Genomes and Genes
Summary: Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.
Publications265 found, 100 shown here
- Motor axon excitability during Wallerian degenerationMihai Moldovan
Division of Neurophysiology, Institute of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
Brain 132:511-23. 2009..Following loss of axonal continuity, the isolated nerve stump distal to the lesion undergoes Wallerian degeneration in several phases...
- Wallerian degeneration, wld(s), and nmnatMichael P Coleman
Laboratory of Molecular Signaling, The Babraham Institute, Cambridge CB223AT, United Kingdom
Annu Rev Neurosci 33:245-67. 2010..Here, we review the cellular and molecular events that underlie this process, termed Wallerian degeneration. We describe the biphasic nature of axon degeneration after axotomy and our current understanding of how ..
- A longitudinal diffusion tensor imaging study on Wallerian degeneration of corticospinal tract after motor pathway strokeChunshui Yu
Department of Radiology, Xuanwu Hospital, Capital Medical University, No 45, Chang Chun Street, Xuanwu District, Beijing 100053, PR China
Neuroimage 47:451-8. 2009b>Wallerian degeneration of the corticospinal tract (CST) after motor pathway ischemic stroke can be characterized by diffusion tensor imaging (DTI)...
- Water diffusion changes in Wallerian degeneration and their dependence on white matter architectureC Pierpaoli
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-5772, USA
Neuroimage 13:1174-85. 2001This study investigates water diffusion changes in Wallerian degeneration. We measured indices derived from the diffusion tensor (DT) and T2-weighted signal intensities in the descending motor pathways of patients with small chronic ..
- Why is Wallerian degeneration in the CNS so slow?Mauricio E Vargas
Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
Annu Rev Neurosci 30:153-79. 2007b>Wallerian degeneration (WD) is the set of molecular and cellular events by which degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the PNS but slow and incomplete in the CNS is a longstanding mystery...
- Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain inductionPetr Dubovy
Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, Czech Republic
Ann Anat 193:267-75. 2011b>Wallerian degeneration is a cascade of stereotypical events in reaction to injury of nerve fibres...
- Axon degeneration mechanisms: commonality amid diversityMichael Coleman
The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
Nat Rev Neurosci 6:889-98. 2005..dysfunction and an increase in intra-axonal calcium - have been identified by rescuing axons with the slow Wallerian degeneration gene (Wld(S)) and studies with blockers of sodium or calcium influx...
- Mice lacking complex gangliosides develop Wallerian degeneration and myelination defectsK A Sheikh
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 96:7532-7. 1999..Yamamoto, A., Furukawa, K., Yamashiro, S., Shin, M., Okada, M., Fukumoto, S., Haraguchi, M., Takeda, N., Fujimura, K., et al. (1996) Proc. Natl. Acad. Sci. USA 93, 10662-10667]...
- Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imagingShu Wei Sun
Department of Radiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Neuroimage 40:1-10. 2008b>Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases...
- A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrityYanshan Fang
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Curr Biol 22:590-5. 2012..Together, these findings demonstrate an essential role of endogenous Nmnat in maintaining axonal integrity that may rely on and function by stabilizing mitochondria...
- Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degenerationToshiyuki Araki
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Science 305:1010-3. 2004..In Wallerian degeneration slow (wlds) mice, Wallerian degeneration in response to axonal injury is delayed because of a mutation ..
- ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylationShuji Wakatsuki
Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
Nat Cell Biol 13:1415-23. 2011b>Wallerian degeneration is observed in many neurological disorders, and it is therefore important to elucidate the axonal degeneration mechanism to prevent, and further develop treatment for, such diseases...
- Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activityR Grace Zhai
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America
PLoS Biol 4:e416. 2006b>Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury...
- Wallerian degeneration: a major component of early axonal pathology in multiple sclerosisTomasz Dziedzic
Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
Brain Pathol 20:976-85. 2010..However, the contribution of Wallerian degeneration to axonal pathology is not known...
- The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degenerationGerd Meyer zu Horste
Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
Neurobiol Dis 42:1-8. 2011..Clinical impairments are determined by the amount of axonal loss. Axons of the spontaneous mouse mutant Wallerian degeneration slow (Wlds) show markedly reduced degeneration following various types of injuries...
- Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degenerationLaura Conforti
The Babraham Institute, Cambridge, UK
FEBS J 278:2666-79. 2011..However, the role of endogenous NMNAT1 in normal axon maintenance and in Wallerian degeneration has not been elucidated yet. To address this question we disrupted the Nmnat1 locus by gene targeting...
- Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degenerationNaoki Yahata
Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
J Neurosci 29:6276-84. 2009Studies of naturally occurring mutant mice, wld(s), showing delayed Wallerian degeneration phenotype, suggest that axonal degeneration is an active process...
- A local mechanism mediates NAD-dependent protection of axon degenerationJing Wang
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 170:349-55. 2005..of axon degeneration arose from findings that the degeneration of transected axons is delayed in Wallerian degeneration slow (Wlds) mice with the overexpression of a fusion protein with the nicotinamide adenine dinucleotide (..
- TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerveVeronica I Shubayev
San Diego VA Healthcare System, CA 92161, USA
Mol Cell Neurosci 31:407-15. 2006..In mice with delayed Wallerian degeneration (WldS), MMP-9 and tumor necrosis factor alpha (TNFalpha) decline in association with the reduced ..
- Interactions between Schwann cells and macrophages in injury and inherited demyelinating diseaseRudolf Martini
Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strabetae 11, Wuerzburg, Germany
Glia 56:1566-77. 2008..first discuss the factors that regulate macrophage recruitment, activation, and myelin phagocytosis during Wallerian degeneration and some of the factors involved in the termination of inflammation at the end of the period of Wallerian ..
- Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injuryAndrew D Gaudet
Department of Neuroscience and Center for Brain and Spinal Cord Repair, College of Medicine, The Ohio State University, 770 Biomedical Research Tower, 460 West 12th Ave, Columbus, OH 43210, USA
J Neuroinflammation 8:110. 2011..Future research will help determine how to manipulate PNS and CNS inflammatory responses in order to improve tissue repair and functional recovery...
- LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth diseaseChristian Somandin
Department of Biology, Institute of Molecular Health Sciences, Cell Biology, Swiss Federal Institute of Technology, ETH Zurich, CH 8093 Zurich, Switzerland
Glia 60:1518-28. 2012..In injured nerves, however, we found that lack of Litaf led to increased numbers of macrophages during Wallerian degeneration, accelerated myelin destruction, and the emergence of more axonal sprouts...
- Extrinsic cellular and molecular mediators of peripheral axonal regenerationFrank Bosse
Molecular Neurobiology Laboratory, Department of Neurology, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
Cell Tissue Res 349:5-14. 2012..During this fine-tuned process, named Wallerian degeneration, a remodeling of the distal nerve fragment prepares a permissive microenvironment that permits successful ..
- WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ bufferingMichelle A Avery
Department of Neurobiology, University of Massachusetts Medical School, and Howard Hughes Medical Institute, Worcester, MA 01605 2324, USA
Curr Biol 22:596-600. 2012Wld(S) (slow Wallerian degeneration) is a remarkable protein that can suppress Wallerian degeneration of axons and synapses, but how it exerts this effect remains unclear...
- Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspasesJ T Finn
Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
J Neurosci 20:1333-41. 2000..We focus on two models of selective axon degeneration: Wallerian degeneration of transected axons and localized axon degeneration induced by local deprivation of neurotrophin...
- A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degenerationBradley R Miller
Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, USA
Nat Neurosci 12:387-9. 2009..This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program...
- Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degenerationS L Carroll
Division of Neuropathology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 17:1642-59. 1997..In later stages of Wallerian degeneration, however, Schwann cell mitogenesis markedly decreases, whereas elevated GGF expression persists...
- WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicityJo Ann V Antenor-Dorsey
Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
Mol Neurodegener 7:5. 2012The WldS mouse mutant ("Wallerian degeneration-slow") delays axonal degeneration in a variety of disorders including in vivo models of Parkinson's disease...
- Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomyJiangyang Zhang
Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 29:3160-71. 2009..These data suggest that there is an early imaging signature associated with axon transections that could be used in a variety of neurological disease processes...
- Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degenerationKarine Palin
CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
Neurobiol Dis 30:19-29. 2008..We show that Wallerian degeneration of the mouse optic nerve induces transcription of TGF-beta1 and TNF-alpha, but not pro-inflammatory ..
- Mechanisms of axonal spheroid formation in central nervous system Wallerian degenerationBogdan Beirowski
Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom
J Neuropathol Exp Neurol 69:455-72. 2010b>Wallerian degeneration of the CNS is accompanied by axonal dystrophy or swelling...
- Spatiotemporal quantification of tumor necrosis factor-alpha and interleukin-10 after crush injury in rat sciatic nerve utilizing immunohistochemistryTomokazu Sawada
Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
Neurosci Lett 417:55-60. 2007..changes of the tumor necrosis factor-alpha (TNF) and interleukin-10 (IL-10) immunopositive cells during Wallerian degeneration and the following regeneration after crush injury in rat sciatic nerve using immunohistochemistry and ..
- Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivoBogdan Beirowski
Laboratory of Molecular Signalling, The Babraham Institute, Cambridge, UK
J Neurosci 29:653-68. 2009..The Wallerian degeneration slow (Wld(S)) protein protects axons dose-dependently in many circumstances but is paradoxically abundant ..
- Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degenerationFlorence E Perrin
Centre for Research in Neuroscience, McGill University Health Center, Montreal, Quebec, Canada
Brain 128:854-66. 2005b>Wallerian degeneration in the CNS and PNS consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury...
- When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI studyM Di Paola
Laboratory of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
Neurology 74:1136-42. 2010The corpus callosum (CC) has been shown to be susceptible to atrophy in Alzheimer disease (AD) as a correlate of wallerian degeneration or retrogenesis. However, when and where these 2 mechanisms intervene is still unclear.
- The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy miceWeiqian Mi
ZMMK and Institute for Genetics, University of Cologne, Cologne, Germany
Brain 128:405-16. 2005..The slow Wallerian degeneration gene, Wld(S), delays Wallerian degeneration after injury, and also delays 'dying-back' in peripheral ..
- Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous systemMohamed H Farah
Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 31:5744-54. 2011..These observations were reproduced in part by pharmacological inhibition of BACE1. These data suggest BACE1 inhibition as a therapeutic approach to accelerate regeneration and recovery after peripheral nerve damage...
- Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric geneT G Mack
Center for Molecular Medicine ZMMK and Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50674 Cologne, Germany
Nat Neurosci 4:1199-206. 2001Axons and their synapses distal to an injury undergo rapid Wallerian degeneration, but axons in the C57BL/WldS mouse are protected. The degenerative and protective mechanisms are unknown...
- Degeneration and regeneration of the peripheral nervous system: from Augustus Waller's observations to neuroinflammationGuido Stoll
Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
J Peripher Nerv Syst 7:13-27. 2002..by a reprint of Augustus Waller's 1850 article, which gave rise to the pathologic process termed Wallerian degeneration. This review is focused on the role of neuroinflammation in Wallerian degeneration and how immune ..
- Compartmental neurodegeneration and synaptic plasticity in the Wld(s) mutant mouseT H Gillingwater
Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, UK
J Physiol 534:627-39. 2001..Studies of the spontaneous mutant Wld(s) mouse, in which Wallerian degeneration is characteristically slow, provide key evidence in support of this hypothesis...
- Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degenerationKazuho Hirata
Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Microsc Res Tech 57:541-7. 2002The literature concerning Schwann cells (SCs) and macrophages in myelin phagocytosis during Wallerian degeneration is reviewed...
- Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivoStefan Milde
Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom
Sci Rep 3:2567. 2013..Overexpression of fluorescently tagged Nmnat2 significantly delays Wallerian degeneration in these mice...
- Axon retraction and degeneration in development and diseaseLiqun Luo
Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, CA 94305, USA
Annu Rev Neurosci 28:127-56. 2005..Here we review examples of these phenomena and consider potential cellular and molecular mechanisms that underlie axon retraction and degeneration and how they might relate to each other in development and disease...
- WldS mice are resistant to paclitaxel (taxol) neuropathyMin Sheng Wang
Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
Ann Neurol 52:442-7. 2002..strain that demonstrates the remarkable phenotype of prolonged survival of transected axons ("slow Wallerian degeneration")...
- Axonal self-destruction and neurodegenerationMartin C Raff
MRC Laboratory for Molecular Cell Biology and Cell Biology Unit and the Biology Department, University College London, London WC1E 6BT, UK
Science 296:868-71. 2002..Do neurons also use this second program to prune their axonal tree during development and to conserve resources in response to chronic insults?..
- Wallerian degeneration in the corticospinal tract evaluated by diffusion tensor imaging correlates with motor deficit 30 days after middle cerebral artery ischemic strokeJosep Puig
Department of Radiology, Girona Biomedical Research Institute, Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain
AJNR Am J Neuroradiol 31:1324-30. 2010..We evaluated the anisotropy by using DTI and signal-intensity changes on conventional MR imaging in the CST to determine whether these findings are correlated with limb motor deficit in patients with MCA ischemic stroke...
- Involvement of the ubiquitin-proteasome system in the early stages of wallerian degenerationQiwei Zhai
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuron 39:217-25. 2003..In this study, we used the degeneration of transected axons, termed "Wallerian degeneration," as a model to examine the possible involvement of the ubiquitin proteasome system (UPS)...
- Directional diffusion in relapsing-remitting multiple sclerosis: a possible in vivo signature of Wallerian degenerationRoland G Henry
Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143 1290, USA
J Magn Reson Imaging 18:420-6. 2003..To examine the role of directional dependence of the apparent diffusion coefficients in the evaluation of normal-appearing brain regions of patients with relapsing-remitting multiple sclerosis...
- Toll-like receptors in peripheral nerve injury and neuropathic painDongHoon Kim
Program in Molecular and Cellular Neuroscience, DRI, BK21, Department of Oral Physiology, School of Dentistry, Seoul National University, Seoul, Republic of Korea
Curr Top Microbiol Immunol 336:169-86. 2009..genetically modified mice indicate that Toll-like receptors (TLRs) are involved in nerve degeneration (Wallerian degeneration) and chronic pain (neuropathic pain) development after nerve injury...
- Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in DrosophilaXiao Liang Zhao
Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Neurosci 30:1512-22. 2010..These results suggest that Abeta accumulation depletes presynaptic and axonal mitochondria, leading to other presynaptic deficits...
- Macrophages are eliminated from the injured peripheral nerve via local apoptosis and circulation to regional lymph nodes and the spleenT Kuhlmann
Department of Neuropathology, , Campus Virchow-Klinikum, 13353 Berlin, Germany
J Neurosci 21:3401-8. 2001The present study investigated the fate of macrophages in peripheral nerves undergoing Wallerian degeneration, especially their disappearance from the injured nerves after phagocytosis of axonal and myelin debris...
- Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: implication in Wallerian degenerationHyunkyoung Lee
Program in Neuroscience, DRI, and Department of Oral Physiology, School of Dentistry, Seoul National University, 28 YeonGun Dong, Jongno gu, Seoul 110 749, Republic of Korea
Biochem Biophys Res Commun 350:742-7. 2006..In summary, these results suggest that necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3, which might be involved in Wallerian degeneration upon peripheral nerve injury.
- Wallerian degeneration after spinal cord lesions in cats detected with diffusion tensor imagingJ Cohen-Adad
GRSNC, Department of Physiology, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada
Neuroimage 57:1068-76. 2011..This decrease was specific to the type of fibers, i.e., rostrally to the lesion on the dorsal aspect of the cord and caudally to the lesion ipsilaterally, suggesting the detection of Wallerian degeneration.
- Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondriaBrandon M Kitay
Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA
Hum Mol Genet 22:1601-14. 2013..and recent reports suggest a central role for axonal mitochondria in both degeneration and NMNAT/WLD(S) (Wallerian degeneration slow)-mediated protection...
- The acute phase of Wallerian degeneration: longitudinal diffusion tensor imaging of the fornix following temporal lobe surgeryMin Liu
Department of Biomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Neuroimage 74:128-39. 2013Numerous animal studies have shown the applicability of diffusion tensor imaging (DTI) to track Wallerian degeneration that occurs after injury to the neural fiber...
- Local production of serum amyloid a is implicated in the induction of macrophage chemoattractants in Schwann cells during wallerian degeneration of peripheral nervesSo Young Jang
Department of Physiology, Mitochondria Hub Regulation Center, College of Medicine, Dong A University, Busan, South Korea
Glia 60:1619-28. 2012..Inflammatory cytokines in the peripheral nerves have been implicated in the Wallerian degeneration of peripheral nerves after injury and in certain types of inflammatory neuropathies...
- Pre-wallerian degeneration in the neonatal brain following perinatal cerebral hypoxia-ischemia demonstrated with MRIFloris Groenendaal
Department of Neonatology, Division of Perinatology and Gynecology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
Semin Perinatol 30:146-50. 2006Pre-Wallerian degeneration was studied in term and near-term neonates with hypoxic-ischemic brain injury, and related to neurodevelopmental outcome.
- Secretion of ATP from Schwann cells through lysosomal exocytosis during Wallerian degenerationYoun Ho Shin
Department of Anatomy, College of Medicine, Kyung Hee University, Heogi Dong 1, Dongdaemun Gu, Seoul 130 701, Republic of Korea
Biochem Biophys Res Commun 429:163-7. 2012..that adenosine triphosphate (ATP) is released from Schwann cells through lysosomal exocytosis during Wallerian degeneration and in response to stimulation. In primary Schwann cell cultures, ATP was stored in lysosomal vesicles...
- Extracellular ATP inhibits Schwann cell dedifferentiation and proliferation in an ex vivo model of Wallerian degenerationYoun Ho Shin
Department of Anatomy, College of Medicine, Kyung Hee University, Heogi Dong 1, Dongdaemun Gu, Seoul 130 701, Republic of Korea
Biochem Biophys Res Commun 430:852-7. 2013..we investigated the role of extracellular ATP in Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Using several markers of Schwann cell dedifferentiation and proliferation in sciatic explants, we found ..
- Toll-like receptor expression in the peripheral nerveSofie Goethals
Peripheral Neuropathy Group, Department of Molecular Genetics, VIB and University of Antwerp, Universiteitsplein 1, B 2610 Antwerpen, Belgium
Glia 58:1701-9. 2010..Furthermore, acute neurodegeneration induces a shift in TLR expression pattern, most likely illustrating specialized functions of TLRs in basal versus activated conditions of the peripheral nerve...
- Imaging corticospinal degeneration in neonatal rats with unilateral cerebral infarctionS Lama
Medical Science, Faculty of Medicine, University of Calgary
Exp Neurol 228:192-9. 2011..This demonstrates directly the utility of ADC and T(2) MRI to detect acute changes in axons associated with early Wallerian degeneration.
- Biology and pathology of nonmyelinating Schwann cellsJohn W Griffin
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Glia 56:1518-31. 2008..Nonmyelin-forming Schwann cells, including those associated with uninjured fibers, have the capacity to act as the "first responders" to injury or disease in their neighborhoods...
- Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivoElisabetta Babetto
The Babraham Institute, Laboratory of Molecular Signalling, Cambridge CB22 3AT, UK
J Neurosci 30:13291-304. 2010..The chimeric Wallerian degeneration slow protein (Wld(S)) protects axons dose dependently, but its mechanism is still elusive...
- Wallerian degeneration of the pontocerebellar fibersTiziana De Simone
Department of Neuroradiology, Istituto Nazionale Neurologico C Besta, Milan, Italy
AJNR Am J Neuroradiol 26:1062-5. 2005Two cases of pontine infarct with Wallerian degeneration (WD) of the pontocerebellar fibers are described...
- Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degenerationGerburg Keilhoff
Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Exp Neurol 212:189-200. 2008..The negative effect of minocycline on Wallerian degeneration, the essential initial phase of degeneration/regeneration after nerve injury, that was recently ..
- Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruningSeanna M Martin
Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
Development 137:3985-94. 2010..of injured axons that detach from their cell body break down by the molecularly regulated process of Wallerian degeneration (WD)...
- Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cordA Buss
Department of Neurology, Aachen University Medical School, Georg August Universitat Gottingen, Germany
Brain 128:356-64. 2005Axons undergo Wallerian degeneration (WD) distal to a point of injury. In the lesioned PNS, WD may be followed by successful axonal regeneration and functional recovery...
- Glial and axonal responses in areas of Wallerian degeneration of the corticospinal and dorsal ascending tracts after spinal cord dorsal funiculotomyLi Wang
Department of Neurobiology, Shanghai Jiaotong University School of Medicine, Shanghai, China
Neuropathology 29:230-41. 2009b>Wallerian degeneration (WD), composed of the breakdown and phagocytosis of damaged axons and their myelin sheaths distal to the injury, is a major sequela of spinal cord injury (SCI)...
- Genetic influences on cellular reactions to CNS injury: the reactive response of astrocytes in denervated neuropil regions in mice carrying a mutation (Wld(S)) that causes delayed Wallerian degenerationO Steward
Department of Neuroscience, University of Virginia Health Sciences Center, Charlottesville 22908, USA
J Comp Neurol 380:70-81. 1997..denervated neuropil regions in normal mice and in mice carrying the Wld(S) mutation which leads to delayed Wallerian degeneration. In situ hybridization and immunocytochemical techniques were used to define the time course of changes in ..
- A conditioning lesion protects axons from degeneration via the Wallenda/DLK MAP kinase signaling cascadeXin Xiong
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
J Neurosci 32:610-5. 2012..2010), and overexpression studies indicate that increased Wnd function is sufficient to promote protection from degeneration, we propose that Wnd regulates an adaptive response to injury that allows neurons to cope with axonal stress...
- The chemokine receptor CCR2 is involved in macrophage recruitment to the injured peripheral nervous systemH Siebert
Department of Neuropathology, Charite, Humboldt University, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
J Neuroimmunol 110:177-85. 2000b>Wallerian degeneration is one of the most elementary reactions of the nervous system after transection of axons, leading to the recruitment of mononuclear cells from the systemic circulation...
- The role of TNF-alpha during Wallerian degenerationM Liefner
Department of Neuropathology, Georg August Universitat, Gottingen, Germany
J Neuroimmunol 108:147-52. 2000The role of TNF-alpha in the course of Wallerian degeneration of the sciatic nerve was studied in control and TNF-alpha deficient mice...
- Involvement of placental growth factor in Wallerian degenerationLinda Chaballe
GIGA Neurosciences, Axonal Regeneration and Cephalic Pain unit, University of Liege, Avenue de l Hopital, Liege, Belgium
Glia 59:379-96. 2011b>Wallerian degeneration (WD) is an inflammatory process of nerve degeneration, which occurs more rapidly in the peripheral nervous system compared with the central nervous system, resulting, respectively in successful and aborted axon ..
- Molecular inflammatory mediators in peripheral nerve degeneration and regenerationCarlos Rodrigo Cámara-Lemarroy
Department of Physiology, Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Mexico
Neuroimmunomodulation 17:314-24. 2010b>Wallerian degeneration, the self-destructive set of cellular and molecular processes by which degenerating axons and myelin are cleared after injury, is initiated by macrophages and Schwann cells...
- Erythropoietin reduces Schwann cell TNF-alpha, Wallerian degeneration and pain-related behaviors after peripheral nerve injuryW Marie Campana
Department of Anesthesiology, University of California, San Diego School of Medicine, La Jolla, CA, USA
Eur J Neurosci 23:617-26. 2006Chronic sciatic nerve constriction injury (CCI) induces Wallerian degeneration and exaggerated pain-like behaviors. These effects are mediated in large part by pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha)...
- Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potentialCaroline Sievers
Center for Molecular Medicine ZMMK and Institute for Genetics, University of Cologne, Germany
Neurosci Res 46:161-9. 2003b>Wallerian degeneration, the disintegration of the distal part of an injured axon, is an important event in many neurodegenerative diseases...
- The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nervesBogdan Beirowski
Center for Molecular Medicine Cologne CMMC and Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50647 Cologne, Germany
BMC Neurosci 6:6. 2005The progressive nature of Wallerian degeneration has long been controversial...
- Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylationK Suzuki
Molecular Neurobiology Laboratory, Division of Life Science, Graduate School of Life Science, Hokkaido University, North Ward N10 W8, Sapporo 060 0810, Japan
Neuroscience 147:599-612. 2007It has been shown that Wallerian degeneration, an anterograde degeneration of transected axons, is markedly delayed in a mutant mouse called slow Wallerian degeneration (Wld(S))...
- Very early activation of m-calpain in peripheral nerve during Wallerian degenerationJonathan D Glass
Department of Neurology, Emory University School of Medicine, 1639 Pierce Drive, Suite 6000, Atlanta, GA 30322, USA
J Neurol Sci 196:9-20. 2002..Peripheral nerve injury results in a series of events culminating in degradation of the axonal cytoskeleton (Wallerian degeneration)...
- Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cellsA Saada
Department of Anatomy and Embryology, Hebrew University Hadassah Medical School, Jerusalem, Israel
J Cell Biol 133:159-67. 1996Peripheral nerve injury is followed by Wallerian degeneration which is characterized by cellular and molecular events that turn the degenerating nerve into a tissue that supports nerve regeneration...
- Glial cell responses, complement, and clusterin in the central nervous system following dorsal root transectionL Liu
Department of Anatomy, Biomedical Center, Uppsala University, Sweden
Glia 23:221-38. 1998..cascade, including the putative complement inhibitor clusterin, and their cellular association during Wallerian degeneration in the central nervous system...
- Delayed wallerian degeneration in sciatic nerves of C57BL/Ola mice is associated with impaired regeneration of sensory axonsM A Bisby
Department of Physiology, Queen s University, Kingston, Ontario, Canada
Brain Res 530:117-20. 1990b>Wallerian degeneration is delayed following sciatic nerve crush in C57BL/Ola mice. Compared to C57BL/6J mice, regeneration of sensory axons is significantly slowed in the Ola mice, but reinnervation does eventually occur...
- Hereditary absence of complement C5 in adult mice influences Wallerian degeneration, but not retrograde responses, following injury to peripheral nerveL Liu
Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
J Peripher Nerv Syst 4:123-33. 1999..These findings elucidate new aspects on the functional role of the complement system in the peripheral nervous system following peripheral nerve injury...
- Delayed glial cell death following wallerian degeneration in white matter tracts after spinal cord dorsal column cordotomy in adult ratsP Warden
Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, Missouri 63104, USA
Exp Neurol 168:213-24. 2001..the secondary injury processes occurring after SCI, we investigated the relationship between apoptosis and Wallerian degeneration in spinal white matter tracts...
- The role of macrophages in Wallerian degenerationW Bruck
Department of Neuropathology, University of Gottingen, Germany
Brain Pathol 7:741-52. 1997The present review focuses on macrophage properties in Wallerian degeneration. The identification of hematogenous phagocytes, the involvement of cell surface receptors and soluble factors, the state of activation during myelin removal and ..
- Corticospinal tract pre-wallerian degeneration: a novel outcome predictor for pediatric stroke on acute MRITrish Domi
Children s Stroke Program, The Hospital for Sick Children and Institute for Medical Science, University of Toronto, Toronto, ON, Canada
Stroke 40:780-7. 2009In neonatal arterial ischemic stroke, pre-Wallerian degeneration in descending corticospinal tracts (DCST) on diffusion MRI (DWI) predicts poor outcome. This signal has not been studied in older children.
- Focal Wallerian degeneration of the corpus callosum in large middle cerebral artery stroke: serial diffusion tensor imagingRakesh K Gupta
Department of Radiodiagnosis, King George s Medical University, Lucknow, India
J Magn Reson Imaging 24:549-55. 2006To detect lesion-related focal Wallerian degeneration (WD) changes in different segments of the corpus callosum (CC) in patients with large middle cerebral arterial (MCA) territory stroke using diffusion tensor imaging (DTI).
- Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependentR Wagner
Department of Anesthesiology at the Veterans Administration Medical Center and the University of California San Diego, La Jolla 92093 0629, USA
Pain 77:173-9. 1998..Experimental inflammatory compression injury to the sciatic nerve (chronic constriction injury, CCI) induces Wallerian degeneration of axons and damages non-neuronal cells at the injury site in association with the development of ..
- Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytesMiri Gitik
Dept of Medical Neurobiology, IMRIC, Hebrew University Hadassah Medical School, P O B 12272, Jerusalem 91120, Israel
J Neuroinflammation 8:24. 2011..produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops...
- Nature of signals that initiate the immune response during Wallerian degeneration of peripheral nervesS Karanth
Department of Neurosurgery, Centre for Neuroscience, Barts and The London, Queen Marys School of Medicine, University of London, The Royal London Hospital, London E1 1BB, UK
Exp Neurol 202:161-6. 2006Monocyte chemoattractant protein-1 is produced by Schwann cells during Wallerian degeneration of a peripheral nerve and contributes to a selective accumulation of macrophages in the degenerating segment...
- Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imagingMartin Bendszus
Department of Neuroradiology, University of Wurzburg, D 97080 Wurzburg, Germany
J Neurosci 23:10892-6. 2003..SPIO-enhanced MRI provides a new tool to selectively visualize active periods of macrophage transmigration into the nervous system, thus enabling dynamic views on a fundamental process in a multitude of nerve disorders...
- Wallerian degeneration after crush injury of rat sciatic nerve increases endo- and epineurial tumor necrosis factor-alpha proteinAnnette George
Neurologische Klinik der Universität Würzburg, Wurzburg, Germany
Neurosci Lett 372:215-9. 2004..IHC revealed prominent TNF-immunoreactivity in many epineurial macrophages on days 0.5 to 3 after crush injury. These data indicate that TNF protein is early and transiently upregulated at the site of peripheral nerve trauma...
- Calpain-mediated cleavage of collapsin response mediator protein(CRMP)-2 during neurite degeneration in miceEkatherina Touma
Molecular Neurobiology Laboratory, Graduate School of Life Science, Hokkaido University, Sapporo 060 0810, Japan
Eur J Neurosci 26:3368-81. 2007..No cleavage of CRMP-2 or -4 occurred in NGF-deprived neurites from Wld(s) (Wallerian degeneration slow) mutant mice in which neurite degeneration is markedly delayed...
- A Wallerian degeneration pattern in patients at risk for MSJ H Simon
Neuroradiology MRI Department, University of Colorado Health Sciences Center, Denver 80262, USA
Neurology 54:1155-60. 2000..In theory, axonal injury may occur in the focal areas characterized by early inflammation, or can be more distant, as in Wallerian degeneration. However, Wallerian degeneration is thought of as a rare or a late finding in MS.
- Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injuryAudrey Boivin
Laboratory of Molecular Endocrinology, CHUL Research Center, and Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada G1V 4G2
J Neurosci 27:12565-76. 2007..Here, we investigated whether TLRs are involved in regulating the immune response, Wallerian degeneration (WD), and nerve regeneration after sciatic nerve lesion...
- Wallerian degeneration: the innate-immune response to traumatic nerve injuryShlomo Rotshenker
Dept of Medical Neurobiology, IMRIC, Hebrew University, Faculty of Medicine, Jerusalem, Israel
J Neuroinflammation 8:109. 2011..Recovery by regeneration depends on the cellular and molecular events of Wallerian degeneration that injury induces distal to the lesion site, the domain through which severed axons regenerate back to ..
- Acute corticospinal tract Wallerian degeneration is associated with stroke outcomeGiselle DeVetten
Seaman Family MR Research Centre, Foothills Medical Centre, Alberta Health Services, Alberta, Canada
Stroke 41:751-6. 2010In children with stroke, poor motor outcome is associated with early Wallerian degeneration of the corticospinal tract that is seen on diffusion-weighted MRI...
- Canadian Association of Neuroscience review: axonal regeneration in the peripheral and central nervous systems--current issues and advancesKeith Fenrich
Centre for Neuroscience, Division of Physical Medicine and Rehabilitation, University of Alberta, Edmonton, AB, Canada
Can J Neurol Sci 31:142-56. 2004..Strategies to overcome these limitations in the PNS are considered in detail and contrasted with strategies in the CNS...
- NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degenerationL Conforti
The Babraham Institute, Cambridge CB2 4AT, UK
Cell Death Differ 14:116-27. 2007The slow Wallerian degeneration protein (Wld(S)), a fusion protein incorporating full-length nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1), delays axon degeneration caused by injury, toxins and genetic mutation...
- All roads lead to disconnection?--Traumatic axonal injury revisitedA Buki
Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
Acta Neurochir (Wien) 148:181-93; discussion 193-4. 2006..The anterograde and retrograde consequences of TAI are also considered together with a discussion of various experimental therapeutic approaches capable of attenuating TAI...
- Gradual loss of myelin and formation of an astrocytic scar during Wallerian degeneration in the human spinal cordA Buss
Department of Neurology, Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
Brain 127:34-44. 2004Axons undergo Wallerian degeneration distal to a point of injury. Experimental investigations have documented many of the cellular and molecular events that underlie this behaviour...
- A zebrafish model for neural regenerationALLISON F ROSENBERG; Fiscal Year: 2012..Immediately after nerve injury, an active process of axonal degeneration, termed Wallerian degeneration, ensues...
- Diabetes suppresses sympathetic neurotransmission and thereby glucagon secretionGerald J Taborsky; Fiscal Year: 2013..To prevent hyperglycemia-induced suppression of sympathetic ganglionic neurotransmission, we will use the Wallerian Degeneration Slow (Wlds) rat which our new Preliminary Data show to be resistant to this form of neural dysfunction...
- Neuronal events and molecular pathways in active dendrite degenerationMelissa Rolls; Fiscal Year: 2010..that this injury elicits an active degeneration program similar to axon degeneration after transection (Wallerian degeneration): distal dendrites are completely disassembled within 24 hours, and this disassembly is blocked by ..
- Inflammation and delayed cognitive dysfunction after strokeKRISTIAN PAUL DOYLE; Fiscal Year: 2013..We hypothesize that this inflammatory response is in response to Wallerian degeneration of the axons that project from the stroke lesion...
- Molecular Mechanisms of Axon DegenerationMarc R Freeman; Fiscal Year: 2013..Studies of axon degeneration after axotomy (i.e. Wallerian degeneration) have proven an extremely useful approach to elucidate fundamental cellular events driving axon auto-..
- The role of Sirt1 in Huntington's Disease.Dimitri Krainc; Fiscal Year: 2013..SIRT1 protects from Wallerian degeneration and protects against neurodegeneration in models of Alzheimer's disease, Amyotrophic lateral ..
- Mechanisms of Neuronal Maintenance and Protection.Rong Grace Zhai; Fiscal Year: 2013..enzyme, and the neuroprotective function of NMNAT has also been implicated in a mouse model of slow Wallerian Degeneration. Currently, the detailed mechanisms of this maintenance function and the protective capability of NMNAT in ..
- Understanding neuronal and axonal degeneration in a murine model of human MSShu Wei Sun; Fiscal Year: 2013..Prolonged injury can induce Wallerian degeneration, a process of neuronal apoptosis, resulting in damage that propagates along axons and leads to the cell ..
- A novel bioengineered technique to rapidly and permanently repair cut PNS nervesGEORGE DAVIS BITTNER; Fiscal Year: 2013..We retard Wallerian degeneration by cooling or cyclosporin A and then repair axons chronically severed for up 10 days by PEG-fusion...
- Spinal Cord-to-Computer InterfaceMesut Sahin; Fiscal Year: 2013..The distal portions of the severed motor axons go through Wallerian degeneration. However, the proximal part of the axon continues to function years after injury since its connection to ..
- Synaptic damage in models of beta-amyloid associated pathologyEdward H Koo; Fiscal Year: 2011..The third Aim will examine the phenotype of APP transgenic mice crossed to the WLDs (slow Wallerian degeneration) mutant mice...
- NEURONAL DEVELOPMENT INTERACTION AND ORGANIZATIONMichael Bennett; Fiscal Year: 2000..The role of these connexins in normal development and Wallerian degeneration following nerve lesions will be investigated using wild type and connexin knockout mice...
- Signal Transduction in Myelinating CellsCharles Stiles; Fiscal Year: 2006..unreadable] [unreadable] A favored biological context to address signaling in myelinated axons is the Wallerian degeneration response of rodent sciatic nerve...
- CELL DEATH IN THE OLIGODENDROGLIAL LINEAGEJudith Grinspan; Fiscal Year: 1999..Cell death also has been detected in several dysmyelinating mutations in rodents and following Wallerian degeneration of the optic nerve...
- Diffusion Tensor Imaging of Wallerian Degeneration in MSKhader Hasan; Fiscal Year: 2009..may include inflammation, demyelination, gliosis, direct axonal loss directly or indirectly through Wallerian degeneration (WD)...
- Connexins in Nerve Regeneration and Inherited NeuropathyCharles Abrams; Fiscal Year: 2009..its expression levels are regulated by GGF (which is thought to induce Schwann cell proliferation during Wallerian degeneration);and 3) loss of Cx32 mediated cell-cell channels leads to increased Schwann cell death...
- AXONAL TRANSPORT AND PERIPHERAL NERVE FUNCTIONKimberly Topp; Fiscal Year: 2001..Interruption of axonal transport leads to Wallerian degeneration of axons distal to the site of impairment...
- ROLE OF CD44 IN PERIPHERAL NERVE DEVELOPMENT AND INJURYLarry Sherman; Fiscal Year: 2004..GGF and its receptors have also been implicated in Wallerian degeneration, a process that occurs following nerve injury and which includes that induction of Schwann cell ..
- Axonal Mechanical Sensitivity in NeuritisGeoffrey Bove; Fiscal Year: 2006..The process that occurs following axonal damage is called Wallerian degeneration. This process results in aggregation of macrophages within the perineurium and activation of Schwann cells ..
- CYTOMEGALOVIRUS INFECTION IN DEMYELINATING DISEASESERNESTINA SAXTON; Fiscal Year: 1990..2) To study the process of in vivo reactivation, by immune suppression or by Wallerian degeneration after proximal nerve section. 3) To define the immune mechanisms in demyelination...
- FUNDAMENTAL STUDIES IN SPINAL CORD INJURYPHANOR PEROT; Fiscal Year: 1992..the grant year that were initiated in the last year on secondary changes in the rat spinal cord following Wallerian degeneration and postmortem autolysis which are being compared with the primary traumatic events and are critical to ..
- Enhancing Motor Neuron Regeneration AccuracyRoger Madison; Fiscal Year: 2009..which continues in distal denervated nerve for approximately 30 hours, or until the axon undergoes Wallerian degeneration. The experiments in this proposal build upon this unexpected observation, and will clarify the influence ..
- Axon Regeneration after Spinal Cord Injury in MiceOswald Steward; Fiscal Year: 2009..is due to reinnervation, we will carry out parallel experiments in mice carrying a mutation that delays Wallerian degeneration of synapses (WldS), in which reinnervation is also delayed, and use genetically modified mice that exhibit ..
- The role of capsacin injury on nerve morphology & painJacob Schwarz; Fiscal Year: 2004..We hypothesize that selective lesion of L5 nerve leads to Wallerian degeneration distally and partial Remak bundle denervation...
- CALPAINS IN THE PATHOGENESIS OF DIABETIC NEUROPATHYJonathan Glass; Fiscal Year: 2000..Specific aim 1 is to identify and measure changes in the calpain/calpastatin system during Wallerian degeneration, using specific antibodies and in vitro protease assays...
- Effects of Nerve Injury on GABA A Receptors in the DRGELIJAH FRAKES; Fiscal Year: 2006..L4 DRG is altered as a consequence of these afferents intermingling with injured L5 afferents undergoing Wallerian degeneration in the peripheral nerve...
- ENERGY METABOLISM AND ACUTE EXPERIMENTAL NEUROPATHYJOHN SLADKY; Fiscal Year: 1990..these studies by measuring reactive changes in perfusion and glucose metabolism that follow crush-induced Wallerian degeneration and subsequent regeneration...
- Matrix metalloproteinases as biomarkers of neurodegenerationVeronica Shubayev; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- TRANSDUCTION OF CHRONIC NERVE INJURY BY SCHWANN CELLSRanjan Gupta; Fiscal Year: 2004..As the change in axonal number and function is one of the last events in CNI, this process contrasts to Wallerian degeneration where the loss of axonal integrity leads to the cascade of events...
- PATHOGENESIS AND TREATMENT OF NERVE BLOCK INJURIESRobert Myers; Fiscal Year: 2006..can initiate a painful process of nerve degeneration involving axons and their supporting Schwann cells (Wallerian degeneration) that is followed by a period of endoneurial remodeling resulting in axonal regeneration and remyelination...
- Epo-dependent JAK2 Signaling in Painful NeuropathyWENDY CAMPANA; Fiscal Year: 2006..The experiments will provide new information on the basic mechanisms of nerve injury and pain, and there from, new rationale for development of novel neuroprotective strategies for preventing chronic neuropathic pain. ..
- CDP-choline: Mechanisms in Cerebral IschemiaRAO ADIBHATLA; Fiscal Year: 2006..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
- Signaling Mechanisms mediating effects of Semaphorin3AZhigang He; Fiscal Year: 2005....
- Remark bundle structure and function in neuropathic painJohn W Griffin; Fiscal Year: 2010..The proposed data will have implications for understanding and treating not just pain in partial nerve injuries, but painful neuropathies such as diabetes, causalgia, and postherpetic neuralgia. ..
- Promoting axon regneration and functional recovery after spinal cord injuryZhigang He; Fiscal Year: 2010..We expect that these experiments will provide important insights into the therapeutic potential of manipulating mTOR pathway in promoting axon regrowth and functional recovery after spinal cord injury. ..
- Repair of Bladder Function after Cauda Equina InjuryLeif A Havton; Fiscal Year: 2010..We believe that our proposal has translational research potential for the development of new treatments for patients with conus medullaris/cauda equina injuries. ..
- Utility of Diffusion Tractography for NeurosurgeryRoland Henry; Fiscal Year: 2005..abstract_text> ..
- 2004 Molecular & Cellular Neurobiology Gordon ConferenceLiqun Luo; Fiscal Year: 2004..Majority of which be used to support conference fees and/or travel of students and postdocs from US, especially minority and women participants to increase their number. ..
- MACROPHAGE RECRUITMENT IN NERVOUS SYSTEM INJURY & REPAIRJohn Griffin; Fiscal Year: 2001..recruited into the degenerating PNS and to develop preparations that fail to recruit macrophages during Wallerian degeneration, focusing initially on the hypothesis that activation of the MCP-1 receptor CCR2 is necessary and ..
- MOLECULAR MECHANISMS OF NEURONAL MORPHOGENESISLiqun Luo; Fiscal Year: 2004....
- Hypoglycemic signaling targets in astrocytesJames Mandell; Fiscal Year: 2003..The longterm goal is to develop pharmacologic or molecular methods to augment or modulate neuroprotective aspects of the astrocytic response to hypoglycemia. ..
- URINARY BLADDER MUSCARINIC RECEPTOR SUBTYPESMICHAEL RUGGIERI; Fiscal Year: 2003..3. To characterize the changes in M2 M3 receptor phosphorylation that may accompany receptor desensitization and receptor up and down regulation. ..
- NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERSRiyi Shi; Fiscal Year: 2003..Frequent consultation with a neurosurgeon, who is a member of the research team, will provide necessary input to direct the study and experiments towards clinically relevant solutions for transection nerve injuries. ..
- MAP KINASE SIGNALING IN ASTROGLIAL REACTIONSJames Mandell; Fiscal Year: 2003..3) To generate transgenic mice expressing astrocyte-targeted activators of the ERK/MAPK pathway as critical tests of the working hypothesis. ..
- The role of gender on post-traumatic inflammationHelen Bramlett; Fiscal Year: 2006..Established methods including rodent models of TBI, behavioral tests, as well as immunocytochemical and molecular approaches will be used in this proposal. ..
- Invivo imaging of mouse spinal cord axonal degenerationJiangyang Zhang; Fiscal Year: 2007..The results will then be correlated with ex vivo MR measurements and histopathology. [unreadable] [unreadable] [unreadable]..
- Role of Endogenous Opioid System in the Placebo EffectJames Campbell; Fiscal Year: 2006..3) Identify relationships between the magnitude of the placebo response and regional mu opioid receptor availability in a non-painful condition. ..
- Axonal Protection for Multiple SclerosisJonathan Glass; Fiscal Year: 2007..Combined with immunomodulatory therapy, axonal protection by calpain inhibition may significantly change the course of disease for people with MS. [unreadable] [unreadable]..
- ALCOHOL, HIV, AND THE BRAINAdolf Pfefferbaum; Fiscal Year: 2006..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
- Discovering Calpain Inhibitors for Neurological DiseasesJonathan Glass; Fiscal Year: 2007..The target of our small molecule screen is the calcium-activated protease calpain. Inhibitors of calpain will be developed as novel treatments of neurological diseases. [unreadable] [unreadable] [unreadable]..
- Novel Neuroprotectants for TBIEdward Hall; Fiscal Year: 2008..Thousands experience long lasting brain injury that interferes with their ability to lead productive and full lives. We plan to test a promising new class of therapeutics for traumatic brain injury. [unreadable] [unreadable] [unreadable]..
- CONTROL OF MICROVASCULAR TONE IN TRAUMATIC BRAIN INJURYJose Rafols; Fiscal Year: 2008..unreadable]..
- Nogo receptor and its ligands in axon regenerationZhigang He; Fiscal Year: 2008..These animal models will be used in this study to define the role of myelin inhibitors and other intrinsic and extrinsic factors in limiting the regeneration of different axonal tracts in vivo ..
- Neuroimaging and Recovery after Pediatric Brain InjuryTalin Babikian; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Training Program in Integrative ImmunobiologyVirginia Sanders; Fiscal Year: 2007..In summary, we will provide a multidisciplinary training environment unlike any other for studying the basic science and clinical applications of the immune system in health and disease. ..
- Standards of Scientific ConductMichael Kalichman; Fiscal Year: 2008..Effective teaching about standards of the [unreadable] responsible conduct of research will help to promote public health by fostering integrity in the conduct of biomedical research. [unreadable] [unreadable] [unreadable]..
- Proteomic Markers for ALSJonathan Glass; Fiscal Year: 2008..These candidate biomarkers will be tested for their sensitivity and specificity for disease in plasma and spinal fluid samples from mice and people with ALS. [unreadable] [unreadable] [unreadable]..
- 26th National Neurotrauma Symposium, 2008Edward Hall; Fiscal Year: 2008..Particular efforts are made to actively engage students to participate and interact with leading basic and clinical scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
- Signaling mechanisms of axon regeneration by CNS myelinZhigang He; Fiscal Year: 2009..The second aim will investigate the downstream signaling mechanisms mediated by p75, TROY and perhaps other functionally similar molecules. The involvement of Lingo-1 in this receptor complex will be addressed in the third aim. ..
- Peroxynitrite-Induced Oxidative Damage in TBIEdward Hall; Fiscal Year: 2007..abstract_text> ..
- The Endocytic Machinery of Dendritic SpinesMichael D Ehlers; Fiscal Year: 2010....