retrograde degeneration

Summary

Summary: Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.

Top Publications

  1. pmc Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit
    Anh H Pham
    Division of Biology, California Institute of Technology, 1200 E California Boulevard, Pasadena, CA 91125, USA
    Hum Mol Genet 21:4817-26. 2012
  2. ncbi Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans
    Alan Cowey
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX13UD, UK
    Brain 134:2149-57. 2011
  3. pmc Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons
    C Penas
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Spain
    Cell Death Differ 18:1617-27. 2011
  4. ncbi Transneuronal retrograde degeneration of the retinal ganglion cells in patients with cerebral infarction
    Hae Young Lopilly Park
    Department of Ophthalmology and Visual Science, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Ophthalmology 120:1292-9. 2013
  5. pmc Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy
    Hsiao Chun Cheng
    Departments of Neurology and Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Neurosci 31:2125-35. 2011
  6. ncbi Retrograde degeneration of the corticospinal tract associated with pontine infarction
    Shunsuke Kobayashi
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Neurol Sci 236:91-3. 2005
  7. pmc Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons
    Joke Dhondt
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
    FASEB J 25:1461-73. 2011
  8. ncbi Longitudinal investigations on the anterograde and retrograde degeneration in the pyramidal tract following pontine infarction with diffusion tensor imaging
    Zhijian Liang
    Department of Neurology and Stroke Centre, Sun Yat Sen University, Guangzhou, PR China
    Cerebrovasc Dis 25:209-16. 2008
  9. ncbi Thalamic retrograde degeneration in the congenitally hydrocephalic rat is attributable to apoptotic cell death
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 22:186-93. 2002
  10. ncbi Effects of pinealectomy and melatonin on the retrograde degeneration of retinal ganglion cells in a novel model of intraorbital optic nerve transection in mice
    Ertugrul Kilic
    Department of Neurology, University of Tubingen, Germany
    J Pineal Res 32:106-11. 2002

Research Grants

  1. The shape and circuitry of neurons in the retina.
    MARGARET MACNEIL; Fiscal Year: 2012
  2. EXCITOTOXIC MECHANISMS IN POST TRAUMATIC NEURONAL DEATH
    Douglas Ross; Fiscal Year: 1992
  3. IMPLANTED ELECTRODE-ARRAYS QUANTIFY NERVE REGENERATION
    Christian Krarup; Fiscal Year: 1990
  4. HUMAN MODEL OF VESTIBULAR DEAFFERENTATION
    Akira Ishiyama; Fiscal Year: 2001
  5. REORGANIZATION AFTER BRAIN INJURY
    JAIME VILLABLANCA; Fiscal Year: 1990
  6. NEUROTROPHIC FACTORS AND CNS TRANSPLANTATION
    GREGORY HELM; Fiscal Year: 1999
  7. MOTOR NEURON DISEASES AND TROPHIC THERAPIES
    Donald Price; Fiscal Year: 2000
  8. MECHANISMS OF NEURONAL APOPTOSIS IN VIVO
    Lee Martin; Fiscal Year: 2009
  9. CELLULAR TOXICOLOGY OF THE DOPAMINE NEURON
    Juan Sanchez Ramos; Fiscal Year: 1990
  10. HISTOCHEMICAL STUDIES OF HUNTINGTON'S DISEASE BRAIN
    Neil Kowall; Fiscal Year: 1992

Detail Information

Publications197 found, 100 shown here

  1. pmc Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit
    Anh H Pham
    Division of Biology, California Institute of Technology, 1200 E California Boulevard, Pasadena, CA 91125, USA
    Hum Mol Genet 21:4817-26. 2012
    ..Our findings indicate that perturbations of mitochondrial dynamics can cause nigrostriatal defects and may be a risk factor for the neurodegeneration in PD...
  2. ncbi Transneuronal retrograde degeneration of retinal ganglion cells and optic tract in hemianopic monkeys and humans
    Alan Cowey
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX13UD, UK
    Brain 134:2149-57. 2011
    Transneuronal retrograde degeneration of retinal ganglion cells after removal of primary visual cortex (area V1) is well established by quantitative neurohistological analysis of the ganglion cell layer in monkeys, but remains ..
  3. pmc Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons
    C Penas
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Spain
    Cell Death Differ 18:1617-27. 2011
    ..Besides, Bcl2 is strongly implicated in the survival pathway activated by BiP overexpression...
  4. ncbi Transneuronal retrograde degeneration of the retinal ganglion cells in patients with cerebral infarction
    Hae Young Lopilly Park
    Department of Ophthalmology and Visual Science, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Ophthalmology 120:1292-9. 2013
    The objective of this study was to determine whether transneuronal retrograde degeneration (TRD) of the retinal ganglion cells (RGCs) could be detected by optical coherence tomography (OCT) in humans with lesions other than of the ..
  5. pmc Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy
    Hsiao Chun Cheng
    Departments of Neurology and Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Neurosci 31:2125-35. 2011
    ..autophagy mediator Atg7 in adult mice also achieves striking axon protection in these acute models of retrograde degeneration. The protection afforded by both Myr-Akt and Atg7 deletion is robust and lasting, because it is still ..
  6. ncbi Retrograde degeneration of the corticospinal tract associated with pontine infarction
    Shunsuke Kobayashi
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Neurol Sci 236:91-3. 2005
    ..An autopsy confirmed the existence of retrograde degeneration extending from the pons to the internal capsule, evidence that retrograde degeneration in the ..
  7. pmc Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons
    Joke Dhondt
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
    FASEB J 25:1461-73. 2011
    ..Concomitantly, mice lacking VEGF-B or a functional FLT1 developed more retrograde degeneration of sensory neurons in a model of distal neuropathy...
  8. ncbi Longitudinal investigations on the anterograde and retrograde degeneration in the pyramidal tract following pontine infarction with diffusion tensor imaging
    Zhijian Liang
    Department of Neurology and Stroke Centre, Sun Yat Sen University, Guangzhou, PR China
    Cerebrovasc Dis 25:209-16. 2008
    ..stroke has been detected by some studies using diffusion tensor imaging (DTI), but the anterograde and retrograde degeneration in pyramidal tract after pontine infarction and its potential clinical significance are not well ..
  9. ncbi Thalamic retrograde degeneration in the congenitally hydrocephalic rat is attributable to apoptotic cell death
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 22:186-93. 2002
    ..These findings suggest that the neuronal cell death observed in the thalamus in hydrocephalic HTX rats is retrograde degeneration due to extensive damage of axons in the cerebral white matter and that the thalamic retrograde ..
  10. ncbi Effects of pinealectomy and melatonin on the retrograde degeneration of retinal ganglion cells in a novel model of intraorbital optic nerve transection in mice
    Ertugrul Kilic
    Department of Neurology, University of Tubingen, Germany
    J Pineal Res 32:106-11. 2002
    The effects of pinealectomy and of intraperitoneally administered melatonin on the retrograde degeneration of retinal ganglion cells (RGCs) were examined in a novel model of optic nerve (ON) transection in C57BL/16J mice...
  11. ncbi Activation of the c-Jun transcription factor following neurodegeneration in vivo
    Johannes Schenkel
    Institut fur Physiologie und Pathophysiologie, Universitat Heidelberg, Im Neuenheimer Feld 326, D 69120 Heidelberg, Germany
    Neurosci Lett 361:36-9. 2004
    ....
  12. ncbi Insulin-like growth factor I induced survival of axotomized olfactory neurons in the chick
    M Mathonnet
    , 2 rue du Dr Marcland, 87025 Limoges, Cedex, France
    Neurosci Lett 308:67-70. 2001
    ..It reveals a long lasting effect of IGF1 on the survival of lesioned olfactory neurons and transient effects on maintenance of differentiation and mitosis stimulation...
  13. ncbi Myosin II activity is required for severing-induced axon retraction in vitro
    Gianluca Gallo
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Exp Neurol 189:112-21. 2004
    ..These data demonstrate that myosin II activity is required for severing-induced axon retraction in vitro, and suggest myosin II as a target for therapeutic interventions aimed at minimizing retraction following severing in vivo...
  14. pmc Influence of injury severity on the rate and magnitude of the T lymphocyte and neuronal response to facial nerve axotomy
    Grace K Ha
    Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    J Neuroimmunol 199:18-23. 2008
    ..Altogether, these data suggest that the trafficking of T cells to the injured FMN is dependent upon the severity of peripheral nerve injury and associated neuronal death...
  15. ncbi Integration of retrograde axonal and nuclear transport mechanisms in neurons: implications for therapeutics
    Shlomit Hanz
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Neuroscientist 10:404-8. 2004
    ....
  16. ncbi Interleukin-6 (IL6) and cellular response to facial nerve injury: effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL6-deficient mice
    M Galiano
    Department of Neuromorphology, Max-Planck Institute for Neurobiology, Am Klopferspitz 18a, D-82152 Martinsried, Germany
    Eur J Neurosci 14:327-41. 2001
    ..However, the particularly strong actions on lymphocytes and microglia suggest that this cytokine plays a central role in the initiation of immune surveillance in the injured central nervous system...
  17. ncbi Spinal axonal injury transiently elevates the level of metabotropic glutamate receptor 5, but not 1, in cord-projection central neurons
    Yueh Jan Wang
    Department of Anatomy, College of Medicine, Tzu Chi University, Taiwan
    J Neurotrauma 21:479-89. 2004
    ..Their decrease following rubrospinal axotomy suggests that axonal injury may also compromise the presynaptic regulation of afferent activities onto injured cord-projection central neurons...
  18. ncbi Traumatically induced axotomy adjacent to the soma does not result in acute neuronal death
    Richard H Singleton
    Departments of Anatomy and Anesthesiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Neurosci 22:791-802. 2002
    ..Rather, some somata showed evidence of potential reorganization and repair. This study demonstrates a novel somatic response to TAI in the perisomatic domain and also provides insight into the multifaceted pathology associated with TBI...
  19. ncbi Stereological evaluation of neurons and glia in the monkey dorsal lateral geniculate nucleus following an early cerebral hemispherectomy
    Denis Boire
    School of Optometry, University of Montreal, CP 6128, Montreal, PQ, Canada, H3C 3J7
    Exp Brain Res 142:208-20. 2002
    ..The remaining neurons in the dLGN following hemispherectomy appear to be insufficient in number to be importantly implicated in the residual visual functions that have been reported in some hemispherectomized patients...
  20. ncbi [Axonal reaction precedes demyelination in experimental models of multiple sclerosis]
    E Zaprianova
    Laboratory of Neuron Functional Morphology and Physiology, RAS I P Pavlov Institute of Physiology, St Petersburg
    Morfologiia 122:54-9. 2002
    ....
  21. ncbi Delayed NGF infusion fails to reverse axotomy-induced degeneration of basal forebrain cholinergic neurons in adult p75(LNTR)-deficient mice
    C E E M Van der Zee
    Department of Cell Biology, University Medical Centre St Radboud, University of Nijmegen, The Netherlands
    Neuroscience 110:641-51. 2002
    ....
  22. ncbi Ovarian steroids reduce apoptosis induced by trophic insufficiency in nerve growth factor-differentiated PC12 cells and axotomized rat facial motoneurons
    N J MacLusky
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, 622 West 168th Street, New York, NY 10032 3702, USA
    Neuroscience 118:741-54. 2003
    ....
  23. ncbi Tumor necrosis factor-alpha triggers cell death of sensitized potassium chloride-stimulated cholinergic neurons
    Birgit Zassler
    Laboratory of Psychiatry, Department of Psychiatry, University Hospital Innsbruck, Anichstr 35, Austria
    Brain Res Mol Brain Res 113:78-85. 2003
    ..Cortical overactivation combined with an increased expression of pro-inflammatory cytokines may contribute to the cell death observed in Alzheimer's disease and ageing...
  24. ncbi Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS
    Olle Lidman
    Department of Clinical Neuroscience, Karolinska Institute, Karolinska Hospital, S 17176, Stockholm, Sweden
    J Neurosci 23:9817-23. 2003
    ....
  25. ncbi Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury
    Marc J Ruitenberg
    Graduate School for Neurosciences Amsterdam, Netherlands Institute for Brain Research, Amsterdam ZO, The Netherlands
    Neurobiol Dis 15:394-406. 2004
    ..These novel findings demonstrate that a gene therapeutic approach can be used to reverse atrophy of lesioned CNS neurons for an extended period of time...
  26. ncbi IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons
    John M Petitto
    Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610 0256, USA
    J Neuroimmunol 134:95-103. 2003
    ..Further study of IL-2's complex actions in neuronal injury may provide greater understanding of key variables that determine whether or not immunological processes in the brain are proregenerative...
  27. ncbi Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism
    Feng Quan Zhou
    Neuroscience Center, 8109 Neuroscience Research Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Sci 119:2787-96. 2006
    ..Finally, our data show that the GSK-3beta-APC pathway, previously shown to mediate developing axon growth, is also necessary for axon regeneration...
  28. ncbi Neuronal damage in hydrocephalus and its restoration by shunt insertion in experimental hydrocephalus: a study involving the neurofilament-immunostaining method
    Yuichi Aoyama
    Departments of Neurosurgery and Surgical Pathology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Neurosurg 104:332-9. 2006
    ....
  29. ncbi Traumatic axonal injury in the perisomatic domain triggers ultrarapid secondary axotomy and Wallerian degeneration
    Brian J Kelley
    Department of Anatomy and Neurobiology, Medical College of Virginia Campus at Virginia Commonwealth University, Richmond, VA 23298 0709, USA
    Exp Neurol 198:350-60. 2006
    ..Collectively, this DBI-mediated ultrarapid perisomatic axotomy and its sequelae further illustrate the varied axonal responses to trauma...
  30. ncbi Altered expression of Smad family members in injured motor neurons of rat
    Noriko Okuyama
    Department of Anatomy and Neurobiology, Osaka City University, Graduate School of Medicine, 1 4 3 Asahimachi, Abenoku, Osaka 545 8585, Japan
    Brain Res 1132:36-41. 2007
    ..Immunohistochemistry and Western blotting analysis confirmed the alterations of Smad1, 2 and 4 in injured neurons. These results suggest that the Smad signaling may be important for nerve regeneration...
  31. ncbi Effects of axotomy on telomere length, telomerase activity, and protein in activated microglia
    Barry E Flanary
    Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Neurosci Res 82:160-71. 2005
    ..We conclude that molecular mechanisms pertaining to telomere maintenance are active in the injured CNS...
  32. ncbi [Experimental studies for the improvement of facial nerve regeneration]
    O Guntinas-Lichius
    Klinik und Poliklinik Fur Hals, Nasen, Ohrenkranke, Friedrich Schiller Universitat, Lessingstrasse 2, 07740 Jena
    HNO 56:122-30. 2008
    ..Promising strategies include acceleration of nerve regeneration, forced induced use of the paralysed face, mechanical stimulation of the face, and transplantation of nerve-growth-promoting olfactory epithelium at the lesion site...
  33. ncbi Motor neuron involvement in experimental lumbar nerve root compression: a light and electron microscopic study
    Shigeru Kobayashi
    Department of Orthopedic Surgery and Rehabilitation Medicine, Fukui University School of Medicine, Fukui, Japan
    Spine (Phila Pa 1976) 32:627-34. 2007
    ..This study is to investigate the changes of lumbar motor neuron induced by mechanical nerve root compression using in vivo model...
  34. ncbi A unilateral section of the corticospinal tract at cervical level in primate does not lead to measurable cell loss in motor cortex
    T Wannier
    Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Fribourg, Switzerland
    J Neurotrauma 22:703-17. 2005
    ..The survival of the majority of CS axotomized neurons is also consistent with the observation of numerous CS axons 1 mm above the cervical hemisection...
  35. ncbi Abducens internuclear neurons depend on their target motoneurons for survival during early postnatal development
    Sara Morcuende
    Departamento de Fisiologia y Zoologia, Facultad de Biologia, Universidad de Sevilla, Avda Reina Mercedes 6, 41012 Sevilla, Spain
    Exp Neurol 195:244-56. 2005
    ..These results indicate that, during development, abducens internuclear neurons depend on their target motoneurons for survival, and that they lose this dependence with maturation...
  36. pmc Zinc accumulation after target loss: an early event in retrograde degeneration of thalamic neurons
    Peter W Land
    Department of Neurobiology and Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Eur J Neurosci 21:647-57. 2005
    ..Moreover, zinc accumulation in vivo can occur in the absence of presynaptic zinc release. Together these findings suggest that accumulation of intracellular zinc is a ubiquitous component of the cell death cascade in neurons...
  37. ncbi Retrograde dopaminergic neuron degeneration following intrastriatal proteasome inhibition
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Neurosci Lett 380:93-8. 2005
    ..These results reveal that intrastriatal proteasome inhibition sufficiently induces retrograde dopaminergic neuronal degeneration with abundant accumulation of alpha-synuclein in the SN...
  38. ncbi Spinal axonal injury induces brief downregulation of ionotropic glutamate receptors and no stripping of synapses in cord-projection central neurons
    Yueh Jan Wang
    Department of Anatomy, College of Medicine, Tzu Chi University, Hualien, Taiwan
    J Neurotrauma 21:1624-39. 2004
    ..Although this may support neurons by providing trophic influences, it nevertheless may subject them to excitotoxicity and ultimately lead to their degenerative fate...
  39. ncbi The effects of sciatic nerve axotomy on spinal motoneurons in neonatal Bax-deficient mice
    Tomonori Kinugasa
    Department of Physiology, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba City, Ibaraki 305 8575, Japan
    Neurosci Res 44:439-46. 2002
    ....
  40. ncbi Influence of the paraventricular nucleus and oxytocin on the retrograde stain of pubococcygeus muscle motoneurons in male rats
    César Antonio Pérez
    Instituto de Neuroetologia, Universidad Veracruzana, A P 566, Xalapa, Ver 91000, Mexico
    Brain Res 1041:11-8. 2005
    ..This work also shows that motoneurons distal to a transected area in the spinal cord could respond to exogenous oxytocin, an important finding for the research of spinal cord lesioned subjects...
  41. ncbi Scanning electron microscopic study of degeneration and regeneration in the olfactory epithelium after axotomy
    E E Morrison
    Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298 0551
    J Neurocytol 18:393-405. 1989
    ..Axotomy results in retrograde degeneration of mature olfactory neurons. Maximum degeneration was observed around day 4...
  42. ncbi Survival and regeneration of cutaneous and muscular afferent neurons after peripheral nerve injury in adult rats
    Dag Welin
    Department of Integrative Medical Biology, Section of Anatomy, Umea University, 901 87, Umea, Sweden
    Exp Brain Res 186:315-23. 2008
    Peripheral nerve injury induces the retrograde degeneration of dorsal root ganglion (DRG) cells, which affects predominantly the small-diameter cutaneous afferent neurons...
  43. ncbi Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy
    Anat Shirvan
    Department of Neurology and the Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, and the Sackler School of Medicine, Petach Tiqva 49100, Israel
    J Biol Chem 277:49799-807. 2002
    Damage to the optic nerve in mammals induces retrograde degeneration and apoptosis of the retinal ganglion cell (RGC) bodies. The mechanisms that mediate the response of the neuronal cells to the axonal injury are still unknown...
  44. ncbi Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2
    Ulkan Kilic
    Department of Neurology, University Hospital Zurich, Switzerland
    FASEB J 19:249-51. 2005
    ..To examine whether Epo has an impact on the retrograde degeneration of retinal ganglion cells (RGCs) following optic nerve transection in vivo, we made use of our transgenic ..
  45. ncbi Axotomy-dependent and -independent synapse elimination in organ cultures of Wld(s) mutant mouse skeletal muscle
    Simon H Parson
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds, UK
    J Neurosci Res 76:64-75. 2004
    ..Wallerian degeneration slow; Wld(s)) provides an accessible model system to understand orthograde and retrograde degeneration, because in these mice axotomy induces slow, progressive withdrawal of nerve terminals from motor ..
  46. ncbi Motor neuron death induced by axotomy in neonatal mice occurs more slowly in a mutant strain in which Wallerian degeneration is very slow
    S R Lapper
    University Laboratory of Physiology, Oxford, UK
    Eur J Neurosci 6:473-7. 1994
    ..This result extends previous work which showed that retrograde degeneration of retinal ganglion cells of adult mice was slower in C57BL/Wlds mice (V. H. Perry et al., Eur. J...
  47. pmc Mechanisms of tau-induced neurodegeneration
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA
    Acta Neuropathol 118:53-69. 2009
    ..its aggregation as neurofibrillary tangles probably impair axoplasmic flow and lead to slow progressive retrograde degeneration and loss of connectivity of the affected neurons...
  48. ncbi Transneuronal retrograde degeneration of retinal ganglion cells following restricted lesions of striate cortex in the monkey
    H Johnson
    University of Oxford, Department of Experimental Psychology, UK
    Exp Brain Res 132:269-75. 2000
    Transneuronal retrograde degeneration of retinal ganglion cells follows extensive striate cortical removal in macaque monkeys...
  49. ncbi Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice
    Shin ichi Iwata
    Department of Pharmacology, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    Synapse 51:279-86. 2004
    ..with 6-hydroxydopamine (6-OHDA) and dopaminergic neurons in the substantia nigra (SN) gradually die by retrograde degeneration. The SN were removed 2 h, 24 h, or 14 days after 6-OHDA administration...
  50. ncbi Pattern of degeneration of the spiral ganglion cell and its processes in the C57BL/6J mouse
    J A White
    Department of Otolaryngology, Head and Neck Surgery, Lahey Clinic Medical Center, 41 Mall Rd, Burlington, MA 01805, USA
    Hear Res 141:12-8. 2000
    ..These observations suggest an age-related progressive retrograde degeneration of spiral ganglion cells...
  51. ncbi Functional plasticity in extrastriate visual cortex following neonatal visual cortex damage and monocular enucleation
    K R Illig
    Department of Anatomy and Centre for Neuroscience, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    Brain Res 882:241-50. 2000
    ..and 19; VC) in cats lead to significant changes in the organization of visual pathways, including severe retrograde degeneration of retinal ganglion cells of the X/beta class...
  52. ncbi Genetic interaction between the m-AAA protease isoenzymes reveals novel roles in cerebellar degeneration
    Paola Martinelli
    Division of Biochemistry and Genetics, Istituto Neurologico C Besta, Milan, Italy
    Hum Mol Genet 18:2001-13. 2009
    ..of paraplegin (encoded by the SPG7 gene) causes hereditary spastic paraplegia, a disease characterized by retrograde degeneration of cortical motor axons...
  53. ncbi Auditory development in progressive motor neuronopathy mouse mutants
    Stefan Volkenstein
    Department of Otorhinolaryngology Head and Neck Surgery, Ruhr University of Bochum, St Elisabeth Hospital, Bleichstr 15, 44787 Bochum, Germany
    Neurosci Lett 465:45-9. 2009
    ..Studies on motoneurons show disorganization in microtubules and disturbed axonal transport, followed by retrograde degeneration of the motoneurons...
  54. ncbi Ultrastructural observations on the progress of nerve degeneration and regeneration at the suture site following vagal-hypoglossal nerve coaptation in cats
    Ming E Hu
    Department of Anatomy, Faculty of Medicine, Chung Shan Medical University, 402 Taichung, Taiwan, ROC
    Cells Tissues Organs 190:230-45. 2009
    ..Defining the mechanisms underlying the neuroplastic program could thus potentially improve the prognosis of crossover of two different peripheral nerves...
  55. ncbi Tau pathology in Alzheimer disease and other tauopathies
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Biochim Biophys Acta 1739:198-210. 2005
    ..Slowly but progressively, the affected neurons undergo a retrograde degeneration. The hyperphosphorylation of tau results both from an imbalance between the activities of tau kinases and ..
  56. ncbi Nimodipine promotes regeneration and functional recovery after intracranial facial nerve crush
    P Mattsson
    Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska Hospital, SE 171 76 Stockholm, Sweden
    J Comp Neurol 437:106-17. 2001
    ..This lesion caused complete anterograde degeneration and partial retrograde degeneration that were studied with a combination of several stereological methods...
  57. pmc Neural toxicity induced by accidental intrathecal vincristine administration
    E K Kwack
    Department of Pathology, Kyungpook National University School of Medicine, Taegu, Korea
    J Korean Med Sci 14:688-92. 1999
    ..Several neurons show intracytoplasmic eosinophilic inclusion body. Myelin loss, axonal swelling and enlargement of perivascular spaces were seen throughout the white matter of central nervous system...
  58. ncbi Quantitative analysis of cochlear sensory cells and neuronal elements in man
    H Felix
    ENT Department, University Hospital, Zurich, Switzerland
    Acta Otolaryngol Suppl 470:71-9. 1990
    ..A slow retrograde degeneration, i.e...
  59. ncbi MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system
    Massimo Filippi
    Neuroimaging Research Unit, Dept of Neurology Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
    J Neurol 252:v16-24. 2005
    ..At least part of GM pathology in MS is not secondary to retrograde degeneration of fibers traversing WM lesions...
  60. ncbi Ablation of the chemokine monocyte chemoattractant protein-1 delays retrograde neuronal degeneration, attenuates microglial activation, and alters expression of cell death molecules
    Michelle J Muessel
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7400, USA
    Brain Res Mol Brain Res 103:12-27. 2002
    ..To determine the potential role of MCP-1 in retrograde degeneration, the present study examined the effect of genetic deletion of MCP-1 (MCP-1 KO or -/-) or its high ..
  61. ncbi Different astroglial reaction between the vagal dorsal motor nucleus and nucleus ambiguus following vagal-hypoglossal nerve anastomosis in cats
    C T Lan
    Department of Anatomy, Chung Shan Medical and Dental College, No 110, Sec 1, Chien Kuo North Road, Taichung, Taiwan
    Brain Res 881:222-6. 2000
    ..Ultrastructurally, signs of retrograde degeneration occurred in some DMV and NA neurons between 3 and 25 days after VHA...
  62. ncbi Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon
    Alessia Errico
    Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
    Hum Mol Genet 13:2121-32. 2004
    Hereditary spastic paraplegia (HSP) is characterized by the specific retrograde degeneration of the longest axons in the central nervous system, the corticospinal tracts...
  63. ncbi Thalamic projections of the fusiform gyrus in man
    S Clarke
    Institut de Physiologie, Universite de Lausanne, Switzerland
    Eur J Neurosci 11:1835-8. 1999
    Previous retrograde degeneration studies have shown that human extrastriate visual cortex receives projections from the pulvinar, but their precise topographical organization remained unknown...
  64. ncbi Replacement of receptor cells in the hamster vomeronasal epithelium after nerve transection
    M Ichikawa
    Department of Anatomy and Embryology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Chem Senses 23:171-9. 1998
    ..Unilateral transection of the vomeronasal nerves in adult hamster was used to induce a retrograde degeneration of receptor cells in the vomeronasal organ...
  65. ncbi Effects of orally administered levodopa on mesencephalic dopaminergic neurons undergoing a degenerative process
    Juan E Ferrario
    Instituto de Investigaciones Farmacológicas ININFA, UBA CONICET, Buenos Aires, Argentina
    Neurosci Res 47:431-6. 2003
    ..We induced delayed retrograde degeneration of the nigrostriatal system in rats by injecting 6-hydroxydopamine (6-OHDA) intrastriatally...
  66. ncbi Moderate degeneration of nigral neurons after repeated but not after single intrastriatal injections of low doses of 6-hydroxydopamine in mice
    Franziska Richter
    Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universitat Berlin, Koserstr 20, Berlin, Germany
    Brain Res 1188:148-56. 2008
    ..of PD, a single intrastriatal injection of 6-hydroxydopamine (6-OHDA) has been reported to provoke a retrograde degeneration of nigral dopaminergic neurons and may reflect an early stage of PD...
  67. ncbi Electrophysiological findings in patients with nonarteritic anterior ischemic optic neuropathy
    Márta Janáky
    Department of Ophthalmology, Faculty of Medicine, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Koranyi rkpt 14, POB H 6701 427 Szeged, Hungary
    Clin Neurophysiol 117:1158-66. 2006
    ..To evaluate the severity of the optic nerve and retinal damage, electrophysiological tests were performed on 8 patients with NAION...
  68. ncbi Functional rehabilitation of partial cortical blindness?
    Petra Stoerig
    Institute of Experimental Psychology, Heinrich Heine University, Dusseldorf, Germany
    Restor Neurol Neurosci 26:291-303. 2008
    ..Although wide-spread antero- and retrograde degeneration follows lesions that destroy or denervate the primary visual cortex and cause partial cortical blindness, ..
  69. ncbi Evidence for retrochiasmatic tissue loss in Leber's hereditary optic neuropathy
    Valeria Barcella
    Neuroimaging Reseach Unit, Institute of Experimental Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Hum Brain Mapp 31:1900-6. 2010
    ..Such a damage to the posterior parts of the visual pathways may be due either to trans-synaptic degeneration secondary to neuroaxonal damage in the retina and optic nerve or to local mitochondrial dysfunction...
  70. pmc Axon damage and repair in multiple sclerosis
    V H Perry
    Central Nervous System Inflammation Group, School of Biological Sciences, University of Southampton, UK
    Philos Trans R Soc Lond B Biol Sci 354:1641-7. 1999
    ..Axon injury within the MS lesion will result in both Wallerian degeneration of the axon and also retrograde degeneration of the cell body...
  71. ncbi Ganglioside GM1 potentiates NGF action on axotomised medial septal cholinergic neurons
    M K Panni
    Medical Research Council Cambridge Centre for Brain Repair, Department of Anatomy, University of Cambridge, England, UK
    Brain Res 812:76-80. 1998
    Transection of the fimbria fornix leads to retrograde degeneration of axotomised septal cholinergic neurons as manifested by loss of choline acetyltransferase and p75NGFR immunoreactivity...
  72. ncbi Functional recovery of neuronal activity in rat whisker-barrel cortex sensory pathway from freezing injury after transplantation of adult bone marrow stromal cells
    Kentaro Mori
    Department of Neurosurgery, Juntendo University, Izunagaoka Hospital, Shizuoka, Japan
    J Cereb Blood Flow Metab 25:887-98. 2005
    ..The volume of the primary necrotic freezing lesion was significantly reduced (P<0.05), and secondary retrograde degeneration in the left ventral posteromedial (VPM) thalamic nucleus was diminished in the MSC-treated group...
  73. ncbi [Growth factors as neuroprotective treatment in Parkinson disease?]
    Reidun Torp
    Centre for Molecular Biology and Neuroscience CMBN, Universitetet i Oslo, Postboks 1105 Blindern, 0317 Oslo
    Tidsskr Nor Laegeforen 126:899-901. 2006
    ..The study reported here evaluates the ability of externally applied growth factors to protect the dopamine fibres in the basal ganglia in a toxin-induced animal model of the disease...
  74. ncbi Bilateral Wallerian degeneration of the medial cerebellar peduncles after ponto-mesencephalic infarction
    Clemens Fitzek
    Institute of Neuroradiology, University of Mainz, Mainz, Germany
    Eur J Radiol 49:198-203. 2004
    Three patients with acute large paramedian ponto-mesencephalic infarctions developed a bilateral retrograde degeneration of the medial cerebellar peduncles within 4 months after the insult...
  75. ncbi Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314 6399, USA
    Acta Neuropathol 109:25-31. 2005
    ..The hyperphosphorylated tau sequesters normal tau, MAP1 and MAP2, which results in breakdown of the microtubule network and, consequently, a progressive retrograde degeneration of the affected neurons and, ultimately, dementia.
  76. pmc Effects of optic nerve injury, glaucoma, and neuroprotection on the survival, structure, and function of ganglion cells in the mammalian retina
    A J Weber
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    J Physiol 586:4393-400. 2008
    ..This results in the retrograde degeneration of ganglion cells in the retina, and a progressive loss of vision...
  77. ncbi Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Neurosci Lett 401:146-9. 2006
    ..gastrointestinal tract might affect the enteric nerve endings of the vagal neurons, possibly resulting in retrograde degeneration of the DMV...
  78. ncbi Protective effects of the alpha 2-adrenoceptor antagonist, dexefaroxan, against degeneration of the basalocortical cholinergic system induced by cortical devascularization in the adult rat
    T Debeir
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, F 75013 Paris, France
    Neuroscience 115:41-53. 2002
    ..cortical devascularization that induces a loss of the cortical cholinergic terminal network and a retrograde degeneration of the cholinergic projections that originate in the nucleus basalis magnocellularis...
  79. ncbi Inner ear histopathology in "nervous Pointer dogs" with severe hearing loss
    Angélique G Coppens
    Department of Anatomy and Embryology, Laboratory of Veterinary Anatomy, Faculty of Medicine, Free University of Brussels, 808 Lennik Street, B 1070 Brussels, Belgium
    Hear Res 200:51-62. 2005
    ..This possible animal model might provide information about progressive juvenile hereditary deafness and neuronal retrograde degeneration investigations in human.
  80. ncbi Bone marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord
    P G Popovich
    Department of Molecular Virology, Immunology and Medica Genetics, The Ohio State University College of Medicine and Public Health, Columbus, USA
    J Neuropathol Exp Neurol 60:676-85. 2001
    ..If functional differences exist between CNS macrophage subsets, differences in the time-dependent accumulation and distribution of these cell types could differentially influence the survival of surrounding neurons and glia...
  81. pmc Hereditary neuropathy with liability to pressure palsy: fulminant development with axonal loss during military training
    S H Horowitz
    Division of Neurology, M 178, University of Missouri School of Medicine, Columbia 65212, USA
    J Neurol Neurosurg Psychiatry 75:1629-31. 2004
    ..Genetic testing revealed PMP-22 gene deletion. This case report demonstrates that HNPP can present with rapidly progressive peripheral nerve dysfunction and electrophysiological evidence of focal axonal loss...
  82. ncbi Potential role of microRNA: identification and functional analysis of microRNA in corticospinal tract after unilateral lesions of the medullary pyramid
    Ning Hao
    Department of Anatomy and Neurobiology, The Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China
    Neurosci Lett 564:37-42. 2014
    ..Proximal end is connected to the neuron cell body, whereas retrograde degeneration is very slight with the possibility of regeneration...
  83. ncbi Expression of neuronal isoform of nitric oxide synthase in spinal neurons of neonatal rats after sciatic nerve transection
    F Rogerio
    Department of Physiology and Biophysics, State University of Campinas, UNICAMP, 13083 970, SP, Campinas, Brazil
    Neurosci Lett 307:61-4. 2001
    ..These results are at variance with previous studies which showed correlation between motoneuron loss after axotomy and number of NADPH-diaphorase positive motoneurons after sciatic transection...
  84. ncbi Early immunohistochemical detection of axonal damage and glial activation in extremely immature brains with periventricular leukomalacia
    A Hirayama
    Department of Clinical Laboratory, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan
    Clin Neuropathol 20:87-91. 2001
    ..Therefore, the perinatal management to maintain an appropriate cerebral circulation and oxygenation may be very important...
  85. ncbi In vivo imaging of retinal ganglion cell axons within the nerve fiber layer
    Akiyasu Kanamori
    Maisonneuve Rosemont Hospital Research Center and Department of Ophthalmology, University of Montreal, Montreal, Canada
    Invest Ophthalmol Vis Sci 51:2011-8. 2010
    ..Intravitreal CMFDA can be used to longitudinally monitor RGC axons within the RNFL in vivo. Imaging the disappearance of retrograde-labeled RGC somas and axons indicates that axonal and somal degeneration occur in parallel after axotomy...
  86. ncbi [Pathogenesis of spinal cord injuries and mechanisms of repair induced by olfactory ensheathing cells]
    Lucía Botero
    Facultad de Medicina Veterinaria y de Zootecnia, Universidad Nacional de Colombia, Bogota DC, Colombia
    Rev Neurol 56:521-31. 2013
    ....
  87. pmc Mapping anterograde and retrograde degeneration after stroke
    J C Baron
    J Neurol Neurosurg Psychiatry 76:159-60. 2005
  88. ncbi [Mechanisms of development of secondary axonal failure in diffuse and local demyelinating neuropathies]
    Iu A Merkulov
    Zh Nevrol Psikhiatr Im S S Korsakova 107:37-41. 2007
    ....
  89. ncbi Axonal loss in murine peripheral nerves following exposure to recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge
    David S Margolis
    Department of Orthopaedic Surgery, University of Arizona, 1609 North Warren Avenue, Room 108, Tucson, AZ 85719, USA
    J Bone Joint Surg Am 95:611-9. 2013
    ..Little is known about changes that result when rhBMP-2 is used in the vicinity of peripheral nerves. The purpose of this study is to characterize changes in peripheral nerves following exposure to rhBMP-2-soaked collagen sponges...
  90. ncbi A rapid, easy technique for defining detailed anatomical orientation in pre-deparaffinized tissue sections
    A Mekada
    Department of Ophthalmology, Shiga University of Medical Science, Japan
    J Neurosci Methods 82:203-5. 1998
    During our previous histochemical studies on changes in anterograde and retrograde degeneration following optic nerve transection in rats, it was necessary to make brain sections in which various bilateral components of the visual system ..
  91. ncbi β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau
    Amalia Tsolakidou
    Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    Alzheimers Dement 9:386-91. 2013
    ..Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) activity determines the rate of APP cleavage and is therefore the main driver of amyloid β production, which is a pathological hallmark of Alzheimer's disease (AD)...
  92. ncbi Regulation of actomyosin contractility by PI3K in sensory axons
    Irina Orlova
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Dev Neurobiol 67:1843-51. 2007
    ..These data provide insights into the regulation of the neuronal cytoskeleton by PI3K and are consistent with the notion that decreased levels of PI3K activity mediate axon retraction and growth cone collapse in response to semaphorin 3A...
  93. ncbi Activation of c-Jun and ATF-2 in primate motor cranial nerve nuclei is not associated with apoptosis following axotomy
    Geoffrey P Colby
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, Black Building Room 1204, 630 West 168th Street, New York, NY 10032, USA
    Exp Neurol 194:57-65. 2005
    ..This report serves as a basic inquiry into the neuronal response to cranial nerve injury in primates...
  94. ncbi Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease
    Ulrika Nordström
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, BMC B11, 221 84 Lund, Sweden
    Neurobiol Dis 73:70-82. 2015
    ..Our findings support a progressive retrograde degeneration of En1(+/-) nigrostriatal neurons, akin to what is suggested to occur in PD...
  95. ncbi [Number changes and axonal sprouting of neuropeptide Y interneurons in the hippocampus of pilocarpine-induced rats]
    Wu Zhiguo
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 34:93-8. 2009
    ..To investigate the role of neuropeptide Y(NPY) positive interneurons in the generation and compensation of temporal lobe epilepsy...
  96. pmc Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease
    Heike Bommel
    Institute of Clinical Neurobiology, University of Wurzburg, 97080 Wurzburg, Germany
    J Cell Biol 159:563-9. 2002
    ..Thus, the pmn gene mutation provides the first genetic evidence that alterations in tubulin assembly lead to retrograde degeneration of motor axons, ultimately resulting in motoneuron cell death.
  97. ncbi Forearm mixed nerve conduction velocity: questionable role in the evaluation of retrograde axonal atrophy in carpal tunnel syndrome
    Ming Hong Chang
    Taichung Veterans General Hospital, Taiwan
    J Clin Neurophysiol 20:196-200. 2003
    ..In the disease state, Fmix possibly represents the conduction velocity of the palmar cutaneous branch...
  98. ncbi Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine
    A Petersen
    Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Sweden
    Eur J Neurosci 14:1425-35. 2001
    ..We conclude that striatal neurons of R6 mice develop resistance to DA-induced toxicity with age...
  99. ncbi [Effect of stimulation of the facial nucleus on discharge of respiratory neurons in the pre-Bözinger complex and its neurotransmitter mechanism in rats]
    Heng Xiu Yan
    Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Sheng Li Xue Bao 56:665-70. 2004
    ..In 12 rats with retrograde degeneration of the facial motor neurons, 116 RNs in the PBC ipsilateral to the facial nerve sectioned were ..
  100. ncbi Neurobiology of glaucomatous optic neuropathy: diverse cellular events in neurodegeneration and neuroprotection
    Martin B Wax
    Pharmacia Corporation, St Louis, MO 63138, USA
    Mol Neurobiol 26:45-55. 2002
    ....
  101. ncbi [What is a peripheral neuropathy?]
    Laurent Magy
    Service de Neurologie, CHRU Dupuytren, 87042 Limoges Cedex, France
    Rev Prat 58:1873-7, 1880-1. 2008
    ..In a limited number of cases, nerve biopsy is still a very useful tool to determinate the mechanism of peripheral neuropathy and to guide the treatment...

Research Grants34

  1. The shape and circuitry of neurons in the retina.
    MARGARET MACNEIL; Fiscal Year: 2012
    ..Our preliminary results suggest that transneuronal retrograde degeneration of 2 ganglion cells after early lesions of primary visual cortex alters the composition of the INL in a ..
  2. EXCITOTOXIC MECHANISMS IN POST TRAUMATIC NEURONAL DEATH
    Douglas Ross; Fiscal Year: 1992
    ..populations distant to sites of direct cortical injury, 1) specific thalamic relay nuclei which undergo retrograde degeneration following cortical injury, 2) hippocampal pyramidal neurons in the CA1 region of Ammon's horn which ..
  3. IMPLANTED ELECTRODE-ARRAYS QUANTIFY NERVE REGENERATION
    Christian Krarup; Fiscal Year: 1990
    ..The method has the advantage that different phases of the regenerative process, (such as retrograde degeneration, delays in regeneration, the rate of elongation, and the level of maturation), can be differentiated...
  4. HUMAN MODEL OF VESTIBULAR DEAFFERENTATION
    Akira Ishiyama; Fiscal Year: 2001
    ..2) Reciprocally, is the vestibular nerve dependent on the vestibular hair cells for survival? 3) Does retrograde degeneration occur in the presence of intact afferent dendrites? 4) Is there a subtype of calretinin immunoreactive ..
  5. REORGANIZATION AFTER BRAIN INJURY
    JAIME VILLABLANCA; Fiscal Year: 1990
    ..hemisphere which reinnervate deafferented targes (tritiated amino acids autoradiography); b) amount of retrograde degeneration and atrophy in thalamic- brain stem nuclei (computerized morphometrics); c) changes in metabolic activity ..
  6. NEUROTROPHIC FACTORS AND CNS TRANSPLANTATION
    GREGORY HELM; Fiscal Year: 1999
    ..neurosurgery involve the application of neurotrophic factors to rescue axotomized neurons from retrograde degeneration, neuronal transplantation to replace lost neural populations, and the use of antibodies directed against ..
  7. MOTOR NEURON DISEASES AND TROPHIC THERAPIES
    Donald Price; Fiscal Year: 2000
    ..models associated with dysfunction/death of motor neurons are described including: axotomy-induced retrograde degeneration paradigms of somatic motor neurons, neurons of Onuf's nucleus, and corticospinal neurons; hereditary ..
  8. MECHANISMS OF NEURONAL APOPTOSIS IN VIVO
    Lee Martin; Fiscal Year: 2009
    Neurons in the nervous system undergo retrograde degeneration in neurodegenerative diseases and after acute neurological insults...
  9. CELLULAR TOXICOLOGY OF THE DOPAMINE NEURON
    Juan Sanchez Ramos; Fiscal Year: 1990
    ..in culture, 2) to test the hypothesis that MPP+ acts primarily on neuronal fibers, with subsequent retrograde degeneration of the neuron, 3) to test the hypothesis that oxyradicals mediate MPP+ induced destruction of dopamine ..
  10. HISTOCHEMICAL STUDIES OF HUNTINGTON'S DISEASE BRAIN
    Neil Kowall; Fiscal Year: 1992
    ..Nigrostriatal and corticostriatal projection systems will be studied for evidence of retrograde degeneration. Defining the pathological basis of HD will permit the accurate assessment of animal models, improve the ..
  11. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
    ....
  12. Immunodeficiency and Neuronal Function
    JOHN PETITTO; Fiscal Year: 2008
    ....
  13. Nerve Growth Factor-Mechanisms for Signal Transduction
    William Mobley; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  14. MBRS SCORE Program at the Univ of Texas-Brownsville
    LUIS COLOM; Fiscal Year: 2007
    ..Furthermore, the success of this application will contribute to the development of internal collaborations and the necessary scientific environment to develop successful R01 applications in the near future. ..
  15. Training in Translational Develomental Neuroscience
    Paul Fisher; Fiscal Year: 2008
    ..The program in "Translational Developmental Neuroscience" will produce child neurologist-neuroscientists that can successfully translate developmental neuroscience insights into new treatments. ..
  16. AMYGDALOID FUNCTION IN FEAR CONDITIONING
    Stephen Maren; Fiscal Year: 2009
    ..The outcome of these experiments will have an important impact on current conceptions of both amygdaloid function and on clinical disorders of fear that depend on emotional learning and memory. ..
  17. Hereditary Spastic Paraplegia due to SPG3A/atlastin mutation
    John Fink; Fiscal Year: 2009
    ....
  18. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2010
    ..E2 in relapsing, chronic, and spontaneous models of EAE. These studies will clearly establish E2- and EE- dependent pathways of EAE protection and therapy that may have direct relevance for future clinical trials in MS patients. ..
  19. Structure-Function of the Retina With Neuroprotection
    Arthur Weber; Fiscal Year: 2009
    ....
  20. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2005
    ..These proposed studies will provide new and definitive insights into the biological importance and function of TCR-reactive T ceils in preventing and treating spontaneous and induced EAE, and will guide further human studies. ..
  21. VISUAL THALAMIC RETICULAR ACTIVATION IN AWAKE ANIMALS
    VICENTE MONTERO; Fiscal Year: 2001
    ..The results will advance our understanding of the role of TRN in the awake behaving animal, in particular with respect to its role in modulating thalamocortical transmission and in subcortical mechanisms of selective attention. ..
  22. GENDER INFLUENCES IMMUNOREGULATION IN R EAE
    Halina Offner; Fiscal Year: 2001
    ....
  23. HEREDITARY SPASTIC PARAPLEGIA--CLINICAL, HISTOCHEMICAL,
    John Fink; Fiscal Year: 2001
    ..abstract_text> ..
  24. Mechanisms of Basal Forebrain Neurodegeneration
    LUIS COLOM; Fiscal Year: 2004
    ..Data from this work may contribute to the development of specific therapies designed to decrease neuronal dysfunction and vulnerability in AD. Furthermore, this work will contribute to our understanding of basal forebrain physiology. ..
  25. MAPPING DS RELATED CNS PHENOTYPES
    William Mobley; Fiscal Year: 2002
    ....
  26. Neuroimmunology of IL-15
    JOHN PETITTO; Fiscal Year: 2004
    ..abstract_text> ..
  27. Disrupted Transport of NGF-TrKA Signaling in Mouse Models of Down Syndrome
    William C Mobley; Fiscal Year: 2010
    ..These studies are an important first step in clarifying the pathogenesis of BFCN neurodegeneration in the setting of increased APR expression and may motivate novel treatment strategies. ..
  28. International Symposium for Hereditary Spastic Paraplegia
    John Fink; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. HEAT SHOCK PROTEINS AND THEIR ANTIBODIES IN GLAUCOMA
    Martin Wax; Fiscal Year: 2002
    ..Finally, they will utilize a yeast "two-hydrid" system to identify genes encoding potentially novel proteins that bind and interact with retinal heat shock proteins. ..
  30. IL-2 GENE DELETION: NEURODEVELOPMENT AND BEHAVIOR
    JOHN PETITTO; Fiscal Year: 2002
    ..We believe that the proposed research is timely and will lay an essential foundation on which to build in future studies. ..
  31. AMYGDALOID FUNCTION IN FEAR CONDITIONING
    Stephen Maren; Fiscal Year: 2002
    ..The outcome of these experiments will have an important impact on current conceptions of both amygdaloid function and emotional learning and memory. ..
  32. NGF SIGNALING IN MODELS OF AGE RELATED NEURODEGENERATION
    William Mobley; Fiscal Year: 2002
    ..Evidence that abnormal NGF signaling is responsible for BFCN degeneration in models of AD and DS will give important new insights into pathogenesis and may suggest novel approaches to prevent or reverse dementia in these patients. ..