wallerian degeneration

Summary

Summary: Degeneration of distal aspects of a nerve axon following injury to the cell body or proximal portion of the axon. The process is characterized by fragmentation of the axon and its MYELIN SHEATH.

Top Publications

  1. ncbi Motor axon excitability during Wallerian degeneration
    Mihai Moldovan
    Division of Neurophysiology, Institute of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Brain 132:511-23. 2009
  2. ncbi Wallerian degeneration, wld(s), and nmnat
    Michael P Coleman
    Laboratory of Molecular Signaling, The Babraham Institute, Cambridge CB223AT, United Kingdom
    Annu Rev Neurosci 33:245-67. 2010
  3. ncbi A longitudinal diffusion tensor imaging study on Wallerian degeneration of corticospinal tract after motor pathway stroke
    Chunshui Yu
    Department of Radiology, Xuanwu Hospital, Capital Medical University, No 45, Chang Chun Street, Xuanwu District, Beijing 100053, PR China
    Neuroimage 47:451-8. 2009
  4. ncbi Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture
    C Pierpaoli
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-5772, USA
    Neuroimage 13:1174-85. 2001
  5. ncbi Why is Wallerian degeneration in the CNS so slow?
    Mauricio E Vargas
    Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Neurosci 30:153-79. 2007
  6. ncbi Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, Czech Republic
    Ann Anat 193:267-75. 2011
  7. ncbi Axon degeneration mechanisms: commonality amid diversity
    Michael Coleman
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Rev Neurosci 6:889-98. 2005
  8. pmc Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects
    K A Sheikh
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 96:7532-7. 1999
  9. pmc Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neuroimage 40:1-10. 2008
  10. pmc A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity
    Yanshan Fang
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 22:590-5. 2012

Detail Information

Publications265 found, 100 shown here

  1. ncbi Motor axon excitability during Wallerian degeneration
    Mihai Moldovan
    Division of Neurophysiology, Institute of Neuroscience and Pharmacology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Brain 132:511-23. 2009
    ..Following loss of axonal continuity, the isolated nerve stump distal to the lesion undergoes Wallerian degeneration in several phases...
  2. ncbi Wallerian degeneration, wld(s), and nmnat
    Michael P Coleman
    Laboratory of Molecular Signaling, The Babraham Institute, Cambridge CB223AT, United Kingdom
    Annu Rev Neurosci 33:245-67. 2010
    ..Here, we review the cellular and molecular events that underlie this process, termed Wallerian degeneration. We describe the biphasic nature of axon degeneration after axotomy and our current understanding of how ..
  3. ncbi A longitudinal diffusion tensor imaging study on Wallerian degeneration of corticospinal tract after motor pathway stroke
    Chunshui Yu
    Department of Radiology, Xuanwu Hospital, Capital Medical University, No 45, Chang Chun Street, Xuanwu District, Beijing 100053, PR China
    Neuroimage 47:451-8. 2009
    b>Wallerian degeneration of the corticospinal tract (CST) after motor pathway ischemic stroke can be characterized by diffusion tensor imaging (DTI)...
  4. ncbi Water diffusion changes in Wallerian degeneration and their dependence on white matter architecture
    C Pierpaoli
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-5772, USA
    Neuroimage 13:1174-85. 2001
    This study investigates water diffusion changes in Wallerian degeneration. We measured indices derived from the diffusion tensor (DT) and T2-weighted signal intensities in the descending motor pathways of patients with small chronic ..
  5. ncbi Why is Wallerian degeneration in the CNS so slow?
    Mauricio E Vargas
    Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Annu Rev Neurosci 30:153-79. 2007
    b>Wallerian degeneration (WD) is the set of molecular and cellular events by which degenerating axons and myelin are cleared after injury. Why WD is rapid and robust in the PNS but slow and incomplete in the CNS is a longstanding mystery...
  6. ncbi Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, Czech Republic
    Ann Anat 193:267-75. 2011
    b>Wallerian degeneration is a cascade of stereotypical events in reaction to injury of nerve fibres...
  7. ncbi Axon degeneration mechanisms: commonality amid diversity
    Michael Coleman
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Rev Neurosci 6:889-98. 2005
    ..dysfunction and an increase in intra-axonal calcium - have been identified by rescuing axons with the slow Wallerian degeneration gene (Wld(S)) and studies with blockers of sodium or calcium influx...
  8. pmc Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects
    K A Sheikh
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 96:7532-7. 1999
    ..Yamamoto, A., Furukawa, K., Yamashiro, S., Shin, M., Okada, M., Fukumoto, S., Haraguchi, M., Takeda, N., Fujimura, K., et al. (1996) Proc. Natl. Acad. Sci. USA 93, 10662-10667]...
  9. pmc Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neuroimage 40:1-10. 2008
    b>Wallerian degeneration plays a significant role in many central nervous system (CNS) diseases. Tracking the progression of Wallerian degeneration may provide better understanding of the evolution of many CNS diseases...
  10. pmc A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity
    Yanshan Fang
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Biol 22:590-5. 2012
    ..Together, these findings demonstrate an essential role of endogenous Nmnat in maintaining axonal integrity that may rely on and function by stabilizing mitochondria...
  11. ncbi Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
    Toshiyuki Araki
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Science 305:1010-3. 2004
    ..In Wallerian degeneration slow (wlds) mice, Wallerian degeneration in response to axonal injury is delayed because of a mutation ..
  12. ncbi ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
    Shuji Wakatsuki
    Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Nat Cell Biol 13:1415-23. 2011
    b>Wallerian degeneration is observed in many neurological disorders, and it is therefore important to elucidate the axonal degeneration mechanism to prevent, and further develop treatment for, such diseases...
  13. pmc Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity
    R Grace Zhai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 4:e416. 2006
    b>Wallerian degeneration refers to a loss of the distal part of an axon after nerve injury...
  14. ncbi Wallerian degeneration: a major component of early axonal pathology in multiple sclerosis
    Tomasz Dziedzic
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Brain Pathol 20:976-85. 2010
    ..However, the contribution of Wallerian degeneration to axonal pathology is not known...
  15. ncbi The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration
    Gerd Meyer zu Horste
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Neurobiol Dis 42:1-8. 2011
    ..Clinical impairments are determined by the amount of axonal loss. Axons of the spontaneous mouse mutant Wallerian degeneration slow (Wlds) show markedly reduced degeneration following various types of injuries...
  16. ncbi Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration
    Laura Conforti
    The Babraham Institute, Cambridge, UK
    FEBS J 278:2666-79. 2011
    ..However, the role of endogenous NMNAT1 in normal axon maintenance and in Wallerian degeneration has not been elucidated yet. To address this question we disrupted the Nmnat1 locus by gene targeting...
  17. ncbi Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration
    Naoki Yahata
    Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    J Neurosci 29:6276-84. 2009
    Studies of naturally occurring mutant mice, wld(s), showing delayed Wallerian degeneration phenotype, suggest that axonal degeneration is an active process...
  18. pmc A local mechanism mediates NAD-dependent protection of axon degeneration
    Jing Wang
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 170:349-55. 2005
    ..of axon degeneration arose from findings that the degeneration of transected axons is delayed in Wallerian degeneration slow (Wlds) mice with the overexpression of a fusion protein with the nicotinamide adenine dinucleotide (..
  19. ncbi TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve
    Veronica I Shubayev
    San Diego VA Healthcare System, CA 92161, USA
    Mol Cell Neurosci 31:407-15. 2006
    ..In mice with delayed Wallerian degeneration (WldS), MMP-9 and tumor necrosis factor alpha (TNFalpha) decline in association with the reduced ..
  20. ncbi Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
    Rudolf Martini
    Department of Neurology, Developmental Neurobiology, University of Wuerzburg, Josef Schneider Strabetae 11, Wuerzburg, Germany
    Glia 56:1566-77. 2008
    ..first discuss the factors that regulate macrophage recruitment, activation, and myelin phagocytosis during Wallerian degeneration and some of the factors involved in the termination of inflammation at the end of the period of Wallerian ..
  21. pmc Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury
    Andrew D Gaudet
    Department of Neuroscience and Center for Brain and Spinal Cord Repair, College of Medicine, The Ohio State University, 770 Biomedical Research Tower, 460 West 12th Ave, Columbus, OH 43210, USA
    J Neuroinflammation 8:110. 2011
    ..Future research will help determine how to manipulate PNS and CNS inflammatory responses in order to improve tissue repair and functional recovery...
  22. ncbi LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease
    Christian Somandin
    Department of Biology, Institute of Molecular Health Sciences, Cell Biology, Swiss Federal Institute of Technology, ETH Zurich, CH 8093 Zurich, Switzerland
    Glia 60:1518-28. 2012
    ..In injured nerves, however, we found that lack of Litaf led to increased numbers of macrophages during Wallerian degeneration, accelerated myelin destruction, and the emergence of more axonal sprouts...
  23. ncbi Extrinsic cellular and molecular mediators of peripheral axonal regeneration
    Frank Bosse
    Molecular Neurobiology Laboratory, Department of Neurology, Medical Faculty, Heinrich Heine University Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Cell Tissue Res 349:5-14. 2012
    ..During this fine-tuned process, named Wallerian degeneration, a remodeling of the distal nerve fragment prepares a permissive microenvironment that permits successful ..
  24. pmc WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering
    Michelle A Avery
    Department of Neurobiology, University of Massachusetts Medical School, and Howard Hughes Medical Institute, Worcester, MA 01605 2324, USA
    Curr Biol 22:596-600. 2012
    Wld(S) (slow Wallerian degeneration) is a remarkable protein that can suppress Wallerian degeneration of axons and synapses, but how it exerts this effect remains unclear...
  25. ncbi Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases
    J T Finn
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 20:1333-41. 2000
    ..We focus on two models of selective axon degeneration: Wallerian degeneration of transected axons and localized axon degeneration induced by local deprivation of neurotrophin...
  26. pmc A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration
    Bradley R Miller
    Department of Developmental Biology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Neurosci 12:387-9. 2009
    ..This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program...
  27. ncbi Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration
    S L Carroll
    Division of Neuropathology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 17:1642-59. 1997
    ..In later stages of Wallerian degeneration, however, Schwann cell mitogenesis markedly decreases, whereas elevated GGF expression persists...
  28. pmc WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity
    Jo Ann V Antenor-Dorsey
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Neurodegener 7:5. 2012
    The WldS mouse mutant ("Wallerian degeneration-slow") delays axonal degeneration in a variety of disorders including in vivo models of Parkinson's disease...
  29. pmc Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomy
    Jiangyang Zhang
    Russel H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 29:3160-71. 2009
    ..These data suggest that there is an early imaging signature associated with axon transections that could be used in a variety of neurological disease processes...
  30. ncbi Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration
    Karine Palin
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Neurobiol Dis 30:19-29. 2008
    ..We show that Wallerian degeneration of the mouse optic nerve induces transcription of TGF-beta1 and TNF-alpha, but not pro-inflammatory ..
  31. ncbi Mechanisms of axonal spheroid formation in central nervous system Wallerian degeneration
    Bogdan Beirowski
    Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom
    J Neuropathol Exp Neurol 69:455-72. 2010
    b>Wallerian degeneration of the CNS is accompanied by axonal dystrophy or swelling...
  32. ncbi Spatiotemporal quantification of tumor necrosis factor-alpha and interleukin-10 after crush injury in rat sciatic nerve utilizing immunohistochemistry
    Tomokazu Sawada
    Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Neurosci Lett 417:55-60. 2007
    ..changes of the tumor necrosis factor-alpha (TNF) and interleukin-10 (IL-10) immunopositive cells during Wallerian degeneration and the following regeneration after crush injury in rat sciatic nerve using immunohistochemistry and ..
  33. ncbi Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo
    Bogdan Beirowski
    Laboratory of Molecular Signalling, The Babraham Institute, Cambridge, UK
    J Neurosci 29:653-68. 2009
    ..The Wallerian degeneration slow (Wld(S)) protein protects axons dose-dependently in many circumstances but is paradoxically abundant ..
  34. ncbi Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration
    Florence E Perrin
    Centre for Research in Neuroscience, McGill University Health Center, Montreal, Quebec, Canada
    Brain 128:854-66. 2005
    b>Wallerian degeneration in the CNS and PNS consists of degradation and phagocytosis of axons and their myelin sheath distal to the site of injury...
  35. ncbi When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI study
    M Di Paola
    Laboratory of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    Neurology 74:1136-42. 2010
    The corpus callosum (CC) has been shown to be susceptible to atrophy in Alzheimer disease (AD) as a correlate of wallerian degeneration or retrogenesis. However, when and where these 2 mechanisms intervene is still unclear.
  36. ncbi The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
    Weiqian Mi
    ZMMK and Institute for Genetics, University of Cologne, Cologne, Germany
    Brain 128:405-16. 2005
    ..The slow Wallerian degeneration gene, Wld(S), delays Wallerian degeneration after injury, and also delays 'dying-back' in peripheral ..
  37. pmc Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system
    Mohamed H Farah
    Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:5744-54. 2011
    ..These observations were reproduced in part by pharmacological inhibition of BACE1. These data suggest BACE1 inhibition as a therapeutic approach to accelerate regeneration and recovery after peripheral nerve damage...
  38. ncbi Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene
    T G Mack
    Center for Molecular Medicine ZMMK and Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50674 Cologne, Germany
    Nat Neurosci 4:1199-206. 2001
    Axons and their synapses distal to an injury undergo rapid Wallerian degeneration, but axons in the C57BL/WldS mouse are protected. The degenerative and protective mechanisms are unknown...
  39. ncbi Degeneration and regeneration of the peripheral nervous system: from Augustus Waller's observations to neuroinflammation
    Guido Stoll
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    J Peripher Nerv Syst 7:13-27. 2002
    ..by a reprint of Augustus Waller's 1850 article, which gave rise to the pathologic process termed Wallerian degeneration. This review is focused on the role of neuroinflammation in Wallerian degeneration and how immune ..
  40. pmc Compartmental neurodegeneration and synaptic plasticity in the Wld(s) mutant mouse
    T H Gillingwater
    Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, UK
    J Physiol 534:627-39. 2001
    ..Studies of the spontaneous mutant Wld(s) mouse, in which Wallerian degeneration is characteristically slow, provide key evidence in support of this hypothesis...
  41. ncbi Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration
    Kazuho Hirata
    Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Microsc Res Tech 57:541-7. 2002
    The literature concerning Schwann cells (SCs) and macrophages in myelin phagocytosis during Wallerian degeneration is reviewed...
  42. pmc Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo
    Stefan Milde
    Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom
    Sci Rep 3:2567. 2013
    ..Overexpression of fluorescently tagged Nmnat2 significantly delays Wallerian degeneration in these mice...
  43. ncbi Axon retraction and degeneration in development and disease
    Liqun Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Annu Rev Neurosci 28:127-56. 2005
    ..Here we review examples of these phenomena and consider potential cellular and molecular mechanisms that underlie axon retraction and degeneration and how they might relate to each other in development and disease...
  44. ncbi WldS mice are resistant to paclitaxel (taxol) neuropathy
    Min Sheng Wang
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Ann Neurol 52:442-7. 2002
    ..strain that demonstrates the remarkable phenotype of prolonged survival of transected axons ("slow Wallerian degeneration")...
  45. ncbi Axonal self-destruction and neurodegeneration
    Martin C Raff
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit and the Biology Department, University College London, London WC1E 6BT, UK
    Science 296:868-71. 2002
    ..Do neurons also use this second program to prune their axonal tree during development and to conserve resources in response to chronic insults?..
  46. ncbi Wallerian degeneration in the corticospinal tract evaluated by diffusion tensor imaging correlates with motor deficit 30 days after middle cerebral artery ischemic stroke
    Josep Puig
    Department of Radiology, Girona Biomedical Research Institute, Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain
    AJNR Am J Neuroradiol 31:1324-30. 2010
    ..We evaluated the anisotropy by using DTI and signal-intensity changes on conventional MR imaging in the CST to determine whether these findings are correlated with limb motor deficit in patients with MCA ischemic stroke...
  47. ncbi Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration
    Qiwei Zhai
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 39:217-25. 2003
    ..In this study, we used the degeneration of transected axons, termed "Wallerian degeneration," as a model to examine the possible involvement of the ubiquitin proteasome system (UPS)...
  48. ncbi Directional diffusion in relapsing-remitting multiple sclerosis: a possible in vivo signature of Wallerian degeneration
    Roland G Henry
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143 1290, USA
    J Magn Reson Imaging 18:420-6. 2003
    ..To examine the role of directional dependence of the apparent diffusion coefficients in the evaluation of normal-appearing brain regions of patients with relapsing-remitting multiple sclerosis...
  49. ncbi Toll-like receptors in peripheral nerve injury and neuropathic pain
    DongHoon Kim
    Program in Molecular and Cellular Neuroscience, DRI, BK21, Department of Oral Physiology, School of Dentistry, Seoul National University, Seoul, Republic of Korea
    Curr Top Microbiol Immunol 336:169-86. 2009
    ..genetically modified mice indicate that Toll-like receptors (TLRs) are involved in nerve degeneration (Wallerian degeneration) and chronic pain (neuropathic pain) development after nerve injury...
  50. ncbi Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila
    Xiao Liang Zhao
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 30:1512-22. 2010
    ..These results suggest that Abeta accumulation depletes presynaptic and axonal mitochondria, leading to other presynaptic deficits...
  51. ncbi Macrophages are eliminated from the injured peripheral nerve via local apoptosis and circulation to regional lymph nodes and the spleen
    T Kuhlmann
    Department of Neuropathology, , Campus Virchow-Klinikum, 13353 Berlin, Germany
    J Neurosci 21:3401-8. 2001
    The present study investigated the fate of macrophages in peripheral nerves undergoing Wallerian degeneration, especially their disappearance from the injured nerves after phagocytosis of axonal and myelin debris...
  52. ncbi Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: implication in Wallerian degeneration
    Hyunkyoung Lee
    Program in Neuroscience, DRI, and Department of Oral Physiology, School of Dentistry, Seoul National University, 28 YeonGun Dong, Jongno gu, Seoul 110 749, Republic of Korea
    Biochem Biophys Res Commun 350:742-7. 2006
    ..In summary, these results suggest that necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3, which might be involved in Wallerian degeneration upon peripheral nerve injury.
  53. ncbi Wallerian degeneration after spinal cord lesions in cats detected with diffusion tensor imaging
    J Cohen-Adad
    GRSNC, Department of Physiology, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada
    Neuroimage 57:1068-76. 2011
    ..This decrease was specific to the type of fibers, i.e., rostrally to the lesion on the dorsal aspect of the cord and caudally to the lesion ipsilaterally, suggesting the detection of Wallerian degeneration.
  54. pmc Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria
    Brandon M Kitay
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, FL 33136, USA
    Hum Mol Genet 22:1601-14. 2013
    ..and recent reports suggest a central role for axonal mitochondria in both degeneration and NMNAT/WLD(S) (Wallerian degeneration slow)-mediated protection...
  55. ncbi The acute phase of Wallerian degeneration: longitudinal diffusion tensor imaging of the fornix following temporal lobe surgery
    Min Liu
    Department of Biomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Neuroimage 74:128-39. 2013
    Numerous animal studies have shown the applicability of diffusion tensor imaging (DTI) to track Wallerian degeneration that occurs after injury to the neural fiber...
  56. ncbi Local production of serum amyloid a is implicated in the induction of macrophage chemoattractants in Schwann cells during wallerian degeneration of peripheral nerves
    So Young Jang
    Department of Physiology, Mitochondria Hub Regulation Center, College of Medicine, Dong A University, Busan, South Korea
    Glia 60:1619-28. 2012
    ..Inflammatory cytokines in the peripheral nerves have been implicated in the Wallerian degeneration of peripheral nerves after injury and in certain types of inflammatory neuropathies...
  57. ncbi Pre-wallerian degeneration in the neonatal brain following perinatal cerebral hypoxia-ischemia demonstrated with MRI
    Floris Groenendaal
    Department of Neonatology, Division of Perinatology and Gynecology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Semin Perinatol 30:146-50. 2006
    Pre-Wallerian degeneration was studied in term and near-term neonates with hypoxic-ischemic brain injury, and related to neurodevelopmental outcome.
  58. ncbi Secretion of ATP from Schwann cells through lysosomal exocytosis during Wallerian degeneration
    Youn Ho Shin
    Department of Anatomy, College of Medicine, Kyung Hee University, Heogi Dong 1, Dongdaemun Gu, Seoul 130 701, Republic of Korea
    Biochem Biophys Res Commun 429:163-7. 2012
    ..that adenosine triphosphate (ATP) is released from Schwann cells through lysosomal exocytosis during Wallerian degeneration and in response to stimulation. In primary Schwann cell cultures, ATP was stored in lysosomal vesicles...
  59. ncbi Extracellular ATP inhibits Schwann cell dedifferentiation and proliferation in an ex vivo model of Wallerian degeneration
    Youn Ho Shin
    Department of Anatomy, College of Medicine, Kyung Hee University, Heogi Dong 1, Dongdaemun Gu, Seoul 130 701, Republic of Korea
    Biochem Biophys Res Commun 430:852-7. 2013
    ..we investigated the role of extracellular ATP in Schwann cell dedifferentiation and proliferation during Wallerian degeneration. Using several markers of Schwann cell dedifferentiation and proliferation in sciatic explants, we found ..
  60. ncbi Toll-like receptor expression in the peripheral nerve
    Sofie Goethals
    Peripheral Neuropathy Group, Department of Molecular Genetics, VIB and University of Antwerp, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Glia 58:1701-9. 2010
    ..Furthermore, acute neurodegeneration induces a shift in TLR expression pattern, most likely illustrating specialized functions of TLRs in basal versus activated conditions of the peripheral nerve...
  61. ncbi Imaging corticospinal degeneration in neonatal rats with unilateral cerebral infarction
    S Lama
    Medical Science, Faculty of Medicine, University of Calgary
    Exp Neurol 228:192-9. 2011
    ..This demonstrates directly the utility of ADC and T(2) MRI to detect acute changes in axons associated with early Wallerian degeneration.
  62. ncbi Biology and pathology of nonmyelinating Schwann cells
    John W Griffin
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Glia 56:1518-31. 2008
    ..Nonmyelin-forming Schwann cells, including those associated with uninjured fibers, have the capacity to act as the "first responders" to injury or disease in their neighborhoods...
  63. ncbi Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo
    Elisabetta Babetto
    The Babraham Institute, Laboratory of Molecular Signalling, Cambridge CB22 3AT, UK
    J Neurosci 30:13291-304. 2010
    ..The chimeric Wallerian degeneration slow protein (Wld(S)) protects axons dose dependently, but its mechanism is still elusive...
  64. ncbi Wallerian degeneration of the pontocerebellar fibers
    Tiziana De Simone
    Department of Neuroradiology, Istituto Nazionale Neurologico C Besta, Milan, Italy
    AJNR Am J Neuroradiol 26:1062-5. 2005
    Two cases of pontine infarct with Wallerian degeneration (WD) of the pontocerebellar fibers are described...
  65. ncbi Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration
    Gerburg Keilhoff
    Institute of Medical Neurobiology, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Exp Neurol 212:189-200. 2008
    ..The negative effect of minocycline on Wallerian degeneration, the essential initial phase of degeneration/regeneration after nerve injury, that was recently ..
  66. pmc Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning
    Seanna M Martin
    Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 137:3985-94. 2010
    ..of injured axons that detach from their cell body break down by the molecularly regulated process of Wallerian degeneration (WD)...
  67. ncbi Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cord
    A Buss
    Department of Neurology, Aachen University Medical School, Georg August Universitat Gottingen, Germany
    Brain 128:356-64. 2005
    Axons undergo Wallerian degeneration (WD) distal to a point of injury. In the lesioned PNS, WD may be followed by successful axonal regeneration and functional recovery...
  68. ncbi Glial and axonal responses in areas of Wallerian degeneration of the corticospinal and dorsal ascending tracts after spinal cord dorsal funiculotomy
    Li Wang
    Department of Neurobiology, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Neuropathology 29:230-41. 2009
    b>Wallerian degeneration (WD), composed of the breakdown and phagocytosis of damaged axons and their myelin sheaths distal to the injury, is a major sequela of spinal cord injury (SCI)...
  69. ncbi Genetic influences on cellular reactions to CNS injury: the reactive response of astrocytes in denervated neuropil regions in mice carrying a mutation (Wld(S)) that causes delayed Wallerian degeneration
    O Steward
    Department of Neuroscience, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Comp Neurol 380:70-81. 1997
    ..denervated neuropil regions in normal mice and in mice carrying the Wld(S) mutation which leads to delayed Wallerian degeneration. In situ hybridization and immunocytochemical techniques were used to define the time course of changes in ..
  70. pmc A conditioning lesion protects axons from degeneration via the Wallenda/DLK MAP kinase signaling cascade
    Xin Xiong
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    J Neurosci 32:610-5. 2012
    ..2010), and overexpression studies indicate that increased Wnd function is sufficient to promote protection from degeneration, we propose that Wnd regulates an adaptive response to injury that allows neurons to cope with axonal stress...
  71. ncbi The chemokine receptor CCR2 is involved in macrophage recruitment to the injured peripheral nervous system
    H Siebert
    Department of Neuropathology, Charite, Humboldt University, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    J Neuroimmunol 110:177-85. 2000
    b>Wallerian degeneration is one of the most elementary reactions of the nervous system after transection of axons, leading to the recruitment of mononuclear cells from the systemic circulation...
  72. ncbi The role of TNF-alpha during Wallerian degeneration
    M Liefner
    Department of Neuropathology, Georg August Universitat, Gottingen, Germany
    J Neuroimmunol 108:147-52. 2000
    The role of TNF-alpha in the course of Wallerian degeneration of the sciatic nerve was studied in control and TNF-alpha deficient mice...
  73. ncbi Involvement of placental growth factor in Wallerian degeneration
    Linda Chaballe
    GIGA Neurosciences, Axonal Regeneration and Cephalic Pain unit, University of Liege, Avenue de l Hopital, Liege, Belgium
    Glia 59:379-96. 2011
    b>Wallerian degeneration (WD) is an inflammatory process of nerve degeneration, which occurs more rapidly in the peripheral nervous system compared with the central nervous system, resulting, respectively in successful and aborted axon ..
  74. ncbi Molecular inflammatory mediators in peripheral nerve degeneration and regeneration
    Carlos Rodrigo Cámara-Lemarroy
    Department of Physiology, Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Mexico
    Neuroimmunomodulation 17:314-24. 2010
    b>Wallerian degeneration, the self-destructive set of cellular and molecular processes by which degenerating axons and myelin are cleared after injury, is initiated by macrophages and Schwann cells...
  75. ncbi Erythropoietin reduces Schwann cell TNF-alpha, Wallerian degeneration and pain-related behaviors after peripheral nerve injury
    W Marie Campana
    Department of Anesthesiology, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Eur J Neurosci 23:617-26. 2006
    Chronic sciatic nerve constriction injury (CCI) induces Wallerian degeneration and exaggerated pain-like behaviors. These effects are mediated in large part by pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha)...
  76. ncbi Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential
    Caroline Sievers
    Center for Molecular Medicine ZMMK and Institute for Genetics, University of Cologne, Germany
    Neurosci Res 46:161-9. 2003
    b>Wallerian degeneration, the disintegration of the distal part of an injured axon, is an important event in many neurodegenerative diseases...
  77. pmc The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves
    Bogdan Beirowski
    Center for Molecular Medicine Cologne CMMC and Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, D 50647 Cologne, Germany
    BMC Neurosci 6:6. 2005
    The progressive nature of Wallerian degeneration has long been controversial...
  78. ncbi Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation
    K Suzuki
    Molecular Neurobiology Laboratory, Division of Life Science, Graduate School of Life Science, Hokkaido University, North Ward N10 W8, Sapporo 060 0810, Japan
    Neuroscience 147:599-612. 2007
    It has been shown that Wallerian degeneration, an anterograde degeneration of transected axons, is markedly delayed in a mutant mouse called slow Wallerian degeneration (Wld(S))...
  79. ncbi Very early activation of m-calpain in peripheral nerve during Wallerian degeneration
    Jonathan D Glass
    Department of Neurology, Emory University School of Medicine, 1639 Pierce Drive, Suite 6000, Atlanta, GA 30322, USA
    J Neurol Sci 196:9-20. 2002
    ..Peripheral nerve injury results in a series of events culminating in degradation of the axonal cytoskeleton (Wallerian degeneration)...
  80. pmc Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells
    A Saada
    Department of Anatomy and Embryology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Cell Biol 133:159-67. 1996
    Peripheral nerve injury is followed by Wallerian degeneration which is characterized by cellular and molecular events that turn the degenerating nerve into a tissue that supports nerve regeneration...
  81. ncbi Glial cell responses, complement, and clusterin in the central nervous system following dorsal root transection
    L Liu
    Department of Anatomy, Biomedical Center, Uppsala University, Sweden
    Glia 23:221-38. 1998
    ..cascade, including the putative complement inhibitor clusterin, and their cellular association during Wallerian degeneration in the central nervous system...
  82. ncbi Delayed wallerian degeneration in sciatic nerves of C57BL/Ola mice is associated with impaired regeneration of sensory axons
    M A Bisby
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Brain Res 530:117-20. 1990
    b>Wallerian degeneration is delayed following sciatic nerve crush in C57BL/Ola mice. Compared to C57BL/6J mice, regeneration of sensory axons is significantly slowed in the Ola mice, but reinnervation does eventually occur...
  83. ncbi Hereditary absence of complement C5 in adult mice influences Wallerian degeneration, but not retrograde responses, following injury to peripheral nerve
    L Liu
    Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
    J Peripher Nerv Syst 4:123-33. 1999
    ..These findings elucidate new aspects on the functional role of the complement system in the peripheral nervous system following peripheral nerve injury...
  84. ncbi Delayed glial cell death following wallerian degeneration in white matter tracts after spinal cord dorsal column cordotomy in adult rats
    P Warden
    Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, Missouri 63104, USA
    Exp Neurol 168:213-24. 2001
    ..the secondary injury processes occurring after SCI, we investigated the relationship between apoptosis and Wallerian degeneration in spinal white matter tracts...
  85. ncbi The role of macrophages in Wallerian degeneration
    W Bruck
    Department of Neuropathology, University of Gottingen, Germany
    Brain Pathol 7:741-52. 1997
    The present review focuses on macrophage properties in Wallerian degeneration. The identification of hematogenous phagocytes, the involvement of cell surface receptors and soluble factors, the state of activation during myelin removal and ..
  86. ncbi Corticospinal tract pre-wallerian degeneration: a novel outcome predictor for pediatric stroke on acute MRI
    Trish Domi
    Children s Stroke Program, The Hospital for Sick Children and Institute for Medical Science, University of Toronto, Toronto, ON, Canada
    Stroke 40:780-7. 2009
    In neonatal arterial ischemic stroke, pre-Wallerian degeneration in descending corticospinal tracts (DCST) on diffusion MRI (DWI) predicts poor outcome. This signal has not been studied in older children.
  87. ncbi Focal Wallerian degeneration of the corpus callosum in large middle cerebral artery stroke: serial diffusion tensor imaging
    Rakesh K Gupta
    Department of Radiodiagnosis, King George s Medical University, Lucknow, India
    J Magn Reson Imaging 24:549-55. 2006
    To detect lesion-related focal Wallerian degeneration (WD) changes in different segments of the corpus callosum (CC) in patients with large middle cerebral arterial (MCA) territory stroke using diffusion tensor imaging (DTI).
  88. ncbi Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent
    R Wagner
    Department of Anesthesiology at the Veterans Administration Medical Center and the University of California San Diego, La Jolla 92093 0629, USA
    Pain 77:173-9. 1998
    ..Experimental inflammatory compression injury to the sciatic nerve (chronic constriction injury, CCI) induces Wallerian degeneration of axons and damages non-neuronal cells at the injury site in association with the development of ..
  89. pmc Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
    Miri Gitik
    Dept of Medical Neurobiology, IMRIC, Hebrew University Hadassah Medical School, P O B 12272, Jerusalem 91120, Israel
    J Neuroinflammation 8:24. 2011
    ..produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops...
  90. ncbi Nature of signals that initiate the immune response during Wallerian degeneration of peripheral nerves
    S Karanth
    Department of Neurosurgery, Centre for Neuroscience, Barts and The London, Queen Marys School of Medicine, University of London, The Royal London Hospital, London E1 1BB, UK
    Exp Neurol 202:161-6. 2006
    Monocyte chemoattractant protein-1 is produced by Schwann cells during Wallerian degeneration of a peripheral nerve and contributes to a selective accumulation of macrophages in the degenerating segment...
  91. ncbi Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging
    Martin Bendszus
    Department of Neuroradiology, University of Wurzburg, D 97080 Wurzburg, Germany
    J Neurosci 23:10892-6. 2003
    ..SPIO-enhanced MRI provides a new tool to selectively visualize active periods of macrophage transmigration into the nervous system, thus enabling dynamic views on a fundamental process in a multitude of nerve disorders...
  92. ncbi Wallerian degeneration after crush injury of rat sciatic nerve increases endo- and epineurial tumor necrosis factor-alpha protein
    Annette George
    Neurologische Klinik der Universität Würzburg, Wurzburg, Germany
    Neurosci Lett 372:215-9. 2004
    ..IHC revealed prominent TNF-immunoreactivity in many epineurial macrophages on days 0.5 to 3 after crush injury. These data indicate that TNF protein is early and transiently upregulated at the site of peripheral nerve trauma...
  93. ncbi Calpain-mediated cleavage of collapsin response mediator protein(CRMP)-2 during neurite degeneration in mice
    Ekatherina Touma
    Molecular Neurobiology Laboratory, Graduate School of Life Science, Hokkaido University, Sapporo 060 0810, Japan
    Eur J Neurosci 26:3368-81. 2007
    ..No cleavage of CRMP-2 or -4 occurred in NGF-deprived neurites from Wld(s) (Wallerian degeneration slow) mutant mice in which neurite degeneration is markedly delayed...
  94. ncbi A Wallerian degeneration pattern in patients at risk for MS
    J H Simon
    Neuroradiology MRI Department, University of Colorado Health Sciences Center, Denver 80262, USA
    Neurology 54:1155-60. 2000
    ..In theory, axonal injury may occur in the focal areas characterized by early inflammation, or can be more distant, as in Wallerian degeneration. However, Wallerian degeneration is thought of as a rare or a late finding in MS.
  95. ncbi Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury
    Audrey Boivin
    Laboratory of Molecular Endocrinology, CHUL Research Center, and Department of Anatomy and Physiology, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada G1V 4G2
    J Neurosci 27:12565-76. 2007
    ..Here, we investigated whether TLRs are involved in regulating the immune response, Wallerian degeneration (WD), and nerve regeneration after sciatic nerve lesion...
  96. pmc Wallerian degeneration: the innate-immune response to traumatic nerve injury
    Shlomo Rotshenker
    Dept of Medical Neurobiology, IMRIC, Hebrew University, Faculty of Medicine, Jerusalem, Israel
    J Neuroinflammation 8:109. 2011
    ..Recovery by regeneration depends on the cellular and molecular events of Wallerian degeneration that injury induces distal to the lesion site, the domain through which severed axons regenerate back to ..
  97. ncbi Acute corticospinal tract Wallerian degeneration is associated with stroke outcome
    Giselle DeVetten
    Seaman Family MR Research Centre, Foothills Medical Centre, Alberta Health Services, Alberta, Canada
    Stroke 41:751-6. 2010
    In children with stroke, poor motor outcome is associated with early Wallerian degeneration of the corticospinal tract that is seen on diffusion-weighted MRI...
  98. ncbi Canadian Association of Neuroscience review: axonal regeneration in the peripheral and central nervous systems--current issues and advances
    Keith Fenrich
    Centre for Neuroscience, Division of Physical Medicine and Rehabilitation, University of Alberta, Edmonton, AB, Canada
    Can J Neurol Sci 31:142-56. 2004
    ..Strategies to overcome these limitations in the PNS are considered in detail and contrasted with strategies in the CNS...
  99. ncbi NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration
    L Conforti
    The Babraham Institute, Cambridge CB2 4AT, UK
    Cell Death Differ 14:116-27. 2007
    The slow Wallerian degeneration protein (Wld(S)), a fusion protein incorporating full-length nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1), delays axon degeneration caused by injury, toxins and genetic mutation...
  100. ncbi All roads lead to disconnection?--Traumatic axonal injury revisited
    A Buki
    Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
    Acta Neurochir (Wien) 148:181-93; discussion 193-4. 2006
    ..The anterograde and retrograde consequences of TAI are also considered together with a discussion of various experimental therapeutic approaches capable of attenuating TAI...
  101. ncbi Gradual loss of myelin and formation of an astrocytic scar during Wallerian degeneration in the human spinal cord
    A Buss
    Department of Neurology, Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
    Brain 127:34-44. 2004
    Axons undergo Wallerian degeneration distal to a point of injury. Experimental investigations have documented many of the cellular and molecular events that underlie this behaviour...

Research Grants62

  1. A zebrafish model for neural regeneration
    ALLISON F ROSENBERG; Fiscal Year: 2012
    ..Immediately after nerve injury, an active process of axonal degeneration, termed Wallerian degeneration, ensues...
  2. Diabetes suppresses sympathetic neurotransmission and thereby glucagon secretion
    Gerald J Taborsky; Fiscal Year: 2013
    ..To prevent hyperglycemia-induced suppression of sympathetic ganglionic neurotransmission, we will use the Wallerian Degeneration Slow (Wlds) rat which our new Preliminary Data show to be resistant to this form of neural dysfunction...
  3. Neuronal events and molecular pathways in active dendrite degeneration
    Melissa Rolls; Fiscal Year: 2010
    ..that this injury elicits an active degeneration program similar to axon degeneration after transection (Wallerian degeneration): distal dendrites are completely disassembled within 24 hours, and this disassembly is blocked by ..
  4. Inflammation and delayed cognitive dysfunction after stroke
    KRISTIAN PAUL DOYLE; Fiscal Year: 2013
    ..We hypothesize that this inflammatory response is in response to Wallerian degeneration of the axons that project from the stroke lesion...
  5. Molecular Mechanisms of Axon Degeneration
    Marc R Freeman; Fiscal Year: 2013
    ..Studies of axon degeneration after axotomy (i.e. Wallerian degeneration) have proven an extremely useful approach to elucidate fundamental cellular events driving axon auto-..
  6. The role of Sirt1 in Huntington's Disease.
    Dimitri Krainc; Fiscal Year: 2013
    ..SIRT1 protects from Wallerian degeneration and protects against neurodegeneration in models of Alzheimer's disease, Amyotrophic lateral ..
  7. Mechanisms of Neuronal Maintenance and Protection.
    Rong Grace Zhai; Fiscal Year: 2013
    ..enzyme, and the neuroprotective function of NMNAT has also been implicated in a mouse model of slow Wallerian Degeneration. Currently, the detailed mechanisms of this maintenance function and the protective capability of NMNAT in ..
  8. Understanding neuronal and axonal degeneration in a murine model of human MS
    Shu Wei Sun; Fiscal Year: 2013
    ..Prolonged injury can induce Wallerian degeneration, a process of neuronal apoptosis, resulting in damage that propagates along axons and leads to the cell ..
  9. A novel bioengineered technique to rapidly and permanently repair cut PNS nerves
    GEORGE DAVIS BITTNER; Fiscal Year: 2013
    ..We retard Wallerian degeneration by cooling or cyclosporin A and then repair axons chronically severed for up 10 days by PEG-fusion...
  10. Spinal Cord-to-Computer Interface
    Mesut Sahin; Fiscal Year: 2013
    ..The distal portions of the severed motor axons go through Wallerian degeneration. However, the proximal part of the axon continues to function years after injury since its connection to ..
  11. Synaptic damage in models of beta-amyloid associated pathology
    Edward H Koo; Fiscal Year: 2011
    ..The third Aim will examine the phenotype of APP transgenic mice crossed to the WLDs (slow Wallerian degeneration) mutant mice...
  12. NEURONAL DEVELOPMENT INTERACTION AND ORGANIZATION
    Michael Bennett; Fiscal Year: 2000
    ..The role of these connexins in normal development and Wallerian degeneration following nerve lesions will be investigated using wild type and connexin knockout mice...
  13. Signal Transduction in Myelinating Cells
    Charles Stiles; Fiscal Year: 2006
    ..unreadable] [unreadable] A favored biological context to address signaling in myelinated axons is the Wallerian degeneration response of rodent sciatic nerve...
  14. CELL DEATH IN THE OLIGODENDROGLIAL LINEAGE
    Judith Grinspan; Fiscal Year: 1999
    ..Cell death also has been detected in several dysmyelinating mutations in rodents and following Wallerian degeneration of the optic nerve...
  15. Diffusion Tensor Imaging of Wallerian Degeneration in MS
    Khader Hasan; Fiscal Year: 2009
    ..may include inflammation, demyelination, gliosis, direct axonal loss directly or indirectly through Wallerian degeneration (WD)...
  16. Connexins in Nerve Regeneration and Inherited Neuropathy
    Charles Abrams; Fiscal Year: 2009
    ..its expression levels are regulated by GGF (which is thought to induce Schwann cell proliferation during Wallerian degeneration);and 3) loss of Cx32 mediated cell-cell channels leads to increased Schwann cell death...
  17. AXONAL TRANSPORT AND PERIPHERAL NERVE FUNCTION
    Kimberly Topp; Fiscal Year: 2001
    ..Interruption of axonal transport leads to Wallerian degeneration of axons distal to the site of impairment...
  18. ROLE OF CD44 IN PERIPHERAL NERVE DEVELOPMENT AND INJURY
    Larry Sherman; Fiscal Year: 2004
    ..GGF and its receptors have also been implicated in Wallerian degeneration, a process that occurs following nerve injury and which includes that induction of Schwann cell ..
  19. Axonal Mechanical Sensitivity in Neuritis
    Geoffrey Bove; Fiscal Year: 2006
    ..The process that occurs following axonal damage is called Wallerian degeneration. This process results in aggregation of macrophages within the perineurium and activation of Schwann cells ..
  20. CYTOMEGALOVIRUS INFECTION IN DEMYELINATING DISEASES
    ERNESTINA SAXTON; Fiscal Year: 1990
    ..2) To study the process of in vivo reactivation, by immune suppression or by Wallerian degeneration after proximal nerve section. 3) To define the immune mechanisms in demyelination...
  21. FUNDAMENTAL STUDIES IN SPINAL CORD INJURY
    PHANOR PEROT; Fiscal Year: 1992
    ..the grant year that were initiated in the last year on secondary changes in the rat spinal cord following Wallerian degeneration and postmortem autolysis which are being compared with the primary traumatic events and are critical to ..
  22. Enhancing Motor Neuron Regeneration Accuracy
    Roger Madison; Fiscal Year: 2009
    ..which continues in distal denervated nerve for approximately 30 hours, or until the axon undergoes Wallerian degeneration. The experiments in this proposal build upon this unexpected observation, and will clarify the influence ..
  23. Axon Regeneration after Spinal Cord Injury in Mice
    Oswald Steward; Fiscal Year: 2009
    ..is due to reinnervation, we will carry out parallel experiments in mice carrying a mutation that delays Wallerian degeneration of synapses (WldS), in which reinnervation is also delayed, and use genetically modified mice that exhibit ..
  24. The role of capsacin injury on nerve morphology & pain
    Jacob Schwarz; Fiscal Year: 2004
    ..We hypothesize that selective lesion of L5 nerve leads to Wallerian degeneration distally and partial Remak bundle denervation...
  25. CALPAINS IN THE PATHOGENESIS OF DIABETIC NEUROPATHY
    Jonathan Glass; Fiscal Year: 2000
    ..Specific aim 1 is to identify and measure changes in the calpain/calpastatin system during Wallerian degeneration, using specific antibodies and in vitro protease assays...
  26. Effects of Nerve Injury on GABA A Receptors in the DRG
    ELIJAH FRAKES; Fiscal Year: 2006
    ..L4 DRG is altered as a consequence of these afferents intermingling with injured L5 afferents undergoing Wallerian degeneration in the peripheral nerve...
  27. ENERGY METABOLISM AND ACUTE EXPERIMENTAL NEUROPATHY
    JOHN SLADKY; Fiscal Year: 1990
    ..these studies by measuring reactive changes in perfusion and glucose metabolism that follow crush-induced Wallerian degeneration and subsequent regeneration...
  28. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. TRANSDUCTION OF CHRONIC NERVE INJURY BY SCHWANN CELLS
    Ranjan Gupta; Fiscal Year: 2004
    ..As the change in axonal number and function is one of the last events in CNI, this process contrasts to Wallerian degeneration where the loss of axonal integrity leads to the cascade of events...
  30. PATHOGENESIS AND TREATMENT OF NERVE BLOCK INJURIES
    Robert Myers; Fiscal Year: 2006
    ..can initiate a painful process of nerve degeneration involving axons and their supporting Schwann cells (Wallerian degeneration) that is followed by a period of endoneurial remodeling resulting in axonal regeneration and remyelination...
  31. Epo-dependent JAK2 Signaling in Painful Neuropathy
    WENDY CAMPANA; Fiscal Year: 2006
    ..The experiments will provide new information on the basic mechanisms of nerve injury and pain, and there from, new rationale for development of novel neuroprotective strategies for preventing chronic neuropathic pain. ..
  32. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  33. Signaling Mechanisms mediating effects of Semaphorin3A
    Zhigang He; Fiscal Year: 2005
    ....
  34. Remark bundle structure and function in neuropathic pain
    John W Griffin; Fiscal Year: 2010
    ..The proposed data will have implications for understanding and treating not just pain in partial nerve injuries, but painful neuropathies such as diabetes, causalgia, and postherpetic neuralgia. ..
  35. Promoting axon regneration and functional recovery after spinal cord injury
    Zhigang He; Fiscal Year: 2010
    ..We expect that these experiments will provide important insights into the therapeutic potential of manipulating mTOR pathway in promoting axon regrowth and functional recovery after spinal cord injury. ..
  36. Repair of Bladder Function after Cauda Equina Injury
    Leif A Havton; Fiscal Year: 2010
    ..We believe that our proposal has translational research potential for the development of new treatments for patients with conus medullaris/cauda equina injuries. ..
  37. Utility of Diffusion Tractography for Neurosurgery
    Roland Henry; Fiscal Year: 2005
    ..abstract_text> ..
  38. 2004 Molecular & Cellular Neurobiology Gordon Conference
    Liqun Luo; Fiscal Year: 2004
    ..Majority of which be used to support conference fees and/or travel of students and postdocs from US, especially minority and women participants to increase their number. ..
  39. MACROPHAGE RECRUITMENT IN NERVOUS SYSTEM INJURY & REPAIR
    John Griffin; Fiscal Year: 2001
    ..recruited into the degenerating PNS and to develop preparations that fail to recruit macrophages during Wallerian degeneration, focusing initially on the hypothesis that activation of the MCP-1 receptor CCR2 is necessary and ..
  40. MOLECULAR MECHANISMS OF NEURONAL MORPHOGENESIS
    Liqun Luo; Fiscal Year: 2004
    ....
  41. Hypoglycemic signaling targets in astrocytes
    James Mandell; Fiscal Year: 2003
    ..The longterm goal is to develop pharmacologic or molecular methods to augment or modulate neuroprotective aspects of the astrocytic response to hypoglycemia. ..
  42. URINARY BLADDER MUSCARINIC RECEPTOR SUBTYPES
    MICHAEL RUGGIERI; Fiscal Year: 2003
    ..3. To characterize the changes in M2 M3 receptor phosphorylation that may accompany receptor desensitization and receptor up and down regulation. ..
  43. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..Frequent consultation with a neurosurgeon, who is a member of the research team, will provide necessary input to direct the study and experiments towards clinically relevant solutions for transection nerve injuries. ..
  44. MAP KINASE SIGNALING IN ASTROGLIAL REACTIONS
    James Mandell; Fiscal Year: 2003
    ..3) To generate transgenic mice expressing astrocyte-targeted activators of the ERK/MAPK pathway as critical tests of the working hypothesis. ..
  45. The role of gender on post-traumatic inflammation
    Helen Bramlett; Fiscal Year: 2006
    ..Established methods including rodent models of TBI, behavioral tests, as well as immunocytochemical and molecular approaches will be used in this proposal. ..
  46. Invivo imaging of mouse spinal cord axonal degeneration
    Jiangyang Zhang; Fiscal Year: 2007
    ..The results will then be correlated with ex vivo MR measurements and histopathology. [unreadable] [unreadable] [unreadable]..
  47. Role of Endogenous Opioid System in the Placebo Effect
    James Campbell; Fiscal Year: 2006
    ..3) Identify relationships between the magnitude of the placebo response and regional mu opioid receptor availability in a non-painful condition. ..
  48. Axonal Protection for Multiple Sclerosis
    Jonathan Glass; Fiscal Year: 2007
    ..Combined with immunomodulatory therapy, axonal protection by calpain inhibition may significantly change the course of disease for people with MS. [unreadable] [unreadable]..
  49. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  50. Discovering Calpain Inhibitors for Neurological Diseases
    Jonathan Glass; Fiscal Year: 2007
    ..The target of our small molecule screen is the calcium-activated protease calpain. Inhibitors of calpain will be developed as novel treatments of neurological diseases. [unreadable] [unreadable] [unreadable]..
  51. Novel Neuroprotectants for TBI
    Edward Hall; Fiscal Year: 2008
    ..Thousands experience long lasting brain injury that interferes with their ability to lead productive and full lives. We plan to test a promising new class of therapeutics for traumatic brain injury. [unreadable] [unreadable] [unreadable]..
  52. CONTROL OF MICROVASCULAR TONE IN TRAUMATIC BRAIN INJURY
    Jose Rafols; Fiscal Year: 2008
    ..unreadable]..
  53. Nogo receptor and its ligands in axon regeneration
    Zhigang He; Fiscal Year: 2008
    ..These animal models will be used in this study to define the role of myelin inhibitors and other intrinsic and extrinsic factors in limiting the regeneration of different axonal tracts in vivo ..
  54. Neuroimaging and Recovery after Pediatric Brain Injury
    Talin Babikian; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. Training Program in Integrative Immunobiology
    Virginia Sanders; Fiscal Year: 2007
    ..In summary, we will provide a multidisciplinary training environment unlike any other for studying the basic science and clinical applications of the immune system in health and disease. ..
  56. Standards of Scientific Conduct
    Michael Kalichman; Fiscal Year: 2008
    ..Effective teaching about standards of the [unreadable] responsible conduct of research will help to promote public health by fostering integrity in the conduct of biomedical research. [unreadable] [unreadable] [unreadable]..
  57. Proteomic Markers for ALS
    Jonathan Glass; Fiscal Year: 2008
    ..These candidate biomarkers will be tested for their sensitivity and specificity for disease in plasma and spinal fluid samples from mice and people with ALS. [unreadable] [unreadable] [unreadable]..
  58. 26th National Neurotrauma Symposium, 2008
    Edward Hall; Fiscal Year: 2008
    ..Particular efforts are made to actively engage students to participate and interact with leading basic and clinical scientists. [unreadable] [unreadable] [unreadable] [unreadable]..
  59. Signaling mechanisms of axon regeneration by CNS myelin
    Zhigang He; Fiscal Year: 2009
    ..The second aim will investigate the downstream signaling mechanisms mediated by p75, TROY and perhaps other functionally similar molecules. The involvement of Lingo-1 in this receptor complex will be addressed in the third aim. ..
  60. Peroxynitrite-Induced Oxidative Damage in TBI
    Edward Hall; Fiscal Year: 2007
    ..abstract_text> ..
  61. The Endocytic Machinery of Dendritic Spines
    Michael D Ehlers; Fiscal Year: 2010
    ....