multiple organ failure

Summary

Summary: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.

Top Publications

  1. ncbi The epidemiology of sepsis in the United States from 1979 through 2000
    Greg S Martin
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
    N Engl J Med 348:1546-54. 2003
  2. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003
  3. pmc Immunosuppression in patients who die of sepsis and multiple organ failure
    Jonathan S Boomer
    Department of Medicine, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    JAMA 306:2594-605. 2011
  4. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
  5. ncbi Heat stroke
    Abderrezak Bouchama
    Medical and Surgical Intensive Care Unit and Comparative Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    N Engl J Med 346:1978-88. 2002
  6. ncbi Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 27:1230-51. 1999
  7. ncbi Serial evaluation of the SOFA score to predict outcome in critically ill patients
    F L Ferreira
    Department of Intensive Care, Erasme University Hospital, Route de Lennik, 808, B 1070 Brussels, Belgium
    JAMA 286:1754-8. 2001
  8. ncbi The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Blood 101:3765-77. 2003
  9. ncbi Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Crit Care Med 26:1793-800. 1998
  10. ncbi Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS
    L Brochard
    Medical Intensive Care Unit, Henri Mondor Hospital, Assistance Publique Hopitaux de Paris, Université Paris XII and INSERM U 492, Creteil, France
    Am J Respir Crit Care Med 158:1831-8. 1998

Detail Information

Publications315 found, 100 shown here

  1. ncbi The epidemiology of sepsis in the United States from 1979 through 2000
    Greg S Martin
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
    N Engl J Med 348:1546-54. 2003
    ..We investigated the epidemiology of sepsis in the United States, with specific examination of race and sex, causative organisms, the disposition of patients, and the incidence and outcome...
  2. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 31:1250-6. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  3. pmc Immunosuppression in patients who die of sepsis and multiple organ failure
    Jonathan S Boomer
    Department of Medicine, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    JAMA 306:2594-605. 2011
    ..Whether this hyperinflammatory phase is followed by immunosuppression is controversial. Animal studies suggest that multiple immune defects occur in sepsis, but data from humans remain conflicting...
  4. ncbi 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    Mitchell M Levy
    Rhode Island Hospital, 593 Eddy Street, MICU Main 7, Providence RI 02903, USA
    Intensive Care Med 29:530-8. 2003
    ..Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect our current understanding of the pathophysiology of these syndromes...
  5. ncbi Heat stroke
    Abderrezak Bouchama
    Medical and Surgical Intensive Care Unit and Comparative Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    N Engl J Med 346:1978-88. 2002
  6. ncbi Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
    R S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Crit Care Med 27:1230-51. 1999
    ..The purpose of this study was to determine whether apoptosis is a major mechanism of cell death in patients with sepsis. The activities of caspase-3 and the antiapoptotic protein, BCL-2, were investigated also...
  7. ncbi Serial evaluation of the SOFA score to predict outcome in critically ill patients
    F L Ferreira
    Department of Intensive Care, Erasme University Hospital, Route de Lennik, 808, B 1070 Brussels, Belgium
    JAMA 286:1754-8. 2001
    ..Evaluation of trends in organ dysfunction in critically ill patients may help predict outcome...
  8. ncbi The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Blood 101:3765-77. 2003
    ....
  9. ncbi Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Crit Care Med 26:1793-800. 1998
    ..To evaluate the use of the Sequential Organ Failure Assessment (SOFA) score in assessing the incidence and severity of organ dysfunction in critically ill patients...
  10. ncbi Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS
    L Brochard
    Medical Intensive Care Unit, Henri Mondor Hospital, Assistance Publique Hopitaux de Paris, Université Paris XII and INSERM U 492, Creteil, France
    Am J Respir Crit Care Med 158:1831-8. 1998
    ..3 d, p = 0.85), the incidence of pneumothorax (14% versus 12%, p = 0. 78), or the secondary occurrence of multiple organ failure (41% versus 41%, p = 1)...
  11. ncbi Neutrophils in development of multiple organ failure in sepsis
    K A Brown
    Division of Medical Education, King s College School of Medicine, London, UK
    Lancet 368:157-69. 2006
    b>Multiple organ failure is a major threat to the survival of patients with sepsis and systemic inflammation. In the UK and in the USA, mortality rates are currently comparable with and projected to exceed those from myocardial infarction...
  12. pmc Brazilian Sepsis Epidemiological Study (BASES study)
    Eliezer Silva
    Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Crit Care 8:R251-60. 2004
    ..This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome..
  13. ncbi Is worsening multiple organ failure the cause of death in patients with severe sepsis?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 39:1050-5. 2011
    ..We used the INDEPTH (International Integrated Database for the Evaluation of Severe Sepsis and Drotrecogin alfa activated) database to investigate the reported cause of death in patients with severe sepsis...
  14. ncbi Current theories on the pathophysiology of multiple organ failure after trauma
    Takeshi Tsukamoto
    Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Injury 41:21-6. 2010
    Despite the enormous efforts to elucidate the mechanisms of the development of multiple organ failure (MOF) following trauma, MOF following trauma is still a leading cause of late post-injury death and morbidity...
  15. ncbi Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial
    B L Warren
    Brown University School of Medicine, Infectious Disease Division, Memorial Hospital of Rhode Island, 111 Brewster St, Pawtucket, RI 02860, USA
    JAMA 286:1869-78. 2001
    ..There was some evidence to suggest a treatment benefit of antithrombin III in the subgroup of patients not receiving concomitant heparin...
  16. pmc Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness
    Jessica A Clark
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Shock 28:384-93. 2007
    ....
  17. ncbi C-reactive protein levels correlate with mortality and organ failure in critically ill patients
    Suzana M A Lobo
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Chest 123:2043-9. 2003
    ..This study assessed the association between early serum CRP concentrations and the development of organ failure and mortality in ICU patients...
  18. ncbi Effect of blood products transfusion on the development of postinjury multiple organ failure
    Jeffrey L Johnson
    Department of Surgery, University of Colorado Denver, USA
    Arch Surg 145:973-7. 2010
    Transfusion of fresh frozen plasma (FFP) and platelets is independently associated with the development of multiple organ failure (MOF) in critically injured patients.
  19. pmc Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction
    Gian Paolo Castelli
    Intensive Care, Anesthesiology and Pain Relief Unit, C Poma Hospital, Mantova, Italy
    Crit Care 8:R234-42. 2004
    ..We hypothesised that PCT and CRP concentrations are different in patients with infection or with no infection at a similar severity of organ dysfunction or of systemic inflammatory response...
  20. ncbi Influence of sex and age on mods and cytokines after multiple injuries
    Michael Frink
    Trauma Department, Hannover Medical School, 30625 Hannover, Germany
    Shock 27:151-6. 2007
    ..This suggestion is based on the fact that such salutary effects were apparent predominantly in premenopausal females...
  21. ncbi Multiple organ failure in sepsis: prognosis and role of systemic inflammatory response
    Thierry Gustot
    Department of Gastroenterology and Hepato Pancreatology, Erasme Hospital, Belgium
    Curr Opin Crit Care 17:153-9. 2011
    ..To describe the pathogenesis and emphasize prognosis of systemic inflammatory response during severe infection...
  22. ncbi Comparison of procalcitonin and C-reactive protein as markers of sepsis
    Aldo Luzzani
    Institute of Anesthesiology and Intensive Care, University Hospital, Verona, Italy
    Crit Care Med 31:1737-41. 2003
    ..To compare the clinical informative value of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in the detection of infection and sepsis and in the assessment of severity of sepsis...
  23. ncbi Post-injury multiple organ failure: the role of the gut
    H T Hassoun
    Department of Surgery, University of Texas-Houston Medical School, 77030, USA
    Shock 15:1-10. 2001
    Despite intensive investigation, the pathogenesis of post-injury multiple organ failure (MOF) remains elusive. Laboratory and clinical research strongly suggests that the gastrointestinal tract (i.e...
  24. ncbi Clinical characteristics and outcomes of obstetric patients requiring ICU admission
    Daniela N Vasquez
    Intensive Care Unit, Hospital Interzonal General de Agudos Gral, San Martin, 1 y 70, 1900 La Plata, Buenos Aires, Argentina
    Chest 131:718-24. 2007
    ..To review a series of critically ill obstetric patients admitted to our ICU to assess the spectrum of disease, required interventions, and fetal/maternal mortality, and to identify conditions associated with maternal death...
  25. ncbi Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality
    R J Nijveldt
    Department of Surgery, Institute for Cardiovascular Research VU VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Clin Nutr 22:23-30. 2003
    ..In critically ill patients, we investigated the relation between indicators of renal and hepatic dysfunction and plasma ADMA concentration, and tested the association between ADMA concentration and outcome...
  26. ncbi Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome
    Gregory A Watson
    Division of General Surgery and Trauma, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Trauma 67:221-7; discussion 228-30. 2009
    Blood transfusion is known to be an independent risk factor for mortality, multiple organ failure (MOF), acute respiratory distress syndrome (ARDS), and nosocomial infection after injury...
  27. ncbi Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
    Andres Esteban
    Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
    JAMA 287:345-55. 2002
    ..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
  28. ncbi Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis
    Renu Sharma
    Department of Pediatrics, University of Florida at Jacksonville, Jacksonville, FL 32209, USA
    J Pediatr Surg 42:454-61. 2007
    Failure of the gut barrier and endotoxemia have been implicated in sepsis and multiple organ failure (MOF) syndromes in adults...
  29. ncbi Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute of Biomedical Research and Department of Medicine, University College London, London, UK
    Lancet 364:545-8. 2004
    ..We propose that, first, multiple organ failure induced by critical illness is primarily a functional, rather than structural, abnormality...
  30. ncbi Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure
    Hirokazu Ueno
    Department of Emergency and Critical Care Medicine, Chiba University School of Medicine, Japan
    Crit Care Med 30:2242-8. 2002
    Until recently, attention has been directed to disseminated intravascular coagulation as a cause of multiple organ failure (MOF)...
  31. ncbi Sepsis mortality prediction based on predisposition, infection and response
    Rui P Moreno
    Unidade de Cuidados Intensivos Polivalente, Hospital de St António dos Capuchos, Centro Hospitalar de Lisboa Central E P E, 1150 069 Lisbon, Portugal
    Intensive Care Med 34:496-504. 2008
    ....
  32. ncbi Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats
    Jeng Yuan Wu
    Division of Thoracic Surgery, Taichung Tzu Chi General Hospital, Taichung, Taiwan
    J Pineal Res 45:106-16. 2008
    ..Some studies show that an overproduction of nitric oxide (NO) leads to the refractory hypotension and multiple organ failure, while other studies suggest that free radicals, e.g...
  33. pmc Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation
    Renee R Hukkanen
    University of Washington, Department of Comparative Medicine, Seattle, Washington 98195 7190, USA
    Toxicol Pathol 37:799-804. 2009
    ..Experimental manipulation of NHP models may be complicated by SIRS and accompanying rapid clinical decompensation. Such adverse events may compromise toxicological studies and should be avoided when possible...
  34. ncbi Surgical decompression for abdominal compartment syndrome in severe acute pancreatitis
    Panu Mentula
    Department of Gastroenterologic and General Surgery, Helsinki University Central Hospital, PO Box 340, 00029 HUS, Helsinki, Finland
    Arch Surg 145:764-9. 2010
    ..In patients with severe acute pancreatitis and abdominal compartment syndrome, establishment of the indications and optimal time for surgical decompression may avoid exacerbation of multiple-organ dysfunction syndrome...
  35. pmc Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis
    Paulo S Martins
    Division of Infectious Diseases, Escola Paulista de Medicina, Federal University of Sao Paulo, Brazil
    Crit Care 12:R25. 2008
    ..The aims of this study were to evaluate cell activation in the context of sepsis and its correlation with organ dysfunction...
  36. pmc Systemic versus localized coagulation activation contributing to organ failure in critically ill patients
    Marcel Levi
    Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Semin Immunopathol 34:167-79. 2012
    ..considerable consequences, for example in the pathogenesis of microvascular failure and subsequent multiple organ failure, as a result of severe infection and the associated systemic inflammatory response...
  37. ncbi Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings?
    Edwin A Deitch
    Department of Surgery, New Jersey Medical School, Newark, NJ 07103, USA
    Surgery 131:241-4. 2002
  38. ncbi Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
    Madhav Bhatia
    Department of Pharmacology, National University of Singapore, Singapore
    J Pathol 202:145-56. 2004
    ..It is reasonable to speculate that elucidation of the key mediators in ARDS coupled with the discovery of specific inhibitors would make it possible to develop clinically effective anti-inflammatory therapy...
  39. ncbi Multiple organ failure in patients with cardiogenic shock is associated with high plasma levels of interleukin-6
    Alexander Geppert
    Department of Cardiology, Intensive Care Unit, University of Vienna, Austria
    Crit Care Med 30:1987-94. 2002
    In patients with septic shock, multiple organ failure (MOF) is associated with high levels of interleukin-6 (IL-6)...
  40. ncbi Gender differences in human sepsis
    J Schroder
    Department of General and Thoracic Surgery, University of Kiel, Germany
    Arch Surg 133:1200-5. 1998
    ..In animal studies, gender differences were related to hormonal and immunologic changes that were associated with an increased susceptibility to sepsis in males...
  41. ncbi Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure
    David Brealey
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute of Biomedical Research, Department of Medicine, University College London, London WC1E 6BT, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 286:R491-7. 2004
    ..Despite the well-recognized limitations of laboratory models, we found clear parallels between this long-term model and human disease characteristics that will facilitate future translational research...
  42. ncbi Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level
    Mitchell P Fink
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 616 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care Clin 21:177-96. 2005
    ....
  43. ncbi A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome
    Anna J Dare
    Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1142, New Zealand
    Free Radic Biol Med 47:1517-25. 2009
    ..We expect that mitochondrial therapies will have an increasingly important role in the management of sepsis and MODS. Clinical trials are now required...
  44. ncbi Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome
    J C Marshall
    Department of Surgery, University Health Network, University of Toronto, Ontario, Canada
    Crit Care Med 29:S99-106. 2001
    ....
  45. pmc Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study
    Jesus Blanco
    Critical Care Department, Nuevo Hospital Universitario Río Hortega, Calle Dulzaina s n, 47012 Valladolid, Spain
    Crit Care 12:R158. 2008
    ..We present the first extensive dataset on the epidemiology of severe sepsis treated in ICUs in Spain...
  46. ncbi Severe falciparum malaria: an important cause of multiple organ failure in Indian intensive care unit patients
    Anand Krishnan
    Department of Medicine, Seth G S Medical College, Parel, Mumbai, India
    Crit Care Med 31:2278-84. 2003
    ..To study the incidence and severity of multiple organ dysfunction in severe falciparum malaria...
  47. ncbi MOF, MODS, and SIRS: what is in a name or an acronym?
    Arthur E Baue
    Department of Surgery, Yale University School of Medicine, New Haven, CT, USA
    Shock 26:438-49. 2006
    The most prominent contributions to multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome are described in this article...
  48. pmc Intensity of renal support in critically ill patients with acute kidney injury
    Paul M Palevsky
    N Engl J Med 359:7-20. 2008
    ..The optimal intensity of renal-replacement therapy in critically ill patients with acute kidney injury is controversial...
  49. ncbi Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients
    Alenka Spindler-Vesel
    University Medical Centre, Ljubljana, Slovenia
    JPEN J Parenter Enteral Nutr 31:119-26. 2007
    ....
  50. pmc The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study
    Annette M Esper
    Division of Pulmonary, Emory University, Atlanta, Georgia 30322, USA
    Crit Care 13:R18. 2009
    ..Previous studies reported that people with DM and severe sepsis are less likely to develop acute lung injury (ALI). We sought to determine whether organ dysfunction differed between people with and without DM and sepsis...
  51. ncbi Prognostic factors in obstetric patients admitted to an Indian intensive care unit
    Dilip R Karnad
    Medical Neurology Neurosurgery Intensive Care Unit, Seth G S Medical College and King Edward VII Memorial Hospital, Parel, Mumbai, India
    Crit Care Med 32:1294-9. 2004
    ..We studied the diseases requiring intensive care and prognostic factors in obstetric patients...
  52. pmc Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
    Benoit Vallet
    Department of Anesthesiology and Intensive Care, University Hospital, Lille, France
    Crit Care 7:130-8. 2003
    ..Now, direct and indirect evidence for endothelial cell alteration in humans during septic shock is emerging. The present review details recently published literature on this rapidly evolving topic...
  53. ncbi Multiple organ failure still a major cause of morbidity but not mortality in blunt multiple trauma
    D Nast-Kolb
    Department of Trauma Surgery, , Essen, Germany
    J Trauma 51:835-41; discussion 841-2. 2001
    BACKGROUND: Multiple organ failure (OF/MOF) was found to be the major complication after blunt multiple trauma during the last 25 years and was correlated with a high mortality rate...
  54. ncbi A randomized clinical trial of hydroxymethylglutaryl- coenzyme a reductase inhibition for acute lung injury (The HARP Study)
    Thelma R Craig
    Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, UK
    Am J Respir Crit Care Med 183:620-6. 2011
    ..There is no effective pharmacological treatment for acute lung injury (ALI). Statins are a potential new therapy because they modify many of the underlying processes important in ALI...
  55. ncbi Increased mortality in septic shock with the 4G/4G genotype of plasminogen activator inhibitor 1 in patients of white descent
    Gloria Garcia-Segarra
    Medical Intensive Care Unit, Hospital Clinic, IDIBAPS, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain
    Intensive Care Med 33:1354-62. 2007
    ..To evaluate the effect of the 4G/5G PAI-1 gene polymorphism on the development of organ failure and outcome in critically ill patients with septic syndromes...
  56. ncbi Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study
    Attila Olah
    Department of Surgery, Petz Aladar Teaching Hospital, Gyor, Hungary
    Hepatogastroenterology 54:590-4. 2007
    ..In a prospective, randomized, double-blinded study the role of "Synbiotic 2000", a new synbiotic composition with high colony forming unit (CFU) was evaluated in the treatment of severe acute pancreatitis...
  57. pmc Occult hypoperfusion is associated with increased mortality in hemodynamically stable, high-risk, surgical patients
    André Meregalli
    Central Intensive Care Unit of the Santa Casa Hospital, Porto Alegre, Brazil
    Crit Care 8:R60-5. 2004
    ..Our aim was to examine whether serial blood lactate levels could be used as predictors of outcome...
  58. ncbi Systemic inflammatory response secondary to abdominal compartment syndrome: stage for multiple organ failure
    Joao B Rezende-Neto
    Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Trauma 53:1121-8. 2002
    The abdominal compartment syndrome (ACS) has been implicated in the pathogenesis of postinjury multiple organ failure. The ACS is defined as intra-abdominal hypertension causing adverse physiologic response...
  59. ncbi Critically Ill patients with 2009 influenza A(H1N1) in Mexico
    Guillermo Dominguez-Cherit
    Division of Pulmonary and Critical Care Dr Domínguez Cherit, Hospital Epidemiology Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    JAMA 302:1880-7. 2009
    ..In March 2009, novel 2009 influenza A(H1N1) was first reported in the southwestern United States and Mexico. The population and health care system in Mexico City experienced the first and greatest early burden of critical illness...
  60. pmc Sepsis, multiple organ failure, and death due to Pandoraea pnomenusa infection after lung transplantation
    Martin E Stryjewski
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Clin Microbiol 41:2255-7. 2003
    ..Heretofore considered soil bacteria and colonizers that infect patients with chronic lung diseases, Pandoraea species can produce severe infections...
  61. ncbi Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats
    Xiao Jing Lin
    Rehabilitation Department of Spinal Cord Injury, General Hospital Jinan Military, Shandong, China
    J Pineal Res 50:436-44. 2011
    ..Thus, melatonin could be a novel agent for the treatment of heatstroke animals or patients in the early stage...
  62. pmc Antiplatelet therapy is associated with decreased transfusion-associated risk of lung dysfunction, multiple organ failure, and mortality in trauma patients
    Jeffrey N Harr
    Department of Surgery, University of Colorado Denver, Aurora, CO 80045, USA
    Crit Care Med 41:399-404. 2013
    To determine whether prehospital antiplatelet therapy was associated with reduced incidence of acute lung dysfunction, multiple organ failure, and mortality in blunt trauma patients.
  63. pmc Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1
    You Ying Chau
    Medical Research Council Human Genetics Unit and the Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
    PLoS Genet 7:e1002404. 2011
    ....
  64. pmc Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure
    Trung C Nguyen
    Section of Critical Care, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Crit Care Med 36:2878-87. 2008
    Thrombocytopenia-associated multiple organ failure (TAMOF) is a poorly understood syndrome in critically ill children...
  65. ncbi The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection
    Nathan Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
    Ann Emerg Med 48:583-90, 590.e1. 2006
    ....
  66. ncbi Melatonin ameliorates hemorrhagic shock-induced organ damage in rats
    Fwu Lin Yang
    School of Medicine, Tzu Chi University, Hualien, Taiwan
    J Surg Res 167:e315-21. 2011
    ..Melatonin can attenuate organ damage with its anti-inflammation effects. The present study was designed to investigate the effects of melatonin on the physiopathology and cytokine levels after HS in rats...
  67. ncbi The role of the lung in postinjury multiple organ failure
    David J Ciesla
    Department of Surgery, Denver Health Medical Center, Denver, Colorado 80204, USA
    Surgery 138:749-57; discussion 757-8. 2005
    Postinjury multiple organ failure (MOF) is a result of a dysfunctional inflammatory response to severe injury and shock...
  68. ncbi Mortality in severely injured elderly trauma patients--when does age become a risk factor?
    Christian A Kuhne
    Department of Trauma Surgery, University Hospital Essen, Essen, Germany
    World J Surg 29:1476-82. 2005
    ..Outcome measures were mortality, shock, multiple organ failure, and severe head injury...
  69. pmc Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure
    Joseph Cuschieri
    Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Shock 34:346-51. 2010
    ..This measurement may be useful as a biomarker for prognosis and serve to identify patients at higher risk of adverse outcome that would benefit from novel therapeutic interventions...
  70. pmc 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study
    Krisztina Madách
    Department of Anesthesiology and Intensive Therapy, Semmelweis University, Kutvolgyi ut 4, Budapest, Hungary
    Crit Care 14:R79. 2010
    ..Elevated levels of PAI-1 have been related to worse outcome in pneumonia. We aimed to evaluate the effect of functionally relevant 4G/5G polymorphism of PAI-1 gene in pneumonia induced sepsis...
  71. ncbi Early expression of pro- and anti-inflammatory cytokines in left ventricular assist device recipients with multiple organ failure syndrome
    Raffaele Caruso
    CNR Clinical Physiology Institute Milan, Milan, Italy
    ASAIO J 56:313-8. 2010
    ..profiles early after left ventricular assist device (LVAD) implant discriminates patients at high risk for multiple organ failure syndrome (MOFS) in the first month post-LVAD, we analyzed plasma interleukin (IL)-6, IL-8, IL-10, IL-1ra, ..
  72. ncbi Polymyxin-direct hemoperfusion for sepsis-induced multiple organ failure
    Koichi Hirabayashi
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Pediatr Blood Cancer 55:202-5. 2010
    We report a case of multiple organ failure caused by the Bacillus cereus infection during acute lymphoblastic leukemia therapy, who was treated successfully. A 15-year-old male developed (B...
  73. ncbi Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock
    Matthias W A Angstwurm
    Medizinische Klinik Innenstadt, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Crit Care Med 35:118-26. 2007
    ..We postulated that high-dose supplementation of sodium-selenite would improve the outcome of patients with severe sepsis and septic shock...
  74. ncbi Anti-inflammatory cytokine response and the development of multiple organ failure in severe sepsis
    P Loisa
    Departments of Anaesthesia and Intensive Care, Tampere University Hospital, Tampere, Finland
    Acta Anaesthesiol Scand 47:319-25. 2003
    ..In this prospective study, we investigated the relationship between the pro- and anti-inflammatory cytokine profiles in severe sepsis and their role in the development of multiple organ failure (MOF).
  75. ncbi Intravenous paraquat poisoning-induced multiple organ failure and fatality--a report of two cases
    Hsiang Hao Hsu
    Poison Center and Department of Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC
    J Toxicol Clin Toxicol 41:87-90. 2003
    ..and cyclophosphamide was attempted in both cases; however, both cases died within five days owing to multiple organ failure. In cases of intravenous paraquat intoxication, toxic signs develop more quicker than with oral ingestion...
  76. ncbi Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis
    A Olah
    Department of Surgery, Petz Aladar Teaching Hospital, Gyor, Hungary
    Br J Surg 89:1103-7. 2002
    ..The aim of this study was to determine whether lactic acid bacteria such as Lactobacillus plantarum 299 could prevent colonization of the gut by potential pathogens and thus reduce the endotoxaemia associated with acute pancreatitis...
  77. ncbi Morbid obesity in the medical ICU
    A El-Solh
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, James P Nolan Clinical Research Center, University at Buffalo School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
    Chest 120:1989-97. 2001
    ..To describe the clinical course, complications, and prognostic factors of morbidly obese patients admitted to the ICU compared to a control group of nonobese patients...
  78. ncbi Polymorphisms in the toll-like receptor 9 gene associated with sepsis and multiple organ dysfunction after major blunt trauma
    K H Chen
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Chongqing, China
    Br J Surg 98:1252-9. 2011
    ..However, little is known about the clinical relevance of TLR9 gene polymorphisms in critical illness...
  79. ncbi Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure
    Evangelos Cholongitas
    Fourth Department of Internal Medicine, Medical School of Aristotle University, Hippokration General Hospital of Thessaloniki, Thessaloniki, Greece
    Liver Transpl 18:405-12. 2012
    ..A further evaluation of SOFA with the KCH criteria is warranted...
  80. pmc Altered gut flora are associated with septic complications and death in critically ill patients with systemic inflammatory response syndrome
    Kentaro Shimizu
    Department of Clinical Quality Management, Osaka University Hospital, and Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Dig Dis Sci 56:1171-7. 2011
    ..There are few reports, however, about the relationship between gut flora and septic complications...
  81. ncbi Clinical characteristics and outcomes of patients with 2009 influenza A(H1N1) virus infection with respiratory failure requiring mechanical ventilation
    Nicolas Nin
    Hospital Universitario de Getafe and CIBER de Enfermedades Respiratorias, Madrid, Spain
    J Crit Care 26:186-92. 2011
    ..The purpose of the study was to describe the clinical characteristics and outcomes of critically ill patients with 2009 influenza A(H1N1)...
  82. ncbi A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the ra
    G M Wray
    The William Harvey Research Institute and the Department of Intensive Care, St. Bartholomew's and the Royal London School of Medicine and Dentistry, United Kingdom
    Shock 15:135-42. 2001
    ....
  83. ncbi 15d-prostaglandin J2 reduces multiple organ failure caused by wall-fragment of Gram-positive and Gram-negative bacteria
    Laura Dugo
    Department of Experimental Medicine, Nephrology and Critical Care Medicine, The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    Eur J Pharmacol 498:295-301. 2004
    ..We propose that 15d-prostaglandin J2 or other ligands for PPAR-gamma may be useful in the therapy of the organ injury associated with septic shock...
  84. ncbi Identification of haplotype tag SNPs within the entire TLR2 gene and their clinical relevance in patients with major trauma
    Ke Hong Chen
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Chongqing, China
    Shock 35:35-41. 2011
    ..The rs3804099 and the haplotype ATT might be used as relevant risk estimates for the development of sepsis and MOD in patients with major trauma...
  85. ncbi Factors associated with maternal death in women admitted to an intensive care unit with severe maternal morbidity
    Antonio F Oliveira Neto
    Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Int J Gynaecol Obstet 105:252-6. 2009
    ..To identify factors associated with maternal death among women with severe maternal morbidity...
  86. ncbi Early lactate clearance is associated with improved outcome in severe sepsis and septic shock
    H Bryant Nguyen
    Department of Emergency Medicine HBN, Loma Linda University and Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USA
    Crit Care Med 32:1637-42. 2004
    ..We hypothesize that a high lactate clearance in 6 hrs is associated with decreased mortality rate...
  87. pmc Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis
    Robert Silasi-Mansat
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Blood 116:1002-10. 2010
    Severe sepsis leads to massive activation of coagulation and complement cascades that could contribute to multiple organ failure and death...
  88. ncbi Impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome: systematic review of randomized controlled trials
    Luciano Silvestri
    Department of Emergency, Unit of Anesthesia and Intensive Care, Presidio Ospedaliero, Gorizia, Italy
    Crit Care Med 38:1370-6. 2010
    ..We examined the impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome...
  89. ncbi Endovascular treatment of an iliocaval arteriovenous fistula presenting with multiple organ failure
    Stijn Schepers
    Department of Vascular Surgery, University Hospital Leuven, Leuven, Belgium
    Surg Laparosc Endosc Percutan Tech 19:e244-6. 2009
    ..We report a case of iliocaval fistula after previous aortic surgery presenting as acute liver failure as most prominent part of multiple organ failure and successful endovascular repair.
  90. ncbi Multiple organ failure associated with extensive metastatic calcification in a patient with an intermediate state of human T lymphotropic virus type I (HTLV-I) infection: report of an autopsy case
    H Kumamoto
    Department of Oral Pathology, Tohoku University School of Dentistry, Sendai, Japan
    Pathol Int 48:313-8. 1998
    ..an intermediate state of human T lymphotropic virus type I (HTLV-I) infection and in whom autopsy showed multiple organ failure (MOF) associated with extensive metastatic calcification in systemic organs is described...
  91. ncbi NISS predicts postinjury multiple organ failure better than the ISS
    Z Balogh
    Department of Surgery, Denver Health Medical Center, University of Colorado Health Sciences Center, 80204, USA
    J Trauma 48:624-7; discussion 627-8. 2000
    The Injury Severity Score (ISS) has been observed consistently to be a robust predictor of postinjury multiple organ failure (MOF). However, the ISS fails to account for multiple injuries to the same body region...
  92. ncbi Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure
    Lars E Schmidt
    Department of Hepatology, Rigshospitalet, Copenhagen, Denmark
    Crit Care Med 34:337-43. 2006
    ..study were to further evaluate arterial lactate as a prognostic marker in acetaminophen-induced fulminant hepatic failure and to analyze its relationship to known causes of hyperlactatemia such as multiple organ failure and inflammation.
  93. pmc PPARα mediates the anti-inflammatory effect of simvastatin in an experimental model of zymosan-induced multiple organ failure
    Barbara Rinaldi
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Excellence Centre for Cardiovascular Diseases, Second University of Naples, Italy
    Br J Pharmacol 163:609-23. 2011
    ..We used a zymosan-induced non-septic shock experimental model to investigate the role of PPARα in the anti-inflammatory effects of simvastatin...
  94. ncbi Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation
    M Levi
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 29:S90-4. 2001
    ....
  95. ncbi Lipid composition and lipopolysaccharide binding capacity of lipoproteins in plasma and lymph of patients with systemic inflammatory response syndrome and multiple organ failure
    Johannes H M Levels
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Crit Care Med 31:1647-53. 2003
    ..Lipoproteins (in particular, high-density lipoproteins) sequester LPS, thereby acting as a humoral detoxification mechanism...
  96. ncbi Acute respiratory distress syndrome and multiple organ failure
    Lorenzo Del Sorbo
    Dipartimento di Anestesia e Terapia Intensiva, Azienda Ospedaliera San Giovanni Battista, Universita di Torino, Italy
    Curr Opin Crit Care 17:1-6. 2011
    ..The predominant cause of death in ARDS is not severe hypoxemia, which is one of the defining criteria of ARDS, but multiple organ failure (MOF).
  97. ncbi Postinjury immune monitoring: can multiple organ failure be predicted?
    Tjaakje Visser
    Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Opin Crit Care 14:666-72. 2008
    b>Multiple organ failure is the main cause of late morbidity and mortality after severe injury. This disease state is driven by a dysfunctional immune system...
  98. pmc Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure
    Katarina Fredriksson
    Department of Anesthesiology and Intensive Care, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
    PLoS ONE 3:e3686. 2008
    Septic patients treated in the intensive care unit (ICU) often develop multiple organ failure including persistent skeletal muscle dysfunction which results in the patient's protracted recovery process...
  99. ncbi Scandinavian glutamine trial: a pragmatic multi-centre randomised clinical trial of intensive care unit patients
    Jan Wernerman
    Department of Anesthesia and Intensive Care Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Acta Anaesthesiol Scand 55:812-8. 2011
    ..The hypothesis was that the change in the SOFA score would be improved by glutamine supplementation...
  100. ncbi Is there a role for plasmapheresis/plasma exchange therapy in septic shock, MODS, and thrombocytopenia-associated multiple organ failure? We still do not know--but perhaps we are closer
    Joseph A Carcillo
    Intensive Care Med 28:1373-5. 2002
  101. ncbi Organ crosstalk: the role of the kidney
    Xiang Li
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Curr Opin Crit Care 15:481-7. 2009
    ..This review will examine our current understanding of the deleterious organ crosstalk in the critically ill, which can provide a framework for developing novel therapeutics...

Research Grants63

  1. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..In those that survive the initial injury and hypovolemic circulatory collapse, multiple organ failure (MOF) is the most important contributor to mortality...
  2. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..inhibitor in vitro, and remarkably protective in vivo, as shown in murine LD100 models of zymosan-induced multiple organ failure and chlorine inhalational lung injury...
  3. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..In murine LD100 models of zymosan-induced multiple organ failure (MOF) and Cl2 inhalational lung injury, resuscitation with R-503 begun after the onset of zymosan ..
  4. MOLECULAR BIOLOGY OF HEMORRHAGIC SHOCK
    Timothy R Billiar; Fiscal Year: 2013
    ..approaches to limit not only the early organ damage but also the susceptibility to late sepsis and multiple organ failure (MOF)...
  5. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer L Coburn; Fiscal Year: 2010
    ..of the genus Leptospira, and varies in severity from mild illness to fatal hemorrhagic disease with multiple organ failure. Disease severity varies with the host species, host age and health status, and the infecting strain...
  6. Lactoferrin for Immunomodulation of Systemic Inflammatory Response Syndrome
    Marian L Kruzel; Fiscal Year: 2011
    ..of complex acute-phase intrinsic mediators that precedes sepsis and subsequent tissue damage leading to Multiple Organ Failure. The systemic inflammatory response syndrome (SIRS) is a precursor to sepsis, and has been implicated as ..
  7. L-carnitine Treatment for Vasopressor Dependent Septic Shock
    Alan E Jones; Fiscal Year: 2013
    ..Death from sepsis is the culmination of widespread hypoperfusion, cellular hypoxia, and multiple organ failure. A growing body of evidence shows that early therapeutic intervention improves outcomes for patients with ..
  8. Triplex-mediated DNA repair as a novel therapy for Hurler Syndrome patients
    Elizabeth Peterson-Roth; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Hurler Syndrome (HS), a devastating genetic disease that results in multiple organ failure with progressive deterioration in the central nervous system, is caused by mutations in a single gene that ..
  9. PPARgamma and PPARgamma agonists in septic shock
    Basilia Zingarelli; Fiscal Year: 2013
    ..will also establish whether AMPK activators mitigate sepsis-induced systemic inflammatory response, multiple organ failure and death...
  10. Molecular Control of Gut Permeability in Trauma
    Mack H Wu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Trauma-induced inflammation and multiple organ failure are a major cause of mortality and morbidity in American soldiers and veterans...
  11. The Role of MKP-1 in innate immune responses to LPS
    Yusen Liu; Fiscal Year: 2010
    ..Severe sepsis is often associated with profound hypotension, massive vasodilation, shock, and multiple organ failure. The mechanisms leading to the cardiovascular collapse are not fully understood...
  12. A Novel Therapeutic Approach for Liver Injury
    Xiaoling Qiang; Fiscal Year: 2010
    ..Hepatic I/R contributes significantly to multiple organ failure and mortality...
  13. Collaborative Pediatric Critical Care Research Network At Children's Hospital of
    Joseph A Carcillo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sepsis-induced multiple organ failure (MOF) remains an important cause of child morbidity and death...
  14. In Silico Model for Acute Lung Injury Prediction and Clinical Trial Design
    Ognjen Gajic; Fiscal Year: 2010
    ..Subsequent progression to multiple organ failure carries a grave prognosis with high mortality, and long term morbidity affecting both patients and ..
  15. Caspase-1 and Inflammasome Activation in Traumahemorrhagic Shock
    Melanie J Scott; Fiscal Year: 2013
    ..by applicant): Controlling inflammation and cellular damage is the key to preventing and treating multiple organ failure (MOF) following trauma...
  16. Preservation of mucosal barrier in surgical diseases
    Xiao Di Tan; Fiscal Year: 2013
    ..mucosal injury, which can lead to the development of systemic infection, septic shock, and multiple organ failure. Restitution is an important process for repair of disrupted intestinal lining...
  17. Cell-Binding Adhesins of Leptospira interrogans
    Jenifer L Coburn; Fiscal Year: 2013
    ..of the genus Leptospira, and varies in severity from mild illness to fatal hemorrhagic disease with multiple organ failure. Disease severity varies with the host species, host age and health status, and the infecting strain...
  18. Cholinergic regulation of NF-kB in sepsis
    Luis Ulloa; Fiscal Year: 2012
    ..severe sepsis, which is characterized by an overwhelming systemic inflammatory response that causes lethal multiple organ failure. Our goal is to develop novel therapeutic strategies to restrain systemic inflammation and improve ..
  19. Programmed Cell Death: Role in Septic Immune Dysfunction
    Alfred Ayala; Fiscal Year: 2013
    ..by applicant): The inability of the present therapies to mitigate the devastating effects of sepsis and multiple organ failure in the critically ill patient indicates that more knowledge of the pathophysiology of sepsis is needed if ..
  20. Gut Circadian Clock and Melatonin Dynamics Following Major Thermal Injury
    Walid M Al Ghoul; Fiscal Year: 2013
    ..uncontrolled systemic inflammatory response associated with or triggered by infection and often leading to multiple organ failure and death...
  21. Development of lisinopril for post-exposure mitigation of late effects from a rad
    MEETHA M MEDHORA; Fiscal Year: 2013
    ..We are now aiming to repurpose these drugs as mitigators for radiation-induced multiple organ failure, in survivors of acute hematological syndromes...
  22. PREVENTION OF APOPTOTIC CELL DEATH IN SEPSIS BY BCL-2
    RICHARD SAMUEL HOTCHKISS; Fiscal Year: 2012
    ..most intensive care units with over 210,000 people succumbing to overwhelming infection (or the resultant multiple organ failure) in the United States annually...
  23. CD14: Biosynthesis, Trafficking and Secretion
    DIEGO FERNANDO NINO; Fiscal Year: 2013
    ..inflammatory response is responsible for the transition between sepsis and septic shock and subsequently multiple organ failure, which are responsible for the majority casualties from sepsis...
  24. Regulation of Age-Related Inflammation in Septic Shock
    Ping Wang; Fiscal Year: 2010
    ..Despite advances in the management of sepsis, a large number of such patients die of septic shock and multiple organ failure. Sepsis is particularly a serious problem in the geriatric population since elderly patients with sepsis ..
  25. Fatal Attration: T lymphocytes and liver endothelial cell during sepsis.
    NOELLE A HUTCHINS; Fiscal Year: 2012
    ..Sepsis is often defined as a whole-body inflammatory state, leading to multiple organ failure. Our laboratory studies murine models of polymicrobial sepsis, and how immune dysfunction contributes to ..
  26. Neutrophil Collagenase in Sepsis and Ventilator Induced Lung Injury
    A Murat Kaynar; Fiscal Year: 2013
    ..uncontrolled accumulation of these cells could also lead to end-organ damage, one of the major reasons for multiple organ failure, including ALL Chemotaxis of neutrophils to the site of infection or inflammation are essential to this ..
  27. Ethanol, Lung Mesenchymal Stem Cells and Pulmonary Inflammation After Burn Injury
    JILL ANN IPPOLITO; Fiscal Year: 2013
    ..the combined insult of alcohol and burn injury causes increased risk of pulmonary complications leading to multiple organ failure and death...
  28. Is Aberrant MO Stimulation Pivotal in Post-Trauma MODS?
    Carol L Miller-Graziano; Fiscal Year: 2012
    ..of both the innate and adaptive immune responses resulting in opportunistic infections &multiple organ failure (MOF)...
  29. Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury (CITRIS-ALI)
    Jonathon D Truwit; Fiscal Year: 2013
    ..vitamin C levels are a consistent feature in septic patients, varying inversely with the incidence of multiple organ failure and directly with survival No multicenter trials have examined parenteral vitamin C infusion as an ..
  30. Mesenchymal Stem Cell Therapy for Corneal Cystinosis
    JENNIFER LYNNE SIMPSON; Fiscal Year: 2013
    ..cystinosin (CTNS) that leads to cystine crystal formation in various tissues and organs resulting in multiple organ failure at an early age...
  31. Enhanced Propagation of Adult Human Renal Epithelial Cells
    Angela Westover; Fiscal Year: 2009
    ..renal devices are in development to ameliorate the effects of ARF, acute tubular necrosis (ATN), multiple organ failure (MOF), sepsis and cardiorenal syndrome (CRS)...
  32. ASDAMTS-13 and Inflammation
    TRUNG CHANH NGUYEN; Fiscal Year: 2012
    ..one with severe sepsis, a form of systemic inflammation, and the other with thrombocytopenia-associated multiple organ failure. More than 50% of these children have a deficiency in von Willebrand factor (VWF)-cleaving protease (a.k.a...
  33. Age of Blood in Children in Pediatric Intensive Care Units
    Philip C Spinella; Fiscal Year: 2013
    ..Inadequate treatment of shock will increase the risk of multiple organ failure and mortality through multiple cell death pathways...
  34. Complement inhibition as sepsis therapy
    Florea Lupu; Fiscal Year: 2013
    ..to the invading bacteria leads to hypo-perfusion and ischemia-reperfusion (IR) injury that evolves to multiple organ failure (MOF) and ultimately to death...
  35. Enhanced Propagation of Adult Human Renal Epithelial Cells Allowing for Commercia
    Angela J Westover; Fiscal Year: 2011
    ..and overall health of patients suffering from acute renal failure (ARF), acute tubular necrosis (ATN), multiple organ failure (MOF), sepsis, cardiorenal syndrome (CRS) and end stage renal disease (ESRD)...
  36. Shock, trauma and gut origin of sepsis
    Edwin A Deitch; Fiscal Year: 2012
    ..25 years that the development of a dysregulated inflammatory response as well as lung injury (ARDS) and multiple organ failure complicates the recovery of patients with severe trauma...
  37. Regulatory Mechanisms for Resolution of Inflammatory Microvascular Leakage
    Jerome W Breslin; Fiscal Year: 2013
    ..complicates resuscitation of trauma victims and worsens clinical outcomes, frequently progressing to multiple organ failure. The estimated annual US health care cost burden associated with SIRS is $16.7 billion...
  38. Role of CD14 and other innate immune receptors in severe sepsis
    Sanna M Goyert; Fiscal Year: 2012
    ..severe tissue damage and lead to complications such as acute respiratory distress syndrome (ARDS) and multiple organ failure. Despite its clinical importance, the regulation of neutrophil migration remains poorly understood...
  39. Validation of extracellular histones as biomarker and therapeutic target in sepsi
    FLOREA contact LUPU; Fiscal Year: 2010
    ..is a multi-factorial disorder that triggers an uncontrolled inflammatory response, ultimately leading to multiple organ failure and death...
  40. Biomarker for liver ischemia/reperfusion-induced injury
    MONIKA OLI; Fiscal Year: 2006
    ..injury, hemorrhagic and septic shock, and liver transplantation, which contributes significantly to multiple organ failure and mortality...
  41. Novel Modular Vascular Patterning Assay for HTS
    Royce Mohan; Fiscal Year: 2010
    ..and spread of cancers, and contributing to debilitating arthritis, age-related macular degeneration and multiple organ failure associated with underlying diseases such as diabetes...
  42. Inhibition of Cardiac Device Induced Cellular Dysfunction in Pigs
    REKHA BANSAL; Fiscal Year: 2012
    ..Collective effects of these inflammatory events on multiple organ failure will be evaluated in this proposal using the proposed pig cardiopulmonary bypass model...
  43. Regulation of endothelial permeability in sepsis
    Michelle L Matter; Fiscal Year: 2013
    ..Over time this can lead multiple organ failure and death. Currently there are no therapies for blocking vascular leakage in sepsis...
  44. Microvascular Permeability and Matrix Fibrinogen Degradation in Trauma
    Mack H Wu; Fiscal Year: 2013
    ..degradation products (FDPs), have been associated with the development of systemic inflammation and multiple organ failure in trauma patients...
  45. Microvascular Barrier Dysfunction in Thermal Injury
    Sarah Y Yuan; Fiscal Year: 2013
    ..One of the mechanisms underlying multiple organ failure is microvascular barrier dysfunction, a cellular process that has yet to be understood at the molecular ..
  46. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2006
    ..expression), or its progression to septic shock with disseminated intravascular coagulation (DIG) and multiple organ failure (MOF)...
  47. Effects of Damage Control Resuscitation on the Inflammatory Response to Hemorrhag
    Timothy A Pritts; Fiscal Year: 2012
    ..blood cells leads to decreased immediate mortality in trauma patients but may allow subsequent death from multiple organ failure. To date, there are no studies examining the impact of damage control resuscitation strategies, as ..
  48. Validation of the Denver Trauma Organ Failure Score
    JODY ANN VOGEL; Fiscal Year: 2013
    ..1-4 Multiple organ failure (MOF) is common among the most seriously-injured and is the leading cause of morbidity and mortality among ..
  49. MOLECULAR MECHANISMS OF SEPTIC SHOCK
    JACK HAWIGER; Fiscal Year: 2003
    ..Septic shock along with acute respiratory distress syndrome and multiple organ failure constitutes the extreme form of systemic inflammatory response syndrome...
  50. PARP inhibitor therapy for septic shock
    Andrew Salzman; Fiscal Year: 2004
    Progression of septic shock to multiple organ failure (MOF) is mediated by the activation of poly(ADP-ribose) polymerase ("PARP"), a nuclear cell death enzyme that catalyzes intracellular energetic failure and necrosis...
  51. IMMUNOPATHOLOGICAL ASPECTS OF THREMAL INJURY
    Martin G Schwacha; Fiscal Year: 2011
    ..to numerous complications that include delayed wound healing, increased susceptibility to sepsis and multiple organ failure. A wide range of mediators and cell types closely regulate the post-burn inflammatory process...
  52. Pheresis Treatment of Bioterrorism-Induced Sepsis
    Stephen Ash; Fiscal Year: 2005
    ..novel treatment for sepsis has already been tested in Phase I clinical trials in patients with sepsis and multiple organ failure. This system, the Biologic-DTPF, consisted of a dialysis system (DT) and a pheresis system (PF) in series...
  53. Adhesion of Leptospira interrogans to Human Cell Surface Receptors
    Jenifer Coburn; Fiscal Year: 2009
    ..of the genus Leptospira, and can vary in severity from mild illness to fatal hemorrhagic disease with multiple organ failure. Pathogenicity can vary depending on the host species, host age and health status, and on the infecting ..
  54. MYELOPOIETIC STIMULATION FOLLOWING BURN INJURY
    Richard Gamelli; Fiscal Year: 2007
    ..Many of these patients succumb to infections that lead to unabated systemic inflammatory response and multiple organ failure. Burn trauma is associated with loss of the barrier and immune protection afforded by the skin...
  55. Direct Peritoneal Resuscitation from Hypovolemic Shock
    Richard Garrison; Fiscal Year: 2007
    ..These pathophysiologic events cause local and remote tissue injury that culminates in multiple organ failure (MOF) by mechanisms, which are poorly understood...
  56. SURGERY AND IV NUTRITION MODULATE MACROPHAGE FUNCTION
    W Helton; Fiscal Year: 1999
    ..in TPN-fed patients results in an altered neuroendocrine and catabolic response which may contribute to multiple organ failure and increased mortality during surgical critical illness...
  57. The Lung as a Source of Inflammation in Sepsis
    Edmund Miller; Fiscal Year: 2009
    ..patients can often be adequately supported, and mortality most often results from unresolved sepsis or multiple organ failure. Previous studies have focused on how systemic manifestations of sepsis affect the lung...
  58. Regulation of Arginase Genes in Sepsis and Trauma
    Sidney Morris; Fiscal Year: 2005
    ..In extreme conditions, these responses can result in death due to organ dysfunction and multiple organ failure. Major changes in arginine metabolism are major hallmarks of these pathophysiologic states...
  59. MODULATION OF HEPATOCELLULAR FUNCTION IN EARLY SEPSIS
    Ping Wang; Fiscal Year: 2000
    ..in the management of septic patients, large number of such patients subsequently die from the ensuing multiple organ failure. This could be due to the fact that some of the subtle changes in cellular functions during early sepsis ..
  60. MODULATION OF HEPATOCELLULAR FUNCTION IN EARLY SEPSIS
    Ping Wang; Fiscal Year: 2000
    ..Despite advances in the management of septic patients, a large number of such patients subsequently die from multiple organ failure. This could be due to the fact that some of the subtle changes in cellular function during early sepsis ..
  61. Lyso-PCs activate PMNs and endothelium via PKC
    CHRISTOPHER SILLIMAN; Fiscal Year: 2006
    ..older packed red blood cells are independently associated with the development of acute lung iinjury and multiple organ failure in injured aptients...
  62. Gut Ischemia/Reperfusion Injury: Modulation by Nutrients
    Rosemary Kozar; Fiscal Year: 2006
    ..has become very active in the NIGMS-sponsored Trauma Research Center, focusing on the role of the gut in multiple organ failure. A Career Development Award, in conjunction with the support of two highly respected mentors, would ..
  63. THERMAL INJURY INDUCED ALTERATIONS IN IMMUNE FUNCTION
    Martin Schwacha; Fiscal Year: 2003
    Immune dysfunction, susceptibility to sepsis and multiple organ failure are complications associated with thermal injury...