metaplasia

Summary

Summary: A condition in which there is a change of one adult cell type to another similar adult cell type.

Top Publications

  1. pmc Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs
    Geou Yarh Liou
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA
    J Cell Biol 202:563-77. 2013
  2. pmc Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
    Janel L Kopp
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Cancer Cell 22:737-50. 2012
  3. ncbi Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
    Joseph Milano
    Safety Assessment US, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850, USA
    Toxicol Sci 82:341-58. 2004
  4. pmc Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
    Pierre Paul Prevot
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, B 1200 Brussels, Belgium
    Gut 61:1723-32. 2012
  5. pmc Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia
    Michael Quante
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Cell 21:36-51. 2012
  6. ncbi Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
    Anna L Means
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 132:3767-76. 2005
  7. pmc FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation
    Xiaomeng Ren
    Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    Mol Cell Biol 33:371-86. 2013
  8. ncbi Helicobacter pylori virulence genes and host IL-1RN and IL-1beta genes interplay in favouring the development of peptic ulcer and intestinal metaplasia
    C F Zambon
    Department of Laboratory Medicine, University of Padova, Italy
    Cytokine 18:242-51. 2002
  9. pmc Proteomic profiling of paraffin-embedded samples identifies metaplasia-specific and early-stage gastric cancer biomarkers
    Josane F Sousa
    Nashville Veterans Affairs Medical Center, Vanderbilt University School of Medicine, Tennessee, USA
    Am J Pathol 181:1560-72. 2012
  10. pmc The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist
    James R Goldenring
    Nashville Department of Veterans Affairs Medical Center, Nashville, TN, USA
    Exp Cell Res 317:2759-64. 2011

Detail Information

Publications345 found, 100 shown here

  1. pmc Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs
    Geou Yarh Liou
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, FL 32224, USA
    J Cell Biol 202:563-77. 2013
    In response to inflammation, pancreatic acinar cells can undergo acinar-to-ductal metaplasia (ADM), a reprogramming event that induces transdifferentiation to a ductlike phenotype and, in the context of additional oncogenic stimulation, ..
  2. pmc Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
    Janel L Kopp
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Cancer Cell 22:737-50. 2012
    ..These results provide insight into the cellular origin of PDA and suggest that its precursors arise via induction of a duct-like state in acinar cells...
  3. ncbi Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation
    Joseph Milano
    Safety Assessment US, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850, USA
    Toxicol Sci 82:341-58. 2004
    ..7 nM), and a benzodiazepine (BZ) (2.2 nM). The DBZ and BZ caused dose-dependent intestinal goblet cell metaplasia. In contrast, the AS produced no detectable in vivo toxicity, despite higher exposure to free drug...
  4. pmc Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
    Pierre Paul Prevot
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, B 1200 Brussels, Belgium
    Gut 61:1723-32. 2012
    ..is characterised by the co-expression of acinar and ductal markers in acini, a lesion called acinar-to-ductal metaplasia (ADM)...
  5. pmc Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia
    Michael Quante
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Cell 21:36-51. 2012
    Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis...
  6. ncbi Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
    Anna L Means
    Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Development 132:3767-76. 2005
    Epithelial metaplasia occurs when one predominant cell type in a tissue is replaced by another, and is frequently associated with an increased risk of subsequent neoplasia...
  7. pmc FOXM1 promotes allergen-induced goblet cell metaplasia and pulmonary inflammation
    Xiaomeng Ren
    Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    Mol Cell Biol 33:371-86. 2013
    ..COPD), cystic fibrosis, and asthma, are associated with persistent pulmonary inflammation and goblet cell metaplasia and contribute to significant morbidity and mortality worldwide...
  8. ncbi Helicobacter pylori virulence genes and host IL-1RN and IL-1beta genes interplay in favouring the development of peptic ulcer and intestinal metaplasia
    C F Zambon
    Department of Laboratory Medicine, University of Padova, Italy
    Cytokine 18:242-51. 2002
    ..Intestinal metaplasia was associated with cagA, functional oipA and IL-1RN 2 allele...
  9. pmc Proteomic profiling of paraffin-embedded samples identifies metaplasia-specific and early-stage gastric cancer biomarkers
    Josane F Sousa
    Nashville Veterans Affairs Medical Center, Vanderbilt University School of Medicine, Tennessee, USA
    Am J Pathol 181:1560-72. 2012
    ..mass spectrometry analysis to generate proteomic profiles from FFPE samples of intestinal-type gastric cancer, metaplasia, and normal mucosa...
  10. pmc The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist
    James R Goldenring
    Nashville Department of Veterans Affairs Medical Center, Nashville, TN, USA
    Exp Cell Res 317:2759-64. 2011
    ..loss of acid-secreting parietal cell, the chief cell lineage can itself trasndifferentiate into a mucous cell metaplasia designated Spasmolytic Polypeptide Expressing Metaplasia (SPEM)...
  11. ncbi Magnification chromoendoscopy for the diagnosis of gastric intestinal metaplasia and dysplasia
    Mario Dinis-Ribeiro
    Instituto Portugues de Oncologia Francisco Gentil, Centro do Porto, Faculdade de Medicina do Porto, Hospital de S Joao, Portugal
    Gastrointest Endosc 57:498-504. 2003
    The aim of this study was to define the reproducibility and accuracy of magnification chromoendoscopy for the diagnosis of lesions associated with gastric cancer (intestinal metaplasia and dysplasia).
  12. pmc CDX1 and CDX2 expression in intestinal metaplasia, dysplasia and gastric cancer
    Jung Mook Kang
    Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea
    J Korean Med Sci 26:647-53. 2011
    Intestinal metaplasia (IM) has been regarded as a premalignant condition. However, the pathogenesis of IM is not fully understood...
  13. pmc Notch signaling promotes airway mucous metaplasia and inhibits alveolar development
    J Sawalla Guseh
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 136:1751-9. 2009
    ..Normally, airway mucous cells are rare. However, diseases of the airway are often characterized by mucous metaplasia, in which there are dramatic increases in mucous cell numbers...
  14. pmc LI-cadherin: a marker of gastric metaplasia and neoplasia
    C Grotzinger
    Department of Internal Medicine, Division of Hepatology and Gastroenterology, Charité Medical School of the Humboldt University of Berlin, Berlin, Germany
    Gut 49:73-81. 2001
    Intestinal metaplasia is considered a risk factor for the development of gastric adenocarcinomas of the intestinal type and is found in approximately 20% of gastric biopsies...
  15. doi Inhibition of neutrophil elastase-induced goblet cell metaplasia by tiotropium in mice
    N Arai
    First Dept of Medicine, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Eur Respir J 35:1164-71. 2010
    ..We hypothesised that tiotropium has the ability to inhibit neutrophil elastase (NE)-induced goblet cell metaplasia in mice and mucin production in vitro...
  16. ncbi Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach
    Yun Qing Bai
    Department of Surgery, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Lett 176:47-55. 2002
    ..We have studied the expression of CDX2/1 in gastric cancers and intestinal metaplasia (IM) of 69 gastric carcinoma patients by immunohistochemistry...
  17. pmc In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia
    Oliver Strobel
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 133:1999-2009. 2007
    Chronic injury results in regeneration of normal pancreatic tissue and formation of a metaplasia of ductal phenotype...
  18. doi Acid, bile, and CDX: the ABCs of making Barrett's metaplasia
    Rhonda F Souza
    Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical School, USA
    Am J Physiol Gastrointest Liver Physiol 295:G211-8. 2008
    Barrett's esophagus, a squamous-to-columnar cell metaplasia that develops as a result of chronic gastroesophageal reflux disease (GERD), is a risk factor for esophageal adenocarcinoma...
  19. doi Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands
    Annemarie C de Vries
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gastroenterology 134:945-52. 2008
    A cascade of precursor lesions (eg, atrophic gastritis, intestinal metaplasia, and dysplasia) precedes most gastric adenocarcinomas. Quantification of gastric cancer risk in patients with premalignant gastric lesions is unclear, however...
  20. ncbi A new method of diagnosing gastric intestinal metaplasia: narrow-band imaging with magnifying endoscopy
    N Uedo
    Deparment of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Endoscopy 38:819-24. 2006
    With endoscopy, there is a high rate of interobserver variability in the identification of gastric intestinal metaplasia, and the endoscopic findings correlate poorly with the histological findings...
  21. ncbi Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members
    Anand C Patel
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Physiol Genomics 25:502-13. 2006
    ..obstructive pulmonary disease exhibit stereotyped traits (especially airway hyperreactivity and mucous cell metaplasia) that are variably expressed in each patient...
  22. doi Intestinal metaplasia: a premalignant lesion involved in gastric carcinogenesis
    Rita A Busuttil
    Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Gastroenterol Hepatol 24:193-201. 2009
    ..What is the evidence that intestinal metaplasia (IM) is a premalignant condition? What should the clinician know about IM and the relative risks of progression ..
  23. doi Proinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers: implications for chronic obstructive pulmonary disease therapy
    Michael Herfs
    Laboratory of Experimental Pathology, GIGA Cancer, University of Liege, Belgium
    Am J Respir Cell Mol Biol 47:67-79. 2012
    Tracheobronchial squamous metaplasia is common in smokers, and is associated with both airway obstruction in chronic obstructive pulmonary disease (COPD) and increased risk of lung cancer...
  24. doi Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells
    Stuart A C McDonald
    Histopathology Unit, London Research Institute, Cancer Research UK, London, United Kingdom
    Gastroenterology 134:500-10. 2008
    ..mutations as a marker of clonal expansion, the clonality of the gastric unit and show how mutations expand in normal mucosa and gastric mucosa showing intestinal metaplasia. This has important implications in gastric carcinogenesis.
  25. doi Pseudomonas aeruginosa pyocyanin causes airway goblet cell hyperplasia and metaplasia and mucus hypersecretion by inactivating the transcriptional factor FoxA2
    Yonghua Hao
    Department of Pathobiology, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Cell Microbiol 14:401-15. 2012
    ..These studies demonstrate that PCN induces GCH and mucus hypersecretion by inactivating FoxA2...
  26. doi Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulation
    Rita Barros
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal
    Biochem Soc Trans 38:358-63. 2010
    IM (intestinal metaplasia) of the stomach is a pre-neoplastic lesion that usually follows Helicobacter pylori infection and that confers increased risk for gastric cancer development...
  27. pmc Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndrome
    Ying Ting Chen
    University of California, San Francisco, Francis I Proctor Foundation, San Francisco, CA 94143, USA
    Am J Pathol 177:1333-43. 2010
    ..This pathological process is known as squamous metaplasia. Based on a significant correlation between ocular surface interleukin (IL)-1beta expression and squamous ..
  28. ncbi IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo
    K Dabbagh
    Cardiovascular Research Institute and Departments of Medicine and Physiology, University of California, San Francisco, CA 94143, USA
    J Immunol 162:6233-7. 1999
    Goblet cell metaplasia and mucus hypersecretion are important features in the pathogenesis of asthma...
  29. pmc Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease
    Shimin Li
    Francis I Proctor Foundation, University of California San Francisco, 513 Parnassus, San Francisco, CA 94143, USA
    Invest Ophthalmol Vis Sci 49:34-41. 2008
    Squamous metaplasia occurs in ocular surface diseases like Sjögren's syndrome (SS)...
  30. pmc Cigarette smoke suppresses Bik to cause epithelial cell hyperplasia and mucous cell metaplasia
    Yohannes A Mebratu
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Am J Respir Crit Care Med 183:1531-8. 2011
    ..Because the Bcl-2 family of proteins is crucial for airway epithelial homeostasis, identifying the players that reduce cigarette smoke (CS)-induced mucous cell metaplasia can help to develop effective therapies.
  31. ncbi Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
    T C Wang
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 118:36-47. 2000
    ..Hypergastrinemia occurs frequently in association with acid suppression and Helicobacter infection, but its role in the progression to gastric atrophy and gastric cancer has not been well defined...
  32. pmc Non-sequential narrow band imaging for targeted biopsy and monitoring of gastric intestinal metaplasia
    Rungsun Rerknimitr
    Department of Medicine, Chulalongkorn University, Bangkok 10310, Thailand
    World J Gastroenterol 17:1336-42. 2011
    To evaluate the efficacy of non-sequential narrow band imaging (NBI) for a better recognition of gastric intestinal metaplasia (GIM).
  33. ncbi CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia
    Takao Hinoi
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Gastroenterology 123:1565-77. 2002
    ..Conversely, aberrant CDX2 expression is often seen in intestinal metaplasias in the stomach and esophagus and in some gastric carcinomas. To better understand CDX2 function, we sought to define CDX2-regulated genes...
  34. pmc Coupled nucleotide and mucin hypersecretion from goblet-cell metaplastic human airway epithelium
    Seiko F Okada
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    Am J Respir Cell Mol Biol 45:253-60. 2011
    ..bronchial epithelial (HBE) cultures, typically dominated by ciliated cells, were induced to develop goblet cell metaplasia by infection with respiratory syncytial virus (RSV) or treatment with IL-13...
  35. pmc Detection of p53 mutations in precancerous gastric tissue
    C Morgan
    Human Molecular Pathology Group, Swansea Clinical School, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    Br J Cancer 89:1314-9. 2003
    Intestinal-type gastric cancer is preceded by gastritis and intestinal metaplasia. There is uncertainty regarding the stage at which genetic alterations in the p53 gene occur...
  36. doi Paneth cell hyperplasia and metaplasia in necrotizing enterocolitis
    Patrycja J Puiman
    Department of Neonatology, Erasmus MC Sophia Children s Hospital, Rotterdam 3015 GJ, The Netherlands
    Pediatr Res 69:217-23. 2011
    ..Ileostomy fluid contained Paneth cell proteins and inhibited bacterial growth. In conjunction, these data suggest an important role of Paneth cells and their products in various phases of NEC...
  37. pmc Mature chief cells are cryptic progenitors for metaplasia in the stomach
    Ki Taek Nam
    Nashville VA Medical Center and the Department of Surgery, Epithelial Biology Center, Nashville, Tennessee, USA
    Gastroenterology 139:2028-2037.e9. 2010
    ..Indeed, mucous cell metaplasia is considered the critical preneoplastic lesion for gastric cancer...
  38. doi Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway
    Kyoung Seob Song
    The Airway Mucus Institute, Yonsei University College of Medicine, Seoul 120 752, Korea
    Am J Respir Cell Mol Biol 41:40-9. 2009
    ..These results give additional insights into the molecular mechanism of negative regulation of mucin overproduction and enhance our understanding of mucus hypersecretion during airway mucosal inflammation...
  39. pmc Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
    Liqin Zhu
    Department of Biological Sciences and the Purdue Cancer Center, Purdue University, Hansen Life Sciences Research Building, West Lafayette, IN 47907 2064, USA
    Am J Pathol 171:263-73. 2007
    ..In young animals (4 weeks), the predominant cellular alteration in the exocrine pancreas was acinar metaplasia in which individual acini consisted of acinar cells and duct-like cells...
  40. ncbi Detection rate of Helicobacter pylori against a background of atrophic gastritis and/or intestinal metaplasia
    Ji Youn Yoo
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi Do, South Korea
    J Clin Gastroenterol 41:751-5. 2007
    To evaluate the detection rate of the CLOtest, Giemsa stain, and culture for the diagnosis of Helicobacter pylori organisms in patients with or without atrophic gastritis (AG) and/or intestinal metaplasia (IM).
  41. doi Interobserver variability in the diagnosis of crypt dysplasia in Barrett esophagus
    Dominique P Coco
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 35:45-54. 2011
    ..Long-term and multi-institutional studies should be carried out to further determine the biological and clinical significance and natural history of CD in patients with BE...
  42. pmc Residual embryonic cells as precursors of a Barrett's-like metaplasia
    Xia Wang
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 145:1023-35. 2011
    Barrett's esophagus is an intestine-like metaplasia and precursor of esophageal adenocarcinoma. Triggered by gastroesophageal reflux disease, the origin of this metaplasia remains unknown...
  43. pmc Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication
    W K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong
    Gut 53:1244-9. 2004
    Gastric intestinal metaplasia (IM) is generally considered to be a precancerous lesion in the gastric carcinogenesis cascade. This study identified the risk factors associated with progression of IM in a randomised control study.
  44. pmc Risk of malignant progression in Barrett's esophagus patients: results from a large population-based study
    Shivaram Bhat
    Centre for Public Health, Queens University Belfast, Institute of Clinical Sciences Building, Belfast BT12 6BA, Northern Ireland, UK
    J Natl Cancer Inst 103:1049-57. 2011
    ....
  45. pmc IL-13 and epidermal growth factor receptor have critical but distinct roles in epithelial cell mucin production
    Guohua Zhen
    Department of Medicine, University of California, San Francisco, CA 94143 2922, USA
    Am J Respir Cell Mol Biol 36:244-53. 2007
    ....
  46. pmc Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation
    Gyeong Hoon Kang
    Department of Pathology and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Am J Pathol 163:1551-6. 2003
    ..pylori), acute and chronic inflammation, and intestinal metaplasia. Two hundred sixty-eight nonneoplastic gastric mucosa samples were studied for the methylation status of 11 ..
  47. pmc KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin
    Chanjuan Shi
    The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 212312, USA
    Mol Cancer Res 7:230-6. 2009
    ..To integrate findings in mice and men, we examined human acinar cells, acinar-ductal metaplasia (ADM) lesions, and PanINs for KRAS2 gene mutations...
  48. doi Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease
    Nayoung Kim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi Do, South Korea
    Helicobacter 13:245-55. 2008
    ..This study was performed to evaluate the prevalence of atrophic gastritis (AG) and intestinal metaplasia (IM) and to identify their risk factors with respect to H...
  49. ncbi Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas
    Raquel Almeida
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, 4200 Porto, Portugal
    J Pathol 199:36-40. 2003
    Intestinal metaplasia (IM) is part of a stepwise sequence of alterations of the gastric mucosa, leading ultimately to gastric cancer, and is strongly associated with chronic Helicobacter pylori infection...
  50. pmc Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients
    Jun Araya
    Department of Pathology, Lung Biology Center, UCSF, San Francisco, California 94110, USA
    J Clin Invest 117:3551-62. 2007
    Squamous metaplasia (SM) is common in smokers and is associated with airway obstruction in chronic obstructive pulmonary disease (COPD). A major mechanism of airway obstruction in COPD is thickening of the small airway walls...
  51. doi Metaplastic breast carcinomas are basal-like breast cancers: a genomic profiling analysis
    Britta Weigelt
    Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977 225A, Berkeley, CA 94720, USA
    Breast Cancer Res Treat 117:273-80. 2009
    ..Previous histopathological and immunohistochemical analysis of MBCs suggested that these cancers would have a basal-like profile...
  52. pmc Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements
    Hays W J Young
    Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Respir Cell Mol Biol 37:273-90. 2007
    ..mucins are the chief glycoprotein components of airway mucus, and elevated expression of these during mucous metaplasia precedes the hypersecretory phenotype...
  53. pmc Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas
    Howard C Crawford
    Department of Cancer Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 109:1437-44. 2002
    ..In a mouse model of pancreatic acinar-to-ductal metaplasia, MMP-7 progressively accumulates during the metaplastic transition, resulting in a concomitant increase in ..
  54. doi Narrow band imaging for characterization of high grade dysplasia and specialized intestinal metaplasia in Barrett's esophagus: a meta-analysis
    J Mannath
    Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Queens Medical Centre Campus, University of Nottingham, UK
    Endoscopy 42:351-9. 2010
    ..and microvasculature is increasingly advocated as a tool to detect and characterize neoplasia and intestinal metaplasia in patients with Barrett's esophagus...
  55. ncbi Diagnosis of specialized intestinal metaplasia by optical coherence tomography
    J M Poneros
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 120:7-12. 2001
    ..aim of this study was to establish the sensitivity and specificity of OCT for diagnosing specialized intestinal metaplasia (SIM). METHODS: OCT was used to image the stomach and esophagus of 121 patients...
  56. ncbi Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study
    J J Sung
    Endoscopy Center, Chinese University of Hong Kong, Hong Kong
    Gastroenterology 119:7-14. 2000
    Helicobacter pylori-infected gastric mucosa evolves through stages of chronic gastritis, intestinal metaplasia (IM), glandular atrophy (GA), and dysplasia before carcinoma develops. We studied if H...
  57. doi Definition of Barrett's esophagus: time for a rethink--is intestinal metaplasia dead?
    Robert H Riddell
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Gastroenterol 104:2588-94. 2009
    ..facts that goblet cells are uncommon in pediatric patients with BE, a small percentage of adults with columnar metaplasia of the esophagus do not contain goblet cells, the chances of detecting goblet cells are proportional to the ..
  58. ncbi Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
    Ben Z Stanger
    Howard Hughes Medical Institute and the Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cancer Cell 8:185-95. 2005
    ..Moreover, a fraction of these mice develop ductal malignancy. We provide evidence that ductal metaplasia results from the expansion of centroacinar cells rather than transdifferentiation of acinar cells...
  59. ncbi Metaplasia and transdifferentiation: from pure biology to the clinic
    Jonathan M W Slack
    Centre for Regenerative Medicine, University of Bath, Bath BA27AY, UK
    Nat Rev Mol Cell Biol 8:369-78. 2007
    ..This approach could generate new therapies for many human diseases...
  60. ncbi Divergent pathway of intestinal metaplasia and cystitis glandularis of the urinary bladder
    Ming Tse Sung
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 19:1395-401. 2006
    Intestinal metaplasia has been proposed to be a precursor lesion of adenocarcinoma in the urinary bladder...
  61. pmc TP53 and progression from Barrett's metaplasia to oesophageal adenocarcinoma in a UK population cohort
    L Murray
    Centre for Clinical and Population Sciences, The Queen s University of Belfast, Mulhouse Building, The Royal Group of Hospitals, Belfast, UK
    Gut 55:1390-7. 2006
    ..Oesophageal adenocarcinoma frequently develops on a background of metaplastic Barrett's epithelium. The development of malignancy is accompanied by genetic alterations, which may be promising biomarkers of disease progression...
  62. pmc Narrow band imaging for the detection of gastric intestinal metaplasia and dysplasia during surveillance endoscopy
    Lisette G Capelle
    Department of Gastroenterology and Hepatology, ErasmusUniversity Medical Center, Room L 462, 3015 CE Rotterdam, The Netherlands
    Dig Dis Sci 55:3442-8. 2010
    ..Narrow band imaging (NBI) may enhance the accuracy of endoscopic surveillance of intestinal metaplasia (IM) and dysplasia...
  63. pmc Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas
    Ilse Rooman
    Cell Differentiation Unit Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Am J Pathol 169:1206-14. 2006
    When pancreatic tissue is injured after duct obstruction, acinoductal metaplasia is observed. Similar metaplastic changes occur when exocrine pancreatic cells are isolated and cultured...
  64. ncbi Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis
    S Wang
    Division of Gastroenterology, Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Oncogene 25:3346-56. 2006
    ..These findings suggest that changes modulated at the molecular biologic level supervene earlier than histologic changes, and that BE is an early intermediate stage in the process of EAC...
  65. doi The use of dynamic positron emission tomography imaging for evaluating the carcinogenic progression of intestinal metaplasia to esophageal adenocarcinoma
    Yan Li
    Division of Surgical Oncology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Cancer Invest 26:278-85. 2008
    ....
  66. doi Smooth muscle metaplasia and innervation in interstitium of endometriotic lesions related to pain
    Kohei Odagiri
    Department of Obstetrics and Gynecology, Jichi Medical University Saitama Medical Center, Saitama, Japan
    Fertil Steril 92:1525-31. 2009
    ..To investigate the pathogenesis of endometriotic pain...
  67. pmc Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection
    Marrah E Lachowicz-Scroggins
    Department of Physiology and Membrane Biology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616 8643, USA
    Am J Respir Cell Mol Biol 43:652-61. 2010
    ..Even in mild asthma, airway epithelium exhibits mucous metaplasia, which increases with increasing severity of the disease...
  68. ncbi Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia
    Anna L Means
    Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Gastroenterology 124:1020-36. 2003
    ..This report examines the effects of HB-EGF overexpression in mouse pancreas...
  69. ncbi Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha
    S Y Song
    Department of Surgery, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center and Nashville VAMC, Nashville, TN 37232 2736, USA
    Gastroenterology 117:1416-26. 1999
    The progenitor cells responsible for transforming growth factor (TGF)-alpha-induced pancreatic ductal metaplasia and neoplasia remain uncharacterized...
  70. pmc SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia
    Thomas R Korfhagen
    Division of Neonatology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 109:16630-5. 2012
    ..Diverse toxic, inflammatory, and infectious insults induce airway mucus secretion and goblet cell metaplasia to preserve airway sterility and homeostasis...
  71. pmc Utility of subtyping intestinal metaplasia as marker of gastric cancer risk. A review of the evidence
    Carlos A Gonzalez
    Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology IDIBELL ICO, Barcelona, Spain
    Int J Cancer 133:1023-32. 2013
    ..The incomplete type of intestinal metaplasia (IM) could be considered as the best candidate for surveillance...
  72. ncbi Transdifferentiation and metaplasia--switching cell types
    J M Slack
    Developmental Biology Programme, Department of Biology and Biochemistry, University of Bath, Claverton Down, BA2 7AY, Bath, UK
    Curr Opin Genet Dev 11:581-6. 2001
    ..as combinations of transcription factors and changes in their expression can bring about transdifferentiation or metaplasia. For example, ectopic expressions of Vestigial can convert Drosophila leg to wing; of C/EBPbeta can convert ..
  73. pmc IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis
    Shui Ping Tu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
    Cancer Res 71:4247-59. 2011
    ....
  74. doi Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor
    Anna M Nicholson
    Department of Oncology, University of Oxford, Oxford, UK
    Gut 61:1380-9. 2012
    ..Using non-pathogenic mitochondrial DNA mutations as clonal markers, the authors reveal the stem cell organisation of the human squamous oesophagus and of Barrett's metaplasia and determine the mechanism of clonal expansion of mutations.
  75. ncbi Distribution and significance of epithelial types in columnar-lined esophagus
    P T Chandrasoma
    Departments of Surgical Pathology and Foregut Surgery, Keck School of Medicine at the University of Southern California, Los Angeles, USA
    Am J Surg Pathol 25:1188-93. 2001
    ..Recognition of these changes permits the development of morphologic definitions of reflux disease and the characterization of the sequence of epithelial changes that represent the reflux-adenocarcinoma sequence...
  76. doi SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans
    Miho Sashikawa Kimura
    Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Gastroenterol 46:1292-9. 2011
    ..However, the expression of SOX9 in normal stomach, precancerous intestinal metaplasia, and gastric carcinoma has not yet been clarified...
  77. pmc Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development
    Po Nien Tsao
    Department of Pediatrics, National Taiwan University Hospital, Taipei 100, Taiwan
    Development 138:3533-43. 2011
    Goblet cell metaplasia and mucus overproduction contribute to the pathogenesis of chronic lung diseases, including asthma and chronic obstructive pulmonary disease (COPD)...
  78. pmc Marginal turbid band and light blue crest, signs observed in magnifying narrow-band imaging endoscopy, are indicative of gastric intestinal metaplasia
    Jin Kwang An
    Department of Internal Medicine, Pusan National University School of Medicine, Ami dong, Seo Gu, Busan, Korea
    BMC Gastroenterol 12:169. 2012
    Gastric intestinal metaplasia (IM) usually appears in flat mucosa and shows few morphologic changes, making diagnosis using conventional endoscopy unreliable...
  79. pmc Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia
    Li Jyun Syu
    Department of Dermatology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Pathol 181:2114-25. 2012
    ..inflammation, expansion of myofibroblasts, loss of parietal and chief cells, spasmolytic polypeptide expressing metaplasia, and dysplasia...
  80. doi Gastric intestinal metaplasia revisited: function and regulation of CDX2
    Rita Barros
    IPATIMUP Institute of Molecular Pathology and Immunology, University of Porto, 4200 465 Porto, Portugal
    Trends Mol Med 18:555-63. 2012
    Intestinal metaplasia of the stomach is a preneoplastic lesion that appears following Helicobacter pylori infection and confers increased risk for gastric cancer development...
  81. pmc Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach
    Won Jae Huh
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 142:21-24.e7. 2012
    ..3 mg/20 g body weight dose of tamoxifen leads to apoptosis of >90% of all gastric parietal cells (PCs) and metaplasia of zymogenic chief cells within 3 days. Remarkably, gastric histology returns to nearly normal by 3 weeks...
  82. pmc The long term results of endoscopic surveillance of premalignant gastric lesions
    J L Whiting
    Department of Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Gut 50:378-81. 2002
    ..The proportion of these patients who go on to develop malignancies and the timescale over which this occurs are uncertain...
  83. pmc Narrow-band imaging with magnifying endoscopy is accurate for detecting gastric intestinal metaplasia
    Edoardo Savarino
    Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV, 16132 Genova, Italy
    World J Gastroenterol 19:2668-75. 2013
    To investigate the predictive value of narrow-band imaging with magnifying endoscopy (NBI-ME) for identifying gastric intestinal metaplasia (GIM) in unselected patients.
  84. ncbi A small proline-rich protein, SPRR1, is upregulated early during tobacco smoke-induced squamous metaplasia in rat nasal epithelia
    J Tesfaigzi
    Inhalation Toxicology Research Institute, Albuquerque, New Mexico 87185, USA
    Am J Respir Cell Mol Biol 14:478-86. 1996
    ..in the nasal transitional epithelium lining internal walls and maxilloturbinates that had undergone squamous metaplasia after cigarette smoke exposure...
  85. ncbi Review article: intestinal metaplasia and gastric carcinogenesis
    W K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, China
    Aliment Pharmacol Ther 16:1209-16. 2002
    Gastric intestinal metaplasia, an intermediate step in Correa's cascade of gastric carcinogenesis, is generally regarded as a pre-malignant lesion...
  86. ncbi Homeosis and intestinal tumours in Cdx2 mutant mice
    K Chawengsaksophak
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia
    Nature 386:84-7. 1997
    ..These polyps occasionally contain areas of true metaplasia. In contrast to the surrounding intestinal epithelium, the neoplastic cells do not express Cdx2 from the ..
  87. pmc Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets
    Mohamad El-Zaatari
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e58935. 2013
    Chronic inflammation in the stomach induces metaplasia, the pre-cancerous lesion that precedes inflammation-driven neoplastic transformation...
  88. pmc Vital-dye enhanced fluorescence imaging of GI mucosa: metaplasia, neoplasia, inflammation
    Nadhi Thekkek
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Gastrointest Endosc 75:877-87. 2012
    ..Multiscale endoscopy platforms that use widefield imaging are needed to better direct the placement of high-resolution probes...
  89. pmc Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance
    Adam Giangreco
    Centre for Respiratory Research, University College London, Rayne Institute, 5 University Street, London WC1E 6JF, UK
    J Pathol 224:190-202. 2011
    ..and determined that in vivo Myd88 deletion resulted in increased submucosal gland number, secretory cell metaplasia, and excess mucus cell abundance...
  90. pmc MicroRNAs up-regulated by CagA of Helicobacter pylori induce intestinal metaplasia of gastric epithelial cells
    Yongliang Zhu
    Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    PLoS ONE 7:e35147. 2012
    ..Overexpression of miRNA-584 and miRNA-1290 induced intestinal metaplasia of gastric epithelial cells in knock-in mice...
  91. doi Activation of the BMP4 pathway and early expression of CDX2 characterize non-specialized columnar metaplasia in a human model of Barrett's esophagus
    Daniel Castillo
    Section of Gastrointestinal Surgery, Parc de Salut Mar and Institut de Recerca Hospital del Mar IMIM Hospital del Mar, Universitat Autonoma de Barcelona, Passeig Maritim 25 29, 08003, Barcelona, Spain
    J Gastrointest Surg 16:227-37; discussion 237. 2012
    A human model of gastroesophageal reflux disease was used to examine the contribution of a non-specialized columnar type of metaplasia (NSCM) and key molecular events (BMP4 and CDX2) in the development of Barrett's esophagus.
  92. ncbi Feasibility and cost-effectiveness of using magnification chromoendoscopy and pepsinogen serum levels for the follow-up of patients with atrophic chronic gastritis and intestinal metaplasia
    Mario Dinis-Ribeiro
    Department of Gastroenterology, Portuguese Oncology Institute, Porto, Portugal
    J Gastroenterol Hepatol 22:1594-604. 2007
    The follow-up of patients with atrophic chronic gastritis or intestinal metaplasia may lead to early diagnosis of gastric cancer. However, to-date no cost-effective model has been proposed...
  93. pmc Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models
    Ming Chen
    Departments of Urology and Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Pathol 226:17-27. 2012
    Squamous metaplasia (SQM) is a specific phenotype in response to oestrogen in the prostate and oestrogen receptor (ER) α is required to mediate this response...
  94. pmc Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia
    G Shi
    Department of Biological Sciences and the Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907 2064, USA
    Oncogene 32:1950-8. 2013
    ..are induced to transdifferentiate, generating duct-like cells through a process known as acinar-ductal metaplasia (ADM)...
  95. ncbi Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated
    T Ohkusa
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Ann Intern Med 134:380-6. 2001
    Glandular atrophy and intestinal metaplasia are precancerous lesions; whether Helicobacter pylori eradication affects these lesions is controversial.
  96. pmc The metabolic marker tumour pyruvate kinase type M2 (tumour M2-PK) shows increased expression along the metaplasia-dysplasia-adenocarcinoma sequence in Barrett's oesophagus
    K Koss
    Department of Gastroenterology, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
    J Clin Pathol 57:1156-9. 2004
    ..In tumours cells, M2-PK usually exists in dimeric form (tumour M2-PK), causing the accumulation of glycolytic phosphometabolites, which allows cells to invade areas with low oxygen and glucose concentrations...
  97. pmc Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement
    Feng Xia Liang
    Epithelial Biology Unit, The Ronald O Perelman Department of Dermatology
    J Cell Biol 171:835-44. 2005
    ..lineages, that trigone urothelium is closely related to the urothelium covering the rest of the bladder, and that lineage heterogeneity coupled with cell migration/replacement form the cellular basis for urothelial squamous metaplasia.
  98. pmc Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils
    Masahiro Kusunoki
    Department of Matrix Medicine, Faculty of Medicine, Oita University, Idaigaoka 1 1, Hasama machi, Yufu, Oita, 879 5593, Japan
    Environ Health Prev Med 16:224-31. 2011
    ..The causal agents of gastric cancer could include fungus toxins. Sterigmatocystin (ST), a fungus toxin, is a risk factor of gastric cancer. We investigated the effects of ST on the stomach tissues of Mongolian gerbils...
  99. pmc Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia
    David H Wang
    Graduate Training Program in Cellular and Molecular Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Gastroenterology 138:1810-22. 2010
    The molecular mechanism underlying epithelial metaplasia in Barrett's esophagus remains unknown...
  100. doi Impact of inflammation-metaplasia-adenocarcinoma sequence and prevention in surgical rat models
    Tomoharu Miyashita
    Department of Gastroenterologic Surgery, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Digestion 87:6-11. 2013
    ..reflux from gastroesophageal reflux disease induces the inflammation-mediated progression from hyperplasia to metaplasia, and to adenocarcinoma...
  101. pmc Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study
    Feng Zhu
    Department of Medicine, National University of Singapore, Singapore, Singapore
    BMC Gastroenterol 9:76. 2009
    Intestinal metaplasia (IM) is an important precursor lesion in the development of gastric cancer (GC). The aim of this study was to investigate genetic factors previously linked to GC risk for their possible association with IM...

Research Grants78

  1. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..will be sacrificed and the gastrointestinal and native bladder tissues will be examined histologically for metaplasia and dysplasia...
  2. Epithelial differentiation in cornea
    Bogi Andersen; Fiscal Year: 2012
    ..Squamous metaplasia and altered differentiation are also a hallmark of several corneal diseases that cause blindness;understanding ..
  3. Mouse models for esophageal Cox-2 oxidative stress and DNA damage
    John P Lynch; Fiscal Year: 2013
    ..esophagitis that models GERD esophagitis by provoking oxidative stress, DNA damage, and the development of metaplasia and dysplasia...
  4. Mechanisms of oxidant-induced chronic bronchitis
    ROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012
    ..RON signaling, thereby allowing EGF receptor-ligand interaction, which ultimately results in airway mucous cell metaplasia and hypersecretion...
  5. Modeling oxidative stress and DNA damage using GI organotypic culture systems
    John P Lynch; Fiscal Year: 2013
    ..DNA damage and mutations, and alter DNA methylation patterns, which together contributes to the development of metaplasia and cancer. We have begun to explore this using organotypic culture systems to model Cox-2 in BE pathogenesis...
  6. The Unfolded Protein Response in Human Airway and Alveolar Epithelial Cells
    Salim Merali; Fiscal Year: 2010
    ..chronic obstructive pulmonary disease (COPD) is characterized by alveolar epithelial cell death and airway metaplasia and fibrosis...
  7. Transcriptional Control of Submucosal Gland Formation and Function
    Jeffrey A Whitsett; Fiscal Year: 2013
    ..These disorders are complicated by mucus metaplasia, mucus hyperproduction or inspissation, inflammation, and susceptibility to pulmonary infection...
  8. Mining open chromatin to define molecular mechanisms of CF modifier genes
    WANDA K O'NEAL; Fiscal Year: 2013
    ..reduced mucociliary clearance, chronic bacterial infection, inflammatory airway disease with mucus hyper/metaplasia, respiratory failure, and early death...
  9. Oxyntic Atrophy and Novel Gastric Lineages
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
    ..is well established, the cellular basis of lineage changes that lead to development of preneoplastic metaplasia and progression to cancer remain unclear...
  10. Role of Calcium-Activated Chloride Channels in Airway Disease Phenotypes
    ANAND CHAMPAK PATEL; Fiscal Year: 2011
    Airway hyperresponsiveness and mucous cell metaplasia are essential features of inflammatory airway diseases (including asthma and COPD), but the cellular and molecular pathways leading to these disease traits still need to be better ..
  11. Airway epithelial repair in chronic bronchitis: novel signaling mechanisms
    Andreas Schmid; Fiscal Year: 2013
    ..effects on Wnt signaling and evaluate possible therapeutic options to improve ciliogenesis and prevent squamous metaplasia. These pathways are poorly studied in the airway, despite their importance for proper epithelial cell repair...
  12. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
    ..causes a cascade of molecular and morphologic changes in the inflamed epithelium leading to mucosal atrophy, metaplasia, dysplasia and eventually gastric cancer...
  13. Identification and Characterization of the Mouse PPCD1 Gene
    Christopher A Bradfield; Fiscal Year: 2013
    ..arose from a spontaneous mutation in our mouse colony and exhibits an enlarged anterior chamber secondary to metaplasia of the corneal endothelium and blockage of the iridocorneal angle by the epithelialized corneal endothelial ..
  14. Airway epithelial repair in chronic bronchitis: novel signaling mechanisms
    Andreas Schmid; Fiscal Year: 2011
    ..effects on Wnt signaling and evaluate possible therapeutic options to improve ciliogenesis and prevent squamous metaplasia. These pathways are poorly studied in the airway, despite their importance for proper epithelial cell repair...
  15. Airway Goblet Cells: Friend or Foe?
    David A Stoltz; Fiscal Year: 2012
    ..lungs? Second, are goblet cells and mucus important for responding to airway insults? Third, are goblet cell metaplasia/hyperplasia and mucus hypersecretion beneficial in diseased lungs? Most airway studies, to date, have been ..
  16. Airway Epithelial Responses to Allergic Inflammation
    David J Erle; Fiscal Year: 2010
    ..interleukin-13 (IL-13) is directly responsible for the development of mucus-producing goblet cells (mucus metaplasia) in allergic models...
  17. Molecular Pathobiology of Barrett's Tumorigenesis
    Wael El-Rifai; Fiscal Year: 2013
    ..cells to stress and generation of reactive oxygen species (ROS) which leads to the development of esophageal metaplasia, known as Barrett's esophagus (BE)...
  18. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2013
    ..by applicant): Epithelial cell hyperplasia in response to an inflammatory response is accompanied by mucous cell metaplasia (MCM), the appearance of mucous cells in airways that are normally devoid of these cells...
  19. Pancreas Transcription Factors and Disease Model Systems
    Stephen F Konieczny; Fiscal Year: 2013
    ..of the Mist1KO pancreas defects, identify key Mist1 target genes, establish how Mist1 prevents acinar-ductal metaplasia, and assess the role of Mist1 within the UPR...
  20. Mechanisms of CDX2 regulation of the IGF axis
    Duyen Dang; Fiscal Year: 2013
    ..Aberrant CDX2 expression has been linked to gastric intestinal metaplasia, leukemia, and various solid tumors, including up to 90% of colonic adenomas and adenocarcinomas...
  21. Great Lakes/New England Clinical Validation Center
    Dean E Brenner; Fiscal Year: 2013
    ..detection of colorectal adenocarcinoma and 3 biomarkers for the detection of progression of lower esophageal metaplasia to dysplasia and carcinoma...
  22. Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelia
    Jeffrey A Whitsett; Fiscal Year: 2013
    ..application seeks funding to define a transcriptional network that determines AEC differentiation, goblet cell metaplasia/hyperplasia, and inflammation related to the pathogenesis of asthma, other chronic pulmonary disorders, and ..
  23. The Role of microRNA Alterations in Barrett's Carcinogenesis
    Stephen J Meltzer; Fiscal Year: 2012
    ..To prove this hypothesis, we will compare miR expression levels at all stages of BE-associated metaplasia, dysplasia, and adenocarcinoma as well as in normal squamous esophagus...
  24. Dual Oxidase in Airway Epithelial Injury and Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ..increased DUOX1 expression in models of allergic asthma in association with increased EGFR activation and mucus metaplasia. The respiratory epithelium is critical in coordinating innate and adaptive immune responses to airborne ..
  25. Engineering of Human Corneal Endothelial Grafts
    Ying Ting Zhu; Fiscal Year: 2012
    ..activates [unreadable]-catenin/Wnt signaling and runs the risk of losing the normal phenotype to fibrous metaplasia because of endothelial-mesenchymal transition (EMT)...
  26. Serum biomarkers for early detection of H. pylori-associated gastric cancer
    Jay V Solnick; Fiscal Year: 2013
    ..sequence of pathologic changes that leads from chronic non-atrophic gastritis, to atrophic gastritis, intestinal metaplasia, dysplasia, and finally gastric adenocarcinoma...
  27. Targeting CaM Kinase II and Oxidative Damage in Allergic Asthma
    Howard Schulman; Fiscal Year: 2011
    ..tested for efficacy in the ovalbumin mouse model of allergic asthma, monitoring its efficacy in AHR, goblet cell metaplasia, and mucous secretion...
  28. Neutrophil Subsets in Post-Viral Asthma
    Dorothy S Cheung; Fiscal Year: 2013
    ..to the later development of post-viral atopic airways disease (persistent airway hyperreactivity and mucus cell metaplasia)...
  29. Generation of lung progenitors from Cystic Fibrosis iPS cells
    Jayaraj Rajagopal; Fiscal Year: 2013
    ..They are often characterized by abnormalities of the lung epithelium including epithelial hyperplasia, mucous metaplasia, epithelial dysplasia and the failure of epithelial regeneration after injury...
  30. Regulation of mucous cell metaplasia in asthma
    Yohannes Tesfaigzi; Fiscal Year: 2012
    ..This phenotype is called mucous cell metaplasia (MCM)...
  31. IL-13 and IL-17 dynamics in the asthmatic airway
    Dean Sheppard; Fiscal Year: 2013
    ..contributions to the most critical functional endpoints in asthma (airway hyperresponsiveness and mucus metaplasia) through spatially and temporally restricted effects on airway epithelial cells and airway smooth muscle...
  32. ADAM17 in pancreatic cancer and pancreatitis
    Howard C Crawford; Fiscal Year: 2013
    ..Besides inflammation, the two diseases have many common features, including ductal metaplasia and fibrosis, both of which may significantly enhance PDA formation...
  33. Clinical Studies on Bile Acids in Barrett's Esophagus
    Stuart Jon Spechler; Fiscal Year: 2012
    ..Such apoptotic resistance might underlie the pathogenesis and persistence of Barrett's metaplasia, as esophageal squamous cells that succumb to bile acid-induced apoptosis are replaced by apoptosis-resistant ..
  34. Defining the molecular mechanisms underlying human RPE plasticity
    Sally Temple; Fiscal Year: 2013
    ..RPE metaplasia into mesenchymal-related cells has been long -associated with retinal disease, yet the mechanism underlying ..
  35. CELLULAR AND MOLECULAR MECHANISMS OF GASTROINTESTINAL CANCERS
    Lopa Mishra; Fiscal Year: 2013
    ..few viable targeted therapeutics and unclear molecular profiling of each stage of tumon development, from metaplasia to dysplasia to carcinoma...
  36. MOLECULAR REGULATION OF GASTRIC CHIEF (ZYMOGENIC) CELL DIFFERENTIATION
    Jason C Mills; Fiscal Year: 2012
    ..injured gastric epithelium is characterized by cell lineage drop-out (atrophy) and aberrant differentiation (metaplasia)...
  37. Mechanisms of Gastric Mucous Cell Metaplasia
    JAMES RICHARD GOLDENRING; Fiscal Year: 2012
    ..The loss of parietal cells in humans leads to the development of two identifiable metaplasias: intestinal metaplasia (the presence of intestinal goblet cells in the gastric mucosa) and spasmolytic polypeptide expressing ..
  38. Modulation of conjunctival goblet cell differentiation by immunoregulatory cells
    Cintia Sade de Paiva; Fiscal Year: 2010
    ..be confirmed by evaluating goblet cell and CD4+ cell density and expression of the goblet cell mucin MUC5AC and metaplasia marker small proline rich residue 2 protein (SPRR-2) in conjunctival sections from normal and dry eye mice...
  39. Basic and Clinical Studies on the Role of Bile Acids in Barrett's Esophagus
    Stuart Jon Spechler; Fiscal Year: 2013
    ..Such apoptotic resistance might underlie the pathogenesis and persistence of Barrett's metaplasia, as esophageal squamous cells that succumb to bile acid-induced apoptosis are replaced by apoptosis-resistant ..
  40. Role of Squamous Metaplasia in Small Airways Disease in COPD
    Stephen L Nishimura; Fiscal Year: 2010
    ..activation leads to replacement of the ciliated airway lining cells with squamous epithelium (called squamous metaplasia), which resemble epidermal cells...
  41. Molecular mechanisms of squamous metaplasia in dry eye
    Nancy A McNamara; Fiscal Year: 2013
    ..This process, known as squamous metaplasia (SQM), is a devastating, end-stage consequence of dry eye disease that can cause considerable morbidity as ..
  42. Molecular Pathobiology of Gastric Carcinogenesis
    Wael El-Rifai; Fiscal Year: 2013
    ..the loss of TFF1 in human gastric cancer coincides with early stages of gastric cancer development;intestinal metaplasia and dysplasia, 4) TFF1 knockout (KO) mice develop a cascade of: spontaneous chronic inflammation in gastric ..
  43. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2012
    ..COX-2 pancreata. Aim 3 will determine whether prostaglandins are driving acinar metaplasia by elevating cytokines that then recruit leukocytes...
  44. Severe Asthma Research Program (SARP)-Washington University
    Mario Castro; Fiscal Year: 2013
    ..We have demonstrated that epithelial hyperplasia, goblet cell metaplasia and mucin production are features of airway remodeling in subjects with severe asthma, and that epithelial ..
  45. microRNAs in the airway epithelium
    Edwin J Ostrin; Fiscal Year: 2013
    ..interleukin-13 (IL-13) drives characteristic alterations in epithelial gene expression leading to mucous metaplasia in mouse models and in a large subset of human subjects with asthma...
  46. DNA Damage Response Markers in Barrett's Esophagus
    Gregory H Enders; Fiscal Year: 2010
    ..Intestinal metaplasia, a condition commonly referred to as Barrett's esophagus, is associated with increased risk of EAC...
  47. Biomarkers of Progression to Esophageal Adenocarcinoma
    GIULIANA JULIE IZZO; Fiscal Year: 2010
    ..D1 (CD1) G/A870 polymorphism results in a higher risk of progression from Barrett's esophagus (BE) with metaplasia to high-grade dysplasia (HGD) but also to [1] establish that this polymorphism results in functional ..
  48. Role of IL-6/STAT3 Signaling in the Neoplastic Progression of Barrett's Esophagus
    Rhonda F Souza; Fiscal Year: 2013
    ..by limited understanding of the molecular events underlying the neoplastic progression of Barrett's metaplasia. During carcinogenesis in Barrett's esophagus, genetic alterations accumulate that enable the cells to ..
  49. The Intestinal Stem Cell Niche
    Anil K Rustgi; Fiscal Year: 2013
    ..Errors in stem cell identity are encountered in intestinal metaplasia of the esophagus and stomach, as well as many gastrointestinal cancers...
  50. Molecular genetic analysis of tyrosine kinases in myeloproliferative disorders
    Ross L Levine; Fiscal Year: 2010
    ..to identify the genetic basis for polycythemia vera (PV), essential thrombocythemia (ET) and agnogenic myeloid metaplasia (AMM), and to develop more effective treatments or these disorders based on genetic insights into disease ..
  51. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..CF starts as acinar plugs in utero and progresses over time to acinar cell atrophy, duct dilatation, mucous cell metaplasia and fibrosis...
  52. Diagnosis of Cervical Precancers Using Raman Spectroscopy
    Anita Mahadevan-Jansen; Fiscal Year: 2012
    ..can provide differential diagnosis of cervical precancers, both high and low grade from inflammation, squamous metaplasia and normal areas of the cervix...
  53. IL-13 Associated Eosinophil Lung Responses
    Marc E Rothenberg; Fiscal Year: 2013
    ..g. goblet cell metaplasia)...
  54. Cellular Decisions of Differentiation in the GI Tract
    Juanita L Merchant; Fiscal Year: 2013
    ..Subproject #2 entitled "Role of Hedgehog signaling in chronic gastritis and metaplasia" will examine the role of chronic inflammation, specifically proinflammatory cytokines in mediating changes in ..
  55. Naturally occurring T regulatory cells control airway hyperresponsiveness
    ERWIN WILLIAM GELFAND; Fiscal Year: 2013
    ..including airway hyperresponsiveness (AHR), airway eosinophilia, Th2 cytokine production, and goblet cell metaplasia. Conversely, depletion of these cells with anti-CD25 enhanced all of these responses...
  56. Inducible epithelial antiviral resistance to prevent asthma
    Scott E Evans; Fiscal Year: 2013
    ..allergic inflammation and to protect against viruses without exacerbating airways hyperreactivity or mucous metaplasia. However, the deeply entrenched position that all inflammation is harmful to asthma patients demands that the ..
  57. Th17 inflammation is responsible for mucous metaplasia in COPD
    Victor Kim; Fiscal Year: 2013
    ..This is characterized pathologically by mucous metaplasia of the airway epithelial layer...
  58. ERalpha in prostate homeostasis and cancer
    Shuyuan Yeh; Fiscal Year: 2013
    ..the kidney capsule, concluded that both epithelial and stromal ERa are required for estrogen-mediated squamous metaplasia;yet, the field debated that the stromal or epithelial cells isolated from the anterior prostate, which has a ..
  59. Role of PKC iota in metaplasia and initiation of pancreatic cancer
    Nicole R Murray; Fiscal Year: 2013
    ..Expression of oncogenic K-ras in mouse pancreatic epithelium induces ductal metaplasia, followed by formation of preneoplastic lesions, mouse pancreatic intraepithelial neoplasias (mPanINs) with the ..
  60. CysLT and P2Y Receptors in Lung Inflammation
    Joshua A Boyce; Fiscal Year: 2013
    ..from the HDM to C57BL/6 or BALB/c mice causes robust peribronchial and perivascular eosinophilia, goblet cell metaplasia, and a mixed T helper (Th)2, Th1, and Th17-type immune response in the lungs...
  61. MECHANISMS IN THE REMODELING OF LUNG STRUCTURE
    Michael J Holtzman; Fiscal Year: 2012
    ..pathway for matrilysin activation;and (4) a distinct NBNT lymphoid cell population is involved in mucous cell metaplasia following respiratory viral infections...
  62. IL-13 Atopic Dermatitis and Its Relationship with the Development of Asthma
    Tao Zheng; Fiscal Year: 2012
    ..Moreover, IL-13-induced dermatitis is associated with increased pulmonary inflammation, mucus metaplasia and airway hyperresponsiveness to allergen challenges, suggesting that IL-13 induced AD predisposes to an asthma ..
  63. The role of Hedgehog Signaling in gastric tissue homeostasis and disease
    Yana Zavros; Fiscal Year: 2013
    ..proposed is that, identified Hedgehog signaling tar- gets that are crucial for the development of gastritis and metaplasia may be applied as biomarkers for cancer diagnostics, prognostics and targeted therapeutics...
  64. H PYLORI AND GASTRIC PRENEOPLASTIC LESIONS
    Julie Parsonnet; Fiscal Year: 1999
    ..is preceded by a sequence of histologic changes including chronic atrophic gastritis (CAG), intestinal metaplasia (IM), and dysplasia. Each step in the preneoplastic sequence increases risk for later development of malignancy...
  65. Apoptosis in myelofibrosis with myeloid metaplasia
    Ruben Mesa; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Myelofibrosis with myeloid metaplasia is a clonal hematopoietic stem cell disorder that results in progressive cytopenias, splenomegaly, blastic transformation, and death...
  66. LOCALIZED VITAMIN DEFICIENCIES AND RISK FOR LUNG CANCER
    Chandrika Piyathilake; Fiscal Year: 2001
    ..by the reports of lower circulating and buccal mucosal folate levels in smokers, and a response of bronchial metaplasia to folate/B-12 supplementation...
  67. The Role of RAGE in Asbestosis
    Tim Oury; Fiscal Year: 2007
    ..However, in renal fibrosis RAGE signaling has been found to be a central mechanism in stimulating myofibroblast metaplasia. Importantly, myofibroblastic foci are believed to be key mediators of disease progression in fibrotic lung ..
  68. TISSUE SPECIFIC EXPRESSION AND FUNCTION OF ME-RABP
    Marie Claire Orgebin Crist; Fiscal Year: 2002
    ..Targeted mutation of the retinoic acid receptor alpha (RARalpha) results in squamous metaplasia of the epididymal epithelium with resulting infertility (1)...
  69. Risk factors for gastric disease in pediatric H. pylori
    Benjamin Gold; Fiscal Year: 2006
    ..a histopathologic spectrum in children, which included novel observations of atrophic gastritis with intestinal metaplasia. Overall hypothesis for competitive renewal: disease manifestations in Hp-infected children are influenced by ..
  70. P53 AND DNA PLOIDY IN BARRETT'S METAPLASIA
    Mamoun Younes; Fiscal Year: 2005
    ..endoscopic surveillance protocols aimed at detecting early malignant transformation in patients with Barrett's metaplasia (BM) can be improved by: 1) testing the hypothesis that p53 protein accumulation, DNA aneuploidy, and increased ..
  71. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..Clinical and epidemiologic studies suggest that the development of atrophic gastritis intestinal metaplasia and dysplasia represent essential steps in the cascade of events leading to gastric cancer...
  72. EPIDEMIOLOGY OF BARRETTS ESOPHAGUS
    Thomas Vaughan; Fiscal Year: 2000
    ..N=335) to test the hypothesis that specific environmental exposures and host factors increase risk of Barrett's metaplasia, and to estimate the fraction of cases attributable to them...
  73. GASTRIC CANCER INDUCED BY H PYLORI IN P27 DEFICIENT MICE
    Steven Moss; Fiscal Year: 2009
    ..These changes were preceded by marked gastric inflammation and the early development of intestinal metaplasia. We propose to test the following hypotheses: 1...
  74. CHEMOPREVENTION IN HUMAN BRONCHIAL METAPLASIA/DYSPLASIA
    WAUN HONG; Fiscal Year: 1991
    ..Squamous metaplasia that develops during vitamin A deficiency resembles the premalignancy caused by chemical carcinogens...
  75. The Prevalence of Barrett's Esophagus in Patients with *
    Blair Jobe; Fiscal Year: 2004
    The incidence of esophageal adenocarcinoma arising from Barrett's metaplasia has increased by 350% since 1970 and at the time of presentation, 50% of patients will have advanced disease with virtually no chance for cure...
  76. NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2007
    ..The specialized intestinal metaplasia of BE is associated with nearly a 30-125-fold increased risk for the development of esophageal adenocarcinoma...
  77. Mouse Model of Pancreatic Tumorigenesis with Dysregulation of mTOR
    Chongjuan Wei; Fiscal Year: 2009
    ..the LKB1 conditional knockout, the PDXCre transgene, and wild type p53 indicate that pancreatic acinar-to-ductal metaplasia develops at 2-3 months of age. Metaplasia is a harbinger of cancer in many tissues...
  78. EVALUATION OF RISK FACTORS FOR BARRETT'S ESOPHAGUS
    Douglas Corley; Fiscal Year: 2001
    ..rationale for characterizing the environmental, behavioral, or genetic factors associated with Barrett's metaplasia development, and describing the risk factors for its progression to neoplasia. Hypotheses: A...