesions...
  4. ncbi Treatment options for encapsulating peritoneal sclerosis based on progressive stage
    H Kawanishi
    Akane Foundation, Tsuchiya General Hospital, Hiroshima, Japan
    Adv Perit Dial 17:200-4. 2001
    ..A more accurate description would be "encapsulating peritoneal sclerosis" (EPS). From the therapeutic perspective, the diagnosis should be established before EPS develops...
  5. ncbi ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis
    Heinz Gregor Wieser
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    Epilepsia 45:695-714. 2004
    ..and functional imaging findings, as well as surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS)...
  6. pmc Assessing the validity of an abdominal CT scoring system in the diagnosis of encapsulating peritoneal sclerosis
    Ruth M Tarzi
    Imperial College Kidney and Transplant Institute, Hammersmith Hospital, London, UK
    Clin J Am Soc Nephrol 3:1702-10. 2008
    Encapsulating peritoneal sclerosis (EPS) is a severe peritoneal fibrotic reaction in patients on long-term peritoneal dialysis (PD). The early clinical features may be nonspecific...
  7. pmc Encapsulating peritoneal sclerosis in the new millennium: a national cohort study
    Michaela C Brown
    Scottish Renal Registry, Royal Infirmary, Glasgow, UK
    Clin J Am Soc Nephrol 4:1222-9. 2009
    The study aim was to establish the incidence and characterize all encapsulating peritoneal sclerosis (EPS) cases in patients treated by peritoneal dialysis (PD).
  8. pmc Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy
    Osamu Yokota
    Greater Manchester Neurosciences Centre, Hope Hospital, University of Manchester, Salford, UK
    Acta Neuropathol 120:55-66. 2010
    ..Hippocampal sclerosis (HS) was found in 3/5 TDP-43-positive PSP cases, but HS was significantly more frequent in TDP-43-positive than ..
  9. doi TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype
    Yvonne S Davidson
    Mental Health and Neurodegeneration Research Group, Salford Royal Foundation Trust, University of Manchester, Salford M6 8HD, UK
    Acta Neuropathol 122:703-13. 2011
    ..onset after this age (LOAD)], 50 individuals with Down's Syndrome (DS) and 5 patients with primary hippocampal sclerosis (HS). TDP-43-ir pathological changes were present, overall, in 34/180 of AD cases...
  10. doi A cross-sectional MRI study of brain regional atrophy and clinical characteristics of temporal lobe epilepsy with hippocampal sclerosis
    Saud Alhusaini
    Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Epilepsy Res 99:156-66. 2012
    ..of extrahippocampal brain atrophy in a large sample of 'sporadic' mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE+HS)...
  11. pmc Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis
    Ross C McKiernan
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 7:e35921. 2012
    Hippocampal sclerosis (HS) is a common pathological finding in patients with temporal lobe epilepsy (TLE) and is associated with altered expression of genes controlling neuronal excitability, glial function, neuroinflammation and cell ..
  12. ncbi Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor)
    Satoshi Kitagawa
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Am J Surg Pathol 29:783-91. 2005
    ..The abundance of IgG4-positive plasma cells in the lesions would be useful for distinguishing CSS from other forms of sialadenitis...
  13. doi Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive: uncontrolled inflammation drives disease progression?
    Tianhua Yang
    Department of Neurology, West China Hospital, Si Chuan University, Cheng Du, Sichuan, China
    J Neurol Sci 296:1-6. 2010
    Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a group of chronic disorders characterized by prominent neuronal loss and gliosis in the hippocampus and amygdala...
  14. ncbi Histologic criteria for diagnosing encapsulating peritoneal sclerosis in continuous ambulatory peritoneal dialysis patients
    Kazuho Honda
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Adv Perit Dial 19:169-75. 2003
    To establish histologic criteria for a diagnosis of encapsulating peritoneal sclerosis (EPS), we investigated 69 peritoneal biopsy specimens histologically and immunohistochemically...
  15. doi Modulation of medial temporal lobe activity in epilepsy patients with hippocampal sclerosis during verbal working memory
    Pablo Campo
    Center of Magnetoencephalography Dr Perez Modrego, Complutense University of Madrid, Madrid 28040, Spain
    J Int Neuropsychol Soc 15:536-46. 2009
    ..MEG) to compare the patterns of MTL activation of 9 epilepsy patients suffering from left hippocampal sclerosis with those of 10 healthy matched controls while they performed a verbal WM task...
  16. pmc Remote effects of hippocampal sclerosis on effective connectivity during working memory encoding: a case of connectional diaschisis?
    Pablo Campo
    Department of Basic Psychology, Autonoma University of Madrid, 28049 Madrid, Spain
    Cereb Cortex 22:1225-36. 2012
    ..recordings during verbal WM encoding, in temporal lobe epilepsy patients (with left hippocampal sclerosis) and controls...
  17. pmc Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis
    T Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    Gut 52:683-7. 2003
    ..Autoimmune pancreatitis is a unique clinical entity proposed recently, and is sometimes associated with inflammation of other organs...
  18. ncbi Cellular pathology of hilar neurons in Ammon's horn sclerosis
    I Blumcke
    Department of Neuropathology, University of Bonn Medical Center, D 53105 Bonn, Germany
    J Comp Neurol 414:437-53. 1999
    ..The sclerotic hippocampus in Ammon's horn sclerosis (AHS)-associated MTLE, which shows segmental neuronal cell loss, axonal reorganization, and astrogliosis, would ..
  19. doi White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis
    L Concha
    Department of Biomedical Engineering, University of Alberta, Alberta, Canada
    J Neurol Neurosurg Psychiatry 80:312-9. 2009
    ..in the temporal and extratemporal white matter of patients with temporal-lobe epilepsy (TLE) and mesial temporal sclerosis (MTS) have previously been identified...
  20. doi Encapsulating peritoneal sclerosis: clinical significance and implications
    T Augustine
    Manchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, Manchester, UK
    Nephron Clin Pract 111:c149-54; discussion c154. 2009
    Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication of peritoneal dialysis (PD)...
  21. doi Temporal lobe epilepsy: neuropathological and clinical correlations in 243 surgically treated patients
    Laura Tassi
    Epilepsy Surgery Centre C Munari, Milan, Italy
    Epileptic Disord 11:281-92. 2009
    ..The frequency of different types of lesion and hippocampal sclerosis (HS), isolated or associated with neocortical lesions, risk factors and surgical outcomes in relation to ..
  22. doi Calbindin D28K expression in relation to granule cell dispersion, mossy fibre sprouting and memory impairment in hippocampal sclerosis: a surgical and post mortem series
    L Martinian
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Epilepsy Res 98:14-24. 2012
    ..gyrus, including granule cell dispersion (GCD) and mossy fibre sprouting, typically accompany hippocampal sclerosis (HS) in temporal lobe epilepsy...
  23. doi Brain plasticity for verbal and visual memories in patients with mesial temporal lobe epilepsy and hippocampal sclerosis: an fMRI study
    Andréa Alessio
    Neuroimaging Laboratory, School of Medical Sciences, University of Campinas, UNICAMP, Campinas, Brazil
    Hum Brain Mapp 34:186-99. 2013
    ..and patients with unilateral mesial temporal lobe epilepsy (MTLE) associated with unilateral hippocampal sclerosis (HS) by means of functional magnetic resonance imaging (fMRI)...
  24. pmc Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia
    Chun Zhang
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, 410 N 12th St, Richmond, VA 23298, USA
    Hypertension 60:154-62. 2012
    ..In conclusion, NALP3 inflammasome formation and activation on stimulation of homocysteine are important molecular mechanisms triggering podocyte injury and ultimately resulting in glomerulosclerosis in hHcys...
  25. pmc A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls
    Sébastien S Hébert
    Axe Neurosciences, Centre de Recherche du CHU de Québec, Quebec, QC, Canada
    J Alzheimers Dis 35:335-48. 2013
    ..gray matter from non-demented controls (n = 2), AD (n = 5), dementia with Lewy bodies (n = 4), hippocampal sclerosis of aging (n = 4), and frontotemporal lobar dementia (FTLD) (n = 5) cases, together accounting for the most ..
  26. ncbi Extrahippocampal temporal lobe atrophy in temporal lobe epilepsy and mesial temporal sclerosis
    N F Moran
    Epilepsy Research Group, University Department of Clinical Neurology, Institute of Neurology, University College London and The National Society for Epilepsy, Chalfont St Peter, Buckinghamshire, UK
    Brain 124:167-75. 2001
    Visual inspection and volumetric analysis of MRIs allow mesial temporal sclerosis (MTS) to be reliably identified in patients with temporal lobe epilepsy...
  27. ncbi Memory outcome after selective amygdalohippocampectomy: a study in 140 patients with temporal lobe epilepsy
    Ulrike Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 43:87-95. 2002
    ..The results of previous studies, however, are equivocal in this regard. This study evaluated memory after SAH in a large sample of patients with mesial temporal lobe epilepsy...
  28. doi Salivary duct carcinoma arising in IgG4-related autoimmune disease of the parotid gland
    Jespal Gill
    Diagnostic Medlab, Auckland, New Zealand
    Hum Pathol 40:881-6. 2009
    ..To the best of our knowledge, this case is the first documentation of malignancy occurring in a background of IgG4-related autoimmune disease of the salivary gland...
  29. doi IgG4-related sclerosing mastitis: description of a new member of the IgG4-related sclerosing diseases
    Wah Cheuk
    Department of Pathology, Queen Elizabeth Hospital, Wylie Road, Kowloon, Hong Kong
    Am J Surg Pathol 33:1058-64. 2009
    ..characterized by mass-forming lesions in various organs due to dense lymphoplasmacytic infiltrates and stromal sclerosis, elevated serum IgG4 titer, increased tissue IgG4 plasma cells, and favorable clinical outcome...
  30. doi Riedel's thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum
    Mollie Dahlgren
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arthritis Care Res (Hoboken) 62:1312-8. 2010
    ..IgG4-related systemic disease is characterized by IgG4+ plasma cell infiltration and fibrosis throughout many organs. We hypothesized that Riedel's thyroiditis is part of the IgG4-related systemic disease spectrum...
  31. doi Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis
    Ivanda de Souza Silva Tudesco
    Department of Psychobiology of Universidade Federal de São Paulo UNIFESP, Sao Paulo, Brazil
    Epilepsy Behav 18:223-8. 2010
    The aim of the present study was to investigate whether working memory is impaired in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), a controversial and largely unexplored matter.
  32. pmc Neural correlates of working memory in Temporal Lobe Epilepsy--an fMRI study
    J Stretton
    Epilepsy Society MRI Unit, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Neuroimage 60:1696-703. 2012
    ..We used a visuo-spatial 'n-back' paradigm to compare WM network activity in 38 unilateral hippocampal sclerosis (HS) patients (19 left) and 15 healthy controls...
  33. doi Regional neocortical thinning in mesial temporal lobe epilepsy
    Carrie R McDonald
    Department of Psychiatry, and Multimodal Imaging Laboratory, University of California, San Diego, CA 92093 0841, USA
    Epilepsia 49:794-803. 2008
    ..To determine the nature and extent of regional cortical thinning in patients with mesial temporal lobe epilepsy (MTLE)...
  34. ncbi MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome
    R P Carne
    Victorian Epilepsy Centre, St Vincent s Hospital, Victoria, Australia
    Brain 127:2276-85. 2004
    Most patients with non-lesional temporal lobe epilepsy (NLTLE) will have the findings of hippocampal sclerosis (HS) on a high resolution MRI...
  35. ncbi Encapsulating peritoneal sclerosis in Japan: a prospective, controlled, multicenter study
    Hideki Kawanishi
    Tsuchiya General Hospital, Hiroshima, Japan
    Am J Kidney Dis 44:729-37. 2004
    Encapsulating peritoneal sclerosis (EPS) is recognized as a rare but serious complication of peritoneal dialysis (PD). The aim of this study was to determine the incidence, clinical features, and mortality rate of EPS.
  36. pmc Reorganization of verbal and nonverbal memory in temporal lobe epilepsy due to unilateral hippocampal sclerosis
    H W Robert Powell
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
    Epilepsia 48:1512-25. 2007
    Patients with temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) often suffer from material-specific memory impairments...
  37. ncbi Magnetic resonance imaging evidence of hippocampal sclerosis in asymptomatic, first-degree relatives of patients with familial mesial temporal lobe epilepsy
    Eliane Kobayashi
    Department of Neurology, University of Campinas, Sao Paulo, Brazil
    Arch Neurol 59:1891-4. 2002
    To investigate the presence of hippocampal atrophy (HA) and other magnetic resonance imaging (MRI) signs of hippocampal sclerosis (HS) in asymptomatic relatives of patients with familial mesial temporal lobe epilepsy (FMTLE).
  38. doi The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis
    Gustavo Adolfo Arganãraz
    Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo, Brazil
    Epilepsia 49:1348-57. 2008
    ..was to localize and quantify AngII AT1 and AT2 receptors in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis (MTS) submitted to corticoamygdalohippocampectomy for seizure control.
  39. ncbi WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis
    Jian Kan Guo
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    Hum Mol Genet 11:651-9. 2002
    ..Mesangial sclerosis is one of the most consistent findings in Denys-Drash patients and can be caused by dominant mutations in the ..
  40. ncbi Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank
    Warren W Barker
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Alzheimer Dis Assoc Disord 16:203-12. 2002
    ..such as Lewy body disease (LBD), vascular dementia (VaD), frontotemporal dementia (FTD), and hippocampal sclerosis (HS). This ambiguity may be related to factors such as the age and gender of subjects with dementia...
  41. ncbi Pathology of encapsulating peritoneal sclerosis
    Kazuho Honda
    Department of Pathology, Tokyo Women s Medical University, Tokyo, Japan
    Perit Dial Int 25:S19-29. 2005
    Pathology findings of encapsulating peritoneal sclerosis (EPS) are reviewed to establish histologic criteria for a diagnosis of EPS. The typical macroscopic finding is a cocoon-like encapsulation of the entire intestine...
  42. doi Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: the importance of the "latent period" and other concepts
    Robert S Sloviter
    Department of Pharmacology, University of Arizona, College of Medicine, Tucson, Arizona 85724 5050, USA
    Epilepsia 49:85-92. 2008
    ..epilepticus in rats has long been promoted as an animal model of mesial temporal lobe epilepsy with hippocampal sclerosis, under the assumption that these animals involve: (1) pathology similar to that of the human neurologic ..
  43. ncbi Surgical techniques for prevention of recurrence after total enterolysis in encapsulating peritoneal sclerosis
    Hideki Kawanishi
    Tsuchiya General Hospital, Hiroshima, Japan
    Adv Perit Dial 24:51-5. 2008
    We performed total enterolysis in 130 patients with encapsulating peritoneal sclerosis (EPS) between 1993 and 2007. The postoperative survival rate was 93.1%. However, 33 of the patients (25...
  44. doi Hippocampal sclerosis--origins and imaging
    Kristina Malmgren
    Epilepsy Research Group, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Epilepsia 53:19-33. 2012
    The association between hippocampal sclerosis (HS) and epilepsy has been known for almost two centuries...
  45. doi An 18-year follow-up of seizure outcome after surgery for temporal lobe epilepsy and hippocampal sclerosis
    Marta Hemb
    Servico de Neurologia, Hospital São Lucas da PUCRS Av Ipiranga, 6690 220 90610 000, Porto Alegre, RS, Brazil
    J Neurol Neurosurg Psychiatry 84:800-5. 2013
    ..the very long-term clinical outcome of surgery for mesial temporal lobe epilepsy and unilateral hippocampal sclerosis (MTLE/HS) without atypical features...
  46. pmc Aortic sclerosis: not an innocent murmur but a marker of increased cardiovascular risk
    A K Nightingale
    Department of Cardiology, The Queen Elizabeth Hospital, The University of Adelaide, Adelaide, Australia
    Heart 91:1389-93. 2005
    ..The detection of an ejection systolic murmur in the aortic valve region often corresponds to a diagnosis of aortic sclerosis or minor disruption of the aortic valve with associated turbulence but minimal obstruction...
  47. ncbi Diffusion tensor imaging in medial temporal lobe epilepsy with hippocampal sclerosis
    Lionel Thivard
    Epileptology Unit, Hopital de la Salpetriere, 75013 Paris, France
    Neuroimage 28:682-90. 2005
    ..diffusion imaging studies in patients with medial temporal lobe epilepsy (MTLE) accompanied by hippocampal sclerosis (HS) have shown an increased diffusivity in the epileptogenic hippocampus...
  48. ncbi Losing neurons: selective vulnerability and mesial temporal sclerosis
    Darrell V Lewis
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Epilepsia 46:39-44. 2005
    Mesial temporal sclerosis (MTS) is found in about two-thirds of patients with refractory temporal lobe epilepsy (TLE), and surgical removal of the sclerotic structures eliminates seizures in the majority of cases undergoing surgical ..
  49. ncbi Encapsulating peritoneal sclerosis--a clinician's approach to diagnosis and medical treatment
    Hidetomo Nakamoto
    Department of Nephrology, Tokorozawa Kidney Clinic, Tokorozawa, Japan
    Perit Dial Int 25:S30-8. 2005
    Encapsulating peritoneal sclerosis (EPS) is recognized as a serious complication of continuous peritoneal dialysis...
  50. ncbi Successful surgical management of encapsulating peritoneal sclerosis
    Hideki Kawanishi
    Akane Foundation, Tsuchiya General Hospital, Hiroshima, Japan
    Perit Dial Int 25:S39-47. 2005
    Encapsulating peritoneal sclerosis (EPS) is a serious complication of long-term peritoneal dialysis (PD). The mortality rate for EPS has been high, primarily because of complications related to bowel obstruction...
  51. ncbi Peritoneal dialysis in Japan: the issue of encapsulating peritoneal sclerosis and future challenges
    Akira Saito
    Department of Molecular Nephrology and Bioartificial Organs, Institute of Medical Science, Tokai University, Kanagawa, Japan
    Perit Dial Int 25:S77-82. 2005
    Encapsulating peritoneal sclerosis (EPS) is a life-threatening complication of peritoneal dialysis (PD). The overall prevalence of EPS in Japanese PD patients is 2.3%. Among patients on PD for less than 5 years, the rate is 0...
  52. ncbi Four consecutive cases of peritoneal dialysis-related encapsulating peritoneal sclerosis treated successfully with tamoxifen
    Mohmed A Eltoum
    Wessex Renal and Transplantation Unit, Queen Alexandra Hospital, Portsmouth, Hampshire, United Kingdom
    Perit Dial Int 26:203-6. 2006
    Sclerosing peritonitis is a rare complication of peritoneal dialysis (PD). In encapsulating peritoneal sclerosis (EPS), the most severe form of the disease, the intestine is entrapped in a fibrous tissue, causing intestinal obstruction...
  53. doi Outcome predictors for surgical treatment of temporal lobe epilepsy with hippocampal sclerosis
    Susanne Aull-Watschinger
    Department of Neurology, Medical University of Vienna, Vienna, Austria
    Epilepsia 49:1308-16. 2008
    ..seizure control in patients with medically intractable temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS), diagnosed by magnetic resonance imaging (MRI), and ascertained histopathologically...
  54. ncbi [Application of amplitude of low-frequency fluctuation to the temporal lobe epilepsy with bilateral hippocampal sclerosis: an fMRI study]
    Zhi qiang Zhang
    Department of Medical Imaging, Clinical School, Medical College of Nanjing University Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China
    Zhonghua Yi Xue Za Zhi 88:1594-8. 2008
    ..the changes of amplitude of low-frequency fluctuation (ALFF) of the resting-fMRI in the mesial temporal lobe epilepsy (mTLE) with bilateral hippocampal sclerosis (HS), and discussed its underlying neuro-pathophysiological mechanism.
  55. pmc Involvement of the thalamocortical network in TLE with and without mesiotemporal sclerosis
    Susanne G Mueller
    Center for Imaging of Neurodegenerative Diseases, San Francisco, California, USA
    Epilepsia 51:1436-45. 2010
    ..This study investigated how structural abnormalities in the focus, ipsilateral thalamus and extrafocal cortical structures relate to each other in TLE with mesiotemporal sclerosis (TLE-MTS) and without hippocampal sclerosis (TLE-no).
  56. ncbi [Bladder neck sclerosis after surgical or transurethral resection of the prostate: a report of 40 cases]
    Sallami Sataa
    Service d Urologie, CHU La Rabta, Tunis, Tunisie
    Tunis Med 87:810-3. 2009
    ..To describe diagnostic and therapeutic particularity of complication through a sample of 40 patients...
  57. doi Imaging features of encapsulating peritoneal sclerosis in continuous ambulatory peritoneal dialysis patients
    Joanna P Ti
    Department of Radiology, Beaumont Hospital, Dublin, Ireland
    AJR Am J Roentgenol 195:W50-4. 2010
    The purpose of this article is to present the spectrum of radiologic findings of encapsulating peritoneal sclerosis in patients undergoing continuous ambulatory peritoneal dialysis (CAPD).
  58. pmc Testicular fusocellular rhabdomyosarcoma as a metastasis of elbow sclerosing rhabdomyosarcoma: A clinicopathologic, immunohistochemical and molecular study of one case
    Miguel Martorell
    Department of Pathology, Hospital General Universitario de Valencia, University of Valencia, Spain
    Diagn Pathol 5:52. 2010
    ..PCR chimeric transcriptional products PAX3-FKHR and PAX7-FKHR were not found. Six months following testicular resection, the patient died of multiple metastases in the mediastinum, lung and right thigh...
  59. doi Balloon cells in the dentate gyrus in hippocampal sclerosis associated with non-herpetic acute limbic encephalitis
    Hiroaki Miyahara
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Chuo Ku, Niigata 951 8585, Japan
    Seizure 20:87-9. 2011
    ..cells, a pathognomonic cellular feature of focal cortical dysplasia type IIB, in a background of hippocampal sclerosis is rare...
  60. pmc Bipolar plasma vaporization in secondary bladder neck sclerosis--initial experience with a new technique
    B Geavlete
    Department of Urology, Sf Ioan Clinical Emergency Hospital, Bucharest, Romania
    J Med Life 5:120-5. 2012
    Secondary bladder neck sclerosis (BNS) represents one of the most common long-term complications after prostate surgical treatment...
  61. pmc Sclerosing peritonitis: a rare but fatal complication of peritoneal inflammation
    Monika Merkle
    Medizinische Poliklinik, Campus Innenstadt, Klinikum der LMU, Pettenkoferstrasse 8a, 80336 Munchen, Germany
    Mediators Inflamm 2012:709673. 2012
    ..This article gives an overview of reasons and treatment options for sclerosing peritonitis and shows a summery of current literature about sclerosing peritonitis...
  62. doi Granule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis
    Rafael Scarpa da Costa Neves
    Department of Neurology, Neurosurgery, Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo, SP, Brazil
    Clin Neuropathol 32:24-30. 2013
    ..this retrospective study of a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS) was to analyze the association of granule cell dispersion (GCD) with surgical prognosis, patterns of MTS ..
  63. doi Investigation of hypoxia-inducible factor-1α in hippocampal sclerosis: a postmortem study
    Alexandra Feast
    Departments of Clinical and Experimental Epilepsy Neuropathology Neurology, UCL, Institute of Neurology, Queen Square, London, United Kingdom
    Epilepsia 53:1349-59. 2012
    ..We used a postmortem (PM) series from patients with epilepsy and hippocampal sclerosis (HS) to investigate patterns of expression of HIF-1α and VEGF and their potential contribution to ..
  64. pmc Immunoglobulin G4-related sclerosing disease involving the urethra: case report
    Jin Woo Choi
    Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul 110 744, Korea
    Korean J Radiol 13:803-7. 2012
    ....
  65. ncbi Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia
    K J Hatanpaa
    Department of Pathology, University of Texas Southwestern Medical School, Dallas 75390 9073, USA
    Neurology 63:538-42. 2004
    Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis...
  66. doi Relationship between hypometabolic patterns and ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: An FDG-PET study
    Eun Mi Lee
    Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, 388 1, Pungnap dong, Songpa Gu, Seoul 138 736, Republic of Korea
    Epilepsy Res 84:187-93. 2009
    ..explore the relationship between scalp ictal EEG patterns and interictal hypometabolic patterns in hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) and determine the clinical significance of interictal ..
  67. doi ApoE epsilon4 is not associated with posictal confusion in patients with mesial temporal lobe epilepsy with hippocampal sclerosis
    Marcelo Andrés Kauffman
    Centro de Epilepsia, Division Neurologia, Hospital Ramos Mejia, CEFYBO, CONICET, Buenos Aires, Argentina
    Epilepsy Res 85:311-3. 2009
    ..67; d.f.=1; p=0.2). Thus, the association between ApoE epsilon4 allele and postictal confusion still needs to be fully investigated in different and independent populations...
  68. ncbi Morphological aspects of peritoneal sclerosis
    G Garosi
    Nephrology and Dialysis Department, Le Scotte Hospital, Siena, Italy
    J Nephrol 14:S30-8. 2001
    The term peritoneal sclerosis simply means the presence of sclerotic tissue in the peritoneum...
  69. ncbi Mesial temporal lobe epilepsy and hippocampal sclerosis: cognitive function assessment in Hispanic patients
    Silvia Oddo
    Epilepsy Center, Neurology Division, Ramos Mejia Hospital, Av Scalabrini Ortiz 2330 1 degrees E, Capital Federal, CP 1425, Buenos Aires, Argentina
    Epilepsy Behav 4:717-22. 2003
    ..study was to assess the cognitive function status in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (TLE+HS) to determine their cognitive function profile and to correlate material-specific memory deficits with ..
  70. ncbi Bladder neck incision using a 70 W 2 micron continuous wave laser (RevoLix)
    Thorsten Bach
    Department of Urology, Asklepios Hospital Barmbek, Ruebenkamp 220, 22291, Hamburg, Germany
    World J Urol 25:263-7. 2007
    ..Two patients developed restenosis so far. Although longer follow-up and larger sample size are needed, BNI with the RevoLix laser is a fast, safe and promising procedure in recurrent bladder neck sclerosis.
  71. doi Memory outcome following transsylvian selective amygdalohippocampectomy in 62 patients with hippocampal sclerosis
    Michiharu Morino
    Departments of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan
    J Neurosurg 110:1164-9. 2009
    ..was performed to determine the effects of selective surgery on memory outcome in patients with intractable mesial temporal lobe epilepsy due to hippocampal sclerosis treated using transsylvian selective amygdalohippocampectomy (TSA).
  72. ncbi Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic study
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Surg Pathol 33:1330-40. 2009
    ..In addition, the evaluation of IgG4+ plasma cells and the ratio of IgG4+/IgG+ plasma cells and the presence of obstructive phlebitis may be useful for the differential diagnosis between IMT and IgG4-related sclerosing disease...
  73. doi Chronic sclerosing pyelitis with an increased number of IgG4-positive plasma cells
    Naoto Kuroda
    Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2 13 51 Shin honmachi, Kochi 780 8562, Japan
    Med Mol Morphol 42:236-8. 2009
    ..Finally, pathologists and clinicians should be aware of the possibility that the renal pelvis may be involved in IgG4-related systemic disease...
  74. ncbi Temporal lobe epilepsy due to hippocampal sclerosis in pediatric candidates for epilepsy surgery
    A Mohamed
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    Neurology 56:1643-9. 2001
    ..outcome in pediatric candidates for epilepsy surgery who have temporal lobe epilepsy (TLE) caused by hippocampal sclerosis (HS)...
  75. doi Primary gastrointestinal clear cell sarcoma: report of 2 cases, one case associated with IgG4-related sclerosing disease, and review of literature
    Mee Joo
    Department of Pathology, Inje University Ilsan Paik Hospital, Goyang, South Korea
    Ann Diagn Pathol 13:30-5. 2009
    ..Dense lymphoplasmacytic infiltration with extensive sclerosis and obliterative phlebitis was observed in the immediate vicinity of the primary and metastatic tumors, but not ..
  76. doi Diagnosis of Hashimoto's thyroiditis and IgG4-related sclerosing disease
    Kennichi Kakudo
    Department of Human Pathology, Wakayama Medical University, Wakayama, Japan
    Pathol Int 61:175-83. 2011
    ..Furthermore, the differences and close relationship between HT and Riedel's thyroiditis (RT), which was also demonstrated to be involved in IgG4-RSD spectrum, will be reviewed...
  77. pmc Hippocampal sclerosis in temporal lobe epilepsy: findings at 7 T¹
    Thomas R Henry
    Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    Radiology 261:199-209. 2011
    ..To determine if ultrahigh-field-strength magnetic resonance (MR) imaging can be used to detect subregional hippocampal alterations...
  78. ncbi Neuronal hypertrophy in the neocortex of patients with temporal lobe epilepsy
    S Bothwell
    Department of Zoology, Trinity College, University of Dublin, Dublin 2, Ireland
    J Neurosci 21:4789-800. 2001
    ..Studies were conducted on the neocortex of patients with or without hippocampal sclerosis (HS)...
  79. ncbi Increased expression of "peripheral-type" benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis
    Anny Sauvageau
    Neuroscience Research Unit, CHUM, Montreal, Quebec, Canada
    Metab Brain Dis 17:3-11. 2002
    ..This study was undertaken to assess PTBR expression in relation to the presence of hippocampal sclerosis in human temporal lobe epilepsy (TLE)...
  80. ncbi From swelling to sclerosis: acute change in mesial hippocampus after prolonged febrile seizure
    Deborah K Sokol
    Indiana University School of Medicine, Indianapolis, IN, USA
    Seizure 12:237-40. 2003
    Mesial temporal sclerosis (MTS) has been linked to prolonged febrile seizures. The sequence of changes in the temporal lobe/hippocampus following prolonged febrile seizures and status epilepticus is beginning to be elucidated...
  81. ncbi Lymphoplasmacytic sclerosing pancreatitis is a pancreatic lesion of IgG4-related systemic disease
    Terumi Kamisawa
    Am J Surg Pathol 28:1114. 2004
  82. ncbi Association between APOE polymorphisms and mesial temporal lobe epilepsy with hippocampal sclerosis
    S N Yeni
    Department of Neurology, Cerrahpasa Medical School, Istanbul University, Cerrahpasa, Istanbul, Turkey 34303
    Eur J Neurol 12:103-7. 2005
    ..link between apolipoprotein E (APOE) polymorphisms and mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) and whether presence of APOE epsilon4 allele shortens the latent period between febrile seizures and ..
  83. pmc Clinical characteristics of dialysis related sclerosing encapsulating peritonitis: multi-center experience in Korea
    Beom Seok Kim
    Division of Nephrology, Department of Internal Medicine, Institute of Kidney Disease, Yonsei University College of Medicine, 134 Shinchon dong, Seodaemun gu, Seoul 120 752, Korea
    Yonsei Med J 46:104-11. 2005
    ..Therefore, to reduce the incidence of SEP, careful monitoring and treatment, including early catheter removal in patients with severe peritonitis, should be considered for long-term CAPD patients with the above characteristics...
  84. ncbi The pathogenesis and therapeutic option of encapsulating peritoneal sclerosis
    H Kawanishi
    Tsuchiya General Hospital, 3 30 Nakajima cho, Naka ku, Hiroshima 730 8655, Japan
    Int J Artif Organs 28:150-5. 2005
    Since the first peritoneal dialysis (PD) patients with encapsulating peritoneal sclerosis (EPS) were reported in 1980, EPS has been considered primarily a fatal complication...
  85. ncbi MRI evidence of mesial temporal sclerosis in sporadic "benign" temporal lobe epilepsy
    A Labate
    Institute of Neurology, University Magna Graecia, Catanzaro, Italy
    Neurology 66:562-5. 2006
    To determine whether there is MRI-detectable mesial temporal sclerosis (MTS) in patients with sporadic benign temporal lobe epilepsy (BTLE).
  86. doi Idiopathic sclerosing peritonitis
    Yashwant Koak
    Department of General Surgery, Basildon Hospital, Nethermayes, Basildon, London, UK
    Eur J Gastroenterol Hepatol 20:148-50. 2008
    ..The patient continues to have chronic intestinal failure, managed conservatively by long-term parenteral nutrition and steroids for more than 12 years...
  87. ncbi Intestinal obstruction due to idiopathic sclerosing encapsulating peritonitis. Clinical report and review of literature
    V Minutolo
    Dipartimento Scienze Chirurgiche, Trapianti d Organo, Universita degli Studi di Catania
    G Chir 29:173-6. 2008
    ..In this report we describe surgical treatment, pathologic pattern and clinical findings of this rare disease...
  88. pmc Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent
    Taiji Matsusaka
    Departments of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Hypertension 55:967-73. 2010
    ..08+/-2.41 in knockout versus 4.84+/-0.73 in control). Both strains of mice showed similar degrees of sclerosis (0.66+/-0.17 versus 0.82+/-0.27 on a 0 to 4 scale) and downregulation of nephrin (5.78+/-0.45 versus 5.65+/-0...
  89. doi Enhanced fibrillin-2 expression is a general feature of wound healing and sclerosis: potential alteration of cell attachment and storage of TGF-beta
    Jurgen Brinckmann
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Lab Invest 90:739-52. 2010
    Wound healing and sclerosis are characterized by an increase of extracellular matrix proteins, which are characteristically expressed in the embryo-fetal period...
  90. doi Osteopathia striata with cranial sclerosis owing to WTX gene defect
    Bram Perdu
    Department of Medical Genetics, University and University Hospital of Antwerp, 2610 Antwerp, Belgium
    J Bone Miner Res 25:82-90. 2010
    Osteopathia striata with cranial sclerosis (OSCS) is an X-linked dominant condition marked by linear striations mainly affecting the metaphyseal region of the long bones and pelvis in combination with cranial sclerosis...
  91. pmc Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study
    Maria Thom
    Department of Clinical and Experimental Epilepsy, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 134:2969-81. 2011
    ..01) and high Braak stage (P < 0.001). Hippocampal sclerosis, identified in 40% (bilateral in 48%), was not associated with higher Braak stages, but asymmetrical patterns of ..
  92. ncbi Aortic valve sclerosis is associated with systemic endothelial dysfunction
    Elisa Poggianti
    Echocardiography Laboratory, Institute of Clinical Physiology, CNR, Pisa, Italy
    J Am Coll Cardiol 41:136-41. 2003
    We sought to examine the association between aortic valve sclerosis (AVS) and systemic endothelial manifestations of the atherosclerotic process.
  93. ncbi Morphologic changes of peritoneum and expression of VEGF in encapsulated peritoneal sclerosis rat models
    Hiroaki Io
    Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan
    Kidney Int 65:1927-36. 2004
    Simple sclerosis consisted of a thin layer of submesothelial sclerotic tissue in peritoneal dialysis patients...
  94. ncbi IgG4-related sclerosing disease
    Terumi Kamisawa
    Intern Med 45:125-6. 2006
  95. pmc Bilateral reorganization of the dentate gyrus in hippocampal sclerosis: a postmortem study
    M Thom
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, Queen Square, London, UK
    Neurology 73:1033-40. 2009
    Hippocampal sclerosis (HS) is the most common surgical pathology associated with mesial temporal lobe epilepsy (MTLE)...
  96. doi Reliability of patterns of hippocampal sclerosis as predictors of postsurgical outcome
    Maria Thom
    Divisions of Neuropathology and Neurology, Department of Clinical and Experimental Epilepsy, University College London, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, U K
    Epilepsia 51:1801-8. 2010
    ..undergoing temporal lobe surgery for the treatment of intractable temporal lobe epilepsy with hippocampal sclerosis (HS) fail to become seizure-free...
  97. ncbi Febrile convulsions and mesial temporal sclerosis
    D V Lewis
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Opin Neurol 12:197-201. 1999
    Patients with intractable temporal lobe epilepsy and mesial temporal sclerosis often have histories of severe febrile convulsions as infants...
  98. ncbi Peritoneal sclerosis: one or two nosological entities?
    G Garosi
    Nephrology and Dialysis Department, Le Scotte Hospital, Siena, Italy
    Semin Dial 13:297-308. 2000
    ..animal models, pathogenesis, clinical manifestations, diagnostic criteria, therapy and prevention of peritoneal sclerosis are reviewed...
  99. ncbi Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts
    Tracy L McGaha
    Department of Microbiology, The Mount Sinai School of Medicine, New York, New York 10029, USA
    J Invest Dermatol 118:461-70. 2002
    ..Our results demonstrate that halofuginone is a specific inhibitor of type-I collagen synthesis and may elicit its effect via interference with the transforming growth factor beta signaling pathway...
  100. ncbi Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study
    James B Leverenz
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
    Arch Neurol 59:1099-106. 2002
    Hippocampal sclerosis (HS) is a neuropathologic finding characterized by neuronal loss and gliosis in the CA-1 and subiculum of the hippocampus...
  101. ncbi Glucocorticoid protects against the development of encapsulating peritoneal sclerosis on peritoneal dialysis
    Hiroe Imai
    Department of Nephrology, Saitama Medical School, Saitama, Japan
    Adv Perit Dial 18:124-30. 2002
    Encapsulating peritoneal sclerosis (EPS) is an important complication of peritoneal dialysis in which all or part of the intestine is enveloped in a fibrous ball resulting in a cocoon...

Research Grants74

  1. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..including Crohn's disease, psoriasis and psoriatic arthritis, systemic lupus erythematosus;multiple sclerosis;Type I Diabetes, and as anti-rejection agents following solid organ and bone marrow transplantation...
  2. Cory Teuscher; Fiscal Year: 2014
    ..diseases such as experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis (MS)...
  3. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ..to) traumatic brain injury (TBI), damage during tumor resection, stroke, inflammatory diseases (such as multiple sclerosis), chemicals (including medications and alcohol), degeneration due to genetic errors, other degenerative ..
  4. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Systemic sclerosis (SSc;scleroderma) is a complex multisystem autoimmune disease of unknown cause associated with early transient inflammation and vascular injury followed by progressive fibrosis ..
  5. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..system by disease, as occurs in various myasthenic disorders, spinal muscular atrophy, and amyotrophic lateral sclerosis, toxins such as botulinum toxin, or traumatic injury, results in muscle weakness and even death...
  6. Neil W Kowall; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by progressive paralysis due to motor neuron degeneration...
  7. Michael Demetriou; Fiscal Year: 2014
    ..interacts with an allele of CTLA-4 that reduces N-glycan number by ~50%, increasing the risk of Multiple Sclerosis (MS) and Rheumatoid Arthritis (RA) by ~2 fold...
  8. Shervin Assassi; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Title: Molecular Markers for Progression of Pulmonary Fibrosis in Systemic Sclerosis Candidate: Dr...
  9. Samuel D Crish; Fiscal Year: 2016
    ..In other neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease, early pathologies occur in first in the axon - and this has been recently ..
  10. Inderjit Singh; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Multiple sclerosis (MS) is central nervous system (CNS) inflammatory, demyelinating disease that affects individuals in their most productive ages...
  11. Judith A James; Fiscal Year: 2016
    ..Multiple sclerosis, rheumatoid arthritis, pediatric arthritis, insulin-dependent diabetes, idiopathic thrombocytopenia and ..
  12. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..recently has been shown to be a broad based anti-inflammatory agent effective in animal models of multiple sclerosis, rheumatoid arthritis, ischemia-reperfusion injury, and stroke...
  13. Mitzi Nagarkatti; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Multiple sclerosis (MS) is a neurodegenerative autoimmune disease that affects approximately one million people worldwide. There are over 28,000 veterans currently diagnosed with MS...
  14. SAMY LEWIZ HABIB; Fiscal Year: 2016
    ..One of the tumor suppressor genes involved in renal carcinogenesis is tuberous sclerosis gene (TSC2), which encodes tumor suppressor protein, tuberin...
  15. BONE MATRIX AND BONE RESORPTION
    Paul R Odgren; Fiscal Year: 2012
    ..also recently discovered a dominant point mutation (R714C) in PLEKHM1 in a patient with low bone mass and focal sclerosis which we propose is a gain-of- function mutation...
  16. Petr Tvrdik; Fiscal Year: 2014
    ..and progression of neurological disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis, as well as obsessive compulsive disorder and schizophrenia...
  17. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..and inflammation in other disease states such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, inflammatory bowel disease, kidney disease, rheumatoid arthritis and chronic obstructive pulmonary disease, ..
  18. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type I diabetes mellitus (DM) and multiple sclerosis (MS)...
  19. Brian F Volkman; Fiscal Year: 2016
    ..SDF1 monomers and dimers to alter disease progression in animal models for human diseases including multiple sclerosis, ulcerative colitis, and metastatic cancer...
  20. Autoimmunity Center of Excellence (ACE) at Stanford
    CHARLES GARRISON FATHMAN; Fiscal Year: 2013
    ..Proposed clinical research projects encompass three different autoimmune diseases [diffuse systemic sclerosis (SSc), psoriatic arthritis and systemic juvenile idiopathic arthritis (SJIA)] that afflict adults and children, ..
  21. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013
    ..More recent evidence shows that mutations in FUS/TLS are found in familial cases of amyotrophic lateral sclerosis (ALS)...
  22. Complex I: Role of L Subunit in Proton Translocation
    Steven B Vik; Fiscal Year: 2011
    ..the protein subunits of Complex I are risk factors for a wide range of diseases and disorders, such as multiple sclerosis, Type 2 diabetes, and bipolar disorder...
  23. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..Furthermore these cytokines have been implicated in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis...
  24. Identification of Compounds to treat Charcot-Marie-Tooth type 2E neuropathy
    RONALD K LIEM; Fiscal Year: 2010
    ..in patients with mutations in NEFL, as well as in other neurodegenerative diseases, such as amyotrophic lateral sclerosis. We have shown that the mutant NFL proteins form aggregates in transfected neuronal and non-neuronal cells...
  25. Robert W Burgess; Fiscal Year: 2016
    ..in humans, create directly relevant animal models for preclinical testing of therapies, and identify new therapeutic targets for these diseases, and possibly other motor neuron diseases such as Amyotrophic Lateral Sclerosis (ALS).
  26. Jingsong Zhou; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disorder involving degeneration of motor neurons and atrophy of skeletal muscle...
  27. Role of Potent Trophic Factors on Glia and Motor Neurons in ALS
    Brian K Kaspar; Fiscal Year: 2013
    Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease, which results in muscle paralysis and ultimate respiratory failure and death. The underlying cause for ALS remains unknown with no cure...
  28. Christin Carter-Su; Fiscal Year: 2016
    ..growth and metabolism, and other SH2B1 activating ligands contribute to, prevent and/or alleviate symptoms of a variety of diseases including obesity, various cancers, diabetes, multiple sclerosis, and diseases of the immune system.
  29. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
    ..of some of the ILDs are known, including those associated with connective tissue diseases such as systemic sclerosis (SSc, or scleroderma)...
  30. Sienmi Du; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Most autoimmune diseases affect more females than males. Multiple sclerosis (MS) is a putative autoimmune demyelinating disease of the central nervous system (CNS) characterized in the initial stages ..
  31. Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
    MELISSA ANN BROWN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multiple sclerosis (MS), the most common inflammatory disease of the central nervous system (CNS), affects more than 2.5 million people worldwide...
  32. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Scleroderma (also known as systemic sclerosis-SSc) is an autoimmune disorder characterized primarily by progressive dermal and vascular fibrosis...
  33. The voltage-gated Kv1.3 channel in psoriatic disease: A novel therapeutic target
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..for TEM cell mediated autoimmune diseases by demonstrating that autoreactive T cells from patients with multiple sclerosis, type-1 diabetes and rheumatoid arthritis are predominantly Kv1.3high TEM cells and that Kv1...
  34. Chromatin Modifications and Vulnerability to Glutamate Toxicity
    ALEXEI D KONDRATYEV; Fiscal Year: 2010
    ..conditions, such as Alzheimer's, Huntington's, and Parkinson's diseases, amyotrophic lateral sclerosis, ataxia telangiectasia and many other neurological disorders...
  35. Role of Dendritic Ca2+ Transients in Respiratory Rhythm Generation
    Jack L Feldman; Fiscal Year: 2010
    ..neurodegenerative diseases, such as Parkinson's disease, multiple systems atrophy and amyotrophic lateral sclerosis, are associated with sleep disordered breathing that we hypothesize results from the loss of neurons in brain ..
  36. Enhance Production of Functional Recombinant Human Protein C Variant In Mammalian
    Nienwen Chow; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Amyotrophic lateral sclerosis (ALS) is a motor neuron disorder characterized by the degeneration and death of motor neurons. Currently there is no cure for ALS. Most ALS cases are sporadic...
  37. Kim Wallen; Fiscal Year: 2014
    ..motivation, hot flushes, sleep disorders, depression/anxiety, brain and spinal cord trauma, amyotrophic lateral sclerosis, and cognitive dysfunction...
  38. David E Cohen; Fiscal Year: 2016
    ..composition that limits insulin signaling by binding thioesterase superfamily member 2 (Them2) and tuberous sclerosis complex 2 (TSC2)...
  39. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..disorders including, but not limited to, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (Lou Gherig's disease), dystonia, spinocerebellar ataxias and Rett's Syndrome...
  40. TNF Family Members and Control of Fibrotic Disease
    Michael Croft; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Human systemic sclerosis (SSc) is an autoimmune-like disease that results in excessive production of collagen in the skin as well as tissues such as kidney, heart, and lung...
  41. Testing the efficacy of PGC-1alpha as a therapeutic target for Parkinson's diseas
    HANS BUELER; Fiscal Year: 2010
    ..diseases that are caused by mitochondrial dysfunction and oxidative stress, such as PD and amyotrophic lateral sclerosis. Here we propose to test the hypothesis that boosting mitochondrial biogenesis and function through recombinant ..
  42. Scott R Barnum; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Amyotrophic Lateral Sclerosis (ALS) is a progressive motor neuron disease that leads to degeneration of motor neurons in the cortex, brainstem and spinal cord resulting in progressive paralysis and ..
  43. Jianxiong Jiang; Fiscal Year: 2014
    ..chronic neurodegenerative disorders involving neuroinflammation with EP2 activation, including stroke, multiple sclerosis and Alzheimer's disease...
  44. Mitzi Nagarkatti; Fiscal Year: 2015
    ..Multiple Sclerosis (MS) is one such autoimmune disease that affects ~350,000-500,000 people in the US...
  45. TIMOTHY TUN HLA; Fiscal Year: 2016
    ..generation S1P receptor modulator called FTY720 is currently undergoing clinical trials (phase III) for multiple sclerosis and transplant rejection, the findings from this research program may provide critical information that is ..
  46. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    ..of pathologies involving elevated extracellular glutamate levels, such as epilepsy and amyotrophic lateral sclerosis (ALS)...
  47. Glutathione in mitochondrial dysfunction and disease progression in ALS-models
    Marcelo R Vargas; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Amyotrophic lateral sclerosis (ALS) or Lou Gehrig's disease is characterized by the specific death of the nerve cells that control muscle ..
  48. Immune Regulation of Viral Recrudescence
    Cornelia Bergmann; Fiscal Year: 2012
    ..in humans during infections associated with neurological complications and the demyelinating disease multiple sclerosis (MS)...
  49. K-Channels in Lymphocyte Function and Autoimmunity
    GEORGE KANIANTHARA CHANDY; Fiscal Year: 2012
    ..Disease-associated autoreactive T cells in patients with multiple sclerosis (MS), type-1 diabetes mellitus (T1DM) and rheumatoid arthritis (RA) are TEM cells with elevated expression of ..
  50. SEAN JOSEPH PITTOCK; Fiscal Year: 2014
    ..Neuromyelitis optica (NMO;aka optic spinal multiple sclerosis [MS]) is a devastating disease that disproportionally affects non-Caucasians...
  51. Autoimmunity Center of Excellence - Rochester
    R John Looney; Fiscal Year: 2013
    ..we will target include systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, multiple sclerosis, and type I diabetes mellitus...
  52. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..RELEVANCE: Selective motor injury occurs in a number of neurodegenerative diseases such as Primary Lateral Sclerosis, pure Hereditary Spastic Paraplegia, Kennedy's disease, Spinal Muscular Atrophy, Progressive Muscular ..
  53. Paul M Lieberman; Fiscal Year: 2015
    ..Additional diseases may also be associated with KSHV, including autoimmune disorders like multiple sclerosis and system lupus erythematosis...
  54. Endothelial-reactive antibodies: a diagnostic test for Susac's syndrome
    WILLIAM JAMES WALDMAN; Fiscal Year: 2011
    ..callosum, lesions commonly detected by MRI in other regions of the brain may lead to misdiagnosis as multiple sclerosis (MS)...
  55. In vivo analysis of the mechanisms of axon transport.
    Catherine M Drerup; Fiscal Year: 2011
    ..neurodevelopmental and neurodegenerative disorders, including Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Charcot-Marie Tooth Disease...
  56. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
    ..g. the Guam amyotrophic lateral sclerosis, konzo, and/or lathyrism) suggests that environmental factors e.g...
  57. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..a combination of pulmonary inflammation and fibrosis - remains the main cause of death in patients with systemic sclerosis, or scleroderma...
  58. Jin Billy Li; Fiscal Year: 2016
    ..Aberrant RNA editing has been implicated in human neurological diseases such as amyotrophic lateral sclerosis, epilepsy, depression, suicide, glioma, and cancers, and may have contributed to the evolutionary development of ..
  59. RNA polymerase II Elongation Complex: Structure and Function
    Daniel Reines; Fiscal Year: 2013
    ..results in the neurodegenerative diseases Ataxia and Ocular Apraxia (AOA) type 2 and Amyotrophic Lateral Sclerosis (ALS) type 4...
  60. Onanong Chivatakarn; Fiscal Year: 2014
    ..responses, and are profoundly affected by diseases such as spinal muscle atrophy (SMA) and amyotrophic lateral sclerosis (ALS)...
  61. Ralph A Nixon; Fiscal Year: 2014
    ..in neurofibrillary diseases, including Alzheimer's disease and related dementias, amyotrophic lateral sclerosis and related neuronopathies, Parkinson's disease and glaucoma...
  62. ALS therapies and genomics for mutant TDP-43 and TLS/FUS
    Don W Cleveland; Fiscal Year: 2010
    ..Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder in which premature loss of upper and lower motor neurons ..
  63. Kenneth J Gustafson; Fiscal Year: 2014
    ..after neurological injury or disorders such as spinal cord injury (SCI), brainstem stroke, and multiple sclerosis can have a devastating impact on patients and their families, resulting in a high cost to the individual and to ..
  64. Long Acting Beta Interferon for Treating Multiple Sclerosis - Phase II Continuing
    George Cox; Fiscal Year: 2009
    ..beta interferon products have annual worldwide sales of $4 billion, primarily from their use to treat Multiple Sclerosis. Beta interferon has a short half-life in humans, which necessitates frequent dosing and may not optimize ..
  65. Arginase and Regulation of Nitric Oxide Synthase in ALS
    Rajiv Ratan; Fiscal Year: 2004
    DESCRIPTION (Adapted from applicant's abstract): Amyotrophic lateral sclerosis is a prevalent neurological disorder characterized by inexorable muscle weakness leading to death...
  66. MYELIN BASIC PROTEIN PEPTIDES IN BODY FLUIDS
    JOHN WHITAKER; Fiscal Year: 1993
    ..from damaged central nervous system myelin enter cerebrospinal fluid, blood and urine of persons with multiple sclerosis and that measurement of these peptides offers a means of monitoring of tissue injury...
  67. Role of p62 in Protein Aggregation and Neurodegeneration in ALS
    Haining Zhu; Fiscal Year: 2009
    ..containing mutant copper-zinc superoxide dismutase (SOD1) are a hallmark of familial amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), an age-related neurodegenerative disease...
  68. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2005
    Multiple sclerosis (MS) is a clinical neurological disease characterized by chronic inflammation, demyelination and gliosis of the central nervous system...
  69. MULTIPLE-SCLEROSIS: A CD40 LIGAND ANTAGONIST
    Lloyd Kasper; Fiscal Year: 2003
    Multiple sclerosis (MS) is a clinical neurological disease characterized by chronic inflammation, demyelination and gliosis of the central nervous system...
  70. T Cells in the Pathogenesis of Systemic Sclerosis
    Chris Platsoucas; Fiscal Year: 2005
    Systemic Sclerosis (SSc) is a chronic disease characterized by extensive fibrosis, microvascular fibrointimal proliferation and autoantibody production. T cells and monocytes infiltrate early skin lesions of patients with SSc...
  71. Development of a T cell specific multiple sclerosis drug
    Arthur Vandenbark; Fiscal Year: 2005
    The broad, long-term objective of this project is to develop a new class of drugs for treatment of multiple sclerosis (MS)...